[ { "uniprot_canonical_ac": "P09055-1", "uniprot_id": [ { "id": "ITB1_MOUSE", "url": "https://www.uniprot.org/uniprot/P09055", "type": "external" } ], "mass": 88231.0, "length": 798, "protein_name": "Integrin beta-1", "gene_name": "Itgb1", "organism": "Mouse", "refseq_name": "integrin beta-1 precursor", "refseq_ac": [ { "id": "NP_034708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034708", "type": "external" } ], "gene_names_uniprotkb": "Itgb1", "gene_names_refseq": "4633401G24Rik; CD29; Fnrb; Gm9863; Itgb1; gpIIa", "protein_names_uniprotkb": "Integrin beta-1; Fibronectin receptor subunit beta; VLA-4 subunit beta", "protein_names_refseq": "VLA-4 subunit beta; fibronectin receptor subunit beta; integrin beta-1 precursor; integrin beta-1", "tax_id": 10090, "disease": "Hirschsprung's disease (Disease Ontology:DOID:10487); hydrocephalus (Disease Ontology:DOID:10908); cancer (Disease Ontology:DOID:162); glomerulonephritis (Disease Ontology:DOID:2921); IgA glomerulonephritis (Disease Ontology:DOID:2986); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung small cell carcinoma (Disease Ontology:DOID:5409); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:16412); (R-MMU-1566948); (R-MMU-1566977); (R-MMU-198933); (R-MMU-202733); (R-MMU-210991); (R-MMU-2129379); (R-MMU-216083); (R-MMU-2173789); (R-MMU-3000157); (R-MMU-3000170); (R-MMU-3000178); (R-MMU-445144); (R-MMU-446343); (R-MMU-8874081); (R-MMU-8875513); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013408); (R-MMU-9013423); (R-MMU-9634597); (R-MMU-9860927)", "pathway_count": 22, "publication_count": 51, "publication_id_list": "10.1101/2023.09.13.557529;10634791;11465105;11805835;12189152;12941630;15181153;15466886;15734730;16075062;16405888;17947660;18483218;18804435;19144319;19656770;19903482;21750661;21768292;22654117;2521606;2523953;25428506;26495903;26740625;28011936;28179430;28528544;29187734;30084848;30250269;30899004;31219806;32152506;3262537;33300544;34427057;34428180;34678516;35802072;36288343;36812915;37828378;38061240;39627609;39927985;40885482;40997131;8567725;8870969;9553049", "class_list": "", "function": "Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (PubMed:10634791, PubMed:36812915). Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition (PubMed:12941630). Involved in promoting endothelial cell motility and angiogenesis (PubMed:15181153). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules (PubMed:21768292). May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis (PubMed:18804435). ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (By similarity). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (By similarity). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). ITGA5:ITGB1 acts as a receptor for fibronectin FN1 and mediates R-G-D-dependent cell adhesion to FN1 (By similarity). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (By similarity). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (By similarity). Plays an important role in myoblast differentiation and fusion during skeletal myogenesis (By similarity). ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion (PubMed:22654117). Integrins ITGA9:ITGB1 and ITGA4:ITGB1 repress PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via their interaction with SVEP1, thereby inhibit vasocontraction (PubMed:35802072)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Isoform 2 displaces isoform 1 in striated muscles., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 10, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 9, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 10, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 10, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 35, "disease_count": 8, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "F6R105;Q3TIW5;Q3TWH6;Q60993;Q61126;Q8BTU0;Q8BVU1", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0002020 protease binding;GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0005178 integrin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0035748 myelin sheath abaxonal region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0001708 cell fate specification;GO:0007161 calcium-independent cell-matrix adhesion;GO:0023035 CD40 signaling pathway;GO:0001525 angiogenesis;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 10.0, "record_id": "P09055-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61249-1", "uniprot_id": [ { "id": "IGBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61249", "type": "external" } ], "mass": 38971.0, "length": 340, "protein_name": "Immunoglobulin-binding protein 1", "gene_name": "Igbp1", "organism": "Mouse", "refseq_name": "immunoglobulin-binding protein 1", "refseq_ac": [ { "id": "NP_032810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032810", "type": "external" } ], "gene_names_uniprotkb": "Igbp1; Pc52", "gene_names_refseq": "Igbp1; Pc52; Tap42; p52", "protein_names_uniprotkb": "Immunoglobulin-binding protein 1; Alpha4 phosphoprotein; CD79a-binding protein 1; Lymphocyte signal transduction molecule alpha 4; Protein phosphatase 2/4/6 regulatory subunit; p52", "protein_names_refseq": "CD79a-binding protein 1; alpha4 phosphoprotein; immunoglobulin-binding protein 1; lymphocyte signal transduction molecule alpha 4; phosphoprotein, component, 52 kDa; protein phosphatase 2/4/6 regulatory subunit", "tax_id": 10090, "disease": "corpus callosum agenesis-intellectual disability-coloboma-micrognathia syndrome (Disease Ontology:DOID:0060816)", "pathway": " (mmu:18518)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21454489;25428506;28135057;28526910;30084848;34428180;35820727;7876543;9573385", "class_list": "", "function": "Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits., [UniProtKB]; Both the C-terminal Mid1-binding domain and the PP2Ac-binding determinants are required for Alpha4-mediated protection of PP2Ac from polyubiquitination and degradation., [RefSeq, PubMed]; Report the significance and altered activity of the type 2A protein phosphatase-alpha4 complex in healthy and hypertrophied myocardium., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0031434 mitogen-activated protein kinase kinase binding;GO:0019888 protein phosphatase regulator activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0035303 regulation of dephosphorylation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0042113 B cell activation;GO:2001234 negative regulation of apoptotic signaling pathway;GO:0035306 positive regulation of dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q61249-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61739-1", "uniprot_id": [ { "id": "ITA6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61739", "type": "external" } ], "mass": 122159.0, "length": 1091, "protein_name": "Integrin alpha-6", "gene_name": "Itga6", "organism": "Mouse", "refseq_name": "integrin alpha-6 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001264899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264899", "type": "external" } ], "gene_names_uniprotkb": "Itga6", "gene_names_refseq": "5033401O05Rik; Cd49f; Itga6; VLA-6", "protein_names_uniprotkb": "Integrin alpha-6; CD49 antigen-like family member F; VLA-6", "protein_names_refseq": "CD49 antigen-like family member F; integrin alpha-6 isoform 2 precursor", "tax_id": 10090, "disease": "junctional epidermolysis bullosa with pyloric atresia (Disease Ontology:DOID:0060733); junctional epidermolysis bullosa Herlitz type (Disease Ontology:DOID:0060737); cancer (Disease Ontology:DOID:162); epilepsy (Disease Ontology:DOID:1826); junctional epidermolysis bullosa (Disease Ontology:DOID:3209)", "pathway": " (mmu:16403); (R-MMU-210991); (R-MMU-216083); (R-MMU-3000157); (R-MMU-3000170); (R-MMU-446107)", "pathway_count": 6, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;10634791;10825303;11359780;19349973;20664806;21750661;26740625;30899004;31219806;32152506;34428180;37828378;38835038;39627609;8081870;8673141", "class_list": "", "function": "Alpha-6 integrin deletion delays the formation of Brca1/p53-deficient basal-like breast tumors by restricting luminal progenitor cell expansion. Publication Status: Online-Only, [RefSeq, PubMed]; Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (PubMed:8081870). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (PubMed:10634791). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (PubMed:8673141). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (By similarity). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (By similarity). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling., [UniProtKB, UniProtKB]; This gene encodes a protein that is a member of the integrin superfamily. Integrins are transmembrane receptors involved cell adhesion and signaling, and they are subdivided based on the heterodimer formation of alpha and beta chains. This protein has been shown to heterodimerize with beta 4 to bind laminin and to form the main component of hemidesmosomes, which mediate attachment of epithelia to basement membranes. In mouse, deficiency of this gene is associated with absence of hemidesmosomes, severe skin blistering, and early post-natal death. In humans mutations of this gene are associated with epidermolysis bullosa. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, May 2013]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 5, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A2AU04", "ec_number_list": [], "go_molecular_function": "GO:0038132 neuregulin binding;GO:0005178 integrin binding;GO:0046872 metal ion binding;GO:0043236 laminin binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0045178 basal part of cell", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0010976 positive regulation of neuron projection development;GO:0030335 positive regulation of cell migration;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q61739-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R5F7-1", "uniprot_id": [ { "id": "IFIH1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R5F7", "type": "external" } ], "mass": 115971.0, "length": 1025, "protein_name": "Interferon-induced helicase C domain-containing protein 1", "gene_name": "Ifih1", "organism": "Mouse", "refseq_name": "interferon-induced helicase C domain-containing protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001157949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157949", "type": "external" } ], "gene_names_uniprotkb": "Ifih1", "gene_names_refseq": "9130009C22Rik; Helicard; Hlcd; Ifih1; MDA5; RLR-2", "protein_names_uniprotkb": "Interferon-induced helicase C domain-containing protein 1; 3.6.4.13; Helicard; Helicase with 2 CARD domains; Interferon induced with helicase C domain protein 1; MDA-5; Melanoma differentiation-associated protein 5; RIG-I-like receptor 2; RLR-2", "protein_names_refseq": "RIG-I-like receptor 2; helicase with 2 CARD domains; interferon induced with helicase C domain protein 1; interferon-induced helicase C domain-containing protein 1 isoform 2; interferon-induced helicase C domain-containing protein 1; melanoma differentiation-associated protein 5", "tax_id": 10090, "disease": "Aicardi-Goutieres syndrome (Disease Ontology:DOID:0050629); immunodeficiency 95 (Disease Ontology:DOID:0061065); Fanconi anemia (Disease Ontology:DOID:13636); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:71586); (R-MMU-5689880)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "11805321;12015121;16116171;16625202;17242355;17942531;19144319;19656871;20950133;21183079;21217758;21245900;21616437;21884169;22314235;34428180", "class_list": "", "function": "Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and pro-inflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV), mengo encephalomyocarditis virus (ENMG), and theiler's murine encephalomyelitis virus (TMEV). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AUY7;Q3U6S2;Q68EM4;Q8BYC9;Q8BZ01;Q8K5C7;Q8R144;Q8VE79;Q99KS4;Q9D2Z5", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.26.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.26.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0032727 positive regulation of interferon-alpha production;GO:0060760 positive regulation of response to cytokine stimulus;GO:0016925 protein sumoylation;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8R5F7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DA69-1", "uniprot_id": [ { "id": "IFT43_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DA69", "type": "external" } ], "mass": 23501.0, "length": 206, "protein_name": "Intraflagellar transport protein 43 homolog", "gene_name": "Ift43", "organism": "Mouse", "refseq_name": "intraflagellar transport protein 43 homolog isoform 1", "refseq_ac": [ { "id": "NP_001186772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186772", "type": "external" } ], "gene_names_uniprotkb": "Ift43", "gene_names_refseq": "1700019E19Rik; Ift43", "protein_names_uniprotkb": "Intraflagellar transport protein 43 homolog", "protein_names_refseq": "intraflagellar transport 43 homolog; intraflagellar transport protein 43 homolog isoform 1; intraflagellar transport protein 43 homolog", "tax_id": 10090, "disease": "retinitis pigmentosa 81 (Disease Ontology:DOID:0080292); short-rib thoracic dysplasia 18 with polydactyly (Disease Ontology:DOID:0080293); cranioectodermal dysplasia 3 (Disease Ontology:DOID:0080805)", "pathway": " (mmu:76411); (R-MMU-5620924)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;25243405;28973684", "class_list": "", "function": "As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis. Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFI3;Q8K213", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005929 cilium;GO:0015630 microtubule cytoskeleton;GO:0045171 intercellular bridge;GO:0005814 centriole", "go_biological_process": "GO:0060271 cilium assembly;GO:0035721 intraciliary retrograde transport;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DA69-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97794-1", "uniprot_id": [ { "id": "KCNJ8_MOUSE", "url": "https://www.uniprot.org/uniprot/P97794", "type": "external" } ], "mass": 47980.0, "length": 424, "protein_name": "ATP-sensitive inward rectifier potassium channel 8", "gene_name": "Kcnj8", "organism": "Mouse", "refseq_name": "ATP-sensitive inward rectifier potassium channel 8 isoform 1", "refseq_ac": [ { "id": "NP_001317292", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317292", "type": "external" } ], "gene_names_uniprotkb": "Kcnj8", "gene_names_refseq": "Kcnj8; Kir6.1; gnite; slmbr; sltr; uKATP-1", "protein_names_uniprotkb": "ATP-sensitive inward rectifier potassium channel 8; Inward rectifier K(+) channel Kir6.1; Potassium channel, inwardly rectifying subfamily J member 8; uKATP-1", "protein_names_refseq": "ATP-sensitive inward rectifier potassium channel 8 isoform 1; ATP-sensitive inward rectifier potassium channel 8; inward rectifier K(+) channel Kir6.1; inwardly rectifier K(+) channel Kir6.1", "tax_id": 10090, "disease": "hypertrichotic osteochondrodysplasia Cantu type (Disease Ontology:DOID:0060569); Parkinsonism (Disease Ontology:DOID:0080855); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); coronary artery disease (Disease Ontology:DOID:3393)", "pathway": " (mmu:16523); (R-MMU-1296025)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11984590;21183079;21750661;9130167", "class_list": "", "function": "Gene disruption causes prinzmetal angina in knockout mice, [RefSeq, PubMed]; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium (By similarity). Can form a sulfonylurea-sensitive but ATP-insensitive potassium channel with ABCC9 (PubMed:9130167)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;GO:0005524 ATP binding;GO:0015272 ATP-activated inward rectifier potassium channel activity;GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity;GO:0017098 sulfonylurea receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0008282 inward rectifying potassium channel;GO:0042383 sarcolemma", "go_biological_process": "GO:0072359 circulatory system development;GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential;GO:0044546 NLRP3 inflammasome complex assembly;GO:0001774 microglial cell activation;GO:0002931 response to ischemia", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P97794-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0N1-1", "uniprot_id": [ { "id": "IF2G_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0N1", "type": "external" } ], "mass": 51065.0, "length": 472, "protein_name": "Eukaryotic translation initiation factor 2 subunit 3, X-linked", "gene_name": "Eif2s3x", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 2 subunit 3, X-linked", "refseq_ac": [ { "id": "NP_036140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036140", "type": "external" } ], "gene_names_uniprotkb": "Eif2s3x", "gene_names_refseq": "Eif-2gx; Eif2s3x; eIF-2-gamma X", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2 subunit 3, X-linked; 3.6.5.3; Eukaryotic translation initiation factor 2 subunit gamma, X-linked; eIF2-gamma X", "protein_names_refseq": "eIF2-gamma X; eukaryotic translation initiation factor 2 subunit 3, X-linked; eukaryotic translation initiation factor 2 subunit gamma, X-linked", "tax_id": 10090, "disease": "MEHMO syndrome (Disease Ontology:DOID:0060801); leukodystrophy (Disease Ontology:DOID:10579); glucose metabolism disease (Disease Ontology:DOID:4194); hypopituitarism (Disease Ontology:DOID:9406)", "pathway": " (mmu:26905); (R-MMU-156827); (R-MMU-381042); (R-MMU-382556); (R-MMU-72649); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-72731); (R-MMU-9840373)", "pathway_count": 10, "publication_count": 16, "publication_id_list": "12023983;16325480;17242355;21750661;25605945;26823431;28135057;28528544;29187734;32782141;35984892;37453647;37507081;37828378;39627609;9736774", "class_list": "", "function": "Eif2s3x is expressed higher in females than in males in developing and adult brains as well as adult liver, [RefSeq, PubMed]; Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (PubMed:26823431)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008135 translation factor activity, RNA binding;GO:0003743 translation initiation factor activity;GO:1990856 methionyl-initiator methionine tRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0005850 eukaryotic translation initiation factor 2 complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0006413 translational initiation;GO:0006446 regulation of translational initiation;GO:0001731 formation of translation preinitiation complex;GO:0007284 spermatogonial cell division", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9Z0N1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62482-1", "uniprot_id": [ { "id": "KCAB2_MOUSE", "url": "https://www.uniprot.org/uniprot/P62482", "type": "external" } ], "mass": 41021.0, "length": 367, "protein_name": "Voltage-gated potassium channel subunit beta-2", "gene_name": "Kcnab2", "organism": "Mouse", "refseq_name": "voltage-gated potassium channel subunit beta-2 isoform 1", "refseq_ac": [ { "id": "NP_001239585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239585", "type": "external" } ], "gene_names_uniprotkb": "Kcnab2; Ckbeta2; I2rf5; Kcnb3", "gene_names_refseq": "F5; I2rf5; Kcnab2; Kcnb3; kv-beta-2", "protein_names_uniprotkb": "Voltage-gated potassium channel subunit beta-2; 1.1.1.-; K(+) channel subunit beta-2; Kv-beta-2; Neuroimmune protein F5", "protein_names_refseq": "K(+) channel subunit beta-2; neuroimmune protein F5; voltage-gated potassium channel subunit beta-2 isoform 1; voltage-gated potassium channel subunit beta-2", "tax_id": 10090, "disease": "chromosome 1p36 deletion syndrome (Disease Ontology:DOID:0060410)", "pathway": " (mmu:16498); (R-MMU-1296072); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "11825900;15720404;1573677;21183079;21209188;21357749;21750661;24129315;26269648;29704886;31219806;31639389;33300544;33499656;34678516;35788155;8576199;8824288", "class_list": "", "function": "Genetic deletion of Kvbeta2 leads to decreased skeletal muscle size along with isotype switching from fast to slow fiber type., [RefSeq, PubMed]; Kvbeta2 subunits regulate the expression of myocardial Kv channels and confer redox sensitivity to Kv current and cardiac repolarization., [RefSeq, PubMed]; Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvbeta Proteins., [RefSeq, PubMed]; Regulatory subunit of the voltage-gated potassium (Kv) Shaker channel family. Shaker channels are composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:8576199). The beta-2/KCNAB2 subunit promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:8576199). Promotes the inactivation of Kv1.4/KCNA4 and Kv1.5/KCNA5 alpha subunit-containing channels (PubMed:8576199). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a wide range of aldehyde and ketone substrates (By similarity). Substrate specificity includes methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro, no physiological substrate identified yet) (By similarity). The binding of oxidized and reduced nucleotide cofactors alters Kv channel gating and may contribute to dynamic fine tuning of cell excitability (By similarity). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (PubMed:11825900, PubMed:21209188)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; The potassium channel auxiliary subunit Kvbeta2 (Kcnab2) regulates Kv1 channels and dopamine neuron firing., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97381;Q60942;Q64284", "ec_number_list": [ { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "1.1.1.189", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.189", "type": "external" }, { "id": "1.1.1.197", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.197", "type": "external" }, { "id": "1.1.1.196", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.196", "type": "external" }, { "id": "1.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.71", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.3.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.78", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.6.5.10", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.10", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.2", "type": "external" }, { "id": "1.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.-.-", "type": "external" }, { "id": "1.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.19", "type": "external" }, { "id": "1.1.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.20", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0044877 protein-containing complex binding;GO:0008106 alcohol dehydrogenase (NADP+) activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0034705 potassium channel complex;GO:0005829 cytosol;GO:0005874 microtubule;GO:0014069 postsynaptic density", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0050905 neuromuscular process;GO:0002244 hematopoietic progenitor cell differentiation;GO:2000008 regulation of protein localization to cell surface", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P62482-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PHZ8-1", "uniprot_id": [ { "id": "KCIP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PHZ8", "type": "external" } ], "mass": 28756.0, "length": 250, "protein_name": "Kv channel-interacting protein 4", "gene_name": "Kcnip4", "organism": "Mouse", "refseq_name": "Kv channel-interacting protein 4 isoform 1", "refseq_ac": [ { "id": "NP_001186171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186171", "type": "external" } ], "gene_names_uniprotkb": "Kcnip4; Calp; Kchip4", "gene_names_refseq": "Calp250; Calp; KChIP4a; KChIP4; Kcnip4", "protein_names_uniprotkb": "Kv channel-interacting protein 4; A-type potassium channel modulatory protein 4; Calsenilin-like protein; KChIP4; Potassium channel-interacting protein 4", "protein_names_refseq": "A-type potassium channel modulatory protein 4; Kv channel-interacting protein 4 isoform 1; calsenilin-like protein; kv channel-interacting protein 4; potassium channel interacting protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:80334); (R-MMU-5576894)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11805342;11847232;15363885;19109250;19713751;20045463;20943905;21183079;23457522", "class_list": "", "function": "Genome-wide association study identifies KCNIP4 as an asthma gene in human and in mouse., [RefSeq, PubMed]; KChIP4 was highly expressed by neurons in layers II-IV of cortex and in hippocampus, thalamus and the Purkinje cell layer of the cerebellum., [RefSeq, PubMed]; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3 (PubMed:19109250). Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6DTJ3;Q8CAD0;Q8R4I2;Q9EQ01", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005509 calcium ion binding;GO:0005267 potassium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0072659 protein localization to plasma membrane;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6PHZ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJ57-1", "uniprot_id": [ { "id": "KCIP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJ57", "type": "external" } ], "mass": 26831.0, "length": 227, "protein_name": "A-type potassium channel modulatory protein KCNIP1", "gene_name": "Kcnip1", "organism": "Mouse", "refseq_name": "A-type potassium channel modulatory protein KCNIP1 isoform A", "refseq_ac": [ { "id": "NP_001177814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177814", "type": "external" } ], "gene_names_uniprotkb": "Kcnip1; Kchip1", "gene_names_refseq": "KCHIP1; Kchip1.2; Kcnip1", "protein_names_uniprotkb": "A-type potassium channel modulatory protein KCNIP1; KChIP1; Kv channel-interacting protein 1; Potassium channel-interacting protein 1", "protein_names_refseq": "A-type potassium channel modulatory protein 1.2; A-type potassium channel modulatory protein KCNIP1 isoform A; A-type potassium channel modulatory protein KCNIP1; potassium channel-interacting protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70357); (R-MMU-5576894)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "14572458;15363885;17640927;19713751;21750661;34203471", "class_list": "", "function": "Aromatic cluster in exon1b modulates the transitions towards and from the closed inactivated states and the steady state distribution over the respective states, [RefSeq, PubMed]; Differential expression of KCh1P1 splice variants can shape the function of Kv4.2 channels involved in protection against back propagating action potentials in dendritic spines., [RefSeq, PubMed]; KChIP1 was expressed in a subpopulation of neurons widely distributed in brain and enriched in Purkinje cells of the cerebellum and in the reticular thalamic and medial habenular nuclei., [RefSeq, PubMed]; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels (PubMed:14572458). Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:14572458). Modulates KCND2/Kv4.2 currents (PubMed:14572458). In vitro, modulates KCND1/Kv4.1 currents (By similarity). Increases the presence of KCND2 at the cell surface., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SSA3;Q6DTJ1;Q8BGJ4;Q8C4K4;Q8CGL1;Q8K1U1;Q8K3M2", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding;GO:0005267 potassium channel activity", "go_cellular_component": "GO:0034705 potassium channel complex;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0045202 synapse", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0006936 muscle contraction;GO:0007268 chemical synaptic transmission;GO:0008016 regulation of heart contraction;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JJ57-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0V2-1", "uniprot_id": [ { "id": "KCND2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0V2", "type": "external" } ], "mass": 70577.0, "length": 630, "protein_name": "A-type voltage-gated potassium channel KCND2", "gene_name": "Kcnd2", "organism": "Mouse", "refseq_name": "A-type voltage-gated potassium channel KCND2", "refseq_ac": [ { "id": "NP_062671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062671", "type": "external" } ], "gene_names_uniprotkb": "Kcnd2; Kiaa1044; MNCb-7013", "gene_names_refseq": "Gm52855; Kcnd2; Kv4.2", "protein_names_uniprotkb": "A-type voltage-gated potassium channel KCND2; Potassium voltage-gated channel subfamily D member 2; Voltage-gated potassium channel subunit Kv4.2", "protein_names_refseq": "A-type voltage-gated potassium channel KCND2; potassium voltage-gated channel subfamily D member 2; voltage-gated potassium channel subunit Kv4.2", "tax_id": 10090, "disease": "", "pathway": " (mmu:16508); (R-MMU-1296072); (R-MMU-5576894)", "pathway_count": 3, "publication_count": 33, "publication_id_list": "10.1101/2023.09.13.557529;10601491;10681507;10818150;11040264;11606724;11909823;16009497;16251476;16293790;16600858;17122039;17122053;17917103;18045912;18187474;18357523;19713751;20371829;20857488;20943905;21183079;22098631;22311982;22612819;22738428;22815518;23713033;25541422;32218435;32824677;33300544;9734479", "class_list": "", "function": "Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in rodent heart. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (PubMed:10818150, PubMed:17122039, PubMed:18045912, PubMed:18187474, PubMed:20371829, PubMed:22815518). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites (PubMed:10818150, PubMed:17122039, PubMed:22815518). Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (PubMed:22815518). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (PubMed:18045912). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member (PubMed:10601491, PubMed:11909823, PubMed:23713033, PubMed:9734479). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:22311982, PubMed:9734479). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel (PubMed:11909823). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes (PubMed:11909823). Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (By similarity). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity (PubMed:22311982). Upon depolarization, the channel goes from a resting closed state (C state) to an activated but non-conducting state (C* state), from there, the channel may either inactivate (I state) or open (O state) (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BSK3;Q8CHB7;Q9JJ60", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0005267 potassium channel activity;GO:1905030 voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0034705 potassium channel complex;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006936 muscle contraction;GO:0019228 neuronal action potential;GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0019233 sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "Q9Z0V2-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PW8-1", "uniprot_id": [ { "id": "KIF17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PW8", "type": "external" } ], "mass": 116373.0, "length": 1038, "protein_name": "Kinesin-like protein KIF17", "gene_name": "Kif17", "organism": "Mouse", "refseq_name": "kinesin-like protein KIF17 isoform 1", "refseq_ac": [ { "id": "NP_034753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034753", "type": "external" } ], "gene_names_uniprotkb": "Kif17", "gene_names_refseq": "5930435E01Rik; Kif17b; Kif17; mKIAA1405", "protein_names_uniprotkb": "Kinesin-like protein KIF17; MmKIF17", "protein_names_refseq": "N-4 kinesin; kinesin 17; kinesin-like protein KIF17 isoform 1; kinesin-like protein KIF17", "tax_id": 10090, "disease": "", "pathway": " (mmu:16559); (R-MMU-5620924)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10846156;12391294;16787948;17196196;21750661;23810713;25243405;25428506;30458707;30696709;34203471;35678994;38669326", "class_list": "", "function": "Dual and opposing roles for the kinesin-2 motor, KIF17, in Hedgehog-dependent cerebellar development., [RefSeq, PubMed]; KIF17 Modulates Epileptic Seizures and Membrane Expression of the NMDA Receptor Subunit NR2B., [RefSeq, PubMed]; KIF17 contributes to neuronal events required for learning and memory by trafficking fundamental N-methyl-d-aspartate-type glutamate receptor, NR2A., [RefSeq, PubMed]; Phosphorylation of KIF17 promotes its photoreceptor outer segment localization and disc shedding, a process essential for photoreceptor maintenance and homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Results demonstrate that the Rab23-Kif17-cargo complex regulates tubulin acetylation for spindle organization and drives actin-mediated spindle migration during meiosis. Publication Status: Online-Only, [RefSeq, PubMed]; Together with RAB23 and IFT57, it is required for the localization of specific G protein-coupled receptors, such as dopamime receptor DRD1, to primary cilia to primary cilia (By similarity). In association with the Apba1-containing complex (LIN-10-LIN-2-LIN-7 complex), transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AM73;Q3V365", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity;GO:0008574 plus-end-directed microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005929 cilium;GO:0005871 kinesin complex", "go_biological_process": "GO:0015031 protein transport;GO:0016192 vesicle-mediated transport;GO:0030030 cell projection organization;GO:0042073 intraciliary transport;GO:0031503 protein-containing complex localization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q99PW8-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48025-1", "uniprot_id": [ { "id": "KSYK_MOUSE", "url": "https://www.uniprot.org/uniprot/P48025", "type": "external" } ], "mass": 71376.0, "length": 629, "protein_name": "Tyrosine-protein kinase SYK", "gene_name": "Syk", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase SYK", "refseq_ac": [ { "id": "NP_001185906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185906", "type": "external" } ], "gene_names_uniprotkb": "Syk; Sykb; ptk72", "gene_names_refseq": "Sykb; Syk", "protein_names_uniprotkb": "Tyrosine-protein kinase SYK; 2.7.10.2; Spleen tyrosine kinase", "protein_names_refseq": "tyrosine-protein kinase SYK", "tax_id": 10090, "disease": "immunodeficiency 82 (Disease Ontology:DOID:0061053); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780)", "pathway": " (mmu:20963); (R-MMU-114604); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-2424491); (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-354192); (R-MMU-5621480); (R-MMU-9020558); (R-MMU-912631); (R-MMU-9674555); (R-MMU-9705462); (R-MMU-9706374); (R-MMU-983695)", "pathway_count": 18, "publication_count": 47, "publication_id_list": "11672534;11940607;12077122;12522250;12771181;15143214;15536084;15845454;15956283;16174766;16410013;16456001;17086186;17353363;17947660;18369315;19098920;19124738;19219027;19339971;19797524;21183079;21750661;22496641;26195794;26495903;26891724;27609517;28011936;28716125;28722316;31089414;31249969;33782605;34428180;35753354;36210013;37813169;38904212;39261768;39627609;7477352;7477353;7513017;7538118;7639745;9171347", "class_list": "", "function": "Dectin1 contributes to hypertensive vascular injury by promoting macrophage infiltration through activating the Syk/NF-kappaB pathway., [RefSeq, PubMed]; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development (PubMed:33782605). Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR also plays a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade. Required for the stimulation of neutrophil phagocytosis by IL15 (By similarity). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (PubMed:19098920). Also functions downstream of receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Also plays a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (PubMed:26195794)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Phosphorylation of (Ser 291) in the linker insert of Syk negatively regulates ITAM signaling in platelets., [RefSeq, PubMed]; SYK promotes the formation of neutrophil extracellular traps by inducing PKM2 nuclear translocation and promoting STAT3 phosphorylation to exacerbate hepatic ischemia-reperfusion injury and tumor recurrence. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 33, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" } ], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0042101 T cell receptor complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0002366 leukocyte activation involved in immune response;GO:0032752 positive regulation of interleukin-3 production;GO:0002283 neutrophil activation involved in immune response;GO:0002554 serotonin secretion by platelet", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "P48025-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05532-1", "uniprot_id": [ { "id": "KIT_MOUSE", "url": "https://www.uniprot.org/uniprot/P05532", "type": "external" } ], "mass": 109343.0, "length": 979, "protein_name": "Mast/stem cell growth factor receptor Kit", "gene_name": "Kit", "organism": "Mouse", "refseq_name": "mast/stem cell growth factor receptor Kit isoform 1 precursor", "refseq_ac": [ { "id": "NP_001116205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116205", "type": "external" } ], "gene_names_uniprotkb": "Kit; Sl", "gene_names_refseq": "Bs; CD117; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; Kit; SCO1; SCO5; SOW3; Ssm; Tr-kit; W; c-KIT", "protein_names_uniprotkb": "Mast/stem cell growth factor receptor Kit; 2.7.10.1; Proto-oncogene c-Kit; SCFR; Tyrosine-protein kinase Kit", "protein_names_refseq": "Dominant white spotting; SCFR; Steel Factor Receptor; belly-spot; c-kit proto-oncogene protein; dominant spotting; kit oncogene; mast/stem cell growth factor receptor Kit isoform 1 precursor; mast/stem cell growth factor receptor Kit; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; spotted sterile male", "tax_id": 10090, "disease": "Hirschsprung's disease (Disease Ontology:DOID:10487); gastroschisis (Disease Ontology:DOID:11044); urinary bladder cancer (Disease Ontology:DOID:11054); male infertility (Disease Ontology:DOID:12336); aplastic anemia (Disease Ontology:DOID:12449); melanoma (Disease Ontology:DOID:1909); leiomyosarcoma (Disease Ontology:DOID:1967); nephroblastoma (Disease Ontology:DOID:2154); macrocytic anemia (Disease Ontology:DOID:2361); acute pancreatitis (Disease Ontology:DOID:2913); granulosa cell tumor (Disease Ontology:DOID:2999); invasive ductal carcinoma (Disease Ontology:DOID:3008); interstitial lung disease (Disease Ontology:DOID:3082); piebaldism (Disease Ontology:DOID:3263); mastocytosis (Disease Ontology:DOID:350); endometrial stromal sarcoma (Disease Ontology:DOID:4226); seminoma (Disease Ontology:DOID:4440); dysgerminoma (Disease Ontology:DOID:4441); renal cell carcinoma (Disease Ontology:DOID:4450); cholangiocarcinoma (Disease Ontology:DOID:4947); oxyphilic adenoma (Disease Ontology:DOID:5389); uterine carcinosarcoma (Disease Ontology:DOID:6171); ileus (Disease Ontology:DOID:8440); acute myeloid leukemia (Disease Ontology:DOID:9119); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); neurofibroma (Disease Ontology:DOID:962)", "pathway": " (mmu:16590); (R-MMU-1257604); (R-MMU-1433557); (R-MMU-1433559); (R-MMU-5673001); (R-MMU-6811558); (R-MMU-9856649)", "pathway_count": 7, "publication_count": 28, "publication_id_list": "10.1101/2023.09.13.557529;12558531;1378413;15731517;1688471;1693331;1698611;1709486;1714377;17255936;17595334;17947660;18447649;18725415;20200353;21037083;21183079;2456920;26495903;26740625;32554613;33300544;35820727;7509796;7527401;7682073;9528781;9722617", "class_list": "", "function": "The c-Kit proto-oncogene is the cellular homolog of the transforming gene of a feline retrovirus (v-Kit). The c-kit protein includes characteristics of a protein kinase transmembrane receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 26, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q61415;Q61416;Q61417;Q6LEE9;Q6QJB7;Q6QJB8;Q7TS86;Q8C8K9", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "6.1.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.10", "type": "external" }, { "id": "6.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.4", "type": "external" }, { "id": "6.1.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.18", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "6.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.6", "type": "external" }, { "id": "6.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.19", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" } ], "go_molecular_function": "GO:0002020 protease binding;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0009986 cell surface;GO:0043235 receptor complex", "go_biological_process": "GO:0002318 myeloid progenitor cell differentiation;GO:0002573 myeloid leukocyte differentiation;GO:1904349 positive regulation of small intestine smooth muscle contraction;GO:0002327 immature B cell differentiation;GO:0035162 embryonic hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "P05532-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100100010001.111.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97414-1", "uniprot_id": [ { "id": "KCNQ1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97414", "type": "external" } ], "mass": 74514.0, "length": 668, "protein_name": "Potassium voltage-gated channel subfamily KQT member 1", "gene_name": "Kcnq1", "organism": "Mouse", "refseq_name": "potassium voltage-gated channel subfamily KQT member 1 isoform 1", "refseq_ac": [ { "id": "NP_032460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032460", "type": "external" } ], "gene_names_uniprotkb": "Kcnq1; Kcna9; Kvlqt1", "gene_names_refseq": "KVLQT1; Kcna9; Kcnq1", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily KQT member 1; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Voltage-gated potassium channel subunit Kv7.1", "protein_names_refseq": "IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; potassium voltage-gated channel subfamily KQT member 1 isoform 1; potassium voltage-gated channel subfamily KQT member 1; voltage-gated potassium channel subunit Kv7.1", "tax_id": 10090, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); short QT syndrome (Disease Ontology:DOID:0050793); atrial fibrillation (Disease Ontology:DOID:0060224); long QT syndrome 1 (Disease Ontology:DOID:0110644); hypertension (Disease Ontology:DOID:10763); Jervell-Lange Nielsen syndrome (Disease Ontology:DOID:2842); long QT syndrome (Disease Ontology:DOID:2843); seminoma (Disease Ontology:DOID:4440); Beckwith-Wiedemann syndrome (Disease Ontology:DOID:5572); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:16535); (R-MMU-1296072); (R-MMU-5576890); (R-MMU-5576893)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "11120752;15004216;16314573;17021040;17597584;19491250;21183079;21750661;24595108;38857404;8900282;9618174", "class_list": "", "function": "KCNQ1 is an essential mediator of the sex-dependent perception of moderate cold temperatures., [RefSeq, PubMed]; Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of cardiomyocyte excitability and important in normal development and functions of myocardium, inner ear, stomach and colon (By similarity) (PubMed:11120752, PubMed:15004216, PubMed:16314573). Associates with KCNE beta subunits that modulates current kinetics (By similarity) (PubMed:15004216, PubMed:17597584). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity) (PubMed:8900282). Also promotes a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) (PubMed:15004216, PubMed:17597584). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (By similarity). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (By similarity). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (PubMed:16314573). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (PubMed:19491250). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (By similarity). When associated with KCNE4, inhibits voltage-gated potassium channel activity (By similarity). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (By similarity). Also forms a heterotetramer with KCNQ5; has a voltage-gated potassium channel activity (By similarity). Binds with phosphatidylinositol 4,5-bisphosphate (By similarity). KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (PubMed:24595108)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed, PubMed]; Repression of the paternal allele of several imprinted genes (including Kcnq1) on distal chromosome 7 is regulated by a non-coding antisense transcript, Kcnq1ot1, which is paternally expressed., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O88702;Q3U4H1;Q7TNZ1;Q7TPL7;Q80VR7", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization;GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization;GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;GO:0034236 protein kinase A catalytic subunit binding", "go_cellular_component": "GO:0034705 potassium channel complex;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0060453 regulation of gastric acid secretion;GO:0086011 membrane repolarization during action potential;GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential;GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential;GO:1903817 negative regulation of voltage-gated potassium channel activity", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P97414-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C078-1", "uniprot_id": [ { "id": "KKCC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C078", "type": "external" } ], "mass": 64618.0, "length": 588, "protein_name": "Calcium/calmodulin-dependent protein kinase kinase 2", "gene_name": "Camkk2", "organism": "Mouse", "refseq_name": "calcium/calmodulin-dependent protein kinase kinase 2 isoform 1", "refseq_ac": [ { "id": "NP_001186605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186605", "type": "external" } ], "gene_names_uniprotkb": "Camkk2; Kiaa0787", "gene_names_refseq": "6330570N16Rik; Camkk2; mKIAA0787", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase kinase 2; 2.7.11.17; CaM-KK 2; CaM-KK beta; CaM-kinase kinase 2; CaM-kinase kinase beta; CaMKK 2; CaMKK beta; Calcium/calmodulin-dependent protein kinase kinase beta", "protein_names_refseq": "caM-KK 2; caM-KK beta; caM-kinase kinase 2; caM-kinase kinase beta; caMKK 2; caMKK beta; calcium/calmodulin-dependent protein kinase kinase 2 isoform 1; calcium/calmodulin-dependent protein kinase kinase beta", "tax_id": 10090, "disease": "high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (mmu:207565); (R-MMU-111932); (R-MMU-442729); (R-MMU-9619229)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "12654522;14586002;17114649;17242355;21183079;21750661;34428180;38110408;38703937;38755664", "class_list": "", "function": "Aberrant expression of NEDD4L disrupts mitochondrial homeostasis by downregulating CaMKKbeta in diabetic kidney disease. Publication Status: Online-Only, [RefSeq, PubMed]; Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK4 and CAMK1D (By similarity). Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). May play a role in neurite growth. Isoform 2 may promote neurite elongation, while isoform 1 may promoter neurite branching (By similarity). May be involved in hippocampal activation of CREB1., [UniProtKB, PubMed]; Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Conditional loss of CaMKK2 in Osterix-positive osteoprogenitors enhances osteoblast function in a sex-divergent manner., [RefSeq, PubMed]; Findings suggest CaM kinase kinase beta isoforms are required for the formation of hippocampal long-term memory[LTM], but not needed for contextual, trace fear, and passive avoidance LTM, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80TS0;Q8BXM8;Q8C0G3;Q8CH42;Q8QZT7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005509 calcium ion binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0043005 neuron projection", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0032147 activation of protein kinase activity;GO:0046777 protein autophosphorylation;GO:0061762 CAMKK-AMPK signaling cascade;GO:1903599 positive regulation of autophagy of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8C078-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNC6-1", "uniprot_id": [ { "id": "KI26B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TNC6", "type": "external" } ], "mass": 225511.0, "length": 2112, "protein_name": "Kinesin-like protein KIF26B", "gene_name": "Kif26b", "organism": "Mouse", "refseq_name": "kinesin-like protein KIF26B", "refseq_ac": [ { "id": "NP_001155137", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155137", "type": "external" } ], "gene_names_uniprotkb": "Kif26b", "gene_names_refseq": "4832420M10; D230039L06Rik; Kif26b", "protein_names_uniprotkb": "Kinesin-like protein KIF26B", "protein_names_refseq": "N-11 kinesin; kinesin family protein 26b; kinesin-like protein KIF26B", "tax_id": 10090, "disease": "", "pathway": " (mmu:269152); (R-MMU-6811434); (R-MMU-983189)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;14727108;20439720;21750661;22768111;34428180;34787331;35066304;36250931", "class_list": "", "function": "Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules., [UniProtKB, PubMed, PubMed]; KIF26B Silencing Prevents Osseous Transdifferentiation of Progenitor/Stem Cells and Attenuates Ectopic Calcification in a Murine Model., [RefSeq, PubMed]; KIF26B may play a role in embryogenesis, specifically in the development of limbs, face, and somites, [RefSeq, PubMed]; Kif26b contributes to the progression of interstitial fibrosis via migration and myofibroblast differentiation in renal fibroblast., [RefSeq, PubMed]; Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme., [RefSeq, PubMed]; Novel mechanistic role of Kif26b in adipogenic differentiation of murine multipotent stromal cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D5MP63;E9PXV6;Q0VB48;Q8BHX2;Q8BKH6", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0072092 ureteric bud invasion;GO:0007018 microtubule-based movement;GO:0030010 establishment of cell polarity;GO:0048731 system development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7TNC6-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UVC0-1", "uniprot_id": [ { "id": "KSR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UVC0", "type": "external" } ], "mass": 107655.0, "length": 951, "protein_name": "Kinase suppressor of Ras 2", "gene_name": "Ksr2", "organism": "Mouse", "refseq_name": "kinase suppressor of Ras 2", "refseq_ac": [ { "id": "NP_001299843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299843", "type": "external" } ], "gene_names_uniprotkb": "Ksr2", "gene_names_refseq": "Ksr2", "protein_names_uniprotkb": "Kinase suppressor of Ras 2; 2.7.11.1", "protein_names_refseq": "kinase suppressor of Ras 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:333050); (R-MMU-5674135)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;19560418;19883615;21127480;21183079;21750661;22645316;22801368;27561547;32848054;36342465;40885482", "class_list": "", "function": "Contrasting effects of Ksr2, an obesity gene, on trabecular bone volume and bone marrow adiposity. Publication Status: Online-Only, [RefSeq, PubMed]; KSR2 is essential to tumor cell energy homeostasis and critical to the integration of mitogenic and metabolic signaling pathways, [RefSeq, PubMed]; KSR2 regulates AMPK-dependent glucose uptake and fatty acid oxidation in mouse embryonic fibroblasts and glycolysis in a neuronal cell line., [RefSeq, PubMed]; Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1. Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production., [UniProtKB, UniProtKB]; The metabolic phenotype of KSR2 heterozygous (KSR2(+/minus;)) and KSR2(-/-) mice suggests that human KSR2 variants may contribute to a similar phenotype linked to human chromosome 12q24, [RefSeq, PubMed]; The protein phosphatase calcineurin selectively interacts with KSR2 and KSR2 uniquely contributes to Ca2+-mediated ERK signaling., [RefSeq, PubMed]; These data indicate that KSR2 functions in a cell non-autonomous fashion to regulate GH-stimulated IGF-1 expression in the liver of neonatal mice, which plays a key role in the development of body length. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "M0QW59", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0031434 mitogen-activated protein kinase kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0043410 positive regulation of MAPK cascade;GO:0007265 Ras protein signal transduction;GO:0120162 positive regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q3UVC0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SWP3-1", "uniprot_id": [ { "id": "NACAD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SWP3", "type": "external" } ], "mass": 156764.0, "length": 1504, "protein_name": "NAC-alpha domain-containing protein 1", "gene_name": "Nacad", "organism": "Mouse", "refseq_name": "NAC-alpha domain-containing protein 1", "refseq_ac": [ { "id": "NP_001075121", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075121", "type": "external" } ], "gene_names_uniprotkb": "Nacad; Kiaa0363", "gene_names_refseq": "D230024G13Rik; Nacad; mKIAA0363", "protein_names_uniprotkb": "NAC-alpha domain-containing protein 1", "protein_names_refseq": "NAC-alpha domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:192950)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;22517741;22872234;25428506;35820727;40021952;40885482", "class_list": "", "function": "May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q6I6F5", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0051082 unfolded protein binding;GO:0017025 TBP-class protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005854 nascent polypeptide-associated complex", "go_biological_process": "GO:0015031 protein transport;GO:0006612 protein targeting to membrane;GO:0051451 myoblast migration", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q5SWP3-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CCN1-1", "uniprot_id": [ { "id": "NAL10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CCN1", "type": "external" } ], "mass": 76367.0, "length": 673, "protein_name": "NACHT, LRR and PYD domains-containing protein 10", "gene_name": "Nlrp10", "organism": "Mouse", "refseq_name": "NACHT, LRR and PYD domains-containing protein 10", "refseq_ac": [ { "id": "NP_780741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780741", "type": "external" } ], "gene_names_uniprotkb": "Nlrp10; Nalp10; Pynod", "gene_names_refseq": "6430548I20Rik; Nalp10; Napl10; Nlrp10; PAN5; Pynod", "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 10", "protein_names_refseq": "NACHT, LRR and PYD containing protein 10; NACHT, LRR and PYD domains-containing protein 10; NACHT, leucine rich repeat and PYD containing 10; NACHT/LRR/pyrin domain-containing protein 10; neuronal apoptosis inhibitor protein 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:244202)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "15096476;15817483;20393137;22538615;23071280;27221772;29501574;30084848;30510071;32084391;35820727", "class_list": "", "function": "Authors observed an important role of NLRP10 in cytokine and chemokine production as well as expression of NF-kappaB and MAPKs in CSE-exposed A549 cells. Furthermore, replenishment of A549 cell culture with recombinant IL-17A (rIL-17A) during NLRP10 knockdown rescued CSE-induced inflammatory responses., [RefSeq, PubMed]; Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (By similarity). Displays anti-inflammatory activity (By similarity). Required for immunity against C.albicans infection (PubMed:23071280). Involved in the innate immune response by contributing to pro-inflammatory cytokine release in response to invasive bacterial infection (By similarity). Contributes to T-cell-mediated inflammatory responses in the skin (PubMed:27221772). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (By similarity). Exhibits both ATPase and GTPase activities (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; NLRP10 ablation protects against ischemia/reperfusion-associated brain injury by suppression of neuroinflammation., [RefSeq, PubMed]; PYPAF3 is a feedback regulator of interleukin-1beta secretion, and PYPAF2 and PYPAF3, together with PYNOD, constitute an anti-inflammatory subgroup of PYRIN-containing apoptotic protease-activating factor-1-like proteins, [RefSeq, PubMed]; This study shows that NLRP10 affects the stability of Abin-1 to control inflammatory responses, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0032730 positive regulation of interleukin-1 alpha production;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0032755 positive regulation of interleukin-6 production;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8CCN1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D3X5-1", "uniprot_id": [ { "id": "PACRL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D3X5", "type": "external" } ], "mass": 27290.0, "length": 248, "protein_name": "PACRG-like protein", "gene_name": "5730480H06Rik; Pacrgl", "organism": "Mouse", "refseq_name": "PACRG-like protein", "refseq_ac": [ { "id": "NP_080031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080031", "type": "external" } ], "gene_names_uniprotkb": "5730480H06Rik; Pacrgl", "gene_names_refseq": "4933428G09Rik; Pacrgl", "protein_names_uniprotkb": "PACRG-like protein", "protein_names_refseq": "PACRG-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:66768)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D3X5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24610-1", "uniprot_id": [ { "id": "PAX3_MOUSE", "url": "https://www.uniprot.org/uniprot/P24610", "type": "external" } ], "mass": 52949.0, "length": 479, "protein_name": "Paired box protein Pax-3", "gene_name": "Pax3", "organism": "Mouse", "refseq_name": "paired box protein Pax-3 isoform b", "refseq_ac": [ { "id": "NP_001152992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152992", "type": "external" } ], "gene_names_uniprotkb": "Pax3; Pax-3", "gene_names_refseq": "Pax-3; Pax3; Splchl2; Sp; splotch", "protein_names_uniprotkb": "Paired box protein Pax-3", "protein_names_refseq": "PAX3/FKHR fusion; paired box gene 3; paired box protein Pax-3 isoform b; paired box protein Pax-3", "tax_id": 10090, "disease": "neural tube defect (Disease Ontology:DOID:0080074); Waardenburg syndrome type 1 (Disease Ontology:DOID:0110948); Waardenburg syndrome type 3 (Disease Ontology:DOID:0110949); craniofacial-deafness-hand syndrome (Disease Ontology:DOID:0111336); prostate cancer (Disease Ontology:DOID:10283); alveolar rhabdomyosarcoma (Disease Ontology:DOID:4051); Waardenburg syndrome (Disease Ontology:DOID:9258)", "pathway": " (mmu:18505); (R-MMU-3214847)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "1682057;18644785;18708529;19904978;2022185;22862948;27906130;8406487", "class_list": "", "function": "Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFQ9;Q8BRE7;Q9CXI6", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0060538 skeletal muscle organ development;GO:0060594 mammary gland specification;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P24610-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P2K6-1", "uniprot_id": [ { "id": "P4R3A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P2K6", "type": "external" } ], "mass": 93842.0, "length": 820, "protein_name": "Serine/threonine-protein phosphatase 4 regulatory subunit 3A", "gene_name": "Ppp4r3a", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform 2", "refseq_ac": [ { "id": "NP_001153686", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153686", "type": "external" } ], "gene_names_uniprotkb": "Ppp4r3a; Kiaa2010; Pp4r3a; Smek1", "gene_names_refseq": "1110034C04Rik; Ppp4r3a; Smek1; mKIAA2010", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 4 regulatory subunit 3A; SMEK homolog 1", "protein_names_refseq": "SMEK homolog 1, suppressor of mek1; serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform 2; serine/threonine-protein phosphatase 4 regulatory subunit 3A", "tax_id": 10090, "disease": "", "pathway": " (mmu:68734)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;17242355;18630941;19131326;21183079;21750661;23806337;29180410;30084848;34183017;34418053;34428180;35314861;38568153;39206808;39627609", "class_list": "", "function": "Loss of Smek1 Induces Tauopathy and Triggers Neurodegeneration by Regulating Microtubule Stability., [RefSeq, PubMed]; Ppp4r3a deficiency leads to depression-like behaviors in mice by modulating the synthesis of synaptic proteins., [RefSeq, PubMed]; Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair (By similarity)., [UniProtKB]; SMEK1 ablation promotes glucose uptake and improves obesity-related metabolic dysfunction via AMPK signaling pathway., [RefSeq, PubMed]; Smek1 and Smek2 (Smek1/2) are key factors in the Ryk signaling pathway, [RefSeq, PubMed]; Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway. Erratum:[J Neuroinflammation. 2023 Jul 6;20(1):160. doi: 10.1186/s12974-023-02834-6. PMID: 37407996] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UF79;Q69Z35;Q80VS2;Q8BKP7", "ec_number_list": [], "go_molecular_function": "GO:0072542 protein phosphatase activator activity;GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0006974 DNA damage response;GO:0006470 protein dephosphorylation;GO:0045722 positive regulation of gluconeogenesis;GO:2000779 regulation of double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q6P2K6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K212-1", "uniprot_id": [ { "id": "PACS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K212", "type": "external" } ], "mass": 104829.0, "length": 961, "protein_name": "Phosphofurin acidic cluster sorting protein 1", "gene_name": "Pacs1", "organism": "Mouse", "refseq_name": "phosphofurin acidic cluster sorting protein 1 isoform 1", "refseq_ac": [ { "id": "NP_694769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694769", "type": "external" } ], "gene_names_uniprotkb": "Pacs1", "gene_names_refseq": "Pacs1", "protein_names_uniprotkb": "Phosphofurin acidic cluster sorting protein 1; PACS-1", "protein_names_refseq": "cytosolic sorting protein PACS-1; phosphofurin acidic cluster sorting protein 1 isoform 1", "tax_id": 10090, "disease": "Schuurs-Hoeijmakers Syndrome (Disease Ontology:DOID:0070047)", "pathway": " (mmu:107975)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;15692563;16308564;21183079;21750661;30458990;31219806;33300544;33630350;34428180;35820727;40885482;9695949", "class_list": "", "function": "Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases., [RefSeq, PubMed]; Casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia, [RefSeq, PubMed]; Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits (By similarity). Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (PubMed:33630350)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; The roles of the phosphofurin acidic cluster sorting protein - 1 (PACS-1) and the clathrin adaptor protein 1 (AP-1) in the targeting of Pro-opiomelanocortin to dense core secretory granules., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6P5H8", "ec_number_list": [], "go_molecular_function": "GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm;GO:0030137 COPI-coated vesicle", "go_biological_process": "GO:0002260 lymphocyte homeostasis;GO:0072659 protein localization to plasma membrane;GO:0034067 protein localization to Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8K212-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CY58-1", "uniprot_id": [ { "id": "SERB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CY58", "type": "external" } ], "mass": 44714.0, "length": 407, "protein_name": "SERPINE1 mRNA-binding protein 1", "gene_name": "Serbp1", "organism": "Mouse", "refseq_name": "SERPINE1 mRNA-binding protein 1 isoform 3", "refseq_ac": [ { "id": "NP_001107037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107037", "type": "external" } ], "gene_names_uniprotkb": "Serbp1; Pairbp1", "gene_names_refseq": "1200009K13Rik; 9330147J08Rik; Pairbp1; Serbp1", "protein_names_uniprotkb": "SERPINE1 mRNA-binding protein 1; PAI-RBP1; PAI1 RNA-binding protein 1; Plasminogen activator inhibitor 1 RNA-binding protein", "protein_names_refseq": "PAI-1 mRNA-binding protein; PAI-RBP1; PAI1 RNA-binding protein 1; SERPINE1 mRNA-binding protein 1 isoform 3; SERPINE1 mRNA-binding protein 1; plasminogen activator inhibitor 1 RNA-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:66870)", "pathway_count": 1, "publication_count": 30, "publication_id_list": "15345747;17242355;18440126;19131326;19144319;21183079;21750661;22645316;23806337;23894536;24129315;25428506;25605945;28528544;30084848;30779550;31599954;32762776;33649389;34428180;34723832;34815424;34887587;35820727;35984892;36288343;37453647;37507081;37828378;39927985", "class_list": "", "function": "MiR-23a/b-3p promotes hepatic lipid accumulation by regulating Srebp-1c and Fas. Publication Status: Online-Only, [RefSeq, PubMed]; Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:34815424). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (PubMed:34815424). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (By similarity). Seems to play a role in PML-nuclear bodies formation (By similarity)., [UniProtKB, UniProtKB, PubMed]; The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation. Publication Status: Online-Only, [RefSeq, PubMed]; The aim of this study was to assess the expression, localization and hormonal regulation of two novel P(4) receptor candidates, P(4) receptor membrane component (PGRMC) 1 and PGRMC2, as well as the PGRMC1 partner Serpine 1 mRNA binding protein (SERBP1)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHS2;Q8BHU0;Q91WP3;Q9CSN0;Q9DBY6", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0030371 translation repressor activity;GO:0043022 ribosome binding;GO:0003730 mRNA 3'-UTR binding;GO:0061770 translation elongation factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0030578 PML body organization;GO:0017148 negative regulation of translation;GO:0042981 regulation of apoptotic process;GO:0141014 ribosome hibernation;GO:0006417 regulation of translation", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q9CY58-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVE8-1", "uniprot_id": [ { "id": "PACN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVE8", "type": "external" } ], "mass": 55833.0, "length": 486, "protein_name": "Protein kinase C and casein kinase substrate in neurons protein 2", "gene_name": "Pacsin2", "organism": "Mouse", "refseq_name": "protein kinase C and casein kinase substrate in neurons protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001152981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152981", "type": "external" } ], "gene_names_uniprotkb": "Pacsin2", "gene_names_refseq": "Pacsin2; SdpII", "protein_names_uniprotkb": "Protein kinase C and casein kinase substrate in neurons protein 2; SdpII; Syndapin-2; Syndapin-II", "protein_names_refseq": "Syndapin II; protein kinase C and casein kinase substrate in neurons protein 2 isoform 1; protein kinase C and casein kinase substrate in neurons protein 2; syndapin-2; syndapin-II", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:23970); (R-MMU-8856828)", "pathway_count": 2, "publication_count": 29, "publication_id_list": "10.1101/2023.09.13.557529;10431838;11082044;15930129;16627472;20188097;20471395;21183079;21610094;21693584;21750661;21807942;22872234;23129763;23806337;25605945;26092940;26495903;31219806;33972531;34203471;34325130;34428180;34990060;36210013;36288343;37453647;37678551;40684658", "class_list": "", "function": "Dynamin 2 and BAR domain protein pacsin 2 cooperatively regulate formation and maturation of podosomes., [RefSeq, PubMed]; PACSIN proteins in vivo: Roles in development and physiology. Review article, [RefSeq, PubMed]; PACSIN2 regulates platelet integrin beta1 hemostatic function., [RefSeq, PubMed]; Regulates the morphogenesis and endocytosis of caveolae (PubMed:21807942). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (PubMed:33972531)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0008289 lipid binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:0072584 caveolin-mediated endocytosis;GO:0045806 negative regulation of endocytosis;GO:0007165 signal transduction;GO:0030100 regulation of endocytosis;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q9WVE8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23798-1", "uniprot_id": [ { "id": "PCGF2_MOUSE", "url": "https://www.uniprot.org/uniprot/P23798", "type": "external" } ], "mass": 37723.0, "length": 342, "protein_name": "Polycomb group RING finger protein 2", "gene_name": "Pcgf2", "organism": "Mouse", "refseq_name": "polycomb group RING finger protein 2", "refseq_ac": [ { "id": "NP_001156779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156779", "type": "external" } ], "gene_names_uniprotkb": "Pcgf2; Mel-18; Mel18; Rnf110; Zfp144; Znf144", "gene_names_refseq": "Mel18; Pcgf2; Rnf110; Zfp144; mel-18", "protein_names_uniprotkb": "Polycomb group RING finger protein 2; DNA-binding protein Mel-18; Melanoma nuclear protein 18; RING finger protein 110; Zfp-144; Zinc finger protein 144", "protein_names_refseq": "DNA-binding protein Mel-18; melanoma nuclear protein 18; polycomb group RING finger protein 2; ring finger protein 110; zfp-144; zinc finger protein 144", "tax_id": 10090, "disease": "", "pathway": " (mmu:22658); (R-MMU-3108214); (R-MMU-3899300); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-8953750)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "11471062;11750047;12480532;15183898;15728456;16024804;21750661;22226355;2246278;34428180;8521824;8625838", "class_list": "", "function": "Transcriptional repressor (PubMed:8521824). Binds specifically to the DNA sequence 5'-GACTNGACT-3' (PubMed:8521824). Has tumor suppressor activity (PubMed:8521824). May play a role in control of cell proliferation and/or neural cell development (Probable). Regulates proliferation of early T progenitor cells by maintaining expression of HES1 (PubMed:15728456). Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (PubMed:15183898, PubMed:8625838). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000785 chromatin;GO:0031519 PcG protein complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P23798-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VE70-1", "uniprot_id": [ { "id": "PDC10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VE70", "type": "external" } ], "mass": 24716.0, "length": 212, "protein_name": "Programmed cell death protein 10", "gene_name": "Pdcd10", "organism": "Mouse", "refseq_name": "programmed cell death protein 10", "refseq_ac": [ { "id": "NP_062719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062719", "type": "external" } ], "gene_names_uniprotkb": "Pdcd10; Tfar15", "gene_names_refseq": "2410003B13Rik; Ccm3; Pdcd10; Tfa15; Tfar15", "protein_names_uniprotkb": "Programmed cell death protein 10; TF-1 cell apoptosis-related protein 15", "protein_names_refseq": "TF-1 cell apoptosis-related protein 15; programmed cell death protein 10", "tax_id": 10090, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669); cerebral cavernous malformation 3 (Disease Ontology:DOID:0060671); varicocele (Disease Ontology:DOID:12337); hepatitis (Disease Ontology:DOID:2237); endometrial adenocarcinoma (Disease Ontology:DOID:2870); liver cirrhosis (Disease Ontology:DOID:5082); liver carcinoma (Disease Ontology:DOID:686)", "pathway": " (mmu:56426)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20371769;21750661;31219806;35741725;38293758", "class_list": "", "function": "Cerebral cavernous malformation proteins, CCM1, CCM2 and CCM3, are decreased in metastatic lesions in a murine breast carcinoma model., [RefSeq, PubMed]; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (By similarity). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown (PubMed:20371769). Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity)., [UniProtKB, PubMed, UniProtKB]; Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 (also known as PDCD10) is critical for vascular development. Erratum:[Sci Signal. 2010;3(121):er4] Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptome Analysis Reveals Altered Expression of Genes Involved in Hypoxia, Inflammation and Immune Regulation in Pdcd10-Depleted Mouse Endothelial Cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DAR3;Q9WV43", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0071454 cellular response to anoxia;GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VE70-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IMP4-1", "uniprot_id": [ { "id": "PANX2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6IMP4", "type": "external" } ], "mass": 74614.0, "length": 677, "protein_name": "Pannexin-2", "gene_name": "Panx2", "organism": "Mouse", "refseq_name": "pannexin-2", "refseq_ac": [ { "id": "NP_001002005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002005", "type": "external" } ], "gene_names_uniprotkb": "Panx2", "gene_names_refseq": "Panx2", "protein_names_uniprotkb": "Pannexin-2", "protein_names_refseq": "pannexin-2", "tax_id": 10090, "disease": "cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (mmu:406218); (R-MMU-112303)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "15028292;16143426;16616526;17149368;18695503;20529862;21183079;21750661;28390953;30059200;30899004;32848054;34985913", "class_list": "", "function": "Data show that Panx2 is expressed in the spiral and Scarpa's ganglion neurons., [RefSeq, PubMed]; Despite similarity in detergent solubility of pannexins and connexins, the lack of spatial co-localization in the lens membranes suggested a distinct, non-redundant to connexin function for these proteins in the lens cell membrane. Publication Status: Online-Only, [RefSeq, PubMed]; Ion channel with a slight anion preference. Also able to release ATP (By similarity). Plays a role in regulating neurogenesis and apoptosis in keratinocytes (PubMed:20529862, PubMed:34985913)., [UniProtKB, UniProtKB, PubMed, PubMed]; Pannexin 2 is expressed in murine skin and promotes UVB-induced apoptosis of keratinocytes., [RefSeq, PubMed]; Panx1 and Panx2 are abundantly expressed in the retina, and may therefore contribute to the electrical and metabolic coupling, or to signaling between retinal neurons, [RefSeq, PubMed]; Panx2 is an important regulator of the insulin secretory capacity and apoptosis in pancreatic beta-cells., [RefSeq, PubMed]; Results reveal a widespread and similar mRNA distribution for both pannexin 1 and 2, but indicate that they are inversely regulated during the development of the rat brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B1PL20;Q4JGM2", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005198 structural molecule activity;GO:0044877 protein-containing complex binding;GO:0022829 wide pore channel activity;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0002931 response to ischemia;GO:0007267 cell-cell signaling;GO:0034220 monoatomic ion transmembrane transport;GO:0006812 monoatomic cation transport;GO:0032732 positive regulation of interleukin-1 production", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q6IMP4-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXV0-1", "uniprot_id": [ { "id": "PCS1N_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXV0", "type": "external" } ], "mass": 27270.0, "length": 258, "protein_name": "ProSAAS", "gene_name": "Pcsk1n", "organism": "Mouse", "refseq_name": "proSAAS precursor", "refseq_ac": [ { "id": "NP_038920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038920", "type": "external" } ], "gene_names_uniprotkb": "Pcsk1n", "gene_names_refseq": "KEP; PEN19; PEN20; PEN; Pan3; Pcsk1n; SAASCT; SAAS; bLEN; lLEN; proSAAS", "protein_names_uniprotkb": "ProSAAS; BigLEN; IA-4; Proprotein convertase 1 inhibitor; Proprotein convertase subtilisin/kexin type 1 inhibitor; SAAS CT(1-49); SAAS CT(25-40); pro-SAAS", "protein_names_refseq": "IA-4; basic protein IA-4; big PEN LEN; big SAAS; granin-like neuroendocrine peptide; little LEN; little SAAS; pancreas protein 3; pro-SAAS; proSAAS precursor; proprotein convertase 1 inhibitor; protein serine alanine alanine serine", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); dementia (Disease Ontology:DOID:1307); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:30052)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10632593;11094058;11259501;11719503;11742530;15018810;16631141;22872234;24043826;26192747;27117253;30084848;32607937;34203471;35878875;9630436;9756897", "class_list": "", "function": "Endogenous ligand for GPR171 (PubMed:24043826). Neuropeptide involved in the regulation of feeding (PubMed:24043826)., [UniProtKB, PubMed]; Endogenous ligand for GPR83. Neuropeptide involved in the regulation of feeding., [UniProtKB, PubMed]; Increased expression and retention of the secretory chaperone proSAAS following cell stress. Erratum:[Cell Stress Chaperones. 2020 Nov;25(6):943. doi: 10.1007/s12192-020-01138-5. PMID: 32691307], [RefSeq, PubMed]; May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 87 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity., [UniProtKB, PubMed, PubMed, PubMed]; Mice lacking proSAAS display alterations in emotion, consummatory behavior and circadian entrainment., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q91W26", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0009409 response to cold;GO:0016486 peptide hormone processing;GO:0002021 response to dietary excess", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9QXV0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WU78-1", "uniprot_id": [ { "id": "PDC6I_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WU78", "type": "external" } ], "mass": 96024.0, "length": 869, "protein_name": "Programmed cell death 6-interacting protein", "gene_name": "Pdcd6ip", "organism": "Mouse", "refseq_name": "programmed cell death 6-interacting protein isoform 1", "refseq_ac": [ { "id": "NP_001158149", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158149", "type": "external" } ], "gene_names_uniprotkb": "Pdcd6ip; Aip1; Alix", "gene_names_refseq": "Aip1; Alix; Eig2; Pdcd6ip; mKIAA1375", "protein_names_uniprotkb": "Programmed cell death 6-interacting protein; ALG-2-interacting protein 1; ALG-2-interacting protein X; E2F1-inducible protein; Eig2", "protein_names_refseq": "ALG-2-interacting protein 1; ALG-2-interacting protein X; Alg2-interacting protein 1; Alg2-interacting protein X; E2f1-inducible protein; programmed cell death 6-interacting protein isoform 1", "tax_id": 10090, "disease": "primary autosomal recessive microcephaly 29 (Disease Ontology:DOID:0051040)", "pathway": " (mmu:18571); (R-MMU-5213460); (R-MMU-5675482)", "pathway_count": 3, "publication_count": 30, "publication_id_list": "10.1101/2023.09.13.557529;10200558;10556317;11927596;12034747;20173027;22645316;22660413;23523921;25153642;25428506;25686249;26495903;26740625;27336173;28135057;28528544;29125738;30084848;30779550;31219806;31599954;33300544;34428180;37453647;37507081;39627609;39927985;40684658;9880530", "class_list": "", "function": "Biochemical characterization of two analogues of the apoptosis-linked gene 2 protein in Dictyostelium discoideum and interaction with murine Alix., [RefSeq, PubMed]; Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (By similarity). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (PubMed:27336173)., [UniProtKB, PubMed, UniProtKB]; Overexpression of Alix-CT leads to cytoplasmic vacuolization into tubulo-vesicular structures, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O88695;O89014;Q3TED2;Q8BSL8;Q8R0H5;Q99LR3;Q9QZN8", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0042803 protein homodimerization activity;GO:0046983 protein dimerization activity;GO:0048306 calcium-dependent protein binding;GO:0031871 proteinase activated receptor binding", "go_cellular_component": "GO:0005768 endosome;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005923 bicellular tight junction;GO:0043025 neuronal cell body", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:0039702 viral budding via host ESCRT complex;GO:0090559 regulation of membrane permeability;GO:0015031 protein transport;GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q9WU78-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2J6-1", "uniprot_id": [ { "id": "PD2R2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2J6", "type": "external" } ], "mass": 42950.0, "length": 382, "protein_name": "Prostaglandin D2 receptor 2", "gene_name": "Ptgdr2", "organism": "Mouse", "refseq_name": "prostaglandin D2 receptor 2", "refseq_ac": [ { "id": "NP_034092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034092", "type": "external" } ], "gene_names_uniprotkb": "Ptgdr2; Crth2; Gpr44", "gene_names_refseq": "Crth2; Gpr44; Grp45; Ptgdr2", "protein_names_uniprotkb": "Prostaglandin D2 receptor 2; Chemoattractant receptor-homologous molecule expressed on Th2 cells; G protein-coupled receptor 44", "protein_names_refseq": "G-protein coupled receptor 44; PGD2 receptor; chemoattractant receptor-homologous molecule expressed on TH2 cells; prostaglandin D2 receptor 2; prostaglandin D2 receptor CRTH2", "tax_id": 10090, "disease": "aspergillosis (Disease Ontology:DOID:13564); cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); rhinitis (Disease Ontology:DOID:4483); allergic asthma (Disease Ontology:DOID:9415); pulmonary eosinophilia (Disease Ontology:DOID:9498)", "pathway": " (mmu:14764); (R-MMU-391908); (R-MMU-418594)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12878180;15065763;15563582;16030019;16888024;21183079;35354317;39173086;9931443", "class_list": "", "function": "Analysis of prostaglandin D2 receptor CRTH2 determinants of ligand binding affinity and selectivity, [RefSeq, PubMed]; CRTH2 can be activated by indomethacin, a nonselective cyclooxygenase inhibitor and widely used nonsteroidal anti-inflammatory drug (NSAID)., [RefSeq, PubMed]; CRTH2 protein structure and expression (review) Review article, [RefSeq, PubMed]; DP1 (Prostaglandin D2 Receptor 1) Activation Protects Against Vascular Remodeling and Vascular Smooth Muscle Cell Transition to Myofibroblasts in Angiotensin II-Induced Hypertension in Mice. Erratum:[Hypertension. 2022 Aug;79(8):e127. doi: 10.1161/HYP.0000000000000218. PMID: 35861754], [RefSeq, PubMed]; Endogenous PGD2 acting on DP2 receptor counter regulates Schistosoma mansoni infection-driven hepatic granulomatous fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; Gene structure and functional properties of CRTH2, a prostaglandin D2 receptor., [RefSeq, PubMed]; Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q54A00", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004958 prostaglandin F receptor activity;GO:0001785 prostaglandin J receptor activity;GO:0004956 prostaglandin D receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:2000255 negative regulation of male germ cell proliferation;GO:0006935 chemotaxis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9Z2J6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97350-1", "uniprot_id": [ { "id": "PKP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97350", "type": "external" } ], "mass": 80896.0, "length": 728, "protein_name": "Plakophilin-1", "gene_name": "Pkp1", "organism": "Mouse", "refseq_name": "plakophilin-1", "refseq_ac": [ { "id": "NP_001300630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300630", "type": "external" } ], "gene_names_uniprotkb": "Pkp1", "gene_names_refseq": "Pkp1", "protein_names_uniprotkb": "Plakophilin-1", "protein_names_refseq": "plakophilin-1", "tax_id": 10090, "disease": "ectodermal dysplasia (Disease Ontology:DOID:2121)", "pathway": " (mmu:18772); (R-MMU-351906); (R-MMU-6798695); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10852826;18079750;21183079;21750661;27015268;27033150;27375112;28507225;29678907;30841437;30949721;34428180;36064721;36210013", "class_list": "", "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:27033150, PubMed:29678907). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:27033150, PubMed:29678907). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (By similarity). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (PubMed:28507225). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (PubMed:27375112). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (PubMed:30949721). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:27033150). Required for tight junction inside-out transepidermal barrier function of the skin, and is thereby involved in neonatal survival possibly via maintenance of hydration levels (PubMed:27033150). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (PubMed:27015268). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (By similarity). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (By similarity). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:27375112)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; PKP1 was identified as a new potential tumor suppressor in human melanoma., [RefSeq, PubMed]; Pkp1 regulates desmoglein membrane availability, whereas Pkp1 but not Pkp3 is required for desmoglein 3 clustering., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RSX3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0045296 cadherin binding;GO:0005521 lamin binding", "go_cellular_component": "GO:0097165 nuclear stress granule;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0045110 intermediate filament bundle assembly;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P97350-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR16-1", "uniprot_id": [ { "id": "PPID_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR16", "type": "external" } ], "mass": 40743.0, "length": 370, "protein_name": "Peptidyl-prolyl cis-trans isomerase D", "gene_name": "Ppid", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase D isoform 1", "refseq_ac": [ { "id": "NP_080628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080628", "type": "external" } ], "gene_names_uniprotkb": "Ppid", "gene_names_refseq": "4930564J03Rik; CYP-40; Ppidl; Ppid", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase D; 40 kDa peptidyl-prolyl cis-trans isomerase; 5.2.1.8; CYP-40; Cyclophilin-40; PPIase D; Rotamase D", "protein_names_refseq": "40 kDa peptidyl-prolyl cis-trans isomerase; PPIase D; cyclophilin-40; cytoplasmic cyclophilin D; peptidyl-prolyl cis-trans isomerase D isoform 1; peptidyl-prolyl cis-trans isomerase D; rotamase D", "tax_id": 10090, "disease": "", "pathway": " (mmu:67738); (R-MMU-8939211)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "18771283;21750661;23806337;24811325;31219806;31227743;34428180;9195923", "class_list": "", "function": "Involvement of Hsp90 and cyclophilins in intoxication by AIP56, a metalloprotease toxin from Photobacterium damselae subsp. piscicida. Erratum:[Sci Rep. 2020 Jan 22;10(1):1266. doi: 10.1038/s41598-020-58152-x. PMID: 31965037] Publication Status: Online-Only, [RefSeq, PubMed]; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity region. Involved in regulation of UV radiation-induced apoptosis., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543G1", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0031072 heat shock protein binding;GO:0008134 transcription factor binding;GO:0030331 nuclear estrogen receptor binding;GO:0051879 Hsp90 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0015031 protein transport;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0050714 positive regulation of protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CR16-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZL5-1", "uniprot_id": [ { "id": "PHS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZL5", "type": "external" } ], "mass": 14830.0, "length": 136, "protein_name": "Pterin-4-alpha-carbinolamine dehydratase 2", "gene_name": "Pcbd2", "organism": "Mouse", "refseq_name": "pterin-4-alpha-carbinolamine dehydratase 2", "refseq_ac": [ { "id": "NP_082557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082557", "type": "external" } ], "gene_names_uniprotkb": "Pcbd2; Dcoh2; Dcohm", "gene_names_refseq": "2700061N24Rik; Dcoh2; Dcohm; Pcbd2", "protein_names_uniprotkb": "Pterin-4-alpha-carbinolamine dehydratase 2; 4-alpha-hydroxy-tetrahydropterin dehydratase 2; 4.2.1.96; DcoH-like protein DCoHm; Dimerization cofactor of hepatocyte nuclear factor 1 from muscle; HNF-1-alpha dimerization cofactor; PHS 2", "protein_names_refseq": "4-alpha-hydroxy-tetrahydropterin dehydratase 2; HNF-1-alpha dimerization cofactor; PHS 2; dcoH-like protein DCoHm; dimerization cofactor of hepatocyte nuclear factor 1 (HNF1) from muscle; dimerization cofactor of hepatocyte nuclear factor 1 from muscle; pterin-4-alpha-carbinolamine dehydratase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72562)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15182178;16452087;21750661;23576753;23806337;24389307;37507081", "class_list": "", "function": "Deletion of intestinal SIRT1 impairs DCoH2-HNF-1alpha-FXR signaling and alters systemic bile acid homeostasis., [RefSeq, PubMed]; HNF1alpha binding kinetics may distinguish regulation by DCoH2, under thermodynamic control, from regulation by DCoH, under kinetic control, [RefSeq, PubMed]; Plays a role in tetrahydrobiopterin biosynthesis which is a co-factor for amino acid hydroxylases (PubMed:15182178). May prevent both the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (PubMed:24389307). Also acts as a coactivator for HNF1B-dependent transcription (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.96", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.96", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity;GO:0004505 phenylalanine 4-monooxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0006729 tetrahydrobiopterin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CZL5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BTI9-1", "uniprot_id": [ { "id": "PK3CB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BTI9", "type": "external" } ], "mass": 121711.0, "length": 1064, "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform", "gene_name": "Pik3cb", "organism": "Mouse", "refseq_name": "phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform", "refseq_ac": [ { "id": "NP_083370", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083370", "type": "external" } ], "gene_names_uniprotkb": "Pik3cb", "gene_names_refseq": "1110001J02Rik; Pik3cb; p110beta", "protein_names_uniprotkb": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; 2.7.1.153; 2.7.11.1; PI3-kinase subunit beta; PI3K-beta; PI3Kbeta; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; PtdIns-3-kinase subunit beta; PtdIns-3-kinase subunit p110-beta; Serine/threonine protein kinase PIK3CB; p110beta", "protein_names_refseq": "PI3-kinase subunit beta; PI3K-beta; PI3Kbeta; phosphatidylinositol 3-kinase, catalytic, beta polypeptide; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; ptdIns-3-kinase subunit beta; ptdIns-3-kinase subunit p110-beta; serine/threonine protein kinase PIK3CB", "tax_id": 10090, "disease": "thrombosis (Disease Ontology:DOID:0060903); prostate cancer (Disease Ontology:DOID:10283); heart disease (Disease Ontology:DOID:114); endometrial cancer (Disease Ontology:DOID:1380); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); rectal benign neoplasm (Disease Ontology:DOID:1984); prostate adenocarcinoma (Disease Ontology:DOID:2526); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); glucose metabolism disease (Disease Ontology:DOID:4194); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:74769); (R-MMU-109704); (R-MMU-112399); (R-MMU-114604); (R-MMU-1257604); (R-MMU-1660499); (R-MMU-186763); (R-MMU-198203); (R-MMU-201556); (R-MMU-202424); (R-MMU-2029485); (R-MMU-210993); (R-MMU-2424491); (R-MMU-2730905); (R-MMU-389357); (R-MMU-4420097); (R-MMU-512988); (R-MMU-5673001); (R-MMU-6811558); (R-MMU-8853659); (R-MMU-9027276); (R-MMU-912526); (R-MMU-912631); (R-MMU-9842663); (R-MMU-9927354)", "pathway_count": 25, "publication_count": 16, "publication_id_list": "11919689;12869549;12870650;18544649;18594509;19515725;19940148;20065293;21059846;21183079;21362552;21750661;30059200;31219806;34428180;37076617", "class_list": "", "function": "Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase, [RefSeq, PubMed]; P110beta is the major class I catalytic isoform required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by primary macrophages, [RefSeq, PubMed]; P85 and p110 subunits of PI3-kinase play a role in NF-kappaB activation through interaction with tyrosine-phosphorylated I(kappa)B-alpha and contribute to tyrosine phosphorylation of p65 NF-kappaB, [RefSeq, PubMed]; PI3Kbeta controls immune evasion in PTEN-deficient breast tumours., [RefSeq, PubMed]; Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G protein-coupled receptor (GPCR) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. Also has a protein kinase activity showing autophosphorylation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4Q1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" }, { "id": "2.7.1.151", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.151", "type": "external" }, { "id": "2.7.1.140", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.140", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0043560 insulin receptor substrate binding;GO:0016303 1-phosphatidylinositol-3-kinase activity;GO:0046934 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0003376 sphingosine-1-phosphate receptor signaling pathway;GO:0002931 response to ischemia;GO:0006897 endocytosis;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8BTI9-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UH93-1", "uniprot_id": [ { "id": "PLXD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UH93", "type": "external" } ], "mass": 211608.0, "length": 1925, "protein_name": "Plexin-D1", "gene_name": "Plxnd1", "organism": "Mouse", "refseq_name": "plexin-D1 precursor", "refseq_ac": [ { "id": "NP_080652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080652", "type": "external" } ], "gene_names_uniprotkb": "Plxnd1", "gene_names_refseq": "6230425C21Rik; Plxnd1; b2b1863Clo; b2b553Clo", "protein_names_uniprotkb": "Plexin-D1", "protein_names_refseq": "plexin-D1 precursor", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); DiGeorge syndrome (Disease Ontology:DOID:11198); transient cerebral ischemia (Disease Ontology:DOID:224); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:67784); (R-MMU-416700); (R-MMU-9696270)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;15239958;17318185;18992737;19027330;19421194;21750661;22179111;25428506;30899004;31599954;33300544;37828378", "class_list": "", "function": "Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Mediates anti-angiogenic signaling in response to SEMA3E. Required for normal development of the heart and vasculature., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Interruption of Plexin D1 pathway in mice results in congenital heart disease and vascular patterning defects due to endothelial defects., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 9, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 9, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 9, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 12, "disease_count": 4, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "Q68HV1", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0017154 semaphorin receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0030424 axon", "go_biological_process": "GO:0001525 angiogenesis;GO:0007162 negative regulation of cell adhesion;GO:0071526 semaphorin-plexin signaling pathway;GO:0001822 kidney development;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q3UH93-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZC2-1", "uniprot_id": [ { "id": "PLXC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZC2", "type": "external" } ], "mass": 176474.0, "length": 1574, "protein_name": "Plexin-C1", "gene_name": "Plxnc1", "organism": "Mouse", "refseq_name": "plexin-C1 precursor", "refseq_ac": [ { "id": "NP_061267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061267", "type": "external" } ], "gene_names_uniprotkb": "Plxnc1; Vespr", "gene_names_refseq": "2510048K12Rik; CD232; Plxnc1; Vespr", "protein_names_uniprotkb": "Plexin-C1; Virus-encoded semaphorin protein receptor", "protein_names_refseq": "plexin-C1 precursor; viral-encoded semaphorin protein receptor; virus-encoded semaphorin protein receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:54712); (R-MMU-416700)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;15611227;15967782;21183079;21750661;26495903;26740625;30084848;30899004;33300544;34428180;39169397;9806843", "class_list": "", "function": "Plexin C1 influences immune response to intracellular LPS and survival in murine sepsis. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for SEMA7A, for vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 16, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 16, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 16, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 23, "disease_count": 0, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "Q8CGW1", "ec_number_list": [], "go_molecular_function": "GO:0017154 semaphorin receptor activity", "go_cellular_component": "GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane;GO:0150053 cerebellar climbing fiber to Purkinje cell synapse", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0071526 semaphorin-plexin signaling pathway;GO:0007416 synapse assembly;GO:0030334 regulation of cell migration;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 5.4, "record_id": "Q9QZC2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35245-1", "uniprot_id": [ { "id": "PKD2_MOUSE", "url": "https://www.uniprot.org/uniprot/O35245", "type": "external" } ], "mass": 108982.0, "length": 966, "protein_name": "Polycystin-2", "gene_name": "Pkd2", "organism": "Mouse", "refseq_name": "polycystin-2", "refseq_ac": [ { "id": "NP_032887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032887", "type": "external" } ], "gene_names_uniprotkb": "Pkd2; TRPP2", "gene_names_refseq": "C030034P18Rik; PC2; Pkd2; TRPP2", "protein_names_uniprotkb": "Polycystin-2; Polycystic kidney disease 2 protein homolog; Transient receptor potential cation channel subfamily P member 2", "protein_names_refseq": "polycystic kidney disease 2 protein homolog; polycystin-2; transient receptor potential cation channel subfamily P member 2", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340); polycystic kidney disease (Disease Ontology:DOID:0080322); polycystic kidney disease 2 (Disease Ontology:DOID:0110859); intracranial aneurysm (Disease Ontology:DOID:10941); acute kidney failure (Disease Ontology:DOID:3021); retinal degeneration (Disease Ontology:DOID:8466); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (mmu:18764); (R-MMU-5620916)", "pathway_count": 2, "publication_count": 43, "publication_id_list": "10.1101/2023.09.13.557529;10615132;10760273;10770959;10873385;10913159;11854751;12062060;12514735;12640140;15692563;16192288;16551655;17404231;18235101;18695040;20096584;21183079;21307093;21670265;22983710;23858011;24129315;25405894;25798941;27214281;27760766;29443690;30084848;30511640;31048699;31219806;31822608;34203471;34428180;35820727;35835458;36210013;36603091;38782303;9339380;9568711;9716661", "class_list": "glycogene", "function": "Forms a nonselective cation channel. Can function as a homotetrameric ion channel or can form heteromer with PKD1 (PubMed:12640140, PubMed:25405894, PubMed:27214281, PubMed:27760766, PubMed:29443690). Displays distinct function depending on its subcellular localization and regulation by its binding partners. Functions as a cation channel, with a preference for monovalent cations over divalent cations that allows K(+), Na(+) and Ca(2+) influx, with low selectivity for Ca(2+). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:12514735, PubMed:12640140, PubMed:18695040, PubMed:27760766, PubMed:29443690, PubMed:31048699). In the endoplasmic reticulum, likely functions as a K(+) channel to facilitate Ca(2+) release (PubMed:35835458). The heterotetrameric PKD1/PKD2 channel has higher Ca(2+) permeability than homomeric PKD2 channel and acts as a primarily Ca(2+)-permeable channel (By similarity). PKD1 and PKD2 may function through a common signaling pathway that is necessary to maintain the normal, differentiated state of renal tubule cells (PubMed:10615132, PubMed:9568711). Interacts with and acts as a regulator of a number of other channels, such as TRPV4, TRPC1, IP3R, RYR2, ultimately further affecting intracellular signaling, to modulate intracellular Ca(2+) signaling. Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). In cardiomyocytes, PKD2 modulates Ca(2+) release from stimulated RYR2 receptors through direct association (PubMed:17404231). Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning (PubMed:21307093, PubMed:22983710). Acts as a regulator of cilium length together with PKD1 (PubMed:20096584). Mediates systemic blood pressure and contributes to the myogenic response in cerebral arteries though vasoconstriction (PubMed:23858011, PubMed:30511640, PubMed:31822608)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; PKD2 regulates autophagy and forms a protein complex with BECN1 at the primary cilium of hypothalamic neuronal cells., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 40, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "C0KJK2;E9Q4F6;E9QQA3;Q8BPR6;Q9ES37;Q9QWP0;Q9Z193;Q9Z194", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0015271 outward rectifier potassium channel activity;GO:0005102 signaling receptor binding;GO:0005262 calcium channel activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0045180 basal cortex;GO:0034703 cation channel complex;GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0002133 polycystin complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0090279 regulation of calcium ion import;GO:0003127 detection of nodal flow;GO:0072208 metanephric smooth muscle tissue development;GO:0072218 metanephric ascending thin limb development;GO:0001889 liver development", "synthesized_glycan_count": 0, "hit_score": 4.8, "record_id": "O35245-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000010001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70343-1", "uniprot_id": [ { "id": "PRGC1_MOUSE", "url": "https://www.uniprot.org/uniprot/O70343", "type": "external" } ], "mass": 90588.0, "length": 797, "protein_name": "Peroxisome proliferator-activated receptor gamma coactivator 1-alpha", "gene_name": "Ppargc1a", "organism": "Mouse", "refseq_name": "peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform a", "refseq_ac": [ { "id": "NP_032930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032930", "type": "external" } ], "gene_names_uniprotkb": "Ppargc1a; Pgc1a; Pgc1; Ppargc1", "gene_names_refseq": "A830037N07Rik; Gm11133; PGC-1; PPARGC-1-alpha; Pgc-1alpha; Pgc1; Pgco1; Ppargc1a; Ppargc1", "protein_names_uniprotkb": "Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha", "protein_names_refseq": "PPAR-gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); cardiomyopathy (Disease Ontology:DOID:0050700); renal fibrosis (Disease Ontology:DOID:0050855); colitis (Disease Ontology:DOID:0060180); abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); amblyopia (Disease Ontology:DOID:10376); Alzheimer's disease (Disease Ontology:DOID:10652); kidney failure (Disease Ontology:DOID:1074); age related macular degeneration (Disease Ontology:DOID:10871); amnestic disorder (Disease Ontology:DOID:10914); heart disease (Disease Ontology:DOID:114); sciatic neuropathy (Disease Ontology:DOID:11446); prediabetes syndrome (Disease Ontology:DOID:11716); nephrotic syndrome (Disease Ontology:DOID:1184); morbid obesity (Disease Ontology:DOID:11981); primary biliary cholangitis (Disease Ontology:DOID:12236); Huntington's disease (Disease Ontology:DOID:12858); cardiovascular system disease (Disease Ontology:DOID:1287); dilated cardiomyopathy (Disease Ontology:DOID:12930); Parkinson's disease (Disease Ontology:DOID:14330); malignant fibrous histiocytoma (Disease Ontology:DOID:1907); melanoma (Disease Ontology:DOID:1909); kidney cancer (Disease Ontology:DOID:263); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); placental insufficiency (Disease Ontology:DOID:3891); hyperglycemia (Disease Ontology:DOID:4195); macular degeneration (Disease Ontology:DOID:4448); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hyperthyroidism (Disease Ontology:DOID:7998); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:19017)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "11108270;12754525;14744933;15716268;15744310;16950137;17476214;17554339;17609368;17618855;18483224;20074525;21750661;22237023;22883232;22886304;23217713;25428506;26993634;30084848;34167027;34428180;35820727;9529258", "class_list": "", "function": "This gene encodes a transcriptional coactivator that induces and coordinates gene expression regulating mitochondrial biogenesis, respiration, hepatic gluconeogenesis, thermogenic program in brown fat and muscle fiber-type switching. Mice lacking the encoded protein exhibit reduced thermogenic capacity, hyperactivity and resistance to diet-induced obesity. Mice lacking the encoded protein specifically in the heart exhibit peripartum cardiomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]., [RefSeq]; Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:12754525, PubMed:15744310, PubMed:23217713, PubMed:9529258). Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter (PubMed:12754525, PubMed:15744310, PubMed:23217713, PubMed:9529258). Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis (PubMed:12754525, PubMed:15744310, PubMed:23217713, PubMed:9529258). Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism (PubMed:12754525, PubMed:15744310, PubMed:23217713, PubMed:9529258). Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (PubMed:12754525). Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner (By similarity). Also involved in the integration of the circadian rhythms and energy metabolism (PubMed:17476214). Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (PubMed:17476214)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 37, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "L0AM20;L0AN96;L0APB0;Q3UP72", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0031625 ubiquitin protein ligase binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0016605 PML body", "go_biological_process": "GO:2000272 negative regulation of signaling receptor activity;GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060612 adipose tissue development", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "O70343-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70477-1", "uniprot_id": [ { "id": "PKNX1_MOUSE", "url": "https://www.uniprot.org/uniprot/O70477", "type": "external" } ], "mass": 47539.0, "length": 436, "protein_name": "Homeobox protein PKNOX1", "gene_name": "Pknox1", "organism": "Mouse", "refseq_name": "homeobox protein PKNOX1 isoform 1", "refseq_ac": [ { "id": "NP_057879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057879", "type": "external" } ], "gene_names_uniprotkb": "Pknox1; Prep1", "gene_names_refseq": "D17Wsu76e; PREP1; Pknox1", "protein_names_uniprotkb": "Homeobox protein PKNOX1; PBX/knotted homeobox 1", "protein_names_refseq": "PBX/knotted homeobox 1; homeobox protein PKNOX1 isoform 1; homeobox protein PKNOX1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18771)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12529389;21183079;21750661;29465778;30337366;30604852;31618597;34428180;34679197", "class_list": "", "function": "(Microbial infection) In complex with PBX1, binds to the 5'-TGATTGAC-3' consensus sequence in the U5 region of Moloney murine leukemia virus and promotes viral transcription., [UniProtKB, PubMed]; A mechanism by which the DNA binding-independent activity of Sp2 potentiates genomic loading of Pbx1:Prep1 and Nf-y to composite motifs present in many promoters of highly expressed genes, [RefSeq, PubMed]; Activates transcription in the presence of PBX1A and HOXA1., [UniProtKB, PubMed]; Interleukin 6 reduces vascular smooth muscle cell apoptosis via Prep1 and is associated with aging., [RefSeq, PubMed]; Prep1, complexing with p160, decreases PGC-1alpha and stimulates angiogenesis., [RefSeq, PubMed]; We conclude that Prep1 is required for normal adult mammary gland development, in particular at its branching morphogenesis step. By binding Snail2, Prep1 protects it from the proteasomal degradation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TT01", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030218 erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O70477-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20108-1", "uniprot_id": [ { "id": "PRDX3_MOUSE", "url": "https://www.uniprot.org/uniprot/P20108", "type": "external" } ], "mass": 28127.0, "length": 257, "protein_name": "Thioredoxin-dependent peroxide reductase, mitochondrial", "gene_name": "Prdx3", "organism": "Mouse", "refseq_name": "thioredoxin-dependent peroxide reductase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_031478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031478", "type": "external" } ], "gene_names_uniprotkb": "Prdx3; Aop1; Mer5", "gene_names_refseq": "Aop1; D0Tohi1; Ef2l; Mer5; Prdx3; Prx3; SP22; TDXM", "protein_names_uniprotkb": "Thioredoxin-dependent peroxide reductase, mitochondrial; 1.11.1.24; AOP-1; Antioxidant protein 1; PRX III; Perioredoxin-3; Protein MER5; Thioredoxin-dependent peroxiredoxin 3", "protein_names_refseq": "AOP-1; Prx III; anti-oxidant protein 1; mitochondrial Trx dependent peroxide reductase; mitochondrial thioredoxin dependent peroxide reductase; perioredoxin-3; peroxiredoxin III; thioredoxin-dependent peroxide reductase, mitochondrial precursor; thioredoxin-dependent peroxide reductase, mitochondrial; thioredoxin-dependent peroxiredoxin 3", "tax_id": 10090, "disease": "autosomal recessive spinocerebellar ataxia 32 (Disease Ontology:DOID:0070413); glucose intolerance (Disease Ontology:DOID:10603)", "pathway": " (mmu:11757); (R-MMU-3299685)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "23576753;23806337;2583515;27037278;28135057;30084848;31616917;31740833;36288343;37453647;37507081;38431661;38945958;9497357", "class_list": "", "function": "Peroxiredoxin 3 has a crucial role in the macrophage polarization by regulating mitochondrial homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (By similarity). Required for the maintenance of physical strength (PubMed:27037278)., [UniProtKB, UniProtKB, PubMed]; YAP1 inhibits the senescence of alveolar epithelial cells by targeting Prdx3 to alleviate pulmonary fibrosis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0008379 thioredoxin peroxidase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0008284 positive regulation of cell population proliferation;GO:0032496 response to lipopolysaccharide;GO:0043066 negative regulation of apoptotic process;GO:0051881 regulation of mitochondrial membrane potential", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P20108-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FH0-1", "uniprot_id": [ { "id": "PKP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q68FH0", "type": "external" } ], "mass": 131551.0, "length": 1190, "protein_name": "Plakophilin-4", "gene_name": "Pkp4", "organism": "Mouse", "refseq_name": "plakophilin-4 isoform 1", "refseq_ac": [ { "id": "NP_080637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080637", "type": "external" } ], "gene_names_uniprotkb": "Pkp4; Armrp", "gene_names_refseq": "5031422I09Rik; 9430019K17Rik; Armrp; Pkp4; p0071", "protein_names_uniprotkb": "Plakophilin-4; Armadillo-related protein", "protein_names_refseq": "armadillo-related protein; plakophilin-4 isoform 1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:227937); (R-MMU-6805567); (R-MMU-6809371); (R-MMU-9696264); (R-MMU-9696270); (R-MMU-9696273)", "pathway_count": 6, "publication_count": 22, "publication_id_list": "16452087;17114649;18034455;21183079;21750661;22517741;22645316;22826440;24129315;25428506;28657654;30084848;31219806;32848054;33300544;34428180;34678516;34887587;35822049;36852467;40021952;40885482", "class_list": "", "function": "Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 20, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 20, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 20, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 34, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "A2AS46;Q640N0;Q68G56;Q8BK47;Q8BVH1;Q9CRE3", "ec_number_list": [], "go_molecular_function": "GO:0045296 cadherin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0035023 regulation of Rho protein signal transduction;GO:0007043 cell-cell junction assembly;GO:0032467 positive regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "Q68FH0-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6KAU7-1", "uniprot_id": [ { "id": "PKHG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6KAU7", "type": "external" } ], "mass": 143376.0, "length": 1340, "protein_name": "Pleckstrin homology domain-containing family G member 2", "gene_name": "Plekhg2", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family G member 2 isoform b", "refseq_ac": [ { "id": "NP_001077381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077381", "type": "external" } ], "gene_names_uniprotkb": "Plekhg2", "gene_names_refseq": "Clg; Cslg; Plekhg2", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family G member 2; Common site lymphoma/leukemia GEF; Common site lymphoma/leukemia guanine nucleotide exchange factor; PH domain-containing family G member 2", "protein_names_refseq": "PH domain-containing family G member 2; common site lymphoma/leukemia guanine nucleotide exchange factor; common-site lymphoma/leukemia GEF; pleckstrin homology domain-containing family G member 2 isoform b; pleckstrin homology domain-containing family G member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:101497); (R-MMU-193648); (R-MMU-416482); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "11839748;21750661;25428506;30059200;31219806;32782141;33492483;36852467", "class_list": "", "function": "Expression analyses of PLEKHG2, a Rho family-specific guanine nucleotide exchange factor, during mouse brain development., [RefSeq, PubMed]; May be a transforming oncogene with exchange activity for CDC42. May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42 (PubMed:11839748). Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (By similarity). Involved in the regulation of actin polymerization (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0PJD9;Q3UNL4;Q6PGK2;Q7TS89;Q8R4H6", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6KAU7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TQ5-1", "uniprot_id": [ { "id": "PKHM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TQ5", "type": "external" } ], "mass": 112734.0, "length": 1018, "protein_name": "Pleckstrin homology domain-containing family M member 2", "gene_name": "Plekhm2", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family M member 2 isoform 1", "refseq_ac": [ { "id": "NP_001028322", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028322", "type": "external" } ], "gene_names_uniprotkb": "Plekhm2; Kiaa0842", "gene_names_refseq": "2310034J19Rik; Plekhm2; mKIAA0842", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family M member 2; PH domain-containing family M member 2", "protein_names_refseq": "PH domain-containing family M member 2; pleckstrin homology domain-containing family M member 2 isoform 1; pleckstrin homology domain-containing family M member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:69582)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19801640;21183079;21750661;26268777;34428180;38942823", "class_list": "", "function": "Data shoe that the N-terminal domain of SifA is sufficient to interact with the pleckstrin homology domain of SKIP, forming a 1:1 complex with a micromolar dissociation constant., [RefSeq, PubMed]; Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility. Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plekhm2 acts as an autophagy modulator in murine heart and cardiofibroblasts. Publication Status: Online-Only, [RefSeq, PubMed]; We used a model of SKIP knockout mice to show that this protein mediates the host susceptibility to salmonellosis and to establish that SifA also contributes to Salmonella virulence independently of its interaction with SKIP Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ADE1;Q3U0Q7;Q6PD22", "ec_number_list": [], "go_molecular_function": "GO:0019894 kinesin binding", "go_cellular_component": "GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0010008 endosome membrane;GO:0044754 autolysosome", "go_biological_process": "GO:0032880 regulation of protein localization;GO:0007030 Golgi organization;GO:0032418 lysosome localization;GO:1902774 late endosome to lysosome transport;GO:0042267 natural killer cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80TQ5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BFZ2-1", "uniprot_id": [ { "id": "PLPR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BFZ2", "type": "external" } ], "mass": 35932.0, "length": 325, "protein_name": "Phospholipid phosphatase-related protein type 1", "gene_name": "Plppr1", "organism": "Mouse", "refseq_name": "phospholipid phosphatase-related protein type 1", "refseq_ac": [ { "id": "NP_848871", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848871", "type": "external" } ], "gene_names_uniprotkb": "Plppr1; Kiaa4247; Lppr1; Prg3", "gene_names_refseq": "E130309F12Rik; Lppr1; PRG-3; Plppr1; mKIAA4247", "protein_names_uniprotkb": "Phospholipid phosphatase-related protein type 1; Inactive 2-lysophosphatidate phosphatase PLPPR1; Lipid phosphate phosphatase-related protein type 1; PRG-3; Plasticity-related gene 3 protein", "protein_names_refseq": "inactive 2-lysophosphatidate phosphatase PLPPR1; lipid phosphate phosphatase-related protein type 1; phospholipid phosphatase-related protein type 1; plasticity-related gene 3 protein; plasticity-related protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:272031); (R-MMU-419408)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "14750979;15345747;16144631;21183079;32061832;33320336", "class_list": "", "function": "May play a role in neurite outgrowth and neurogenesis., [UniProtKB, UniProtKB]; Phospholipid phosphatase related 1 (PLPPR1) increases cell adhesion through modulation of Rac1 activity., [RefSeq, PubMed]; The lipid phosphatase-like protein PLPPR1 associates with RhoGDI1 to modulate RhoA activation in response to axon growth inhibitory molecules., [RefSeq, PubMed]; This study demonstrated that plasticity-related gene-3 (PRG-3) is differentially expressed between the dorsal and lateral cortex at P6., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q4V9R3;Q5DTF2;Q8BID2;Q8BIQ1", "ec_number_list": [], "go_molecular_function": "GO:0008195 phosphatidate phosphatase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0006644 phospholipid metabolic process;GO:0046839 phospholipid dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BFZ2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K124-1", "uniprot_id": [ { "id": "PKHO2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K124", "type": "external" } ], "mass": 53872.0, "length": 495, "protein_name": "Pleckstrin homology domain-containing family O member 2", "gene_name": "Plekho2", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family O member 2", "refseq_ac": [ { "id": "NP_694759", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694759", "type": "external" } ], "gene_names_uniprotkb": "Plekho2; Plekhq1", "gene_names_refseq": "Plekho2; Plekhq1", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family O member 2; PH domain-containing family O member 2; PH domain-containing family Q member 1; Pleckstrin homology domain-containing family Q member 1", "protein_names_refseq": "PH domain-containing family O member 2; PH domain-containing family Q member 1; PH domain-containing protein homolog; pleckstrin homology domain containing, family Q member 1; pleckstrin homology domain-containing family O member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:102595); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19131326;19144319;21183079;25153642;28627369;34272357;35820727", "class_list": "", "function": "PLEKHO2 inhibits TNFalpha-induced cell death by suppressing RIPK1 activation. Publication Status: Online-Only, [RefSeq, PubMed]; PLEKHO2-deficient bone marrow-derived macrophages displayed increased apoptotic cell death in the absence of Macrophage-colony stimulating factor, although PLEKHO2 deficiency did not affect macrophage differentiation and proliferation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCY2;Q3U4R2;Q8C1F2;Q8R140", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0071888 macrophage apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8K124-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1R3-1", "uniprot_id": [ { "id": "PNPT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1R3", "type": "external" } ], "mass": 85683.0, "length": 783, "protein_name": "Polyribonucleotide nucleotidyltransferase 1, mitochondrial", "gene_name": "Pnpt1", "organism": "Mouse", "refseq_name": "polyribonucleotide nucleotidyltransferase 1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_082145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082145", "type": "external" } ], "gene_names_uniprotkb": "Pnpt1; Pnpase", "gene_names_refseq": "1200003F12Rik; Old35; PNPase; Pnpt1; Pnptl1", "protein_names_uniprotkb": "Polyribonucleotide nucleotidyltransferase 1, mitochondrial; 2.7.7.8; 3'-5' RNA exonuclease OLD35; PNPase 1; PNPase old-35; Polynucleotide phosphorylase 1; Polynucleotide phosphorylase-like protein", "protein_names_refseq": "3'-5' RNA exonuclease OLD35; PNPase 1; PNPase old-35; polynucleotide phosphorylase 1; polynucleotide phosphorylase-like protein; polyribonucleotide nucleotidyltransferase 1, mitochondrial precursor; polyribonucleotide nucleotidyltransferase 1, mitochondrial", "tax_id": 10090, "disease": "spinocerebellar ataxia 25 (Disease Ontology:DOID:0050974); autosomal recessive nonsyndromic deafness 70 (Disease Ontology:DOID:0110521); combined oxidative phosphorylation deficiency 13 (Disease Ontology:DOID:0111467)", "pathway": " (mmu:71701)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12419256;16966381;20691904;23576753;23806337;24788674;31219806;34203471;36596874", "class_list": "", "function": "Pnpt1 mediates NLRP3 inflammasome activation by MAVS and metabolic reprogramming in macrophages., [RefSeq, PubMed]; RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (By similarity). Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially. Also plays a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA., [UniProtKB, UniProtKB, PubMed]; The data support an unanticipated role for PNPASE in mediating the translocation of RNAs into mitochondria, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UEP9;Q810U7;Q812B3;Q8R2U3;Q9DC52", "ec_number_list": [ { "id": "2.7.7.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.8", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0035198 miRNA binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004654 polyribonucleotide nucleotidyltransferase activity;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0043457 regulation of cellular respiration;GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process;GO:0000964 mitochondrial RNA 5'-end processing;GO:0006397 mRNA processing;GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8K1R3-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K394-1", "uniprot_id": [ { "id": "PLCL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K394", "type": "external" } ], "mass": 125772.0, "length": 1128, "protein_name": "Inactive phospholipase C-like protein 2", "gene_name": "Plcl2", "organism": "Mouse", "refseq_name": "inactive phospholipase C-like protein 2", "refseq_ac": [ { "id": "NP_038908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038908", "type": "external" } ], "gene_names_uniprotkb": "Plcl2; Kiaa1092; Plce2", "gene_names_refseq": "PLC-L2; PRIP-2; Plce2; Plcl2; mKIAA1092", "protein_names_uniprotkb": "Inactive phospholipase C-like protein 2; PLC-L(2); PLC-L2; PLC-epsilon-2; Phospholipase C-L2; Phospholipase C-epsilon-2", "protein_names_refseq": "PLC-L(2); PLC-epsilon-2; inactive phospholipase C-like protein 2; phospholipase C, epsilon 2; phospholipase C-L2", "tax_id": 10090, "disease": "", "pathway": " (mmu:224860)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;10581172;14517301;15345747;17242355;20484733;21183079;25428506;26495903;28360101;30084848;30779550;30899004;31589911;34428180;36210013;39627609", "class_list": "", "function": "May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum., [UniProtKB, PubMed]; PLC-L2 is a novel negative regulator of BCR signaling and immune responses, [RefSeq, PubMed]; Phospholipase C-related catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic inflammation-mediated anorexia in mice., [RefSeq, PubMed]; These results suggest that PRIPs are positively involved in the development of follicles via their regulation of LH-LHR signaling and estradiol secretion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4E2;Q80TK5;Q9QYG1", "ec_number_list": [], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0050811 GABA receptor binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0002322 B cell proliferation involved in immune response;GO:0051209 release of sequestered calcium ion into cytosol;GO:0048015 phosphatidylinositol-mediated signaling;GO:0046488 phosphatidylinositol metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q8K394-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QY23-1", "uniprot_id": [ { "id": "PKP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QY23", "type": "external" } ], "mass": 87333.0, "length": 797, "protein_name": "Plakophilin-3", "gene_name": "Pkp3", "organism": "Mouse", "refseq_name": "plakophilin-3 isoform 2", "refseq_ac": [ { "id": "NP_001156396", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156396", "type": "external" } ], "gene_names_uniprotkb": "Pkp3", "gene_names_refseq": "2310056L12Rik; Pkp3", "protein_names_uniprotkb": "Plakophilin-3", "protein_names_refseq": "plakophilin-3 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:56460); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10381383;17242355;18079750;21183079;21750661;24129315;26173741;27033150;27375112;29678907;30949721;34428180;36689330;38395410", "class_list": "", "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (By similarity) (PubMed:18079750, PubMed:29678907). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (PubMed:30949721). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (By similarity). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (By similarity). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:18079750). May also regulate the protein abundance of the desmosome component PKP1 (PubMed:18079750). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (PubMed:18079750, PubMed:29678907). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (PubMed:27375112). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (PubMed:26173741). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (PubMed:26173741). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (PubMed:18079750). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (PubMed:36689330). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (PubMed:36689330). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (PubMed:36689330). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4QPD8;Q0VGP3;Q3KQL7", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0019899 enzyme binding;GO:0045296 cadherin binding;GO:0050839 cell adhesion molecule binding;GO:0045294 alpha-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0002718 regulation of cytokine production involved in immune response;GO:0045785 positive regulation of cell adhesion;GO:0072659 protein localization to plasma membrane;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9QY23-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWY3-1", "uniprot_id": [ { "id": "SETD6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWY3", "type": "external" } ], "mass": 52960.0, "length": 473, "protein_name": "N-lysine methyltransferase SETD6", "gene_name": "Setd6", "organism": "Mouse", "refseq_name": "N-lysine methyltransferase SETD6 isoform 1", "refseq_ac": [ { "id": "NP_001030295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030295", "type": "external" } ], "gene_names_uniprotkb": "Setd6", "gene_names_refseq": "0610039J04Rik; 3110004G14Rik; Setd6", "protein_names_uniprotkb": "N-lysine methyltransferase SETD6; 2.1.1.-; SET domain-containing protein 6", "protein_names_refseq": "N-lysine methyltransferase SETD6 isoform 1; N-lysine methyltransferase SETD6; SET domain-containing protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:66083); (R-MMU-3214841)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17242355;21183079;21750661;23324626", "class_list": "", "function": "Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (PubMed:23324626). Methylates PAK4., [UniProtKB, PubMed, UniProtKB]; SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RTA7;Q8C6I1", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" } ], "go_molecular_function": "GO:0051059 NF-kappaB binding;GO:0016279 protein-lysine N-methyltransferase activity;GO:1904047 S-adenosyl-L-methionine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0048863 stem cell differentiation;GO:0050727 regulation of inflammatory response;GO:0019827 stem cell population maintenance;GO:0018026 peptidyl-lysine monomethylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CWY3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88838-1", "uniprot_id": [ { "id": "SPSB2_MOUSE", "url": "https://www.uniprot.org/uniprot/O88838", "type": "external" } ], "mass": 28938.0, "length": 264, "protein_name": "SPRY domain-containing SOCS box protein 2", "gene_name": "Spsb2", "organism": "Mouse", "refseq_name": "SPRY domain-containing SOCS box protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001292979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292979", "type": "external" } ], "gene_names_uniprotkb": "Spsb2; Grcc9; Ssb2", "gene_names_refseq": "C9; Grcc9; SSB2; Spsb2", "protein_names_uniprotkb": "SPRY domain-containing SOCS box protein 2; Gene-rich cluster protein C9; SSB-2", "protein_names_refseq": "SPRY domain-containing SOCS box protein 2 isoform 1; SPRY domain-containing SOCS box protein 2; gene-rich cluster protein C9", "tax_id": 10090, "disease": "", "pathway": " (mmu:14794); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "15964819;16369487;17088318;20561531;20603330;21750661;28270450;31085591;31219806;33862200;9445485", "class_list": "", "function": "Backbone dynamics of SSB-2 by means of Modelfree analysis., [RefSeq, PubMed]; Collectively, Ssb1 and Ssb2 control crucial aspects of Hematopoietic stem and progenitor cells function, including proliferation and survival in vivo by resolving replicative stress to maintain genomic stability., [RefSeq, PubMed]; Determined the first SPRY-domain structure of SSB-2 that adopts a novel fold and contains conserved structural determinants for binding to prostate apoptosis response protein-4 (PAR-4)., [RefSeq, PubMed]; Genetic deletion of SOCS Box Protein 2 results in a very mild thrombocytopenia., [RefSeq, PubMed]; Structural basis for the regulation of inducible nitric oxide synthase by the SPRY domain-containing SOCS box protein SPSB2, an E3 ubiquitin ligase., [RefSeq, PubMed]; Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:20603330). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:20603330). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity)., [UniProtKB, UniProtKB, PubMed]; These results establish SSB1/2 as safeguards of B cell development and unveil their differential requirement in immature and mature B lymphocytes, [RefSeq, PubMed]; This gene encodes a member of the SSB family of proteins that contain a central SPRY (repeats in splA and ryanodine receptors) domain and a C-terminal SOCS (suppressor of cytokine signaling) box. The encoded protein is an adaptor protein in the E3 ubiquitin ligase complex that ubiquitinates inducible nitric oxide synthase and targets it for proteasomal degradation. Mice lacking the encoded protein exhibit lower blood urea nitrogen levels and mild thrombocytopenia due to reduced platelet production. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CBA5;Q91Z15", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0019005 SCF ubiquitin ligase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O88838-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q71LX4-1", "uniprot_id": [ { "id": "TLN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q71LX4", "type": "external" } ], "mass": 253621.0, "length": 2375, "protein_name": "Talin-2", "gene_name": "Tln2", "organism": "Mouse", "refseq_name": "talin-2 isoform 1", "refseq_ac": [ { "id": "NP_001074711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074711", "type": "external" } ], "gene_names_uniprotkb": "Tln2", "gene_names_refseq": "5730421P04Rik; Tln2; mKIAA0320", "protein_names_uniprotkb": "Talin-2", "protein_names_refseq": "talin-2 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70549)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;17242355;18034455;18299400;21183079;21750661;21952136;26495903;26740625;30084848;30899004;33300544;34428180;35333120;35984892;36210013;37507081;39215026;39927985", "class_list": "", "function": "As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity)., [UniProtKB]; Loss of talin in cardiac fibroblasts results in augmented ventricular cardiomyocyte hypertrophy in response to pressure overload., [RefSeq, PubMed]; Talin2 binds to non-muscle myosin IIa and regulates cell attachment and fibronectin secretion. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9QM49;Q8BWK0", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0005200 structural constituent of cytoskeleton;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0098609 cell-cell adhesion;GO:0099140 presynaptic actin cytoskeleton organization;GO:0007155 cell adhesion;GO:0034329 cell junction assembly", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q71LX4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MQ3-1", "uniprot_id": [ { "id": "PINK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MQ3", "type": "external" } ], "mass": 63181.0, "length": 580, "protein_name": "Serine/threonine-protein kinase PINK1, mitochondrial", "gene_name": "Pink1", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase PINK1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_081156", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081156", "type": "external" } ], "gene_names_uniprotkb": "Pink1", "gene_names_refseq": "1190006F07Rik; BRPK; Pink1; mFLJ00387", "protein_names_uniprotkb": "Serine/threonine-protein kinase PINK1, mitochondrial; 2.7.11.1; BRPK; PTEN-induced putative kinase protein 1", "protein_names_refseq": "PTEN-induced putative kinase protein 1; serine/threonine-protein kinase PINK1, mitochondrial precursor; serine/threonine-protein kinase PINK1, mitochondrial", "tax_id": 10090, "disease": "Parkinson's disease 6 (Disease Ontology:DOID:0060369); early-onset Parkinson's disease (Disease Ontology:DOID:0060894); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); Parkinsonism (Disease Ontology:DOID:0080855); Hirschsprung's disease (Disease Ontology:DOID:10487); Parkinson's disease (Disease Ontology:DOID:14330); testicular cancer (Disease Ontology:DOID:2998)", "pathway": " (mmu:68943); (R-MMU-5205685)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;11494141;14607334;14697668;16771836;17389931;18687901;19229105;20049710;21750661;24652937;24784582;25474007;29123128;31536960;32484300;34428180;35145192;41037851", "class_list": "", "function": "A lack of PINK1 gene function is insufficient to cause dopaminergic neuron death in mice. Publication Status: Online-Only, [RefSeq, PubMed]; PINK1 mRNA abundance is rather uniform throughout the different brain regions with expression in cortex, striatum, thalamus, brainstem and cerebellum., [RefSeq, PubMed]; PTEN +/- and PTEN +/+ mice weres compared in subventricular zone (SVZ) precursor cells. Using DNA microarrays, the expression profiles of PTEN +/+ and PTEN +/- cells and identified 91 differentially expressed genes in PTEN +/- precursor cells., [RefSeq, PubMed]; Serine/threonine-protein kinase which acts as a sensor of mitochondrial damage and protects against mitochondrial dysfunction during cellular stress (PubMed:24652937, PubMed:24784582, PubMed:25474007, PubMed:32484300). It phosphorylates mitochondrial proteins to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:24652937, PubMed:24784582, PubMed:25474007, PubMed:32484300). In healthy mitochondria, PINK1 is translocated across the mitochondrial outer membrane (MOM) via the translocase of the outer membrane (TOM) complex, and inserted into the mitochondrial inner membrane (MIM) via the translocase of the inner membrane (TIM23) complex where it is cleaved and released into the cytosol (By similarity). Depending on the severity of mitochondrial damage, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to eliminating severely damaged mitochondria via PINK1-PRKN-dependent mitophagy (By similarity). When cellular stress results in irreversible mitochondrial damage, PINK1 accumulates at the outer mitochondrial membrane (OMM) where it phosphorylates pre-existing polyubiquitin chains at 'Ser-65', recruits PRKN from the cytosol to the OMM and activates PRKN by phosphorylation at 'Ser-65' (PubMed:24652937, PubMed:24784582, PubMed:25474007, PubMed:32484300). Activated PRKN then ubiquitinates VDAC1 and other OMM proteins to initiate mitophagy (By similarity). The PINK1-PRKN pathway also promotes fission of damaged mitochondria by phosphorylating and thus promoting the PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (By similarity). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (By similarity). Also promotes mitochondrial fission independently of PRKN and ATG7-mediated mitophagy, via the phosphorylation and activation of DNM1L (PubMed:32484300). Regulates motility of damaged mitochondria by promoting the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (By similarity). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (PubMed:24652937). Phosphorylates LETM1, positively regulating its mitochondrial calcium transport activity (PubMed:29123128)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AM77;Q7TMZ3;Q811I8;Q91XU5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0055131 C3HC4-type RING finger domain binding;GO:0000287 magnesium ion binding;GO:0002020 protease binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:1901525 negative regulation of mitophagy;GO:1902902 negative regulation of autophagosome assembly;GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide;GO:0001934 positive regulation of protein phosphorylation;GO:0002931 response to ischemia", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q99MQ3-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UK78-1", "uniprot_id": [ { "id": "PCGF5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UK78", "type": "external" } ], "mass": 29657.0, "length": 256, "protein_name": "Polycomb group RING finger protein 5", "gene_name": "Pcgf5", "organism": "Mouse", "refseq_name": "polycomb group RING finger protein 5 isoform 2", "refseq_ac": [ { "id": "NP_083784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083784", "type": "external" } ], "gene_names_uniprotkb": "Pcgf5; Rnf159", "gene_names_refseq": "0610009F02Rik; 1110054A01Rik; 5830406C17Rik; 5830443C21Rik; 9530023M17Rik; Pcgf5", "protein_names_uniprotkb": "Polycomb group RING finger protein 5; RING finger protein 159", "protein_names_refseq": "RING finger protein 159; polycomb group RING finger protein 5 isoform 2; polycomb group RING finger protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:76073); (R-MMU-8939243)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;27136092;28596365;32130724", "class_list": "", "function": "Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:27136092, PubMed:28596365). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity). Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (PubMed:28596365)., [UniProtKB, PubMed, UniProtKB, PubMed]; Polycomb group RING finger protein 5 influences several developmental signaling pathways during the in vitro differentiation of mouse embryonic stem cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RTD3;B7ZP23;Q9D3E5;Q9DCW8", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140862 histone H2AK119 ubiquitin ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0031519 PcG protein complex", "go_biological_process": "GO:0060816 random inactivation of X chromosome;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3UK78-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4VAC9-1", "uniprot_id": [ { "id": "PKHG3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4VAC9", "type": "external" } ], "mass": 148519.0, "length": 1341, "protein_name": "Pleckstrin homology domain-containing family G member 3", "gene_name": "Plekhg3", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family G member 3 isoform 2", "refseq_ac": [ { "id": "NP_722499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722499", "type": "external" } ], "gene_names_uniprotkb": "Plekhg3; Kiaa0599", "gene_names_refseq": "Plekhg3", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family G member 3; PH domain-containing family G member 3", "protein_names_refseq": "PH domain-containing family G member 3; pleckstrin homology domain-containing family G member 3 isoform 2; pleckstrin homology domain-containing family G member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:263406); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013406); (R-MMU-9013408)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "17242355;21183079;21750661;27555588;30084848;31219806;34428180", "class_list": "", "function": "PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front., [RefSeq, PubMed]; Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QL46;Q3TSI8;Q6A041;Q8BJP5;Q8K0L5;Q8K0T6", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0030334 regulation of cell migration;GO:2000114 regulation of establishment of cell polarity", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q4VAC9-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923M0-1", "uniprot_id": [ { "id": "PP16A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q923M0", "type": "external" } ], "mass": 57530.0, "length": 524, "protein_name": "Protein phosphatase 1 regulatory subunit 16A", "gene_name": "Ppp1r16a", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 16A", "refseq_ac": [ { "id": "NP_203535", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_203535", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r16a; Mypt3", "gene_names_refseq": "2900084E10Rik; Mypt3; Ppp1r16a", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 16A; Myosin phosphatase targeting subunit 3", "protein_names_refseq": "mFLJ00392 protein; myosin phosphatase targeting subunit 3; myosin phosphatase, target subunit 3; protein phosphatase 1 regulatory subunit 16A; protein phosphatase 1, regulatory (inhibitor) subunit 16A", "tax_id": 10090, "disease": "", "pathway": " (mmu:73062)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11336659;18202305;21750661", "class_list": "", "function": "Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates., [UniProtKB]; R16A at the membrane may mediate the PB signal to initiate CAR nuclear translocation, through a mechanism including its dimerization and inhibition of PP1beta activity., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4V9Z1", "ec_number_list": [], "go_molecular_function": "GO:0017020 myosin phosphatase regulator activity;GO:0004857 enzyme inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q923M0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PEB4-1", "uniprot_id": [ { "id": "OSGL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PEB4", "type": "external" } ], "mass": 44928.0, "length": 414, "protein_name": "tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial", "gene_name": "Osgepl1", "organism": "Mouse", "refseq_name": "tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial", "refseq_ac": [ { "id": "NP_001272768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272768", "type": "external" } ], "gene_names_uniprotkb": "Osgepl1", "gene_names_refseq": "2610001M19Rik; Osgepl1", "protein_names_uniprotkb": "tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; 2.3.1.234; N6-L-threonylcarbamoyladenine synthase; O-sialoglycoprotein endopeptidase-like protein 1; t(6)A synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgepl1; tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1", "protein_names_refseq": "N6-L-threonylcarbamoyladenine synthase; O-sialoglycoprotein endopeptidase-like protein 1; probable O-sialoglycoprotein endopeptidase 2; probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; probable tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1; t(6)A synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgepl1; tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:72085)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;23576753;25428506", "class_list": "", "function": "Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVG1;Q8BLB6;Q9D0N0", "ec_number_list": [ { "id": "2.3.1.234", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.234", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0061711 tRNA N(6)-L-threonylcarbamoyladenine synthase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0002949 tRNA threonylcarbamoyladenosine modification", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PEB4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25799-1", "uniprot_id": [ { "id": "NFKB1_MOUSE", "url": "https://www.uniprot.org/uniprot/P25799", "type": "external" } ], "mass": 105615.0, "length": 971, "protein_name": "Nuclear factor NF-kappa-B p105 subunit", "gene_name": "Nfkb1", "organism": "Mouse", "refseq_name": "nuclear factor NF-kappa-B p105 subunit isoform 1", "refseq_ac": [ { "id": "NP_032715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032715", "type": "external" } ], "gene_names_uniprotkb": "Nfkb1", "gene_names_refseq": "NF-KB1; NF-kappaB1; NF-kappaB; Nfkb1; p105; p50/p105; p50", "protein_names_uniprotkb": "Nuclear factor NF-kappa-B p105 subunit; DNA-binding factor KBF1; EBP-1; NF-kappa-B1 p84/NF-kappa-B1 p98; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1", "protein_names_refseq": "DNA-binding factor KBF1; EBP-1; NF kappaB1; NF-kappa-B1 p84/NF-kappa-B1 p98; NF-kappaB p50; nuclear factor NF-kappa-B p105 subunit isoform 1; nuclear factor NF-kappa-B p105 subunit; nuclear factor kappaB p50; nuclear factor of kappa light chain gene enhancer in B-cells 1, p105; p50 subunit of NF kappaB", "tax_id": 10090, "disease": "opportunistic bacterial infectious disease (Disease Ontology:DOID:0050340); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); common variable immunodeficiency 12 (Disease Ontology:DOID:0081154); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); alcoholic hepatitis (Disease Ontology:DOID:12351); neurodegenerative disease (Disease Ontology:DOID:1289); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); transient cerebral ischemia (Disease Ontology:DOID:224); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); lung non-small cell carcinoma (Disease Ontology:DOID:3908); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); hepatocellular carcinoma (Disease Ontology:DOID:684); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:18033); (R-MMU-1169091); (R-MMU-1810476); (R-MMU-193692); (R-MMU-202424); (R-MMU-209560); (R-MMU-2871837); (R-MMU-3134963); (R-MMU-3214841); (R-MMU-445989); (R-MMU-448706); (R-MMU-5607764); (R-MMU-5621575); (R-MMU-5684264); (R-MMU-6798695); (R-MMU-9020702); (R-MMU-933542); (R-MMU-9860927); (R-MMU-9958825)", "pathway_count": 19, "publication_count": 32, "publication_id_list": "11297557;11356851;11931770;11970948;11970949;12886018;1339305;15051764;15241416;17869269;18270204;21183079;21750661;2203532;22427889;25428506;26740625;28135057;30084848;32782141;34428180;36852467;39294682;39337370;7530332;7969179;8183915;8398903;9384558;9450761;9529257;9865694", "class_list": "", "function": "Acts as an inhibitor of transactivation of p50 NF-kappa-B subunit, probably by sequestering it in the cytoplasm., [UniProtKB, PubMed, PubMed]; Constitutes the active form, which associates with RELA/p65 to form the NF-kappa-B p65-p50 complex to form a transcription factor. Together with RELA/p65, binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions., [UniProtKB, UniProtKB]; Isoform 3 (p98) (but not p84 or p105) acts as a transactivator of NF-kappa-B-regulated gene expression., [UniProtKB, PubMed]; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. Plays a role in the regulation of apoptosis. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; P105 is the precursor of the active p50 subunit (Nuclear factor NF-kappa-B p50 subunit) of the nuclear factor NF-kappa-B. Acts as a cytoplasmic retention of attached NF-kappa-B proteins by p105., [UniProtKB, UniProtKB]; The NF-kappaB1/p50 Subunit Influences the Notch/IL-6-Driven Expansion of Myeloid-Derived Suppressor Cells in Murine T-Cell Acute Lymphoblastic Leukemia. Publication Status: Online-Only, [RefSeq, PubMed]; The regulation of NFKB1 on CD200R1 expression and their potential roles in Parkinson's disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 16, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B2RRQ6;Q3TZE8;Q3V2V6;Q6TDG8;Q75ZL1;Q80Y21;Q8C712", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0033256 I-kappaB/NF-kappaB complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:1904385 cellular response to angiotensin;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0010957 negative regulation of vitamin D biosynthetic process;GO:0071359 cellular response to dsRNA", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P25799-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0E1-1", "uniprot_id": [ { "id": "HNRPM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0E1", "type": "external" } ], "mass": 77649.0, "length": 729, "protein_name": "Heterogeneous nuclear ribonucleoprotein M", "gene_name": "Hnrnpm", "organism": "Mouse", "refseq_name": "heterogeneous nuclear ribonucleoprotein M isoform b", "refseq_ac": [ { "id": "NP_001103383", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103383", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpm; Hnrpm", "gene_names_refseq": "2610023M21Rik; Hnrnpm; Hnrpm; mKIAA4193", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein M; hnRNP M", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein M isoform b; hnRNP M", "tax_id": 10090, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); leiomyoma (Disease Ontology:DOID:127)", "pathway": " (mmu:76936)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "15345747;21183079;21750661;23806337;24788674;25153642;25428506;25605945;28135057;28528544;30084848;31219806;31361958;31693898;33300544;33725478;33727124;34428180;34887587;35820727;36288343;37453647;37507081;37828378;39627609", "class_list": "", "function": "HnRNPM deficiency leads to cognitive deficits via disrupting synaptic plasticity., [RefSeq, PubMed]; Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines (By similarity)., [UniProtKB]; The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P1B2;Q99JQ0", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0019904 protein domain specific binding;GO:0048306 calcium-dependent protein binding;GO:1990405 protein antigen binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0009986 cell surface", "go_biological_process": "GO:1904591 positive regulation of protein import;GO:1900182 positive regulation of protein localization to nucleus;GO:0000380 alternative mRNA splicing, via spliceosome;GO:0099175 regulation of postsynapse organization", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q9D0E1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2Y2-1", "uniprot_id": [ { "id": "MUC18_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2Y2", "type": "external" } ], "mass": 71545.0, "length": 648, "protein_name": "Cell surface glycoprotein MUC18", "gene_name": "Mcam", "organism": "Mouse", "refseq_name": "cell surface glycoprotein MUC18 isoform 1 precursor", "refseq_ac": [ { "id": "NP_075548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075548", "type": "external" } ], "gene_names_uniprotkb": "Mcam; Muc18", "gene_names_refseq": "1-gicerin; CD146; CD149; Mcam; Muc18; s-endo; s-gicerin", "protein_names_uniprotkb": "Cell surface glycoprotein MUC18; Gicerin; Melanoma cell adhesion molecule; Melanoma-associated antigen MUC18", "protein_names_refseq": "cell surface glycoprotein MUC18 isoform 1 precursor; cell surface glycoprotein MUC18; l-gicerin protein; melanoma adhesion molecule; melanoma-associated antigen MUC18", "tax_id": 10090, "disease": "malignant mesothelioma (Disease Ontology:DOID:1790); impotence (Disease Ontology:DOID:1875); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); uveal melanoma (Disease Ontology:DOID:6039)", "pathway": " (mmu:84004); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013408); (R-MMU-9013423); (R-MMU-9035034)", "pathway_count": 9, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11255016;11329371;14612940;19349973;21183079;21750661;30899004;33300544;35820727;38908086", "class_list": "", "function": "CD146-dependent macrophage infiltration promotes epidural fibrosis via the Erdr1/ERK/CCR2 pathway., [RefSeq, PubMed]; Gicerin is an effector for the malignant progression of mammary carcinoma, [RefSeq, PubMed]; Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9EPF1;Q9ESS7;Q9JHQ2;Q9JHQ3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0030335 positive regulation of cell migration;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0003094 glomerular filtration", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8R2Y2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TEA8-1", "uniprot_id": [ { "id": "HP1B3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TEA8", "type": "external" } ], "mass": 60867.0, "length": 554, "protein_name": "Heterochromatin protein 1-binding protein 3", "gene_name": "Hp1bp3", "organism": "Mouse", "refseq_name": "heterochromatin protein 1-binding protein 3 isoform 2", "refseq_ac": [ { "id": "NP_001116368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116368", "type": "external" } ], "gene_names_uniprotkb": "Hp1bp3", "gene_names_refseq": "Hp1bp3; Hp1bp74", "protein_names_uniprotkb": "Heterochromatin protein 1-binding protein 3", "protein_names_refseq": "heterochromatin protein 1-binding protein 3 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:15441)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "18299400;21750661;21952136;23806337;25428506;25428507;25605945;25662603;26740625;30084848;30549219;30779550;33300544;34428180;34887587;36288343;39627609;8978696", "class_list": "", "function": "Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity. May play a role in hypoxia-induced oncogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; Hp1bp3 is a critical mediator of aging-related changes at the phenotypic, cellular, and molecular level., [RefSeq, PubMed]; The results suggest that HP1BP3 is a ubiquitous histone H1 like nuclear protein with distinct and non-redundant functions necessary for survival and growth., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AM64;A2AM68;Q3TM38;Q3TU07;Q61688;Q8BT17;Q8C6H2;Q8C911;Q8VE06;Q99KR0;Q9DBI1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0031491 nucleosome binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005694 chromosome;GO:0000786 nucleosome", "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0006355 regulation of DNA-templated transcription;GO:0071456 cellular response to hypoxia;GO:0006334 nucleosome assembly;GO:0097298 regulation of nucleus size", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q3TEA8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VBL6-1", "uniprot_id": [ { "id": "HIF3A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0VBL6", "type": "external" } ], "mass": 73044.0, "length": 662, "protein_name": "Hypoxia-inducible factor 3-alpha", "gene_name": "Hif3a", "organism": "Mouse", "refseq_name": "hypoxia-inducible factor 3-alpha isoform 1", "refseq_ac": [ { "id": "NP_001156422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156422", "type": "external" } ], "gene_names_uniprotkb": "Hif3a; Mop7; Nepas", "gene_names_refseq": "Hif3a; Ipas; MOP7; NEPAS; bHLHe17", "protein_names_uniprotkb": "Hypoxia-inducible factor 3-alpha; Basic-helix-loop-helix-PAS protein MOP7; HIF-3-alpha; HIF3-alpha-1; HIF3-alpha; IPAS; Inhibitory PAS domain protein; Member of PAS protein 7; Neonatal and embryonic PAS protein", "protein_names_refseq": "HIF-3-alpha; HIF3-alpha-1; HIF3-alpha; basic-helix-loop-helix-PAS protein MOP7; hypoxia inducible factor three alpha; hypoxia-inducible factor 3-alpha isoform 1; hypoxia-inducible factor 3-alpha; inhibitory PAS domain protein; member of PAS protein 7; neonatal and embryonic PAS protein", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:53417); (R-MMU-1234158); (R-MMU-1234176); (R-MMU-8951664)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "11734856;12119283;17125738;17355974;18070924;21546903;21750661;24092767;34428180;34826399;35347545;38717999;9840812", "class_list": "", "function": "Acts as a positive regulator of hypoxia-inducible gene expression. Associates to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters in a ARNT-dependent manner, and hence also participates in the transcriptional activation of reporter genes driven by HRE (PubMed:9840812)., [UniProtKB, PubMed]; Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression (PubMed:11734856, PubMed:21546903, PubMed:9840812). Plays a role in the development of the cardiorespiratory system (PubMed:18070924)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Alternative splicing and expression of IPAS is induced by hypoxia., [RefSeq, PubMed]; Attenuates the ability of transcription factor HIF1A, EPAS1 and the HIF1A-ARNT complex to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. May act as a tumor suppressor (PubMed:11734856). May also be involved in apoptosis (PubMed:21546903)., [UniProtKB, PubMed, PubMed, PubMed]; Genetic variants of the hypoxia-inducible factor 3 alpha subunit (Hif3a) gene in the Fat and Lean mouse selection lines., [RefSeq, PubMed]; HIF3A gene disruption causes abnormal alveoli structure and early neonatal death. Publication Status: Online-Only, [RefSeq, PubMed]; Hypoxia inducible factor-3alpha promotes osteosarcoma progression by activating KDM3A-mediated demethylation of SOX9., [RefSeq, PubMed]; Identity of third HIF alpha class member, HIF-3alpha. mRNA expression information by mouse MTN. Experimental proof of dimerization with ARNT/HIF-1beta., [RefSeq, PubMed]; These data suggest an involvement of the HIF system in metabolic derangements as for instance caused by diabetes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1IM61;E9QLB1;Q3UN40;Q8VHR1;Q9QX54;Q9Z2I5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0001525 angiogenesis;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001666 response to hypoxia;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q0VBL6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59644-1", "uniprot_id": [ { "id": "PI5PA_MOUSE", "url": "https://www.uniprot.org/uniprot/P59644", "type": "external" } ], "mass": 107544.0, "length": 1003, "protein_name": "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A", "gene_name": "Inpp5j", "organism": "Mouse", "refseq_name": "phosphatidylinositol 4,5-bisphosphate 5-phosphatase A", "refseq_ac": [ { "id": "NP_766027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766027", "type": "external" } ], "gene_names_uniprotkb": "Inpp5j; Pib5pa", "gene_names_refseq": "Inpp5j; Pib5pa; Pipp", "protein_names_uniprotkb": "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; 3.1.3.36; 3.1.3.56; Inositol polyphosphate 5-phosphatase J; Phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase; Phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase", "protein_names_refseq": "phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A; phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase; phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase; phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; proline-rich inositol polyphosphate 5-phosphatase", "tax_id": 10090, "disease": "", "pathway": " (mmu:170835); (R-MMU-1660499); (R-MMU-1855183); (R-MMU-1855204)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10.3389/fragi.2021.757801;12536145;20173027;21183079;21750661;22517741;24129315;30059200;33537929;34678516;35822049;40021952;40885482", "class_list": "", "function": "Hormesis of low-dose inhibition of pAkt1 (Ser473) followed by a great increase of proline-rich inositol polyphosphate 5-phosphatase (PIPP) level in oocytes., [RefSeq, PubMed]; Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDM9", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "2.7.1.134", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.134", "type": "external" }, { "id": "2.7.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.159", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" } ], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0004445 inositol-polyphosphate 5-phosphatase activity;GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity;GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030426 growth cone;GO:0043198 dendritic shaft;GO:0043005 neuron projection", "go_biological_process": "GO:0010977 negative regulation of neuron projection development;GO:0033137 negative regulation of peptidyl-serine phosphorylation;GO:0046856 phosphatidylinositol dephosphorylation;GO:0031115 negative regulation of microtubule polymerization", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P59644-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGN5-1", "uniprot_id": [ { "id": "PLIN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CGN5", "type": "external" } ], "mass": 55596.0, "length": 517, "protein_name": "Perilipin-1", "gene_name": "Plin1", "organism": "Mouse", "refseq_name": "perilipin-1", "refseq_ac": [ { "id": "NP_001106942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106942", "type": "external" } ], "gene_names_uniprotkb": "Plin1; Peri; Plin", "gene_names_refseq": "6030432J05Rik; Peri; Plin1; Plin", "protein_names_uniprotkb": "Perilipin-1; Lipid droplet-associated protein; Perilipin A", "protein_names_refseq": "lipid droplet-associated protein; perilipin A; perilipin B; perilipin-1", "tax_id": 10090, "disease": "familial partial lipodystrophy type 4 (Disease Ontology:DOID:0070205); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:103968)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11641724;11751901;12407111;15292255;19921680;21183079;21750661;23481402;24945349;31924761;34428180", "class_list": "", "function": "Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness (By similarity). Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels., [UniProtKB, PubMed]; Perilipin expression and phosphorylation state are critical regulators of lipid storage and hydrolysis in ACS1/FATP1 cells., [RefSeq, PubMed]; The central 25% of the perilipin A sequence contains all of the amino acids necessary to target and anchor the protein to lipid droplets, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4V9U2;Q8C0F5", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0070417 cellular response to cold;GO:0016042 lipid catabolic process;GO:0010897 negative regulation of triglyceride catabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8CGN5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLM4-1", "uniprot_id": [ { "id": "ZMYM3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLM4", "type": "external" } ], "mass": 152879.0, "length": 1370, "protein_name": "Zinc finger MYM-type protein 3", "gene_name": "Zmym3", "organism": "Mouse", "refseq_name": "zinc finger MYM-type protein 3 isoform 1", "refseq_ac": [ { "id": "NP_062805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062805", "type": "external" } ], "gene_names_uniprotkb": "Zmym3; Kiaa0385; Zfp261; Znf261", "gene_names_refseq": "9030216B10Rik; DXS6673El; Zfp261; Zmym3", "protein_names_uniprotkb": "Zinc finger MYM-type protein 3; DXHXS6673E protein; Zinc finger protein 261", "protein_names_refseq": "zinc finger MYM-type protein 3 isoform 1; zinc finger MYM-type protein 3; zinc finger protein 261", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776)", "pathway": " (mmu:56364)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10662551;21183079;21750661;28661483;34428180", "class_list": "", "function": "Required for regulation of cell morphology and cytoskeletal organization., [UniProtKB, UniProtKB]; Zmym3 KO also resulted in up-regulated expression of meiotic genes in spermatogonia. These results show that ZMYM3 has an essential role in metaphase to anaphase transition during mouse spermatogenesis by regulating the expression of diverse families of genes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80U17", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0007010 cytoskeleton organization;GO:0022604 regulation of cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JLM4-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D5L7-1", "uniprot_id": [ { "id": "SPSB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D5L7", "type": "external" } ], "mass": 30785.0, "length": 273, "protein_name": "SPRY domain-containing SOCS box protein 1", "gene_name": "Spsb1", "organism": "Mouse", "refseq_name": "SPRY domain-containing SOCS box protein 1", "refseq_ac": [ { "id": "NP_083311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083311", "type": "external" } ], "gene_names_uniprotkb": "Spsb1; Ssb1", "gene_names_refseq": "1110014L01Rik; 4930422J18Rik; SSB-1; SSB1; Spsb1", "protein_names_uniprotkb": "SPRY domain-containing SOCS box protein 1; SSB-1", "protein_names_refseq": "SPRY domain-containing SOCS box protein 1; SPRY domain-containing SOCS box protein SSB-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74646); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "16369487;16498413;19101625;20561531;20603330;21750661;24786206;26032413;28270450;31085591;37209006", "class_list": "", "function": "Collectively, Ssb1 and Ssb2 control crucial aspects of Hematopoietic stem and progenitor cells function, including proliferation and survival in vivo by resolving replicative stress to maintain genomic stability., [RefSeq, PubMed]; Findings define a novel pathway that contributes to breast cancer recurrence and provide evidence implicating SPSB proteins in cancer., [RefSeq, PubMed]; SPSB1 and SPSB4 bind strongly to both Par-4 and VASA peptides., [RefSeq, PubMed]; SPSB1 negatively regulates the TGF-beta signaling pathway through its interaction with both endogenous and overexpressed TbetaRII (and not TbetaRI) via its Spry domain., [RefSeq, PubMed]; SPSB1-mediated inhibition of TGF-beta receptor-II impairs myogenesis in inflammation., [RefSeq, PubMed]; Spsb1 is responsive to stress caused by ethanol exposure in the mouse brain, which suggests that Spsb genes have acquired different regulatory mechanisms., [RefSeq, PubMed]; Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (By similarity). Acts as a bridge which links the NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity)., [UniProtKB, UniProtKB]; These results establish SSB1/2 as safeguards of B cell development and unveil their differential requirement in immature and mature B lymphocytes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5FWI0;Q8BJA4", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9D5L7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80W88-1", "uniprot_id": [ { "id": "HOMEZ_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80W88", "type": "external" } ], "mass": 60914.0, "length": 542, "protein_name": "Homeobox and leucine zipper protein Homez", "gene_name": "Homez", "organism": "Mouse", "refseq_name": "homeobox and leucine zipper protein Homez isoform 1", "refseq_ac": [ { "id": "NP_001171176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171176", "type": "external" } ], "gene_names_uniprotkb": "Homez; Kiaa1443", "gene_names_refseq": "Homez; mKIAA1443", "protein_names_uniprotkb": "Homeobox and leucine zipper protein Homez; Homeodomain leucine zipper-containing factor", "protein_names_refseq": "homeobox and leucine zipper protein Homez isoform 1; homeobox and leucine zipper protein Homez; homeodomain leucine zipper-containing factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:239099)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12925734;21750661;25428506;30084848;34428180", "class_list": "", "function": "May function as a transcriptional regulator., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q504Z8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80W88-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62077-1", "uniprot_id": [ { "id": "PLCG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62077", "type": "external" } ], "mass": 149668.0, "length": 1302, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "gene_name": "Plcg1", "organism": "Mouse", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "refseq_ac": [ { "id": "NP_067255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067255", "type": "external" } ], "gene_names_uniprotkb": "Plcg1; Plcg-1", "gene_names_refseq": "Cded; Plc-1; Plc-gamma1; Plcg-1; Plcg1", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; 3.1.4.11; PLC-gamma-1; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-gamma-1", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; PLC-gamma-1; cell differentiation and embryonic development; phosphoinositide phospholipase C-gamma-1", "tax_id": 10090, "disease": "familial adenomatous polyposis (Disease Ontology:DOID:0050424); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); Alzheimer's disease (Disease Ontology:DOID:10652); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (mmu:18803); (R-MMU-1169408); (R-MMU-1855204); (R-MMU-186763); (R-MMU-201556); (R-MMU-202433); (R-MMU-2029485); (R-MMU-210990); (R-MMU-212718); (R-MMU-2424491); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-5218921); (R-MMU-5654219); (R-MMU-5654221); (R-MMU-5654227); (R-MMU-5654228); (R-MMU-8853659); (R-MMU-9026527); (R-MMU-9034793)", "pathway_count": 20, "publication_count": 38, "publication_id_list": "10646608;10748127;11463797;12367511;12730118;15308098;15592455;15629145;16000869;1646396;1708307;1714377;17620338;17635937;17947660;18034455;18515860;19542227;19597499;21262971;21750661;22561606;24317039;24843022;25428506;25605945;28528544;29388468;30084848;30779550;34203471;34428180;35920844;39159149;39478550;8687404;8943348;9299537", "class_list": "", "function": "A non-catalytic role of IPMK is required for PLCgamma1 activation in T cell receptor signaling by stabilizing the PLCgamma1-Sam68 complex. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (By similarity). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; PLCgamma1 deficiency in chondrocytes accelerates the age-related changes in articular cartilage and subchondral bone., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P1G1", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "6.3.2.n3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.n3", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005158 insulin receptor binding;GO:0019901 protein kinase binding;GO:0004629 phospholipase C activity;GO:0051219 phosphoprotein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0032959 inositol trisphosphate biosynthetic process;GO:1905564 positive regulation of vascular endothelial cell proliferation;GO:1904643 response to curcumin;GO:0031161 phosphatidylinositol catabolic process;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "Q62077-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PFX7-1", "uniprot_id": [ { "id": "NYAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PFX7", "type": "external" } ], "mass": 87668.0, "length": 833, "protein_name": "Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1", "gene_name": "Nyap1", "organism": "Mouse", "refseq_name": "neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform 2", "refseq_ac": [ { "id": "NP_001334434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334434", "type": "external" } ], "gene_names_uniprotkb": "Nyap1; 6430598A04Rik", "gene_names_refseq": "6430598A04Rik; Nyap1", "protein_names_uniprotkb": "Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1", "protein_names_refseq": "neuronal tyrosine phosphorylated adaptor for phosphoinositide 3-kinase adaptor 1; neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform 2; neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:243300)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;21946561;22517741;22645316;31609430;32848054;34678516", "class_list": "", "function": "Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis., [UniProtKB, PubMed]; Nyap1 Regulates Multipolar-Bipolar Transition and Morphology of Migrating Neurons by Fyn Phosphorylation during Corticogenesis., [RefSeq, PubMed]; Phosphorylated NYAPs interact with PI3K p85 and activate PI3K, Akt, and Rac1. Moreover, the NYAPs interact with the WAVE1 complex which mediates remodelling of the actin cytoskeleton after activation by PI3K-produced PIP3 and Rac1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E1CB66;Q3UF51;Q8BNR4;Q8CCL6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0048812 neuron projection morphogenesis;GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6PFX7-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925Q3-1", "uniprot_id": [ { "id": "NCLX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q925Q3", "type": "external" } ], "mass": 64365.0, "length": 585, "protein_name": "Mitochondrial sodium/calcium exchanger protein", "gene_name": "Slc8b1", "organism": "Mouse", "refseq_name": "mitochondrial sodium/calcium exchanger protein isoform 2 precursor", "refseq_ac": [ { "id": "NP_001171065", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171065", "type": "external" } ], "gene_names_uniprotkb": "Slc8b1; Nckx6; Nclx; Slc24a6", "gene_names_refseq": "NCKX6; NCLX; Slc24a6; Slc8b1", "protein_names_uniprotkb": "Mitochondrial sodium/calcium exchanger protein; Na(+)/K(+)/Ca(2+)-exchange protein 6; Sodium/calcium exchanger protein, mitochondrial; Sodium/potassium/calcium exchanger 6; Solute carrier family 24 member 6; Solute carrier family 8 member B1", "protein_names_refseq": "Na(+)/K(+)/Ca(2+)-exchange protein 6; mitochondrial sodium/calcium exchanger protein isoform 2 precursor; mitochondrial sodium/calcium exchanger protein; sodium/calcium exchanger protein, mitochondrial; sodium/potassium/calcium exchanger 6, mitochondrial; solute carrier family 24 (sodium/potassium/calcium exchanger), member 6; solute carrier family 24 member 6; solute carrier family 8 member B1", "tax_id": 10090, "disease": "", "pathway": " (mmu:170756); (R-MMU-425561); (R-MMU-8949215)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11940515;12080145;12270979;12767888;12832517;14625281;20018762;21750661;22677781;24067497;26740625;27328625;28445457;38960129", "class_list": "", "function": "An electrophysiologically distinct subset of arcuate nucleus neurons coexpress orexin receptors and glutamate decarboxylase-67 and are excited by orexin, activating a sodium-calcium exchange current, thereby depolarizing the cell and increasing its firing, [RefSeq, PubMed]; Ca(2+) entering the myocyte via NCX can cause Ca(2+) sparks which are similar to those elicited by electrical stimulation. However, Ca(2+) influx on NCX is much less efficient in inducing Ca(2+) sparks than Ca(2+) influx via I(Ca,L)., [RefSeq, PubMed]; Data provide evidence for the presence of an electrogenic Na(+)/Ca(2+) exchanger that is capable of regulating [Ca(2+)](i) after release of Ca(2+) from cell stores, [RefSeq, PubMed]; Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:28445457). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (PubMed:24067497, PubMed:28445457). Mitochondrial calcium export is ph-dependent (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (By similarity). Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (By similarity). Involved in B-lymphocyte chemotaxis (PubMed:27328625). Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange (By similarity). In contrast to other members of the family its function is independent of K(+) (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; NCLX controls hepatic mitochondrial Ca[2+] extrusion and couples hormone-mediated mitochondrial Ca[2+] oscillations with gluconeogenesis., [RefSeq, PubMed]; Presence of a Na(+)-Ca(2+) exchanger in podocytes and its regulation by PKC., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U067;Q80XM7", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0005432 calcium:sodium antiporter activity;GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential;GO:0015297 antiporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0042593 glucose homeostasis;GO:0050796 regulation of insulin secretion;GO:0035725 sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q925Q3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54714-1", "uniprot_id": [ { "id": "PIAS3_MOUSE", "url": "https://www.uniprot.org/uniprot/O54714", "type": "external" } ], "mass": 68318.0, "length": 628, "protein_name": "E3 SUMO-protein ligase PIAS3", "gene_name": "Pias3", "organism": "Mouse", "refseq_name": "E3 SUMO-protein ligase PIAS3 isoform 3", "refseq_ac": [ { "id": "NP_001159421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159421", "type": "external" } ], "gene_names_uniprotkb": "Pias3", "gene_names_refseq": "Pias3l; Pias3", "protein_names_uniprotkb": "E3 SUMO-protein ligase PIAS3; 2.3.2.-; E3 SUMO-protein transferase PIAS3; Protein inhibitor of activated STAT protein 3", "protein_names_refseq": "E3 SUMO-protein ligase PIAS3 isoform 3; E3 SUMO-protein ligase PIAS3; E3 SUMO-protein transferase PIAS3; protein inhibitor of activated STAT protein 3", "tax_id": 10090, "disease": "hematologic cancer (Disease Ontology:DOID:2531)", "pathway": " (mmu:229615); (R-MMU-3232118); (R-MMU-3899300); (R-MMU-4090294); (R-MMU-4615885); (R-MMU-4755510); (R-MMU-5696395)", "pathway_count": 7, "publication_count": 19, "publication_id_list": "10854042;11060035;11117529;11390395;11709556;12077349;12208521;12387893;12855578;14596924;18681895;21750661;30630513;31219806;32398867;34428180;36852467;38733503;9388184", "class_list": "", "function": "Cancer exosome-derived miR-9 and miR-181a promote the development of early-stage MDSCs via interfering with SOCS3 and PIAS3 respectively in breast cancer., [RefSeq, PubMed]; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Repressor of STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Repressor of MITF transcriptional activity. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 which promotes its interaction with SIRT1 (By similarity). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Knocking Down PIAS3 Reduces H2O2-induced Oxidative Stress Injury in HT22 Cells., [RefSeq, PubMed]; PIAS3 could have therapeutic benefits in patients with Spondyloarthritis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q80WF8;Q8R598", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0008270 zinc ion binding;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "O54714-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80Y17-1", "uniprot_id": [ { "id": "L2GL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80Y17", "type": "external" } ], "mass": 112618.0, "length": 1036, "protein_name": "Lethal(2) giant larvae protein homolog 1", "gene_name": "Llgl1", "organism": "Mouse", "refseq_name": "lethal(2) giant larvae protein homolog 1 isoform 3", "refseq_ac": [ { "id": "NP_001152876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152876", "type": "external" } ], "gene_names_uniprotkb": "Llgl1; Llglh", "gene_names_refseq": "Lgl1; Llgl1; Llglh; Mgl1", "protein_names_uniprotkb": "Lethal(2) giant larvae protein homolog 1; LLGL; Mgl-1; Mlgl", "protein_names_refseq": "LLGL; lethal giant larvae homolog 1; lethal(2) giant larvae protein homolog 1 isoform 3; lethal(2) giant larvae protein homolog 1; mgl-1; mlgl", "tax_id": 10090, "disease": "brain cancer (Disease Ontology:DOID:1319); cancer (Disease Ontology:DOID:162); kidney cancer (Disease Ontology:DOID:263); carcinoma (Disease Ontology:DOID:305); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (mmu:16897)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11809830;12629547;15037549;17525332;19144319;20173027;21183079;21750661;34428180;35172155;35820727;37828378;38526932;8103190", "class_list": "", "function": "Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane., [UniProtKB, UniProtKB, UniProtKB]; LGL1 binds to Integrin beta1 and inhibits downstream signaling to promote epithelial branching in the mammary gland., [RefSeq, PubMed]; Role of LGL1 in cerebellar primordium of embryonic mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q61856;Q7TNV3;Q8BN92", "ec_number_list": [], "go_molecular_function": "GO:0045159 myosin II binding;GO:0005096 GTPase activator activity;GO:0019901 protein kinase binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0035748 myelin sheath abaxonal region;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0051294 establishment of spindle orientation;GO:0032878 regulation of establishment or maintenance of cell polarity;GO:0007409 axonogenesis;GO:0007420 brain development;GO:0030866 cortical actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q80Y17-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CBD1-1", "uniprot_id": [ { "id": "NRIP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CBD1", "type": "external" } ], "mass": 126337.0, "length": 1161, "protein_name": "Nuclear receptor-interacting protein 1", "gene_name": "Nrip1", "organism": "Mouse", "refseq_name": "nuclear receptor-interacting protein 1", "refseq_ac": [ { "id": "NP_775616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775616", "type": "external" } ], "gene_names_uniprotkb": "Nrip1", "gene_names_refseq": "6030458L20Rik; 8430438I05Rik; 9630050P12; Nrip1; RIP140", "protein_names_uniprotkb": "Nuclear receptor-interacting protein 1; Nuclear factor RIP140; Receptor-interacting protein 140", "protein_names_refseq": "nuclear factor RIP140; nuclear receptor-interacting protein 1; receptor-interacting protein 140", "tax_id": 10090, "disease": "congenital anomalies of the kidney and urinary tract (Disease Ontology:DOID:0080205); osteoporosis (Disease Ontology:DOID:11476)", "pathway": " (mmu:268903); (R-MMU-3899300); (R-MMU-9018519)", "pathway_count": 3, "publication_count": 26, "publication_id_list": "10531331;11006275;11100122;11278635;12549917;15130509;15155905;15846843;15879431;15919748;17187077;18682553;21628546;21750661;25428506;25605945;28381549;29233969;30084848;31219806;34428180;37482187;38047488;38459621;39125645;9774688", "class_list": "", "function": "Crosstalk between corepressor NRIP1 and cAMP signaling on adipocyte thermogenic programming., [RefSeq, PubMed]; MiR-499 enhances Porphyromonas gingivalis LPS-induced inflammatory response in macrophages by targeting NRIP1 via JAK/STAT pathway., [RefSeq, PubMed]; Modulates transcriptional repression by nuclear hormone receptors such as NR2C1, thyroid hormone receptor and retinoic acid receptor/RARA. Essential for cumulus expansion and follicle rupture during ovulation. Also controls the balance between fat accumulation and energy expenditure. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (PubMed:11100122). Plays a role in renal development (PubMed:28381549)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; RIP140 regulates transcription factor HES1 oscillatory expression and mitogenic activity in colon cancer cells., [RefSeq, PubMed]; The Regulation of Frontal Cortex Cholesterol Metabolism Abnormalities by NR3C1/NRIP1/NR1H2 Is Involved in the Occurrence of Stress-Induced Depression. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U166;Q8C3Y8;Q9Z2K2", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0005102 signaling receptor binding;GO:0003714 transcription corepressor activity;GO:0035259 nuclear glucocorticoid receptor binding;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0001543 ovarian follicle rupture;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q8CBD1-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09000-1", "uniprot_id": [ { "id": "NCOA3_MOUSE", "url": "https://www.uniprot.org/uniprot/O09000", "type": "external" } ], "mass": 151574.0, "length": 1398, "protein_name": "Nuclear receptor coactivator 3", "gene_name": "Ncoa3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ncoa3; Aib1; Pcip; Rac3; Tram1", "gene_names_refseq": "", "protein_names_uniprotkb": "Nuclear receptor coactivator 3; 2.3.1.48; ACTR; AIB-1; Amplified in breast cancer-1 protein homolog; CBP-interacting protein; NCoA-3; RAC-3; Receptor-associated coactivator 3; SRC-3; Steroid receptor coactivator protein 3; TRAM-1; Thyroid hormone receptor activator molecule 1; p/CIP; pCIP", "protein_names_refseq": "", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); breast carcinoma (Disease Ontology:DOID:3459); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:17979); (R-MMU-5687128); (R-MMU-9018519)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10381882;10823921;11701890;12709428;19144319;21183079;21750661;23019124;23806337;24129315;26495903;31219806;34428180;36852467;9192892", "class_list": "", "function": "Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, probably via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q9CRD5", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "1.14.11.68", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.68", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "1.14.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.1", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" }, { "id": "2.1.1.356", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.356", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.199", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.199", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" }, { "id": "4.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0046983 protein dimerization activity;GO:0044877 protein-containing complex binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0070561 vitamin D receptor signaling pathway;GO:1902459 positive regulation of stem cell population maintenance;GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression;GO:0030307 positive regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "O09000-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BKZ9-1", "uniprot_id": [ { "id": "ODPX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BKZ9", "type": "external" } ], "mass": 53999.0, "length": 501, "protein_name": "Pyruvate dehydrogenase protein X component, mitochondrial", "gene_name": "Pdhx", "organism": "Mouse", "refseq_name": "pyruvate dehydrogenase protein X component, mitochondrial", "refseq_ac": [ { "id": "NP_780303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780303", "type": "external" } ], "gene_names_uniprotkb": "Pdhx", "gene_names_refseq": "E3bp; Pdhx; Pdx1", "protein_names_uniprotkb": "Pyruvate dehydrogenase protein X component, mitochondrial; Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; Lipoyl-containing pyruvate dehydrogenase complex component X", "protein_names_refseq": "dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex (E3-binding protein) (proX); lipoyl-containing pyruvate dehydrogenase complex component X; pyruvate dehydrogenase protein X component, mitochondrial", "tax_id": 10090, "disease": "sarcoma (Disease Ontology:DOID:1115); pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649)", "pathway": " (mmu:27402); (R-MMU-204174); (R-MMU-5362517); (R-MMU-9861559)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "12853470;21750661;22872234;23806337;25428506;34428180;36288343;37507081;39927985", "class_list": "", "function": "Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex (By similarity)., [UniProtKB]; T1a/podoplanin is first expressed in prox 1-positive lymphatic progenitor cells, with predominant localization in the luminal plasma membrane of lymphatic endothelial cells during later development., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005886 plasma membrane;GO:0045254 pyruvate dehydrogenase complex", "go_biological_process": "GO:0006086 pyruvate decarboxylation to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BKZ9-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64143-1", "uniprot_id": [ { "id": "P55G_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64143", "type": "external" } ], "mass": 54474.0, "length": 461, "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit gamma", "gene_name": "Pik3r3", "organism": "Mouse", "refseq_name": "phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1", "refseq_ac": [ { "id": "NP_853616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_853616", "type": "external" } ], "gene_names_uniprotkb": "Pik3r3", "gene_names_refseq": "Pik3r3; p55pik; p55", "protein_names_uniprotkb": "Phosphatidylinositol 3-kinase regulatory subunit gamma; PI3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3K regulatory subunit gamma; Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; PtdIns-3-kinase regulatory subunit gamma; PtdIns-3-kinase regulatory subunit p55-gamma; p55PIK", "protein_names_refseq": "PI3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3K regulatory subunit gamma; phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55); phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1; phosphatidylinositol 3-kinase regulatory subunit gamma; ptdIns-3-kinase regulatory subunit gamma; ptdIns-3-kinase regulatory subunit p55-gamma", "tax_id": 10090, "disease": "colon adenocarcinoma (Disease Ontology:DOID:234); high grade glioma (Disease Ontology:DOID:3070); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:18710); (R-MMU-114604); (R-MMU-1257604); (R-MMU-1266695); (R-MMU-1433557); (R-MMU-1660499); (R-MMU-389357); (R-MMU-416476); (R-MMU-512988); (R-MMU-6811558); (R-MMU-8853659); (R-MMU-9009391); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-912526); (R-MMU-912631); (R-MMU-9927354)", "pathway_count": 17, "publication_count": 4, "publication_id_list": "21750661;37527538;38618953;7542745", "class_list": "", "function": "Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1., [UniProtKB]; P55gamma degrades RIP3 via MG53 to suppress ischaemia-induced myocardial necroptosis and mediates cardioprotection of preconditioning., [RefSeq, PubMed]; VHL governs m6A modification and PIK3R3 mRNA stability in clear cell renal cell carcinomas. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0046935 1-phosphatidylinositol-3-kinase regulator activity", "go_cellular_component": "GO:0005942 phosphatidylinositol 3-kinase complex;GO:0005943 phosphatidylinositol 3-kinase complex, class IA", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0008286 insulin receptor signaling pathway;GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0002042 cell migration involved in sprouting angiogenesis;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q64143-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P8G8-1", "uniprot_id": [ { "id": "ORAI3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P8G8", "type": "external" } ], "mass": 31358.0, "length": 290, "protein_name": "Protein orai-3", "gene_name": "Orai3", "organism": "Mouse", "refseq_name": "protein orai-3", "refseq_ac": [ { "id": "NP_940816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940816", "type": "external" } ], "gene_names_uniprotkb": "Orai3; Tmem142c", "gene_names_refseq": "9930124N15; Orai3; Tmem142c", "protein_names_uniprotkb": "Protein orai-3; Transmembrane protein 142C", "protein_names_refseq": "calcium release-activated calcium channel 3; protein orai-3; transmembrane protein 142C", "tax_id": 10090, "disease": "hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:269999)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21750661;26160956;33849280;35861698;36803766", "class_list": "", "function": "Cardiac-Specific Deletion of Orai3 Leads to Severe Dilated Cardiomyopathy and Heart Failure in Mice., [RefSeq, PubMed]; ORAI3 is dispensable for store-operated Ca2+ entry and immune responses by lymphocytes and macrophages., [RefSeq, PubMed]; Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells. Publication Status: Online-Only, [RefSeq, PubMed]; Pore-forming subunit of two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels. Assembles with ORAI1 and ORAI2 to form hexameric CRAC channels that mediate Ca(2+) influx upon depletion of endoplasmic reticulum Ca(2+) store and channel activation by Ca(2+) sensor STIM1, a process known as store-operated Ca(2+) entry (SOCE). Various pore subunit combinations may account for distinct CRAC channel spatiotemporal and cell-type specific dynamics. ORAI1 mainly contributes to the generation of Ca(2+) plateaus involved in sustained Ca(2+) entry and is dispensable for cytosolic Ca(2+) oscillations, whereas ORAI2 and ORAI3 generate oscillatory patterns. CRAC channels assemble in Ca(2+) signaling microdomains where Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT transcription factors recruited to ORAI1 via AKAP5. CRAC channels are the main pathway for Ca(2+) influx in T cells and promote the immune response to pathogens by activating NFAT-dependent cytokine and chemokine transcription. Assembles with ORAI1 to form channels that mediate store-independent Ca(2+) influx in response to inflammatory metabolites arachidonate or its derivative leukotriene C4, termed ARC and LRC channels respectively., [UniProtKB, UniProtKB]; VEGF signaling via arachidonic acid and arachidonic acid metabolism causes Orai3 to accumulate at the cell surface to mediate Ca(2+) entry and downstream endothelial cell remodeling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0015279 store-operated calcium channel activity;GO:0005262 calcium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0002115 store-operated calcium entry", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6P8G8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B7Z2-1", "uniprot_id": [ { "id": "OSBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3B7Z2", "type": "external" } ], "mass": 88797.0, "length": 805, "protein_name": "Oxysterol-binding protein 1", "gene_name": "Osbp", "organism": "Mouse", "refseq_name": "oxysterol-binding protein 1", "refseq_ac": [ { "id": "NP_001028346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028346", "type": "external" } ], "gene_names_uniprotkb": "Osbp; Kiaa4220", "gene_names_refseq": "1110018F06Rik; Osbp; mKIAA4220", "protein_names_uniprotkb": "Oxysterol-binding protein 1", "protein_names_refseq": "oxysterol-binding protein 1", "tax_id": 10090, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:76303); (R-MMU-192105)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "17242355;18450749;18630941;19144319;21183079;22609461;26576957;29514919;37507081", "class_list": "", "function": "Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol (cholesterol) with phosphatidylinositol 4-phosphate (PI4P, 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)), which is subsequently degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing the stability of the relatively short lived ABCA1 protein (an important point of control for cholesterol efflux activity)., [UniProtKB, UniProtKB]; OSBP may be a target and downstream effector of miR-124 for regulating neurite outgrowth and elongation., [RefSeq, PubMed]; OSBP opposes the activity of LXR by negatively regulating ABCA1 activity in the cytoplasm by sterol-binding domain-dependent protein destabilization, [RefSeq, PubMed]; Roles of different ORP proteins as regulators of macrophage lipid composition, with implications for inflammatory signaling, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QPD4;Q3V163;Q52KH7;Q570Y8", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0032934 sterol binding;GO:0120013 lipid transfer activity;GO:0120015 sterol transfer activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:0006869 lipid transport;GO:0035627 ceramide transport;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0015914 phospholipid transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q3B7Z2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CCJ9-6", "uniprot_id": [ { "id": "P20L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CCJ9", "type": "external" } ], "mass": 113860.0, "length": 1013, "protein_name": "PHD finger protein 20-like protein 1", "gene_name": "Phf20l1", "organism": "Mouse", "refseq_name": "PHD finger protein 20-like protein 1 isoform 3", "refseq_ac": [ { "id": "NP_001074878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074878", "type": "external" } ], "gene_names_uniprotkb": "Phf20l1", "gene_names_refseq": "CGI-72; E130113K22Rik; Phf20l1", "protein_names_uniprotkb": "PHD finger protein 20-like protein 1", "protein_names_refseq": "PHD finger protein 20-like protein 1 isoform 3; PHD finger protein 20-like protein 1; tudor domain-containing protein PHF20L1", "tax_id": 10090, "disease": "", "pathway": " (mmu:239510); (R-MMU-9772755)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21183079;25428506;29358331;34428180", "class_list": "", "function": "Is a negative regulator of proteasomal degradation of a set of methylated proteins, including DNMT1 and SOX2 (By similarity). Involved in the maintainance of embryonic stem cells pluripotency, through the regulation of SOX2 levels (PubMed:29358331)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H5Y9;Q80UN6;Q8BPP8;Q8BQQ6;Q8BS11;Q8C8H9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140034 methylation-dependent protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0044545 NSL complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization;GO:0042177 negative regulation of protein catabolic process;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CCJ9-6", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D404-1", "uniprot_id": [ { "id": "OXSM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D404", "type": "external" } ], "mass": 48628.0, "length": 459, "protein_name": "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial", "gene_name": "Oxsm", "organism": "Mouse", "refseq_name": "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_081971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081971", "type": "external" } ], "gene_names_uniprotkb": "Oxsm", "gene_names_refseq": "4933425A18Rik; Oxsm", "protein_names_uniprotkb": "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; 2.3.1.41; Beta-ketoacyl-ACP synthase", "protein_names_refseq": "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor; 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; beta-ketoacyl-ACP synthase", "tax_id": 10090, "disease": "", "pathway": " (mmu:71147); (R-MMU-9837999)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "23576753;23806337;30871779;37507081", "class_list": "", "function": "LA (alpha-lipoic acid) deficiency was observed with a reduction in lipoylation of pyruvate dehydrogenase in the kidney of streptozotocin-induced diabetic mice. Proteins of three enzymes (MCAT, OXSM and LIAS) in the LA synthetic pathway were examined in the kidney. A reduction was observed in OXSM, but not in the other two., [RefSeq, PubMed]; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "1.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100", "type": "external" }, { "id": "1.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.39", "type": "external" }, { "id": "2.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.38", "type": "external" }, { "id": "2.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.39", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "2.3.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.85", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "4.2.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.59", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": 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"https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006637 acyl-CoA metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0051792 medium-chain fatty acid biosynthetic process;GO:0051790 short-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D404-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DC50-1", "uniprot_id": [ { "id": "OCTC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DC50", "type": "external" } ], "mass": 70264.0, "length": 612, "protein_name": "Peroxisomal carnitine O-octanoyltransferase", "gene_name": "Crot", "organism": "Mouse", "refseq_name": "peroxisomal carnitine O-octanoyltransferase isoform a", "refseq_ac": [ { "id": "NP_076222", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076222", "type": "external" } ], "gene_names_uniprotkb": "Crot; Cot", "gene_names_refseq": "1200003H03Rik; Crot", "protein_names_uniprotkb": "Peroxisomal carnitine O-octanoyltransferase; 2.3.1.137; COT", "protein_names_refseq": "COT; peroxisomal carnitine O-octanoyltransferase isoform a; peroxisomal carnitine O-octanoyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:74114); (R-MMU-389887); (R-MMU-9033241)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "15492013;19224205;20173027;20484733;21952136;22872234;23576753;23806337;25428506;30084848;31599954;33356393;34428180;35820727;36058299;37507081;39927985", "class_list": "", "function": "Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate., [UniProtKB, PubMed]; CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction., [RefSeq, PubMed]; The Regulators of Peroxisomal Acyl-Carnitine Shuttle CROT and CRAT Promote Metastasis in Melanoma., [RefSeq, PubMed]; The crystal structures of carnitine octanoyltransferase alone and in complex with the substrate octanoylcarnitine, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q921I4", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.21", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0008458 carnitine O-octanoyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome", "go_biological_process": "GO:0006091 generation of precursor metabolites and energy;GO:0006631 fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0051791 medium-chain fatty acid metabolic process;GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9DC50-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35700-1", "uniprot_id": [ { "id": "PRDX1_MOUSE", "url": "https://www.uniprot.org/uniprot/P35700", "type": "external" } ], "mass": 22176.0, "length": 199, "protein_name": "Peroxiredoxin-1", "gene_name": "Prdx1", "organism": "Mouse", "refseq_name": "peroxiredoxin-1", "refseq_ac": [ { "id": "NP_035164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035164", "type": "external" } ], "gene_names_uniprotkb": "Prdx1; Msp23; Paga; Tdpx2", "gene_names_refseq": "MSP23; NkefA; OSF-3; OSF3; PAG; Paga; Prdx1; PrdxI; PrxI; TDX2; TPxA; Tdpx2; prx1", "protein_names_uniprotkb": "Peroxiredoxin-1; 1.11.1.24; Macrophage 23 kDa stress protein; OSF-3; Osteoblast-specific factor 3; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2; Thioredoxin-dependent peroxiredoxin 1", "protein_names_refseq": "Trx dependent peroxide reductase 2; macrophage 23 Kd stress protein; macrophage 23 kDa stress protein; macrophage 23kDa stress protein; macrophase stress protein 22kDa; macrophase stress protein 23 kd; osteoblast-specific factor 3; peroxiredoxin-1; proliferation-associated gene A; thioredoxin peroxidase 2; thioredoxin-dependent peroxide reductase 2; thioredoxin-dependent peroxiredoxin 1", "tax_id": 10090, "disease": "methylmalonic aciduria and homocystinuria type cblC (Disease Ontology:DOID:0050715)", "pathway": " (mmu:18477); (R-MMU-3000471); (R-MMU-3299685); (R-MMU-5628897); (R-MMU-9818027)", "pathway_count": 5, "publication_count": 30, "publication_id_list": "10.1101/2023.09.13.557529;10548725;19766572;20178744;21540332;21750661;21969592;22645316;23421996;23806337;24788674;25605945;26495903;26726832;28011936;28935714;30084848;31219806;33725478;34428180;36064721;36288343;37453647;37507081;38738971;39430237;39627609;39927985;8089076;8360158", "class_list": "", "function": "PRDX1 inhibits ferroptosis by binding to Cullin-3 as a molecular chaperone in colorectal cancer. Publication Status: Online-Only, [RefSeq, PubMed]; The interaction of PRDX1 with Cofilin promotes oral squamous cell carcinoma metastasis., [RefSeq, PubMed]; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (PubMed:19766572)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBV4;Q9CWI2", "ec_number_list": [ { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.98.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.98.2", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0020037 heme binding;GO:0051920 peroxiredoxin activity;GO:0008379 thioredoxin peroxidase activity;GO:0004601 peroxidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0008283 cell population proliferation;GO:0000302 response to reactive oxygen species;GO:0045454 cell redox homeostasis;GO:0019430 removal of superoxide radicals", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P35700-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHP6-1", "uniprot_id": [ { "id": "CDHR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHP6", "type": "external" } ], "mass": 94028.0, "length": 859, "protein_name": "Cadherin-related family member 1", "gene_name": "Cdhr1", "organism": "Mouse", "refseq_name": "cadherin-related family member 1 precursor", "refseq_ac": [ { "id": "NP_570948", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570948", "type": "external" } ], "gene_names_uniprotkb": "Cdhr1; Kiaa1775; Pcdh21; Prcad", "gene_names_refseq": "Cdhr1; Pcdh21; Prcad; mKIAA1775", "protein_names_uniprotkb": "Cadherin-related family member 1; Photoreceptor cadherin; Protocadherin-21; prCAD", "protein_names_refseq": "cadherin-related family member 1 precursor; photoreceptor cadherin; protocadherin-21", "tax_id": 10090, "disease": "cone-rod dystrophy 15 (Disease Ontology:DOID:0111021)", "pathway": " (mmu:170677)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;11738025;15284225;16106355;22872234;34203471", "class_list": "", "function": "Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells., [UniProtKB]; PrCAD ectodomain cleavage is an integral part of the outer segment assembly process, and outer segment assembly might be driven, at least in part, by the near irreversibility of proteolysis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9848, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFQ4;Q8CH99", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0045494 photoreceptor cell maintenance;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0035845 photoreceptor cell outer segment organization;GO:0008594 photoreceptor cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8VHP6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8B3-1", "uniprot_id": [ { "id": "CHM4B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8B3", "type": "external" } ], "mass": 24936.0, "length": 224, "protein_name": "Charged multivesicular body protein 4b", "gene_name": "Chmp4b", "organism": "Mouse", "refseq_name": "charged multivesicular body protein 4b", "refseq_ac": [ { "id": "NP_083638", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083638", "type": "external" } ], "gene_names_uniprotkb": "Chmp4b", "gene_names_refseq": "2010012F05Rik; Chmp4b; Snf7-2", "protein_names_uniprotkb": "Charged multivesicular body protein 4b; CHMP4b; Chromatin-modifying protein 4b", "protein_names_refseq": "charged multivesicular body protein 4b; chromatin modifying protein 4B; chromatin-modifying protein 4b", "tax_id": 10090, "disease": "cataract 31 multiple types (Disease Ontology:DOID:0110265)", "pathway": " (mmu:75608); (R-MMU-1632852); (R-MMU-5620971); (R-MMU-917729); (R-MMU-9668328)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "23806337;25428506;30084848;30779550;34428180;35690225;37487085;37931722", "class_list": "", "function": "CHMP4B and VSP4A reverse GSDMD-mediated pyroptosis by cell membrane remodeling in endometrial carcinoma., [RefSeq, PubMed]; HSP90beta prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53., [RefSeq, PubMed]; Long noncoding RNA Sh2d3c promotes manganese-induced neuronal apoptosis through the mmu-miR-675-5p/Chmp4b/Bax axis., [RefSeq, PubMed]; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan. Majority of the protein exists in a folded closed conformation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AVM1;Q3TXM7;Q91VM7;Q922P1", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005828 kinetochore microtubule;GO:0098978 glutamatergic synapse;GO:0000421 autophagosome membrane;GO:0005634 nucleus", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0036258 multivesicular body assembly;GO:0061763 multivesicular body-lysosome fusion;GO:0010506 regulation of autophagy;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D8B3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0G0-1", "uniprot_id": [ { "id": "GIPC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0G0", "type": "external" } ], "mass": 36129.0, "length": 333, "protein_name": "PDZ domain-containing protein GIPC1", "gene_name": "Gipc1", "organism": "Mouse", "refseq_name": "PDZ domain-containing protein GIPC1", "refseq_ac": [ { "id": "NP_061241", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061241", "type": "external" } ], "gene_names_uniprotkb": "Gipc1; Gipc; Rgs19ip1; Semcap1", "gene_names_refseq": "GIPC; Gipc1; Glut1CIP; Rgs19ip1; Semcap1; TIP-2; TaxIP2", "protein_names_uniprotkb": "PDZ domain-containing protein GIPC1; GAIP C-terminus-interacting protein; RGS-GAIP-interacting protein; RGS19-interacting protein 1; SEMCAP-1; SemaF cytoplasmic domain-associated protein 1; Synectin", "protein_names_refseq": "GAIP C-terminus-interacting protein; PDZ domain-containing protein GIPC1; RGS-GAIP interacting protein GIPC; RGS-GAIP-interacting protein; RGS19-interacting protein 1; SEMCAP-1; Tax interacting protein, clone 2; neurophilin1-IP; regulator of G-protein signaling 19 interacting protein 1; semaF cytoplasmic domain associated protein; semaF cytoplasmic domain-associated protein 1; synectin", "tax_id": 10090, "disease": "oculopharyngodistal myopathy 2 (Disease Ontology:DOID:0081298); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:67903); (R-MMU-190370); (R-MMU-190373); (R-MMU-9839389); (R-MMU-9839397)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "10318831;10911369;15527962;21750661;22872234;31219806;34203471;34428180;34705526;38186571;38458410;9770488", "class_list": "", "function": "GIPC1 promotes tumor growth and migration in gastric cancer via activating PDGFR/PI3K/AKT signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibits endothelial cell migration (in vitro). May be involved in G protein-linked signaling (By similarity)., [UniProtKB]; Overexpressing of the GIPC1 protects against pathological cardiac remodelling., [RefSeq, PubMed]; Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005096 GTPase activator activity;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0017022 myosin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005903 brush border;GO:0005938 cell cortex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0006605 protein targeting;GO:0007268 chemical synaptic transmission;GO:0048167 regulation of synaptic plasticity;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9Z0G0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z239-1", "uniprot_id": [ { "id": "PLM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z239", "type": "external" } ], "mass": 10323.0, "length": 92, "protein_name": "Phospholemman", "gene_name": "Fxyd1", "organism": "Mouse", "refseq_name": "phospholemman isoform a precursor", "refseq_ac": [ { "id": "NP_062376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062376", "type": "external" } ], "gene_names_uniprotkb": "Fxyd1; Plm", "gene_names_refseq": "0610012C17Rik; 1110006M24Rik; Fxyd1; Plm; Pml", "protein_names_uniprotkb": "Phospholemman; FXYD domain-containing ion transport regulator 1; Sodium/potassium-transporting ATPase subunit FXYD1", "protein_names_refseq": "phospholemman isoform a precursor; phospholemman; sodium/potassium-transporting ATPase subunit FXYD1", "tax_id": 10090, "disease": "congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:56188); (R-MMU-5578775); (R-MMU-936837)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "11410367;15563542;16002746;17242355;17283221;18065526;18630941;19187398;21183079;21454534;21750661;23532852;30084848;33934624;34428180;36288343;38133617", "class_list": "", "function": "A primary effect of phospholemman is to modulate the Na-K-ATPase and that its reduced activity initiates compensatory responses in heart hypertrophy, [RefSeq, PubMed]; Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:15563542, PubMed:18065526). Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated (By similarity). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (PubMed:21454534). Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone (PubMed:19187398)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; FXYD1 Is Protective Against Vascular Dysfunction., [RefSeq, PubMed]; PLM modulates the NKA function in a manner similar to the way phospholamban affects the related SR Ca-ATPase (inhibition of transport substrate affinity, that is relieved by phosphorylation)., [RefSeq, PubMed]; The FXYD1 protein plays a protective role against pulmonary hypertension and arterial remodeling via redox and inflammatory mechanisms., [RefSeq, PubMed]; This gene encodes a member of the FXYD family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity and act as an accessory protein of Na,K-ATPase. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding;GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0017022 myosin binding", "go_cellular_component": "GO:0014704 intercalated disc;GO:0016324 apical plasma membrane;GO:0005901 caveola;GO:0042383 sarcolemma;GO:0030315 T-tubule", "go_biological_process": "GO:0032892 positive regulation of organic acid transport;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0006813 potassium ion transport;GO:0006814 sodium ion transport;GO:0086004 regulation of cardiac muscle cell contraction", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9Z239-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35691-1", "uniprot_id": [ { "id": "PININ_MOUSE", "url": "https://www.uniprot.org/uniprot/O35691", "type": "external" } ], "mass": 82436.0, "length": 725, "protein_name": "Pinin", "gene_name": "Pnn", "organism": "Mouse", "refseq_name": "pinin", "refseq_ac": [ { "id": "NP_032917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032917", "type": "external" } ], "gene_names_uniprotkb": "Pnn", "gene_names_refseq": "D12Ertd512e; Pnn", "protein_names_uniprotkb": "Pinin", "protein_names_refseq": "pinin", "tax_id": 10090, "disease": "", "pathway": " (mmu:18949); (R-MMU-72163)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "16427813;17242355;19131326;19144319;21183079;21750661;23806337;24129315;25428506;25489234;31219806;34887587;39627609;9332356", "class_list": "", "function": "Pnn has an important role in alternative splicing of a specific subset of lncRNAs of the corneal epithelium. Publication Status: Online-Only, [RefSeq, PubMed]; Spatial and temporal expression profile of pinin during mouse development., [RefSeq, PubMed]; Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CD89;Q8CGU3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0071013 catalytic step 2 spliceosome;GO:0030057 desmosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0098609 cell-cell adhesion;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O35691-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHG7-1", "uniprot_id": [ { "id": "PK3CG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHG7", "type": "external" } ], "mass": 126400.0, "length": 1102, "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform", "gene_name": "Pik3cg", "organism": "Mouse", "refseq_name": "phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform", "refseq_ac": [ { "id": "NP_001139672", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139672", "type": "external" } ], "gene_names_uniprotkb": "Pik3cg; Pi3kg1", "gene_names_refseq": "5830428L06Rik; PI3Kgamma; Pik3cg; p110gamma; p120-PI3K", "protein_names_uniprotkb": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; 2.7.1.137; 2.7.1.153; 2.7.1.154; 2.7.11.1; PI3-kinase subunit gamma; PI3K-gamma; PI3Kgamma; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; Phosphoinositide-3-kinase catalytic gamma polypeptide; PtdIns-3-kinase subunit gamma; PtdIns-3-kinase subunit p110-gamma; Serine/threonine protein kinase PIK3CG; p110gamma; p120-PI3K", "protein_names_refseq": "PI3-kinase subunit gamma; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphoinositide-3-kinase, catalytic, gamma polypeptide; ptdIns-3-kinase subunit gamma; ptdIns-3-kinase subunit p110-gamma; serine/threonine protein kinase PIK3CG", "tax_id": 10090, "disease": "swine influenza (Disease Ontology:DOID:0050211); immunodeficiency 97 (Disease Ontology:DOID:0061067); autistic disorder (Disease Ontology:DOID:12849); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); liver cirrhosis (Disease Ontology:DOID:5082); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (mmu:30955); (R-MMU-114604); (R-MMU-1257604); (R-MMU-1660499); (R-MMU-389357); (R-MMU-392451); (R-MMU-6811558); (R-MMU-9027276); (R-MMU-9927354)", "pathway_count": 9, "publication_count": 17, "publication_id_list": "10669416;10669418;11054537;11416136;12297047;15294162;15318168;16116162;16127437;17673465;19297623;19906996;21474070;21750661;22728827;31554793;34428180", "class_list": "", "function": "Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:10669418, PubMed:11054537). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology (PubMed:10669416). Links G protein-coupled receptor activation to PIP3 production (PubMed:10669416). Involved in immune, inflammatory and allergic responses (PubMed:10669416, PubMed:10669418, PubMed:16127437, PubMed:31554793). Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge (PubMed:10669416). Controls motility of dendritic cells (PubMed:15318168). Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation (PubMed:16116162, PubMed:19297623). Participates in T-lymphocyte migration (PubMed:19297623). Regulates T-lymphocyte proliferation, activation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis (PubMed:17673465). Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism (PubMed:17673465). May have also a lipid kinase activity-dependent function in platelet aggregation (PubMed:17673465). Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility (PubMed:12297047). Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels (PubMed:12297047, PubMed:15294162, PubMed:21474070). Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation (PubMed:21474070). Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis (By similarity). May also have a scaffolding role in modulating cardiac contractility. Contribute to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis (By similarity). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway downstream of RASGRP4-mediated Ras-activation, to promote neutrophil functional responses (PubMed:22728827)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80V09", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" }, { "id": "2.7.1.151", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.151", "type": "external" }, { "id": "2.7.1.140", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.140", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046875 ephrin receptor binding;GO:0016303 1-phosphatidylinositol-3-kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005944 phosphatidylinositol 3-kinase complex, class IB", "go_biological_process": "GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0003376 sphingosine-1-phosphate receptor signaling pathway;GO:0001525 angiogenesis;GO:0006468 protein phosphorylation;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9JHG7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RPU2-1", "uniprot_id": [ { "id": "PLHD1_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RPU2", "type": "external" } ], "mass": 59097.0, "length": 505, "protein_name": "Pleckstrin homology domain-containing family D member 1", "gene_name": "Plekhd1", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family D member 1", "refseq_ac": [ { "id": "NP_001170974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170974", "type": "external" } ], "gene_names_uniprotkb": "Plekhd1", "gene_names_refseq": "3830431G21Rik; Plekhd1", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family D member 1; PH domain-containing family D member 1", "protein_names_refseq": "PH domain-containing family D member 1; pleckstrin homology domain-containing family D member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:217682)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "24129315;29187734", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B2RPU2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42337-1", "uniprot_id": [ { "id": "PK3CA_MOUSE", "url": "https://www.uniprot.org/uniprot/P42337", "type": "external" } ], "mass": 124412.0, "length": 1068, "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform", "gene_name": "Pik3ca", "organism": "Mouse", "refseq_name": "phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform", "refseq_ac": [ { "id": "NP_032865", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032865", "type": "external" } ], "gene_names_uniprotkb": "Pik3ca", "gene_names_refseq": "6330412C24Rik; Pik3ca; caPI3K; p110alpha; p110", "protein_names_uniprotkb": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; 2.7.1.137; 2.7.1.153; 2.7.11.1; PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; PtdIns-3-kinase subunit alpha; PtdIns-3-kinase subunit p110-alpha; Serine/threonine protein kinase PIK3CA; p110alpha", "protein_names_refseq": "PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphoinositide-3-kinase catalytic alpha polypeptide; ptdIns-3-kinase subunit alpha; ptdIns-3-kinase subunit p110-alpha; serine/threonine protein kinase PIK3CA", "tax_id": 10090, "disease": "estrogen-receptor positive breast cancer (Disease Ontology:DOID:0060075); cerebral cavernous malformation (Disease Ontology:DOID:0060669); colorectal carcinoma (Disease Ontology:DOID:0080199); CLOVES syndrome (Disease Ontology:DOID:0080351); Cowden syndrome 5 (Disease Ontology:DOID:0081001); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); epidermal nevus (Disease Ontology:DOID:0111162); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); rectal benign neoplasm (Disease Ontology:DOID:1984); colon adenocarcinoma (Disease Ontology:DOID:234); ovarian cancer (Disease Ontology:DOID:2394); cutaneous Paget's disease (Disease Ontology:DOID:3450); breast angiosarcoma (Disease Ontology:DOID:4511); esophageal cancer (Disease Ontology:DOID:5041); seborrheic keratosis (Disease Ontology:DOID:6498); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:18706); (R-MMU-109704); (R-MMU-112399); (R-MMU-114604); (R-MMU-1250342); (R-MMU-1257604); (R-MMU-1433557); (R-MMU-1660499); (R-MMU-180292); (R-MMU-186763); (R-MMU-1963642); (R-MMU-198203); (R-MMU-201556); (R-MMU-202424); (R-MMU-2029485); (R-MMU-210993); (R-MMU-2424491); (R-MMU-2730905); (R-MMU-389357); (R-MMU-416476); (R-MMU-4420097); (R-MMU-512988); (R-MMU-5654689); (R-MMU-5654695); (R-MMU-5654710); (R-MMU-5654720); (R-MMU-5673001); (R-MMU-6811558); (R-MMU-8851907); (R-MMU-8853659); (R-MMU-9009391); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9027276); (R-MMU-912526); (R-MMU-912631); (R-MMU-9607240); (R-MMU-9842663); (R-MMU-9927354)", "pathway_count": 39, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;15197263;16625210;16647110;17060635;17540175;18449193;19604150;21540297;21750661;25428506;27802388;30084848;30779550;34428180;8139567", "class_list": "", "function": "Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Plays a role in the positive regulation of phagocytosis and pinocytosis (PubMed:19604150)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 19, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0VGQ5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" }, { "id": "2.7.1.151", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.151", "type": "external" }, { "id": "2.7.1.140", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.140", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0030295 protein kinase activator activity;GO:0043560 insulin receptor substrate binding;GO:0016303 1-phosphatidylinositol-3-kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0014704 intercalated disc", "go_biological_process": "GO:0030835 negative regulation of actin filament depolymerization;GO:0043457 regulation of cellular respiration;GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0086003 cardiac muscle cell contraction;GO:0014870 response to muscle inactivity", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P42337-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0B9-1", "uniprot_id": [ { "id": "PLOD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0B9", "type": "external" } ], "mass": 84488.0, "length": 737, "protein_name": "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2", "gene_name": "Plod2", "organism": "Mouse", "refseq_name": "procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001136388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136388", "type": "external" } ], "gene_names_uniprotkb": "Plod2", "gene_names_refseq": "D530025C14Rik; LH2; Plod-2; Plod2", "protein_names_uniprotkb": "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; 1.14.11.4; LH2; Lysyl hydroxylase 2", "protein_names_refseq": "lysyl hydroxylase 2; procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform 1 precursor", "tax_id": 10090, "disease": "Bruck syndrome (Disease Ontology:DOID:0060231); hypothyroidism (Disease Ontology:DOID:1459); lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:26432); (R-MMU-1650814)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10429951;21750661;23806337;25428506;30084848;30899004;31219806;38454524;38472175;38696846;39088537", "class_list": "glycogene", "function": "Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links., [UniProtKB, UniProtKB]; Loss of the long form of Plod2 phenocopies contractures of Bruck syndrome-osteogenesis imperfecta., [RefSeq, PubMed]; PLOD2, a key factor for MRL MSC metabolism and chondroprotective properties. Publication Status: Online-Only, [RefSeq, PubMed]; Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes collagen cross-linking and ECM stiffening to induce liver fibrosis., [RefSeq, PubMed]; The HIF-1alpha/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 34, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "E9QM54;Q8VDT4", "ec_number_list": [ { "id": "1.14.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.4", "type": "external" }, { "id": "2.4.1.50", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.50", "type": "external" }, { "id": "2.4.1.66", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.66", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0008475 procollagen-lysine 5-dioxygenase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0031012 extracellular matrix", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0032964 collagen biosynthetic process;GO:0046947 hydroxylysine biosynthetic process;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9R0B9-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60487-1", "uniprot_id": [ { "id": "PLPP_MOUSE", "url": "https://www.uniprot.org/uniprot/P60487", "type": "external" } ], "mass": 31512.0, "length": 292, "protein_name": "Chronophin", "gene_name": "Pdxp", "organism": "Mouse", "refseq_name": "chronophin", "refseq_ac": [ { "id": "NP_064667", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064667", "type": "external" } ], "gene_names_uniprotkb": "Pdxp; Cin; Plpp; Plp", "gene_names_refseq": "1600027H05Rik; PLPP; Pdxp", "protein_names_uniprotkb": "Chronophin; 3.1.3.16; 3.1.3.74; PLP phosphatase; Pyridoxal 5'-phosphate phosphatase; Pyridoxal phosphate phosphatase", "protein_names_refseq": "PLP phosphatase; PLP-phosophatase; chronophilin; chronophin; pyridoxal 5'-phosphate phosphatase; pyridoxal phosphate phosphatase", "tax_id": 10090, "disease": "", "pathway": " (mmu:57028)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14522954;24338473;24338687;25783190;31320629;33300544;33414453", "class_list": "", "function": "Analysis of pyridoxal phosphatase cloning, expression and tissue distribution, [RefSeq, PubMed]; Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism (PubMed:24338473, PubMed:24338687, PubMed:25783190). Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; PLPP/CIN deletion inhibited NEDD4-2 ubiquitination, and diminished the responsiveness of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor by facilitating NEDD4-2-mediated ubiquitination of GluA1 subunit under physiological condition. PLPP/CIN overexpression reversed these effects. These PLPP/CIN-mediated processes were required for the increased seizure severity and its progression in response to kaini... Publication Status: Online-Only, [RefSeq, PubMed]; PLPP/CIN-mediated NF2-serine 10 dephosphorylation regulates F-actin stability and Mdm2 degradation in an activity-dependent manner. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0033883 pyridoxal phosphatase activity;GO:0000287 magnesium ion binding;GO:0019838 growth factor binding;GO:0042803 protein homodimerization activity;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005911 cell-cell junction;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0016311 dephosphorylation;GO:0032361 pyridoxal phosphate catabolic process;GO:0006470 protein dephosphorylation;GO:0007088 regulation of mitotic nuclear division;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P60487-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70181-1", "uniprot_id": [ { "id": "PI51B_MOUSE", "url": "https://www.uniprot.org/uniprot/P70181", "type": "external" } ], "mass": 60803.0, "length": 539, "protein_name": "Phosphatidylinositol 4-phosphate 5-kinase type-1 beta", "gene_name": "Pip5k1b", "organism": "Mouse", "refseq_name": "phosphatidylinositol 4-phosphate 5-kinase type-1 beta", "refseq_ac": [ { "id": "NP_032872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032872", "type": "external" } ], "gene_names_uniprotkb": "Pip5k1b", "gene_names_refseq": "PI4P5K-I[b]; PIP5K1-beta; PIP5KIbeta; Pip5k1b; Pipk5b; STM7", "protein_names_uniprotkb": "Phosphatidylinositol 4-phosphate 5-kinase type-1 beta; 2.7.1.68; 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase beta; PIP5KI-beta; PIP5KIalpha; PIP5KIbeta; Phosphatidylinositol 4-phosphate 5-kinase type I alpha; Phosphatidylinositol 4-phosphate 5-kinase type I beta; PtdIns(4)P-5-kinase 1 beta", "protein_names_refseq": "68 kDa type I phosphatidylinositol 4-phosphate 5-kinase beta; PIP5KI-beta; phosphatidylinositol 4-phosphate 5-kinase type I beta; phosphatidylinositol 4-phosphate 5-kinase type-1 beta; ptdIns(4)P-5-kinase 1 beta", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:18719); (R-MMU-1660499); (R-MMU-201688); (R-MMU-6811558)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10679324;10747863;11032811;15870270;18772378;21183079;22942276;27802388;30084848;30986855;36210013;8798574;9367159;9535851", "class_list": "", "function": "Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:22942276, PubMed:8798574, PubMed:9367159, PubMed:9535851). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). Mediates RAC1-dependent reorganization of actin filaments (PubMed:10679324). Contributes to the activation of phospholipase PLD2 (PubMed:11032811). Together with PIP5K1A, is required, after stimulation by G protein-coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (PubMed:18772378)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; PIP5k1beta controls bone homeostasis through modulating both osteoclast and osteoblast differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70335;Q8JZY6", "ec_number_list": [ { "id": "2.7.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.68", "type": "external" }, { "id": "2.7.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.149", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0001931 uropod", "go_biological_process": "GO:0006661 phosphatidylinositol biosynthetic process;GO:0046488 phosphatidylinositol metabolic process;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P70181-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62084-1", "uniprot_id": [ { "id": "PP14B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62084", "type": "external" } ], "mass": 15957.0, "length": 147, "protein_name": "Protein phosphatase 1 regulatory subunit 14B", "gene_name": "Ppp1r14b", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 14B", "refseq_ac": [ { "id": "NP_032915", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032915", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r14b; Png", "gene_names_refseq": "AOM172; PHI-1; PLCB3N; Png; Ppp1r14b", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 14B; PHI-1; Phosphatase holoenzyme inhibitor 1; Phospholipase C-beta-3 neighbouring gene protein", "protein_names_refseq": "phosphatase holoenzyme inhibitor 1; phospholipase C-beta-3 neighbouring gene protein; phospholipase c neighboring; protein phosphatase 1 regulatory subunit 14B", "tax_id": 10090, "disease": "", "pathway": " (mmu:18938)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10606530;12144526;15083373;21750661;22777184;8670283", "class_list": "", "function": "Inhibitor of PPP1CA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated., [UniProtKB, PubMed, PubMed]; Results indicate that phosphorylation of I-1 at Ser67 and Thr75 is associated with increased PP1 activity and depressed cardiomyocyte Ca(2+)-cycling, which manifests in geometrical alterations over the long term, [RefSeq, PubMed]; Whereas CPI-17 staining was diffuse, PHI-1 was concentrated along the cell membrane in distinct foci. The common tissue distribution but different cellular localization of PHI-1 and CPI-17 suggest distinctive physiological roles for these PP1 inhibitors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q640Q7", "ec_number_list": [], "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity;GO:0019888 protein phosphatase regulator activity;GO:0019212 phosphatase inhibitor activity;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q62084-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSI1-1", "uniprot_id": [ { "id": "PKHM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TSI1", "type": "external" } ], "mass": 118535.0, "length": 1074, "protein_name": "Pleckstrin homology domain-containing family M member 1", "gene_name": "Plekhm1", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family M member 1", "refseq_ac": [ { "id": "NP_898855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898855", "type": "external" } ], "gene_names_uniprotkb": "Plekhm1", "gene_names_refseq": "AP162; B2; D330036J23Rik; Plekhm1", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family M member 1; PH domain-containing family M member 1", "protein_names_refseq": "PH domain-containing family M member 1; pleckstrin homology domain-containing family M member 1", "tax_id": 10090, "disease": "autosomal recessive osteopetrosis 6 (Disease Ontology:DOID:0110945); osteopetrosis (Disease Ontology:DOID:13533)", "pathway": " (mmu:353047)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21183079;21750661;22073305;22872234;25498145;25905573;25992615;27777970;31219806;34428180", "class_list": "", "function": "Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (PubMed:25498145). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (PubMed:27777970). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7. May have a role in sialyl-lex-mediated transduction of apoptotic signals (By similarity). Involved in bone resorption (PubMed:27777970)., [UniProtKB, PubMed, PubMed, UniProtKB]; Identified PLEKHM1 as an endolysosomal adaptor platform that acts as a central hub to integrate endocytic and autophagic pathways at the lysosome, [RefSeq, PubMed]; Results indicate that LIS1 is a previously unrecognized regulator of osteoclast formation, microtubule organization, and lysosomal secretion by virtue of its ability to modulate dynein function and Plekhm1, [RefSeq, PubMed]; TRAFD1, in association with Plekhm1/Rab7-positive late endosomes-early lysosomes, has a previously unknown role in vesicle trafficking, acidification, and resorption in osteoclasts Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3L2;Q8CHU5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005764 lysosome;GO:0031902 late endosome membrane;GO:0044754 autolysosome", "go_biological_process": "GO:0015031 protein transport;GO:0045780 positive regulation of bone resorption;GO:0032418 lysosome localization;GO:1902774 late endosome to lysosome transport;GO:1900029 positive regulation of ruffle assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q7TSI1-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JMB7-1", "uniprot_id": [ { "id": "PIWL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JMB7", "type": "external" } ], "mass": 98574.0, "length": 862, "protein_name": "Piwi-like protein 1", "gene_name": "Piwil1", "organism": "Mouse", "refseq_name": "piwi-like protein 1", "refseq_ac": [ { "id": "NP_067286", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067286", "type": "external" } ], "gene_names_uniprotkb": "Piwil1; Miwi", "gene_names_refseq": "MIWI; Piwil1", "protein_names_uniprotkb": "Piwi-like protein 1; 3.1.26.-", "protein_names_refseq": "piwi-like homolog 1; piwi-like protein 1", "tax_id": 10090, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:57749)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "11578866;12062093;16751776;16766680;16787948;16787967;16938833;19020299;19377467;19465913;19584108;19918066;19926723;20534472;21237665;21750661;22121019;22900038;23328397;23523368;23714778;24757166;28254886;28552346;38491008", "class_list": "", "function": "Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (PubMed:11578866, PubMed:21237665, PubMed:22121019). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:11578866, PubMed:21237665, PubMed:22121019). Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (PubMed:11578866, PubMed:21237665, PubMed:22121019). Strongly prefers a uridine in the first position of their guide (g1U preference, also named 1U-bias) (PubMed:24757166). Not involved in the piRNA amplification loop, also named ping-pong amplification cycle (PubMed:22121019). Acts as an endoribonuclease that cleaves transposon messenger RNAs (PubMed:22121019). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (PubMed:16938833). Probable component of some RISC complex, which mediates RNA cleavage and translational silencing (PubMed:16938833). Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability (PubMed:16787948). Required to sequester RNF8 in the cytoplasm until late spermatogenesis; RNF8 being released upon ubiquitination and degradation of PIWIL1 (PubMed:28552346)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; PiRNA loading triggers MIWI translocation from the intermitochondrial cement to chromatoid body during mouse spermatogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1L324;A1L325;Q6NXX0", "ec_number_list": [ { "id": "2.1.1.386", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.386", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0016787 hydrolase activity;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0003727 single-stranded RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0097433 dense body;GO:0033391 chromatoid body", "go_biological_process": "GO:2000765 regulation of cytoplasmic translation;GO:0007283 spermatogenesis;GO:0007286 spermatid development;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0034587 piRNA processing", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q9JMB7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C437-1", "uniprot_id": [ { "id": "PEX5R_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C437", "type": "external" } ], "mass": 63135.0, "length": 567, "protein_name": "PEX5-related protein", "gene_name": "Pex5l", "organism": "Mouse", "refseq_name": "PEX5-related protein isoform 2", "refseq_ac": [ { "id": "NP_001156988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156988", "type": "external" } ], "gene_names_uniprotkb": "Pex5l; Pex2; Pex5r; Pxr2", "gene_names_refseq": "1700016J08Rik; PXR2; Pex2; Pex5l; TRIP8b; pex5Rp", "protein_names_uniprotkb": "PEX5-related protein; PEX2-related protein; PEX5-like protein; Peroxin-5-related protein; Pex5Rp; TRIP8b; Tetratricopeptide repeat-containing Rab8b-interacting protein", "protein_names_refseq": "PEX2-related protein; PEX5-like protein; PEX5-related protein isoform 2; PEX5-related protein; peroxin 2; peroxin-5-related protein; peroxisomal targeting signal 1 receptor-like; tetratricopeptide repeat-containing Rab8b-interacting protein", "tax_id": 10090, "disease": "peroxisomal biogenesis disorder (Disease Ontology:DOID:0080377); peroxisome biogenesis disorder 2A (Disease Ontology:DOID:0080477)", "pathway": " (mmu:58869)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15564593;16452087;17393522;21183079;21750661;22550182;30084848;31492750;33946275;36225302", "class_list": "", "function": "Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Both untreated and bile acid-fed PEX2(-/-) mice accumulated high levels of predominantly unconjugated bile acids in plasma because of altered expression of hepatocyte bile acid transporters., [RefSeq, PubMed]; Characterization of the HCN Interaction Partner TRIP8b/PEX5R in the Intracardiac Nervous System of TRIP8b-Deficient and Wild-Type Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of TRIP8b phosphorylation may affect HCN channel properties during epileptogenesis., [RefSeq, PubMed]; These data suggest a possible role for TRIP8b in regulating HCN channel density in the plasma membrane. [TRIP8b], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CA31;Q9DAA1;Q9JMB9", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0005052 peroxisome matrix targeting signal-1 binding;GO:0000268 peroxisome targeting sequence binding;GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity", "go_cellular_component": "GO:0051286 cell tip;GO:0005737 cytoplasm;GO:0005778 peroxisomal membrane;GO:0005829 cytosol;GO:0030425 dendrite", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0045055 regulated exocytosis;GO:0051461 positive regulation of corticotropin secretion;GO:0045185 maintenance of protein location;GO:0016560 protein import into peroxisome matrix, docking", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8C437-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UA06-1", "uniprot_id": [ { "id": "PCH2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UA06", "type": "external" } ], "mass": 48377.0, "length": 432, "protein_name": "Pachytene checkpoint protein 2 homolog", "gene_name": "Trip13", "organism": "Mouse", "refseq_name": "pachytene checkpoint protein 2 homolog isoform 1", "refseq_ac": [ { "id": "NP_081458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081458", "type": "external" } ], "gene_names_uniprotkb": "Trip13; Pch2", "gene_names_refseq": "2410002G23Rik; D13Ertd328e; Trip13", "protein_names_uniprotkb": "Pachytene checkpoint protein 2 homolog; TR-interacting protein 13; TRIP-13; Thyroid hormone receptor interactor 13; Thyroid receptor-interacting protein 13", "protein_names_refseq": "TR-interacting protein 13; TRIP-13; pachytene checkpoint protein 2 homolog isoform 1; pachytene checkpoint protein 2 homolog; thyroid receptor-interacting protein 13", "tax_id": 10090, "disease": "mosaic variegated aneuploidy syndrome 3 (Disease Ontology:DOID:0080689)", "pathway": " (mmu:69716)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17696610;19851446;20711356;21750661;31437213;31599954;34203471;34428180;38039923;39207914", "class_list": "", "function": "HORMAD1 and HORMAD2 are depleted from synapsed chromosome axes with the help of TRIP13., [RefSeq, PubMed]; Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (PubMed:17696610, PubMed:19851446, PubMed:20711356). Plays a role in mitotic spindle assembly checkpoint (SAC) activation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Results demonstrate that in mice, the primary meiotic function of TRIP13 is in recombination itself Erratum:[PLoS Genet. 2007 Sep 7;3(9):e168. Li, Xin [corrected to Li, Xin Chenglin]], [RefSeq, PubMed]; TRIP13 localizes to the central region of the synaptonemal complex and telomeres in spermatocytes. GeneRIF: Global loss of TRIP13 leads to meiotic arrest and TRIP13 is a dosage sensitive regulator of meiosis. Publication Status: Online-Only, [RefSeq, PubMed]; Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JNT8;Q05CL4;Q3UQG6;Q9CWW8", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0001673 male germ cell nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0051598 meiotic recombination checkpoint signaling;GO:0007144 female meiosis I;GO:0007283 spermatogenesis;GO:0007286 spermatid development;GO:0006302 double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3UA06-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BQ30-1", "uniprot_id": [ { "id": "PPR18_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BQ30", "type": "external" } ], "mass": 65630.0, "length": 594, "protein_name": "Phostensin", "gene_name": "Ppp1r18", "organism": "Mouse", "refseq_name": "phostensin isoform 1", "refseq_ac": [ { "id": "NP_001140182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001140182", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r18", "gene_names_refseq": "2310014H01Rik; Ppp1r18", "protein_names_uniprotkb": "Phostensin; Protein phosphatase 1 F-actin cytoskeleton-targeting subunit; Protein phosphatase 1 regulatory subunit 18", "protein_names_refseq": "phostensin isoform 1; phostensin; protein phosphatase 1 F-actin cytoskeleton-targeting subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:76448)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19144319;21183079;21750661;23806337;25153642;28135057;31219806;34428180;35766979;35820727", "class_list": "", "function": "May target protein phosphatase 1 to F-actin cytoskeleton., [UniProtKB]; Phostensin enables lymphocyte integrin activation and population of peripheral lymphoid organs., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B8JJ63;B8JJ64;Q3UDS6;Q8CEY9;Q8R3D8", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005856 cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BQ30-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKR6-1", "uniprot_id": [ { "id": "HYOU1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKR6", "type": "external" } ], "mass": 111181.0, "length": 999, "protein_name": "Hypoxia up-regulated protein 1", "gene_name": "Hyou1", "organism": "Mouse", "refseq_name": "hypoxia up-regulated protein 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_067370", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067370", "type": "external" } ], "gene_names_uniprotkb": "Hyou1; Grp170; Hsph4", "gene_names_refseq": "CBP-140; Cab140; Grp170; Hyou1; Orp150", "protein_names_uniprotkb": "Hypoxia up-regulated protein 1; 140 kDa Ca(2+)-binding protein; CBP-140; GRP-170", "protein_names_refseq": "140 kDa Ca(2+)-binding protein; 150-kDa oxygen regulated protein; 170 kDa glucose regulated protein GRP170; GRP-170; calcium binding protein 140; calcium binding protein, 140 kDa; hypoxia up-regulated protein 1 isoform 1 precursor; hypoxia up-regulated protein 1", "tax_id": 10090, "disease": "immunodeficiency 59 (Disease Ontology:DOID:0111974)", "pathway": " (mmu:12282)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;12475965;19349973;21750661;23806337;25605945;26495903;30059200;30084848;30710085;30899004;33300544;34428180;35104250;36724577;37507081;38446639;39627609;39950214;40885482;40997131;7641295", "class_list": "", "function": "FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells against inflammatory injury by regulating unfolded protein response., [RefSeq, PubMed]; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (PubMed:30710085). May play a role as a molecular chaperone and participate in protein folding (By similarity)., [UniProtKB, PubMed]; Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum function., [RefSeq, PubMed]; The molecular chaperone GRP170 protects against ER stress and acute kidney injury in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 24, "disease_count": 1, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAL1;Q3TZD0;Q3U1U2;Q64139;Q80X75", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005576 extracellular region;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0002931 response to ischemia;GO:0043066 negative regulation of apoptotic process;GO:0001666 response to hypoxia;GO:0071456 cellular response to hypoxia;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 5.8, "record_id": "Q9JKR6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100100010001.111.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70288-1", "uniprot_id": [ { "id": "HDAC2_MOUSE", "url": "https://www.uniprot.org/uniprot/P70288", "type": "external" } ], "mass": 55302.0, "length": 488, "protein_name": "Histone deacetylase 2", "gene_name": "Hdac2", "organism": "Mouse", "refseq_name": "histone deacetylase 2 isoform a", "refseq_ac": [ { "id": "NP_032255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032255", "type": "external" } ], "gene_names_uniprotkb": "Hdac2; Yy1bp", "gene_names_refseq": "D10Wsu179e; Hdac2; YAF1; Yy1bp; mRPD3", "protein_names_uniprotkb": "Histone deacetylase 2; 3.5.1.-; 3.5.1.98; HD2; Protein deacylase HDAC2; YY1 transcription factor-binding protein", "protein_names_refseq": "HD2; YY1 transcription factor-binding protein; histone deacetylase 2 isoform a; protein deacylase HDAC2", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); stroke (Disease Ontology:DOID:0051061); prostate carcinoma (Disease Ontology:DOID:10286); stomach cancer (Disease Ontology:DOID:10534); alcohol use disorder (Disease Ontology:DOID:1574); anxiety disorder (Disease Ontology:DOID:2030); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); temporal lobe epilepsy (Disease Ontology:DOID:3328); bronchitis (Disease Ontology:DOID:6132); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); Peyronie's disease (Disease Ontology:DOID:8616); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:15182); (R-MMU-3214815); (R-MMU-350054); (R-MMU-4551638); (R-MMU-6804758); (R-MMU-73762); (R-MMU-8943724); (R-MMU-9022692); (R-MMU-9701898); (R-MMU-9764725); (R-MMU-983231); (R-MMU-9937850); (R-MMU-9940951)", "pathway_count": 13, "publication_count": 42, "publication_id_list": "10.1101/2023.09.13.557529;10984530;11533236;11788710;12398767;15226430;16107708;16537907;17242355;17666527;17707228;18754010;19131326;19144319;20071335;20519513;20972425;21177534;21183079;21576649;21750661;22391310;23624624;24227653;24526703;24722245;25153642;25609639;27806305;28135057;28528544;30050113;30279482;30596969;30779550;32138755;34075040;34180153;34428180;35341968;8917507;9702189", "class_list": "", "function": "Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 19, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RRP3", "ec_number_list": [ { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.37", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.5.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.48", "type": "external" }, { "id": "3.5.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.62", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65", "type": "external" }, { "id": "1.14.99.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66", "type": "external" }, { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "1.21.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.21.99.4", "type": "external" } ], "go_molecular_function": "GO:0035851 Krueppel-associated box domain binding;GO:0003682 chromatin binding;GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0017053 transcription repressor complex;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:1902459 positive regulation of stem cell population maintenance;GO:0009913 epidermal cell differentiation;GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "P70288-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70349-1", "uniprot_id": [ { "id": "HINT1_MOUSE", "url": "https://www.uniprot.org/uniprot/P70349", "type": "external" } ], "mass": 13777.0, "length": 126, "protein_name": "Adenosine 5'-monophosphoramidase HINT1", "gene_name": "Hint1", "organism": "Mouse", "refseq_name": "adenosine 5'-monophosphoramidase HINT1", "refseq_ac": [ { "id": "NP_032274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032274", "type": "external" } ], "gene_names_uniprotkb": "Hint1; Hint; Pkci1; Pkci; Prkcnh1", "gene_names_refseq": "Hint1; Hint; Ipk1; PKCI-1; PRKCNH1", "protein_names_uniprotkb": "Adenosine 5'-monophosphoramidase HINT1; 3.4.22.-; 3.9.1.-; Desumoylating isopeptidase HINT1; Histidine triad nucleotide-binding protein 1; PKCI-1; Protein kinase C inhibitor 1; Protein kinase C-interacting protein 1", "protein_names_refseq": "PKC inhibitor/ interacting protein; adenosine 5'-monophosphoramidase HINT1; adenosine 5'-monophosphoramidase; desumoylating isopeptidase HINT1; protein kinase C inhibitor 1; protein kinase C-interacting protein 1", "tax_id": 10090, "disease": "Gamstorp-Wohlfart syndrome (Disease Ontology:DOID:0050526)", "pathway": " (mmu:15254); (R-MMU-9824594); (R-MMU-9825892); (R-MMU-9856649)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "12810953;21183079;21750661;23806337;25605945;31088288;34098726;34428180;34995725;35605301;36288343;37828378;39927985;9770345", "class_list": "", "function": "Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity). Hydrolyzes adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate) (By similarity). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester (By similarity). Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide (By similarity). In addition, functions as a scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1 (By similarity). Modulates p53/TP53 levels and p53/TP53-mediated apoptosis (PubMed:35605301). Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Also exhibits SUMO-specific isopeptidase activity, deconjugating SUMO1 from RANGAP1 and RGS17 (PubMed:31088288)., [UniProtKB, UniProtKB, PubMed, PubMed]; HINT1 (Histidine Triad Nucleotide-Binding Protein 1) Attenuates Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5) Expression., [RefSeq, PubMed]; HINT1 deficiency in aged mice reduces anxiety-like and depression-like behaviours and enhances cognitive performances., [RefSeq, PubMed]; USP40 deubiquitinates HINT1 and stabilizes p53 in podocyte damage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "3.9.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.-", "type": "external" }, { "id": "2.7.7.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.51", "type": "external" }, { "id": "3.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.2.1", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "6.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.6", "type": "external" } ], "go_molecular_function": "GO:0016929 deSUMOylase activity;GO:0016787 hydrolase activity;GO:0000166 nucleotide binding;GO:0043530 adenosine 5'-monophosphoramidase activity;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0006355 regulation of DNA-templated transcription;GO:0050850 positive regulation of calcium-mediated signaling;GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P70349-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60943-1", "uniprot_id": [ { "id": "I17RA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60943", "type": "external" } ], "mass": 97808.0, "length": 864, "protein_name": "Interleukin-17 receptor A", "gene_name": "Il17ra", "organism": "Mouse", "refseq_name": "interleukin-17 receptor A precursor", "refseq_ac": [ { "id": "NP_032385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032385", "type": "external" } ], "gene_names_uniprotkb": "Il17ra; Il17r", "gene_names_refseq": "Cdw217; Il17ra; Il17r; VDw217", "protein_names_uniprotkb": "Interleukin-17 receptor A; IL-17 receptor A; IL-17RA", "protein_names_refseq": "IL-17 receptor A; IL-17RA; interleukin-17 receptor A precursor", "tax_id": 10090, "disease": "immunodeficiency 51 (Disease Ontology:DOID:0111996)", "pathway": " (mmu:16172)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;17911633;18157131;19144317;20364087;20554964;21183079;21982598;21993848;21993849;25428506;26735852;27795421;27923703;28813677;33723527;39627609;8777726", "class_list": "", "function": "(Microbial infection) Receptor for SARS coronavirus-2/SARS-CoV-2 virus protein ORF8, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors through activating NF-kappa-B signaling pathway., [UniProtKB, PubMed]; Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:20554964, PubMed:27923703, PubMed:8777726). Receptor for IL17F (PubMed:17911633, PubMed:20554964). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (By similarity). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (By similarity). Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (By similarity). Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (PubMed:20364087, PubMed:21993848). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (PubMed:18157131). Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (PubMed:19144317). Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity (PubMed:27795421). Contributes to influenza A virus (H1N1) clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (PubMed:26735852). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21982598, PubMed:21993848, PubMed:21993849)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030368 interleukin-17 receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0032736 positive regulation of interleukin-13 production;GO:0032754 positive regulation of interleukin-5 production;GO:0032747 positive regulation of interleukin-23 production;GO:0006954 inflammatory response;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q60943-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12382-1", "uniprot_id": [ { "id": "PFKAL_MOUSE", "url": "https://www.uniprot.org/uniprot/P12382", "type": "external" } ], "mass": 85360.0, "length": 780, "protein_name": "ATP-dependent 6-phosphofructokinase, liver type", "gene_name": "Pfkl", "organism": "Mouse", "refseq_name": "ATP-dependent 6-phosphofructokinase, liver type isoform 1", "refseq_ac": [ { "id": "NP_032852", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032852", "type": "external" } ], "gene_names_uniprotkb": "Pfkl; Pfk-l; Pfkb", "gene_names_refseq": "ATP-PFK; PFK-B; PFK-L; Pfkl", "protein_names_uniprotkb": "ATP-dependent 6-phosphofructokinase, liver type; 2.7.1.11; 6-phosphofructokinase type B; ATP-PFK; PFK-B; PFK-L; Phosphofructo-1-kinase isozyme B; Phosphohexokinase", "protein_names_refseq": "6-phosphofructokinase type B; 6-phosphofructokinase, liver type; ATP-dependent 6-phosphofructokinase, liver type isoform 1; ATP-dependent 6-phosphofructokinase, liver type; phosphofructo-1-kinase isozyme B; phosphofructokinase 1; phosphohexokinase", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); glycogen storage disease (Disease Ontology:DOID:2747)", "pathway": " (mmu:18641); (R-MMU-6798695); (R-MMU-70171)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;18034455;19131326;21750661;22872234;25605945;26194095;2969893;31219806;33300544;34203471;34428180;35820727;36288343;37116593;37507081", "class_list": "glycogene", "function": "Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (PubMed:26194095)., [UniProtKB, HAMAP, PubMed]; Caveolin-1 depletion attenuates hepatic fibrosis via promoting SQSTM1-mediated PFKL degradation in HSCs., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 28, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8VDX7", "ec_number_list": [ { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0070095 fructose-6-phosphate binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0005945 6-phosphofructokinase complex", "go_biological_process": "GO:0046676 negative regulation of insulin secretion;GO:0009749 response to glucose;GO:0006096 glycolytic process;GO:0030388 fructose 1,6-bisphosphate metabolic process;GO:0061621 canonical glycolysis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P12382-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000001001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJT9-1", "uniprot_id": [ { "id": "PHAX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJT9", "type": "external" } ], "mass": 43247.0, "length": 385, "protein_name": "Phosphorylated adapter RNA export protein", "gene_name": "Phax", "organism": "Mouse", "refseq_name": "phosphorylated adapter RNA export protein isoform 2", "refseq_ac": [ { "id": "NP_001156461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156461", "type": "external" } ], "gene_names_uniprotkb": "Phax; Rnuxa", "gene_names_refseq": "2810055C14Rik; 4933427L19Rik; D18Ertd65e; Phax; Rnuxa; p55", "protein_names_uniprotkb": "Phosphorylated adapter RNA export protein; RNA U small nuclear RNA export adapter protein", "protein_names_refseq": "RNA U small nuclear RNA export adapter protein; RNA U, small nuclear RNA export adaptor; phosphorylated adapter RNA export protein isoform 2; phosphorylated adapter RNA export protein; phosphorylation regulated", "tax_id": 10090, "disease": "", "pathway": " (mmu:56698); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10786834;11333016;15345747;17242355;21750661", "class_list": "", "function": "A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner. Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA (By similarity)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BSR8", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0015643 toxic substance binding;GO:0140262 mRNA cap binding complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0043025 neuronal cell body;GO:0015030 Cajal body", "go_biological_process": "GO:0015031 protein transport;GO:0006408 snRNA export from nucleus;GO:0043489 RNA stabilization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JJT9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88492-1", "uniprot_id": [ { "id": "PLIN4_MOUSE", "url": "https://www.uniprot.org/uniprot/O88492", "type": "external" } ], "mass": 139415.0, "length": 1403, "protein_name": "Perilipin-4", "gene_name": "Plin4", "organism": "Mouse", "refseq_name": "perilipin-4 isoform 2", "refseq_ac": [ { "id": "NP_065593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065593", "type": "external" } ], "gene_names_uniprotkb": "Plin4; Kiaa1881", "gene_names_refseq": "Plin4; S3-12; mKIAA1881", "protein_names_uniprotkb": "Perilipin-4; Adipocyte protein S3-12", "protein_names_refseq": "adipocyte protein S3-12; perilipin-4 isoform 2; plasma membrane associated protein, S3-12", "tax_id": 10090, "disease": "", "pathway": " (mmu:57435)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12840023;15111493;15731108;21183079;21750661;32848054;34428180;36288343;37507081;38677512;39173539;39927985;40021952;9624692", "class_list": "", "function": "Adipocyte protein S3-12 coats nascent lipid droplets., [RefSeq, PubMed]; Direct regulation of perilipin and S3-12 by PPAR-gamma may to be important mediator of prolonged treatment with PPAR-gamma activators: insulin sensitization, fatty acid trapping in adipose tissue, reduced basal adipose lipolysis, and weight gain., [RefSeq, PubMed]; May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Plin4 exacerbates cadmium-decreased testosterone level via inducing ferroptosis in testicular Leydig cells., [RefSeq, PubMed]; Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation., [RefSeq, PubMed]; The non-lipid droplet pools of S3-12, adipophilin, and TIP47 constitute a ready reservoir of coat proteins to permit rapid packaging of newly synthesized triacylglycerol and to maximize energy storage during nutrient excess, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "E9QN72;Q69Z80;Q8BNV5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "O88492-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47857-1", "uniprot_id": [ { "id": "PFKAM_MOUSE", "url": "https://www.uniprot.org/uniprot/P47857", "type": "external" } ], "mass": 85269.0, "length": 780, "protein_name": "ATP-dependent 6-phosphofructokinase, muscle type", "gene_name": "Pfkm", "organism": "Mouse", "refseq_name": "ATP-dependent 6-phosphofructokinase, muscle type", "refseq_ac": [ { "id": "NP_001156959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156959", "type": "external" } ], "gene_names_uniprotkb": "Pfkm; Pfk-m; Pfka", "gene_names_refseq": "ATP-PFK; PFK-A; PFK-M; Pfk-4; Pfk4; Pfka; Pfkm; Pfkx", "protein_names_uniprotkb": "ATP-dependent 6-phosphofructokinase, muscle type; 2.7.1.11; 6-phosphofructokinase type A; ATP-PFK; PFK-A; PFK-M; Phosphofructo-1-kinase isozyme A; Phosphohexokinase", "protein_names_refseq": "6-phosphofructokinase type A; 6-phosphofructokinase, muscle type; ATP-dependent 6-phosphofructokinase, muscle type; phosphofructo-1-kinase isozyme A; phosphofructokinase 1; phosphofructokinase 4; phosphofructokinase M variant 3/4; phosphofructokinase, polypeptide X; phosphofructokinase-1 A isozyme; phosphofructokinase-M (connecting peptide); phosphohexokinase", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); glycogen storage disease VII (Disease Ontology:DOID:11721); glycogen storage disease (Disease Ontology:DOID:2747)", "pathway": " (mmu:18642); (R-MMU-70171)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11137296;19889946;21183079;21750661;22872234;33300544;34203471;34428180;37507081;39927985;7980403", "class_list": "glycogene", "function": "Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis., [UniProtKB, PubMed, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 35, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "C8CMN5;C8CMN6;C8CMN7;O35513;Q543L1;Q9JK94", "ec_number_list": [ { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" } ], "go_molecular_function": "GO:0070095 fructose-6-phosphate binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0016208 AMP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016020 membrane;GO:0016324 apical plasma membrane;GO:0097228 sperm principal piece", "go_biological_process": "GO:0032024 positive regulation of insulin secretion;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0046716 muscle cell cellular homeostasis;GO:0042593 glucose homeostasis;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P47857-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000001001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P67778-1", "uniprot_id": [ { "id": "PHB1_MOUSE", "url": "https://www.uniprot.org/uniprot/P67778", "type": "external" } ], "mass": 29820.0, "length": 272, "protein_name": "Prohibitin 1", "gene_name": "Phb1", "organism": "Mouse", "refseq_name": "prohibitin 1", "refseq_ac": [ { "id": "NP_032857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032857", "type": "external" } ], "gene_names_uniprotkb": "Phb1; Phb", "gene_names_refseq": "Bap32; Phb1; Phb", "protein_names_uniprotkb": "Prohibitin 1; B-cell receptor-associated protein 32; BAP 32", "protein_names_refseq": "B-cell receptor-associated protein 32; prohibitin 1; prohibitin", "tax_id": 10090, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); transitional cell carcinoma (Disease Ontology:DOID:2671); sporadic breast cancer (Disease Ontology:DOID:8029); prostate carcinoma in situ (Disease Ontology:DOID:8634); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (mmu:18673); (R-MMU-5673000); (R-MMU-8949664)", "pathway_count": 3, "publication_count": 29, "publication_id_list": "10.1101/2023.09.13.557529;11302691;16075062;18034455;19372376;20887712;20959514;21750661;22410782;23241883;23576753;23806337;24856930;24947361;26495903;29324904;31219806;31599954;31819158;32859869;33300544;34203471;34428180;35219912;37453647;37507081;38176624;39627609;8070406", "class_list": "", "function": "(Microbial infection) In neuronal cells, cell surface-expressed PHB1 is involved in human enterovirus 71/EV-71 entry into neuronal cells specifically, while membrane-bound mitochondrial PHB1 associates with the virus replication complex and facilitates viral replication (PubMed:29324904). May serve as a receptor for EV71 (PubMed:29324904)., [UniProtKB, PubMed]; In the mitochondria, together with PHB2, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (PubMed:24856930). Regulates mitochondrial respiration activity playing a role in cellular aging (PubMed:11302691). The prohibitin complex plays a role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:31819158). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses (By similarity). Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates (PubMed:23241883). Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (PubMed:23241883)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~58%., [RefSeq, PubMed]; Novel effects of prohibitin 1 expression level on cholesterol and lipid homeostasis., [RefSeq, PubMed]; Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:23241883, PubMed:24856930, PubMed:29324904). Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner (PubMed:24947361). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P24142;Q3UB75;Q5SQG4", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0046982 protein heterodimerization activity;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding;GO:0001851 complement component C3b binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0032740 positive regulation of interleukin-17 production;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P67778-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08481-1", "uniprot_id": [ { "id": "PECA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08481", "type": "external" } ], "mass": 81263.0, "length": 727, "protein_name": "Platelet endothelial cell adhesion molecule", "gene_name": "Pecam1", "organism": "Mouse", "refseq_name": "platelet endothelial cell adhesion molecule isoform 2 precursor", "refseq_ac": [ { "id": "NP_001027550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027550", "type": "external" } ], "gene_names_uniprotkb": "Pecam1; Pecam-1; Pecam", "gene_names_refseq": "Cd31; PECAM-1; Pecam1; Pecam", "protein_names_uniprotkb": "Platelet endothelial cell adhesion molecule; PECAM-1", "protein_names_refseq": "platelet endothelial cell adhesion molecule isoform 2 precursor; platelet endothelial cell adhesion molecule", "tax_id": 10090, "disease": "pterygium (Disease Ontology:DOID:0002116); chronic venous insufficiency (Disease Ontology:DOID:0050853); sickle cell anemia (Disease Ontology:DOID:10923); polycystic ovary syndrome (Disease Ontology:DOID:11612); common variable immunodeficiency (Disease Ontology:DOID:12177); autistic disorder (Disease Ontology:DOID:12849); eosinophilic esophagitis (Disease Ontology:DOID:13922); atherosclerosis (Disease Ontology:DOID:1936); ovarian cancer (Disease Ontology:DOID:2394); orchitis (Disease Ontology:DOID:2518); severe acute respiratory syndrome (Disease Ontology:DOID:2945); neurilemmoma (Disease Ontology:DOID:3192); coronary artery disease (Disease Ontology:DOID:3393); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); coronary stenosis (Disease Ontology:DOID:4248); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); neuroblastoma (Disease Ontology:DOID:769); varicose veins (Disease Ontology:DOID:799); osteoarthritis (Disease Ontology:DOID:8398); polymyalgia rheumatica (Disease Ontology:DOID:853); chronic myeloid leukemia (Disease Ontology:DOID:8552); myeloid leukemia (Disease Ontology:DOID:8692); bacterial pneumonia (Disease Ontology:DOID:874); psoriatic arthritis (Disease Ontology:DOID:9008); babesiosis (Disease Ontology:DOID:9643)", "pathway": " (mmu:18613); (R-MMU-114608); (R-MMU-202733); (R-MMU-210990); (R-MMU-216083); (R-MMU-432142); (R-MMU-6798695)", "pathway_count": 7, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;1415479;16731527;17947660;18388311;19048083;19349973;21750661;25428506;26495903;26740625;28011936;28179430;39627609;8516303", "class_list": "glycogene", "function": "Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (By similarity). Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (By similarity). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (By similarity). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (By similarity). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (By similarity). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (By similarity). Modulates bradykinin receptor BDKRB2 activation (By similarity). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (By similarity). Induces susceptibility to atherosclerosis (PubMed:19048083)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 64, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 28, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "B1ARB1;B1ARB2;Q3TES6;Q922E0", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042803 protein homodimerization activity;GO:0019903 protein phosphatase binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0090673 endothelial cell-matrix adhesion;GO:0061028 establishment of endothelial barrier;GO:0001525 angiogenesis;GO:0006955 immune response;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q08481-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.100.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q149B8-1", "uniprot_id": [ { "id": "PERM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q149B8", "type": "external" } ], "mass": 85157.0, "length": 807, "protein_name": "PGC-1 and ERR-induced regulator in muscle protein 1", "gene_name": "Perm1", "organism": "Mouse", "refseq_name": "PGC-1 and ERR-induced regulator in muscle protein 1", "refseq_ac": [ { "id": "NP_766005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766005", "type": "external" } ], "gene_names_uniprotkb": "Perm1", "gene_names_refseq": "2310042D19Rik; Perm1", "protein_names_uniprotkb": "PGC-1 and ERR-induced regulator in muscle protein 1; PPARGC1 and ESRR-induced regulator in muscle 1; Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1", "protein_names_refseq": "PGC-1 and ERR-induced regulator in muscle 1; PGC-1 and ERR-induced regulator in muscle protein 1; PPARGC1 and ESRR-induced regulator in muscle 1; peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74183)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "21183079;23836911;24129315;30862473;32574189;32595605;33546195;34029594;34385433;36028747;36288343;39581161", "class_list": "", "function": "A role for Perm1 acting downstream of PGC-1alpha and ERRs to regulate muscle-specific pathways important for energy metabolism and contractile function., [RefSeq, PubMed]; Citrus hassaku Extract Powder Increases Mitochondrial Content and Oxidative Muscle Fibers by Upregulation of PGC-1alpha in Skeletal Muscle. Publication Status: Online-Only, [RefSeq, PubMed]; ESRRG and PERM1 Govern Mitochondrial Conversion in Brite/Beige Adipocyte Formation. Publication Status: Online-Only, [RefSeq, PubMed]; PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B. Publication Status: Online-Only, [RefSeq, PubMed]; PERM1 regulates genes involved in fatty acid metabolism in the heart by interacting with PPARalpha and PGC-1alpha. Publication Status: Online-Only, [RefSeq, PubMed]; Perm1 promotes cardiomyocyte mitochondrial biogenesis and protects against hypoxia/reoxygenation-induced damage in mice. Erratum:[J Biol Chem. 2021 Sep;297(3):101121. doi: 10.1016/j.jbc.2021.101121. PMID: 34464737], [RefSeq, PubMed]; Perm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4., [UniProtKB, PubMed]; These findings identify Perm1 as a muscle-specific regulator of exercise-induced signaling and Perm1 levels as tuners of the skeletal muscle response to exercise., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QP35;Q8BS19;Q8CB71", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0014850 response to muscle activity", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q149B8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BVZ1-1", "uniprot_id": [ { "id": "PLIN5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BVZ1", "type": "external" } ], "mass": 50474.0, "length": 463, "protein_name": "Perilipin-5", "gene_name": "Plin5", "organism": "Mouse", "refseq_name": "perilipin-5", "refseq_ac": [ { "id": "NP_001070816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070816", "type": "external" } ], "gene_names_uniprotkb": "Plin5; Lsdp5; Mldp; Oxpat; Pat1", "gene_names_refseq": "2310076L09Rik; Lsdp5; MLDP; PAT-1; Plin5", "protein_names_uniprotkb": "Perilipin-5; Lipid droplet-associated protein PAT-1; Lipid storage droplet protein 5; Myocardial LD protein", "protein_names_refseq": "lipid droplet associated protein; lipid droplet-associated protein PAT-1; lipid storage droplet protein 5; myocardial LD protein; perilipin-5", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:66968)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "16571721;17130488;17234449;17242355;19064991;19717842;21148142;21183079;21393244;21885430;22532565;22675471;23345411;23423172;23606724;28919478;31166588;33334871;36288343;37667357;37933091;38749744;39469452", "class_list": "", "function": "Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; MLDP is a novel PAT family protein localized to lipid droplets and enriched in the heart, and regulated by peroxisome proliferator-activated receptor alpha, [RefSeq, PubMed]; PLIN5 Suppresses Lipotoxicity and Ferroptosis in Cardiomyocyte via Modulating PIR/NF-kappaB Axis., [RefSeq, PubMed]; Perilipin 5 deficiency aggravates cardiac hypertrophy by stimulating lactate production in leptin-deficient mice. Publication Status: Online-Only, [RefSeq, PubMed]; Perilipin 5 protects the mitochondrial oxidative functions and improves the alcoholic liver injury in mice., [RefSeq, PubMed]; The influence of perilipin 5 deficiency on gut microbiome profiles in murine metabolic dysfunction-associated fatty liver disease (MAFLD) and MAFLD-hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; We have characterized a novel PAT protein, lipid storage droplet protein 5 (LSDP5) of 463 residues.The LSDP5 gene is primarily transcribed in cells that actively oxidize fatty acids, such as heart, red muscle and liver., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q78IK8", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0035473 lipase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0032000 positive regulation of fatty acid beta-oxidation;GO:0010884 positive regulation of lipid storage;GO:0031999 negative regulation of fatty acid beta-oxidation;GO:0050995 negative regulation of lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q8BVZ1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BYB9-1", "uniprot_id": [ { "id": "PGLT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BYB9", "type": "external" } ], "mass": 46379.0, "length": 392, "protein_name": "Protein O-glucosyltransferase 1", "gene_name": "Poglut1", "organism": "Mouse", "refseq_name": "protein O-glucosyltransferase 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_759012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_759012", "type": "external" } ], "gene_names_uniprotkb": "Poglut1; Clp46; Ktelc1", "gene_names_refseq": "9630046K23Rik; Clp46; Ktelc1; Poglut1; Rumi; wsnp", "protein_names_uniprotkb": "Protein O-glucosyltransferase 1; 2.4.1.376; 2.4.2.63; CAP10-like 46 kDa protein; KTEL motif-containing protein 1; O-glucosyltransferase Rumi homolog; Protein O-xylosyltransferase POGLUT1; Rumi; Wing-shaped neural plate protein; Wsnp", "protein_names_refseq": "CAP10-like 46 kDa protein; KTEL (Lys-Tyr-Glu-Leu) containing 1; KTEL motif-containing protein 1; O-glucosyltransferase Rumi homolog; protein O-glucosyltransferase 1 isoform 1 precursor; protein O-xylosyltransferase POGLUT1; wing-shaped neural plate protein", "tax_id": 10090, "disease": "Dowling-Degos disease (Disease Ontology:DOID:0060256); autosomal recessive limb-girdle muscular dystrophy type 2Z (Disease Ontology:DOID:0080762); autosomal recessive limb-girdle muscular dystrophy (Disease Ontology:DOID:0110274)", "pathway": " (mmu:224143)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;21490058;21949356;26235536;26496195;30899004;31219806;34203471;34428180;35820727;36210013;37021797;37828378;40997131", "class_list": "glycogene;glycosyltransferase", "function": "ASO silencing of a glycosyltransferase, Poglut1 , improves the liver phenotypes in mouse models of Alagille syndrome., [RefSeq, PubMed]; Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C (PubMed:21949356, PubMed:26496195). Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 (PubMed:21949356, PubMed:26496195). Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (By similarity). Notch glucosylation does not affect Notch ligand binding (By similarity). Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (PubMed:26496195)., [UniProtKB, UniProtKB, PubMed, PubMed]; Removing one copy of Rumi suppresses the Jag1(+/-) bile duct phenotype, indicating that Rumi opposes JAG1 function in the liver, [RefSeq, PubMed]; Rumi(-/-) embryos die before embryonic day 9.5 with posterior axis truncation and severe defects in neural tube development, somitogenesis, cardiogenesis and vascular remodeling., [RefSeq, PubMed]; The data demonstrate that CRUMBS2 is the target of POGLUT1 for the gastrulation epithelial-to-mesenchymal transitions (EMT) and that all activity of CRUMBS2 depends on modification by POGLUT1 Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein that can catalyze transfer of either UDP-glucose or UDP-xylose to epidermal growth factor (EGF) repeats, such as those found in Notch. Loss of this gene product results in embryonic lethality. Embryos have neural plate defects, heart defects, and truncations of their posterior axis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0H7", "ec_number_list": [ { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.376", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.376", "type": "external" }, { "id": "2.4.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.63", "type": "external" } ], "go_molecular_function": "GO:0046527 glucosyltransferase activity;GO:0035252 UDP-xylosyltransferase activity;GO:0035251 UDP-glucosyltransferase activity;GO:0140561 EGF-domain serine glucosyltransferase activity;GO:0140562 EGF-domain serine xylosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0012505 endomembrane system", "go_biological_process": "GO:0010470 regulation of gastrulation;GO:0072359 circulatory system development;GO:0006493 protein O-linked glycosylation;GO:0045747 positive regulation of Notch signaling pathway;GO:0001756 somitogenesis", "synthesized_glycan_count": 6710, "hit_score": 2.8, "record_id": "Q8BYB9-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000000.100.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHP8-1", "uniprot_id": [ { "id": "PGP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHP8", "type": "external" } ], "mass": 34541.0, "length": 321, "protein_name": "Phosphoglycolate phosphatase", "gene_name": "Pgp", "organism": "Mouse", "refseq_name": "glycerol-3-phosphate phosphatase", "refseq_ac": [ { "id": "NP_080230", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080230", "type": "external" } ], "gene_names_uniprotkb": "Pgp", "gene_names_refseq": "1700012G19Rik; AUM; G3PP; Pgp", "protein_names_uniprotkb": "Phosphoglycolate phosphatase; 3.1.3.18; 3.1.3.21; 3.1.3.48; AUM; Aspartate-based ubiquitous Mg(2+)-dependent phosphatase; G3PP; Glycerol-3-phosphate phosphatase", "protein_names_refseq": "PGPase; aspartate-based ubiquitous Mg(2+)-dependent phosphatase; glycerol-3-phosphate phosphatase", "tax_id": 10090, "disease": "", "pathway": " (mmu:67078); (R-MMU-1483206)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;24338473;26755581;27179418;27294321;27731369;33300544;36288343;36369173;37507081;37704894;39927985", "class_list": "", "function": "A previously known phosphoglycolate phosphatase (PGP) with an uncertain function acts as a specific glycerol-3-phosphate phosphatase and plays a role in the glucose and lipid metabolism and signaling, and the response to metabolic stress., [RefSeq, PubMed]; Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities., [RefSeq, PubMed]; Functional Evaluation of P-gp and Bcrp at the Murine Blood-Cerebrospinal Fluid Barrier., [RefSeq, PubMed]; Our findings establish that PGP, an aspartate-dependent HAD phosphatase, is transiently inactivated by reversible oxidation in cells, [RefSeq, PubMed]; Phosphatase with activity against multiple substrates (PubMed:27294321). Acts as a metabolite repair enzyme which eliminates toxic glycolytic side products (PubMed:27294321). Dephosphorylates 2-phosphoglycolate which is generated during the repair of oxidative DNA lesions (PubMed:27179418, PubMed:27294321, PubMed:27731369). This controls triosephosphate isomerase activity, glycerolipid partitioning and cell proliferation in the embryo and is required for embryonic development (PubMed:27731369). Dephosphorylates 4-phosphoerythronate, a side product which is produced by GAPDH and which inhibits 6-phosphogluconate dehydrogenase (PubMed:27294321). Dephosphorylation of 4-phosphoerythronate prevents the accumulation of high 4-phosphoerythronate levels which would otherwise inhibit the pentose phosphate pathway (By similarity). Dephosphorylates 2-phospho-L-lactate which is a product of a pyruvate kinase side reaction (PubMed:27294321). This prevents the inhibition of fructose-2,6-bisphosphate production and allows glycolysis to occur (By similarity). Has glycerol-3-phosphate phosphatase activity, hydrolyzing glycerol-3-phosphate into glycerol and thereby regulating the cellular levels of glycerol-3-phosphate, a metabolic intermediate of glucose, lipid and energy metabolism (PubMed:26755581). Has been shown to have tyrosine-protein phosphatase activity although the physiological relevance is unclear (PubMed:26755581). In vitro, has phosphatase activity toward ADP, ATP, GDP and GTP (PubMed:24338473)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 17, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0008967 phosphoglycolate phosphatase activity;GO:0043262 ADP phosphatase activity;GO:0000121 sn-glycerol 1-phosphatase activity;GO:0043136 sn-glycerol 3-phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0006114 glycerol biosynthetic process;GO:0045721 negative regulation of gluconeogenesis;GO:0110052 toxic metabolite repair", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8CHP8-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MZ7-1", "uniprot_id": [ { "id": "PECR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MZ7", "type": "external" } ], "mass": 32410.0, "length": 303, "protein_name": "Peroxisomal trans-2-enoyl-CoA reductase", "gene_name": "Pecr", "organism": "Mouse", "refseq_name": "peroxisomal trans-2-enoyl-CoA reductase isoform 1", "refseq_ac": [ { "id": "NP_076012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076012", "type": "external" } ], "gene_names_uniprotkb": "Pecr", "gene_names_refseq": "2400003B18Rik; Pecr; TERP", "protein_names_uniprotkb": "Peroxisomal trans-2-enoyl-CoA reductase; 1.3.1.38; TERP", "protein_names_refseq": "perosisomal 2-enoyl-CoA reductase; peroxisomal trans-2-enoyl-CoA reductase isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:111175); (R-MMU-389599); (R-MMU-9033241)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10811639;11669066;21750661;23576753;23806337;25428506;30084848;31219806;34428180;36724637;37453647", "class_list": "", "function": "A paper describing the functions of peroxisomal trans 2-enoyl CoA reductase, [RefSeq, PubMed]; Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Peroxisomal trans-2-enoyl-CoA inhibits proliferation, migration and invasion of hepatocellular carcinoma cells. Erratum:[Acta Histochem. 2024 Jan;126(1):152130. doi: 10.1016/j.acthis.2023.152130. PMID: 38177047], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CX01;Q9JIF4", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity;GO:0005102 signaling receptor binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0043231 intracellular membrane-bounded organelle", "go_biological_process": "GO:0033306 phytol metabolic process;GO:0030497 fatty acid elongation;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q99MZ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D4H9-2", "uniprot_id": [ { "id": "PHF14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D4H9", "type": "external" } ], "mass": 105947.0, "length": 941, "protein_name": "PHD finger protein 14", "gene_name": "Phf14", "organism": "Mouse", "refseq_name": "PHD finger protein 14 isoform 1", "refseq_ac": [ { "id": "NP_001161854", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161854", "type": "external" } ], "gene_names_uniprotkb": "Phf14", "gene_names_refseq": "1110001C23Rik; 4932409F11Rik; 5730446A07Rik; Phf14; mKIAA0783", "protein_names_uniprotkb": "PHD finger protein 14", "protein_names_refseq": "PHD finger protein 14 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:75725)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17242355;17525332;18299400;21183079;21952136;22730381;23688586;28045076;33035772;40997131", "class_list": "", "function": "Histone-binding protein (By similarity). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (PubMed:22730381). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (PubMed:33035772)., [UniProtKB, UniProtKB, PubMed, PubMed]; PHF14 expression was upregulated in fibrotic models in vivo and in vitro, and the TGF-beta/smad3/PHF14 pathway acted as a self-limiting mechanism in the TGF-beta-dominated renal pro-fibrotic process by suppressing PDGFR-alpha expression. Erratum:[Sci Rep. 2020 Apr 2;10(1):6036. doi: 10.1038/s41598-020-62765-7. PMID: 32242053] Publication Status: Online-Only, [RefSeq, PubMed]; PHF14 is required for germinal center B cell development., [RefSeq, PubMed]; Results indicated that PHF14 might be an epigenetic regulator and play an important role in the development of multiple organs in mouse, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q810Z6;Q8C284;Q8CGF8;Q9D1Q8", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:0140566 histone reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9D4H9-2", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHQ3-1", "uniprot_id": [ { "id": "PP16B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHQ3", "type": "external" } ], "mass": 63571.0, "length": 568, "protein_name": "Protein phosphatase 1 regulatory inhibitor subunit 16B", "gene_name": "Ppp1r16b", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory inhibitor subunit 16B", "refseq_ac": [ { "id": "NP_001153134", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153134", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r16b", "gene_names_refseq": "ANKRD4; C130078N17Rik; Ppp1r16b; TIMAP; Wdt4", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory inhibitor subunit 16B; CAAX box protein TIMAP; TGF-beta-inhibited membrane-associated protein", "protein_names_refseq": "CAAX box protein TIMAP; TGF-beta-inhibited membrane-associated protein; protein phosphatase 1 regulatory inhibitor subunit 16B; protein phosphatase 1, regulatory (inhibitor) subunit 16B; whn-dependent transcript 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:228852)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12638124;21183079;21750661;21907835;27709267;31315927;34678516", "class_list": "", "function": "MRNA is located in cell bodies and dendrites of neurons in four distinct regions of the brain., [RefSeq, PubMed]; Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (PubMed:21907835). Involved in the regulation of the PI3K/AKT signaling pathway (By similarity). Involved in the regulation of angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Involved in the regulation of endothelial cell filopodia extension (By similarity). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (By similarity). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (By similarity). Involved in the dephosphorylation of EEF1A1 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; TIMAP is suppressed by TGFbeta via HDAC3-associated Smad signaling., [RefSeq, PubMed]; These data confirmed the barrier-protective role of TIMAP, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017020 myosin phosphatase regulator activity;GO:0004857 enzyme inhibitor activity;GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0061028 establishment of endothelial barrier;GO:0051489 regulation of filopodium assembly;GO:1903670 regulation of sprouting angiogenesis;GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8VHQ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63330-1", "uniprot_id": [ { "id": "PP2AA_MOUSE", "url": "https://www.uniprot.org/uniprot/P63330", "type": "external" } ], "mass": 35608.0, "length": 309, "protein_name": "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform", "gene_name": "Ppp2ca", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform", "refseq_ac": [ { "id": "NP_062284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062284", "type": "external" } ], "gene_names_uniprotkb": "Ppp2ca", "gene_names_refseq": "PP2A; Ppp2ca", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; 3.1.3.16; PP2A-alpha", "protein_names_refseq": "PP2A-alpha; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); Parkinson's disease (Disease Ontology:DOID:14330); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:19052); (R-MMU-113501); (R-MMU-1295596); (R-MMU-141430); (R-MMU-141444); (R-MMU-180024); (R-MMU-195253); (R-MMU-196299); (R-MMU-198753); (R-MMU-202670); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-2995383); (R-MMU-389356); (R-MMU-389513); (R-MMU-432142); (R-MMU-4641262); (R-MMU-5663220); (R-MMU-5673000); (R-MMU-5675221); (R-MMU-6804757); (R-MMU-6811558); (R-MMU-68877); (R-MMU-69231); (R-MMU-69273); (R-MMU-9648025); (R-MMU-975957); (R-MMU-9833482); (R-MMU-9860927)", "pathway_count": 29, "publication_count": 32, "publication_id_list": "10441131;16258073;16764867;18084284;18160256;18208556;18596935;20636478;21244478;21672589;22729898;23681232;24117685;24156551;24395787;25438055;25546391;25567480;26974206;27329844;28465465;29416710;30611118;32517647;33300544;33505023;33603756;34428180;36706705;39025841;7510677;9920888", "class_list": "", "function": "Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (By similarity). PP2A is the major phosphatase for microtubule-associated proteins (MAPs) (By similarity). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (By similarity). Cooperates with SGO2A to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (PubMed:18084284). Can dephosphorylate various proteins, such as AXIN1, p53/TP53, PIM3, WEE1 (By similarity). Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (By similarity). Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC (PubMed:25438055). Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (By similarity). Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome (PubMed:28465465). Catalyzes dephosphorylation of PIM3, promoting PIM3 ubiquitination and proteasomal degradation (By similarity). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (PubMed:26974206, PubMed:33505023). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (PubMed:33505023). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (By similarity). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (By similarity). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (By similarity). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (By similarity). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, PPP2CA catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; The PP2A regulator IER5L supports prostate cancer progression. Erratum:[Cell Death Dis. 2025 Jul 22;16(1):545. doi: 10.1038/s41419-025-07802-x. PMID: 40695780] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88591;P13353;Q5SNY5", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.1.1.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.89", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" } ], "go_molecular_function": "GO:0031698 beta-2 adrenergic receptor binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1904539 negative regulation of glycolytic process through fructose-6-phosphate;GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0000278 mitotic cell cycle;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0010469 regulation of signaling receptor activity", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P63330-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63955-1", "uniprot_id": [ { "id": "PO4F3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q63955", "type": "external" } ], "mass": 37016.0, "length": 338, "protein_name": "POU domain, class 4, transcription factor 3", "gene_name": "Pou4f3", "organism": "Mouse", "refseq_name": "POU domain, class 4, transcription factor 3", "refseq_ac": [ { "id": "NP_620395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620395", "type": "external" } ], "gene_names_uniprotkb": "Pou4f3; Brn-3.1; Brn-3c; Brn3c", "gene_names_refseq": "Brn3.1; Brn3c; Pou4f3; ddl; dreidel", "protein_names_uniprotkb": "POU domain, class 4, transcription factor 3; Brain-3C; Brain-specific homeobox/POU domain protein 3C; Brn-3.1; Brn-3C", "protein_names_refseq": "POU domain, class 4, transcription factor 3; brain-3C; brain-specific homeobox POU domain protein 3C; brn-3C", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 15 (Disease Ontology:DOID:0110546)", "pathway": " (mmu:18998)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;22326227;24643061;7935408;8162704;8248179;8290353;8637595", "class_list": "", "function": "Acts as a transcriptional activator (PubMed:7935408, PubMed:8290353). Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:7935408). Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (PubMed:8637595)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H6N6", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0042472 inner ear morphogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q63955-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZ97-1", "uniprot_id": [ { "id": "PRDM8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZ97", "type": "external" } ], "mass": 71729.0, "length": 688, "protein_name": "PR domain zinc finger protein 8", "gene_name": "Prdm8", "organism": "Mouse", "refseq_name": "PR domain zinc finger protein 8", "refseq_ac": [ { "id": "NP_084223", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084223", "type": "external" } ], "gene_names_uniprotkb": "Prdm8", "gene_names_refseq": "4930565F05Rik; PFM5; Prdm8", "protein_names_uniprotkb": "PR domain zinc finger protein 8; 2.1.1.-; PR domain-containing protein 8", "protein_names_refseq": "PR domain zinc finger protein 8; PR domain-containing protein 8", "tax_id": 10090, "disease": "progressive myoclonus epilepsy 10 (Disease Ontology:DOID:0111445)", "pathway": " (mmu:77630)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;19616129;19646955;22284184;26023183", "class_list": "", "function": "PRDM8 repressed the expression of steroidogenic markers, p450c17c and LHR, which indicates its regulatory role in mouse testis development., [RefSeq, PubMed]; Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (PubMed:19646955). Histone methyltransferase activity has not been confirmed in other species. Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (PubMed:19646955). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (PubMed:22284184). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (PubMed:26023183)., [UniProtKB, PubMed, PubMed, PubMed]; These results show that Prdm8 expression is tightly regulated in a spatio-temporal manner during neural development and mainly restricted to postmitotic neurons, except in the spinal cord., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RU90", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0042054 histone methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0035097 histone methyltransferase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0021952 central nervous system projection neuron axonogenesis;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BZ97-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIG4-1", "uniprot_id": [ { "id": "PPR3F_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIG4", "type": "external" } ], "mass": 84120.0, "length": 799, "protein_name": "Protein phosphatase 1 regulatory subunit 3F", "gene_name": "Ppp1r3f", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 3F isoform 2", "refseq_ac": [ { "id": "NP_613071", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_613071", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r3f; DXImx48e", "gene_names_refseq": "DXImx48e; Ppp1r3f; R3F; RF3; Sfc15", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 3F; R3F", "protein_names_refseq": "protein phosphatase 1 regulatory subunit 3F isoform 2; protein phosphatase 1, regulatory (inhibitor) subunit 3F", "tax_id": 10090, "disease": "", "pathway": " (mmu:54646)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10857745;21183079;21668450;21750661;40885482", "class_list": "glycogene", "function": "Glycogen-targeting subunit for protein phosphatase 1 (PP1)., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 58, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B1AW09;B1AW10;Q3UGL4;Q6PCL6", "ec_number_list": [], "go_molecular_function": "GO:0008157 protein phosphatase 1 binding;GO:0019903 protein phosphatase binding;GO:2001069 glycogen binding", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0016020 membrane", "go_biological_process": "GO:0005979 regulation of glycogen biosynthetic process;GO:2000465 regulation of glycogen (starch) synthase activity", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9JIG4-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100000001001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2M7-1", "uniprot_id": [ { "id": "PMM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2M7", "type": "external" } ], "mass": 27657.0, "length": 242, "protein_name": "Phosphomannomutase 2", "gene_name": "Pmm2", "organism": "Mouse", "refseq_name": "phosphomannomutase 2 isoform 1", "refseq_ac": [ { "id": "NP_058577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058577", "type": "external" } ], "gene_names_uniprotkb": "Pmm2", "gene_names_refseq": "Pmm2", "protein_names_uniprotkb": "Phosphomannomutase 2; 5.4.2.8; PMM 2", "protein_names_refseq": "phosphomannomutase 2 isoform 1", "tax_id": 10090, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); congenital disorder of glycosylation Ia (Disease Ontology:DOID:0080552); congenital disorder of glycosylation (Disease Ontology:DOID:5212)", "pathway": " (mmu:54128); (R-MMU-446205)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11404002;16115222;16847317;23806337;27053713;31219806;32152506;34428180;35789514", "class_list": "glycogene", "function": "A functional platform for the selection of pathogenic variants of PMM2 amenable to rescue via the use of pharmacological chaperones., [RefSeq, PubMed]; Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions., [UniProtKB]; Pmm2 immunoreactivity seen in prenatal brain until postnatal and adult stage and restricted in neuronal cell bodies., [RefSeq, PubMed]; These results indicate that Pmm2 is essential for early development of mice., [RefSeq, PubMed]; This functional mouse model of PMM2-CDG, in vitro assays and identification of the novel gp130 biomarker all shed light on the human disease, and moreover, provide the essential tools to test potential therapeutics for this untreatable disease., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.4.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.8", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004615 phosphomannomutase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006487 protein N-linked glycosylation;GO:0006013 mannose metabolic process;GO:0009298 GDP-mannose biosynthetic process;GO:0061728 GDP-mannose biosynthetic process from mannose;GO:0061729 GDP-D-mannose biosynthetic process from fructose-6-phosphate", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9Z2M7-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R5A0-1", "uniprot_id": [ { "id": "SMYD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R5A0", "type": "external" } ], "mass": 49567.0, "length": 433, "protein_name": "N-lysine methyltransferase SMYD2", "gene_name": "Smyd2", "organism": "Mouse", "refseq_name": "N-lysine methyltransferase SMYD2", "refseq_ac": [ { "id": "NP_081072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081072", "type": "external" } ], "gene_names_uniprotkb": "Smyd2", "gene_names_refseq": "1110020E07Rik; 4930402C15; KMT3C; Smyd2; Zmynd14", "protein_names_uniprotkb": "N-lysine methyltransferase SMYD2; 2.1.1.-; 2.1.1.354; Histone methyltransferase SMYD2; SET and MYND domain-containing protein 2", "protein_names_refseq": "N-lysine methyltransferase SMYD2; SET and MYND domain-containing protein 2; histone methyltransferase SMYD2", "tax_id": 10090, "disease": "", "pathway": " (mmu:226830); (R-MMU-3214841); (R-MMU-6804760)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "16805913;17108971;18065756;20305823;37615725;38243079;38770649", "class_list": "", "function": "Lysine methyltransferase SMYD2 enhances androgen receptor signaling to modulate CRPC cell resistance to enzalutamide., [RefSeq, PubMed]; Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'., [UniProtKB, UniProtKB, PubMed]; Results show that Smyd2 negatively regulates p53-responsive genes in a p53-dependent manner, [RefSeq, PubMed]; SMYD2 regulates vascular smooth muscle cell phenotypic switching and intimal hyperplasia via interaction with myocardin. Publication Status: Online-Only, [RefSeq, PubMed]; SMYD2-Methylated PPARgamma Facilitates Hypoxia-Induced Pulmonary Hypertension by Activating Mitophagy., [RefSeq, PubMed]; Sin3A-mediated deacetylation within the coding regions of active genes is directly linked to the histone methyltransferase activity of Smyd2 [Symd2] Publication Status: Online-Only, [RefSeq, PubMed]; Smyd2, similar to Smyd3, interacts with RNA Polymerase II as well as to the RNA helicase, HELZ Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBQ2", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000993 RNA polymerase II complex binding;GO:0002039 p53 binding;GO:0046975 histone H3K36 methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R5A0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R5B6-1", "uniprot_id": [ { "id": "SPSB4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R5B6", "type": "external" } ], "mass": 30286.0, "length": 273, "protein_name": "SPRY domain-containing SOCS box protein 4", "gene_name": "Spsb4", "organism": "Mouse", "refseq_name": "SPRY domain-containing SOCS box protein 4", "refseq_ac": [ { "id": "NP_660116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660116", "type": "external" } ], "gene_names_uniprotkb": "Spsb4; Ssb4", "gene_names_refseq": "D030068E18Rik; SSB-4; Spsb4; Ssb4", "protein_names_uniprotkb": "SPRY domain-containing SOCS box protein 4; SSB-4", "protein_names_refseq": "SPRY domain-containing SOCS box 4; SPRY domain-containing SOCS box protein 4; SPRY domain-containing SOCS box protein SSB-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:211949); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "16369487;20561531;20603330", "class_list": "", "function": "SPSB1 and SPSB4 bind strongly to both Par-4 and VASA peptides., [RefSeq, PubMed]; Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (By similarity). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity). Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of the EphB2/CTF2 (By similarity). Regulates cellular clock function by mediating ubiquitination and proteasomal degradation of the circadian transcriptional repressor NR1D1 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJI9;Q8VHS8", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0042752 regulation of circadian rhythm;GO:0048511 rhythmic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R5B6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08103-1", "uniprot_id": [ { "id": "HCK_MOUSE", "url": "https://www.uniprot.org/uniprot/P08103", "type": "external" } ], "mass": 59129.0, "length": 524, "protein_name": "Tyrosine-protein kinase HCK", "gene_name": "Hck", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase HCK isoform p56Hck", "refseq_ac": [ { "id": "NP_001165588", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165588", "type": "external" } ], "gene_names_uniprotkb": "Hck", "gene_names_refseq": "Bmk; Hck", "protein_names_uniprotkb": "Tyrosine-protein kinase HCK; 2.7.10.2; B-cell/myeloid kinase; BMK; Hematopoietic cell kinase; Hemopoietic cell kinase; p56-HCK/p59-HCK", "protein_names_refseq": "B cell/myeloid kinase; hematopoietic cell kinase; hemopoietic cell kinase; p56-HCK/p59-HCK; tyrosine-protein kinase HCK isoform p56Hck; tyrosine-protein kinase HCK", "tax_id": 10090, "disease": "intestinal cancer (Disease Ontology:DOID:10155); Goldenhar syndrome (Disease Ontology:DOID:2907); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:15162); (R-MMU-2029481); (R-MMU-912631); (R-MMU-9674555); (R-MMU-9705462)", "pathway_count": 5, "publication_count": 25, "publication_id_list": "10547366;10799548;10934191;12235133;14551197;16684964;16809022;17513616;18246197;18625913;1875927;19144319;19897576;19903482;21750661;26495903;30084848;3317404;34428180;3684607;40885482;8125254;8666673;9400828;9916742", "class_list": "", "function": "Alternate protein isoforms arise through the use of a non-AUG (CUG), and a downstream in-frame AUG, translation initiation codons, in mouse and human., [RefSeq, PubMed]; Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may play a role in the innate immune response and the STAT5 signaling pathway. Alternative translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization. [provided by RefSeq, Feb 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VH03;Q3UD17", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" } ], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane", "go_biological_process": "GO:0071801 regulation of podosome assembly;GO:0006954 inflammatory response;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0018108 peptidyl-tyrosine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P08103-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAN6-1", "uniprot_id": [ { "id": "GTSF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAN6", "type": "external" } ], "mass": 19083.0, "length": 167, "protein_name": "Gametocyte-specific factor 1", "gene_name": "Gtsf1", "organism": "Mouse", "refseq_name": "gametocyte-specific factor 1", "refseq_ac": [ { "id": "NP_083073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083073", "type": "external" } ], "gene_names_uniprotkb": "Gtsf1; Cue110; Fam112b", "gene_names_refseq": "1700006H03Rik; Cue110; Gtsf1", "protein_names_uniprotkb": "Gametocyte-specific factor 1; Protein FAM112B", "protein_names_refseq": "gametocyte-specific factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74174)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17919994;18299400;18706558;19735653;21750661;29437694;33789107;35772669", "class_list": "", "function": "Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons., [RefSeq, PubMed]; Expression pattern of Gtsf1 and its high conservation suggests that it may play an important role in germ cell development., [RefSeq, PubMed]; GTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute proteins., [RefSeq, PubMed]; Our findings indicate that GTSF1 is a crucial factor for the slicing of target RNAs by PIWI-piRNAs and thus affects secondary piRNA biogenesis in prospermatogonia., [RefSeq, PubMed]; Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells., [UniProtKB, PubMed]; Results indicate that Gtsf1/Cue110 is required for spermatogenesis and involved in retrotransposon suppression in male germ cells., [RefSeq, PubMed]; The Cue110 gene is expressed predominantly in male germ cells at stages from the pachytene spermatocytes to round spermatids, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000049 tRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0071547 piP-body", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0140965 secondary piRNA processing;GO:0140991 piRNA-mediated gene silencing by mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9DAN6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SF07-1", "uniprot_id": [ { "id": "IF2B2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SF07", "type": "external" } ], "mass": 65584.0, "length": 592, "protein_name": "Insulin-like growth factor 2 mRNA-binding protein 2", "gene_name": "Igf2bp2", "organism": "Mouse", "refseq_name": "insulin-like growth factor 2 mRNA-binding protein 2", "refseq_ac": [ { "id": "NP_898850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898850", "type": "external" } ], "gene_names_uniprotkb": "Igf2bp2; Imp2; Vickz2", "gene_names_refseq": "C330012H03Rik; IMP-2; Igf2bp2; Imp2; Neilsen", "protein_names_uniprotkb": "Insulin-like growth factor 2 mRNA-binding protein 2; IGF-II mRNA-binding protein 2; IGF2 mRNA-binding protein 2; IMP-2; VICKZ family member 2", "protein_names_refseq": "IGF-II mRNA-binding protein 2; IGF2 mRNA-binding protein 2; VICKZ family member 2; insulin-like growth factor 2 mRNA-binding protein 2; insulin-like growth factor 2, binding protein 2", "tax_id": 10090, "disease": "acquired metabolic disease (Disease Ontology:DOID:0060158); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:319765)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10875929;15225648;15601260;16049158;19131326;21183079;21750661;34428180;34887587;35820727;38229002;38281999;38844111;38861275", "class_list": "", "function": "CaMKIIdelta, Stabilized by RNA N6-Methyladenosine Reader IGF2BP2, Boosts Coxsackievirus B3-Induced Myocardial Inflammation via Interacting with TIRAP., [RefSeq, PubMed]; FBW7/GSK3beta mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer. Publication Status: Online-Only, [RefSeq, PubMed]; IGF2BP2 Maintains Retinal Pigment Epithelium Homeostasis by Stabilizing PAX6 and OTX2., [RefSeq, PubMed]; Inhibition of Mettl3 ameliorates osteoblastic senescence by mitigating m6A modifications on Slc1a5 via Igf2bp2-dependent mechanisms., [RefSeq, PubMed]; RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts (By similarity). Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6X8Z4;Q3TCU4;Q7TQF9", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0045182 translation regulator activity;GO:0048027 mRNA 5'-UTR binding;GO:1990247 N6-methyladenosine-containing RNA reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0000932 P-body", "go_biological_process": "GO:0070934 CRD-mediated mRNA stabilization;GO:0007399 nervous system development;GO:0097009 energy homeostasis;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0017148 negative regulation of translation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q5SF07-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHD1-1", "uniprot_id": [ { "id": "POC1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHD1", "type": "external" } ], "mass": 53504.0, "length": 476, "protein_name": "POC1 centriolar protein homolog B", "gene_name": "Poc1b", "organism": "Mouse", "refseq_name": "POC1 centriolar protein homolog B", "refseq_ac": [ { "id": "NP_082016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082016", "type": "external" } ], "gene_names_uniprotkb": "Poc1b; Wdr51b", "gene_names_refseq": "4933430F16Rik; Poc1b; Wdr51b", "protein_names_uniprotkb": "POC1 centriolar protein homolog B; WD repeat-containing protein 51B", "protein_names_refseq": "POC1 centriolar protein homolog B; WD repeat domain 51B; WD repeat-containing protein 51B", "tax_id": 10090, "disease": "oligoasthenoteratozoospermia (Disease Ontology:DOID:0070311); cone-rod dystrophy 20 (Disease Ontology:DOID:0111026)", "pathway": " (mmu:382406)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25044745;25428506;31219806;37070736", "class_list": "", "function": "Homozygous frameshift variant in POC1B causes male infertility with oligoasthenoteratozoospermia in human and mice., [RefSeq, PubMed]; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation. Required for retinal integrity. Acts as a positive regulator of centriole elongation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0007283 spermatogenesis;GO:0008283 cell population proliferation;GO:0000902 cell morphogenesis;GO:0007338 single fertilization;GO:0001895 retina homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BHD1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60676-1", "uniprot_id": [ { "id": "PPP5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60676", "type": "external" } ], "mass": 56877.0, "length": 499, "protein_name": "Serine/threonine-protein phosphatase 5", "gene_name": "Ppp5c", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 5 isoform 1", "refseq_ac": [ { "id": "NP_035285", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035285", "type": "external" } ], "gene_names_uniprotkb": "Ppp5c", "gene_names_refseq": "PP5; Ppp5c", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 5; 3.1.3.16; PP5; PPT; Protein phosphatase T", "protein_names_refseq": "ANP receptor; protein phosphatase T; serine/threonine-protein phosphatase 5 isoform 1; serine/threonine-protein phosphatase 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:19060); (R-MMU-5675221); (R-MMU-5693565); (R-MMU-8939211)", "pathway_count": 4, "publication_count": 18, "publication_id_list": "12522145;16790549;17376776;21750661;21994940;22526606;22872234;25428506;25605945;26740625;30262665;31219806;31425567;34428180;34490876;37828378;7972012;9195923", "class_list": "", "function": "During inflammatory response to the bacterial LPS in the heart of transgenic mouse model with cardiac myocyte directed overexpression of protein phosphatase 5 (PP5) basal cardiac contractility was reduced, but LPS-induced cardiac dysfunction was less pronounced compared to wild type mice. PP5 increases stress tolerance of cardiac myocytes by downregulation of NF-kappaB signaling and upregulation of HSP25 expression. Publication Status: Online-Only, [RefSeq, PubMed]; PP5 directly interacts with and dephosphorylates p53 at multiple serine/threonine residues, resulting in inhibition of p53-mediated transcriptional activity., [RefSeq, PubMed]; PSPC1 regulates CHK1 phosphorylation through phase separation and participates in mouse oocyte maturation., [RefSeq, PubMed]; Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT (PubMed:17376776, PubMed:21994940, PubMed:22526606). Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses (By similarity). Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1 (PubMed:17376776). Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress (By similarity). Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function (PubMed:21994940). Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1 (PubMed:21994940). Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT (By similarity). Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2 (By similarity). Dephosphorylate FNIP1, disrupting interaction with HSP90AA1/Hsp90 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G5E819;O35299", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043204 perikaryon", "go_biological_process": "GO:1904550 response to arachidonate;GO:0010288 response to lead ion;GO:0043066 negative regulation of apoptotic process;GO:0001933 negative regulation of protein phosphorylation;GO:0043278 response to morphine", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q60676-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62715-1", "uniprot_id": [ { "id": "PP2AB_MOUSE", "url": "https://www.uniprot.org/uniprot/P62715", "type": "external" } ], "mass": 35575.0, "length": 309, "protein_name": "Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform", "gene_name": "Ppp2cb", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform 1", "refseq_ac": [ { "id": "NP_059070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059070", "type": "external" } ], "gene_names_uniprotkb": "Ppp2cb", "gene_names_refseq": "D8Ertd766e; PP2Ac; Ppp2cb", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; 3.1.3.16; PP2A-beta", "protein_names_refseq": "PP2A-beta; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:19053); (R-MMU-113501); (R-MMU-1295596); (R-MMU-141430); (R-MMU-141444); (R-MMU-180024); (R-MMU-195253); (R-MMU-196299); (R-MMU-198753); (R-MMU-202670); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-389356); (R-MMU-389513); (R-MMU-432142); (R-MMU-4641262); (R-MMU-5663220); (R-MMU-5673000); (R-MMU-5675221); (R-MMU-6804757); (R-MMU-6811558); (R-MMU-68877); (R-MMU-69231); (R-MMU-69273); (R-MMU-9648025); (R-MMU-9833482)", "pathway_count": 26, "publication_count": 10, "publication_id_list": "10441131;24713870;25546391;27851811;33300544;34428180;35068054;35820727;7510677;8077208", "class_list": "", "function": "Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation., [UniProtKB, UniProtKB]; Protein phosphatase 2A catalytic subunit beta suppresses PMA/ionomycin-induced T-cell activation by negatively regulating PI3K/Akt signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P11082", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.1.1.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.89", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0044325 transmembrane transporter binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0000278 mitotic cell cycle;GO:0010288 response to lead ion;GO:0010629 negative regulation of gene expression;GO:0042542 response to hydrogen peroxide", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P62715-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62141-4", "uniprot_id": [ { "id": "SIN3B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62141", "type": "external" } ], "mass": 126405.0, "length": 1098, "protein_name": "Paired amphipathic helix protein Sin3b", "gene_name": "Sin3b", "organism": "Mouse", "refseq_name": "paired amphipathic helix protein Sin3b isoform 2", "refseq_ac": [ { "id": "NP_001106719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106719", "type": "external" } ], "gene_names_uniprotkb": "Sin3b; Kiaa0700", "gene_names_refseq": "2810430C10Rik; Sin3b", "protein_names_uniprotkb": "Paired amphipathic helix protein Sin3b; Histone deacetylase complex subunit Sin3b; Transcriptional corepressor Sin3b", "protein_names_refseq": "SIN3 homolog B, transcription regulator; histone deacetylase complex subunit Sin3b; paired amphipathic helix protein Sin3b isoform 2; paired amphipathic helix protein Sin3b; transcriptional corepressor Sin3b; transcriptional regulator, SIN3 yeast homolog B", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:20467); (R-MMU-400206); (R-MMU-8936459); (R-MMU-9707564)", "pathway_count": 4, "publication_count": 28, "publication_id_list": "10620510;11101889;11909966;12398767;15226430;16288918;16787967;20170641;20173027;21183079;22476904;25428506;25605945;28379941;30084848;30213984;30779550;31219806;31599954;32245798;34428180;34887587;36210013;38254205;7889570;8521822;9139820;9702189", "class_list": "", "function": "Active compounds showed a new chemo-type for inhibitors of the REST/NRSF-mSin3 interaction, raising the possibility of new therapies for neuropathies caused by dysregulation of REST/NRSF. Publication Status: Online-Only, [RefSeq, PubMed]; Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression (PubMed:22476904). As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2. SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Chromatin accessibility and cell cycle progression are controlled by the HDAC-associated Sin3B protein in murine hematopoietic stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; Coregulator Sin3a Promotes Postnatal Murine beta-Cell Fitness by Regulating Genes in Ca(2+) Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O54976;Q6A013;Q8VCB8;Q8VDZ5", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0070822 Sin3-type complex;GO:0001741 XY body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030336 negative regulation of cell migration;GO:0045892 negative regulation of DNA-templated transcription;GO:0048738 cardiac muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q62141-4", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R080-1", "uniprot_id": [ { "id": "GTSE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R080", "type": "external" } ], "mass": 78751.0, "length": 741, "protein_name": "G2 and S phase-expressed protein 1", "gene_name": "Gtse1", "organism": "Mouse", "refseq_name": "G2 and S phase-expressed protein 1", "refseq_ac": [ { "id": "NP_001162143", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162143", "type": "external" } ], "gene_names_uniprotkb": "Gtse1; B99", "gene_names_refseq": "B99; Gtse-1; Gtse1", "protein_names_uniprotkb": "G2 and S phase-expressed protein 1; GTSE-1; Protein B99", "protein_names_refseq": "G2 and S phase-expressed protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:29870); (R-MMU-69481); (R-MMU-8852276)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10984615;17242355;19144319;21183079;31219806;31932847;35820727;9724637", "class_list": "", "function": "Clathrin's adaptor interaction sites are repurposed to stabilize microtubules during mitosis., [RefSeq, PubMed]; May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O89015;Q9CSG9", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0015630 microtubule cytoskeleton;GO:0005881 cytoplasmic microtubule", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R080-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19157-1", "uniprot_id": [ { "id": "GSTP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P19157", "type": "external" } ], "mass": 23609.0, "length": 210, "protein_name": "Glutathione S-transferase P 1", "gene_name": "Gstp1", "organism": "Mouse", "refseq_name": "glutathione S-transferase P 1", "refseq_ac": [ { "id": "NP_038569", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038569", "type": "external" } ], "gene_names_uniprotkb": "Gstp1; Gstpib", "gene_names_refseq": "Gstp1; GstpiB", "protein_names_uniprotkb": "Glutathione S-transferase P 1; 2.5.1.18; GST YF-YF; GST class-pi; GST-piB; Gst P1; Preadipocyte growth factor", "protein_names_refseq": "GST YF-YF; GST class-pi; GST-piB; Gst p-1; glutathione S-transferase P 1; gst P1; preadipocyte growth factor", "tax_id": 10090, "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); colorectal adenoma (Disease Ontology:DOID:0050860); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); myelodysplastic syndrome (Disease Ontology:DOID:0050908); pre-malignant neoplasm (Disease Ontology:DOID:0060071); drug allergy (Disease Ontology:DOID:0060500); late onset Parkinson's disease (Disease Ontology:DOID:0060892); prostate cancer (Disease Ontology:DOID:10283); lymphoid leukemia (Disease Ontology:DOID:1037); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); osteoporosis (Disease Ontology:DOID:11476); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); allergic disease (Disease Ontology:DOID:1205); Graves' disease (Disease Ontology:DOID:12361); cholestasis (Disease Ontology:DOID:13580); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); respiratory system disease (Disease Ontology:DOID:1579); breast cancer (Disease Ontology:DOID:1612); congenital heart disease (Disease Ontology:DOID:1682); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); colon adenocarcinoma (Disease Ontology:DOID:234); multiple sclerosis (Disease Ontology:DOID:2377); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); testicular cancer (Disease Ontology:DOID:2998); acute kidney failure (Disease Ontology:DOID:3021); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); carotid artery disease (Disease Ontology:DOID:3407); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); toxic encephalopathy (Disease Ontology:DOID:3602); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); pulmonary fibrosis (Disease Ontology:DOID:3770); bronchus carcinoma (Disease Ontology:DOID:3904); lung non-small cell carcinoma (Disease Ontology:DOID:3908); liver disease (Disease Ontology:DOID:409); conjunctivochalasis (Disease Ontology:DOID:4250); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); movement disease (Disease Ontology:DOID:480); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); cholangiocarcinoma (Disease Ontology:DOID:4947); bone marrow disease (Disease Ontology:DOID:4961); peripheral nervous system disease (Disease Ontology:DOID:574); hepatocellular carcinoma (Disease Ontology:DOID:684); hematopoietic system disease (Disease Ontology:DOID:74); peritonitis (Disease Ontology:DOID:8283); lung disease (Disease Ontology:DOID:850); prostate carcinoma in situ (Disease Ontology:DOID:8634); myeloid leukemia (Disease Ontology:DOID:8692); psoriasis (Disease Ontology:DOID:8893); acute myeloid leukemia (Disease Ontology:DOID:9119); type 2 diabetes mellitus (Disease Ontology:DOID:9352); meningitis (Disease Ontology:DOID:9471); multiple myeloma (Disease Ontology:DOID:9538); senile cataract (Disease Ontology:DOID:9669); pulmonary emphysema (Disease Ontology:DOID:9675); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:14870); (R-MMU-156590); (R-MMU-3299685); (R-MMU-6798695); (R-MMU-9753281)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "21750661;23806337;2388840;34428180;36210013;37453647;37507081;38169591;38479222;39927985;7982937;8135745;8145243;8605288;9446594", "class_list": "", "function": "Catalyzes conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Acts as a negative regulator of ferroptosis by mediating glutathione conjugation and detoxification of 4-hydroxynonenal (4-HNE) reactive aldehyde. Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles., [UniProtKB, UniProtKB]; GSTP alleviates acute lung injury by S-glutathionylation of KEAP1 and subsequent activation of NRF2 pathway., [RefSeq, PubMed]; SIRT5-related lysine demalonylation of GSTP1 contributes to cardiomyocyte pyroptosis suppression in diabetic cardiomyopathy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 70, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNY4", "ec_number_list": [ { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0005504 fatty acid binding;GO:0015643 toxic substance binding;GO:0019901 protein kinase binding;GO:0035730 S-nitrosoglutathione binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0032991 protein-containing complex;GO:0097057 TRAF2-GSTP1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response;GO:0032869 cellular response to insulin stimulus;GO:0032930 positive regulation of superoxide anion generation;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P19157-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64279-1", "uniprot_id": [ { "id": "HAND1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64279", "type": "external" } ], "mass": 23806.0, "length": 216, "protein_name": "Heart- and neural crest derivatives-expressed protein 1", "gene_name": "Hand1", "organism": "Mouse", "refseq_name": "heart- and neural crest derivatives-expressed protein 1", "refseq_ac": [ { "id": "NP_032239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032239", "type": "external" } ], "gene_names_uniprotkb": "Hand1; Ehand; Hxt; Thing1", "gene_names_refseq": "Ehand1; Hand1; Hxt; Th1; Thing1; bHLHa27; eHAND", "protein_names_uniprotkb": "Heart- and neural crest derivatives-expressed protein 1; Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast; Th1; Thing-1; eHAND", "protein_names_refseq": "extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; heart and neural crest derivatives expressed transcript 1; heart- and neural crest derivatives-expressed protein 1; helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast; thing-1", "tax_id": 10090, "disease": "hypoplastic left heart syndrome (Disease Ontology:DOID:9955)", "pathway": " (mmu:15110)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10924525;16759287;17891141;21559426;21750661;28576769;7649392;7671815;7791788;9500551", "class_list": "", "function": "Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (PubMed:16759287, PubMed:9500551). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (PubMed:7791788). Acts as a transcriptional repressor of SOX15 (PubMed:16759287). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q61099", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q64279-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64524-1", "uniprot_id": [ { "id": "H2B2E_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64524", "type": "external" } ], "mass": 13993.0, "length": 126, "protein_name": "Histone H2B type 2-E", "gene_name": "H2bc21", "organism": "Mouse", "refseq_name": "histone H2B type 2-E", "refseq_ac": [ { "id": "NP_835586", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_835586", "type": "external" } ], "gene_names_uniprotkb": "H2bc21; Hist2h2be", "gene_names_refseq": "H2b-613; H2bc21; Hist2h2be", "protein_names_uniprotkb": "Histone H2B type 2-E; H2B-clustered histone 21; H2b 613", "protein_names_refseq": "histone 2, H2be; histone H2B type 2-E; histone cluster 2, H2be", "tax_id": 10090, "disease": "", "pathway": " (mmu:319190); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214847); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-606279); (R-MMU-69473); (R-MMU-8866654); (R-MMU-8936459); (R-MMU-9018519); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 21, "publication_count": 13, "publication_id_list": "12408966;15197225;16039583;20647423;21925322;22389435;24681537;27105115;30154464;31645732;32822587;35984892;8858345", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family, and generates two transcripts through the use of a putative stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0001530 lipopolysaccharide binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000786 nucleosome", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q64524-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKV2-1", "uniprot_id": [ { "id": "CILK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKV2", "type": "external" } ], "mass": 70592.0, "length": 629, "protein_name": "Serine/threonine-protein kinase ICK", "gene_name": "Cilk1", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase ICK", "refseq_ac": [ { "id": "NP_001157252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157252", "type": "external" } ], "gene_names_uniprotkb": "Cilk1; Ick", "gene_names_refseq": "2210420N10Rik; Cilk1; Ick; Mrk", "protein_names_uniprotkb": "Serine/threonine-protein kinase ICK; 2.7.11.1; Intestinal cell kinase; MAK-related kinase; MRK; mICK", "protein_names_refseq": "MAK-related kinase; intestinal cell kinase; mICK; serine/threonine-protein kinase ICK", "tax_id": 10090, "disease": "endocrine-cerebro-osteodysplasia syndrome (Disease Ontology:DOID:0060641); juvenile myoclonic epilepsy 10 (Disease Ontology:DOID:0111325)", "pathway": " (mmu:56542)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10699974;15988018;20459822;21183079;21750661;24244486;24797473;24853502;25243405;25428506;27669760;29539279;34428180", "class_list": "", "function": "Has an essential role in ciliogenesis, particularly in neuronal and retinal progenitor cells (PubMed:24797473). Phosphorylates KIF3A (PubMed:24797473). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (PubMed:24797473, PubMed:24853502). May play a role in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling -dependent manner and this regulation requires its kinase activity (PubMed:25243405)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; ICK and FBX9 are divergently transcribed from a bidirectional promoter that is GC-rich and contains a CpG island. Publication Status: Online-Only, [RefSeq, PubMed]; The expressions of ICK/MAK/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8K138", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0036064 ciliary basal body", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0035556 intracellular signal transduction;GO:0060271 cilium assembly;GO:0042073 intraciliary transport", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9JKV2-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05D44-1", "uniprot_id": [ { "id": "IF2P_MOUSE", "url": "https://www.uniprot.org/uniprot/Q05D44", "type": "external" } ], "mass": 137616.0, "length": 1216, "protein_name": "Eukaryotic translation initiation factor 5B", "gene_name": "Eif5b", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 5B", "refseq_ac": [ { "id": "NP_938045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_938045", "type": "external" } ], "gene_names_uniprotkb": "Eif5b; If2", "gene_names_refseq": "A030003E17Rik; Eif5b; IF2", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 5B; 3.6.5.3; Translation initiation factor IF-2; eIF-5B", "protein_names_refseq": "eIF-5B; eukaryotic translation initiation factor 5B; translation initiation factor IF-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:226982); (R-MMU-72706)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "12426392;15345747;17242355;17622165;18630941;19131326;19144319;21183079;25261552;26495903;30059200;31219806;34418053;34428180;34887587;37828378;39627609", "class_list": "", "function": "EIF5B overexpression promotes maturation of G0-like immature oocytes and causes cell death, an alternative to G0, in serum-starved THP1 cells., [RefSeq, PubMed]; EIF5B, the homologue of bacterial IF2, is a GTPase implicated in joining the ribosomal subunits., [RefSeq, PubMed]; Plays a role in translation initiation. Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after formation of the 80S initiation complex. Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes. In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3SYI4;Q3TQJ8;Q3UL37;Q3UM39;Q6PAI0;Q8CFF4;Q8CGD6", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0000049 tRNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse", "go_biological_process": "GO:0006413 translational initiation;GO:0006446 regulation of translational initiation;GO:0042255 ribosome assembly", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q05D44-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGD9-1", "uniprot_id": [ { "id": "IF4B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGD9", "type": "external" } ], "mass": 68840.0, "length": 611, "protein_name": "Eukaryotic translation initiation factor 4B", "gene_name": "Eif4b", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 4B", "refseq_ac": [ { "id": "NP_663600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663600", "type": "external" } ], "gene_names_uniprotkb": "Eif4b", "gene_names_refseq": "2310046H11Rik; Eif4a2; Eif4b", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4B; eIF-4B", "protein_names_refseq": "eIF-4B; eukaryotic translation initiation factor 4B", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); major depressive disorder (Disease Ontology:DOID:1470)", "pathway": " (mmu:75705); (R-MMU-156827); (R-MMU-166208); (R-MMU-429947); (R-MMU-72649); (R-MMU-72662); (R-MMU-72702); (R-MMU-72706)", "pathway_count": 8, "publication_count": 29, "publication_id_list": "10.1101/2023.09.13.557529;15345747;17242355;18630941;19131326;19144319;19289497;21183079;22645316;23749639;23806337;24129315;25153642;25280966;25605945;26495903;26848623;28135057;28528544;30059200;30084848;31219806;32152506;34428180;34887587;35820727;36288343;36852467;40021952", "class_list": "", "function": "Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3TD64", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0098794 postsynapse", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q8BGD9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERM2-1", "uniprot_id": [ { "id": "ICAM4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERM2", "type": "external" } ], "mass": 28495.0, "length": 262, "protein_name": "Intercellular adhesion molecule 4", "gene_name": "Icam4", "organism": "Mouse", "refseq_name": "intercellular adhesion molecule 4 isoform 1 precursor", "refseq_ac": [ { "id": "NP_076381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076381", "type": "external" } ], "gene_names_uniprotkb": "Icam4", "gene_names_refseq": "1810015M19Rik; Cd242; ICAM-4; Icam4", "protein_names_uniprotkb": "Intercellular adhesion molecule 4; ICAM-4", "protein_names_refseq": "LW glycoprotein; intercellular adhesion molecule 4 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:78369); (R-MMU-198933); (R-MMU-216083)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "12406883;16690966", "class_list": "", "function": "A novel second splice cDNA encodes an ICAM-4 isoform lacking the membrane-spanning domain. Erythroblasts express both isoforms. This new isoform, ICAM-4S, may modulate membrane-associated ICAM-4 binding & regulate erythroblast molecular attachments., [RefSeq, PubMed]; Functions as a receptor ligand for the monocyte/macrophage-specific ITGAX:ITGB2 integrin complex and mediates erythrophagocytosis. Receptor ligand of the platelet-specific ITGA2B:ITGB3 integrin complex involved in heterotypic cell-cell adhesion between erythrocytes and activated platelets (By similarity). In vitro, is also a receptor ligand of multiple integrin receptors complexes such ITGAL:ITGB2, ITGAM:ITGB2, ITGA5:ITGB1, ITGA5:ITGB3 and ITGA5:ITGB5 integrin complexes (PubMed:12406883)., [UniProtKB, PubMed, UniProtKB]; ICAM-4 is critical in erythroblastic island formation via ICAM-4/alpha(V) adhesion, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8K4L7;Q9CU00", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0006909 phagocytosis;GO:0033631 cell-cell adhesion mediated by integrin;GO:0007159 leukocyte cell-cell adhesion;GO:0034113 heterotypic cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9ERM2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51860-1", "uniprot_id": [ { "id": "NP1L2_MOUSE", "url": "https://www.uniprot.org/uniprot/P51860", "type": "external" } ], "mass": 52158.0, "length": 460, "protein_name": "Nucleosome assembly protein 1-like 2", "gene_name": "Nap1l2", "organism": "Mouse", "refseq_name": "nucleosome assembly protein 1-like 2", "refseq_ac": [ { "id": "NP_032697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032697", "type": "external" } ], "gene_names_uniprotkb": "Nap1l2; Bpx", "gene_names_refseq": "Bpx; Nap1l2", "protein_names_uniprotkb": "Nucleosome assembly protein 1-like 2; Brain-specific protein, X-linked; Histone chaperone NAP1L2", "protein_names_refseq": "brain-specific protein, X-linked; histone chaperone NAP1L2; nucleosome assembly protein 1-like 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:17954)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10932189;12045143;17591696;21333655;8789438", "class_list": "", "function": "Data show that Nap1l2 associates with chromatin and interacts with histones H3 and H4, and loss of Nap1l2 results in decreased histone acetylation activity, leading to transcriptional changes in differentiating neurons., [RefSeq, PubMed]; Histone chaperone (By similarity). Plays a role in the epigenetic regulation of gene expression during cellular differentiation, by regulating the acetylation status of histone H3 and therefore chromatin accessibility (PubMed:10932189, PubMed:17591696). Plays a role in the differentiation of neuronal cells (PubMed:10932189, PubMed:17591696). Increased activity during aging may suppress osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and promote their senescence; recruits SIRT1 to deacetylate histone H3 'Lys-14' at the promoter of osteogenic genes (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]; Results identified several proteins interacting with NAP1L2, including the ubiquitously expressed members of the nucleosome assembly protein family, NAP1L1 and NAP1L4., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K3R9", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding;GO:0035034 histone acetyltransferase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000785 chromatin", "go_biological_process": "GO:0045666 positive regulation of neuron differentiation;GO:0030182 neuron differentiation;GO:0006334 nucleosome assembly;GO:0040029 epigenetic regulation of gene expression;GO:2000035 regulation of stem cell division", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P51860-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMF4-1", "uniprot_id": [ { "id": "ODP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMF4", "type": "external" } ], "mass": 67942.0, "length": 642, "protein_name": "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial", "gene_name": "Dlat", "organism": "Mouse", "refseq_name": "dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial", "refseq_ac": [ { "id": "NP_663589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663589", "type": "external" } ], "gene_names_uniprotkb": "Dlat", "gene_names_refseq": "6332404G05Rik; DLTA; Dlat; PDC-E2", "protein_names_uniprotkb": "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; 2.3.1.12; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; PDC-E2; PDCE2; Pyruvate dehydrogenase complex component E2", "protein_names_refseq": "PDCE2; dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex); dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; pyruvate dehydrogenase complex component E2", "tax_id": 10090, "disease": "pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649); lactic acidosis (Disease Ontology:DOID:3650)", "pathway": " (mmu:235339); (R-MMU-204174); (R-MMU-5362517); (R-MMU-9857492); (R-MMU-9861559)", "pathway_count": 5, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;12108679;16452087;22645316;23806337;26495903;26740625;28011936;30084848;30779550;31089130;33300544;35984892;36288343;37507081;37828378;39428563;39627609;39927985", "class_list": "", "function": "Novel Insights Into DLAT's Role in Alzheimer's Disease-Related Copper Toxicity Through Microglial Exosome Dynamics., [RefSeq, PubMed]; The pyruvate dehydrogenase (PDH) complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3);. Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acetyl groups from acetyl-lipoyl moiety generated by the pyruvate dehydrogenase, leading to acetyl-CoA formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8K2G8;Q8R339;Q91ZB1", "ec_number_list": [ { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.1.3.43", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.43", "type": "external" }, { "id": "2.3.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.12", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "2.3.1.200", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.200", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0016407 acetyltransferase activity;GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0043209 myelin sheath;GO:0045254 pyruvate dehydrogenase complex;GO:0120212 sperm head-tail coupling apparatus", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006006 glucose metabolic process;GO:0006086 pyruvate decarboxylation to acetyl-CoA;GO:0042867 pyruvate catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q8BMF4-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80U72-3", "uniprot_id": [ { "id": "SCRIB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80U72", "type": "external" } ], "mass": 179750.0, "length": 1665, "protein_name": "Protein scribble homolog", "gene_name": "Scrib", "organism": "Mouse", "refseq_name": "protein scribble homolog isoform 2", "refseq_ac": [ { "id": "NP_001297471", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297471", "type": "external" } ], "gene_names_uniprotkb": "Scrib; Kiaa0147; Lap4; Scrib1", "gene_names_refseq": "CRIB; Crc; SCRIB1; Scrb1; Scrib; mKIAA0147; vartul", "protein_names_uniprotkb": "Protein scribble homolog; Protein LAP4; Scribble", "protein_names_refseq": "PDZ-domain protein scribble; circletail; protein scribble homolog isoform 2; protein scribble homolog; scribble homolog 1; scribbled homolog", "tax_id": 10090, "disease": "benign neoplasm (Disease Ontology:DOID:0060072); cancer (Disease Ontology:DOID:162); kidney cancer (Disease Ontology:DOID:263); carcinoma (Disease Ontology:DOID:305)", "pathway": " (mmu:105782); (R-MMU-9013406); (R-MMU-9696264); (R-MMU-9696270)", "pathway_count": 4, "publication_count": 20, "publication_id_list": "12112872;12499390;15182672;15345747;15649318;15806148;15878399;16611247;16687519;17242355;18329370;18716323;19041750;19144319;19386766;19458197;21183079;24129315;31599954;39627609", "class_list": "", "function": "Heterozygotes are incompletely penetrant for a circled-tail phenotype, while homozygotes die at birth of a severe neural tube defect., [RefSeq, PubMed]; Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:12499390, PubMed:18329370, PubMed:18716323, PubMed:19041750). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (PubMed:18329370). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:19458197). Functions as an activator of Rac GTPase activity (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB]; Scrb1, encodes a member of the LAP protein family related to Drosophila scribble.Disruption of scribble (Scrb1) gene causes severe neural tube defects in the circletail mouse, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 37, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q6P5H7;Q7TPH8;Q80VB1;Q8CI48;Q8VII1;Q922S3", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0035748 myelin sheath abaxonal region;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0060603 mammary gland duct morphogenesis;GO:0016080 synaptic vesicle targeting;GO:0035089 establishment of apical/basal cell polarity;GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q80U72-3", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR00-1", "uniprot_id": [ { "id": "PSMD9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR00", "type": "external" } ], "mass": 24720.0, "length": 222, "protein_name": "26S proteasome non-ATPase regulatory subunit 9", "gene_name": "Psmd9", "organism": "Mouse", "refseq_name": "26S proteasome non-ATPase regulatory subunit 9", "refseq_ac": [ { "id": "NP_080276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080276", "type": "external" } ], "gene_names_uniprotkb": "Psmd9", "gene_names_refseq": "1500011J20Rik; 2610202L11Rik; Bridge-1; P27; Psmd9", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 9; 26S proteasome regulatory subunit p27", "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 9; 26S proteasome regulatory subunit p27", "tax_id": 10090, "disease": "", "pathway": " (mmu:67151); (R-MMU-9907900)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;16879986;17242355;19131326;21183079;21750661;25153642;28528544;36288343", "class_list": "", "function": "Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; These results therefore suggest that proteasomes, particularly p27 subunit, are directly involved in the regulation of melanin biosynthesis in mouse melanoma cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TG66", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0043425 bHLH transcription factor binding", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0032024 positive regulation of insulin secretion;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0046676 negative regulation of insulin secretion;GO:0070682 proteasome regulatory particle assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9CR00-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62130-1", "uniprot_id": [ { "id": "PTN14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62130", "type": "external" } ], "mass": 135042.0, "length": 1189, "protein_name": "Tyrosine-protein phosphatase non-receptor type 14", "gene_name": "Ptpn14", "organism": "Mouse", "refseq_name": "tyrosine-protein phosphatase non-receptor type 14", "refseq_ac": [ { "id": "NP_033002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033002", "type": "external" } ], "gene_names_uniprotkb": "Ptpn14", "gene_names_refseq": "C130080N23Rik; PTP36; Ptpn14", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 14; 3.1.3.48; Protein-tyrosine phosphatase PTP36", "protein_names_refseq": "protein-tyrosine phosphatase PTP36; tyrosine-protein phosphatase non-receptor type 14", "tax_id": 10090, "disease": "", "pathway": " (mmu:19250)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "20826270;21183079;21750661;25428506;30084848;31219806;31599954;32978373;33684622;34428180;36210013;37036883;39191789;40021952;8074693", "class_list": "", "function": "MmuPV1 E7's interaction with PTPN14 delays Epithelial differentiation and contributes to virus-induced skin disease. Publication Status: Online-Only, [RefSeq, PubMed]; PTPN14 aggravates inflammation through promoting proteasomal degradation of SOCS7 in acute liver failure. Publication Status: Online-Only, [RefSeq, PubMed]; PTPN14 aggravates neointimal hyperplasia via boosting PDGFRbeta signaling in smooth muscle cells. Publication Status: Online-Only, [RefSeq, PubMed]; PTPN14 deficiency alleviates podocyte injury through suppressing inflammation and fibrosis by targeting TRIP6 in diabetic nephropathy., [RefSeq, PubMed]; Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "G5E8M1", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0030971 receptor tyrosine kinase binding;GO:0003712 transcription coregulator activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation;GO:0001946 lymphangiogenesis;GO:0046825 regulation of protein export from nucleus;GO:0035332 positive regulation of hippo signaling", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q62130-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RU80-1", "uniprot_id": [ { "id": "PTPRB_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RU80", "type": "external" } ], "mass": 224495.0, "length": 1998, "protein_name": "Receptor-type tyrosine-protein phosphatase beta", "gene_name": "Ptprb", "organism": "Mouse", "refseq_name": "receptor-type tyrosine-protein phosphatase beta isoform 1 precursor", "refseq_ac": [ { "id": "NP_084204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084204", "type": "external" } ], "gene_names_uniprotkb": "Ptprb", "gene_names_refseq": "3230402H02Rik; C130094E24; Ptprb; Ptpz; Rptpb; VE-PTP; Veptp", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase beta; 3.1.3.48; Protein-tyrosine phosphatase beta; R-PTP-beta; VE-PTP; Vascular endothelial protein tyrosine phosphatase", "protein_names_refseq": "R-PTP-beta; protein-tyrosine phosphatase beta; receptor-type tyrosine-protein phosphatase beta isoform 1 precursor; receptor-type tyrosine-protein phosphatase beta; vascular endothelial protein tyrosine phosphatase", "tax_id": 10090, "disease": "angiosarcoma (Disease Ontology:DOID:0001816); brain glioma (Disease Ontology:DOID:0060108); colorectal carcinoma (Disease Ontology:DOID:0080199); sarcoma (Disease Ontology:DOID:1115); glioblastoma (Disease Ontology:DOID:3068); osteosarcoma (Disease Ontology:DOID:3347); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); thyroid gland carcinoma (Disease Ontology:DOID:3963); breast angiosarcoma (Disease Ontology:DOID:4511); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:19263); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;10557082;11564762;12234928;16514057;17360632;19015309;19451274;20398064;21750661;25428506;26773517;30084848;34428180;34884741;35820727;36740996;38032480;39627609", "class_list": "", "function": "Heterogeneity of endothelial VE-PTP downstream polarization, Tie2 activation, junctional claudin-5, and permeability in the aorta and vena cava., [RefSeq, PubMed]; Plays an important role in blood vessel remodeling and angiogenesis (PubMed:26773517). Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin., [UniProtKB, UniProtKB]; Shear stress control of vascular leaks and atheromas through Tie2 activation by VE-PTP sequestration., [RefSeq, PubMed]; The Tyrosine Phosphatase hPTPRbeta Controls the Early Signals and Dopaminergic Cells Viability via the P2X7 Receptor. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 16, "predicted_n_glycosites": 15, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 10, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 10, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 10, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 12, "glyco_site_count": 26, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGZ7;Q8CIW2", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.3.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.78", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0045296 cadherin binding;GO:0004725 protein tyrosine phosphatase activity;GO:0030293 transmembrane receptor protein tyrosine kinase inhibitor activity", "go_cellular_component": "GO:0016020 membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0016311 dephosphorylation;GO:0001525 angiogenesis;GO:0001649 osteoblast differentiation;GO:0045668 negative regulation of osteoblast differentiation;GO:0008347 glial cell migration", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "B2RU80-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0P7-1", "uniprot_id": [ { "id": "PSRC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0P7", "type": "external" } ], "mass": 34707.0, "length": 329, "protein_name": "Proline/serine-rich coiled-coil protein 1", "gene_name": "Psrc1", "organism": "Mouse", "refseq_name": "proline/serine-rich coiled-coil protein 1", "refseq_ac": [ { "id": "NP_001177090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177090", "type": "external" } ], "gene_names_uniprotkb": "Psrc1; Dda3", "gene_names_refseq": "5430413I02Rik; Dda3; Psrc1", "protein_names_uniprotkb": "Proline/serine-rich coiled-coil protein 1", "protein_names_refseq": "differential display and activated by p53; p53-regulated DDA3; proline/serine-rich coiled-coil protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:56742)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10618717;12082536;12427559;17310996;21750661;35613310;35690006;36852467;36932468", "class_list": "", "function": "A p53 response element mediates transcriptional activation, [RefSeq, PubMed]; DDA3 is a novel microtubule-associated protein that binds to EB3, and results implicate DDA3 and EB3 in the beta-catenin-mediated growth signaling., [RefSeq, PubMed]; Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO production via manipulating gut microbiota and flavin monooxygenase 3., [RefSeq, PubMed]; Deficiency of proline/serine-rich coiled-coil protein 1 (PSRC1) accelerates trimethylamine N-oxide-induced atherosclerosis in ApoE(-/-) mice., [RefSeq, PubMed]; Molecular cloning, sequence analysis and gene expression, [RefSeq, PubMed]; Proline/serine-rich coiled-coil protein 1 inhibits macrophage inflammation and delays atherosclerotic progression by binding to Annexin A2., [RefSeq, PubMed]; Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8K4L8;Q9QXY5", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:0051301 cell division;GO:0045893 positive regulation of DNA-templated transcription;GO:0030308 negative regulation of cell growth;GO:0007080 mitotic metaphase chromosome alignment;GO:0031116 positive regulation of microtubule polymerization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9D0P7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35831-1", "uniprot_id": [ { "id": "PTN12_MOUSE", "url": "https://www.uniprot.org/uniprot/P35831", "type": "external" } ], "mass": 86526.0, "length": 775, "protein_name": "Tyrosine-protein phosphatase non-receptor type 12", "gene_name": "Ptpn12", "organism": "Mouse", "refseq_name": "tyrosine-protein phosphatase non-receptor type 12 isoform b", "refseq_ac": [ { "id": "NP_035333", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035333", "type": "external" } ], "gene_names_uniprotkb": "Ptpn12", "gene_names_refseq": "P19-PTP; PTP-P19; PTP-PEST; PTPG1; Ptpn12", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 12; 3.1.3.48; MPTP-PEST; P19-PTP; Protein-tyrosine phosphatase P19", "protein_names_refseq": "MPTP-PEST; protein-tyrosine phosphatase P19; tyrosine-protein phosphatase non-receptor type 12 isoform b; tyrosine-protein phosphatase non-receptor type 12", "tax_id": 10090, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:19248); (R-MMU-1250196); (R-MMU-182971); (R-MMU-186797); (R-MMU-8863795)", "pathway_count": 5, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10092676;11711533;12674328;1472029;15345747;15786712;1590786;17070019;17242355;19131326;19144319;21183079;21750661;25428506;28135057;28528544;32782141;36852467;7772023", "class_list": "", "function": "Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:17070019). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q80UM4", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0004721 phosphoprotein phosphatase activity;GO:0004726 non-membrane spanning protein tyrosine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0002102 podosome", "go_biological_process": "GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0006470 protein dephosphorylation;GO:0042246 tissue regeneration;GO:0071364 cellular response to epidermal growth factor stimulus;GO:0042058 regulation of epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P35831-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35295-1", "uniprot_id": [ { "id": "PURB_MOUSE", "url": "https://www.uniprot.org/uniprot/O35295", "type": "external" } ], "mass": 33901.0, "length": 324, "protein_name": "Transcriptional regulator protein Pur-beta", "gene_name": "Purb", "organism": "Mouse", "refseq_name": "transcriptional regulator protein Pur-beta", "refseq_ac": [ { "id": "NP_035351", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035351", "type": "external" } ], "gene_names_uniprotkb": "Purb", "gene_names_refseq": "2310015K15Rik; Cager-2; D11Bwg0414e; Purb", "protein_names_uniprotkb": "Transcriptional regulator protein Pur-beta; Purine-rich element-binding protein B; Vascular actin single-stranded DNA-binding factor 2 p44 component", "protein_names_refseq": "PurB beta; purine-rich single-stranded DNA-binding protein beta; transcriptional activator protein Pur-beta; transcriptional regulator protein Pur-beta; vascular actin single-stranded DNA-binding factor 2 p44 component", "tax_id": 10090, "disease": "", "pathway": " (mmu:19291)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10318844;11751932;12874279;16452087;17242355;17525332;18630941;19131326;19144319;21183079;23806337;24129315;27064749;31219806;31918924;33300544;33743134;36716953;37556352;9334258", "class_list": "", "function": "Aromatic Residues Dictate the Transcriptional Repressor and Single-Stranded DNA Binding Activities of Purine-Rich Element Binding Protein B., [RefSeq, PubMed]; Circ-calm4 regulates hypoxia-induced pulmonary artery smooth muscle autophagy by binding Purb., [RefSeq, PubMed]; Purbeta promotes hepatic glucose production by increasing Adcy6 transcription., [RefSeq, PubMed]; Transcriptional regulator which can act as an activator or a repressor (PubMed:11751932, PubMed:12874279, PubMed:27064749, PubMed:31918924, PubMed:33743134, PubMed:9334258). Represses the transcription of ACTA2 in fibroblasts and smooth muscle cells via its ability to interact with the purine-rich strand of a MCAT-containing element in the 5' flanking region of the gene (PubMed:11751932, PubMed:12874279, PubMed:27064749, PubMed:9334258). Represses the transcription of MYOCD, capable of repressing all isoforms of MYOCD but the magnitude of the repressive effects is most notable for the SMC-specific isoforms (PubMed:33743134). Promotes hepatic glucose production by activating the transcription of ADCY6, leading to cAMP accumulation, increased PKA activity, CREB activation, and increased transcription of PCK1 and G6PC genes (PubMed:31918924). Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene (By similarity). Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element (By similarity). Modulates constitutive liver galectin-3 gene transcription by binding to its promoter (By similarity). May play a role in the dendritic transport of a subset of mRNAs (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003700 DNA-binding transcription factor activity;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "O35295-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29351-1", "uniprot_id": [ { "id": "PTN6_MOUSE", "url": "https://www.uniprot.org/uniprot/P29351", "type": "external" } ], "mass": 67559.0, "length": 595, "protein_name": "Tyrosine-protein phosphatase non-receptor type 6", "gene_name": "Ptpn6", "organism": "Mouse", "refseq_name": "tyrosine-protein phosphatase non-receptor type 6 isoform b", "refseq_ac": [ { "id": "NP_001071173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071173", "type": "external" } ], "gene_names_uniprotkb": "Ptpn6; Hcph; Hcp; Ptp1C", "gene_names_refseq": "70Z-SHP; Hcph; PTPTY-42; Ptp1C; Ptpn6; SH-PTP1; SHP-1; hcp; me", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 6; 3.1.3.48; 70Z-SHP; Hematopoietic cell protein-tyrosine phosphatase; PTP-1C; PTPTY-42; Protein-tyrosine phosphatase 1C; SH-PTP1; SHP-1", "protein_names_refseq": "SH2 phosphatase 1; hematopoietic cell protein-tyrosine phosphatase; motheaten; protein-tyrosine phosphatase 1C; tyrosine-protein phosphatase non-receptor type 6 isoform b; tyrosine-protein phosphatase non-receptor type 6", "tax_id": 10090, "disease": "juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); Noonan syndrome 1 (Disease Ontology:DOID:0060578); anogenital venereal wart (Disease Ontology:DOID:11168); leukemia (Disease Ontology:DOID:1240); Noonan syndrome (Disease Ontology:DOID:3490); cervical cancer (Disease Ontology:DOID:4362)", "pathway": " (mmu:15170); (R-MMU-114604); (R-MMU-1433559); (R-MMU-201556); (R-MMU-210990); (R-MMU-389948); (R-MMU-432142); (R-MMU-512988); (R-MMU-5690714); (R-MMU-6798695); (R-MMU-877300); (R-MMU-912526); (R-MMU-912694); (R-MMU-983695); (R-MMU-9927353)", "pathway_count": 15, "publication_count": 47, "publication_id_list": "10.1101/2023.09.13.557529;10026201;10327049;10419485;1373816;1385421;14662855;1732748;17947660;18299400;19144319;19224205;1932742;19419305;19948503;20173027;20484733;20526344;21183079;21750661;21900501;21952136;22210881;23112346;23766558;25428506;25605945;26495903;27670070;28011936;29187734;29247647;30084848;30979083;31219806;33990399;34428180;38289832;38599809;39627609;8114715;8324828;9445485;9528781;9712903;9867848;9973385", "class_list": "", "function": "Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis. Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:9528781). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:10026201, PubMed:33990399). Modulates the signaling of several cytokine receptors including IL-4 receptor. Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling. Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; YTHDC1 inhibits osteoclast differentiation to alleviate osteoporosis by enhancing PTPN6 messenger RNA stability in an m6A-hUR-dependent manner., [RefSeq, PubMed]; [Effect of SHP-1 knockout in airway epithelial cells on emphysema phenotype in chronic obstructive pulmonary disease in mice]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35128;Q63872;Q63873;Q63874;Q921G3;Q9QVA6;Q9QVA7;Q9QVA8;Q9R0V6", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "1.4.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.22", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0001784 phosphotyrosine residue binding;GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0045577 regulation of B cell differentiation;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0002221 pattern recognition receptor signaling pathway;GO:0000278 mitotic cell cycle;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 5.2, "record_id": "P29351-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80U58-1", "uniprot_id": [ { "id": "PUM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80U58", "type": "external" } ], "mass": 114314.0, "length": 1066, "protein_name": "Pumilio homolog 2", "gene_name": "Pum2", "organism": "Mouse", "refseq_name": "pumilio homolog 2 isoform 1", "refseq_ac": [ { "id": "NP_001153691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153691", "type": "external" } ], "gene_names_uniprotkb": "Pum2; Kiaa0235", "gene_names_refseq": "5730503J23Rik; Pum2; Pumm2", "protein_names_uniprotkb": "Pumilio homolog 2", "protein_names_refseq": "pumilio 2; pumilio homolog 2 isoform 1; pumilio homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:80913)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11780640;12667987;18089289;19144319;19540345;19861488;21183079;21750661;25428506;29237092;30779550;31219806;32782141;32848054;34428180;36852467;37062520;37088847;37913857", "class_list": "", "function": "Downregulation of the RNA-binding protein PUM2 facilitates MSC-driven bone regeneration and prevents OVX-induced bone loss. Publication Status: Online-Only, [RefSeq, PubMed]; Norad Competently Binds with Pum2 to Regulate Neuronal Apoptosis and Play a Neuroprotective Role After SAH in Mice., [RefSeq, PubMed]; PUM2 regulates the formation of thoracic aortic dissection through EFEMP1., [RefSeq, PubMed]; Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation. Plays a role in cytoplasmic sensing of viral infection. Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm. May regulate DCUN1D3 mRNA levels. May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q80UZ9;Q91YW4;Q925A0;Q9ERC7", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0035198 miRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0106222 lncRNA binding;GO:0062104 pumilio-response element binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006417 regulation of translation;GO:0010629 negative regulation of gene expression;GO:0060612 adipose tissue development;GO:0010608 post-transcriptional regulation of gene expression;GO:0043488 regulation of mRNA stability", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q80U58-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80U78-1", "uniprot_id": [ { "id": "PUM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80U78", "type": "external" } ], "mass": 126619.0, "length": 1189, "protein_name": "Pumilio homolog 1", "gene_name": "Pum1", "organism": "Mouse", "refseq_name": "pumilio homolog 1 isoform 2", "refseq_ac": [ { "id": "NP_001153075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153075", "type": "external" } ], "gene_names_uniprotkb": "Pum1; Kiaa0099", "gene_names_refseq": "Pum1; Pumm; mKIAA0099", "protein_names_uniprotkb": "Pumilio homolog 1", "protein_names_refseq": "pumilio 1; pumilio homolog 1 isoform 2; pumilio homolog 1", "tax_id": 10090, "disease": "cerebellar ataxia type 47 (Disease Ontology:DOID:0111743)", "pathway": " (mmu:80912); (R-MMU-432722)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "12667987;17242355;19144319;21183079;21750661;22342750;22517741;22645316;24412312;25768905;29237092;29474920;30779550;32782141;32848054;34428180;34887587;35678316;36852467;37070548;39627609;40885482", "class_list": "", "function": "Dosage sensitivity to Pumilio1 variants in the mouse brain reflects distinct molecular mechanisms., [RefSeq, PubMed]; Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (By similarity). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (By similarity). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (By similarity). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53 (PubMed:22342750). Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (PubMed:24412312). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Sertoli cell PUMILIO proteins modulate mouse testis size through translational control of cell cycle regulators., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 10, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q80X96;Q80YU8;Q8BPV7;Q9EPU6", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0035198 miRNA binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon;GO:0000932 P-body", "go_biological_process": "GO:0006417 regulation of translation;GO:0007283 spermatogenesis;GO:0008344 adult locomotory behavior;GO:0048863 stem cell differentiation;GO:0010608 post-transcriptional regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q80U78-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BKG3-1", "uniprot_id": [ { "id": "PTK7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BKG3", "type": "external" } ], "mass": 117532.0, "length": 1062, "protein_name": "Inactive tyrosine-protein kinase 7", "gene_name": "Ptk7", "organism": "Mouse", "refseq_name": "inactive tyrosine-protein kinase 7 precursor", "refseq_ac": [ { "id": "NP_780377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780377", "type": "external" } ], "gene_names_uniprotkb": "Ptk7", "gene_names_refseq": "8430404F20Rik; Ptk7; chz; mPTK7/CCK4", "protein_names_uniprotkb": "Inactive tyrosine-protein kinase 7; Protein chuzhoi; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; Tyrosine-protein kinase-like 7", "protein_names_refseq": "inactive tyrosine-protein kinase 7 precursor; inactive tyrosine-protein kinase 7; protein chuzhoi; protein-tyrosine kinase 7; pseudo tyrosine kinase receptor 7; receptor tyrosine kinase-like protein; tyrosine-protein kinase-like 7", "tax_id": 10090, "disease": "scoliosis (Disease Ontology:DOID:0060249); idiopathic scoliosis (Disease Ontology:DOID:0060250)", "pathway": " (mmu:71461)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;15019986;15229603;19349973;19439496;19656770;20704721;21183079;30899004;34428180;36202326;36631445", "class_list": "", "function": "Inactive tyrosine kinase involved in the Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathways. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. Does not bind ATP (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Protein Tyrosine Kinase 7 (PTK7) Promotes Metastasis in Hepatocellular Carcinoma via SOX9 Regulation and TGF-beta Signaling., [RefSeq, PubMed]; Ptk7 mRNA was expressed at high levels in lung and un-pregnant uterus among adult tissues, and in the tail, limbs, somites, gut, and craniofacial regions among embryonic tissues, and suggest that PTK7 plays multiple roles in embryonic development., [RefSeq, PubMed]; Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 2, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q3V422;Q6W8S9;Q8CHK5;Q8K178", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007507 heart development;GO:0010976 positive regulation of neuron projection development;GO:0016477 cell migration;GO:0045198 establishment of epithelial cell apical/basal polarity", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q8BKG3-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91Z31-1", "uniprot_id": [ { "id": "PTBP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91Z31", "type": "external" } ], "mass": 57489.0, "length": 531, "protein_name": "Polypyrimidine tract-binding protein 2", "gene_name": "Ptbp2", "organism": "Mouse", "refseq_name": "polypyrimidine tract-binding protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001297640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297640", "type": "external" } ], "gene_names_uniprotkb": "Ptbp2; Brptb; Nptb", "gene_names_refseq": "Ptb2; Ptbp2; brPTB; nPTB", "protein_names_uniprotkb": "Polypyrimidine tract-binding protein 2; Brain-enriched PTB; Brain-enriched polypyrimidine tract-binding protein; Neural polypyrimidine tract-binding protein; RRM-type RNA-binding protein brPTB", "protein_names_refseq": "RRM-type RNA-binding protein brPTB; brain-enriched PTB; brain-enriched polypyrimidine tract-binding protein; neural polypyrimidine tract-binding protein; polypyrimidine tract-binding protein 2 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:56195)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10829067;11231079;11726525;12213192;14667811;15345747;21183079;21750661;22645316;30638744;31219806;32848054;34428180;35984892;38597390;40885482", "class_list": "", "function": "KIS counteracts PTBP2 and regulates alternative exon usage in neurons. Publication Status: Online-Only, [RefSeq, PubMed]; PTBP2 was identified as a brain-expressed protein that interacts with the paraneoplastic target antigen Nova1 by yeast 2-hybrid, in vivo co-IP and co-localization in neurons. Functionally, the proteins antagonize each other in splicing assays., [RefSeq, PubMed]; RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing (PubMed:10829067, PubMed:30638744). May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection (PubMed:10829067). In addition to its function in pre-mRNA splicing, also plays a role in the regulation of translation (PubMed:11726525)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNW7;Q9CUW2;Q9QYC2;Q9R0V9", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0030426 growth cone;GO:0043025 neuronal cell body;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0021510 spinal cord development;GO:0043484 regulation of RNA splicing;GO:0021549 cerebellum development;GO:0006376 mRNA splice site recognition;GO:0033119 negative regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q91Z31-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EST4-1", "uniprot_id": [ { "id": "PSMG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EST4", "type": "external" } ], "mass": 29524.0, "length": 264, "protein_name": "Proteasome assembly chaperone 2", "gene_name": "Psmg2", "organism": "Mouse", "refseq_name": "proteasome assembly chaperone 2 isoform 1", "refseq_ac": [ { "id": "NP_598899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598899", "type": "external" } ], "gene_names_uniprotkb": "Psmg2; Clast3; Tnfsf5ip1", "gene_names_refseq": "1700017I17Rik; Clast3; Pba2; Psmg2; Tnfsf5ip1", "protein_names_uniprotkb": "Proteasome assembly chaperone 2; CD40 ligand-activated specific transcript 3; Pba2; Proteasome chaperone homolog 2; Tumor necrosis factor superfamily member 5-induced protein 1", "protein_names_refseq": "CD40 ligand-activated specific transcript 3; proteasome assembly chaperone 2 isoform 1; proteasome assembly chaperone 2; proteasome chaperone homolog 2; tumor necrosis factor superfamily, member 5-induced protein 1", "tax_id": 10090, "disease": "proteosome-associated autoinflammatory syndrome 4 (Disease Ontology:DOID:0060915)", "pathway": " (mmu:107047); (R-MMU-9907900)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12147697;22645316;25428506;31219806;37507081", "class_list": "", "function": "Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TII5;Q3UXH7;Q8C1R5;Q91YJ0", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0101031 protein folding chaperone complex", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0043248 proteasome assembly;GO:0080129 proteasome core complex assembly;GO:0051131 chaperone-mediated protein complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9EST4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESK9-1", "uniprot_id": [ { "id": "RBCC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ESK9", "type": "external" } ], "mass": 182350.0, "length": 1588, "protein_name": "RB1-inducible coiled-coil protein 1", "gene_name": "Rb1cc1", "organism": "Mouse", "refseq_name": "RB1-inducible coiled-coil protein 1", "refseq_ac": [ { "id": "NP_033956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033956", "type": "external" } ], "gene_names_uniprotkb": "Rb1cc1; Cc1; Kiaa0203", "gene_names_refseq": "2900055E04Rik; 5930404L04Rik; Cc1; FIP200; LaXp180; Rb1cc1", "protein_names_uniprotkb": "RB1-inducible coiled-coil protein 1; Coiled-coil-forming protein 1; FAK family kinase-interacting protein of 200 kDa; FIP200; LaXp180", "protein_names_refseq": "200 kDa FAK family kinase-interacting protein; FAK family kinase-interacting protein of 200 kDa; RB1-inducible coiled-coil protein 1; coiled-coil-forming protein 1", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": " (mmu:12421); (R-MMU-1632852)", "pathway_count": 2, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;11207567;12095676;15375585;15968549;16452087;17242355;19258318;19940130;21088496;21183079;21525242;21750661;21795712;21807966;22645316;23262492;23285000;23392225;25428506;28561066;31219806;32782141;34418053;34428180;36852467;7724523", "class_list": "", "function": "Involved in autophagy (PubMed:19258318, PubMed:23262492). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:19258318, PubMed:23285000, PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (PubMed:21525242). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (PubMed:21807966). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (By similarity). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (PubMed:21795712). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:15968549). Plays a crucial role in muscular differentiation (PubMed:15968549). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (PubMed:19940130, PubMed:21088496)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways. Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway through induction of RB1 expression. Plays a crucial role in muscular differentiation. Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QLQ2;Q3TXX2;Q61384;Q8BRY9;Q9JK14", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0001889 liver development;GO:0001934 positive regulation of protein phosphorylation;GO:0006351 DNA-templated transcription;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q9ESK9-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TPD3-1", "uniprot_id": [ { "id": "ROBO2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TPD3", "type": "external" } ], "mass": 161190.0, "length": 1470, "protein_name": "Roundabout homolog 2", "gene_name": "Robo2", "organism": "Mouse", "refseq_name": "roundabout homolog 2 isoform 8 precursor", "refseq_ac": [ { "id": "NP_001401968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401968", "type": "external" } ], "gene_names_uniprotkb": "Robo2; Kiaa1568", "gene_names_refseq": "2600013A04Rik; 9430089E08Rik; D230004I22Rik; Robo2; mKIAA1568", "protein_names_uniprotkb": "Roundabout homolog 2", "protein_names_refseq": "roundabout homolog 2 isoform 8 precursor; roundabout homolog 2", "tax_id": 10090, "disease": "myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); transient cerebral ischemia (Disease Ontology:DOID:224); vesicoureteral reflux (Disease Ontology:DOID:9620)", "pathway": "", "pathway_count": 0, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;15091338;21183079;21750661;25428506;30899004;33300544", "class_list": "", "function": "Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 17, "disease_count": 3, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJ59", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008046 axon guidance receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030673 axolemma;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0006935 chemotaxis;GO:0016199 axon midline choice point recognition;GO:0007420 brain development;GO:0045747 positive regulation of Notch signaling pathway;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q7TPD3-1", "record_type": "protein", "filter_code": "0000000.1000110.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DIC0-1", "uniprot_id": [ { "id": "SMCA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6DIC0", "type": "external" } ], "mass": 180253.0, "length": 1577, "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2", "gene_name": "Smarca2", "organism": "Mouse", "refseq_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 isoform 3 precursor", "refseq_ac": [ { "id": "NP_001334368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334368", "type": "external" } ], "gene_names_uniprotkb": "Smarca2; Baf190b; Brm; Snf2a; Snf2l2", "gene_names_refseq": "2610209L14Rik; SAMRCA2; SNF2alpha; Smarca2; Snf2l2; brahma; brm", "protein_names_uniprotkb": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2; 3.6.4.-; BAF190B; BRG1-associated factor 190B; Probable global transcription activator SNF2L2; Protein brahma homolog; SAMRCA2; SNF2-alpha", "protein_names_refseq": "ATP-dependent helicase SMARCA2; BAF190B; BRG1-associated factor 190B; SNF2-alpha; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 isoform 3 precursor; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2; probable global transcription activator SNF2L2; protein brahma homolog; subunit of the SWI/SNF chromatin remodeling complex", "tax_id": 10090, "disease": "opportunistic bacterial infectious disease (Disease Ontology:DOID:0050340); Nicolaides-Baraitser syndrome (Disease Ontology:DOID:0081441); blepharophimosis-impaired intellectual development syndrome (Disease Ontology:DOID:0081442); prostate cancer (Disease Ontology:DOID:10283); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:67155); (R-MMU-3214858); (R-MMU-8939243); (R-MMU-9933937); (R-MMU-9933939); (R-MMU-9933947); (R-MMU-9934037)", "pathway_count": 7, "publication_count": 19, "publication_id_list": "15107404;17242355;17640523;18299400;19363039;20111005;21183079;21750661;22366787;22872234;22952240;23806337;26601204;31219806;34203471;34428180;36210013;36587526;36927987", "class_list": "", "function": "ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Chromatin remodeler BRM is a key mediator of leucine-stimulated mTOR gene transcription in mouse mammary epithelial cells., [RefSeq, PubMed]; The impact of SWI/SNF and NuRD inactivation on gene expression is tightly coupled with levels of RNA polymerase II occupancy at promoters., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.37", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0071564 npBAF complex;GO:0071565 nBAF complex", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:2000819 regulation of nucleotide-excision repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q6DIC0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1A8-1", "uniprot_id": [ { "id": "COP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1A8", "type": "external" } ], "mass": 80441.0, "length": 733, "protein_name": "E3 ubiquitin-protein ligase COP1", "gene_name": "Cop1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase COP1 isoform 1", "refseq_ac": [ { "id": "NP_036061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036061", "type": "external" } ], "gene_names_uniprotkb": "Cop1; RNF200; Rfwd2", "gene_names_refseq": "Cop1; Rfwd2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase COP1; 2.3.2.27; Constitutive photomorphogenesis protein 1 homolog; RING finger and WD repeat domain protein 2; RING-type E3 ubiquitin transferase RFWD2; mCOP1", "protein_names_refseq": "E3 ubiquitin-protein ligase COP1 isoform 1; E3 ubiquitin-protein ligase COP1; E3 ubiquitin-protein ligase RFWD2; RING finger and WD repeat domain protein 2; RING-type E3 ubiquitin transferase RFWD2; constitutive photomorphogenesis protein 1 homolog; constitutive photomorphogenic protein 1; mCOP1; ring finger and WD repeat domain 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:26374); (R-MMU-349425); (R-MMU-8951664)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10395541;16794074;18299400;20173027;21750661;25428506;31219806;34203471;34428180;34582788;35820727;36191790;37895214;40997131", "class_list": "", "function": "A CRISPR Screen Identifies the E3 Ubiquitin Ligase Rfwd2 as a Negative Regulator of Glucose Uptake in Brown Adipocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Description of a pathway in which Tribbles 3 (TRB3) stimulates lipolysis by triggering the degradation of acetyl-coenzyme A carboxylase (ACC) in adipose tissue; TRB3 promoted ACC ubiquitination through an association with the E3 ubiquitin ligase COP1, [RefSeq, PubMed]; E3 ubiquitin ligase COP1 confers neuroprotection in cerebral ischemia/reperfusion injury via regulation of transcription factor C/EBPbeta in microglia., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif., [UniProtKB, UniProtKB]; In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0000139 Golgi membrane;GO:0016607 nuclear speck", "go_biological_process": "GO:0045717 negative regulation of fatty acid biosynthetic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010212 response to ionizing radiation;GO:0016567 protein ubiquitination;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9R1A8-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UYI5-1", "uniprot_id": [ { "id": "RGL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UYI5", "type": "external" } ], "mass": 77945.0, "length": 709, "protein_name": "Ral guanine nucleotide dissociation stimulator-like 3", "gene_name": "Rgl3", "organism": "Mouse", "refseq_name": "ral guanine nucleotide dissociation stimulator-like 3", "refseq_ac": [ { "id": "NP_076111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076111", "type": "external" } ], "gene_names_uniprotkb": "Rgl3", "gene_names_refseq": "1300003D20Rik; Rgl3; mFLJ00153", "protein_names_uniprotkb": "Ral guanine nucleotide dissociation stimulator-like 3; RPM; RalGDS-like 3; RalGDS-related effector protein of M-Ras; Ras pathway modulator", "protein_names_refseq": "RPM; Ral guanine-nucleotide exchange factor; RalGDS-like protein 3; ral guanine nucleotide dissociation stimulator-like 3; ralGDS-like 3; ralGDS-related effector protein of M-Ras; ras pathway modulator", "tax_id": 10090, "disease": "", "pathway": " (mmu:71746); (R-MMU-5673001)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10869344;11313946;17242355;17382517;21183079;21750661", "class_list": "", "function": "Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1., [UniProtKB, PubMed, PubMed]; These findings raise the possibility that Rgl3 mediates interaction between Ras/Rap-family proteins and profilin II, an important activator of actin polymerization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6KAR7;Q8BKD3;Q924M8;Q9DBL8;Q9JID4", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007265 Ras protein signal transduction;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3UYI5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BSE0-1", "uniprot_id": [ { "id": "RMD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BSE0", "type": "external" } ], "mass": 47016.0, "length": 410, "protein_name": "Regulator of microtubule dynamics protein 2", "gene_name": "Rmdn2", "organism": "Mouse", "refseq_name": "regulator of microtubule dynamics protein 2 isoform 1", "refseq_ac": [ { "id": "NP_958749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958749", "type": "external" } ], "gene_names_uniprotkb": "Rmdn2; 4921513D11Rik; Fam82a1; Fam82a", "gene_names_refseq": "Fam82a1; RMD-2; Rmdn2; mRMD-2", "protein_names_uniprotkb": "Regulator of microtubule dynamics protein 2; Protein FAM82A1; RMD-2; mRMD-2", "protein_names_refseq": "family with sequence similarity 82, member A1; microtubule-associated protein; regulator of microtubule dynamics protein 2 isoform 1; regulator of microtubule dynamics protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:381110)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17242355;18070910;21183079;21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9UN02;Q8CIF1", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BSE0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q52KF3-1", "uniprot_id": [ { "id": "SPIR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q52KF3", "type": "external" } ], "mass": 68450.0, "length": 598, "protein_name": "Protein spire homolog 1", "gene_name": "Spire1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Spire1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein spire homolog 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 7, "publication_id_list": "15053972;21183079;21620703;21750661;21983562;31219806;34428180", "class_list": "", "function": "Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:21983562). Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage. In addition, promotes innate immune signaling downstream of dsRNA sensing. Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PDJ5;Q80V45", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005741 mitochondrial outer membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0015031 protein transport;GO:0030036 actin cytoskeleton organization;GO:0060996 dendritic spine development;GO:0001662 behavioral fear response;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q52KF3-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60973-1", "uniprot_id": [ { "id": "RBBP7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60973", "type": "external" } ], "mass": 47790.0, "length": 425, "protein_name": "Histone-binding protein RBBP7", "gene_name": "Rbbp7", "organism": "Mouse", "refseq_name": "histone-binding protein RBBP7", "refseq_ac": [ { "id": "NP_033057", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033057", "type": "external" } ], "gene_names_uniprotkb": "Rbbp7; Rbap46", "gene_names_refseq": "Rbbp7; mRbAp46", "protein_names_uniprotkb": "Histone-binding protein RBBP7; Histone acetyltransferase type B subunit 2; Nucleosome-remodeling factor subunit RBAP46; RBBP-7; Retinoblastoma-binding protein 7; Retinoblastoma-binding protein p46", "protein_names_refseq": "G1/S transition control protein-binding protein; RBBP-7; histone acetyltransferase type B subunit 2; histone-binding protein RBBP7; nucleosome-remodeling factor subunit RBAP46; retinoblastoma-binding protein 7; retinoblastoma-binding protein p46", "tax_id": 10090, "disease": "X-linked spermatogenic failure 9 (Disease Ontology:DOID:0061177); azoospermia (Disease Ontology:DOID:14227)", "pathway": " (mmu:245688); (R-MMU-212300); (R-MMU-2559580); (R-MMU-3214815); (R-MMU-3214841); (R-MMU-3214847); (R-MMU-3214858); (R-MMU-606279); (R-MMU-6804758); (R-MMU-73762); (R-MMU-8943724); (R-MMU-8951664); (R-MMU-8953750); (R-MMU-9764725); (R-MMU-9909649); (R-MMU-9937850); (R-MMU-9940951)", "pathway_count": 17, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;10984530;11788710;20144788;21540332;21606357;21750661;23806337;25153642;25428506;27806305;30084848;30779550;34180153;34203471;34428180;35820727;37843278;38994637;40997131;7503932", "class_list": "", "function": "Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex (By similarity)., [UniProtKB, UniProtKB]; Unveiling the role of circRBBP7 in myoblast proliferation and differentiation: A novel regulator of muscle development., [RefSeq, PubMed]; X-linked RBBP7 mutation causes maturation arrest and testicular tumors. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AFJ0;Q3UX20", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0035098 ESC/E(Z) complex;GO:0016589 NURF complex", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q60973-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08943-1", "uniprot_id": [ { "id": "SSRP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08943", "type": "external" } ], "mass": 80860.0, "length": 708, "protein_name": "FACT complex subunit SSRP1", "gene_name": "Ssrp1", "organism": "Mouse", "refseq_name": "FACT complex subunit SSRP1", "refseq_ac": [ { "id": "NP_001129553", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129553", "type": "external" } ], "gene_names_uniprotkb": "Ssrp1", "gene_names_refseq": "Hmg1-rs1; Hmgi-rs3; Hmgox; Ssrp1; T160", "protein_names_uniprotkb": "FACT complex subunit SSRP1; Facilitates chromatin transcription complex subunit SSRP1; Recombination signal sequence recognition protein 1; Structure-specific recognition protein 1; T160", "protein_names_refseq": "FACT complex subunit SSRP1; facilitates chromatin transcription complex subunit SSRP1; recombination signal sequence recognition protein 1", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:20833); (R-MMU-112382); (R-MMU-674695); (R-MMU-6796648); (R-MMU-6804756); (R-MMU-75955)", "pathway_count": 6, "publication_count": 21, "publication_id_list": "12861016;1678855;17242355;19131326;19144319;21183079;21750661;23364797;23806337;25428506;25605945;30084848;30779550;31219806;32894293;34428180;36210013;36511897;38072046;39627609;40885482", "class_list": "", "function": "Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Histone chaperone FACT represses retrotransposon MERVL and MERVL-derived cryptic promoters., [RefSeq, PubMed]; Mir204 and Mir211 suppress synovial inflammation and proliferation in rheumatoid arthritis by targeting Ssrp1. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional regulation of FACT involves Coordination of chromatin accessibility and CTCF binding., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U9Z2;Q3UJ75;Q4V9U4;Q8CGA6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0042393 histone binding;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0035101 FACT complex;GO:0005694 chromosome", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006260 DNA replication;GO:0006334 nucleosome assembly;GO:0006337 nucleosome disassembly", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q08943-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWY7-1", "uniprot_id": [ { "id": "S39AB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWY7", "type": "external" } ], "mass": 35466.0, "length": 342, "protein_name": "Zinc transporter ZIP11", "gene_name": "Slc39a11", "organism": "Mouse", "refseq_name": "zinc transporter ZIP11 isoform 1", "refseq_ac": [ { "id": "NP_001159975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159975", "type": "external" } ], "gene_names_uniprotkb": "Slc39a11; Zip11", "gene_names_refseq": "1810074D23Rik; Slc39a11; ZIP-11", "protein_names_uniprotkb": "Zinc transporter ZIP11; Solute carrier family 39 member 11; ZIP-11; Zrt- and Irt-like protein 11", "protein_names_refseq": "solute carrier family 39 member 11; zinc transporter ZIP11 isoform 1; zinc transporter ZIP11; zrt- and Irt-like protein 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:69806)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21702047;21750661;23643525;24089422;31219806;34428180", "class_list": "", "function": "Data suggest that Zip11 has unique protein sequence and structure features, it functions as a cellular zinc transporter, and its expression is at least partially regulated by zinc via hMTF-1 binding to metal response element sequences of Zip11 promoter., [RefSeq, PubMed]; Zinc importer that regulates cytosolic zinc concentration either via zinc influx from the extracellular compartment or efflux from intracellular organelles such as Golgi apparatus. May transport copper ions as well. The transport mechanism remains to be elucidated., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZ08;Q8K0E0;Q8VE72;Q99KI2;Q9D8J0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0005375 copper ion transmembrane transporter activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0071578 zinc ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BWY7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51450-1", "uniprot_id": [ { "id": "RORG_MOUSE", "url": "https://www.uniprot.org/uniprot/P51450", "type": "external" } ], "mass": 58117.0, "length": 516, "protein_name": "Nuclear receptor ROR-gamma", "gene_name": "Rorc", "organism": "Mouse", "refseq_name": "nuclear receptor ROR-gamma isoform 2", "refseq_ac": [ { "id": "NP_001280663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001280663", "type": "external" } ], "gene_names_uniprotkb": "Rorc; Nr1f3; Rorg; Thor", "gene_names_refseq": "Nr1f3; RORgamma; Rorc; TOR; Thor", "protein_names_uniprotkb": "Nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; Retinoid-related orphan receptor-gamma; TOR; Thymus orphan receptor", "protein_names_refseq": "RAR-related orphan receptor C; nuclear receptor ROR-gamma isoform 2; nuclear receptor ROR-gamma; nuclear receptor RZR-gamma; nuclear receptor subfamily 1 group F member 3; retinoid-related orphan receptor-gamma; thymus orphan receptor", "tax_id": 10090, "disease": "immunodeficiency 42 (Disease Ontology:DOID:0111940); Sjogren's syndrome (Disease Ontology:DOID:12894); tuberculosis (Disease Ontology:DOID:399)", "pathway": " (mmu:19885); (R-MMU-383280)", "pathway_count": 2, "publication_count": 34, "publication_id_list": "10602018;14691482;16148126;16990136;17476214;17666523;18164222;18368049;19381306;19965867;21499262;21750661;21853531;22170608;22753030;22789990;23562159;23723244;25212631;26607793;30084848;34428180;35831503;36070798;36071167;36071169;40021952;40185101;40228524;40298935;8614404;8973331;9403063;9881970", "class_list": "", "function": "Nuclear receptor essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes and Peyer's patches (PubMed:10602018, PubMed:14691482, PubMed:16148126, PubMed:9881970). Required for the generation of LTi (lymphoid tissue inducer) cells (PubMed:14691482). Regulates thymocyte survival through DNA-binding on ROREs of target gene promoter regions and recruitment of coactivaros via the AF-2 (PubMed:16148126). Also plays a key role, downstream of IL6 and TGFB and synergistically with RORA, for lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program (PubMed:16990136, PubMed:18164222, PubMed:26607793). Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus (PubMed:16990136, PubMed:18164222, PubMed:26607793). Plays a key role in tolerance to gut microbiota and foreign antigens in food by mediating differentiation of peripherally-induced regulatory T-cells (pTreg), which suppress inflammatory responses to commensal microorganisms and food proteins (PubMed:36070798, PubMed:36071167, PubMed:36071169, PubMed:40185101, PubMed:40298935). Specifically expressed in antigen-presenting cell populations, such as (1) type 3 innate lymphoid cells (ILC3s), which are required for tolerance to gut microbiota, (2) Thetis cells, also named Janus cells, which are enriched in gut lymph nodes during early life and are required for oral tolerance, and (3) a subset of dendritic cells (PubMed:36070798, PubMed:36071167, PubMed:36071169, PubMed:40185101, PubMed:40298935). Following activation by an unknown ligand in antigen-presenting cells, promotes recruitment of transcription regulators, such as PRDM16 or ZBTB46, and drives differentiation of pTreg cells, which maintain immune tolerance and prevent autoimmune diseases (PubMed:35831503, PubMed:40228524). May also play a role in the pre-TCR activation cascade leading to the maturation of alpha/beta T-cells and may participate in the regulation of DNA accessibility in the TCR-J(alpha) locus (PubMed:10602018)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts (PubMed:17666523, PubMed:19381306, PubMed:19965867, PubMed:21853531, PubMed:22789990, PubMed:23723244). Regulates the circadian expression of clock genes such as CRY1, BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner (PubMed:22753030). Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock (PubMed:22753030). Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A. Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1 (PubMed:21853531). Also plays a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC1 and PCK1. Regulates the rhythmic expression of PROX1 and promotes its nuclear localization. Plays an indispensable role in the induction of IFN-gamma dependent anti-mycobacterial systemic immunity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9Q8I1;Q3U513;Q61027;Q91YT5;Q9QXD9;Q9R177", "ec_number_list": [], "go_molecular_function": "GO:0008142 oxysterol binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0009897 external side of plasma membrane;GO:0016604 nuclear body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P51450-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q922D4-1", "uniprot_id": [ { "id": "PP6R3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q922D4", "type": "external" } ], "mass": 94653.0, "length": 844, "protein_name": "Serine/threonine-protein phosphatase 6 regulatory subunit 3", "gene_name": "Ppp6r3", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 3", "refseq_ac": [ { "id": "NP_001157631", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157631", "type": "external" } ], "gene_names_uniprotkb": "Ppp6r3; D19Ertd703e; Kiaa1558; Pp6r3; Saps3", "gene_names_refseq": "4930528G08Rik; 9130026N02Rik; D19Bwg1430e; D19Ertd703e; Pp6r3; Ppcs3; Ppp6r3; Pptcs3; Sapl; Saps3; mKIAA1558", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 6 regulatory subunit 3; SAPS domain family member 3", "protein_names_refseq": "SAPS domain family, member 3; pluripotent cell-specific 3; serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 3; serine/threonine-protein phosphatase 6 regulatory subunit 3; sporulation-induced transcript 4-associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:52036); (R-MMU-171319); (R-MMU-204005)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "15345747;16769727;17242355;18630941;21183079;21750661;25428506;28135057;28528544;33725478;34428180;34887587;36914647;39627609", "class_list": "", "function": "Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance (By similarity)., [UniProtKB]; SAPS3 subunit of protein phosphatase 6 is an AMPK inhibitor and controls metabolic homeostasis upon dietary challenge in male mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPM9;Q8BTW6;Q9D2X9", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q922D4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXK9-1", "uniprot_id": [ { "id": "RBM33_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXK9", "type": "external" } ], "mass": 137325.0, "length": 1231, "protein_name": "RNA-binding protein 33", "gene_name": "Rbm33", "organism": "Mouse", "refseq_name": "RNA-binding protein 33", "refseq_ac": [ { "id": "NP_082510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082510", "type": "external" } ], "gene_names_uniprotkb": "Rbm33; Prr8", "gene_names_refseq": "3200001K10Rik; 6430512A10Rik; Prr8; Rbm33", "protein_names_uniprotkb": "RNA-binding protein 33; Proline-rich protein 8; RNA-binding motif protein 33", "protein_names_refseq": "RNA-binding protein 33; proline rich 8; proline-rich protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:381626)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.3389/fragi.2021.757801;19144319;21183079;21750661;24129315;30059200;31219806;34418053;34428180;35822049;40997131", "class_list": "", "function": "RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation. Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery. Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5. Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5Z3;Q8C5J6", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0030674 protein-macromolecule adaptor activity;GO:1990247 N6-methyladenosine-containing RNA reader activity;GO:0106222 lncRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043488 regulation of mRNA stability;GO:0061157 mRNA destabilization;GO:0051028 mRNA transport;GO:0006405 RNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9CXK9-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60710-1", "uniprot_id": [ { "id": "SAMH1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60710", "type": "external" } ], "mass": 75893.0, "length": 658, "protein_name": "Deoxynucleoside triphosphate triphosphohydrolase SAMHD1", "gene_name": "Samhd1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Samhd1; Mg21", "gene_names_refseq": "", "protein_names_uniprotkb": "Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; 3.1.5.-; Interferon-gamma-inducible protein Mg11; SAM domain and HD domain-containing protein 1; dNTPase; mSAMHD1", "protein_names_refseq": "", "tax_id": 10090, "disease": "Aicardi-Goutieres syndrome (Disease Ontology:DOID:0050629); Chilblain lupus (Disease Ontology:DOID:0060386); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:56045); (R-MMU-8956319)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "17242355;19131326;19525956;21183079;21750661;22645316;23872947;23972988;24788674;25153642;26495903;26580513;26667483;27920203;28135057;28528544;29125738;29187734;29379009;29669924;31548683;34428180;37828378;39627609;7884320", "class_list": "", "function": "Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (By similarity). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells (PubMed:23872947, PubMed:23972988, PubMed:26667483, PubMed:29379009, PubMed:31548683). Likewise, suppresses LINE-1 retrotransposon activity (PubMed:26667483). In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools (By similarity). Phosphorylation at Thr-634 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks (By similarity). Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication (By similarity). Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation (By similarity). Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (By similarity). Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (PubMed:29669924)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q0K6;F8WJE0;Q3U5X2;Q543A4;Q91VK8", "ec_number_list": [ { "id": "3.1.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.5.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005525 GTP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0097197 tetraspanin-enriched microdomain;GO:0035861 site of double-strand break", "go_biological_process": "GO:0045087 innate immune response;GO:0051289 protein homotetramerization;GO:0051607 defense response to virus;GO:0006203 dGTP catabolic process;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q60710-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PE13-1", "uniprot_id": [ { "id": "PRRT3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PE13", "type": "external" } ], "mass": 101224.0, "length": 971, "protein_name": "Proline-rich transmembrane protein 3", "gene_name": "Prrt3", "organism": "Mouse", "refseq_name": "proline-rich transmembrane protein 3 isoform a precursor", "refseq_ac": [ { "id": "NP_001276629", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276629", "type": "external" } ], "gene_names_uniprotkb": "Prrt3", "gene_names_refseq": "6330505P20; B230206N24Rik; Prrt3", "protein_names_uniprotkb": "Proline-rich transmembrane protein 3", "protein_names_refseq": "proline-rich transmembrane protein 3 isoform a precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:210673)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;17114649;21183079;21750661;24129315;31219806;33300544;34203471;35820727", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q6PE13-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES07-1", "uniprot_id": [ { "id": "S15A2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ES07", "type": "external" } ], "mass": 81632.0, "length": 729, "protein_name": "Solute carrier family 15 member 2", "gene_name": "Slc15a2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc15a2; Pept2", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 15 member 2; Kidney H(+)/peptide cotransporter; Oligopeptide transporter, kidney isoform; Peptide transporter 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;11027540;21183079;21750661;29784761;34428180", "class_list": "", "function": "Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:11027540). Transports neutral and anionic dipeptides with a proton to peptide stoichiometry of 2:1 or 3:1 (By similarity). In kidney, involved in the absorption of circulating di- and tripeptides from the glomerular filtrate. Can also transport beta-lactam antibiotics, such as the aminocephalosporin cefadroxil, and other antiviral and anticancer drugs (By similarity). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Also able to transport carnosine (By similarity). Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs) (PubMed:29784761). Mediates transport of bacterial peptidoglycans across the plasma membrane or, in macrophages, the phagosome membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (PubMed:29784761)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9536, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015333 peptide:proton symporter activity;GO:0015334 high-affinity oligopeptide transmembrane transporter activity;GO:0042937 tripeptide transmembrane transporter activity;GO:0071916 dipeptide transmembrane transporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016324 apical plasma membrane;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:0015031 protein transport;GO:0070293 renal absorption;GO:0006857 oligopeptide transport;GO:0140206 dipeptide import across plasma membrane;GO:0070424 regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9ES07-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80U16-1", "uniprot_id": [ { "id": "RIPR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80U16", "type": "external" } ], "mass": 118970.0, "length": 1078, "protein_name": "Rho family-interacting cell polarization regulator 2", "gene_name": "Ripor2", "organism": "Mouse", "refseq_name": "rho family-interacting cell polarization regulator 2 isoform 2", "refseq_ac": [ { "id": "NP_001073850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073850", "type": "external" } ], "gene_names_uniprotkb": "Ripor2; Fam65b; Kiaa0386", "gene_names_refseq": "Fam65b; Ripor2", "protein_names_uniprotkb": "Rho family-interacting cell polarization regulator 2", "protein_names_refseq": "family with sequence similarity 65, member B; protein FAM65B; rho family-interacting cell polarization regulator 2 isoform 2", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 104 (Disease Ontology:DOID:0110465); autosomal dominant nonsyndromic deafness 21 (Disease Ontology:DOID:0110551)", "pathway": " (mmu:193385)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "17150207;20173027;21183079;21750661;24687993;24958875;25428507;25588844;26495903;27269051;28011936;30254631;30280293;30349076;31218594;31219806;32631815;34428180;36113482", "class_list": "", "function": "Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:25588844, PubMed:27269051). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (PubMed:17150207). Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (By similarity). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (PubMed:25588844). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (PubMed:27269051). Plays a role for maintaining the structural organization of the basal domain of stereocilia (PubMed:27269051). Involved in mechanosensory hair cell function (PubMed:27269051). Required for normal hearing (PubMed:27269051)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Dysferlin deficiency seems to significantly alter the gene expression of Fam65b and Hdac6 during regeneration, since higher levels of expression of both genes were observed in dysferlin-deficient mice., [RefSeq, PubMed]; RIPOR2-mediated autophagy dysfunction is critical for aminoglycoside-induced hearing loss., [RefSeq, PubMed]; Results show that Fam65b expression and phosphorylation can finely tune the amount of active RhoA in order to favor optimal T lymphocyte motility. Publication Status: Online-Only, [RefSeq, PubMed]; The FAM65B is a downstream target of Pink1 and Pink1 phosphorylates FAM65B at serine 46. Phosphorylated FAM65B inhibits autophagy and cell death in the heart., [RefSeq, PubMed]; We propose that Ripor2 deficiency influences abundance and/or post-translational modifications of proteins expressed in both stereocilia and kinocilia. This effect may have a negative impact on the structure and function of the auditory hair cell bundle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6PW01;A6PW03;Q3TQ58;Q5SY29;Q5SZV4;Q5T0J1;Q8BIM7;Q8BJ19;Q8BJ22;Q8BJ32;Q8BJ54", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0071889 14-3-3 protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0016324 apical plasma membrane;GO:0030175 filopodium", "go_biological_process": "GO:1990869 cellular response to chemokine;GO:0006935 chemotaxis;GO:0007155 cell adhesion;GO:0007162 negative regulation of cell adhesion;GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q80U16-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R143-1", "uniprot_id": [ { "id": "PTTG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R143", "type": "external" } ], "mass": 19965.0, "length": 174, "protein_name": "Pituitary tumor-transforming gene 1 protein-interacting protein", "gene_name": "Pttg1ip", "organism": "Mouse", "refseq_name": "pituitary tumor-transforming gene 1 protein-interacting protein precursor", "refseq_ac": [ { "id": "NP_666037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666037", "type": "external" } ], "gene_names_uniprotkb": "Pttg1ip", "gene_names_refseq": "1810010L20Rik; PBF; Pttg1ip", "protein_names_uniprotkb": "Pituitary tumor-transforming gene 1 protein-interacting protein; PBF; PTTG-binding factor; Pituitary tumor-transforming gene protein-binding factor", "protein_names_refseq": "PTTG-binding factor; pituitary tumor-transforming gene 1 protein-interacting protein precursor; pituitary tumor-transforming gene 1 protein-interacting protein; pituitary tumor-transforming gene protein-binding factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:108705)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;19131326;21750661;24506068;34428180", "class_list": "", "function": "May facilitate PTTG1 nuclear translocation., [UniProtKB]; Protooncogene PBF is a negative regulator of p53 function in thyroid tumorigenesis, in which PBF is generally overexpressed and p53 mutations are rare compared with other tumor types, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVT1;Q8BJ96;Q8N7P0", "ec_number_list": [], "go_molecular_function": "GO:0002039 p53 binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0031398 positive regulation of protein ubiquitination;GO:0045732 positive regulation of protein catabolic process;GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator;GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8R143-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSI3-1", "uniprot_id": [ { "id": "PP6R1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TSI3", "type": "external" } ], "mass": 94527.0, "length": 856, "protein_name": "Serine/threonine-protein phosphatase 6 regulatory subunit 1", "gene_name": "Ppp6r1", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 6 regulatory subunit 1", "refseq_ac": [ { "id": "NP_766482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766482", "type": "external" } ], "gene_names_uniprotkb": "Ppp6r1; Kiaa1115; Pp6r1; Saps1", "gene_names_refseq": "2010309P17Rik; B430201G11Rik; D030074N20Rik; Pp6r1; Ppp6r1; Saps1; mKIAA1115", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 6 regulatory subunit 1; SAPS domain family member 1", "protein_names_refseq": "SAPS domain family, member 1; serine/threonine-protein phosphatase 6 regulatory subunit 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:243819); (R-MMU-204005)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "16769727;17242355;21183079;21750661;31219806;31751917;33300544;34428180;39627609;40885482", "class_list": "", "function": "Deletion of the SAPS1 subunit of protein phosphatase 6 in mice increases radiosensitivity and impairs the cellular DNA damage response., [RefSeq, PubMed]; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80TJ4", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity;GO:0031267 small GTPase binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0030027 lamellipodium", "go_biological_process": "GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q7TSI3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YQ5-1", "uniprot_id": [ { "id": "RPN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YQ5", "type": "external" } ], "mass": 68528.0, "length": 608, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1", "gene_name": "Rpn1", "organism": "Mouse", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor", "refseq_ac": [ { "id": "NP_598694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598694", "type": "external" } ], "gene_names_uniprotkb": "Rpn1", "gene_names_refseq": "D6Wsu137e; Rpn-1; Rpn1", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit; RPN-I; Ribophorin I; Ribophorin-1", "protein_names_refseq": "RPN-I; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; ribophorin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:103963); (R-MMU-9768727); (R-MMU-9931295)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;21750661;23806337;25428506;25605945;26740625;28011936;30084848;30899004;31219806;32783947;34428180;34887587;36288343;37453647;37507081;37828378", "class_list": "glycogene", "function": "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 40, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3U985", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005791 rough endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0008250 oligosaccharyltransferase complex", "go_biological_process": "GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q91YQ5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000001000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XPI3-1", "uniprot_id": [ { "id": "RN123_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5XPI3", "type": "external" } ], "mass": 148652.0, "length": 1314, "protein_name": "E3 ubiquitin-protein ligase RNF123", "gene_name": "Rnf123", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF123 isoform 1", "refseq_ac": [ { "id": "NP_001298081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298081", "type": "external" } ], "gene_names_uniprotkb": "Rnf123; Kpc1", "gene_names_refseq": "Kpc1; Rnf123", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF123; 2.3.2.27; Kip1 ubiquitination-promoting complex protein 1; RING finger protein 123", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF123 isoform 1; E3 ubiquitin-protein ligase RNF123; RING-type E3 ubiquitin transferase RNF123; kip1 ubiquitination-promoting complex protein 1; ubiquitin ligase", "tax_id": 10090, "disease": "", "pathway": " (mmu:84585); (R-MMU-5689880); (R-MMU-983168)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;15531880;21750661;22645316;24129315;25428506;30084848;33973242;34428180;35063657", "class_list": "glycogene", "function": "Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome-mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B: acts by catalyzing ubiquitination of the NFKB1 p105 precursor, leading to limited proteasomal degradation of NFKB1 p105 and generation of the active NFKB1 p50 subunit. Functions also as an inhibitor of innate antiviral signaling mediated by RIGI and IFIH1 independently of its E3 ligase activity. Interacts with the N-terminal CARD domains of RIGI and IFIH1 and competes with the downstream adapter MAVS., [UniProtKB, UniProtKB]; Dysregulation of Rnf 213 gene contributes to T cell response via antigen uptake, processing, and presentation., [RefSeq, PubMed]; E3 ubiquitin ligase RNF123-deficient mice exhibit reduced parasitemia and mortality in rodent malaria (Plasmodium yoelii 17XL) infection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 66, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6PGE0", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0007249 canonical NF-kappaB signal transduction;GO:0051604 protein maturation;GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q5XPI3-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61085-1", "uniprot_id": [ { "id": "RHPN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61085", "type": "external" } ], "mass": 71319.0, "length": 643, "protein_name": "Rhophilin-1", "gene_name": "Rhpn1", "organism": "Mouse", "refseq_name": "rhophilin-1 isoform 2", "refseq_ac": [ { "id": "NP_032190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032190", "type": "external" } ], "gene_names_uniprotkb": "Rhpn1; Grbp", "gene_names_refseq": "Grbp; Rhophilin; Rhpn1; mKIAA1929", "protein_names_uniprotkb": "Rhophilin-1; GTP-Rho-binding protein 1", "protein_names_refseq": "GTP-Rho-binding protein 1; GTP-rho binding protein 1; rhophilin-1 isoform 2; rhophilin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14787); (R-MMU-5666185); (R-MMU-8980692)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10591629;21183079;21750661;25071083;8571126", "class_list": "", "function": "Essential for the integrity of the glomerular filtration barrier and a key determinant of podocyte cytoskeleton architecture, [RefSeq, PubMed]; Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QMX9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0007165 signal transduction;GO:0001822 kidney development;GO:0048041 focal adhesion assembly;GO:0003094 glomerular filtration;GO:0051497 negative regulation of stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q61085-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80U57-1", "uniprot_id": [ { "id": "RIMS3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80U57", "type": "external" } ], "mass": 32589.0, "length": 307, "protein_name": "Regulating synaptic membrane exocytosis protein 3", "gene_name": "Rims3", "organism": "Mouse", "refseq_name": "regulating synaptic membrane exocytosis protein 3", "refseq_ac": [ { "id": "NP_891559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_891559", "type": "external" } ], "gene_names_uniprotkb": "Rims3; Kiaa0237", "gene_names_refseq": "A730060M23Rik; Nim3; Rim3; Rims3; mKIAA0237", "protein_names_uniprotkb": "Regulating synaptic membrane exocytosis protein 3; Nim3; RIM 3; RIM3 gamma; Rab-3-interacting molecule 3", "protein_names_refseq": "RIM3 gamma; rab-3-interacting molecule 3; regulating synaptic membrane exocytosis protein 3", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:242662)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12620390;17114649;20485683;21183079;26142343", "class_list": "", "function": "Mouse RIM3 proteins carrying amino acid substitutions that correspond to mutations associated with autism (E176A and M259V) modify RIM3 interaction with VDCC beta-subunits, [RefSeq, PubMed]; Regulates synaptic membrane exocytosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone;GO:0044325 transmembrane transporter binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0042734 presynaptic membrane;GO:0099524 postsynaptic cytosol", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0017156 calcium-ion regulated exocytosis;GO:0050807 regulation of synapse organization;GO:0016082 synaptic vesicle priming;GO:0016081 synaptic vesicle docking", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80U57-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8E6-1", "uniprot_id": [ { "id": "RL4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8E6", "type": "external" } ], "mass": 47154.0, "length": 419, "protein_name": "Large ribosomal subunit protein uL4", "gene_name": "Rpl4", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL4", "refseq_ac": [ { "id": "NP_077174", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077174", "type": "external" } ], "gene_names_uniprotkb": "Rpl4", "gene_names_refseq": "2010004J23Rik; Rpl4", "protein_names_uniprotkb": "Large ribosomal subunit protein uL4; 60S ribosomal protein L4", "protein_names_refseq": "60S ribosomal protein L4; large ribosomal subunit protein uL4", "tax_id": 10090, "disease": "", "pathway": " (mmu:67891); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 32, "publication_id_list": "10.1101/2023.09.13.557529;11823430;18299400;19131326;19224205;20173027;20484733;21952136;23806337;24129315;24463520;25428506;25605945;28011936;28315936;30084848;30779550;31219806;33300544;33649389;33725478;34428180;35820727;35984892;36210013;36288343;36517592;37453647;37507081;37828378;39627609;39927985", "class_list": "glycogene", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 28, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9CY08", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008097 5S rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005791 rough endoplasmic reticulum", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation;GO:0140236 translation at presynapse", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "Q9D8E6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQZ7-1", "uniprot_id": [ { "id": "RIMS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQZ7", "type": "external" } ], "mass": 172863.0, "length": 1530, "protein_name": "Regulating synaptic membrane exocytosis protein 2", "gene_name": "Rims2", "organism": "Mouse", "refseq_name": "regulating synaptic membrane exocytosis protein 2 isoform d", "refseq_ac": [ { "id": "NP_001243313", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243313", "type": "external" } ], "gene_names_uniprotkb": "Rims2; Rab3ip2; Rim2", "gene_names_refseq": "2810036I15Rik; RIM2; Rab3ip2; Rim2(+40A); Rim2(+44A); Rim2(+4A); Rims2; Serg2; Syt3-rs; mKIAA0751", "protein_names_uniprotkb": "Regulating synaptic membrane exocytosis protein 2; RIM 2; Rab-3-interacting molecule 2; Rab-3-interacting protein 2", "protein_names_refseq": "RIM 2; Rab3 interacting protein 1; Rab3 interacting protein 2; rab-3-interacting protein 2; rab3-interacting protein 2; regulating synaptic membrane exocytosis protein 2 isoform d; regulating synaptic membrane exocytosis protein 2; synaptic exocytosis regulator 2; synaptotagmin 3, related sequence", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:116838)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;11056535;12401793;12578829;12620390;16452087;19458039;21183079;21750661;22517741;32848054;34428180;35822049;38012808;38218585;40021952;40885482", "class_list": "", "function": "Gene knockout of RNA binding motif 5 in the brain alters RIMS2 protein homeostasis in the cerebellum and Hippocampus and exacerbates behavioral deficits after a TBI in mice., [RefSeq, PubMed]; N6-methyladenosine-modified circRIMS2 mediates synaptic and memory impairments by activating GluN2B ubiquitination in Alzheimer's disease. Publication Status: Online-Only, [RefSeq, PubMed]; Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q8C433;Q8CCK2", "ec_number_list": [], "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0043005 neuron projection;GO:0042734 presynaptic membrane", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0006886 intracellular protein transport;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation;GO:0042391 regulation of membrane potential", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q9EQZ7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z205-1", "uniprot_id": [ { "id": "RFXK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z205", "type": "external" } ], "mass": 29232.0, "length": 269, "protein_name": "DNA-binding protein RFXANK", "gene_name": "Rfxank", "organism": "Mouse", "refseq_name": "DNA-binding protein RFXANK isoform 2", "refseq_ac": [ { "id": "NP_001020760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020760", "type": "external" } ], "gene_names_uniprotkb": "Rfxank; Rfxb; Tvl1", "gene_names_refseq": "Rfxank; Tvl1", "protein_names_uniprotkb": "DNA-binding protein RFXANK; Ankyrin repeat-containing adapter protein Tvl-1; RFX-B; Regulatory factor X subunit B; Regulatory factor X-associated ankyrin-containing protein", "protein_names_refseq": "DNA-binding protein RFXANK isoform 2; DNA-binding protein RFXANK; RFX-B; ankyrin repeat-containing adapter protein Tvl-1; regulatory factor X subunit B", "tax_id": 10090, "disease": "severe combined immunodeficiency (Disease Ontology:DOID:627)", "pathway": " (mmu:19727)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10329666;15964851;16236793;9806546", "class_list": "", "function": "ANKRA, RFXANK, and CIITA are novel targets of class IIa HDACs which may deacetylases play a role in regulating MHCII expression, [RefSeq, PubMed]; Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters (By similarity). May also potentiate the activation of RAF1 (PubMed:10329666)., [UniProtKB, UniProtKB, PubMed]; Class II histone deacetylases (HDACs)4 and HDAC5 interact with the ankyrin repeats of ankyrin repeat, family A and RFXANK and, through association with RFXANK, repress MHC II promoter activation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042826 histone deacetylase binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045171 intercellular bridge", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9Z205-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1J3-1", "uniprot_id": [ { "id": "SARNP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1J3", "type": "external" } ], "mass": 23533.0, "length": 210, "protein_name": "SAP domain-containing ribonucleoprotein", "gene_name": "Sarnp", "organism": "Mouse", "refseq_name": "SAP domain-containing ribonucleoprotein isoform 1", "refseq_ac": [ { "id": "NP_079640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079640", "type": "external" } ], "gene_names_uniprotkb": "Sarnp; Hcc1", "gene_names_refseq": "1110005A23Rik; Cip29; Sarnp", "protein_names_uniprotkb": "SAP domain-containing ribonucleoprotein; Nuclear protein Hcc-1", "protein_names_refseq": "SAP domain-containing ribonucleoprotein isoform 1; nuclear protein Hcc-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66118); (R-MMU-159236); (R-MMU-72187)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;23806337;26192747;32782141;32848054;34428180;34678516;35984892;36852467;40885482", "class_list": "", "function": "Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJZ4;Q9CU18", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0000346 transcription export complex", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006406 mRNA export from nucleus;GO:0006417 regulation of translation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9D1J3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LB7-1", "uniprot_id": [ { "id": "SARDH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LB7", "type": "external" } ], "mass": 101682.0, "length": 919, "protein_name": "Sarcosine dehydrogenase, mitochondrial", "gene_name": "Sardh", "organism": "Mouse", "refseq_name": "sarcosine dehydrogenase, mitochondrial", "refseq_ac": [ { "id": "NP_619606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619606", "type": "external" } ], "gene_names_uniprotkb": "Sardh", "gene_names_refseq": "Sardh", "protein_names_uniprotkb": "Sarcosine dehydrogenase, mitochondrial; 1.5.8.3; SarDH", "protein_names_refseq": "sarcosine dehydrogenase, mitochondrial", "tax_id": 10090, "disease": "sarcosinemia (Disease Ontology:DOID:0112307); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:192166); (R-MMU-6798163)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;23576753;23806337;30084848;34428180;37453647", "class_list": "", "function": "Catalyzes the last step of the oxidative degradation of choline to glycine. Converts sarcosine into glycine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.5.8.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.8.3", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0005542 folic acid binding;GO:0008480 sarcosine dehydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006545 glycine biosynthetic process;GO:0042426 choline catabolic process;GO:1901053 sarcosine catabolic process;GO:0035999 tetrahydrofolate interconversion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99LB7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99P65-1", "uniprot_id": [ { "id": "S29A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99P65", "type": "external" } ], "mass": 51719.0, "length": 475, "protein_name": "Equilibrative nucleoside transporter 3", "gene_name": "Slc29a3", "organism": "Mouse", "refseq_name": "equilibrative nucleoside transporter 3", "refseq_ac": [ { "id": "NP_076085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076085", "type": "external" } ], "gene_names_uniprotkb": "Slc29a3; Ent3", "gene_names_refseq": "4933435C21Rik; Ent3; Slc29a3", "protein_names_uniprotkb": "Equilibrative nucleoside transporter 3; Solute carrier family 29 member 3; mENT3", "protein_names_refseq": "equilibrative nucleoside transporter 3; mENT3; solute carrier family 29 member 3", "tax_id": 10090, "disease": "histiocytosis-lymphadenopathy plus syndrome (Disease Ontology:DOID:0111278)", "pathway": " (mmu:71279); (R-MMU-83936); (R-MMU-9755088)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "11396612;15701636;19144319;20140240;21750661;22174130;26495903;28011936;33725478;34428180;37462944;38925413", "class_list": "", "function": "Broad selectivity, low affinity nucleoside transporter that can also transport adenine, [RefSeq, PubMed]; Equilibrative nucleoside transporter 3 supports microglial functions and protects against the progression of Huntington's disease in the mouse model. Erratum:[Brain Behav Immun. 2024 Oct;121:403. doi: 10.1016/j.bbi.2024.08.018. PMID: 39155153], [RefSeq, PubMed]; Mutation analysis of candidate genes within the target interval identified biallelic germline mutations in SLC29A3 in the Faisalabad histiocytosis kindred and in two families reported to have familial Rosai-Dorfman disease. Publication Status: Online-Only, [RefSeq, PubMed]; TLR7/8 stress response drives histiocytosis in SLC29A3 disorders., [RefSeq, PubMed]; Uniporter that mediates the facilitative transport of nucleoside across lysosomal and mitochondrial membranes (PubMed:15701636, PubMed:22174130). Functions as a non-electrogenic Na(+)-independent transporter (PubMed:15701636). Transport activity is pH-dependent and enhanced under acidic conditions, consistent with localization to acidic intracellular compartments (PubMed:15701636). Protons are not cotransported but likely modulate transport by altering the ionization state of the transporter which dictates its conformation, thereby regulating substrate permeability (By similarity). May direct the nucleoside transport from lysosomes to cytosol or cytosol to mitochondria to facilitate nucleic acid salvage pathways (PubMed:22174130). Transports nucleosides (adenosine, guanosine, uridine, thymidine, cytidine and inosine), deoxynucleosides (deoxyadenosine, deoxycytidine), purine nucleobases (adenine, guanine) and pyrimidine nucleobases (uracil) (PubMed:15701636, PubMed:22174130). Also capable of transporting monoamine neurotransmitters dopamine, serotonin, noradrenaline and tyramine, as well as ATP (By similarity). Mediates nucleoside export from lysosomes in macrophages, thereby regulating macrophage function and number (PubMed:22174130). Also functions as a lysosomal urate exporter, contributing to intracellular urate disposal. Regulates inflammasome activation via dual roles in urate and adenosine transport (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RQD3", "ec_number_list": [], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015205 nucleobase transmembrane transporter activity;GO:0015212 cytidine transmembrane transporter activity;GO:0015213 uridine transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0015851 nucleobase transport;GO:0015861 cytidine transport;GO:0015858 nucleoside transport;GO:0015862 uridine transmembrane transport;GO:0015872 dopamine transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99P65-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17563-1", "uniprot_id": [ { "id": "SBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P17563", "type": "external" } ], "mass": 52514.0, "length": 472, "protein_name": "Methanethiol oxidase", "gene_name": "Selenbp1", "organism": "Mouse", "refseq_name": "methanethiol oxidase", "refseq_ac": [ { "id": "NP_033176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033176", "type": "external" } ], "gene_names_uniprotkb": "Selenbp1; Lpsb", "gene_names_refseq": "Lp56; Lpsb; MTO; SBP56; Selenbp1", "protein_names_uniprotkb": "Methanethiol oxidase; 1.8.3.4; 56 kDa selenium-binding protein; MTO; SBP56; SP56; Selenium-binding protein 1", "protein_names_refseq": "56 kDa selenium-binding protein; SP56; methanethiol oxidase", "tax_id": 10090, "disease": "glaucoma (Disease Ontology:DOID:1686)", "pathway": " (mmu:20341)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15378723;21750661;2225343;29255262;30084848;31019652;31616917;34069420;34428180;37453647;37507081;37801218", "class_list": "", "function": "Ablation of Selenbp1 Alters Lipid Metabolism via the Pparalpha Pathway in Mouse Kidney. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (PubMed:29255262). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Knocking out Selenium Binding Protein 1 Induces Depressive-Like Behavior in Mice., [RefSeq, PubMed]; Oxidative stress-induced DNA methylation of miR-122 aggravates colitis targeting SELENBP1 partially by p65NF-kappaB signaling and may promote the progression of Crohn's disease. Erratum:[Oxid Med Cell Longev. 2026 Feb 25;2026:9789842. doi: 10.1155/omcl/9789842. PMID: 41757227] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91X87", "ec_number_list": [ { "id": "1.8.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.4", "type": "external" } ], "go_molecular_function": "GO:0008430 selenium binding;GO:0018549 methanethiol oxidase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016020 membrane;GO:0001650 fibrillar center;GO:0005634 nucleus", "go_biological_process": "GO:0015031 protein transport;GO:0050873 brown fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P17563-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2B0-1", "uniprot_id": [ { "id": "SC65_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2B0", "type": "external" } ], "mass": 51132.0, "length": 443, "protein_name": "Endoplasmic reticulum protein SC65", "gene_name": "P3h4", "organism": "Mouse", "refseq_name": "endoplasmic reticulum protein SC65 isoform 2 precursor", "refseq_ac": [ { "id": "NP_789800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789800", "type": "external" } ], "gene_names_uniprotkb": "P3h4; Leprel4; Sc65", "gene_names_refseq": "1110036O03Rik; Leprel4; P3h4; Sc65", "protein_names_uniprotkb": "Endoplasmic reticulum protein SC65; Leprecan-like protein 4; Prolyl 3-hydroxylase family member 4; Synaptonemal complex protein SC65", "protein_names_refseq": "SC65 synaptonemal complex protein (Sc65-pending); endoplasmic reticulum protein SC65 isoform 2 precursor; endoplasmic reticulum protein SC65; leprecan-like 4; leprecan-like protein 4; synaptonemal complex protein SC65", "tax_id": 10090, "disease": "", "pathway": " (mmu:66180)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;23959653;27119146;28115524;30899004;34428180", "class_list": "", "function": "Both P3h3- and Sc65-null mice displayed a similar pattern of severe under-hydroxylation of lysines, particularly at cross-linking sites in type I collagen from bone, skin, dentin, cornea, and aorta, revealing a complex evolution and interplay between the proteins forming the machinery of collagen prolyl 3-hydroxylation and lysyl hydroxylation in the ER, [RefSeq, PubMed]; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils (PubMed:27119146). Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly (PubMed:23959653, PubMed:27119146, PubMed:28115524)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:1902494 catalytic complex;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0046849 bone remodeling;GO:0032964 collagen biosynthetic process;GO:0017185 peptidyl-lysine hydroxylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8K2B0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80UG5-1", "uniprot_id": [ { "id": "SEPT9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80UG5", "type": "external" } ], "mass": 65575.0, "length": 583, "protein_name": "Septin-9", "gene_name": "Septin9", "organism": "Mouse", "refseq_name": "septin-9 isoform a", "refseq_ac": [ { "id": "NP_001106958", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106958", "type": "external" } ], "gene_names_uniprotkb": "Septin9; Kiaa0991; Sept9; Sint1", "gene_names_refseq": "MSF1; Msf; PNUTL4; Sept9; Septin9; Sint1", "protein_names_uniprotkb": "Septin-9; SL3-3 integration site 1 protein", "protein_names_refseq": "MLL septin-like fusion; SL3-3 integration site 1 protein; septin-9 isoform a", "tax_id": 10090, "disease": "brachial plexus neuritis (Disease Ontology:DOID:3689); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:53860)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;10666245;12039034;17242355;17546647;21183079;21750661;22645316;23806337;25153642;25428506;25605945;28135057;28528544;30779550;32848054;34428180;35820727;36354207;38906977;40885482", "class_list": "", "function": "Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)., [UniProtKB]; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis., [UniProtKB, UniProtKB]; MiR-503-5p alleviates peripheral neuropathy-induced neuropathic pain in T2DM mice by regulating SEPT9 to inhibit astrocyte activation. Publication Status: Online-Only, [RefSeq, PubMed]; Septin 9 controls CCNB1 stabilization via APC/C[CDC20] during meiotic metaphase I/anaphase I transition in mouse oocytes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A2A6U2;A2A6U4;A2A6U6;Q3URP2;Q80TM7;Q9QYX9", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005940 septin ring;GO:0005874 microtubule;GO:0005929 cilium;GO:0015629 actin cytoskeleton;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization;GO:0008104 intracellular protein localization;GO:0032185 septin cytoskeleton organization;GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q80UG5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFT2-1", "uniprot_id": [ { "id": "SET1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CFT2", "type": "external" } ], "mass": 215352.0, "length": 1985, "protein_name": "Histone-lysine N-methyltransferase SETD1B", "gene_name": "Setd1b", "organism": "Mouse", "refseq_name": "histone-lysine N-methyltransferase SETD1B", "refseq_ac": [ { "id": "NP_001035488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035488", "type": "external" } ], "gene_names_uniprotkb": "Setd1b; Kiaa1076; Set1b", "gene_names_refseq": "KMT2G; Setd1b; mKIAA1076", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SETD1B; 2.1.1.364; SET domain-containing protein 1B", "protein_names_refseq": "SET domain-containing protein 1B; histone-lysine N-methyltransferase SETD1B", "tax_id": 10090, "disease": "neurodevelopmental disorder with speech impairment and dysmorphic facies (Disease Ontology:DOID:0070417)", "pathway": " (mmu:208043); (R-MMU-3214841); (R-MMU-8936459); (R-MMU-9772755)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "17242355;17355966;21183079;21750661;24550110;25428506;25605945;29916805;30084848;30779550;31219806;34678516;34806773;35445296", "class_list": "", "function": "Expression of the histone lysine methyltransferases SETD1B, SETDB1, SETD2, and CFP1 exhibits significant changes in the oocytes and granulosa cells of aged mouse ovaries., [RefSeq, PubMed]; Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (By similarity). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (PubMed:29916805)., [UniProtKB, UniProtKB, PubMed]; Postnatal expression of the lysine methyltransferase SETD1B is essential for learning and the regulation of neuron-enriched genes., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q80TK9;Q8CFQ8;Q8CGD1", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.366", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.366", "type": "external" }, { "id": "2.1.1.370", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.370", "type": "external" }, { "id": "2.1.1.371", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.371", "type": "external" }, { "id": "2.1.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.85", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0042800 histone H3K4 methyltransferase activity;GO:0140945 histone H3K4 monomethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8CFT2-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0K2-1", "uniprot_id": [ { "id": "SCOT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0K2", "type": "external" } ], "mass": 55989.0, "length": 520, "protein_name": "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial", "gene_name": "Oxct1", "organism": "Mouse", "refseq_name": "succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_077150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077150", "type": "external" } ], "gene_names_uniprotkb": "Oxct1; Oxct; Scot", "gene_names_refseq": "2610008O03Rik; Oxct1; Oxct2a; Oxct; SCOT; Scot-s", "protein_names_uniprotkb": "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; 2.8.3.5; 3-oxoacid CoA-transferase 1; SCOT-s; SCOT; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase; Succinyl-CoA:3-oxoacid CoA transferase", "protein_names_refseq": "somatic-type succinyl-CoA:3-oxoacid CoA-transferase; succinyl-CoA:3-ketoacid CoA transferase; succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial precursor; succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; succinyl-CoA:3-oxoacid CoA transferase", "tax_id": 10090, "disease": "carbohydrate metabolic disorder (Disease Ontology:DOID:2978); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:67041); (R-MMU-77108); (R-MMU-9837999)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "12534938;21209089;23806337;25428506;30084848;32750298;33300544;35820727;36288343;38042218;38199308;39927985;40684658", "class_list": "", "function": "Although Oxct1(-/-) mice exhibit normal prenatal development, all develop ketoacidosis, hypoglycemia, and reduced plasma lactate concentrations within the first 48 h of birth, [RefSeq, PubMed]; Identifying Acss1, Mtfp1 and Oxct1 as key regulators and promising biomarkers of sarcopenia in various models., [RefSeq, PubMed]; Key enzyme for ketone body catabolism. Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate), and produces acetoacetyl-CoA. Acetoacetyl-CoA is further metabolized by acetoacetyl-CoA thiolase into two acetyl-CoA molecules which enter the citric acid cycle for energy production (By similarity). Forms a dimeric enzyme where both of the subunits are able to form enzyme-CoA thiolester intermediates, but only one subunit is competent to transfer the CoA moiety to the acceptor (3-oxo acid) carboxylate and produce a new acyl-CoA. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; OXCT1 regulates hippocampal neurogenesis and alleviates cognitive impairment via the Akt/GSK-3beta/beta-catenin pathway after subarachnoid hemorrhage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIW6;Q9CV92", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008260 succinyl-CoA:3-oxo-acid CoA-transferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0007507 heart development;GO:0007584 response to nutrient;GO:0042594 response to starvation;GO:0045471 response to ethanol;GO:0060612 adipose tissue development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9D0K2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQI7-1", "uniprot_id": [ { "id": "RU2B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQI7", "type": "external" } ], "mass": 25323.0, "length": 225, "protein_name": "U2 small nuclear ribonucleoprotein B''", "gene_name": "Snrpb2", "organism": "Mouse", "refseq_name": "U2 small nuclear ribonucleoprotein B''", "refseq_ac": [ { "id": "NP_067310", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067310", "type": "external" } ], "gene_names_uniprotkb": "Snrpb2", "gene_names_refseq": "2810052G09Rik; Snrpb2", "protein_names_uniprotkb": "U2 small nuclear ribonucleoprotein B''; U2 snRNP B''", "protein_names_refseq": "U2 small nuclear ribonucleoprotein B''; U2 snRNP B''", "tax_id": 10090, "disease": "disease of cellular proliferation (Disease Ontology:DOID:14566); germ cell cancer (Disease Ontology:DOID:2994); connective tissue disease (Disease Ontology:DOID:65)", "pathway": " (mmu:20639)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;23806337;29187734;37507081", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CW35;Q9CZ66", "ec_number_list": [], "go_molecular_function": "GO:0070990 snRNP binding;GO:0030619 U1 snRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0001650 fibrillar center;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CQI7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BIV7-1", "uniprot_id": [ { "id": "S45A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BIV7", "type": "external" } ], "mass": 81474.0, "length": 751, "protein_name": "Proton-associated sugar transporter A", "gene_name": "Slc45a1", "organism": "Mouse", "refseq_name": "proton-associated sugar transporter A isoform 1", "refseq_ac": [ { "id": "NP_776135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776135", "type": "external" } ], "gene_names_uniprotkb": "Slc45a1; Dnb5", "gene_names_refseq": "C230078B22; Dnb5; PAST-A; Slc45a1", "protein_names_uniprotkb": "Proton-associated sugar transporter A; DNb-5 homolog; Deleted in neuroblastoma 5 protein homolog; PAST-A; Solute carrier family 45 member 1", "protein_names_refseq": "DNb-5 homolog; deleted in neuroblastoma 5 protein homolog; proton-associated sugar transporter A isoform 1; proton-associated sugar transporter A", "tax_id": 10090, "disease": "", "pathway": " (mmu:242773)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21750661;30779550;36210013;41576950", "class_list": "", "function": "Neuron-specific proton-associated hexose transporter, which mediates hexose efflux from lysosomes (PubMed:41576950). Hexose efflux is required for the stability of the vacuolar ATPase (V-ATPase) complex on the lysosomal membrane (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZ98", "ec_number_list": [], "go_molecular_function": "GO:0008506 sucrose:proton symporter activity;GO:0005356 D-glucose:proton symporter activity;GO:0015517 galactose:proton symporter activity;GO:0005351 carbohydrate:proton symporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:1904659 D-glucose transmembrane transport;GO:0015757 galactose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BIV7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q505G4-1", "uniprot_id": [ { "id": "RTL6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q505G4", "type": "external" } ], "mass": 26660.0, "length": 243, "protein_name": "Retrotransposon Gag-like protein 6", "gene_name": "Rtl6", "organism": "Mouse", "refseq_name": "retrotransposon Gag-like protein 6", "refseq_ac": [ { "id": "NP_808298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808298", "type": "external" } ], "gene_names_uniprotkb": "Rtl6; Ldoc1l; Mar6; Mart6; Sushi-15E3", "gene_names_refseq": "Ldoc1l; Mar6; Mart6; Rtl6", "protein_names_uniprotkb": "Retrotransposon Gag-like protein 6; Mammalian retrotransposon-derived protein 6; Protein LDOC1L; Protein Sushi-15E3", "protein_names_refseq": "gag-like protein; leucine zipper, down-regulated in cancer 1-like; mammalian retrotransposon-derived protein 6; protein LDOC1L; retrotransposon Gag-like protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:223732)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15716091;16093683;16155747", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNE4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q505G4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I012-1", "uniprot_id": [ { "id": "S38AA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5I012", "type": "external" } ], "mass": 117194.0, "length": 1090, "protein_name": "Solute carrier family 38 member 10", "gene_name": "Slc38a10", "organism": "Mouse", "refseq_name": "solute carrier family 38 member 10 isoform 2", "refseq_ac": [ { "id": "NP_001158270", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158270", "type": "external" } ], "gene_names_uniprotkb": "Slc38a10", "gene_names_refseq": "1810073N04Rik; Slc38a10", "protein_names_uniprotkb": "Solute carrier family 38 member 10; Amino acid transporter SLC38A10", "protein_names_refseq": "amino acid transporter SLC38A10; novel amino acid transporter protein; putative sodium-coupled neutral amino acid transporter 10; solute carrier family 38 member 10 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72055)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "21183079;21750661;25428506;25605945;27802388;28593130;30084848;30779550;34428180;35450293;37107593", "class_list": "", "function": "Facilitates bidirectional transport of amino acids. May act as a glutamate sensor that regulates glutamate-glutamine cycle and mTOR signaling in the brain. The transport mechanism remains to be elucidated., [UniProtKB, PubMed, PubMed]; SLC38A10 Deficiency in Mice Affects Plasma Levels of Threonine and Histidine in Males but Not in Females: A Preliminary Characterization Study of SLC38A10[-/-] Mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AMZ5;Q3TVW4;Q641M1;Q80ZZ4;Q8C1Y0;Q8CCR5;Q9D8J3", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0060348 bone development;GO:0003333 amino acid transmembrane transport;GO:0006865 amino acid transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q5I012-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DID3-1", "uniprot_id": [ { "id": "SCAF8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6DID3", "type": "external" } ], "mass": 139572.0, "length": 1268, "protein_name": "SR-related and CTD-associated factor 8", "gene_name": "Scaf8", "organism": "Mouse", "refseq_name": "SR-related and CTD-associated factor 8", "refseq_ac": [ { "id": "NP_598884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598884", "type": "external" } ], "gene_names_uniprotkb": "Scaf8; Kiaa1116; Rbm16", "gene_names_refseq": "A630086M08Rik; A930036P18Rik; Rbm16; Scaf8; mKIAA1116", "protein_names_uniprotkb": "SR-related and CTD-associated factor 8; RNA-binding motif protein 16", "protein_names_refseq": "CTD-binding SR-like protein rA8; RNA binding motif protein 16; SR-like CTD-associated factor 8; SR-related and CTD-associated factor 8; protein SCAF8; putative RNA-binding protein 16", "tax_id": 10090, "disease": "syndrome (Disease Ontology:DOID:225)", "pathway": " (mmu:106583)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "21183079;21750661;22872234;24129315;25428506;30084848;30779550;34428180;34887587;36852467;40885482;40997131;8692929;9528809", "class_list": "", "function": "Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF4, also acts as a positive regulator of transcript elongation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTX6;Q5U5V8;Q80TJ3;Q8C037", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0019904 protein domain specific binding;GO:0000993 RNA polymerase II complex binding;GO:0070063 RNA polymerase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016363 nuclear matrix;GO:0005849 mRNA cleavage factor complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0006366 transcription by RNA polymerase II;GO:0006369 termination of RNA polymerase II transcription;GO:0032786 positive regulation of DNA-templated transcription, elongation;GO:2000805 negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q6DID3-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2C2-1", "uniprot_id": [ { "id": "SAAL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2C2", "type": "external" } ], "mass": 52769.0, "length": 474, "protein_name": "Protein SAAL1", "gene_name": "Saal1", "organism": "Mouse", "refseq_name": "protein SAAL1 isoform 1", "refseq_ac": [ { "id": "NP_084509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084509", "type": "external" } ], "gene_names_uniprotkb": "Saal1", "gene_names_refseq": "5031425D22Rik; SPACIA1; Saal1", "protein_names_uniprotkb": "Protein SAAL1; SPACIA1; Synoviocyte proliferation-associated in collagen-induced arthritis protein 1", "protein_names_refseq": "protein SAAL1 isoform 1; protein SAAL1; synoviocyte proliferation-associated in collagen-induced arthritis 1; synoviocyte proliferation-associated in collagen-induced arthritis protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:78935)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15345747;17525332;21183079;22127701;25428506;30084848;30779550", "class_list": "", "function": "Overexpression of SPACIA1/SAAL1, a newly identified gene that is involved in synoviocyte proliferation, accelerates the progression of synovitis in mice and humans., [RefSeq, PubMed]; Plays a role in promoting the proliferation of synovial fibroblasts in response to pro-inflammatory stimuli., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UYS6;Q8R2L2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:1901647 positive regulation of synoviocyte proliferation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D2C2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P69566-1", "uniprot_id": [ { "id": "RANB9_MOUSE", "url": "https://www.uniprot.org/uniprot/P69566", "type": "external" } ], "mass": 71012.0, "length": 653, "protein_name": "Ran-binding protein 9", "gene_name": "Ranbp9", "organism": "Mouse", "refseq_name": "ran-binding protein 9 isoform 1", "refseq_ac": [ { "id": "NP_064314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064314", "type": "external" } ], "gene_names_uniprotkb": "Ranbp9; Ranbpm", "gene_names_refseq": "IBAP-1; Ibap1; RanBPM; Ranbp9", "protein_names_uniprotkb": "Ran-binding protein 9; B-cell antigen receptor Ig beta-associated protein 1; IBAP-1; Ran-binding protein M; RanBP9; RanBPM", "protein_names_refseq": "B cell antigen receptor Ig beta associated protein 1; ran-binding protein 9 isoform 1; ran-binding protein 9; ran-binding protein M", "tax_id": 10090, "disease": "", "pathway": " (mmu:56705); (R-MMU-373760); (R-MMU-5673001); (R-MMU-8851805); (R-MMU-9861718)", "pathway_count": 5, "publication_count": 18, "publication_id_list": "12084015;12963025;14648869;14722085;18710924;19224205;20173027;21183079;21750661;22872234;25428506;28254886;29126923;31219806;32346083;32680981;34428180;35820727", "class_list": "", "function": "Lipopolysaccharide-Induced Acute Lung Injury Is Associated with Increased Ran-Binding Protein in Microtubule-Organizing Center (RanBPM) Molecule Expression and Mitochondria-Mediated Apoptosis Signaling Pathway in a Mouse Model. Publication Status: Online-Only, [RefSeq, PubMed]; May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways. Acts as a mediator of cell spreading and actin cytoskeleton rearrangement. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA., [UniProtKB, UniProtKB]; RanBPM is the enzymic substrate for USP11 and is deubiquitinated specifically, [RefSeq, PubMed]; Results showed that RANBP9 is involved in alternative splicing by interacting with CLOCK during murine spermatogenesis., [RefSeq, PubMed]; Tagging enhances histochemical and biochemical detection of Ran Binding Protein 9 in vivo and reveals its interaction with Nucleolin. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P84500;Q3V136", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0030674 protein-macromolecule adaptor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007010 cytoskeleton organization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:1902993 positive regulation of amyloid precursor protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P69566-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C567-1", "uniprot_id": [ { "id": "NCTR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C567", "type": "external" } ], "mass": 37266.0, "length": 325, "protein_name": "Natural cytotoxicity triggering receptor 1", "gene_name": "Ncr1", "organism": "Mouse", "refseq_name": "natural cytotoxicity triggering receptor 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_034876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034876", "type": "external" } ], "gene_names_uniprotkb": "Ncr1; Ly94", "gene_names_refseq": "Cd335; Ly94; NKp46; Ncr1", "protein_names_uniprotkb": "Natural cytotoxicity triggering receptor 1; Activating receptor 1; Lymphocyte antigen 94; NK-p46; NKp46; Natural killer cell p46-related protein; mAR-1; mNKp46", "protein_names_refseq": "MAR1 (mouse activating receptor 1); NK-p46; activating receptor 1; lymphocyte antigen 94; mAR-1; mNKp46; natural cytotoxicity triggering receptor 1 isoform 1 precursor; natural killer cell p46-related protein", "tax_id": 10090, "disease": "lymphoproliferative syndrome (Disease Ontology:DOID:0060704); anogenital venereal wart (Disease Ontology:DOID:11168); hepatitis C (Disease Ontology:DOID:1883); acquired immunodeficiency syndrome (Disease Ontology:DOID:635)", "pathway": " (mmu:17086)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10092106;14504081;17360655;21750661;34428180", "class_list": "", "function": "Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis., [UniProtKB]; Mouse NKp46 triggers Natural Killer cell effector function and allows the detection of NK cells in situ., [RefSeq, PubMed]; NKp46 interacts with both viral hemagglutinins and the unknown tumor ligands via different mechanisms., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q1RLN4;Q80UY6;Q9Z0Q4", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0140375 immune receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway;GO:0051607 defense response to virus;GO:0009597 detection of virus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8C567-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41438-1", "uniprot_id": [ { "id": "S19A1_MOUSE", "url": "https://www.uniprot.org/uniprot/P41438", "type": "external" } ], "mass": 58150.0, "length": 512, "protein_name": "Reduced folate transporter", "gene_name": "Slc19a1", "organism": "Mouse", "refseq_name": "reduced folate transporter isoform a", "refseq_ac": [ { "id": "NP_001186200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186200", "type": "external" } ], "gene_names_uniprotkb": "Slc19a1", "gene_names_refseq": "RFC-1; RFC1; RFC; Slc19a1", "protein_names_uniprotkb": "Reduced folate transporter; IFC-1; Intestinal folate carrier 1; Plasma membrane folate antiporter SLC19A1; RFC-1; RFC1; Reduced folate carrier 1; Solute carrier family 19 member 1", "protein_names_refseq": "IFC-1; folate transporter 1; intestinal folate carrier 1; intestinal folate carrier protein; plasma membrane folate antiporter SLC19A1; reduced folate carrier 1; reduced folate transporter isoform a; reduced folate transporter; solute carrier family 19 (sodium/hydrogen exchanger), member 1; solute carrier family 19 member 1", "tax_id": 10090, "disease": "biotin-responsive basal ganglia disease (Disease Ontology:DOID:0050659); dextro-looped transposition of the great arteries (Disease Ontology:DOID:0060770); immunodeficiency 114 (Disease Ontology:DOID:0061080); malaria (Disease Ontology:DOID:12365); hematologic cancer (Disease Ontology:DOID:2531); abdominal aortic aneurysm (Disease Ontology:DOID:7693); chronic kidney disease (Disease Ontology:DOID:784); cleft lip (Disease Ontology:DOID:9296)", "pathway": " (mmu:20509); (R-MMU-196757)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10787414;12832086;15579899;19144319;20173027;21183079;21750661;25428506;30084848;30779550;31511694;36265513;37328777;7559435;8276792;8664315;9111015;9161403;9748272", "class_list": "", "function": "Antiporter that mediates the import of reduced folates, driven by the export of organic anions (PubMed:8276792, PubMed:8664315, PubMed:9111015, PubMed:9748272). Also acts as an importer of immunoreactive cyclic dinucleotides, but with a lower transporter activity (PubMed:31511694, PubMed:36265513). Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates (By similarity). Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (PubMed:8276792, PubMed:9111015). Also mediates the import of antifolate drug methotrexate (PubMed:8276792, PubMed:8664315, PubMed:9748272). 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Existence of four unique noncoding exons and promoters for mRFC and demonstrate a facile induction of mRNAs for mRFC and multidrug resistance-associated proteins 1 and 3 in intestine in response to changes in dietary folate intake, [RefSeq, PubMed]; Interaction between the E45 and K404 residues in the first and 11th transmembrane domains; the E45 residue appears to be the more dominant determinant of binding and anion sensitivity, [RefSeq, PubMed]; Reduced folate carrier 1 is present in retinal microvessels and crucial for the inner blood retinal barrier integrity. Publication Status: Online-Only, [RefSeq, PubMed]; Transporter that mediates the import of reduced folates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62450;Q62451", "ec_number_list": [], "go_molecular_function": "GO:0015350 methotrexate transmembrane transporter activity;GO:0042910 xenobiotic transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015297 antiporter activity;GO:0005542 folic acid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane;GO:0016020 membrane", "go_biological_process": "GO:0051958 methotrexate transport;GO:0007565 female pregnancy;GO:0009636 response to toxic substance;GO:0015711 organic anion transport;GO:0006855 xenobiotic transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P41438-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EBH1-1", "uniprot_id": [ { "id": "RASF5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5EBH1", "type": "external" } ], "mass": 46714.0, "length": 413, "protein_name": "Ras association domain-containing protein 5", "gene_name": "Rassf5", "organism": "Mouse", "refseq_name": "ras association domain-containing protein 5 isoform 2", "refseq_ac": [ { "id": "NP_001298023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298023", "type": "external" } ], "gene_names_uniprotkb": "Rassf5; Nore1; Rapl", "gene_names_refseq": "1300019G20Rik; Maxp1; Nore1A; Nore1B; Nore1; Rapl; Rassf5", "protein_names_uniprotkb": "Ras association domain-containing protein 5; New ras effector 1; RAPL; Regulator for cell adhesion and polarization enriched in lymphoid tissues", "protein_names_refseq": "Rap1-binding protein; new ras effector 1; novel ras effector 1; ras association domain-containing protein 5 isoform 2; ras association domain-containing protein 5; regulator for cell adhesion and polarization enriched in lymphoid tissues", "tax_id": 10090, "disease": "lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:54354)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11857081;11864565;11978988;12845325;16698549;18596699;21183079;21750661;25428506;31092054;33393458;34428180;37247756;9488663", "class_list": "", "function": "Histone demethylase Jmjd3 modulates osteoblast apoptosis induced by tumor necrosis factor-alpha through directly targeting RASSF5., [RefSeq, PubMed]; Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium. Publication Status: Online-Only, [RefSeq, PubMed]; Mapping to chromosome 1 and sequence variation of the murine Ras effector gene Nore1, [RefSeq, PubMed]; Nore1 inhibits age-associated myeloid lineage skewing and clonal hematopoiesis but facilitates termination of emergency (stress) granulopoiesis., [RefSeq, PubMed]; Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing (By similarity). May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O70407;Q6KAR0;Q8C2E8", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0007165 signal transduction;GO:0008285 negative regulation of cell population proliferation;GO:0006915 apoptotic process;GO:0031398 positive regulation of protein ubiquitination;GO:1900180 regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q5EBH1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AQ25-1", "uniprot_id": [ { "id": "SKT_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AQ25", "type": "external" } ], "mass": 213037.0, "length": 1946, "protein_name": "Sickle tail protein", "gene_name": "Etl4; Skt", "organism": "Mouse", "refseq_name": "sickle tail protein isoform c", "refseq_ac": [ { "id": "NP_001074475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074475", "type": "external" } ], "gene_names_uniprotkb": "Etl4; Skt; Etl4; Kiaa1217", "gene_names_refseq": "6620402G01Rik; 9430077C05Rik; E330027G05Rik; Etl-4; Etl4; Skt", "protein_names_uniprotkb": "Sickle tail protein; Enhancer trap locus 4", "protein_names_refseq": "sickle tail protein isoform c; sickle tail protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:208618)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;12522145;16204209;16452088;17114649;17242355;21183079;21750661;22517741;22645316;25428506;32848054;33440180;34428180;34678516;35822049;36852467;40021952;40885482", "class_list": "", "function": "A Genetic Screen Identifies Etl4-Deficiency Capable of Stabilizing the Haploidy in Embryonic Stem Cells., [RefSeq, PubMed]; Required for normal development of intervertebral disks., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 20, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 20, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 20, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 22, "binding_glycan_count": 0, "secondary_ac_list": "A2AUE9;A2AUF0;A2AUF1;Q75UV8;Q75UV9;Q80VK2;Q8BHX8;Q8BHY1;Q8CHA8;Q8R0K6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005856 cytoskeleton", "go_biological_process": "GO:0048706 embryonic skeletal system development", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "A2AQ25-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60854-1", "uniprot_id": [ { "id": "SPB6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60854", "type": "external" } ], "mass": 42599.0, "length": 378, "protein_name": "Serpin B6", "gene_name": "Serpinb6a; Serpinb6", "organism": "Mouse", "refseq_name": "serpin B6 isoform b", "refseq_ac": [ { "id": "NP_001157590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157590", "type": "external" } ], "gene_names_uniprotkb": "Serpinb6a; Serpinb6; Serpinb6a; Spi3", "gene_names_refseq": "4930482L21Rik; D330015H01Rik; PI-6; Serpinb6a; Serpinb6; Spi3; ovalbumin", "protein_names_uniprotkb": "Serpin B6; PI-6; Placental thrombin inhibitor; Proteinase inhibitor 6", "protein_names_refseq": "placental thrombin inhibitor; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6; serine (or cysteine) proteinase inhibitor, clade B, member 6a; serine protease inhibitor 3; serpin B6 isoform b; serpin B6", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 91 (Disease Ontology:DOID:0110536)", "pathway": " (mmu:20719); (R-MMU-6798695); (R-MMU-75205)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "17761692;20451170;21750661;22645316;23806337;24788674;25153642;28011936;28135057;28455723;28528544;31219806;32152506;33300544;34428180;34554936;36087923;37453647;37507081;37828378;7608171", "class_list": "", "function": "Absence of Serpinb6a causes progressive hair cell apoptosis and hearing loss in mice. Erratum:[J Genet Genomics. 2023 Jun;50(6):458. doi: 10.1016/j.jgg.2023.04.011. PMID: 37330250], [RefSeq, PubMed]; Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress. May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood., [UniProtKB, PubMed]; Mice heterozygous for the Serpinb6a null mutation show deficits in central auditory function after acoustic trauma., [RefSeq, PubMed]; Serpinb6a mRNA expression was more abundant in the male than in the female submandibular gland., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix", "go_biological_process": "GO:0008406 gonad development", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q60854-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q11011-1", "uniprot_id": [ { "id": "PSA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q11011", "type": "external" } ], "mass": 103325.0, "length": 920, "protein_name": "Puromycin-sensitive aminopeptidase", "gene_name": "Npepps", "organism": "Mouse", "refseq_name": "puromycin-sensitive aminopeptidase", "refseq_ac": [ { "id": "NP_032968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032968", "type": "external" } ], "gene_names_uniprotkb": "Npepps; Psa", "gene_names_refseq": "AAP-S; MP100; Npepps; Psa; goku", "protein_names_uniprotkb": "Puromycin-sensitive aminopeptidase; 3.4.11.14; AAP-S; Cytosol alanyl aminopeptidase; PSA", "protein_names_refseq": "cytosol alanyl aminopeptidase; puromycin-sensitive aminopeptidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:19155); (R-MMU-983168)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "10407043;11376108;11376114;16800626;18209067;20484733;20829225;21750661;21766205;21952136;25153642;25428506;26495903;30084848;30779550;31219806;31599954;33300544;34048566;34428180;37507081;37828378;39627609;39927985;7592939", "class_list": "", "function": "Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins., [UniProtKB, PubMed]; Findings show that by promoting autophagic protein clearance, PSA helps protect against accumulation of aggregation-prone proteins and proteotoxicity, [RefSeq, PubMed]; Nucleocytoplasmic transfer of cyclin dependent kinase 5 and its binding to puromycin-sensitive aminopeptidase in Dictyostelium discoideum, [RefSeq, PubMed]; PSA controls hepatic lipid metabolism by regulating the NRF2 signaling pathway., [RefSeq, PubMed]; These data indicate that PSA may play a role in limiting MHC class I Ag presentation in dendritic cells in vivo but that it is not essential for generating most MHC class I-presented peptides or for stimulating CTL responses to several Ags., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UZE0;Q5PR74;Q91VJ8", "ec_number_list": [ { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.4.11.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.14", "type": "external" }, { "id": "3.4.14.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.10", "type": "external" }, { "id": "3.4.11.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.3", "type": "external" }, { "id": "3.4.22.40", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.40", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0070006 metalloaminopeptidase activity;GO:0016285 alanyl aminopeptidase activity;GO:0008237 metallopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0043171 peptide catabolic process;GO:0071456 cellular response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q11011-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPQ2-1", "uniprot_id": [ { "id": "RPGR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EPQ2", "type": "external" } ], "mass": 151996.0, "length": 1331, "protein_name": "X-linked retinitis pigmentosa GTPase regulator-interacting protein 1", "gene_name": "Rpgrip1", "organism": "Mouse", "refseq_name": "X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001161987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161987", "type": "external" } ], "gene_names_uniprotkb": "Rpgrip1", "gene_names_refseq": "0610005A07Rik; 4930401L23Rik; 4930505G06Rik; A930002K18Rik; Rpgrip1; nmf247", "protein_names_uniprotkb": "X-linked retinitis pigmentosa GTPase regulator-interacting protein 1; RPGR-interacting protein 1", "protein_names_refseq": "RPGR-interacting protein 1; X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 isoform 2; X-linked retinitis pigmentosa GTPase regulator-interacting protein 1", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340); Leber congenital amaurosis 6 (Disease Ontology:DOID:0110329); cone-rod dystrophy 13 (Disease Ontology:DOID:0111016); retinitis pigmentosa (Disease Ontology:DOID:10584); Leber hereditary optic neuropathy (Disease Ontology:DOID:705)", "pathway": " (mmu:77945)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11104772;12140192;12651948;21750661;25398945;29100828;29650680;29899041;30084848;34428180", "class_list": "", "function": "Loss of Rpgrip1 expression is associated with Ciliopathy., [RefSeq, PubMed]; May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CAC2;Q8CDJ9;Q91WE0;Q9CUK6;Q9D5Q1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005929 cilium;GO:0035253 ciliary rootlet;GO:0015630 microtubule cytoskeleton;GO:0045171 intercellular bridge", "go_biological_process": "GO:0007601 visual perception;GO:0060041 retina development in camera-type eye;GO:0046548 retinal rod cell development;GO:1905515 non-motile cilium assembly;GO:0042462 eye photoreceptor cell development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9EPQ2-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59158-1", "uniprot_id": [ { "id": "S12A3_MOUSE", "url": "https://www.uniprot.org/uniprot/P59158", "type": "external" } ], "mass": 110694.0, "length": 1002, "protein_name": "Solute carrier family 12 member 3", "gene_name": "Slc12a3", "organism": "Mouse", "refseq_name": "solute carrier family 12 member 3 isoform 1", "refseq_ac": [ { "id": "NP_001192240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192240", "type": "external" } ], "gene_names_uniprotkb": "Slc12a3; Ncc; Tsc", "gene_names_refseq": "NCCT; NCC; Slc12a3; TSC", "protein_names_uniprotkb": "Solute carrier family 12 member 3; Na-Cl symporter; Thiazide-sensitive sodium-chloride cotransporter", "protein_names_refseq": "Na-Cl symporter; solute carrier family 12 member 3 isoform 1; thiazide-sensitive sodium-chloride cotransporter", "tax_id": 10090, "disease": "Gitelman syndrome (Disease Ontology:DOID:0050450); essential hypertension (Disease Ontology:DOID:10825); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:20497); (R-MMU-426117)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "15068971;16263722;17488636;19633012;20091762;20392800;21183079;21750661;24761002;26099046;28940314;29483225;29993276;30084848;35557966;36370249", "class_list": "", "function": "Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules (PubMed:15068971, PubMed:17488636, PubMed:19633012, PubMed:36370249). Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2 (PubMed:26099046). May act either independently of IL18R1, or in a complex with IL18R1 (PubMed:26099046)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 18, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0015081 sodium ion transmembrane transporter activity;GO:0015378 sodium:chloride symporter activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0016324 apical plasma membrane;GO:0031982 vesicle", "go_biological_process": "GO:0006884 cell volume homeostasis;GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport;GO:0035725 sodium ion transmembrane transport;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P59158-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61290-1", "uniprot_id": [ { "id": "PSME3_MOUSE", "url": "https://www.uniprot.org/uniprot/P61290", "type": "external" } ], "mass": 29506.0, "length": 254, "protein_name": "Proteasome activator complex subunit 3", "gene_name": "Psme3", "organism": "Mouse", "refseq_name": "proteasome activator complex subunit 3", "refseq_ac": [ { "id": "NP_035322", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035322", "type": "external" } ], "gene_names_uniprotkb": "Psme3", "gene_names_refseq": "Ki; PA28gamma; Psme3; REGgamma; pa28g", "protein_names_uniprotkb": "Proteasome activator complex subunit 3; 11S regulator complex subunit gamma; Activator of multicatalytic protease subunit 3; Ki nuclear autoantigen; PA28gamma; PA28g; Proteasome activator 28 subunit gamma; REG-gamma", "protein_names_refseq": "11S regulator complex subunit gamma; REG-gamma; activator of multicatalytic protease subunit 3; ki nuclear autoantigen; proteaseome (prosome, macropain) 28 subunit, 3; proteasome activator 28 subunit gamma; proteasome activator complex subunit 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:19192); (R-MMU-9907900)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10608895;12650640;21750661;25153642;31219806;34260942;34428180;36330811;38423356;38477820;9162094;9218537;9590240", "class_list": "", "function": "11S Proteasome Activator REGgamma Promotes Aortic Dissection by Inhibiting RBM3 (RNA Binding Motif Protein 3) Pathway., [RefSeq, PubMed]; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome., [UniProtKB, UniProtKB]; Loss of PA28gamma exacerbates imbalanced differentiation of bone marrow stromal cells during bone formation and bone healing in mice., [RefSeq, PubMed]; REGgamma Mitigates Radiation-Induced Enteritis by Preserving Mucin Secretion and Sustaining Microbiome Homeostasis., [RefSeq, PubMed]; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35563;P97373;Q12920;Q13172;Q9BQD9", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0061133 endopeptidase activator activity;GO:0002039 p53 binding;GO:0097371 MDM2/MDM4 family protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0036064 ciliary basal body", "go_biological_process": "GO:0006915 apoptotic process;GO:2001237 negative regulation of extrinsic apoptotic signaling pathway;GO:2000045 regulation of G1/S transition of mitotic cell cycle;GO:0061136 regulation of proteasomal protein catabolic process;GO:0019884 antigen processing and presentation of exogenous antigen", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P61290-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100010001001.011.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59281-1", "uniprot_id": [ { "id": "RHG39_MOUSE", "url": "https://www.uniprot.org/uniprot/P59281", "type": "external" } ], "mass": 125206.0, "length": 1107, "protein_name": "Rho GTPase-activating protein 39", "gene_name": "Arhgap39", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 39 isoform 1", "refseq_ac": [ { "id": "NP_001161760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161760", "type": "external" } ], "gene_names_uniprotkb": "Arhgap39; D15Wsu169e; Kiaa1688", "gene_names_refseq": "9530053N22; Arhgap39; D15Wsu169e; Kiaa1688; Porf-2", "protein_names_uniprotkb": "Rho GTPase-activating protein 39", "protein_names_refseq": "preoptic regulatory factor-2; rho GTPase-activating protein 39 isoform 1; rho GTPase-activating protein 39", "tax_id": 10090, "disease": "", "pathway": " (mmu:223666); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013408); (R-MMU-9013423); (R-MMU-9035034)", "pathway_count": 10, "publication_count": 10, "publication_id_list": "15345747;17114649;19144319;21183079;21750661;22645316;25428506;28368047;29938386;40885482", "class_list": "", "function": "Dendritic structures of CA1 pyramidal neurons were altered in Rho GTPase activating protein 39/Vilse homozygous knockout (Vilse(Delta/Delta) mice. Publication Status: Online-Only, [RefSeq, PubMed]; Porf-2 is capable of binding to the EphB1 receptor, causing the outgrowth of axons to stop and retract upon EphB forward signal transduction within the axon growth cone., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZD4;Q6P9R6", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0098794 postsynapse", "go_biological_process": "GO:0007165 signal transduction;GO:0099173 postsynapse organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P59281-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZX8-1", "uniprot_id": [ { "id": "SPAG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80ZX8", "type": "external" } ], "mass": 100670.0, "length": 901, "protein_name": "Sperm-associated antigen 1", "gene_name": "Spag1", "organism": "Mouse", "refseq_name": "sperm-associated antigen 1 isoform 3", "refseq_ac": [ { "id": "NP_036161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036161", "type": "external" } ], "gene_names_uniprotkb": "Spag1; Tpis", "gene_names_refseq": "Spag1; tpis", "protein_names_uniprotkb": "Sperm-associated antigen 1; Infertility-related sperm protein Spag-1; TPIS; TPR-containing protein involved in spermatogenesis", "protein_names_refseq": "TPR-containing protein involved in spermatogenesis; infertility-related sperm protein Spag-1; sperm-associated antigen 1 isoform 3", "tax_id": 10090, "disease": "primary ciliary dyskinesia 28 (Disease Ontology:DOID:0110607)", "pathway": " (mmu:26942)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10527845;15979907;21183079;21750661;27053660;34428180", "class_list": "", "function": "Findings broaden our knowledge of SPAG-1, showing that it exerts a role in oocyte meiotic execution via its involvement in AMPK and MAPK signaling pathways., [RefSeq, PubMed]; May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity (By similarity)., [UniProtKB, UniProtKB]; The number of PCR positives of sperm mtDNA in two-cell embryos was significantly increased following sperm incubation with anti-tetratricopeptide repeat-containing protein involved in spermatogenesis (tpis)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CCK7;Q9QZJ3;Q9QZJ4", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0097228 sperm principal piece", "go_biological_process": "GO:0007338 single fertilization;GO:0070286 axonemal dynein complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80ZX8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2Y0-1", "uniprot_id": [ { "id": "OBI1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2Y0", "type": "external" } ], "mass": 79958.0, "length": 722, "protein_name": "ORC ubiquitin ligase 1", "gene_name": "Obi1", "organism": "Mouse", "refseq_name": "ORC ubiquitin ligase 1 isoform X2", "refseq_ac": [ { "id": "XP_011243508", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011243508", "type": "external" } ], "gene_names_uniprotkb": "Obi1; Rnf219", "gene_names_refseq": "2610206B13Rik; 2810449K13Rik; Obi1; Obl1; Rnf219", "protein_names_uniprotkb": "ORC ubiquitin ligase 1; 2.3.2.27; OBI1; RING finger protein 219", "protein_names_refseq": "ORC ubiquitin ligase 1 isoform X2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72486); (R-MMU-69273)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;31219806", "class_list": "", "function": "E3 ubiquitin ligase essential for DNA replication origin activation during S phase. Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9CYU1;Q9D1Y0", "ec_number_list": [ { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0000785 chromatin", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0006275 regulation of DNA replication;GO:0051865 protein autoubiquitination;GO:0006513 protein monoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8K2Y0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R3Q2-1", "uniprot_id": [ { "id": "PP6R2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R3Q2", "type": "external" } ], "mass": 100460.0, "length": 923, "protein_name": "Serine/threonine-protein phosphatase 6 regulatory subunit 2", "gene_name": "Ppp6r2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ppp6r2; Kiaa0685; Pp6r2; Saps2", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 6 regulatory subunit 2; SAPS domain family member 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:71474)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15345747;16769727;21183079;21750661;31219806;32848054;40021952;40885482", "class_list": "", "function": "Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9CXB7", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0005737 cytoplasm", "go_biological_process": "GO:0009966 regulation of signal transduction;GO:0006516 glycoprotein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8R3Q2-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61550-1", "uniprot_id": [ { "id": "RAD21_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61550", "type": "external" } ], "mass": 72083.0, "length": 635, "protein_name": "Double-strand-break repair protein rad21 homolog", "gene_name": "Rad21", "organism": "Mouse", "refseq_name": "double-strand-break repair protein rad21 homolog", "refseq_ac": [ { "id": "NP_033035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033035", "type": "external" } ], "gene_names_uniprotkb": "Rad21; Hr21; Scc1", "gene_names_refseq": "Rad21; SCC1; mHR21; mKIAA0078", "protein_names_uniprotkb": "Double-strand-break repair protein rad21 homolog; 64-kDa carboxy-terminal product; PW29; Pokeweed agglutinin-binding protein 29; SCC1 homolog; mHR21", "protein_names_refseq": "PW29; RAD21 homolog; SCC1 homolog; double-strand-break repair protein rad21 homolog; pokeweed agglutinin-binding protein 29", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); colorectal carcinoma (Disease Ontology:DOID:0080199); Cornelia de Lange syndrome 4 (Disease Ontology:DOID:0080508); Cornelia de Lange syndrome (Disease Ontology:DOID:11725); brain cancer (Disease Ontology:DOID:1319); endometrial cancer (Disease Ontology:DOID:1380); congenital heart disease (Disease Ontology:DOID:1682); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:19357); (R-MMU-2467813); (R-MMU-2468052); (R-MMU-2470946); (R-MMU-2500257); (R-MMU-3108214)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "10375619;11471062;16452087;18237772;21183079;21750661;25428506;31219806;34428180;39627609;8521526;8812457", "class_list": "", "function": "As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (PubMed:18237772). May control RUNX1 gene expression. Binds to and represses APOB gene promoter (By similarity). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; May promote apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70219;Q3TQ09;Q810A8;Q91VB9;Q9DBU4", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0140297 DNA-binding transcription factor binding;GO:0106222 lncRNA binding", "go_cellular_component": "GO:0030892 mitotic cohesin complex;GO:0030893 meiotic cohesin complex;GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007059 chromosome segregation;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q61550-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04888-1", "uniprot_id": [ { "id": "SOX10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q04888", "type": "external" } ], "mass": 49949.0, "length": 466, "protein_name": "Transcription factor SOX-10", "gene_name": "Sox10", "organism": "Mouse", "refseq_name": "transcription factor SOX-10", "refseq_ac": [ { "id": "NP_035567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035567", "type": "external" } ], "gene_names_uniprotkb": "Sox10; Sox-10; Sox21", "gene_names_refseq": "Dom; Sox10; Sox21; gt", "protein_names_uniprotkb": "Transcription factor SOX-10; Protein SOX-21; Transcription factor SOX-M", "protein_names_refseq": "SRY-box containing gene 10; dominant megacolon; transcription factor SOX-10; transcription factor SOX-M", "tax_id": 10090, "disease": "PCWH syndrome (Disease Ontology:DOID:0090111); Waardenburg syndrome type 4C (Disease Ontology:DOID:0110955); Waardenburg syndrome type 2E (Disease Ontology:DOID:0110956); Hirschsprung's disease (Disease Ontology:DOID:10487); Kallmann syndrome (Disease Ontology:DOID:3614); Waardenburg syndrome (Disease Ontology:DOID:9258)", "pathway": " (mmu:20665); (R-MMU-9856649)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "19304657;21750661;24204311;26525805;27532821;35820727;8441686;8921394;9027483;9425902;9560246;9760192", "class_list": "", "function": "Transcription factor that plays a central role in developing and mature glia (PubMed:24204311, PubMed:27532821). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (PubMed:24204311, PubMed:27532821). Once induced, MYRF cooperates with SOX10 to implement the myelination program (PubMed:24204311). Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). Transcriptional activator of MBP, via binding to the gene promoter (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08518;O09141;O54856;P70416", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0000785 chromatin", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0071393 cellular response to progesterone stimulus;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q04888-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHG6-1", "uniprot_id": [ { "id": "RCAN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHG6", "type": "external" } ], "mass": 28137.0, "length": 251, "protein_name": "Calcipressin-1", "gene_name": "Rcan1", "organism": "Mouse", "refseq_name": "calcipressin-1 isoform 1", "refseq_ac": [ { "id": "NP_001075018", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075018", "type": "external" } ], "gene_names_uniprotkb": "Rcan1; Dscr1", "gene_names_refseq": "Adapt78; CALP1L; CSP1; DSC1; Dscr1; MCIP1; RCN1; Rcan1", "protein_names_uniprotkb": "Calcipressin-1; Down syndrome critical region protein 1 homolog; MCIP1; Myocyte-enriched calcineurin-interacting protein 1; Regulator of calcineurin 1", "protein_names_refseq": "calcineurin inhibitor; calcipressin-1 isoform 1; calcipressin-1; down syndrome critical region protein 1 homolog; myocyte-enriched calcineurin-interacting protein 1", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (mmu:54720)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10722714;11080588;11231093;12063245;12809556;21183079;21750661;25428506;31219806;34428180;36450444;36933529;39053690", "class_list": "", "function": "DSCR1 deficiency ameliorates the Abeta pathology of Alzheimer's disease by enhancing microglial activity. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (PubMed:11231093)., [UniProtKB, PubMed]; Mice with double knockout of Egr-1 and RCAN1 exhibit reduced inflammation during Pseudomonas aeruginosa lung infection., [RefSeq, PubMed]; Suppression of RCAN1 alleviated lipid accumulation and mitochondrial fission in diabetic cardiomyopathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNY3;Q91WQ4;Q9JK50;Q9JK51;Q9JKK2;Q9JKK3", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0003676 nucleic acid binding;GO:0004864 protein phosphatase inhibitor activity;GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0002931 response to ischemia;GO:0006979 response to oxidative stress;GO:0019722 calcium-mediated signaling;GO:0007614 short-term memory;GO:0009612 response to mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9JHG6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61412-1", "uniprot_id": [ { "id": "VSX2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61412", "type": "external" } ], "mass": 39436.0, "length": 361, "protein_name": "Visual system homeobox 2", "gene_name": "Vsx2", "organism": "Mouse", "refseq_name": "visual system homeobox 2 isoform 2", "refseq_ac": [ { "id": "NP_031727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031727", "type": "external" } ], "gene_names_uniprotkb": "Vsx2; Chx10", "gene_names_refseq": "Chx10; Hox-10; Hox10; Vsx2; or", "protein_names_uniprotkb": "Visual system homeobox 2; Ceh-10 homeodomain-containing homolog; Homeobox protein CHX10", "protein_names_refseq": "C. elegans ceh-10 homeo domain containing homolog; ceh-10 homeodomain-containing homolog; homeobox protein CHX10; ocular retardation; visual system homeobox 2 isoform 2", "tax_id": 10090, "disease": "isolated microphthalmia 2 (Disease Ontology:DOID:0060839); blindness (Disease Ontology:DOID:1432)", "pathway": " (mmu:12677)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "16236706;16547132;17919464;18417110;18539116;19843539;23028343;27477290;29187734;7914735;8630490", "class_list": "", "function": "Acts as a transcriptional regulator through binding to DNA at the consensus sequence 5'-[TC]TAATT[AG][AG]-3' upstream of gene promoters (PubMed:17919464, PubMed:18539116). Plays a significant role in the specification and morphogenesis of the sensory retina (PubMed:8630490). May play a role in specification of V2a interneurons during spinal cord development (PubMed:18539116). Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex, such as VSX1 and MNX1 (PubMed:17919464, PubMed:18539116, PubMed:27477290). Acts as a positive transcriptional regulator of NXNL1; regulation is significantly increased in synergy with VSX1 (PubMed:19843539). Acts as a negative transcriptional regulator of MITF (PubMed:23028343). Represses SAG transcription by competitive inhibition of ISL1-LHX3 response elements (By similarity). Binds to the photoreceptor conserved element-1 (PCE-1) in the promoter of rod photoreceptor arrestin SAG and acts as a transcriptional repressor (PubMed:16236706). Involved in the development of retinal ganglion cells (RGCs) which leads to release of SHH by RGCs, promoting Hedgehog signaling and subsequent proliferation of retinal progenitor cells (PubMed:18417110). Participates in the development of the cells of the inner nuclear layer, by promoting postnatal differentiation of bipolar cells with a comparable inhibition of rod cell differentiation (PubMed:16547132, PubMed:8630490). May play a role in the maintenance of neural retina identity during development by regulation of canonical Wnt genes and CTNNB1 localization, suggesting a role in the regulation of canonical Wnt signaling (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a member of the Vsx (visual system homeobox) family which belongs to the larger PRD homeobox class. The encoded protein is required for eye organogenesis and controls retinal development. Disruption of this gene is associated with ocular retardation J (orJ), a mouse disease which causes microphthalmia, retinal degeneration and optic nerve aplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q61412-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49443-1", "uniprot_id": [ { "id": "PPM1A_MOUSE", "url": "https://www.uniprot.org/uniprot/P49443", "type": "external" } ], "mass": 42433.0, "length": 382, "protein_name": "Protein phosphatase 1A", "gene_name": "Ppm1a", "organism": "Mouse", "refseq_name": "protein phosphatase 1A", "refseq_ac": [ { "id": "NP_032936", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032936", "type": "external" } ], "gene_names_uniprotkb": "Ppm1a; Pppm1a", "gene_names_refseq": "2310003C21Rik; 2900017D14Rik; MMPa-2; MPPa-1; Ppm1a", "protein_names_uniprotkb": "Protein phosphatase 1A; 3.1.3.16; PP2C-alpha; Protein phosphatase 2C isoform alpha; Protein phosphatase IA", "protein_names_refseq": "Mpp alpha; PP2C-alpha; protein phosphatase 1A; protein phosphatase IA", "tax_id": 10090, "disease": "", "pathway": " (mmu:19042); (R-MMU-2173795); (R-MMU-380972)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "17242355;21183079;21750661;22781750;23088624;25428506;28011936;31791585;32024237;33725478;35820727;36752205;8056349", "class_list": "", "function": "Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling (By similarity). Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB., [UniProtKB, PubMed]; PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPARgamma at Ser273. Publication Status: Online-Only, [RefSeq, PubMed]; Protein phosphatase PPM1A inhibition attenuates osteoarthritis via regulating TGF-beta/Smad2 signaling in chondrocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Protein phosphatase magnesium-dependent 1A induces inflammation in rheumatoid arthritis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0033192 calmodulin-dependent protein phosphatase activity;GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0044325 transmembrane transporter binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0046827 positive regulation of protein export from nucleus;GO:0045893 positive regulation of DNA-templated transcription;GO:0030514 negative regulation of BMP signaling pathway;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P49443-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MV7-1", "uniprot_id": [ { "id": "RNF17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MV7", "type": "external" } ], "mass": 185600.0, "length": 1640, "protein_name": "RING finger protein 17", "gene_name": "Rnf17", "organism": "Mouse", "refseq_name": "RING finger protein 17", "refseq_ac": [ { "id": "NP_001028215", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028215", "type": "external" } ], "gene_names_uniprotkb": "Rnf17", "gene_names_refseq": "MMIP-2; Mmip2; Rnf17; TDRD4", "protein_names_uniprotkb": "RING finger protein 17; Mad member-interacting protein 2; Mmip-2", "protein_names_refseq": "Max dimerization protein member-interacting protein 2; RING finger protein 17; mad member-interacting protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:30054)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10597267;11279525;11420703;16093322;19584108;21183079;21750661;23576753;26115953;31599954;37428816", "class_list": "", "function": "RNF17 is a component of a novel germ cell nuage and is required for differentiation of male germ cells. GeneRIF: RNF17 is required for spermiogenesis in mouse. There are two RNF17 protein isoforms: RNF17L and RNF17S. RNF17 localizes to a novel nuage in germ cells., [RefSeq, PubMed]; RNF17 shapes adult meiotic piRNA content by suppressing the production of secondary piRNAs, [RefSeq, PubMed]; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis., [UniProtKB, PubMed, PubMed]; Two RNA binding proteins, ADAD2 and RNF17, interact to form a heterogeneous population of novel meiotic germ cell granules with developmentally dependent organelle association. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T4H2;Q3T4H3;Q4FZG6;Q8CDR4;Q9QXQ2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q99MV7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GQT6-1", "uniprot_id": [ { "id": "SCAP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6GQT6", "type": "external" } ], "mass": 139611.0, "length": 1276, "protein_name": "Sterol regulatory element-binding protein cleavage-activating protein", "gene_name": "Scap", "organism": "Mouse", "refseq_name": "sterol regulatory element-binding protein cleavage-activating protein", "refseq_ac": [ { "id": "NP_001001144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001144", "type": "external" } ], "gene_names_uniprotkb": "Scap; Kiaa0199", "gene_names_refseq": "9530044G19; Scap; mKIAA0199", "protein_names_uniprotkb": "Sterol regulatory element-binding protein cleavage-activating protein; SCAP; SREBP cleavage-activating protein", "protein_names_refseq": "SREBP cleavage activating protein; Sreb cleavage-activating protein; sterol regulatory element-binding protein cleavage-activating protein", "tax_id": 10090, "disease": "end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:235623); (R-MMU-1655829)", "pathway_count": 2, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;11358865;14512514;17242355;18250455;18299400;19224205;20173027;21183079;21750661;21952136;24129315;25428506;25428507;25605945;26311497;28849786;29068315;30084848;30779550;30899004;31219806;34428180;35820727;38591127;9854040", "class_list": "", "function": "1,003 genes showed statistically significant increased expression in livers of transgenic SREBP-1a mice, 505 increased in livers of transgenic SREBP-2 mice, and 343 showed decreased expression in Scap-/- livers., [RefSeq, PubMed]; Escort protein required for cholesterol as well as lipid homeostasis (PubMed:11358865, PubMed:9854040). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:11358865, PubMed:29068315, PubMed:9854040). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity). Binds cholesterol via its SSD domain (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; N-glycosylation of SCAP exacerbates hepatocellular inflammation and lipid accumulation via ACSS2-mediated histone H3K27 acetylation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6A0A6;Q6NS67;Q7TNG7;Q80UI6", "ec_number_list": [], "go_molecular_function": "GO:0015485 cholesterol binding;GO:0044877 protein-containing complex binding;GO:0032934 sterol binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012507 ER to Golgi transport vesicle membrane;GO:0032991 protein-containing complex;GO:0032936 SREBP-SCAP complex", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006629 lipid metabolic process;GO:0006955 immune response;GO:0008203 cholesterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q6GQT6-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98084-1", "uniprot_id": [ { "id": "APBA2_MOUSE", "url": "https://www.uniprot.org/uniprot/P98084", "type": "external" } ], "mass": 82758.0, "length": 750, "protein_name": "Amyloid-beta A4 precursor protein-binding family A member 2", "gene_name": "Apba2", "organism": "Mouse", "refseq_name": "amyloid-beta A4 precursor protein-binding family A member 2 isoform a", "refseq_ac": [ { "id": "NP_001278095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278095", "type": "external" } ], "gene_names_uniprotkb": "Apba2; X11l", "gene_names_refseq": "Apba2; X11-like; X11L; XllL; mXllL", "protein_names_uniprotkb": "Amyloid-beta A4 precursor protein-binding family A member 2; Adapter protein X11beta; Mint-2; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2", "protein_names_refseq": "Mint 2; adapter protein X11beta; amyloid beta (A4) precursor protein-binding, family A, member 2; amyloid-beta A4 precursor protein-binding family A member 2 isoform a; mint-2; neuron-specific X11L protein; neuronal Munc18-1-interacting protein 2", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:11784)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;15345747;21750661;27268412;30411795;30988517;7719031", "class_list": "", "function": "A rare autism-associated MINT2/APBA2 mutation disrupts neurexin trafficking and synaptic function. Publication Status: Online-Only, [RefSeq, PubMed]; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta., [UniProtKB]; Results indicate that both X11 and X11L exert largely in brain neurons, but X11 may also function in peripheral tissues., [RefSeq, PubMed]; X11 and X11L regulate the glutamate receptor micro-localization to the extrasynaptic region, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9652, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6PAJ2", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0098793 presynapse", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007626 locomotory behavior;GO:0015031 protein transport;GO:0007268 chemical synaptic transmission;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P98084-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91Y74-1", "uniprot_id": [ { "id": "SIA4C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91Y74", "type": "external" } ], "mass": 38058.0, "length": 333, "protein_name": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4", "gene_name": "St3gal4", "organism": "Mouse", "refseq_name": "CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 4", "refseq_ac": [ { "id": "NP_033204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033204", "type": "external" } ], "gene_names_uniprotkb": "St3gal4; Siat4c", "gene_names_refseq": "SIAT4-C; ST3Gal IV; ST3GalIV; Siat4c; St3gal4", "protein_names_uniprotkb": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4; 2.4.3.2; 2.4.3.4; 2.4.3.6; Alpha 2,3-ST 4; Alpha 2,3-sialyltransferase IV; Beta-galactoside alpha-2,3-sialyltransferase 4; Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; Gal-beta-1,4-GlcNAc-alpha-2,3-sialyltransferase; N-acetyllactosaminide alpha-2,3-sialyltransferase; SIAT4-C; ST3Gal IV; ST3GalIV; Sialyltransferase 4C", "protein_names_refseq": "CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 4; N-acetyllactosaminide alpha-2,3-sialyltransferase; alpha 2,3-ST 4; alpha 2,3-sialyltransferase IV; beta-galactoside alpha-2,3-sialyltransferase 4; gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase; gal-beta-1,4-GlcNAc-alpha-2,3-sialyltransferase; sialyltransferase 4C (beta-galactosidase alpha-2,3-sialytransferase); sialyltransferase 4C (beta-galactoside alpha-2,3-sialytransferase)", "tax_id": 10090, "disease": "", "pathway": " (mmu:20443); (R-MMU-2022854); (R-MMU-4085001); (R-MMU-9037629); (R-MMU-975577); (R-MMU-977068)", "pathway_count": 6, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11389169;12097641;18299400;18519646;20173027;21750661;21952136;25428506;25498912;30084848;34428180;34462883;35820727;38687790;9184827", "class_list": "glycogene;glycosyltransferase", "function": "A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (By similarity) (PubMed:12097641). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc- and Galbeta-(1->4)-GlcNAc-terminated glycoconjugates through an alpha2-3 linkage (By similarity) (PubMed:9184827). Plays a major role in hemostasis. Responsible for sialylation of plasma VWF/von Willebrand factor, preventing its recognition by asialoglycoprotein receptors (ASGPR) and subsequent clearance. Regulates ASGPR-mediated clearance of platelets (PubMed:12097641). Participates in the biosynthesis of the sialyl Lewis X epitopes, both on O- and N-glycans, which are recognized by SELE/E-selectin, SELP/P-selectin and SELL/L-selectin. Essential for selectin-mediated rolling and adhesion of leukocytes during extravasation (PubMed:25498912). Contributes to adhesion and transendothelial migration of neutrophils likely through terminal sialylation of CXCR2 (PubMed:18519646). In glycosphingolipid biosynthesis, sialylates GM1 and GA1 gangliosides to form GD1a and GM1b, respectively (By similarity). Metabolizes brain c-series ganglioside GT1c forming GQ1c (By similarity). Synthesizes ganglioside LM1 (IV3Neu5Ac-nLc4Cer), a major structural component of peripheral nerve myelin (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IV., [RefSeq, PubMed]; Caveolin-1 knockout mice have altered serum N-glycan profile and sialyltransferase tissue expression., [RefSeq, PubMed]; Operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 9577, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "P97354;Q61325", "ec_number_list": [ { "id": "2.4.3.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.9", "type": "external" }, { "id": "2.4.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.2", "type": "external" }, { "id": "2.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.4", "type": "external" }, { "id": "2.4.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.6", "type": "external" } ], "go_molecular_function": "GO:0047288 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase;GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity;GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity;GO:0008373 sialyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane;GO:0000139 Golgi membrane", "go_biological_process": "GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0050890 cognition;GO:0009101 glycoprotein biosynthetic process;GO:0009247 glycolipid biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 2417, "hit_score": 2.1, "record_id": "Q91Y74-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q18PI6-1", "uniprot_id": [ { "id": "SLAF5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q18PI6", "type": "external" } ], "mass": 37378.0, "length": 329, "protein_name": "SLAM family member 5", "gene_name": "Cd84", "organism": "Mouse", "refseq_name": "SLAM family member 5 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001239401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239401", "type": "external" } ], "gene_names_uniprotkb": "Cd84; Slamf5", "gene_names_refseq": "A130013D22Rik; CDw84; Cd84; SLAMF5", "protein_names_uniprotkb": "SLAM family member 5; Leukocyte differentiation antigen CD84; Signaling lymphocytic activation molecule 5", "protein_names_refseq": "SLAM family member 5 isoform 2 precursor; SLAM family member 5; leukocyte differentiation antigen CD84; signaling lymphocytic activation molecule 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:12523); (R-MMU-202733)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10079287;11689425;16037392;17322886;18250455;20153220;20628063;20962259;21750661;25801429;28935714;31219806;34428180;36210013", "class_list": "", "function": "Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (PubMed:20962259). Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (PubMed:20962259). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells (By similarity). Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation (PubMed:20153220). In germinal centers involved in maintaining B cell tolerance and in preventing autoimmunity (PubMed:25801429). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (By similarity). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (PubMed:20628063). Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q18PI7;Q3TBT1;Q3U0A2;Q8BFV0;Q9Z178", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0032701 negative regulation of interleukin-18 production;GO:0032693 negative regulation of interleukin-10 production;GO:0006955 immune response;GO:0007155 cell adhesion;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q18PI6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55100-1", "uniprot_id": [ { "id": "SNG1_MOUSE", "url": "https://www.uniprot.org/uniprot/O55100", "type": "external" } ], "mass": 25653.0, "length": 234, "protein_name": "Synaptogyrin-1", "gene_name": "Syngr1", "organism": "Mouse", "refseq_name": "synaptogyrin-1 isoform 1b", "refseq_ac": [ { "id": "NP_033329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033329", "type": "external" } ], "gene_names_uniprotkb": "Syngr1", "gene_names_refseq": "Syngr1b; Syngr1; p29", "protein_names_uniprotkb": "Synaptogyrin-1", "protein_names_refseq": "synaptogyrin-1 isoform 1b", "tax_id": 10090, "disease": "", "pathway": " (mmu:20972); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10595519;12928441;21750661;25428506;30084848;31219806;31805305;33300544;9760194", "class_list": "", "function": "Cellugyrin and synaptogyrin have roles in facilitating targeting of synaptophysin to a ubiquitous synaptic vesicle-sized compartment, [RefSeq, PubMed]; Enhanced functional recovery by levodopa is associated with decreased levels of synaptogyrin following stroke in aged mice., [RefSeq, PubMed]; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short-term and long-term synaptic plasticity (PubMed:10595519)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EI16;Q543Y5;Q9DCB0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0031594 neuromuscular junction;GO:0042470 melanosome;GO:0030672 synaptic vesicle membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0045055 regulated exocytosis;GO:0048169 regulation of long-term neuronal synaptic plasticity;GO:0006605 protein targeting;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O55100-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5V9-1", "uniprot_id": [ { "id": "S45A4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0P5V9", "type": "external" } ], "mass": 85765.0, "length": 785, "protein_name": "Polyamine-transporter SLC45A4", "gene_name": "Slc45a4", "organism": "Mouse", "refseq_name": "polyamine-transporter SLC45A4 isoform 1", "refseq_ac": [ { "id": "NP_001028391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028391", "type": "external" } ], "gene_names_uniprotkb": "Slc45a4; Kiaa1126", "gene_names_refseq": "9330175B01Rik; Slc45a4", "protein_names_uniprotkb": "Polyamine-transporter SLC45A4; Solute carrier family 45 member 4", "protein_names_refseq": "polyamine-transporter SLC45A4 isoform 1; polyamine-transporter SLC45A4", "tax_id": 10090, "disease": "", "pathway": " (mmu:106068)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;25164149;31219806;37828378;40836097", "class_list": "", "function": "MRNA expression of SLC45A2 in eyes and skin and of SLC45A3 primarily in the prostate, but also in other tissues, whereas SLC45A4 showed a predominantly ubiquitous expression, [RefSeq, PubMed]; Neuronal polyamine-transporter involved in pain perception (PubMed:40836097). Transports polyamines such as putrescine, cadaverine, spermine and spermidine (By similarity). Expressed in sensory neuron subtypes within the dorsal root ganglion, where it regulates the excitability of C-polymodal nociceptors by mediating polyamine transport (PubMed:40836097)., [UniProtKB, UniProtKB, PubMed]; Neuronal polyamine-transporter involved in pain perception. Transports polyamines such as putrescine, cadaverine, spermine and spermidine. Expressed in sensory neuron subtypes within the dorsal root ganglion, where it regulates the excitability of C-polymodal nociceptors by mediating polyamine transport., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCG5;Q3V0B8;Q69ZR4;Q6PDG3", "ec_number_list": [], "go_molecular_function": "GO:0008506 sucrose:proton symporter activity;GO:0015489 putrescine transmembrane transporter activity;GO:0015203 polyamine transmembrane transporter activity;GO:0015606 spermidine transmembrane transporter activity;GO:0000297 spermine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0019233 sensory perception of pain;GO:0048266 behavioral response to pain;GO:0015770 sucrose transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q0P5V9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60960-1", "uniprot_id": [ { "id": "IMA5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60960", "type": "external" } ], "mass": 60183.0, "length": 538, "protein_name": "Importin subunit alpha-5", "gene_name": "Kpna1", "organism": "Mouse", "refseq_name": "importin subunit alpha-5 isoform 1", "refseq_ac": [ { "id": "NP_032491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032491", "type": "external" } ], "gene_names_uniprotkb": "Kpna1; Rch2", "gene_names_refseq": "IPOA5; Kpna1; NPI1; Rch2; mSRP1", "protein_names_uniprotkb": "Importin subunit alpha-5; Importin alpha-S1; Karyopherin subunit alpha-1; NPI-1; Nucleoprotein interactor 1; RAG cohort protein 2; SRP1-beta", "protein_names_refseq": "NPI-1; RAG cohort protein 2; SRP1-beta; importin alpha 5; importin alpha-S1; importin subunit alpha-1; importin subunit alpha-5 isoform 1; importin subunit alpha-5; karyopherin (importin) alpha 1; m-importin-alpha-S1; nucleoprotein interactor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:16646); (R-MMU-140342); (R-MMU-68616); (R-MMU-909733)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;10692581;18716025;21750661;25428506;27703206;29187734;29599122;30084848;30540948;34195786;34428180;34767585;34887587;8052633;8631802;9369227", "class_list": "", "function": "Effects of Importin alpha1/KPNA1 deletion and adolescent social isolation stress on psychiatric disorder-associated behaviors in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:8631802). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:8631802). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:8631802). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:8631802). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:8631802). Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with and Transportin-1/TNPO1 (By similarity)., [UniProtKB, UniProtKB, PubMed]; Importin alpha5 influences sphingosine-sensitive anxiety pathways by regulating MeCP2 nuclear import in hippocampal neurons., [RefSeq, PubMed]; Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TF32", "ec_number_list": [], "go_molecular_function": "GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0042981 regulation of apoptotic process;GO:0060828 regulation of canonical Wnt signaling pathway;GO:0006607 NLS-bearing protein import into nucleus;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q60960-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08992-1", "uniprot_id": [ { "id": "SDCB1_MOUSE", "url": "https://www.uniprot.org/uniprot/O08992", "type": "external" } ], "mass": 32379.0, "length": 299, "protein_name": "Syntenin-1", "gene_name": "Sdcbp", "organism": "Mouse", "refseq_name": "syntenin-1 isoform 1", "refseq_ac": [ { "id": "NP_001091697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091697", "type": "external" } ], "gene_names_uniprotkb": "Sdcbp", "gene_names_refseq": "MDA-9; Sdcbp; Sycl; syntenin-1", "protein_names_uniprotkb": "Syntenin-1; Scaffold protein Pbp1; Syndecan-binding protein 1", "protein_names_refseq": "scaffold protein Pbp1; syndecan interacting protein; syndecan-binding protein 1; syntenin-1 isoform 1; syntenin", "tax_id": 10090, "disease": "", "pathway": " (mmu:53378); (R-MMU-3928664); (R-MMU-447043); (R-MMU-5213460); (R-MMU-5675482); (R-MMU-6798695)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "21750661;22660413;25644602;26539120;31219806;36828627;36966820;37819151;38105293", "class_list": "glycogene", "function": "Downregulation of stromal syntenin sustains AML development., [RefSeq, PubMed]; Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis., [RefSeq, PubMed]; Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (By similarity). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (By similarity)., [UniProtKB, PubMed, UniProtKB]; PDZ interaction of the GABA transporter GAT1 with the syntenin-1 in Neuro-2a cells., [RefSeq, PubMed]; SDCBP promotes pancreatic cancer progression by preventing YAP1 from beta-TrCP-mediated proteasomal degradation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AKJ7;Q544P5", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0019838 growth factor binding;GO:0042802 identical protein binding;GO:0046875 ephrin receptor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0099054 presynapse assembly;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0030307 positive regulation of cell growth;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O08992-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C310-1", "uniprot_id": [ { "id": "ROBO4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C310", "type": "external" } ], "mass": 108499.0, "length": 1012, "protein_name": "Roundabout homolog 4", "gene_name": "Robo4", "organism": "Mouse", "refseq_name": "roundabout homolog 4 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001296319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296319", "type": "external" } ], "gene_names_uniprotkb": "Robo4", "gene_names_refseq": "1200012D01Rik; Robo4", "protein_names_uniprotkb": "Roundabout homolog 4", "protein_names_refseq": "Magic roundabout; roundabout homolog 4 isoform 1 precursor; roundabout homolog 4", "tax_id": 10090, "disease": "aortic valve disease 3 (Disease Ontology:DOID:0080977); pre-eclampsia (Disease Ontology:DOID:10591); transient cerebral ischemia (Disease Ontology:DOID:224); thyroid gland carcinoma (Disease Ontology:DOID:3963)", "pathway": " (mmu:74144)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;12941633;17496152;21183079;21750661;30455415;36647012;38762541;38937814", "class_list": "", "function": "Endothelial ROBO4 suppresses PTGS2/COX-2 expression and inflammatory diseases. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins. Involved in the maintenance of endothelial barrier organization and function (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Robo4 inhibits gamma radiation-induced permeability of a murine microvascular endothelial cell by regulating the junctions. Publication Status: Online-Only, [RefSeq, PubMed]; Robo4 is a bona fide member of the Robo family and may provide a repulsive cue to migrating endothelial cells during vascular development., [RefSeq, PubMed]; Robo4 mRNA level decreases during vascular decline in pulmonary fibrosis., [RefSeq, PubMed]; Slit2-Robo4 signal pathway and tight junction in intestine mediate LPS-induced inflammation in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 5, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q9DBW1", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0061028 establishment of endothelial barrier;GO:0001525 angiogenesis;GO:0030336 negative regulation of cell migration;GO:0098609 cell-cell adhesion;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8C310-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X9J0-1", "uniprot_id": [ { "id": "SI1L3_MOUSE", "url": "https://www.uniprot.org/uniprot/G3X9J0", "type": "external" } ], "mass": 195063.0, "length": 1776, "protein_name": "Signal-induced proliferation-associated 1-like protein 3", "gene_name": "Sipa1l3", "organism": "Mouse", "refseq_name": "signal-induced proliferation-associated 1-like protein 3", "refseq_ac": [ { "id": "NP_001074497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074497", "type": "external" } ], "gene_names_uniprotkb": "Sipa1l3; Spal3", "gene_names_refseq": "2610511M17Rik; Sipa1l3", "protein_names_uniprotkb": "Signal-induced proliferation-associated 1-like protein 3; SIPA1-like protein 3; SPA-1-like protein 3", "protein_names_refseq": "SIPA1-like protein 3; SPA-1-like protein 3; signal-induced proliferation-associated 1-like protein 3", "tax_id": 10090, "disease": "cataract 45 (Disease Ontology:DOID:0110262); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:74206)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;15592455;19144319;21183079;21750661;22645316;26231217;28951961;31219806;31599954;32848054;33725478;34428180;34887587;40885482", "class_list": "", "function": "Abnormalities of SIPA1L3 contribute to lens and eye defects, and we identify a critical role for SIPA1L3 in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization., [RefSeq, PubMed]; Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217)., [UniProtKB, PubMed]; To determine the impact of the truncated Sipa1l3 domains on eye development., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0045177 apical part of cell", "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:0007010 cytoskeleton organization;GO:0003382 epithelial cell morphogenesis;GO:0002244 hematopoietic progenitor cell differentiation;GO:0090162 establishment of epithelial cell polarity", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "G3X9J0-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26350-1", "uniprot_id": [ { "id": "PTMA_MOUSE", "url": "https://www.uniprot.org/uniprot/P26350", "type": "external" } ], "mass": 12254.0, "length": 111, "protein_name": "Prothymosin alpha", "gene_name": "Ptma", "organism": "Mouse", "refseq_name": "prothymosin alpha isoform 1", "refseq_ac": [ { "id": "NP_032998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032998", "type": "external" } ], "gene_names_uniprotkb": "Ptma", "gene_names_refseq": "Ptma; Thym", "protein_names_uniprotkb": "Prothymosin alpha", "protein_names_refseq": "prothymosin alpha isoform 1", "tax_id": 10090, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:19231)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "2015308;21750661;2226839;23806337;2479575;25605945;31219806;31759625;32782141;32817121;32909608;34428180;36766838;37507081", "class_list": "", "function": "Ggamma7-specific prothymosin alpha deletion causes stress- and age-dependent motor dysfunction and anxiety., [RefSeq, PubMed]; Prothymosin alpha Plays Role as a Brain Guardian through Ecto-F1 ATPase-P2Y12 Complex and TLR4/MD2. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Prothymosin alpha activates type I collagen to develop a fibrotic placenta in gestational diabetes., [RefSeq, PubMed]; Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Thymosin alpha1 protects from CTLA-4 intestinal immunopathology. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQV6", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0042393 histone binding;GO:0140297 DNA-binding transcription factor binding;GO:0140713 histone chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P26350-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46638-1", "uniprot_id": [ { "id": "RB11B_MOUSE", "url": "https://www.uniprot.org/uniprot/P46638", "type": "external" } ], "mass": 24489.0, "length": 218, "protein_name": "Ras-related protein Rab-11B", "gene_name": "Rab11b", "organism": "Mouse", "refseq_name": "ras-related protein Rab-11B", "refseq_ac": [ { "id": "NP_033023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033023", "type": "external" } ], "gene_names_uniprotkb": "Rab11b", "gene_names_refseq": "A730055L17Rik; Rab11b", "protein_names_uniprotkb": "Ras-related protein Rab-11B; 3.6.5.2", "protein_names_refseq": "RAS oncogene family protein; ras-related protein Rab-11B", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); intestinal cancer (Disease Ontology:DOID:10155)", "pathway": " (mmu:19326); (R-MMU-8854214); (R-MMU-8873719)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10942597;19335615;21291502;21750661;22129970;22935415;24463520;29514919;33300544;34428180;37424454;37507081;8001972", "class_list": "", "function": "RAB11A and RAB11B control mitotic spindle function in intestinal epithelial progenitor cells., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB25 regulates epithelial cell differentiation, proliferation and survival, thereby playing key roles in tumorigenesis. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0031489 myosin V binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0055037 recycling endosome;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0045054 constitutive secretory pathway;GO:0045055 regulated exocytosis;GO:0001881 receptor recycling;GO:0032456 endocytic recycling;GO:0032402 melanosome transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P46638-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80U23-1", "uniprot_id": [ { "id": "SNPH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80U23", "type": "external" } ], "mass": 53753.0, "length": 495, "protein_name": "Syntaphilin", "gene_name": "Snph", "organism": "Mouse", "refseq_name": "syntaphilin isoform b", "refseq_ac": [ { "id": "NP_001278005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278005", "type": "external" } ], "gene_names_uniprotkb": "Snph; Kiaa0374", "gene_names_refseq": "6430515A01; Snph; mKIAA0374", "protein_names_uniprotkb": "Syntaphilin", "protein_names_refseq": "syntaphilin isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:241727)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;18191227;19641106;21183079;21750661;23857772;36548516;37187340;40021952;40885482", "class_list": "", "function": "Here, we report a role for axon-targeted syntaphilin (SNPH) in mitochondrial docking through its interaction with microtubules. Axonal mitochondria that contain exogenously or endogenously expressed SNPH lose mobility., [RefSeq, PubMed]; Inhibits SNARE complex formation by absorbing free STX1A., [UniProtKB, UniProtKB]; Our studies suggest an unexpected role for LC8 and provide new mechanistic insights into how SNPH and LC8 together immobilize mitochondria through a dynamic interaction between the docking receptor and axonal cytoskeleton., [RefSeq, PubMed]; Roles of syntaphilin and armadillo repeat-containing X-linked protein 1 in brain injury after experimental intracerebral hemorrhage., [RefSeq, PubMed]; SNPH is required for activity-dependent regulation of mitochondrial transport., [RefSeq, PubMed]; Syntaphilin Regulates Neutrophil Migration in Cancer., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2AT08;A2AT09;A2AT10;A2AT11;A4FUV3;A4VCI7;Q4VA51;Q6GQX4;Q8C8B8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0043025 neuronal cell body;GO:0043005 neuron projection", "go_biological_process": "GO:0045806 negative regulation of endocytosis;GO:0030182 neuron differentiation;GO:0006906 vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q80U23-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35285-1", "uniprot_id": [ { "id": "RB22A_MOUSE", "url": "https://www.uniprot.org/uniprot/P35285", "type": "external" } ], "mass": 21802.0, "length": 194, "protein_name": "Ras-related protein Rab-22A", "gene_name": "Rab22a", "organism": "Mouse", "refseq_name": "ras-related protein Rab-22A", "refseq_ac": [ { "id": "NP_077756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077756", "type": "external" } ], "gene_names_uniprotkb": "Rab22a; Rab22", "gene_names_refseq": "3732413A17Rik; E130120E14Rik; Rab22a; Rab22", "protein_names_uniprotkb": "Ras-related protein Rab-22A; 3.6.5.2; Rab-14; Rab-22", "protein_names_refseq": "RAB22, member RAS oncogene family; rab-14; rab-22; ras-related protein Rab-22A", "tax_id": 10090, "disease": "", "pathway": " (mmu:19334); (R-MMU-8873719)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "1555775;16034420;19759177;21750661;26495903;27718357;27861124;30404817;34418053;36280710;8126105", "class_list": "", "function": "Findings provide compelling evidence that Rab22a plays a central role in the MHC-I endocytic trafficking, which is crucial for efficient cross-presentation by dendritic cells, [RefSeq, PubMed]; Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity., [RefSeq, PubMed]; Rab22A promotes the assembly of a BLOC-1-BLOC-2-KIF13A complex on early/sorting endosomes., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:19759177, PubMed:27718357). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB22A plays a role in endocytosis and intracellular protein transport (PubMed:19759177, PubMed:27718357). Mediates trafficking of transferrin/TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Has low GTPase activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UCA7;Q91VD4", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0012505 endomembrane system", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0007032 endosome organization;GO:0097494 regulation of vesicle size", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P35285-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35343-1", "uniprot_id": [ { "id": "IMA3_MOUSE", "url": "https://www.uniprot.org/uniprot/O35343", "type": "external" } ], "mass": 57923.0, "length": 521, "protein_name": "Importin subunit alpha-3", "gene_name": "Kpna4", "organism": "Mouse", "refseq_name": "importin subunit alpha-3", "refseq_ac": [ { "id": "NP_032493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032493", "type": "external" } ], "gene_names_uniprotkb": "Kpna4; Qip1", "gene_names_refseq": "1110058D08Rik; IPOA3; Kpna4; qip1", "protein_names_uniprotkb": "Importin subunit alpha-3; Importin alpha Q1; Karyopherin subunit alpha-4; Qip1", "protein_names_refseq": "importin alpha 3; importin alpha Q1; importin subunit alpha-3; importin subunit alpha-4; karyopherin (importin) alpha 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:16649)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;17242355;17654710;19710421;21183079;21750661;27703206;32792398;33300544;34428180;34887587;37134307;37507081;40997131;9369227", "class_list": "", "function": "Expression of importin alpha3, a protein involved in p50/p65 nuclear import, was decreased in colonic mucosa cells of transgenic mice overexpressing human prohibitin., [RefSeq, PubMed]; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of AARS1, MRTFA and RANBP3., [UniProtKB, UniProtKB]; Importin alpha3 regulates chronic pain pathways in peripheral sensory neurons., [RefSeq, PubMed]; In postnatal testes, importin alpha3 and alpha4 in spermatocytes, spermatids, and Sertoli cells display cytoplasmic and nuclear localization, respectively., [RefSeq, PubMed]; Inhibition of Importin- alpha -Mediated Nuclear Localization of Dendrin Attenuates Podocyte Loss and Glomerulosclerosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042542 response to hydrogen peroxide;GO:0035332 positive regulation of hippo signaling;GO:0010467 gene expression;GO:0006607 NLS-bearing protein import into nucleus;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "O35343-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09061-1", "uniprot_id": [ { "id": "PSB1_MOUSE", "url": "https://www.uniprot.org/uniprot/O09061", "type": "external" } ], "mass": 26372.0, "length": 240, "protein_name": "Proteasome subunit beta type-1", "gene_name": "Psmb1", "organism": "Mouse", "refseq_name": "proteasome subunit beta type-1", "refseq_ac": [ { "id": "NP_035315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035315", "type": "external" } ], "gene_names_uniprotkb": "Psmb1", "gene_names_refseq": "Lmpc5; Psmb1", "protein_names_uniprotkb": "Proteasome subunit beta type-1; Macropain subunit C5; Multicatalytic endopeptidase complex subunit C5; Proteasome component C5; Proteasome gamma chain; Proteasome subunit beta-6; beta-6", "protein_names_refseq": "beta-6; component C5 of proteasome; macropain subunit C5; multicatalytic endopeptidase complex subunit C5; proteasome beta-subunit C5; proteasome component C5; proteasome gamma chain; proteasome subunit C5; proteasome subunit beta type-1; proteasome subunit beta-6", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); intellectual disability (Disease Ontology:DOID:1059); microcephaly (Disease Ontology:DOID:10907); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:19170); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-6798695); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9912633); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 58, "publication_count": 13, "publication_id_list": "12525704;16581775;16857966;18034455;21750661;22341445;22556278;23018640;27768902;31219806;34428180;37507081;7579585", "class_list": "", "function": "Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB, UniProtKB]; Data indicate that treatment-emergent resistance to single-agent bortezomib was independent of variants in the proteasome genes PSMB1, PSMB5, PSMB6, PSMB8, PSMB9, and PSMB10., [RefSeq, PubMed]; Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; The P2Y2R enhances Ubiquitin-Proteasome System activity by increasing the subunits expression beta 5 and beta 1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q62038;Q62039", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0051603 proteolysis involved in protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O09061-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CT10-1", "uniprot_id": [ { "id": "RANB3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CT10", "type": "external" } ], "mass": 52573.0, "length": 491, "protein_name": "Ran-binding protein 3", "gene_name": "Ranbp3", "organism": "Mouse", "refseq_name": "ran-binding protein 3 isoform 2", "refseq_ac": [ { "id": "NP_082209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082209", "type": "external" } ], "gene_names_uniprotkb": "Ranbp3", "gene_names_refseq": "2610024N24Rik; Ranbp3", "protein_names_uniprotkb": "Ran-binding protein 3; RanBP3", "protein_names_refseq": "ran-binding protein 3 isoform 2; ran-binding protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:71810)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "17242355;19144319;21183079;21750661;21960005;23806337;25153642;25428506;28135057;28528544;30084848;35820727;40684658", "class_list": "", "function": "Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Protein phosphatase PPM1A regulates the nuclear export of Smad2/3 through targeting nuclear exporter RanBP3. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H6I9;Q3TIS4;Q3U2G4;Q3UYG7", "ec_number_list": [], "go_molecular_function": "GO:0070412 R-SMAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006611 protein export from nucleus;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9CT10-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99NE5-1", "uniprot_id": [ { "id": "RIMS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99NE5", "type": "external" } ], "mass": 163161.0, "length": 1463, "protein_name": "Regulating synaptic membrane exocytosis protein 1", "gene_name": "Rims1", "organism": "Mouse", "refseq_name": "regulating synaptic membrane exocytosis protein 1 isoform 1", "refseq_ac": [ { "id": "NP_444500", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444500", "type": "external" } ], "gene_names_uniprotkb": "Rims1; Kiaa0340; Rab3ip1; Rim1", "gene_names_refseq": "C030033M19Rik; RIM1alpha; RIM1a; RIM1; Rab3ip1; Rims1; Rim; Serg1", "protein_names_uniprotkb": "Regulating synaptic membrane exocytosis protein 1; RIM 1; Rab-3-interacting molecule 1; Rab-3-interacting protein 1", "protein_names_refseq": "Rab3 effector; Rab3 interacting protein 1; rab3-interacting molecule 1; regulating synaptic membrane exocytosis 1 beta; regulating synaptic membrane exocytosis protein 1 isoform 1; regulating synaptic membrane exocytosis protein 1; synaptic exocytosis regulator 1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:116837); (R-MMU-181429); (R-MMU-181430); (R-MMU-210500); (R-MMU-212676); (R-MMU-264642); (R-MMU-888590)", "pathway_count": 7, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;11431472;11797009;11797010;12578829;15543142;16452087;17114649;18799741;20164339;21183079;21750661;22645316;32848054;33300544;35820727;37159499;40885482", "class_list": "", "function": "CAMP-EPAC-PKCepsilon-RIM1alpha signaling regulates presynaptic long-term potentiation and motor learning. Publication Status: Online-Only, [RefSeq, PubMed]; RIM1alpha interacts with several active zone molecules, including Munc13-1 and alpha-liprins, to form a protein scaffold in the presynaptic nerve terminal., [RefSeq, PubMed]; Rab effector involved in exocytosis (PubMed:11797009). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (PubMed:11797009). Plays a role in dendrite formation by melanocytes (By similarity)., [UniProtKB, PubMed, UniProtKB]; Required for presynaptic long-term potentiation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5DU35;Q5J8K0;Q5J8K1;Q5J8K2;Q5J8K3;Q5J8K4", "ec_number_list": [], "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone;GO:0008270 zinc ion binding;GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0006886 intracellular protein transport;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation;GO:0042391 regulation of membrane potential", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q99NE5-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TCX3-1", "uniprot_id": [ { "id": "KHDC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TCX3", "type": "external" } ], "mass": 64563.0, "length": 612, "protein_name": "KH homology domain-containing protein 4", "gene_name": "Khdc4", "organism": "Mouse", "refseq_name": "KH homology domain-containing protein 4 isoform 1", "refseq_ac": [ { "id": "NP_083090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083090", "type": "external" } ], "gene_names_uniprotkb": "Khdc4; 2810403A07Rik; Blom7; Kiaa0907", "gene_names_refseq": "2810403A07Rik; A430106P18Rik; Blom7; Khdc4; Kiaa0907", "protein_names_uniprotkb": "KH homology domain-containing protein 4; Brings lots of money 7; Pre-mRNA splicing factor protein Khdc4", "protein_names_refseq": "KH homology domain-containing protein 4 isoform 1; KH homology domain-containing protein 4; brings lots of money 7; pre-mRNA splicing factor protein Khdc4; protein BLOM7", "tax_id": 10090, "disease": "", "pathway": " (mmu:74200)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;40997131", "class_list": "", "function": "RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site selection. Binds preferentially RNA with A/C rich sequences and poly-C stretches., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZW1;Q8BUQ0;Q923C9;Q9CZ63;Q9D207", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006376 mRNA splice site recognition;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3TCX3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXW3-1", "uniprot_id": [ { "id": "CYBP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXW3", "type": "external" } ], "mass": 26510.0, "length": 229, "protein_name": "Calcyclin-binding protein", "gene_name": "Cacybp", "organism": "Mouse", "refseq_name": "calcyclin-binding protein isoform 1", "refseq_ac": [ { "id": "NP_033916", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033916", "type": "external" } ], "gene_names_uniprotkb": "Cacybp; Sip", "gene_names_refseq": "Cacybp; SIP", "protein_names_uniprotkb": "Calcyclin-binding protein; CacyBP; Siah-interacting protein", "protein_names_refseq": "calcyclin-binding protein isoform 1; siah-interacting protein", "tax_id": 10090, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:12301)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;10884380;11927578;12042313;15996101;18803400;21540332;21750661;22645316;25153642;26085436;26495903;26740625;26873490;27180052;28135057;28283909;28528544;31219806;35820727;37507081;9572262", "class_list": "", "function": "Binds EF-hand proteins of the S100 family [CacyBP/SIP], [RefSeq, PubMed]; Calcyclin-binding protein/Siah-1-interacting protein (CacyBP/SIP) was initially described as a binding partner of S100A6 in the Ehrlich ascites tumor cells and later as a Siah-1-interacting protein. Its role has been studied in various mouse tumors and cell lines. Review. Review article, [RefSeq, PubMed]; In undifferentiated and differentiated tumor cells, CacyBP level has an effect on the ERK1/2-CREB-BDNF pathway., [RefSeq, PubMed]; Involvement of CacyBP/SIP in the regulation of p38 kinase activity, in addition to that of ERK1/2, might point to the function of CacyBP/SIP in pro-survival and pro-apoptotic pathways., [RefSeq, PubMed]; May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O70140", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding;GO:0044548 S100 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005641 nuclear envelope lumen;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007507 heart development;GO:1990830 cellular response to leukemia inhibitory factor;GO:0055007 cardiac muscle cell differentiation;GO:0060416 response to growth hormone;GO:0045740 positive regulation of DNA replication", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q9CXW3-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJV2-1", "uniprot_id": [ { "id": "PROF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJV2", "type": "external" } ], "mass": 15032.0, "length": 140, "protein_name": "Profilin-2", "gene_name": "Pfn2", "organism": "Mouse", "refseq_name": "profilin-2", "refseq_ac": [ { "id": "NP_062283", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062283", "type": "external" } ], "gene_names_uniprotkb": "Pfn2", "gene_names_refseq": "Pfn2; Pfn", "protein_names_uniprotkb": "Profilin-2; Profilin II", "protein_names_refseq": "profilin II; profilin-2", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:18645); (R-MMU-376176); (R-MMU-5663220)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "11027290;11034907;19403918;21750661;28135057;32522014;32788350;32839236;34571959;36788143;37507081;39927985", "class_list": "", "function": "Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG., [UniProtKB, UniProtKB, UniProtKB]; Circle RNA circABCB10 Modulates PFN2 to Promote Breast Cancer Progression, as Well as Aggravate Radioresistance Through Facilitating Glycolytic Metabolism Via miR-223-3p., [RefSeq, PubMed]; Maternal- and Fetal-Encoded Perforin-2 Limits Placental Infection by a Bloodborne Pathogen., [RefSeq, PubMed]; MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis., [RefSeq, PubMed]; Specificity and Redundancy of Profilin 1 and 2 Function in Brain Development and Neuronal Structure. Publication Status: Online-Only, [RefSeq, PubMed]; Upregulation of Profilin 2 on HDAC6 overexpression in mouse GC-1 cells and its putative role in germ cell migration in the testis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPT7;Q3V171;Q9ES48;Q9ES49;Q9ES50", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0003785 actin monomer binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0043195 terminal bouton", "go_biological_process": "GO:0010633 negative regulation of epithelial cell migration;GO:0098885 modification of postsynaptic actin cytoskeleton;GO:1900028 negative regulation of ruffle assembly;GO:0032233 positive regulation of actin filament bundle assembly;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9JJV2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXG3-1", "uniprot_id": [ { "id": "PPIL4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXG3", "type": "external" } ], "mass": 57230.0, "length": 492, "protein_name": "Peptidyl-prolyl cis-trans isomerase-like 4", "gene_name": "Ppil4", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase-like 4 isoform 1", "refseq_ac": [ { "id": "NP_080417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080417", "type": "external" } ], "gene_names_uniprotkb": "Ppil4", "gene_names_refseq": "3732410E19Rik; 3830425H19Rik; PPIase; Ppil4", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase-like 4; 5.2.1.8; Cyclophilin-like protein PPIL4; PPIase; Rotamase PPIL4", "protein_names_refseq": "cyclophilin-like protein PPIL4; peptidyl-prolyl cis-trans isomerase-like 4 isoform 1; peptidyl-prolyl cis-trans isomerase-like 4; rotamase PPIL4", "tax_id": 10090, "disease": "", "pathway": " (mmu:67418); (R-MMU-72163)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "16452087;19144319;21183079;21750661;25428506;25605945;26495903;28135057;28528544;30084848;34428180;35820727", "class_list": "", "function": "PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJX1;Q68FC7;Q9CT22", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005681 spliceosomal complex;GO:0071006 U2-type catalytic step 1 spliceosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9CXG3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31360-1", "uniprot_id": [ { "id": "PO3F2_MOUSE", "url": "https://www.uniprot.org/uniprot/P31360", "type": "external" } ], "mass": 47149.0, "length": 445, "protein_name": "POU domain, class 3, transcription factor 2", "gene_name": "Pou3f2", "organism": "Mouse", "refseq_name": "POU domain, class 3, transcription factor 2", "refseq_ac": [ { "id": "NP_032925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032925", "type": "external" } ], "gene_names_uniprotkb": "Pou3f2; Brn-2; Brn2; Otf7", "gene_names_refseq": "9430075J19Rik; A230098E07Rik; Brn-2; Brn2; OTF-7; Otf7; Pou3f2; oct-7", "protein_names_uniprotkb": "POU domain, class 3, transcription factor 2; Brain-2; Brain-specific homeobox/POU domain protein 2; Brn-2; Nervous system-specific octamer-binding transcription factor N-Oct-3; OTF-7; Oct-7; Octamer-binding protein 7; Octamer-binding transcription factor 7", "protein_names_refseq": "POU domain, class 3, transcription factor 2; brain-2 class III POU-domain protein; brain-specific homeobox/POU domain protein 2; nervous system-specific octamer-binding transcription factor N-Oct-3; octamer-binding protein 7; octamer-binding transcription factor 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:18992)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1565620;18403418;18505825;20107439;24243019;24643061;27281220", "class_list": "", "function": "Transcription factor that plays a key role in neuronal differentiation (PubMed:24243019). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (PubMed:18403418, PubMed:18505825). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (PubMed:20107439, PubMed:24243019, PubMed:27281220). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (PubMed:24243019)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AJY1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0021799 cerebral cortex radially oriented cell migration;GO:0021869 forebrain ventricular zone progenitor cell division;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P31360-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UYC0-1", "uniprot_id": [ { "id": "PPM1H_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UYC0", "type": "external" } ], "mass": 56380.0, "length": 513, "protein_name": "Protein phosphatase 1H", "gene_name": "Ppm1h", "organism": "Mouse", "refseq_name": "protein phosphatase 1H isoform 1", "refseq_ac": [ { "id": "NP_001103688", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103688", "type": "external" } ], "gene_names_uniprotkb": "Ppm1h; Kiaa1157", "gene_names_refseq": "A430075L18Rik; ARHCL1; C030002B11Rik; Ppm1h", "protein_names_uniprotkb": "Protein phosphatase 1H; 3.1.3.16", "protein_names_refseq": "protein phosphatase 1H isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:319468)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19144319;21183079;21750661;24129315;30084848;32600616", "class_list": "", "function": "Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation., [UniProtKB, UniProtKB]; Dual phosphorylation of protein phosphatase PPM1H promotes dephosphorylation of Smad1 in cellulo., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UD05;Q3V3H5;Q3V3Y7;Q571C9;Q7TMU7;Q8BYE6", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0004741 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity;GO:0042802 identical protein binding;GO:0004721 phosphoprotein phosphatase activity;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3UYC0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60953-1", "uniprot_id": [ { "id": "PML_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60953", "type": "external" } ], "mass": 98242.0, "length": 885, "protein_name": "Protein PML", "gene_name": "Pml", "organism": "Mouse", "refseq_name": "protein PML isoform 3", "refseq_ac": [ { "id": "NP_001298017", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298017", "type": "external" } ], "gene_names_uniprotkb": "Pml", "gene_names_refseq": "1200009E24Rik; Pml; Trim19", "protein_names_uniprotkb": "Protein PML", "protein_names_refseq": "probable transcription factor PML; protein PML isoform 3; protein PML", "tax_id": 10090, "disease": "acute promyelocytic leukemia (Disease Ontology:DOID:0060318); pre-eclampsia (Disease Ontology:DOID:10591); skin cancer (Disease Ontology:DOID:4159); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); hepatocellular carcinoma (Disease Ontology:DOID:684); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:18854); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-6804758); (R-MMU-8934593); (R-MMU-8948747)", "pathway_count": 6, "publication_count": 38, "publication_id_list": "10637504;10779416;11500381;11575918;11907221;12439746;12837286;14645235;14976551;15195100;15356634;16915281;17242355;18630941;19131326;19136970;19652541;21030605;21161613;21183079;21427174;21750661;21779477;22274616;22886304;23279884;23530056;25605945;26495903;29187734;30084848;30779550;34428180;38648485;39627609;8563172;9488655;9806545", "class_list": "", "function": "Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (By similarity). Positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Regulates phosphorylation of ITPR3 and plays a role in the regulation of calcium homeostasis at the endoplasmic reticulum. Regulates RB1 phosphorylation and activity. Acts as both a negative regulator of PPARGC1A acetylation and a potent activator of PPAR signaling and fatty acid oxidation. Regulates translation of HIF1A by sequestering MTOR, and thereby plays a role in neoangiogenesis and tumor vascularization. Regulates PER2 nuclear localization and circadian function. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. Required for normal development of the brain cortex during embryogenesis. Plays a role in granulopoiesis or monopoiesis of myeloid progenitor cells. May play a role regulating stem and progenitor cell fate in tissues as diverse as blood, brain and breast. Shows antiviral activity towards lymphocytic choriomeningitis virus (LCMV) and the vesicular stomatitis virus (VSV)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CEJ1;Q8VCC4", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1904816 positive regulation of protein localization to chromosome, telomeric region;GO:0044790 suppression of viral release by host;GO:0030578 PML body organization;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "Q60953-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZ13-1", "uniprot_id": [ { "id": "QCR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZ13", "type": "external" } ], "mass": 52852.0, "length": 480, "protein_name": "Cytochrome b-c1 complex subunit 1, mitochondrial", "gene_name": "Uqcrc1", "organism": "Mouse", "refseq_name": "cytochrome b-c1 complex subunit 1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_079683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079683", "type": "external" } ], "gene_names_uniprotkb": "Uqcrc1", "gene_names_refseq": "1110032G10Rik; Uqcrc1", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 1, mitochondrial; Complex III subunit 1; Core protein I; Ubiquinol-cytochrome-c reductase complex core protein 1", "protein_names_refseq": "complex III subunit 1; core protein I; cytochrome b-c1 complex subunit 1, mitochondrial precursor; cytochrome b-c1 complex subunit 1, mitochondrial; ubiquinol-cytochrome-c reductase complex core protein 1", "tax_id": 10090, "disease": "multiple mitochondrial dysfunctions syndrome 6 (Disease Ontology:DOID:0070332); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:22273); (R-MMU-611105); (R-MMU-9865881)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "19026783;21750661;22645316;23576753;23806337;25428506;30084848;30666338;32161263;33300544;34428180;34616041;34648372;35820727;36288343;37453647;37507081;38575788;39927985;40684658", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation (PubMed:34616041, PubMed:38575788). The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase (PubMed:34616041, PubMed:38575788). The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties. May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (By similarity). Seems to play an important role in the maintenance of proper mitochondrial function in nigral dopaminergic neurons (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Ubiquinol-cytochrome c reductase core protein 1 contributes to cardiac tolerance to acute exhaustive exercise., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TV75;Q9CWL6", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0043209 myelin sheath;GO:0045275 respiratory chain complex III;GO:0017087 mitochondrial processing peptidase complex", "go_biological_process": "GO:0043279 response to alkaloid;GO:0014823 response to activity;GO:0006627 protein processing involved in protein targeting to mitochondrion;GO:0034551 mitochondrial respiratory chain complex III assembly;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9CZ13-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PUL5-1", "uniprot_id": [ { "id": "PRRT2_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PUL5", "type": "external" } ], "mass": 35924.0, "length": 346, "protein_name": "Proline-rich transmembrane protein 2", "gene_name": "Prrt2", "organism": "Mouse", "refseq_name": "proline-rich transmembrane protein 2", "refseq_ac": [ { "id": "NP_001096033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096033", "type": "external" } ], "gene_names_uniprotkb": "Prrt2", "gene_names_refseq": "1500031I19Rik; DSPB3; Prrt2", "protein_names_uniprotkb": "Proline-rich transmembrane protein 2; DSPB3; Dispanin subfamily B member 3", "protein_names_refseq": "dispanin subfamily B member 3; proline-rich transmembrane protein 2", "tax_id": 10090, "disease": "benign familial infantile seizures 2 (Disease Ontology:DOID:0081115); episodic kinesigenic dyskinesia 1 (Disease Ontology:DOID:0090053)", "pathway": " (mmu:69017)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "21183079;21750661;22101681;22243967;22363774;22632720;22832103;24129315;25915028;26797119;27052163;27172900;28007585;29056747;32848054;34678516;37793168", "class_list": "", "function": "As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing (PubMed:27052163). In the cerebellum, may inhibit SNARE complex formation and down-regulate short-term facilitation (PubMed:29056747)., [UniProtKB, PubMed, PubMed]; Mutants associated with paroxysmal kinesigenic dyskinesia with infantile convulsions C lead to dramatically reduced PRRT2 levels., [RefSeq, PubMed]; PRRT2 interacts with the Src homology 3 domain-bearing protein Intersectin 1, an intracellular protein involved in synaptic vesicle cycling. Erratum:[J Biol Chem. 2018 Mar 23;293(12):4581. doi: 10.1074/jbc.AAC118.002651. PMID: 29572331], [RefSeq, PubMed]; Proline-rich transmembrane protein 2 knock-in mice present dopamine-dependent motor deficits., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0017075 syntaxin-1 binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043197 dendritic spine;GO:0043679 axon terminus", "go_biological_process": "GO:0035544 negative regulation of SNARE complex assembly;GO:0050884 neuromuscular process controlling posture;GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane;GO:1905513 negative regulation of short-term synaptic potentiation;GO:0150037 regulation of calcium-dependent activation of synaptic vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "E9PUL5-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35822-1", "uniprot_id": [ { "id": "PTPRK_MOUSE", "url": "https://www.uniprot.org/uniprot/P35822", "type": "external" } ], "mass": 164186.0, "length": 1457, "protein_name": "Receptor-type tyrosine-protein phosphatase kappa", "gene_name": "Ptprk", "organism": "Mouse", "refseq_name": "receptor-type tyrosine-protein phosphatase kappa isoform 2 precursor", "refseq_ac": [ { "id": "NP_033009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033009", "type": "external" } ], "gene_names_uniprotkb": "Ptprk; Ptpk", "gene_names_refseq": "PTPk; Ptprk; RPTPkappa", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase kappa; 3.1.3.48; Protein-tyrosine phosphatase kappa; R-PTP-kappa", "protein_names_refseq": "R-PTP-kappa; protein-tyrosine phosphatase kappa; receptor-type tyrosine-protein phosphatase kappa isoform 2 precursor; receptor-type tyrosine-protein phosphatase kappa", "tax_id": 10090, "disease": "", "pathway": " (mmu:19272); (R-MMU-182971)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;19349973;21183079;21750661;25428506;30084848;30899004;34428180;37828378;8474452", "class_list": "", "function": "Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 10, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0008013 beta-catenin binding;GO:0045295 gamma-catenin binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0009986 cell surface;GO:0030054 cell junction;GO:0030424 axon", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0008285 negative regulation of cell population proliferation;GO:0016477 cell migration;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P35822-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7M6Z0-1", "uniprot_id": [ { "id": "R4RL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7M6Z0", "type": "external" } ], "mass": 46075.0, "length": 420, "protein_name": "Reticulon-4 receptor-like 2", "gene_name": "Rtn4rl2", "organism": "Mouse", "refseq_name": "reticulon-4 receptor-like 2 precursor", "refseq_ac": [ { "id": "NP_954693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954693", "type": "external" } ], "gene_names_uniprotkb": "Rtn4rl2; Ngrl3", "gene_names_refseq": "Ngr2; Ngrh1; Ngrl3; Rtn4rl2", "protein_names_uniprotkb": "Reticulon-4 receptor-like 2; NgR2; Nogo receptor-like 3; Nogo-66 receptor homolog 1; Nogo-66 receptor-related protein 2", "protein_names_refseq": "nogo receptor-like 3; nogo-66 receptor homolog 1; nogo-66 receptor-related protein 2; reticulon-4 receptor-like 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:269295); (R-MMU-163125)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12839991;14664809;15673660;19367338;21750661;22325200;22406547;26335717;27339102", "class_list": "", "function": "Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development (PubMed:27339102). Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum (PubMed:27339102). Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system (PubMed:22406547). Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (PubMed:26335717). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Predominantly expressed in the neurons of the embryonic and adult nervous systems, [RefSeq, PubMed]; Sensory neurons deficient for both NgR proteins displayed only a moderate reduction of MAG-mediated inhibition of neurite growth., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2RTJ0;Q3UQ62", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0010977 negative regulation of neuron projection development;GO:0051965 positive regulation of synapse assembly;GO:0022038 corpus callosum development;GO:0031103 axon regeneration", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q7M6Z0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DD03-1", "uniprot_id": [ { "id": "RAB13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DD03", "type": "external" } ], "mass": 22770.0, "length": 202, "protein_name": "Ras-related protein Rab-13", "gene_name": "Rab13", "organism": "Mouse", "refseq_name": "ras-related protein Rab-13 isoform 1", "refseq_ac": [ { "id": "NP_080953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080953", "type": "external" } ], "gene_names_uniprotkb": "Rab13", "gene_names_refseq": "0610007N03Rik; B230212B15Rik; Rab13", "protein_names_uniprotkb": "Ras-related protein Rab-13; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-13 isoform 1; ras-related protein Rab-13", "tax_id": 10090, "disease": "Smith-McCort dysplasia (Disease Ontology:DOID:0060247); Dyggve-Melchior-Clausen disease (Disease Ontology:DOID:0111167)", "pathway": " (mmu:68328); (R-MMU-8873719); (R-MMU-8876198)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "16525024;20360680;21543326;21750661;25428506;33300544;33976349;36633475;37828378", "class_list": "", "function": "Exosomal proteomics identifies RAB13 as a potential regulator of metastasis for HCC. Publication Status: Online-Only, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB13 is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0031175 neuron projection development;GO:0032869 cellular response to insulin stimulus;GO:0072659 protein localization to plasma membrane;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9DD03-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUB3-1", "uniprot_id": [ { "id": "PYGM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUB3", "type": "external" } ], "mass": 97286.0, "length": 842, "protein_name": "Glycogen phosphorylase, muscle form", "gene_name": "Pygm", "organism": "Mouse", "refseq_name": "glycogen phosphorylase, muscle form", "refseq_ac": [ { "id": "NP_035354", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035354", "type": "external" } ], "gene_names_uniprotkb": "Pygm", "gene_names_refseq": "PG; Pygm", "protein_names_uniprotkb": "Glycogen phosphorylase, muscle form; 2.4.1.1; Myophosphorylase", "protein_names_refseq": "glycogen phosphorylase, muscle form; myophosphorylase", "tax_id": 10090, "disease": "cholestasis (Disease Ontology:DOID:13580); glycogen storage disease V (Disease Ontology:DOID:2746); glycogen storage disease (Disease Ontology:DOID:2747)", "pathway": " (mmu:19309); (R-MMU-70221)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10318868;18034455;21183079;21750661;25428506;30084848;30779550;33300544;33725478;34428180;35984892;36288343;37507081;37537141;37828378;39927985;40684658", "class_list": "glycogene;glycosyltransferase", "function": "Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Long-term potentiation-based screening identifies neuronal PYGM as a synaptic plasticity regulator participating in Alzheimer's disease., [RefSeq, PubMed]; This gene encodes a glycolysis enzyme found in muscle. Highly similar enzymes encoded by different genes are found in liver and brain. The encoded protein is involved in regulating the breakdown of glycogen to glucose-1-phosphate, which is necessary for ATP generation. [provided by RefSeq, Dec 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 38, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0016208 AMP binding;GO:0030246 carbohydrate binding;GO:0008184 glycogen phosphorylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030018 Z disc;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0001666 response to hypoxia;GO:0005977 glycogen metabolic process;GO:0006874 intracellular calcium ion homeostasis;GO:0051591 response to cAMP;GO:0005980 glycogen catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9WUB3-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05920-1", "uniprot_id": [ { "id": "PYC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q05920", "type": "external" } ], "mass": 129685.0, "length": 1178, "protein_name": "Pyruvate carboxylase, mitochondrial", "gene_name": "Pcx; Pc", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pcx; Pc; Pcx", "gene_names_refseq": "", "protein_names_uniprotkb": "Pyruvate carboxylase, mitochondrial; 6.4.1.1; PCB; Pyruvic carboxylase", "protein_names_refseq": "", "tax_id": 10090, "disease": "pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649); pyruvate carboxylase deficiency disease (Disease Ontology:DOID:3651)", "pathway": " (mmu:18563); (R-MMU-196780); (R-MMU-70263); (R-MMU-70268)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "17242355;21750661;22645316;23438705;23576753;23806337;30084848;33300544;34428180;35984892;36064721;37453647;37507081;39627609;39927985;8446588", "class_list": "glycogene", "function": "Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second., [UniProtKB, UniProtKB, UniProtKB]; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 45, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.1", "type": "external" }, { "id": "6.4.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.4", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "6.3.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.-", "type": "external" }, { "id": "6.3.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.10", "type": "external" }, { "id": "6.3.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.11", "type": "external" }, { "id": "6.3.4.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.15", "type": "external" }, { "id": "6.3.4.9", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.9", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004736 pyruvate carboxylase activity;GO:0042802 identical protein binding;GO:0009374 biotin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006094 gluconeogenesis;GO:0006739 NADP+ metabolic process;GO:0019074 viral RNA genome packaging;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q05920-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0100000001001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15919-1", "uniprot_id": [ { "id": "RAG1_MOUSE", "url": "https://www.uniprot.org/uniprot/P15919", "type": "external" } ], "mass": 119185.0, "length": 1040, "protein_name": "V(D)J recombination-activating protein 1", "gene_name": "Rag1", "organism": "Mouse", "refseq_name": "V(D)J recombination-activating protein 1", "refseq_ac": [ { "id": "NP_033045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033045", "type": "external" } ], "gene_names_uniprotkb": "Rag1", "gene_names_refseq": "Rag-1; Rag1", "protein_names_uniprotkb": "V(D)J recombination-activating protein 1; RAG-1; RING-type E3 ubiquitin transferase RAG1", "protein_names_refseq": "V(D)J recombination-activating protein 1; recombinase activating gene 1; recombination activating gene 1; recombination activating protein 1", "tax_id": 10090, "disease": "Omenn syndrome (Disease Ontology:DOID:0060010); severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive (Disease Ontology:DOID:0090013); combined cellular and humoral immune defects with granulomas (Disease Ontology:DOID:0112253); hypertension (Disease Ontology:DOID:10763); severe combined immunodeficiency (Disease Ontology:DOID:627)", "pathway": " (mmu:19373)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10601032;10601033;10678172;12629039;14671314;1547488;17028591;19118899;19396172;19448632;19524534;20122409;22157821;2598259;36210013;8284210;8521468;9094713;9184213;9228952", "class_list": "", "function": "Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In addition to its endonuclease activity, RAG1 also acts as an E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3. Histone H3 monoubiquitination is required for the joining step of V(D)J recombination. Mediates polyubiquitination of KPNA1., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 48, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AVN8", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0097519 DNA recombinase complex;GO:1905347 endodeoxyribonuclease complex", "go_biological_process": "GO:0006310 DNA recombination;GO:0008542 visual learning;GO:0070244 negative regulation of thymocyte apoptotic process;GO:0002250 adaptive immune response;GO:0045580 regulation of T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P15919-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35295-1", "uniprot_id": [ { "id": "RAB20_MOUSE", "url": "https://www.uniprot.org/uniprot/P35295", "type": "external" } ], "mass": 25989.0, "length": 233, "protein_name": "Ras-related protein Rab-20", "gene_name": "Rab20", "organism": "Mouse", "refseq_name": "ras-related protein Rab-20", "refseq_ac": [ { "id": "NP_035357", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035357", "type": "external" } ], "gene_names_uniprotkb": "Rab20", "gene_names_refseq": "D8Ertd350e; Rab20", "protein_names_uniprotkb": "Ras-related protein Rab-20; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-20", "tax_id": 10090, "disease": "", "pathway": " (mmu:19332); (R-MMU-8873719)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1555775;25269936;34428180;7706395", "class_list": "", "function": "Inpp5e, through functional interactions with Rab20 on the phagosome, activates Rab5, which, in turn, increases PtdIns3P and delays phagosome acidification., [RefSeq, PubMed]; Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays a role in the fusion of phagosomes with lysosomes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:0090383 phagosome acidification;GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0071346 cellular response to type II interferon;GO:0090385 phagosome-lysosome fusion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P35295-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70698-1", "uniprot_id": [ { "id": "PYRG1_MOUSE", "url": "https://www.uniprot.org/uniprot/P70698", "type": "external" } ], "mass": 66682.0, "length": 591, "protein_name": "CTP synthase 1", "gene_name": "Ctps1", "organism": "Mouse", "refseq_name": "CTP synthase 1", "refseq_ac": [ { "id": "NP_058028", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058028", "type": "external" } ], "gene_names_uniprotkb": "Ctps1; Ctps", "gene_names_refseq": "Ctps1; Ctps", "protein_names_uniprotkb": "CTP synthase 1; 3.5.1.-; 6.3.4.2; CTP synthetase 1; Protein-asparagine deamidase CTPS1; UTP--ammonia ligase 1", "protein_names_refseq": "CTP synthase 1; CTP synthetase 1; UTP--ammonia ligase 1; protein-asparagine deamidase CTPS1", "tax_id": 10090, "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); immunodeficiency 24 (Disease Ontology:DOID:0111938)", "pathway": " (mmu:51797); (R-MMU-499943)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "17242355;21183079;21952136;22730407;24008161;25153642;25223282;25428506;25428507;25605945;28135057;28528544;30084848;30779550;31219806;34428180;34583994;37507081;38438357;39627609;39719712", "class_list": "", "function": "CTP synthase involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids (PubMed:38438357). Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen (By similarity). CTPS1 CTP synthase activity plays a crucial role in the proliferation of activated lymphocytes and immunity; additional CTP being required to meet increased demand for DNA, RNA and lipid membrane biosynthesis in proliferating lymphocytes (PubMed:38438357). In addition to CTP synthase activity, also acts as a protein deamidase that catalyzes the side chain deamidation of specific asparagine residues of proteins to aspartate (PubMed:39719712). Acts as a negative regulator of innate immunity by mediating deamidation of 'Asn-85' of IRF3, preventing IRF3 from binding DNA (PubMed:39719712). Facilitates chromatin relaxation in response to DNA damage by mediating deamidation of 'Asn-76' and 'Asn-77' of histone H1, thereby promoting subsequent acetylation of histone H1 at 'Lys-75' (H1K75ac), increasing chromatin accessibility to facilitate the recruitment of DNA repair proteins (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; CTPS1 inhibition selectively blocks smooth muscle cell proliferation without disturbing or even promoting re-endothelialization for effective vascular repair after injury., [RefSeq, PubMed]; Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q922Y4", "ec_number_list": [ { "id": "6.3.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.2", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0003883 CTP synthase activity;GO:0160260 protein asparagine deamidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin;GO:0097268 cytoophidium", "go_biological_process": "GO:1902340 negative regulation of chromosome condensation;GO:0044210 'de novo' CTP biosynthetic process;GO:0042100 B cell proliferation;GO:0042098 T cell proliferation;GO:0032480 negative regulation of type I interferon production", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P70698-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69ZS0-1", "uniprot_id": [ { "id": "PZRN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69ZS0", "type": "external" } ], "mass": 119401.0, "length": 1063, "protein_name": "E3 ubiquitin-protein ligase PDZRN3", "gene_name": "Pdzrn3", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase PDZRN3", "refseq_ac": [ { "id": "NP_061372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061372", "type": "external" } ], "gene_names_uniprotkb": "Pdzrn3; Kiaa1095; Semcap3", "gene_names_refseq": "1110020C07Rik; LNX3; Pdzrn3; SEMACAP3; Semcap3", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase PDZRN3; 2.3.2.27; PDZ domain-containing RING finger protein 3; Protein SEMACAP3; RING-type E3 ubiquitin transferase PDZRN3; Semaphorin cytoplasmic domain-associated protein 3", "protein_names_refseq": "E3 ubiquitin-protein ligase PDZRN3; PDZ domain containing RING finger 3A; PDZ domain-containing RING finger protein 3; RING-type E3 ubiquitin transferase PDZRN3; semaphorin cytoplasmic domain-associated protein 3A", "tax_id": 10090, "disease": "", "pathway": " (mmu:55983)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17118964;17576800;21183079;21750661;31599954;32848054;34996942;38471344", "class_list": "", "function": "Decrease of Pdzrn3 is required for heart maturation and protects against heart failure. Publication Status: Online-Only, [RefSeq, PubMed]; E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation., [UniProtKB, PubMed, PubMed]; Granulysin-mediated reduction of PDZRN3 induces Cx43 gap junctions activity exacerbating skin damage in trichloroethylene hypersensitivity syndrome., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q91Z03;Q9QY54;Q9QY55", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0007528 neuromuscular junction development;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q69ZS0-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P1I6-1", "uniprot_id": [ { "id": "PSD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P1I6", "type": "external" } ], "mass": 84299.0, "length": 770, "protein_name": "PH and SEC7 domain-containing protein 2", "gene_name": "Psd2", "organism": "Mouse", "refseq_name": "PH and SEC7 domain-containing protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001276531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276531", "type": "external" } ], "gene_names_uniprotkb": "Psd2; Efa6c", "gene_names_refseq": "6330404E20Rik; EFA6C; Psd2", "protein_names_uniprotkb": "PH and SEC7 domain-containing protein 2; Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C; Exchange factor for ARF6 C; Pleckstrin homology and SEC7 domain-containing protein 2", "protein_names_refseq": "PH and SEC7 domain-containing protein 2 isoform 2; PH and SEC7 domain-containing protein 2; exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C; exchange factor for ARF6 C; pleckstrin homology and SEC7 domain-containing protein 2", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:74002)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;23603394;31095630", "class_list": "", "function": "EFA6C, a guanine nucleotide exchange factor for Arf6, plays ancillary roles in cerebellar development and motor functions Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NZP0;Q6PHQ7;Q8BHR9;Q9D3B8", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0098794 postsynapse;GO:0032154 cleavage furrow", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0032012 regulation of ARF protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6P1I6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PHN9-1", "uniprot_id": [ { "id": "RAB35_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PHN9", "type": "external" } ], "mass": 23025.0, "length": 201, "protein_name": "Ras-related protein Rab-35", "gene_name": "Rab35", "organism": "Mouse", "refseq_name": "ras-related protein Rab-35", "refseq_ac": [ { "id": "NP_937806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_937806", "type": "external" } ], "gene_names_uniprotkb": "Rab35", "gene_names_refseq": "9530019H02Rik; H-ray; RAB1C; RAY; Rab35", "protein_names_uniprotkb": "Ras-related protein Rab-35; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-35", "tax_id": 10090, "disease": "", "pathway": " (mmu:77407); (R-MMU-8854214); (R-MMU-8873719); (R-MMU-8876198)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "20159556;21750661;22762500;23572513;26774822;29125462;30150626;33033331;33300544;33880375;34428180;37085665", "class_list": "", "function": "MiR-720 Regulates Insulin Secretion by Targeting Rab35. Publication Status: Online-Only, [RefSeq, PubMed]; RAB35 is required for murine hippocampal development and functions by regulating neuronal cell distribution. Publication Status: Online-Only, [RefSeq, PubMed]; Rab35 and its effectors promote formation of tunneling nanotubes in neuronal cells. Publication Status: Online-Only, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:20159556, PubMed:22762500). RAB35 is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane (PubMed:20159556). During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge (By similarity). May indirectly regulate neurite outgrowth (PubMed:23572513). Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes (PubMed:22762500)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0046872 metal ion binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0042470 melanosome;GO:0045171 intercellular bridge", "go_biological_process": "GO:0015031 protein transport;GO:0031175 neuron projection development;GO:1990090 cellular response to nerve growth factor stimulus;GO:0016197 endosomal transport;GO:0036010 protein localization to endosome", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q6PHN9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGC4-1", "uniprot_id": [ { "id": "PTGR3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGC4", "type": "external" } ], "mass": 40529.0, "length": 377, "protein_name": "Prostaglandin reductase-3", "gene_name": "Ptgr3", "organism": "Mouse", "refseq_name": "prostaglandin reductase-3 isoform 1", "refseq_ac": [ { "id": "NP_666202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666202", "type": "external" } ], "gene_names_uniprotkb": "Ptgr3; Zadh2", "gene_names_refseq": "C530046K17Rik; PTGR-3; Ptgr3; Pthr3; Zadh2", "protein_names_uniprotkb": "Prostaglandin reductase-3; 1.3.1.48; 15-oxoprostaglandin 13-reductase; PTGR-3; Zinc-binding alcohol dehydrogenase domain-containing protein 2", "protein_names_refseq": "15-oxoprostaglandin 13-reductase; prostaglandin reductase-3 isoform 1; zinc binding alcohol dehydrogenase, domain containing 2; zinc-binding alcohol dehydrogenase domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:225791)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19091015;21750661;23576753;23821743;31219806;34428180;37507081", "class_list": "", "function": "Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation., [UniProtKB, PubMed]; PTGR-3 is a novel 15-oxoprostaglandin-Delta(13)-reductase that plays a critical role in modulation of normal adipocyte differentiation via regulation of PPARgamma activity [PTGR3], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.48", "type": "external" }, { "id": "1.3.1.74", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.74", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0047522 15-oxoprostaglandin 13-reductase [NAD(P)+] activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0045599 negative regulation of fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BGC4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0J8-1", "uniprot_id": [ { "id": "PTMS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0J8", "type": "external" } ], "mass": 11430.0, "length": 101, "protein_name": "Parathymosin", "gene_name": "Ptms", "organism": "Mouse", "refseq_name": "parathymosin", "refseq_ac": [ { "id": "NP_081264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081264", "type": "external" } ], "gene_names_uniprotkb": "Ptms", "gene_names_refseq": "2610009E16Rik; Ptms", "protein_names_uniprotkb": "Parathymosin", "protein_names_refseq": "parathymosin", "tax_id": 10090, "disease": "", "pathway": " (mmu:69202)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21750661;23806337;34428180;35820727", "class_list": "", "function": "Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D0J8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ET01-1", "uniprot_id": [ { "id": "PYGL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ET01", "type": "external" } ], "mass": 97463.0, "length": 850, "protein_name": "Glycogen phosphorylase, liver form", "gene_name": "Pygl", "organism": "Mouse", "refseq_name": "glycogen phosphorylase, liver form", "refseq_ac": [ { "id": "NP_573461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573461", "type": "external" } ], "gene_names_uniprotkb": "Pygl", "gene_names_refseq": "Pygl", "protein_names_uniprotkb": "Glycogen phosphorylase, liver form; 2.4.1.1", "protein_names_refseq": "glycogen phosphorylase, liver form", "tax_id": 10090, "disease": "glycogen storage disease (Disease Ontology:DOID:2747); glycogen storage disease VI (Disease Ontology:DOID:2754); lactic acidosis (Disease Ontology:DOID:3650)", "pathway": " (mmu:110095); (R-MMU-6798695); (R-MMU-70221)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "20173027;21183079;23806337;34428180;37453647;37507081", "class_list": "glycogene;glycosyltransferase", "function": "Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 41, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKJ0", "ec_number_list": [ { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", 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"https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0019842 vitamin binding;GO:0005524 ATP binding;GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0016208 AMP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0005977 glycogen metabolic process;GO:0009617 response to bacterium;GO:0042593 glucose homeostasis;GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process;GO:0070266 necroptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9ET01-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHG7-1", "uniprot_id": [ { "id": "RPGF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHG7", "type": "external" } ], "mass": 166415.0, "length": 1496, "protein_name": "Rap guanine nucleotide exchange factor 2", "gene_name": "Rapgef2", "organism": "Mouse", "refseq_name": "rap guanine nucleotide exchange factor 2 isoform 2", "refseq_ac": [ { "id": "NP_001297465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297465", "type": "external" } ], "gene_names_uniprotkb": "Rapgef2; Kiaa0313; Pdzgef1", "gene_names_refseq": "5830453M24Rik; CNRasGEF; Pdzgef1; RA-GEF-1; Rapgef2; mKIAA0313; nRapGEP", "protein_names_uniprotkb": "Rap guanine nucleotide exchange factor 2; CNrasGEF; Cyclic nucleotide ras GEF; Neural RAP guanine nucleotide exchange protein; PDZ domain-containing guanine nucleotide exchange factor 1; PDZ-GEF1; RA-GEF-1; Ras/Rap1-associating GEF-1; nRap GEP", "protein_names_refseq": "PDZ domain-containing guanine nucleotide exchange factor 1; cyclic nucleotide ras GEF; neural RAP guanine nucleotide exchange protein; rap guanine nucleotide exchange factor 2 isoform 2; rap guanine nucleotide exchange factor 2; ras/Rap1-associating GEF-1", "tax_id": 10090, "disease": "familial adult myoclonic epilepsy 7 (Disease Ontology:DOID:0111694)", "pathway": " (mmu:76089); (R-MMU-5673001)", "pathway_count": 2, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;16272156;16452087;17242355;17826737;19144319;19453629;19635461;20173027;21183079;21750661;21864586;22517741;22645316;23800469;30059200;31219806;32782141;32848054;33345400;34428180;34678516;36852467;38236296;40021952;40885482", "class_list": "", "function": "CNrasGEF regulates melanogenesis but that it also has a distinct role in regulating cell proliferation/apoptosis, [RefSeq, PubMed]; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; RAPGEF2 mediates oligomeric Abeta-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer's disease., [RefSeq, PubMed]; The guanine nucleotide exchange factor RapGEF2 is required for ERK-dependent immediate-early gene (Egr1) activation during fear memory formation. Publication Status: Online-Only, [RefSeq, PubMed]; These results suggest that deficient Rap1 signaling may lead to defective vascular morphogenesis in the yolk sac and embryos proper., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 17, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 17, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 17, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "E9QMD0", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0019901 protein kinase binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0050699 WW domain binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0048022 negative regulation of melanin biosynthetic process;GO:0061028 establishment of endothelial barrier;GO:0032486 Rap protein signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "Q8CHG7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UJU9-1", "uniprot_id": [ { "id": "RMD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UJU9", "type": "external" } ], "mass": 52029.0, "length": 470, "protein_name": "Regulator of microtubule dynamics protein 3", "gene_name": "Rmdn3", "organism": "Mouse", "refseq_name": "regulator of microtubule dynamics protein 3", "refseq_ac": [ { "id": "NP_001028308", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028308", "type": "external" } ], "gene_names_uniprotkb": "Rmdn3; Fam82a2; Fam82c", "gene_names_refseq": "1200015F23Rik; Fam82a2; Ptpip51; RMD-3; Rmd3; Rmdn3", "protein_names_uniprotkb": "Regulator of microtubule dynamics protein 3; Protein FAM82A2; Protein FAM82C; RMD-3; mRMD-3", "protein_names_refseq": "family with sequence similarity 82, member A2; microtubule-associated protein; protein tyrosine phosphatase-interacting protein 51; regulator of microtubule dynamics protein 3; tyrosine phosphatase interacting protein 51", "tax_id": 10090, "disease": "", "pathway": " (mmu:67809)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "17208939;17242355;18070910;18084773;18630941;19144319;19372376;19844996;21183079;21266951;21750661;23533724;25496818;28345618;33300544;35820727;37453647", "class_list": "", "function": "Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~79%., [RefSeq, PubMed]; Involved in cellular calcium homeostasis regulation (By similarity). May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis (By similarity)., [UniProtKB]; PTPIP51 as a therapeutic target for ischemic heart diseases. Publication Status: Online-Only, [RefSeq, PubMed]; PTPIP51(protein tyrosine phosphatase interacting protein 51) might serve as a linking protein in adipocyte metabolism by connecting the insulin receptor-triggered lipogenesis with the protein kinase A-dependent lipolysis., [RefSeq, PubMed]; Protein interaction profile of PTPIP51 suggests a role in the memory formation in the hippocampus and cerebellum., [RefSeq, PubMed]; The PTPIP51 was integrated in signaling cascades regulating differentiation and apoptosis during eye development., [RefSeq, PubMed]; The data presented here suggest a role of PTPIP51 in neuronal homeostasis, axonal growth, and transport., [RefSeq, PubMed]; The interaction of PTPIP51 with 14-3-3beta, especially in trained individuals, hints to an involvement of PTPIP51 in the downstream regulation of insulin action., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9UN03;Q3U5Y8;Q3UB61;Q6P8M2;Q7TNF2", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044232 organelle membrane contact site;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0030154 cell differentiation;GO:0006874 intracellular calcium ion homeostasis;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q3UJU9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESG2-1", "uniprot_id": [ { "id": "ROP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ESG2", "type": "external" } ], "mass": 24003.0, "length": 212, "protein_name": "Ropporin-1", "gene_name": "Ropn1", "organism": "Mouse", "refseq_name": "ropporin-1", "refseq_ac": [ { "id": "NP_109669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109669", "type": "external" } ], "gene_names_uniprotkb": "Ropn1", "gene_names_refseq": "1700008N21Rik; ODF6; RHPNAP1; Ropn1; Rppn; ropporin", "protein_names_uniprotkb": "Ropporin-1; Rhophilin-associated 'oppo' protein; Rhophilin-associated protein 1", "protein_names_refseq": "rhophilin-associated 'oppo' protein; rhophilin-associated oppo protein; rhophilin-associated protein 1; ropporin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:76378)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10591629;11278869;20731842;21750661;23303679;27398160", "class_list": "", "function": "CABYR expresses at the late stage of spermiogenesis and its isoforms oligomerize and bind with AKAPs and ropporin. Publication Status: Online-Only, [RefSeq, PubMed]; Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Mutations in ROPN1 and ROPN1L can cause defects in fibrous sheath integrity, sperm motility, and PKA-dependent signaling processes, leading to male infertility. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVG5", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0097598 sperm cytoplasmic droplet;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031514 motile cilium;GO:0097228 sperm principal piece", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0048240 sperm capacitation;GO:0001932 regulation of protein phosphorylation;GO:0061512 protein localization to cilium;GO:0044782 cilium organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ESG2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XJ2-1", "uniprot_id": [ { "id": "RN168_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80XJ2", "type": "external" } ], "mass": 64779.0, "length": 565, "protein_name": "E3 ubiquitin-protein ligase RNF168", "gene_name": "Rnf168", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF168", "refseq_ac": [ { "id": "NP_081631", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081631", "type": "external" } ], "gene_names_uniprotkb": "Rnf168; RNF168", "gene_names_refseq": "3110001H15Rik; Rnf168", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF168; 2.3.2.27; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF168; RING-type E3 ubiquitin transferase RNF168; ring fnger protein 168", "tax_id": 10090, "disease": "RIDDLE syndrome (Disease Ontology:DOID:0090113)", "pathway": " (mmu:70238); (R-MMU-3108214); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-69473)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "20080757;21183079;21552324;21750661;23525009;25428506;33529165;34428180;36944318", "class_list": "", "function": "Degradation of Ubiquitin-Editing Enzyme A20 following Autophagy Activation Promotes RNF168 Nuclear Translocation and NF-kappaB Activation in Lupus Nephritis., [RefSeq, PubMed]; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively)., [UniProtKB, HAMAP, PubMed, UniProtKB]; RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors., [RefSeq, PubMed]; RNF168, in complex with RAD6A or RAD6B, is activated in the DNA-damage-induced protein ubiquitination cascade., [RefSeq, PubMed]; Rnf168 is important for maintaining genomic integrity, and it cooperates with p53 in suppressing tumorigenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "1.14.11.69", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:0004842 ubiquitin-protein transferase activity;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0035861 site of double-strand break", "go_biological_process": "GO:0097680 double-strand break repair via classical nonhomologous end joining;GO:0006974 DNA damage response;GO:0032880 regulation of protein localization;GO:0006302 double-strand break repair;GO:0006303 double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q80XJ2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O89026-1", "uniprot_id": [ { "id": "ROBO1_MOUSE", "url": "https://www.uniprot.org/uniprot/O89026", "type": "external" } ], "mass": 176407.0, "length": 1612, "protein_name": "Roundabout homolog 1", "gene_name": "Robo1", "organism": "Mouse", "refseq_name": "roundabout homolog 1 isoform 2 precursor", "refseq_ac": [ { "id": "NP_062286", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062286", "type": "external" } ], "gene_names_uniprotkb": "Robo1; Dutt1", "gene_names_refseq": "DUTT1; Gm310; Robo1", "protein_names_uniprotkb": "Roundabout homolog 1", "protein_names_refseq": "roundabout homolog 1 isoform 2 precursor; roundabout homolog 1", "tax_id": 10090, "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); combined or isolated pituitary hormone deficiency 8 (Disease Ontology:DOID:0061018); autosomal recessive congenital nystagmus 8 (Disease Ontology:DOID:0061178); polymyositis (Disease Ontology:DOID:0080745); dermatomyositis (Disease Ontology:DOID:10223); pre-eclampsia (Disease Ontology:DOID:10591); lung cancer (Disease Ontology:DOID:1324); transient cerebral ischemia (Disease Ontology:DOID:224); cystic kidney disease (Disease Ontology:DOID:2975); plasmacytoma (Disease Ontology:DOID:3721); lung non-small cell carcinoma (Disease Ontology:DOID:3908); diabetic retinopathy (Disease Ontology:DOID:8947); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:19876); (R-MMU-376176); (R-MMU-428890); (R-MMU-8985586); (R-MMU-9010553)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10433822;11734623;12123796;15091338;19684588;19706539;21750661;24560577;30899004;35227688;9608531", "class_list": "", "function": "Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10433822, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (By similarity). May be required for lung development (PubMed:11734623)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 14, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0030275 LRR domain binding;GO:0008046 axon guidance receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0009986 cell surface", "go_biological_process": "GO:0070100 negative regulation of chemokine-mediated signaling pathway;GO:0007507 heart development;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "O89026-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51448-1", "uniprot_id": [ { "id": "RORA_MOUSE", "url": "https://www.uniprot.org/uniprot/P51448", "type": "external" } ], "mass": 58845.0, "length": 523, "protein_name": "Nuclear receptor ROR-alpha", "gene_name": "Rora", "organism": "Mouse", "refseq_name": "nuclear receptor ROR-alpha isoform 2", "refseq_ac": [ { "id": "NP_001276845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276845", "type": "external" } ], "gene_names_uniprotkb": "Rora; Nr1f1; Rzra", "gene_names_refseq": "9530021D13Rik; Nr1f1; ROR1; ROR2; ROR3; Rora; nmf267; sg; staggerer; tmgc26", "protein_names_uniprotkb": "Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; RAR-related orphan receptor A; Retinoid-related orphan receptor-alpha", "protein_names_refseq": "RAR-related orphan receptor A; nuclear receptor ROR-alpha isoform 2; nuclear receptor ROR-alpha; nuclear receptor RZR-alpha; nuclear receptor subfamily 1 group F member 1; retinoid-related orphan receptor-alpha", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); childhood-onset asthma (Disease Ontology:DOID:0080815); nocturnal asthma (Disease Ontology:DOID:0080826); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); lung non-small cell carcinoma (Disease Ontology:DOID:3908); tuberculosis (Disease Ontology:DOID:399); allergic rhinitis (Disease Ontology:DOID:4481); myocardial infarction (Disease Ontology:DOID:5844); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (mmu:19883); (R-MMU-383280); (R-MMU-4090294)", "pathway_count": 3, "publication_count": 30, "publication_id_list": "11053433;14687547;15821743;17476214;17666523;18055760;18164222;18441015;18535165;19014374;19039140;19324970;19381306;19965867;20159955;20300063;21499262;21628546;21750661;22170608;22753030;22789990;23172836;23723244;33109704;34428180;7935491;8602221;8750880;9226375", "class_list": "", "function": "Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development, regulates SHH gene expression, among others, to induce granule cells proliferation as well as expression of genes involved in calcium-mediated signal transduction. Regulates the circadian expression of several clock genes, including CLOCK, BMAL1, NPAS2 and CRY1. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Regulates genes involved in lipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 and PPARG. In liver, has specific and redundant functions with RORC as positive or negative modulator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as CYP7B1 and SULT2A1. Induces a rhythmic expression of some of these genes. In addition, interplays functionally with NR1H2 and NR1H3 for the regulation of genes involved in cholesterol metabolism. Also involved in the regulation of hepatic glucose metabolism through the modulation of G6PC1 and PCK1. In adipose tissue, plays a role as negative regulator of adipocyte differentiation, probably acting through dual mechanisms. May suppress CEBPB-dependent adipogenesis through direct interaction and PPARG-dependent adipogenesis through competition for DNA-binding. Downstream of IL6 and TGFB and synergistically with RORC isoform 2, is implicated in the lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. Involved in hypoxia signaling by interacting with and activating the transcriptional activity of HIF1A. May inhibit cell growth in response to cellular stress. May exert an anti-inflammatory role by inducing CHUK expression and inhibiting NF-kappa-B signaling., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70283;P97741;P97773;Q923G1", "ec_number_list": [], "go_molecular_function": "GO:0008142 oxysterol binding;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P51448-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70335-1", "uniprot_id": [ { "id": "ROCK1_MOUSE", "url": "https://www.uniprot.org/uniprot/P70335", "type": "external" } ], "mass": 158171.0, "length": 1354, "protein_name": "Rho-associated protein kinase 1", "gene_name": "Rock1", "organism": "Mouse", "refseq_name": "rho-associated protein kinase 1", "refseq_ac": [ { "id": "NP_033097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033097", "type": "external" } ], "gene_names_uniprotkb": "Rock1", "gene_names_refseq": "1110055K06Rik; Rock-I; Rock1", "protein_names_uniprotkb": "Rho-associated protein kinase 1; 2.7.11.39; ROCK-I; Rho-associated, coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase I; p160 ROCK-1; p160ROCK", "protein_names_refseq": "Rho-associated coiled-coil forming kinase 1; p160 ROCK-1; p160ROCK; rho-associated protein kinase 1; rho-associated, coiled-coil-containing protein kinase 1; rho-associated, coiled-coil-containing protein kinase I", "tax_id": 10090, "disease": "", "pathway": " (mmu:19877); (R-MMU-111465); (R-MMU-3928662); (R-MMU-416482); (R-MMU-416572); (R-MMU-4420097); (R-MMU-5627117); (R-MMU-6798695); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013407); (R-MMU-9013422); (R-MMU-9696264)", "pathway_count": 14, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;15753128;16741948;17654484;19036714;19181962;20008297;21183079;21750661;21768292;22493320;22872234;25428506;26740625;30084848;30115939;31219806;34418053;34428180;36210013;38616733;39374570;39627609;8772201", "class_list": "", "function": "Caspase-resistant ROCK1 expression prolongs survival of Emicro-Myc B cell lymphoma mice., [RefSeq, PubMed]; Inhibition of the FOXO1-ROCK1 axis mitigates cardiomyocyte injury under chronic hypoxia in Tetralogy of Fallot by maintaining mitochondrial quality control., [RefSeq, PubMed]; Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:19036714, PubMed:19181962). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:19036714, PubMed:19181962). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By similarity). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (PubMed:20008297). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (PubMed:30115939). Promotes keratinocyte terminal differentiation (By similarity). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (PubMed:21768292). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (PubMed:15753128)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8C3G4;Q8C7H0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.17.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.22", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.3.2", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" } ], "go_molecular_function": "GO:0072518 Rho-dependent protein serine/threonine kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0071559 response to transforming growth factor beta;GO:1905205 positive regulation of connective tissue replacement;GO:0022614 membrane to membrane docking;GO:1903140 regulation of establishment of endothelial barrier;GO:1903347 negative regulation of bicellular tight junction assembly", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P70335-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PDX6-1", "uniprot_id": [ { "id": "RN220_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PDX6", "type": "external" } ], "mass": 62693.0, "length": 566, "protein_name": "E3 ubiquitin-protein ligase Rnf220", "gene_name": "Rnf220", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase Rnf220 isoform 2", "refseq_ac": [ { "id": "NP_001297658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297658", "type": "external" } ], "gene_names_uniprotkb": "Rnf220", "gene_names_refseq": "4732477A13; 4931406I20Rik; 5730503K05Rik; Rnf220", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Rnf220; 2.3.2.27; RING finger protein 220; RING-type E3 ubiquitin transferase Rnf220", "protein_names_refseq": "E3 ubiquitin-protein ligase Rnf220 isoform 2; E3 ubiquitin-protein ligase Rnf220; RING-type E3 ubiquitin transferase Rnf220", "tax_id": 10090, "disease": "hypomyelinating leukodystrophy 23 (Disease Ontology:DOID:0070397)", "pathway": " (mmu:66743); (R-MMU-983168)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "20170641;21183079;21750661;25428506;31219806;31291587;32094113;32814877;33964137;34203471;34428180;36179027;36852467;38324685;40021952;40885482", "class_list": "", "function": "E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of multiple substrates including GRIA1, GRIA2, PHOX2A and PHOX2B, STAT1, STAT3 and SIN3B. Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling. Plays a critical role in the regulation of nuclear lamina. Modulates synaptic activity and brain functions by promoting degradation of AMPA receptor subunits GRIA1 and GRIA2 (PubMed:36179027). The RNF220/ZC4H2 complex monoubiquitinates PHOX2A and PHOX2B to enhance their DNA-binding ability and transactivity (PubMed:32094113). Promotes 'Lys-63'-linked polyubiquitination of Gli transcriptional activators and repressors, facilitating their nuclear export by CRM1 to fine-tune the sonic hedgehog/Gli signaling (By similarity). Regulates type I and type II interferon responses upon viral or bacterial infection by mediating 'Lys-63'-linked polyubiquitination of STAT1 (PubMed:32814877). Also regulates STAT3 phosphorylation, nuclear translocation, and transcriptional activity via ubiquitination (By similarity). Promotes OLIG1 and OLIG2 'Lys-63'-linked polyubiquitination and stabilization, two master regulatory transcription factors involved in oligodendroglial development (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; RNF220-mediated K63-linked polyubiquitination stabilizes Olig proteins during oligodendroglial development and myelination., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2APP0;Q3T9M4;Q3V3D7;Q8JZY5", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0008013 beta-catenin binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0098794 postsynapse", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0016567 protein ubiquitination;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0000209 protein polyubiquitination;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q6PDX6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99020-1", "uniprot_id": [ { "id": "ROAA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99020", "type": "external" } ], "mass": 30831.0, "length": 285, "protein_name": "Heterogeneous nuclear ribonucleoprotein A/B", "gene_name": "Hnrnpab", "organism": "Mouse", "refseq_name": "heterogeneous nuclear ribonucleoprotein A/B isoform 2", "refseq_ac": [ { "id": "NP_034578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034578", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpab; Cbf-a; Cgbfa; Hnrpab", "gene_names_refseq": "3010025C11Rik; CBF-A; Cgbfa; Hnrnpab; Hnrpab", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein A/B; CArG-binding factor-A; CBF-A; hnRNP A/B", "protein_names_refseq": "CArG-binding factor-A; S1 protein D2; heterogeneous nuclear ribonucleoprotein A/B isoform 2; hnRNP A/B", "tax_id": 10090, "disease": "autosomal dominant limb-girdle muscular dystrophy type 3 (Disease Ontology:DOID:0110306); transient cerebral ischemia (Disease Ontology:DOID:224); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:15384)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12086581;1398104;23806337;24129315;30084848;30314980;33725478;34428180;36288343;37083330;37453647;38944160;7522249", "class_list": "", "function": "Axonal mRNA binding of hnRNP A/B is crucial for axon targeting and maturation of olfactory sensory neurons., [RefSeq, PubMed]; HnRNPAB inhibits Influenza A virus infection by disturbing polymerase activity., [RefSeq, PubMed]; Scrutinized the motility of Hnrnpab(-/-) cells and confirmed that the decreases in both cell motility and Eps8 are restored by ectopically coexpressing both alternatively spliced Hnrnpab isoforms, therefore these variants are surprisingly nonredundant for cell motility., [RefSeq, PubMed]; Structure and binding of CBF-A (AUF2), [RefSeq, PubMed]; This gene encodes a protein with consensus RNA binding domains present in a number of other RNA binding proteins and a glycine-rich C-terminus. This gene overlaps in a tail-to-tail orientation the gene encoding alanine-glyoxylate aminotransferase 2-like 2. Some of the exons of this gene are interspersed with exons of alanine-glyoxylate aminotransferase 2-like 2. Two alternatively spliced transcript variants that encode distinct proteins have been described for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptional repressor. Binds to CArG box motifs, single-stranded and double-stranded DNA, and RNA. It may be that repression by CBF-A is a result of competitive binding of CBF, a putative positive factor, and CBF-A to the same or overlapping motifs around the CArG boxes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BPE0", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0044877 protein-containing complex binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030425 dendrite", "go_biological_process": "GO:0060341 regulation of cellular localization;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0016556 mRNA modification;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q99020-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CX86-1", "uniprot_id": [ { "id": "ROA0_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CX86", "type": "external" } ], "mass": 30530.0, "length": 305, "protein_name": "Heterogeneous nuclear ribonucleoprotein A0", "gene_name": "Hnrnpa0", "organism": "Mouse", "refseq_name": "heterogeneous nuclear ribonucleoprotein A0", "refseq_ac": [ { "id": "NP_084148", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084148", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpa0; Hnrpa0", "gene_names_refseq": "1110055B05Rik; 3010025E17Rik; Hnrnpa0; Hnrpa0; hnRNP A0", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein A0; hnRNP A0", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein A0", "tax_id": 10090, "disease": "gastric adenocarcinoma (Disease Ontology:DOID:3717)", "pathway": " (mmu:77134)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "12456657;22645316;23806337;24129315;24532040;25605945;26495903;30084848;31219806;32848054;33300544;34428180;35820727;35822049;36852467;37453647;37507081;39627609", "class_list": "", "function": "Knockdown of Hnrnpa0, a del(5q) gene, alters myeloid cell fate in murine cells through regulation of AU-rich transcripts., [RefSeq, PubMed]; mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0019901 protein kinase binding;GO:0035925 mRNA 3'-UTR AU-rich region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0045202 synapse;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006954 inflammatory response;GO:0032496 response to lipopolysaccharide;GO:0070935 3'-UTR-mediated mRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9CX86-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DB15-1", "uniprot_id": [ { "id": "RM12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DB15", "type": "external" } ], "mass": 21708.0, "length": 201, "protein_name": "Large ribosomal subunit protein bL12m", "gene_name": "Mrpl12", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein bL12m precursor", "refseq_ac": [ { "id": "NP_081480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081480", "type": "external" } ], "gene_names_uniprotkb": "Mrpl12; Rpml12", "gene_names_refseq": "0610034O11Rik; 1500031N16Rik; L12mt; MRP-L12; Mrpl12; Rpml12", "protein_names_uniprotkb": "Large ribosomal subunit protein bL12m; 39S ribosomal protein L12, mitochondrial; L12mt; MRP-L12", "protein_names_refseq": "39S ribosomal protein L12, mitochondrial; large ribosomal subunit protein bL12m precursor; large ribosomal subunit protein bL12m", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 45 (Disease Ontology:DOID:0112113)", "pathway": " (mmu:56282); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9837999); (R-MMU-9937383)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "23576753;23806337;26586915;34428180;40885482", "class_list": "", "function": "As a component of the mitochondrial large ribosomal subunit, plays a role in mitochondrial translation. When present in mitochondria as a free protein not associated with the ribosome, associates with mitochondrial RNA polymerase POLRMT to activate transcription. Required for POLRMT stability., [UniProtKB, UniProtKB]; Knock-down of MRPL12 by RNA interference results in instability of POLRMT., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1ATZ3;Q3TKJ3;Q99JS8", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005761 mitochondrial ribosome", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0006412 translation;GO:0032543 mitochondrial translation;GO:0006390 mitochondrial transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DB15-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50247-1", "uniprot_id": [ { "id": "SAHH_MOUSE", "url": "https://www.uniprot.org/uniprot/P50247", "type": "external" } ], "mass": 47688.0, "length": 432, "protein_name": "Adenosylhomocysteinase", "gene_name": "Ahcy", "organism": "Mouse", "refseq_name": "adenosylhomocysteinase", "refseq_ac": [ { "id": "NP_057870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057870", "type": "external" } ], "gene_names_uniprotkb": "Ahcy", "gene_names_refseq": "Ahcy; CuBP; SAHH", "protein_names_uniprotkb": "Adenosylhomocysteinase; 3.13.2.1; AdoHcyase; CUBP; Liver copper-binding protein; S-adenosyl-L-homocysteine hydrolase", "protein_names_refseq": "S-adenosyl-L-homocysteine hydrolase; adenosylhomocysteinase; adoHcyase; liver copper-binding protein", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase (Disease Ontology:DOID:0111039); abdominal aortic aneurysm (Disease Ontology:DOID:7693); pyridoxine deficiency anemia (Disease Ontology:DOID:8455); hyperhomocysteinemia (Disease Ontology:DOID:9279); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:11615); (mmu:269378); (R-MMU-156581); (R-MMU-1614635)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "21183079;21750661;25605945;31219806;32193337;33300544;34428180;37453647;37507081;37580540;38035769;38064408;39627609;39927985;40684658;7657650", "class_list": "", "function": "Adenosylhomocysteinase plays multiple roles in maintaining the identity and pluripotency of mouse embryonic stem cellsdagger., [RefSeq, PubMed]; Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (PubMed:7657650). Binds copper ions (PubMed:7657650)., [UniProtKB, PubMed]; Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine. Binds copper ions., [UniProtKB, UniProtKB]; Inhibition of AHCY impedes proliferation and differentiation of mouse and human adipocyte progenitor cells., [RefSeq, PubMed]; Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91WF1", "ec_number_list": [ { "id": "3.13.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.13.2.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0005507 copper ion binding;GO:0004013 adenosylhomocysteinase activity;GO:0030554 adenyl nucleotide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0042470 melanosome", "go_biological_process": "GO:0007584 response to nutrient;GO:0006730 one-carbon metabolic process;GO:0002439 chronic inflammatory response to antigenic stimulus;GO:0019510 S-adenosylhomocysteine catabolic process;GO:0042745 circadian sleep/wake cycle", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P50247-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100010000001.010.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E861-1", "uniprot_id": [ { "id": "SCLT1_MOUSE", "url": "https://www.uniprot.org/uniprot/G5E861", "type": "external" } ], "mass": 80492.0, "length": 688, "protein_name": "Sodium channel and clathrin linker 1", "gene_name": "Sclt1", "organism": "Mouse", "refseq_name": "sodium channel and clathrin linker 1", "refseq_ac": [ { "id": "NP_001074880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074880", "type": "external" } ], "gene_names_uniprotkb": "Sclt1; Sap1", "gene_names_refseq": "2610207F23Rik; 4931421F20Rik; CAGGS-SB10; Sclt1; Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla", "protein_names_uniprotkb": "Sodium channel and clathrin linker 1; Sodium channel-associated protein 1", "protein_names_refseq": "sodium channel and clathrin linker 1; sodium channel-associated protein 1", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861)", "pathway": " (mmu:67161); (R-MMU-5620912)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21183079;21750661;29187734;34428180", "class_list": "", "function": "Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PAJ0;Q9CSV4;Q9CUR9", "ec_number_list": [], "go_molecular_function": "GO:0017080 sodium channel regulator activity;GO:0030276 clathrin binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0060271 cilium assembly;GO:0045162 clustering of voltage-gated sodium channels", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "G5E861-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61207-1", "uniprot_id": [ { "id": "SAP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61207", "type": "external" } ], "mass": 61422.0, "length": 557, "protein_name": "Prosaposin", "gene_name": "Psap", "organism": "Mouse", "refseq_name": "prosaposin isoform A precursor", "refseq_ac": [ { "id": "NP_001139592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139592", "type": "external" } ], "gene_names_uniprotkb": "Psap; Sgp1", "gene_names_refseq": "Psap; SGP-1", "protein_names_uniprotkb": "Prosaposin; SGP-1; Sulfated glycoprotein 1", "protein_names_refseq": "prosaposin isoform A precursor; snoRNA MBII-198; sulfated glycoprotein 1", "tax_id": 10090, "disease": "late onset Parkinson's disease (Disease Ontology:DOID:0060892); atypical Gaucher's disease due to saposin c deficiency (Disease Ontology:DOID:0110961); combined saposin deficiency (Disease Ontology:DOID:0111330); metachromatic leukodystrophy (Disease Ontology:DOID:10581); Krabbe disease (Disease Ontology:DOID:10587); Gaucher's disease (Disease Ontology:DOID:1926)", "pathway": " (mmu:19156); (R-MMU-114608); (R-MMU-375276); (R-MMU-418594); (R-MMU-6798695); (R-MMU-9840310)", "pathway_count": 6, "publication_count": 31, "publication_id_list": "10.1101/2023.09.13.557529;12813057;1590788;17322886;19349973;21750661;23690594;25428506;26192747;26370502;26495903;26740625;28011936;30059200;30779550;30899004;31599954;32152506;32201884;34203471;34428180;35822049;37269057;37337846;37436891;37507081;37726325;37828378;40885482;8334382;8565332", "class_list": "", "function": "Acts as a lysosomal activator protein that stimulates acid ceramidase (EC 3.5.1.23) by solubilizing and presenting ceramide substrates at the lipid-water interface, facilitating their hydrolysis into sphingosine and fatty acids. It also activates acid sphingomyelinase (EC 3.1.4.12), though ceramide catabolism represents its primary physiological role., [UniProtKB, PubMed]; Acts as an essential lysosomal cofactor that activates acid beta-glucosylceramidases (EC 3.2.1.45) by altering lipid bilayer properties to facilitate enzyme access to its membrane-embedded glucosylceramide substrate, while also protecting glucocerebrosidase from intralysosomal proteolytic degradation., [UniProtKB, PubMed]; Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling., [UniProtKB, PubMed]; Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling., [RefSeq, PubMed]; Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents. Publication Status: Online-Only, [RefSeq, PubMed]; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling., [UniProtKB, UniProtKB, UniProtKB]; Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate., [UniProtKB, UniProtKB, UniProtKB]; Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases., [UniProtKB, UniProtKB, UniProtKB]; Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12)., [UniProtKB, UniProtKB, UniProtKB]; Saposins are specific low-molecular mass non-enzymatic glycoproteins that act as activator proteins for lysosomal sphingolipid-degrading enzymes, facilitating the hydrolysis of sphingolipids by extracting lipid substrates from membranes and presenting them to their respective enzymes. They are derived from a common precursor protein, prosaposin, which is proteolytically cleaved to yield four homologous proteins (saposin A, B, C, and D), each with distinct but partially overlapping lipid and enzyme specificities., [UniProtKB, UniProtKB]; Saposins are specific low-molecular mass non-enzymatic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases., [UniProtKB, UniProtKB, UniProtKB]; Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases., [UniProtKB, UniProtKB, UniProtKB]; Single-cell RNA-sequencing analysis reveals enhanced non-canonical neurotrophic factor signaling in the subacute phase of traumatic brain injury., [RefSeq, PubMed]; Stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A ARSA (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases., [UniProtKB, UniProtKB]; This gene encodes a multifunctional glycoprotein that plays a role in the intracellular metabolism of various sphingolipids or secreted into the plasma, milk or cerebrospinal fluid. The encoded protein undergoes proteolytic processing to generate four different polypeptides known as saposin A, B, C or D, that are required for the hydrolysis of certain sphingolipids by lysosomal hydrolases. Alternately, the encoded protein is secreted into body fluids where it exhibits neurotrophic and myelinotrophic activities. A complete lack of the encoded protein is fatal to mice either at the neonatal stage or within the first month due to severe leukodystrophy and sphingolipid accumulation. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature saposins. [provided by RefSeq, Sep 2015]., [RefSeq]; acts as an essential lysosomal cofactor that activates galactocerebrosidase (GALC, EC 3.2.1.46) by facilitating enzyme access to its membrane-embedded galactosylceramide substrate, the principal lipid component of myelin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 25, "disease_count": 6, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q60861;Q64006;Q64219", "ec_number_list": [], "go_molecular_function": "GO:1905573 ganglioside GM1 binding;GO:0002020 protease binding;GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "GO:0006664 glycolipid metabolic process;GO:0006886 intracellular protein transport;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0043410 positive regulation of MAPK cascade;GO:0050885 neuromuscular process controlling balance", "synthesized_glycan_count": 0, "hit_score": 6.8, "record_id": "Q61207-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88343-1", "uniprot_id": [ { "id": "S4A4_MOUSE", "url": "https://www.uniprot.org/uniprot/O88343", "type": "external" } ], "mass": 121484.0, "length": 1079, "protein_name": "Electrogenic sodium bicarbonate cotransporter 1", "gene_name": "Slc4a4", "organism": "Mouse", "refseq_name": "electrogenic sodium bicarbonate cotransporter 1 isoform b", "refseq_ac": [ { "id": "NP_001129732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129732", "type": "external" } ], "gene_names_uniprotkb": "Slc4a4; Nbc1; Nbce1", "gene_names_refseq": "NBC1; NBC; Slc4a4", "protein_names_uniprotkb": "Electrogenic sodium bicarbonate cotransporter 1; Na(+)/HCO3(-) cotransporter; Sodium bicarbonate cotransporter; Solute carrier family 4 member 4", "protein_names_refseq": "Na(+)/HCO3(-) cotransporter; electrogenic sodium bicarbonate cotransporter 1 isoform b; electrogenic sodium bicarbonate cotransporter 1; pancreas sodium bicarbonate cotransporter; solute carrier family 4 member 4; solute carrier family 4, sodium bicarbonate cotransporter, member 4", "tax_id": 10090, "disease": "proximal renal tubular acidosis-ocular anomaly syndrome (Disease Ontology:DOID:0061195); hypertension (Disease Ontology:DOID:10763); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); renal tubular acidosis (Disease Ontology:DOID:14219); anemia (Disease Ontology:DOID:2355); cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (mmu:54403); (R-MMU-425381)", "pathway_count": 2, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;11171615;12388213;12604466;12727194;14567693;15218065;16769890;17242355;18034455;18630941;19033647;21183079;21317537;21750661;25428506;27382360;30084848;33300544;34428180;36210013;37828378;38709635;9651366", "class_list": "", "function": "Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a CCL2-CCR2 pathway and NO dysregulation., [RefSeq, PubMed]; Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Existence of an intracellular HCO(3)(-) concentration- and cell volume-independent activation of colonic NBC by an increase in intracellular cAMP., [RefSeq, PubMed]; These results suggest that the pancreatic sodium-bicarbonate cotransporter contributes to pH(i) regulation in the parotid acinar cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3USE4;Q8BUG0;Q8QZR9;Q9R1C4", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008509 monoatomic anion transmembrane transporter activity;GO:0015293 symporter activity;GO:0005452 solute:inorganic anion antiporter activity;GO:0008510 sodium:bicarbonate symporter activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0055085 transmembrane transport;GO:0045821 positive regulation of glycolytic process;GO:0035725 sodium ion transmembrane transport;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "O88343-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q761V0-1", "uniprot_id": [ { "id": "SC6A5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q761V0", "type": "external" } ], "mass": 87861.0, "length": 799, "protein_name": "Sodium- and chloride-dependent glycine transporter 2", "gene_name": "Slc6a5", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc6a5; Glyt2", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium- and chloride-dependent glycine transporter 2; GlyT-2; GlyT2; Solute carrier family 6 member 5", "protein_names_refseq": "", "tax_id": 10090, "disease": "hyperekplexia 3 (Disease Ontology:DOID:0060698); Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (R-MMU-442660)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;15081419;21183079;21750661;22645316;40021952", "class_list": "", "function": "Sodium- and chloride-dependent glycine transporter. Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFM5;Q91ZQ2", "ec_number_list": [], "go_molecular_function": "GO:0015187 glycine transmembrane transporter activity;GO:0046872 metal ion binding;GO:0015375 glycine:sodium symporter activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0042734 presynaptic membrane;GO:0098690 glycinergic synapse;GO:0031045 dense core granule", "go_biological_process": "GO:0015816 glycine transport;GO:0060012 synaptic transmission, glycinergic;GO:0035725 sodium ion transmembrane transport;GO:0001504 neurotransmitter uptake;GO:0098810 neurotransmitter reuptake", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q761V0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQA3-1", "uniprot_id": [ { "id": "SDHB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQA3", "type": "external" } ], "mass": 31814.0, "length": 282, "protein_name": "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial", "gene_name": "Sdhb", "organism": "Mouse", "refseq_name": "succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_075863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075863", "type": "external" } ], "gene_names_uniprotkb": "Sdhb", "gene_names_refseq": "0710008N11Rik; Sdhb", "protein_names_uniprotkb": "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; 1.1.5.-; 1.3.5.1; Ip; Iron-sulfur subunit of complex II; Malate dehydrogenase [quinone] iron-sulfur subunit", "protein_names_refseq": "ip; iron-sulfur subunit of complex II; malate dehydrogenase [quinone] iron-sulfur subunit; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform 1 precursor; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; succinate dehydrogenase complex subunit B", "tax_id": 10090, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); paraganglioma (Disease Ontology:DOID:0050773); mitochondrial complex II deficiency (Disease Ontology:DOID:0060537); pheochromocytoma/paraganglioma syndrome 4 (Disease Ontology:DOID:0061219); Carney-Stratakis syndrome (Disease Ontology:DOID:0080533); mitochondrial encephalomyopathy (Disease Ontology:DOID:890); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (mmu:67680); (R-MMU-71403); (R-MMU-9854311)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "22645316;23576753;34428180;36288343;37453647;37507081;39927985", "class_list": "", "function": "Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TF82;Q9DC91", "ec_number_list": [ { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.3.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.5.1", "type": "external" }, { "id": "1.1.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.5.-", "type": "external" }, { "id": "2.8.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.7", "type": "external" } ], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0051538 3 iron, 4 sulfur cluster binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005886 plasma membrane", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0022904 respiratory electron transport chain;GO:0006105 succinate metabolic process;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CQA3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810B8-1", "uniprot_id": [ { "id": "SLIK4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q810B8", "type": "external" } ], "mass": 94538.0, "length": 837, "protein_name": "SLIT and NTRK-like protein 4", "gene_name": "Slitrk4", "organism": "Mouse", "refseq_name": "SLIT and NTRK-like protein 4 precursor", "refseq_ac": [ { "id": "NP_848855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848855", "type": "external" } ], "gene_names_uniprotkb": "Slitrk4", "gene_names_refseq": "6430513G13; D930039I09Rik; Slitrk4", "protein_names_uniprotkb": "SLIT and NTRK-like protein 4", "protein_names_refseq": "SLIT and NTRK-like protein 4 precursor; SLIT and NTRK-like protein 4; slit and trk like gene 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:245446); (R-MMU-388844)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;14550773;21750661;25989451;33300544;37012514", "class_list": "", "function": "It is involved in synaptogenesis and promotes synapse differentiation (By similarity). Suppresses neurite outgrowth (PubMed:14550773)., [UniProtKB, UniProtKB, PubMed]; The SLITRK4-CNPY3 axis promotes liver metastasis of gastric cancer by enhancing the endocytosis and recycling of TrkB in tumour cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BL56;Q8BWB0;Q8BYG4;Q8C056", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007409 axonogenesis;GO:0007613 memory;GO:0008283 cell population proliferation;GO:0051965 positive regulation of synapse assembly;GO:0001662 behavioral fear response", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q810B8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YWJ0-1", "uniprot_id": [ { "id": "SLIP_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YWJ0", "type": "external" } ], "mass": 91269.0, "length": 796, "protein_name": "Nuclear GTPase SLIP-GC", "gene_name": "Nuggc", "organism": "Mouse", "refseq_name": "nuclear GTPase SLIP-GC isoform X2", "refseq_ac": [ { "id": "XP_006518364", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006518364", "type": "external" } ], "gene_names_uniprotkb": "Nuggc; Gm600", "gene_names_refseq": "Gm600; Nuggc; SLIP-GC", "protein_names_uniprotkb": "Nuclear GTPase SLIP-GC; 3.6.1.-; Speckled-like pattern in the germinal center", "protein_names_refseq": "nuclear GTPase SLIP-GC isoform X2", "tax_id": 10090, "disease": "", "pathway": " (mmu:100503545)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;22833677;31219806", "class_list": "", "function": "Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (By similarity). Reduces somatic hypermutation in B-cells which may enhance genome stability (PubMed:22833677)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0033262 regulation of nuclear cell cycle DNA replication;GO:0043066 negative regulation of apoptotic process;GO:0071222 cellular response to lipopolysaccharide;GO:0006974 DNA damage response;GO:0016446 somatic hypermutation of immunoglobulin genes", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3YWJ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54988-1", "uniprot_id": [ { "id": "SLK_MOUSE", "url": "https://www.uniprot.org/uniprot/O54988", "type": "external" } ], "mass": 141457.0, "length": 1233, "protein_name": "STE20-like serine/threonine-protein kinase", "gene_name": "Slk", "organism": "Mouse", "refseq_name": "STE20-like serine/threonine-protein kinase isoform 2", "refseq_ac": [ { "id": "NP_001158111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158111", "type": "external" } ], "gene_names_uniprotkb": "Slk; Kiaa0204; Stk2", "gene_names_refseq": "9A2; Etk4; SMAK; Slk; Stk2; mKIAA0204; mSLK", "protein_names_uniprotkb": "STE20-like serine/threonine-protein kinase; 2.7.11.1; Etk4; STE20-like kinase; STE20-related kinase SMAK; STE20-related kinase; STE20-related serine/threonine-protein kinase; Serine/threonine-protein kinase 2; mSLK", "protein_names_refseq": "STE20-like serine/threonine-protein kinase isoform 2; STE20-like serine/threonine-protein kinase; STE20-related kinase SMAK; STE20-related serine/threonine-protein kinase; serine/threonine-protein kinase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:20874); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106)", "pathway_count": 4, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10611247;17242355;17525332;21183079;21750661;22645316;25153642;26740625;28135057;31219806;32782141;34428180;36288343;36579845;37828378;38163671;38871226;8346215;9808774", "class_list": "", "function": "Expression of a kinase inactive SLK is embryonic lethal and impairs cell migration in fibroblasts., [RefSeq, PubMed]; Mediates apoptosis and actin stress fiber dissolution., [UniProtKB, PubMed]; Role of the Ste20-like kinase SLK in podocyte adhesion., [RefSeq, PubMed]; Ste20-like kinase activity promotes meiotic resumption and spindle microtubule stability in mouse oocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 21, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2RRK4;Q80U65;Q8CAU2;Q8CDW2;Q9WU41", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031252 cell leading edge;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "O54988-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O89032-1", "uniprot_id": [ { "id": "SPD2A_MOUSE", "url": "https://www.uniprot.org/uniprot/O89032", "type": "external" } ], "mass": 124201.0, "length": 1124, "protein_name": "SH3 and PX domain-containing protein 2A", "gene_name": "Sh3pxd2a", "organism": "Mouse", "refseq_name": "SH3 and PX domain-containing protein 2A isoform 2", "refseq_ac": [ { "id": "NP_001158189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158189", "type": "external" } ], "gene_names_uniprotkb": "Sh3pxd2a; Fish; Sh3md1; Tks5", "gene_names_refseq": "2310014D11Rik; C230050L11; EG329070; Fish; Gm5098; Sh3md1; Sh3pxd2a; TSK5; Tks5", "protein_names_uniprotkb": "SH3 and PX domain-containing protein 2A; Five SH3 domain-containing protein; SH3 multiple domains protein 1; Tyrosine kinase substrate with five SH3 domains", "protein_names_refseq": "SH3 and PX domain-containing protein 2A isoform 2; SH3 and PX domain-containing protein 2A; SH3 multiple domains 1; SH3 multiple domains protein 1; five SH3 domain-containing protein; tyrosine kinase substrate with five SH3 domains", "tax_id": 10090, "disease": "", "pathway": " (mmu:14218); (R-MMU-8941237)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;17242355;18417249;18982058;19464300;19755709;21183079;21750661;25153642;25428506;28528544;30059200;34428180;34769479;35984892;37735172;9687503", "class_list": "", "function": "Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Data suggest that Src-dependent phosphorylation of beta-dystroglycan results in the formation of a Src/dystroglycan complex that drives the SH3-mediated association between dystroglycan and Tks5 which together regulate podosome formation in myoblasts., [RefSeq, PubMed]; SRC and TKS5 mediated podosome formation in fibroblasts promotes extracellular matrix invasion and pulmonary fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; The tandem SH3A and SH3B domains of Tks5 constitute a versatile module for the implementation of isoform-specific protein-protein interactions., [RefSeq, PubMed]; Tks5 Regulates Synaptic Podosome Formation and Stabilization of the Postsynaptic Machinery at the Neuromuscular Junction. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QKJ2;Q148Q8", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0002020 protease binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0002102 podosome;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0072593 reactive oxygen species metabolic process;GO:0072675 osteoclast fusion;GO:0006801 superoxide metabolic process;GO:0042554 superoxide anion generation", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "O89032-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97471-1", "uniprot_id": [ { "id": "SMAD4_MOUSE", "url": "https://www.uniprot.org/uniprot/P97471", "type": "external" } ], "mass": 60342.0, "length": 551, "protein_name": "SMAD family member 4", "gene_name": "Smad4", "organism": "Mouse", "refseq_name": "SMAD family member 4 isoform 1", "refseq_ac": [ { "id": "NP_032566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032566", "type": "external" } ], "gene_names_uniprotkb": "Smad4; Dpc4; Madh4", "gene_names_refseq": "D18Wsu70e; DPC4; Madh4; Smad4", "protein_names_uniprotkb": "SMAD family member 4; Deletion target in pancreatic carcinoma 4 homolog; MAD homolog 4; Mothers against DPP homolog 4; Mothers against decapentaplegic homolog 4; SMAD 4", "protein_names_refseq": "MAD homolog 4; SMAD family member 4 isoform 1; deletion target in pancreatic carcinoma 4 homolog; mothers against DPP homolog 4; mothers against decapentaplegic homolog 4", "tax_id": 10090, "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787); colorectal adenoma (Disease Ontology:DOID:0050860); pre-malignant neoplasm (Disease Ontology:DOID:0060071); colorectal carcinoma (Disease Ontology:DOID:0080199); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome (Disease Ontology:DOID:0111543); intestinal cancer (Disease Ontology:DOID:10155); urinary bladder cancer (Disease Ontology:DOID:11054); osteogenesis imperfecta (Disease Ontology:DOID:12347); hereditary hemorrhagic telangiectasia (Disease Ontology:DOID:1270); prostatitis (Disease Ontology:DOID:14654); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gastrointestinal system cancer (Disease Ontology:DOID:3119); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); pulmonary fibrosis (Disease Ontology:DOID:3770); Lynch syndrome (Disease Ontology:DOID:3883); cervical cancer (Disease Ontology:DOID:4362); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); aortic disease (Disease Ontology:DOID:520); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic myeloid leukemia (Disease Ontology:DOID:8552); prostate carcinoma in situ (Disease Ontology:DOID:8634); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:17128); (R-MMU-1181150); (R-MMU-1502540); (R-MMU-201451); (R-MMU-2173789); (R-MMU-2173795); (R-MMU-2173796); (R-MMU-5689880); (R-MMU-8941326); (R-MMU-8941855); (R-MMU-9617828)", "pathway_count": 11, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;12370310;15329343;16115198;20147459;21145499;24076600;28528544;31219806;34428180;36210013;9166592", "class_list": "", "function": "Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (PubMed:15329343). In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 32, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6GTP6;Q9CW56", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0003360 brainstem development;GO:0036302 atrioventricular canal development;GO:0071559 response to transforming growth factor beta;GO:0010631 epithelial cell migration;GO:0048729 tissue morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P97471-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60898-1", "uniprot_id": [ { "id": "SLAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60898", "type": "external" } ], "mass": 31681.0, "length": 281, "protein_name": "Src-like-adapter", "gene_name": "Sla", "organism": "Mouse", "refseq_name": "src-like-adapter isoform a", "refseq_ac": [ { "id": "NP_001025012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025012", "type": "external" } ], "gene_names_uniprotkb": "Sla; Slap1; Slap", "gene_names_refseq": "Slap-1; Slap; Sla", "protein_names_uniprotkb": "Src-like-adapter; SLAP-1; Src-like-adapter protein 1; mSLAP", "protein_names_refseq": "src-like-adapter isoform a; src-like-adapter protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:20491); (R-MMU-9706369)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10630289;10662792;10779329;11471062;11567635;17947660;21750661;31156621;34428180;7543898;9742401", "class_list": "", "function": "Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; SLAP Is a Negative Regulator of FcepsilonRI Receptor-Mediated Signaling and Allergic Response. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C9Q8;Q8CAT0;Q8CBE9;Q8QZX8", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0005154 epidermal growth factor receptor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0007165 signal transduction;GO:0043408 regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q60898-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810C1-1", "uniprot_id": [ { "id": "SLIK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q810C1", "type": "external" } ], "mass": 77817.0, "length": 696, "protein_name": "SLIT and NTRK-like protein 1", "gene_name": "Slitrk1", "organism": "Mouse", "refseq_name": "SLIT and NTRK-like protein 1 precursor", "refseq_ac": [ { "id": "NP_951020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_951020", "type": "external" } ], "gene_names_uniprotkb": "Slitrk1; Sltk1", "gene_names_refseq": "3200001I04Rik; Slitrk1", "protein_names_uniprotkb": "SLIT and NTRK-like protein 1", "protein_names_refseq": "SLIT and NTRK-like protein 1 precursor; SLIT and NTRK-like protein 1; slit and trk like gene 1", "tax_id": 10090, "disease": "trichotillomania (Disease Ontology:DOID:0050587); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119)", "pathway": " (mmu:76965); (R-MMU-388844)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;14550773;18794888;27273464", "class_list": "", "function": "It is involved in synaptogenesis and promotes excitatory synapse differentiation (By similarity). Enhances neuronal dendrite outgrowth (PubMed:14550773)., [UniProtKB, UniProtKB, PubMed]; These results lead us to conclude that noradrenergic mechanisms are involved in the behavioral abnormalities of Slitrk1-deficient mice. Elevated anxiety due to Slitrk1 dysfunction may contribute to the pathogenesis of neuropsychiatric diseases, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9474, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q9CXL0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005576 extracellular region;GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:0006897 endocytosis;GO:0007399 nervous system development;GO:0007409 axonogenesis;GO:0030534 adult behavior;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q810C1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C080-1", "uniprot_id": [ { "id": "SNX16_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C080", "type": "external" } ], "mass": 38817.0, "length": 344, "protein_name": "Sorting nexin-16", "gene_name": "Snx16", "organism": "Mouse", "refseq_name": "sorting nexin-16 isoform a", "refseq_ac": [ { "id": "NP_083344", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083344", "type": "external" } ], "gene_names_uniprotkb": "Snx16", "gene_names_refseq": "4930522N22Rik; Snx16", "protein_names_uniprotkb": "Sorting nexin-16", "protein_names_refseq": "sorting nexin-16 isoform a", "tax_id": 10090, "disease": "polycythemia due to hypoxia (Disease Ontology:DOID:2835)", "pathway": " (mmu:74718)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19144319;21183079", "class_list": "", "function": "May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D525", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005764 lysosome;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane;GO:0005770 late endosome", "go_biological_process": "GO:0008333 endosome to lysosome transport;GO:0045022 early endosome to late endosome transport;GO:0006622 protein targeting to lysosome;GO:0001881 receptor recycling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C080-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CU62-1", "uniprot_id": [ { "id": "SMC1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CU62", "type": "external" } ], "mass": 143235.0, "length": 1233, "protein_name": "Structural maintenance of chromosomes protein 1A", "gene_name": "Smc1a", "organism": "Mouse", "refseq_name": "structural maintenance of chromosomes protein 1A", "refseq_ac": [ { "id": "NP_062684", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062684", "type": "external" } ], "gene_names_uniprotkb": "Smc1a; Sb1.8; Smc1l1; Smc1; Smcb", "gene_names_refseq": "5830426I24Rik; SMC-1A; Sb1.8; Smc1alpha; Smc1a; Smc1l1; Smc1; Smcb; mKIAA0178", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein 1A; Chromosome segregation protein SmcB; SMC protein 1A; SMC-1-alpha; SMC-1A; Sb1.8", "protein_names_refseq": "SMC (segregation of mitotic chromosomes 1)-like 1; SMC protein 1A; SMC-1-alpha; chromosome segregation protein SmcB; segregation of mitotic chromosomes b; structural maintenance of chromosomes protein 1A", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 85 (Disease Ontology:DOID:0070380); Cornelia de Lange syndrome 2 (Disease Ontology:DOID:0080506); Cornelia de Lange syndrome (Disease Ontology:DOID:11725); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:24061); (R-MMU-2467813); (R-MMU-2468052); (R-MMU-2470946); (R-MMU-2500257); (R-MMU-3108214)", "pathway_count": 6, "publication_count": 17, "publication_id_list": "10375619;11483963;12498344;21750661;22872234;22977523;23806337;28528544;31219806;33524014;34203471;34428180;34887587;36210013;37096492;37507081;39627609", "class_list": "", "function": "Effects of SMC1A on immune microenvironment and cancer stem cells in colon adenocarcinoma., [RefSeq, PubMed]; Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, and works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint (By similarity). Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint., [UniProtKB]; SMC1alpha is mainly associated with homologous or non-homologous synapsed regions. The protein also localizes along meiotic chromosome cores of Spo11 null spermatocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AFQ5;Q3V480;Q9CUX9;Q9D959;Q9WTU1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0046982 protein heterodimerization activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0030892 mitotic cohesin complex;GO:0030893 meiotic cohesin complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006281 DNA repair;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0019827 stem cell population maintenance;GO:0009314 response to radiation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9CU62-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV80-1", "uniprot_id": [ { "id": "SNX1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WV80", "type": "external" } ], "mass": 58952.0, "length": 522, "protein_name": "Sorting nexin-1", "gene_name": "Snx1", "organism": "Mouse", "refseq_name": "sorting nexin-1", "refseq_ac": [ { "id": "NP_062701", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062701", "type": "external" } ], "gene_names_uniprotkb": "Snx1", "gene_names_refseq": "Snx1", "protein_names_uniprotkb": "Sorting nexin-1", "protein_names_refseq": "sorting nexin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:56440)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11726276;12388759;17242355;21183079;21750661;31599954;33658379;34428180", "class_list": "", "function": "Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1). Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN. Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (By similarity)., [UniProtKB, UniProtKB]; Show that mice lacking sorting nexin 1 or sorting nexin 2 are viable and fertile, whereas embryos deficient in both proteins arrest at midgestation., [RefSeq, PubMed]; Structural insights into membrane remodeling by SNX1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQZ9", "ec_number_list": [], "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0005154 epidermal growth factor receptor binding", "go_cellular_component": "GO:0098999 extrinsic component of postsynaptic endosome membrane;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0031175 neuron projection development;GO:0031623 receptor internalization;GO:0072673 lamellipodium morphogenesis;GO:0045732 positive regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9WV80-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46096-1", "uniprot_id": [ { "id": "SYT1_MOUSE", "url": "https://www.uniprot.org/uniprot/P46096", "type": "external" } ], "mass": 47418.0, "length": 421, "protein_name": "Synaptotagmin-1", "gene_name": "Syt1", "organism": "Mouse", "refseq_name": "synaptotagmin-1 isoform 1", "refseq_ac": [ { "id": "NP_001239270", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239270", "type": "external" } ], "gene_names_uniprotkb": "Syt1", "gene_names_refseq": "G630098F17Rik; Syt1; SytI", "protein_names_uniprotkb": "Synaptotagmin-1; Synaptotagmin I; SytI; p65", "protein_names_refseq": "p65; synaptotagmin-1 isoform 1; synaptotagmin-1", "tax_id": 10090, "disease": "congenital myasthenic syndrome 7 (Disease Ontology:DOID:0110659); congenital myasthenic syndrome (Disease Ontology:DOID:3635); neuromuscular junction disease (Disease Ontology:DOID:439)", "pathway": " (mmu:20979); (R-MMU-181429); (R-MMU-181430); (R-MMU-210500); (R-MMU-212676); (R-MMU-264642); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-888590)", "pathway_count": 9, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11242035;12048209;15466855;17190793;18034455;21183079;21496647;23345244;27052163;30899004;33300544;35820727;7961887", "class_list": "", "function": "Calcium sensor that participates in triggering neurotransmitter release at the synapse (PubMed:11242035). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (PubMed:7961887). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 0, "mined_o_glycosites": 2, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005543 phospholipid binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0030100 regulation of endocytosis;GO:0030154 cell differentiation;GO:0051291 protein heterooligomerization;GO:0051592 response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P46096-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100010000001.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26369-1", "uniprot_id": [ { "id": "U2AF2_MOUSE", "url": "https://www.uniprot.org/uniprot/P26369", "type": "external" } ], "mass": 53517.0, "length": 475, "protein_name": "Splicing factor U2AF 65 kDa subunit", "gene_name": "U2af2", "organism": "Mouse", "refseq_name": "splicing factor U2AF 65 kDa subunit isoform 1", "refseq_ac": [ { "id": "NP_001192160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192160", "type": "external" } ], "gene_names_uniprotkb": "U2af2; U2af65", "gene_names_refseq": "65kDa; U2af2", "protein_names_uniprotkb": "Splicing factor U2AF 65 kDa subunit; U2 auxiliary factor 65 kDa subunit; U2 snRNP auxiliary factor large subunit", "protein_names_refseq": "U2 auxiliary factor 65 kDa subunit; U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), 65 kDa; U2 snRNP auxiliary factor large subunit; splicing factor U2AF 65 kDa subunit isoform 1; splicing factor U2AF 65 kDa subunit", "tax_id": 10090, "disease": "developmental delay, dysmorphic facies, and brain anomalies (Disease Ontology:DOID:0060933)", "pathway": " (mmu:22185); (R-MMU-159236); (R-MMU-72163); (R-MMU-72187); (R-MMU-9629569); (R-MMU-9770562)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "1594454;16819553;21183079;21750661;23806337;29187734;31219806;33725478;34428180;34887587;37453647;37828378;39495216", "class_list": "", "function": "Nuclear translocation of SIRT4 mediates deacetylation of U2AF2 to modulate renal fibrosis through alternative splicing-mediated upregulation of CCN2. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in pre-mRNA splicing and 3'-end processing. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0030628 pre-mRNA 3'-splice site binding;GO:0008187 poly-pyrimidine tract binding;GO:0070742 C2H2 zinc finger domain binding;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0000243 commitment complex", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0008380 RNA splicing;GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0031397 negative regulation of protein ubiquitination;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P26369-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDU5-1", "uniprot_id": [ { "id": "SNRK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDU5", "type": "external" } ], "mass": 81913.0, "length": 748, "protein_name": "SNF-related serine/threonine-protein kinase", "gene_name": "Snrk", "organism": "Mouse", "refseq_name": "SNF-related serine/threonine-protein kinase", "refseq_ac": [ { "id": "NP_001158044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158044", "type": "external" } ], "gene_names_uniprotkb": "Snrk", "gene_names_refseq": "2010012F07Rik; E030034B15; Snrk; mKIAA0096", "protein_names_uniprotkb": "SNF-related serine/threonine-protein kinase; 2.7.11.1; SNF1-related kinase", "protein_names_refseq": "SNF-related serine/threonine-protein kinase; SNF1-related kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:20623)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12234663;21183079;21750661;22645316;24129315;31420304;31718444;34428180;37721051", "class_list": "", "function": "Cardiomyocyte-Specific Snrk Prevents Inflammation in the Heart., [RefSeq, PubMed]; DNA Damage and Nuclear Morphological Changes in Cardiac Hypertrophy Are Mediated by SNRK Through Actin Depolymerization., [RefSeq, PubMed]; May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The SNRK regulates insulin signaling through controlling PPP2R5D phosphorylation, which subsequently impacts PP2A activity and then AKT phosphorylation in both WAT and BAT. SNRK may represent a promising potential target for treating insulin resistance-related metabolic disorders., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91WX6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity;GO:0004672 protein kinase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8VDU5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JK48-1", "uniprot_id": [ { "id": "SHLB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JK48", "type": "external" } ], "mass": 40855.0, "length": 365, "protein_name": "Endophilin-B1", "gene_name": "Sh3glb1", "organism": "Mouse", "refseq_name": "endophilin-B1 isoform 1", "refseq_ac": [ { "id": "NP_001268966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268966", "type": "external" } ], "gene_names_uniprotkb": "Sh3glb1; Kiaa0491", "gene_names_refseq": "Bif-1; Sh3glb1; mKIAA0491", "protein_names_uniprotkb": "Endophilin-B1; SH3 domain-containing GRB2-like protein B1", "protein_names_refseq": "SH3 domain-containing GRB2-like protein B1; endophilin-B1 isoform 1; endophilin-B1", "tax_id": 10090, "disease": "", "pathway": " (mmu:54673)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12456676;16227588;17086176;17381077;21750661;24523556;25428506;26857140;27715385;31243813;34428180", "class_list": "", "function": "Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis., [RefSeq, PubMed]; Characterization of and function at intracellular membranes [endophilin B1b], [RefSeq, PubMed]; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells (PubMed:17086176). May recruit other proteins to membranes with high curvature. May promote membrane fusion (By similarity). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (PubMed:24523556). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (PubMed:24523556)., [UniProtKB, PubMed, UniProtKB, PubMed]; SH3GLB1 controls nicotinic acetylcholine receptors endocytic trafficking in a phosphorylation- and RAB5-dependent manner at steps upstream of autophagosome formation., [RefSeq, PubMed]; These findings thus identify Bif-1 as a novel regulator of lipid homeostasis to prevent the pathogenesis of obesity and its associated metabolic complications. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TYR7;Q6A059;Q8CDS9;Q8VI52;Q9CT31", "ec_number_list": [], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005737 cytoplasm;GO:0005740 mitochondrial envelope;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:2000641 regulation of early endosome to late endosome transport;GO:1903861 positive regulation of dendrite extension;GO:0006654 phosphatidic acid biosynthetic process;GO:0006897 endocytosis;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9JK48-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80YF9-1", "uniprot_id": [ { "id": "RHG33_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80YF9", "type": "external" } ], "mass": 139801.0, "length": 1305, "protein_name": "Rho GTPase-activating protein 33", "gene_name": "Arhgap33", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 33 isoform b", "refseq_ac": [ { "id": "NP_001276599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276599", "type": "external" } ], "gene_names_uniprotkb": "Arhgap33; Snx26; Tcgap", "gene_names_refseq": "Arhgap33; NOMA-GAP; Snx26; TCGAP", "protein_names_uniprotkb": "Rho GTPase-activating protein 33; Rho-type GTPase-activating protein 33; Sorting nexin-26; Tc10/CDC42 GTPase-activating protein", "protein_names_refseq": "TC10/CDC42 GTPase-activating protein; rho GTPase-activating protein 33 isoform b; rho-type GTPase-activating protein 33; sorting nexin 26", "tax_id": 10090, "disease": "", "pathway": " (mmu:233071); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013406)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12773384;16452087;18034455;21183079;21750661;22810622;24003235;24129315;37634443", "class_list": "", "function": "Cofilin activation during late cortical development depended on NOMA-GAP expression and subsequent inhibition of Cdc42. In utero expression of active cofilin was sufficient to restore postnatal dendritic complexity in NOMA-GAP-deficient animals., [RefSeq, PubMed]; May be involved in several stages of intracellular trafficking (By similarity). Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport., [UniProtKB]; May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport., [UniProtKB, UniProtKB]; Overexpression of the full-length and C-terminal fragments of TCGAP inhibits insulin-stimulated glucose uptake and GLUT4 translocation., [RefSeq, PubMed]; Reduced mastication during growth inhibits cognitive function by affecting trigeminal ganglia and modulating Wnt signaling pathway and ARHGAP33 molecular transmission., [RefSeq, PubMed]; Results indicate that SNX26 interacts with PSD-95 and regulates formation of dendritic spines., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9507, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q6P7W6", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0019901 protein kinase binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043197 dendritic spine", "go_biological_process": "GO:0015031 protein transport;GO:0007264 small GTPase-mediated signal transduction;GO:0061001 regulation of dendritic spine morphogenesis;GO:0150052 regulation of postsynapse assembly;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q80YF9-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35226-1", "uniprot_id": [ { "id": "PSMD4_MOUSE", "url": "https://www.uniprot.org/uniprot/O35226", "type": "external" } ], "mass": 40704.0, "length": 376, "protein_name": "26S proteasome non-ATPase regulatory subunit 4", "gene_name": "Psmd4", "organism": "Mouse", "refseq_name": "26S proteasome non-ATPase regulatory subunit 4 isoform 1", "refseq_ac": [ { "id": "NP_001268946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268946", "type": "external" } ], "gene_names_uniprotkb": "Psmd4; Mcb1", "gene_names_refseq": "Af1; Mcb1; Psmd4; angiocidin", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 4; 26S proteasome regulatory subunit RPN10; 26S proteasome regulatory subunit S5A; Multiubiquitin chain-binding protein", "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 4 isoform 1; 26S proteasome non-ATPase regulatory subunit 4; 26S proteasome regulatory subunit RPN10; 26S proteasome regulatory subunit S5A; RPN10 homolog; anti secretory factor 1; multiubiquitin chain-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:19185); (R-MMU-9907900)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10921894;15345747;16857966;17242355;21183079;21750661;22645316;22872234;25428506;34428180;35820727;37453647;37507081;37828378;9511739", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91V59;Q9JJM0;Q9JJM1;Q9JJM2;Q9JJM3", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0022624 proteasome accessory complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O35226-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BP86-1", "uniprot_id": [ { "id": "SNPC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BP86", "type": "external" } ], "mass": 147413.0, "length": 1333, "protein_name": "snRNA-activating protein complex subunit 4", "gene_name": "Snapc4", "organism": "Mouse", "refseq_name": "snRNA-activating protein complex subunit 4 isoform b", "refseq_ac": [ { "id": "NP_001277348", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277348", "type": "external" } ], "gene_names_uniprotkb": "Snapc4", "gene_names_refseq": "5730436L13Rik; Snapc4", "protein_names_uniprotkb": "snRNA-activating protein complex subunit 4; SNAPc 190 kDa subunit; SNAPc subunit 4; snRNA-activating protein complex 190 kDa subunit", "protein_names_refseq": "SNAPc subunit 4; snRNA-activating protein complex 190 kDa subunit; snRNA-activating protein complex subunit 4 isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:227644); (R-MMU-6807505); (R-MMU-76071)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PGG7;Q80UG9;Q810L1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0016251 RNA polymerase II general transcription initiation factor activity;GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding;GO:0000995 RNA polymerase III general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0019185 snRNA-activating protein complex", "go_biological_process": "GO:0042795 snRNA transcription by RNA polymerase II;GO:0042796 snRNA transcription by RNA polymerase III;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BP86-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U6K5-1", "uniprot_id": [ { "id": "SPAT6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U6K5", "type": "external" } ], "mass": 56101.0, "length": 488, "protein_name": "Spermatogenesis-associated protein 6", "gene_name": "Spata6", "organism": "Mouse", "refseq_name": "spermatogenesis-associated protein 6 isoform 1 precursor", "refseq_ac": [ { "id": "NP_080746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080746", "type": "external" } ], "gene_names_uniprotkb": "Spata6; Hash", "gene_names_refseq": "1700062C23Rik; Hash; KRP; Mash; Spata6", "protein_names_uniprotkb": "Spermatogenesis-associated protein 6; Kinesin-related protein", "protein_names_refseq": "kinesin-related protein; spermatogenesis-associated protein 6 isoform 1 precursor; spermatogenesis-associated protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:67946)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12771232;21183079;21750661;25605924;25605945;34428180", "class_list": "", "function": "Inactivation of Spata6 in mice leads to acephalic spermatozoa and male sterility. Our proteomic analyses reveal that SPATA6 is involved in myosin-based microfilament transport through interaction with myosin subunits, [RefSeq, PubMed]; Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis (PubMed:12771232, PubMed:25605924). May be involved in myosin-based microfilament transport through interaction with myosin subunits (PubMed:25605924)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AED7;Q3V104;Q8BW97;Q99MU6;Q9D9J1;Q9DAI3", "ec_number_list": [], "go_molecular_function": "GO:0032027 myosin light chain binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031514 motile cilium;GO:0120212 sperm head-tail coupling apparatus", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0044458 motile cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3U6K5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGF1-1", "uniprot_id": [ { "id": "RHG29_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CGF1", "type": "external" } ], "mass": 142341.0, "length": 1266, "protein_name": "Rho GTPase-activating protein 29", "gene_name": "Arhgap29", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 29", "refseq_ac": [ { "id": "NP_766113", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766113", "type": "external" } ], "gene_names_uniprotkb": "Arhgap29", "gene_names_refseq": "6720461J18Rik; A830014I19; Arhgap29; B130017I01Rik; Parg1", "protein_names_uniprotkb": "Rho GTPase-activating protein 29; Rho-type GTPase-activating protein 29", "protein_names_refseq": "PTPL1-associated RhoGAP 1; rho GTPase-activating protein 29; rho-type GTPase-activating protein 29", "tax_id": 10090, "disease": "EEC syndrome (Disease Ontology:DOID:0060782)", "pathway": " (mmu:214137); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "15752761;17242355;21183079;21396893;21750661;25428506;30084848;31219806;34428180", "class_list": "", "function": "GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho (By similarity). In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis., [UniProtKB, PubMed]; These results suggest that PARG1 is a putative specific effector of Rap2 to regulate Rho., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V135;Q7TMW2;Q8BLJ2;Q8BLR8", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007165 signal transduction;GO:0051058 negative regulation of small GTPase mediated signal transduction;GO:0051056 regulation of small GTPase mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8CGF1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BG05-1", "uniprot_id": [ { "id": "ROA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BG05", "type": "external" } ], "mass": 39652.0, "length": 379, "protein_name": "Heterogeneous nuclear ribonucleoprotein A3", "gene_name": "Hnrnpa3", "organism": "Mouse", "refseq_name": "heterogeneous nuclear ribonucleoprotein A3 isoform c", "refseq_ac": [ { "id": "NP_444493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444493", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpa3; Hnrpa3", "gene_names_refseq": "2410013L13Rik; 2610209F03Rik; 2610510D13Rik; Hnrnpa3; Hnrpa3", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein A3; hnRNP A3", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein A3 isoform c; hnRNP A3", "tax_id": 10090, "disease": "inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); silicosis (Disease Ontology:DOID:10325); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:229279); (R-MMU-72163); (R-MMU-72203); (R-MMU-9770562)", "pathway_count": 4, "publication_count": 20, "publication_id_list": "16479539;20485683;20885981;21750661;22645316;23386199;24129315;25153642;25605945;28135057;28528544;31219806;32321712;34428180;35820727;35984892;37453647;37507081;39627609;8133041", "class_list": "", "function": "Heterogeneous nuclear ribonucleoprotein A3 controls mitotic progression of neural progenitors via interaction with cohesin. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHF8", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0051033 RNA transmembrane transporter activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0014069 postsynaptic density;GO:0098794 postsynapse", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0051028 mRNA transport;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q8BG05-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97325-1", "uniprot_id": [ { "id": "SIAT6_MOUSE", "url": "https://www.uniprot.org/uniprot/P97325", "type": "external" } ], "mass": 42132.0, "length": 374, "protein_name": "CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase", "gene_name": "St3gal3", "organism": "Mouse", "refseq_name": "CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform a", "refseq_ac": [ { "id": "NP_001155246", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155246", "type": "external" } ], "gene_names_uniprotkb": "St3gal3; Siat3; Siat6", "gene_names_refseq": "ST3GalIII; ST3N; Siat3; Siat6; St3gal3", "protein_names_uniprotkb": "CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase; 2.4.3.6; Alpha 2,3-ST 3; Beta-galactoside alpha-2,3-sialyltransferase 3; Gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase; N-acetyllactosaminide alpha-2,3-sialyltransferase; ST3Gal III; ST3GalIII; ST3N; Sialyltransferase 6", "protein_names_refseq": "CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform a; CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase; N-acetyllactosaminide alpha-2,3-sialyltransferase; beta-galactoside alpha-2,3-sialyltransferase 3; gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase; sialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sialyltransferase)", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 15 (Disease Ontology:DOID:0080414); autosomal recessive intellectual developmental disorder 12 (Disease Ontology:DOID:0081180)", "pathway": " (mmu:20441); (R-MMU-2022854); (R-MMU-4085001); (R-MMU-9037629); (R-MMU-977068); (R-MMU-9840309)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12393657;21750661;23830412;25846372;31219806;38139047;9184827", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc., [UniProtKB, PubMed]; Knock-out mice have enhanced allergic eosinophilic airway inflammation, [RefSeq, PubMed]; Sialyltransferase Mutations Alter the Expression of Calcium-Binding Interneurons in Mice Neocortex, Hippocampus and Striatum. Publication Status: Online-Only, [RefSeq, PubMed]; St3gal2/3 double-null mice displayed dysmyelination marked by a reduction in major myelin proteins, fewer myelinated axons, a decrease in myelin thickness, possibly by dysregulation of ganglioside-mediated oligodendroglial precursor cell proliferation., [RefSeq, PubMed]; Was not found to play a role in regulating synthesis of selectin ligands nor in vitro rolling of marrow-derived neutrophils on E- or P-selectins presented by Chinese hamster ovary cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q922X5", "ec_number_list": [ { "id": "2.4.3.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.9", "type": "external" }, { "id": "2.4.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.2", "type": "external" }, { "id": "2.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.4", "type": "external" }, { "id": "2.4.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.6", "type": "external" } ], "go_molecular_function": "GO:0008373 sialyltransferase activity;GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity;GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane;GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0001574 ganglioside biosynthetic process", "synthesized_glycan_count": 2417, "hit_score": 1.3, "record_id": "P97325-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000000.100.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BPQ7-1", "uniprot_id": [ { "id": "SGSM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BPQ7", "type": "external" } ], "mass": 123196.0, "length": 1093, "protein_name": "Small G protein signaling modulator 1", "gene_name": "Sgsm1", "organism": "Mouse", "refseq_name": "small G protein signaling modulator 1 isoform b", "refseq_ac": [ { "id": "NP_001156437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156437", "type": "external" } ], "gene_names_uniprotkb": "Sgsm1; Rutbc2", "gene_names_refseq": "2410098H20Rik; D5Bwg1524e; E130107M15; NuIP; Rutbc2; Sgsm1", "protein_names_uniprotkb": "Small G protein signaling modulator 1; RUN and TBC1 domain-containing protein 2", "protein_names_refseq": "RUN and TBC1 domain containing 2; RUN and TBC1 domain-containing protein 2; nurr1-interacting protein; small G protein signaling modulator 1 isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:52850)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;17509819;19765553;21750661;25220469;30084848;34428180", "class_list": "", "function": "Crystal structure of the Rab9A-RUTBC2 Rab-binding domain complex reveals that RUTBC2 Rab-binding doamin adopts a PH domain fold and mainly uses beta1 and eta1 insertion to bind Rab9A., [RefSeq, PubMed]; Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as a GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B., [UniProtKB, UniProtKB]; Overall, the expression pattern of NuIP in adult mouse brain suggests that it may be involved in motor activity control in basal ganglia as well as higher central nervous system (CNS) functions such as cognition and memory in cortex and hippocampus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJ12", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BPQ7-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UR97-1", "uniprot_id": [ { "id": "SNX21_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UR97", "type": "external" } ], "mass": 40308.0, "length": 363, "protein_name": "Sorting nexin-21", "gene_name": "Snx21", "organism": "Mouse", "refseq_name": "sorting nexin-21 isoform 1", "refseq_ac": [ { "id": "NP_598685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598685", "type": "external" } ], "gene_names_uniprotkb": "Snx21", "gene_names_refseq": "5730407K14Rik; Snx21", "protein_names_uniprotkb": "Sorting nexin-21", "protein_names_refseq": "sorting nexin-21 isoform 1; sorting nexin-21", "tax_id": 10090, "disease": "", "pathway": " (mmu:101113)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25882846;31219806;32848054;40885482", "class_list": "", "function": "Binds to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate (PubMed:25882846). May be involved in several stages of intracellular trafficking., [UniProtKB, PubMed]; SAXS solution structures of SNX20 and SNX21 show that the proteins adopt a compact globular architecture; membrane interaction analyses indicate the presence of phosphoinositide -binding sites that may regulate their intracellular localization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:1901981 phosphatidylinositol phosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0031901 early endosome membrane", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3UR97-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97868-1", "uniprot_id": [ { "id": "RBBP6_MOUSE", "url": "https://www.uniprot.org/uniprot/P97868", "type": "external" } ], "mass": 199587.0, "length": 1790, "protein_name": "E3 ubiquitin-protein ligase RBBP6", "gene_name": "Rbbp6", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RBBP6 isoform 1", "refseq_ac": [ { "id": "NP_035377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035377", "type": "external" } ], "gene_names_uniprotkb": "Rbbp6; P2pr; Pact", "gene_names_refseq": "4933422O15Rik; C030034J04Rik; P2P-R; PACT; Rbbp6", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RBBP6; 2.3.2.27; Proliferation potential-related protein; Protein P2P-R; RING-type E3 ubiquitin transferase RBBP6; Retinoblastoma-binding protein 6; p53-associated cellular protein of testis", "protein_names_refseq": "E3 ubiquitin-protein ligase RBBP6 isoform 1; E3 ubiquitin-protein ligase RBBP6; RING-type E3 ubiquitin transferase RBBP6; p53-associated cellular protein of testis; proliferation potential-related protein; protein P2P-R; retinoblastoma-binding protein 6", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:19647); (R-MMU-9013422); (R-MMU-9770562); (R-MMU-983168)", "pathway_count": 4, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;12064457;12384997;14566974;15617101;17242355;17470788;19144319;21183079;21750661;22645316;23806337;24726359;25428506;30084848;31219806;34428180;40997131;9010216;9037032", "class_list": "", "function": "E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (By similarity). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth retardation (PubMed:17470788). Regulates DNA-replication and common fragile sites (CFS) stability in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359)., [UniProtKB, PubMed, PubMed, UniProtKB]; P2P-R expression may be translationally regulated by PUM2 and that P2P-R may modulate translation by influencing ribosomal protein gene expression, [RefSeq, PubMed]; The PACT-p53 interaction plays a critical role in embryonic development and tumorigenesis and identify PACT as a member of negative regulators of p53., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P70287;Q3TTR9;Q3TUM7;Q3UMP7;Q4U217;Q7TT06;Q8BNY8;Q8R399", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0003676 nucleic acid binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005813 centrosome;GO:0016607 nuclear speck;GO:0005694 chromosome", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006397 mRNA processing;GO:0035264 multicellular organism growth;GO:0006260 DNA replication;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P97868-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CG46-1", "uniprot_id": [ { "id": "SMC5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CG46", "type": "external" } ], "mass": 128813.0, "length": 1101, "protein_name": "Structural maintenance of chromosomes protein 5", "gene_name": "Smc5", "organism": "Mouse", "refseq_name": "structural maintenance of chromosomes protein 5 isoform 1", "refseq_ac": [ { "id": "NP_001239613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239613", "type": "external" } ], "gene_names_uniprotkb": "Smc5; Kiaa0594; Smc5l1", "gene_names_refseq": "MLZ-453; SMC-5; Smc5l1; Smc5; mKIAA0594; mSMC5", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein 5; MLZ-453; Protein expressed in male leptotene and zygotene spermatocytes 453; SMC protein 5; SMC-5; mSMC5", "protein_names_refseq": "SMC protein 5; SMC5 structural maintenance of chromosomes 5-like 1; protein expressed in male leptotene and zygotene spermatocytes 453; structural maintenance of chromosomes protein 5 isoform 1; structural maintenance of chromosomes protein 5", "tax_id": 10090, "disease": "mosaic variegated aneuploidy syndrome (Disease Ontology:DOID:0080688)", "pathway": " (mmu:226026); (R-MMU-3108214)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11408570;14660695;20339383;21750661;25605945;31147908;33200984;34428180", "class_list": "", "function": "Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6 (By similarity)., [UniProtKB]; SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Study the function and properties of the SMC5/6 complex in mammals., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80TW7;Q8CHX5;Q922K3", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0003697 single-stranded DNA binding;GO:0000217 DNA secondary structure binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0030054 cell junction;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0051984 positive regulation of chromosome segregation;GO:0044772 mitotic cell cycle phase transition;GO:0071459 protein localization to chromosome, centromeric region;GO:0007059 chromosome segregation;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8CG46-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AKQ0-1", "uniprot_id": [ { "id": "S35D1_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AKQ0", "type": "external" } ], "mass": 39272.0, "length": 355, "protein_name": "Nucleotide sugar transporter SLC35D1", "gene_name": "Slc35d1", "organism": "Mouse", "refseq_name": "nucleotide sugar transporter SLC35D1 isoform 2", "refseq_ac": [ { "id": "NP_808400", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808400", "type": "external" } ], "gene_names_uniprotkb": "Slc35d1", "gene_names_refseq": "C330011J09; Slc35d1; UGTREL7; mKIAA0260", "protein_names_uniprotkb": "Nucleotide sugar transporter SLC35D1; Solute carrier family 35 member D1; UDP-GlcA/UDP-GalNAc transporter; UDP-galactose transporter-related protein 7; UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter; UGTrel7", "protein_names_refseq": "UDP-GlcA/UDP-GalNAc transporter; UDP-galactose transporter-related protein 7; UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter; nucleotide sugar transporter SLC35D1 isoform 2; nucleotide sugar transporter SLC35D1; solute carrier family 35 member D1", "tax_id": 10090, "disease": "schneckenbecken dysplasia (Disease Ontology:DOID:0050775); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:242585); (R-MMU-173599); (R-MMU-727802)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "17952091;21750661;25605945;40997131", "class_list": "glycogene", "function": "Antiporter that transports nucleotide sugars across the endoplasmic reticulum (ER) membrane in exchange for either their cognate nucleoside monophosphate or another nucleotide sugar (By similarity). Transports various UDP-sugars including UDP-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc), UDP-N-acetyl-alpha-D-galactosamine (UDP-GalNAc) and UDP-alpha-D-glucuronate (UDP-GlcA), which are used by ER glucosyltransferases as sugar donors for the synthesis of sugar chains of glycoproteins, glycolipids and oligosaccharides (By similarity). May couple UDP-GlcNAc or UDP-GalNAc efflux to UDP-GlcA influx into the ER lumen that in turn stimulates glucuronidation and subsequent excretion of endobiotics and xenobiotics (By similarity). Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development., [UniProtKB, PubMed, UniProtKB]; Deficient mice develop a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TE90;Q5DU40;Q8BKX2;Q8BX24", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity;GO:0005461 UDP-glucuronate transmembrane transporter activity;GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity;GO:0005463 UDP-N-acetylgalactosamine transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0090481 pyrimidine nucleotide-sugar transmembrane transport;GO:0048706 embryonic skeletal system development;GO:0015780 nucleotide-sugar transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A2AKQ0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P8X1-1", "uniprot_id": [ { "id": "SNX6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P8X1", "type": "external" } ], "mass": 46649.0, "length": 406, "protein_name": "Sorting nexin-6", "gene_name": "Snx6", "organism": "Mouse", "refseq_name": "sorting nexin-6 isoform 1", "refseq_ac": [ { "id": "NP_081274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081274", "type": "external" } ], "gene_names_uniprotkb": "Snx6", "gene_names_refseq": "2010006G21Rik; 2610032J07Rik; 2810425K19Rik; Snx6", "protein_names_uniprotkb": "Sorting nexin-6", "protein_names_refseq": "sorting nexin-6 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72183)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "18523162;20228253;21750661;22872234;25428506;25535984;28134614;29666193;31219806;34418053;34428180;36210013", "class_list": "", "function": "Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity (By similarity). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C-mediated E-cadherin degradation (By similarity). In association with GIT1 involved in EGFR degradation (PubMed:18523162). Promotes lysosomal degradation of CDKN1B (PubMed:20228253). May contribute to transcription regulation (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; The authors show that SNX6 functions independently of retromer to regulate distribution of Homer1b/c in the dendritic shaft. Publication Status: Online-Only, [RefSeq, PubMed]; These data demonstrate an endosomal, EGF-regulated interaction between SNX6 and GIT1 that enhances degradation of the EGFR, and thereby alters EGFR signaling., [RefSeq, PubMed]; These results identify SNX6 as a key regulator of lamin A synthesis and incorporation into the nuclear envelope. Publication Status: Online-Only, [RefSeq, PubMed]; This study identified sorting nexin 6 (SNX6), an endosomal sorting component and BAR domain-containing protein, as a host cell interactor of Lmol656., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZ03", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0035091 phosphatidylinositol binding;GO:0034452 dynactin binding;GO:0034713 type I transforming growth factor beta receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol", "go_biological_process": "GO:0006886 intracellular protein transport;GO:1904646 cellular response to amyloid-beta;GO:0045892 negative regulation of DNA-templated transcription;GO:0043524 negative regulation of neuron apoptotic process;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q6P8X1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91W98-1", "uniprot_id": [ { "id": "S15A4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91W98", "type": "external" } ], "mass": 62256.0, "length": 574, "protein_name": "Solute carrier family 15 member 4", "gene_name": "Slc15a4", "organism": "Mouse", "refseq_name": "solute carrier family 15 member 4", "refseq_ac": [ { "id": "NP_598656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598656", "type": "external" } ], "gene_names_uniprotkb": "Slc15a4; Pht1", "gene_names_refseq": "C130069N12Rik; PHT1; PTR4; Slc15a4", "protein_names_uniprotkb": "Solute carrier family 15 member 4; Peptide/histidine transporter 1", "protein_names_refseq": "peptide transporter 4; peptide-histidine transporter 4; peptide/histidine transporter 1; solute carrier family 15 member 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:100561); (R-MMU-427975); (R-MMU-6798695); (R-MMU-9860276)", "pathway_count": 4, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;18250455;19144319;19570976;21045126;21183079;21277849;21750661;23028315;23382217;24695226;25238095;25310967;27845049;29155995;29187734;29305823;29784761;30262916;31219806;33444326;34428180;35349343;35984892;36031853;37828378", "class_list": "", "function": "Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response (PubMed:19570976, PubMed:21277849, PubMed:25238095, PubMed:27845049, PubMed:29305823). Preferably binds to short peptides with a basic residue at the first position and a hydrophobic residue at the second position (By similarity). Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (PubMed:29784761). Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand (PubMed:19570976, PubMed:23028315, PubMed:24695226, PubMed:25238095, PubMed:29784761). Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs) (PubMed:21045126, PubMed:23382217, PubMed:25238095, PubMed:30262916). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (By similarity). Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation (PubMed:25310967). Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (PubMed:29155995)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; SLC15A4 promotes colitis through Toll-like receptor 9 and NOD1-dependent innate immune responses., [RefSeq, PubMed]; The identification of the feeble mutation led to our subsequent observations that AP-3, as well as the BLOC-1 and BLOC-2 are essential for plasmacytoid dendritic cells signaling through TLR7 and TLR9., [RefSeq, PubMed]; The peptide symporter SLC15a4 is essential for the development of systemic lupus erythematosus in murine models. Publication Status: Online-Only, [RefSeq, PubMed]; The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and autophagy restraint in dendritic cells., [RefSeq, PubMed]; The solute carrier SLC15A4 is required for optimal trafficking of nucleic acid-sensing TLRs and ligands to endolysosomes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPL5", "ec_number_list": [], "go_molecular_function": "GO:0005290 L-histidine transmembrane transporter activity;GO:0015333 peptide:proton symporter activity;GO:0071916 dipeptide transmembrane transporter activity;GO:0015647 peptidoglycan transmembrane transporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0031901 early endosome membrane;GO:0010008 endosome membrane;GO:0036020 endolysosome membrane", "go_biological_process": "GO:0048302 regulation of isotype switching to IgG isotypes;GO:0070430 positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0015031 protein transport;GO:0045087 innate immune response;GO:0034157 positive regulation of toll-like receptor 7 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q91W98-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811P8-1", "uniprot_id": [ { "id": "RHG32_MOUSE", "url": "https://www.uniprot.org/uniprot/Q811P8", "type": "external" } ], "mass": 229719.0, "length": 2089, "protein_name": "Rho GTPase-activating protein 32", "gene_name": "Arhgap32", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 32 isoform 1", "refseq_ac": [ { "id": "NP_001182561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182561", "type": "external" } ], "gene_names_uniprotkb": "Arhgap32; Grit; Kiaa0712; Rics", "gene_names_refseq": "3426406O18Rik; Arhgap32; Gc-gap; Grit; Px-rics; Rics; mKIAA0712; p200Rhogap; p250Gap", "protein_names_uniprotkb": "Rho GTPase-activating protein 32; Brain-specific Rho GTPase-activating protein; GAB-associated Cdc42/Rac GTPase-activating protein; GC-GAP; Rho-type GTPase-activating protein 32; Rho/Cdc42/Rac GTPase-activating protein RICS; RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling; p200RhoGAP; p250GAP", "protein_names_refseq": "GAB-associated Cdc42/Rac GTPase-activating protein; GTPase-activating protein for Cdc42 and Rac1; Rho GTPase activating protein 33 pseudogene; brain-specific Rho GTPase-activating protein; rac GTPase activating protein; rho GTPase-activating protein 32 isoform 1; rho-type GTPase-activating protein 32; rho/Cdc42/Rac GTPase-activating protein RICS; rhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:330914); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013408); (R-MMU-9013409); (R-MMU-9013423); (R-MMU-9035034); (R-MMU-9768727)", "pathway_count": 13, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;12454018;12531901;12819203;12857875;16452087;16716191;17242355;17272280;17663722;21183079;21750661;22517741;22645316;24129315;27609886;30045817;31616917;33300544;34678516;36852467;40021952;40885482", "class_list": "", "function": "GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Our results suggest that PX-RICS-mediated GABAAR trafficking is a key target for GABAergic plasticity and its dysfunction leads to atypical emotional processing underlying autism., [RefSeq, PubMed]; P200 RhoGAP can mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation, [RefSeq, PubMed]; RICS may regulate dendritic spine morphology and strength by modulating Rho GTPases [RICS], [RefSeq, PubMed]; RICS plays an important role in neurite extension, [RefSeq, PubMed]; These results suggest that PX-RICS is involved in early brain development including extension of axons and dendrites, and postnatal remodeling and fine-tuning of neural circuits., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 13, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 13, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 13, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "B9EHJ8;Q6A010", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:1901981 phosphatidylinositol phosphate binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0007266 Rho protein signal transduction;GO:0007264 small GTPase-mediated signal transduction;GO:0045773 positive regulation of axon extension;GO:0061001 regulation of dendritic spine morphogenesis;GO:2001224 positive regulation of neuron migration", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "Q811P8-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DB90-1", "uniprot_id": [ { "id": "SMG9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DB90", "type": "external" } ], "mass": 57621.0, "length": 520, "protein_name": "Nonsense-mediated mRNA decay factor SMG9", "gene_name": "Smg9", "organism": "Mouse", "refseq_name": "nonsense-mediated mRNA decay factor SMG9 isoform 1", "refseq_ac": [ { "id": "NP_082323", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082323", "type": "external" } ], "gene_names_uniprotkb": "Smg9; 1500002O20Rik", "gene_names_refseq": "1500002O20Rik; Smg9", "protein_names_uniprotkb": "Nonsense-mediated mRNA decay factor SMG9", "protein_names_refseq": "nonsense-mediated mRNA decay factor SMG9 isoform 1; nonsense-mediated mRNA decay factor SMG9; protein SMG9; protein smg-9 homolog; smg-9 homolog, nonsense mediated mRNA decay factor", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:71997); (R-MMU-975957)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;25428506;27018474;31219806;34428180", "class_list": "", "function": "Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (By similarity). Plays a role in brain, heart, and eye development (PubMed:27018474)., [UniProtKB, UniProtKB, PubMed]; Mutations in SMG9 cause a multiple congenital anomaly syndrome in humans and mice, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTB9;Q8BYJ3", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:1902554 serine/threonine protein kinase complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007507 heart development;GO:0043066 negative regulation of apoptotic process;GO:0007420 brain development;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9DB90-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64FW2-1", "uniprot_id": [ { "id": "RETST_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64FW2", "type": "external" } ], "mass": 67334.0, "length": 609, "protein_name": "All-trans-retinol 13,14-reductase", "gene_name": "Retsat", "organism": "Mouse", "refseq_name": "all-trans-retinol 13,14-reductase precursor", "refseq_ac": [ { "id": "NP_080435", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080435", "type": "external" } ], "gene_names_uniprotkb": "Retsat; Ppsig", "gene_names_refseq": "0610039N19Rik; MMT-7; Ppsig; Retsat", "protein_names_uniprotkb": "All-trans-retinol 13,14-reductase; 1.3.99.23; All-trans-13,14-dihydroretinol saturase; PPAR-alpha-regulated and starvation-induced gene protein; RetSat", "protein_names_refseq": "PPAR-alpha-regulated and starvation-induced gene protein; all-trans-13,14-dihydroretinol saturase; all-trans-retinol 13,14-reductase precursor; all-trans-retinol 13,14-reductase", "tax_id": 10090, "disease": "", "pathway": " (mmu:67442)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11753649;15358783;17253779;17664141;18179220;18289917;19139408;19940255;21750661;28855500;31219806;34428180;38895981", "class_list": "", "function": "Catalyzes the saturation of all-trans-retinol to all-trans-13,14-dihydroretinol (PubMed:15358783, PubMed:17253779, PubMed:19139408). Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers (PubMed:15358783). May play a role in the metabolism of vitamin A (PubMed:15358783, PubMed:17253779). Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP (PubMed:28855500). Required for adipocyte differentiation in a 3T3-L1 cell culture model (PubMed:19139408). This effect does not seem to mimic the in vivo situation in which animals show increased adiposity in the absence of RETSAT (PubMed:19940255)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Here, we report the identification and characterization of Ppsig (for PPARalpha-regulated and starvation-induced gene) with unknown biological function from mouse liver, [RefSeq, PubMed]; Intestinal retinol saturase is implicated in the development of obesity and epithelial homeostasis upon injury., [RefSeq, PubMed]; Mouse RetSat catalyzes the stereospecific saturation of the C13-C14 double bond of all-trans-retinol to produce (13R)-all-trans-13,14-dihydroretinol., [RefSeq, PubMed]; Suggest a novel role for retinol saturase in regulating sensitivity to oxidative stress, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q149J8;Q3UNN9;Q78JX8;Q8VHE7;Q9CW85", "ec_number_list": [ { "id": "1.3.99.23", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.99.23", "type": "external" } ], "go_molecular_function": "GO:0051786 all-trans-retinol 13,14-reductase activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0042572 retinol metabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q64FW2-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NZC7-1", "uniprot_id": [ { "id": "S23IP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NZC7", "type": "external" } ], "mass": 110780.0, "length": 998, "protein_name": "SEC23-interacting protein", "gene_name": "Sec23ip", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sec23ip", "gene_names_refseq": "", "protein_names_uniprotkb": "SEC23-interacting protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "hereditary spastic paraplegia 28 (Disease Ontology:DOID:0110779); hereditary spastic paraplegia 54 (Disease Ontology:DOID:0110806); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:207352); (R-MMU-204005)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "21183079;21750661;22645316;25153642;26495903;28528544;32782141;33300544;33725478;34428180;34678516;35822049;37828378;39627609;40885482;40997131", "class_list": "", "function": "Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BXY6", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004620 phospholipase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0048471 perinuclear region of cytoplasm;GO:0097038 perinuclear endoplasmic reticulum", "go_biological_process": "GO:0007286 spermatid development;GO:0007338 single fertilization;GO:0001675 acrosome assembly;GO:0010256 endomembrane system organization", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q6NZC7-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BNN1-1", "uniprot_id": [ { "id": "SPA2L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BNN1", "type": "external" } ], "mass": 46772.0, "length": 426, "protein_name": "Spermatogenesis-associated protein 2-like protein", "gene_name": "Spata2l", "organism": "Mouse", "refseq_name": "spermatogenesis-associated protein 2-like protein isoform 1", "refseq_ac": [ { "id": "NP_084452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084452", "type": "external" } ], "gene_names_uniprotkb": "Spata2l; Kiaa4138", "gene_names_refseq": "2610039E05Rik; Spata2l", "protein_names_uniprotkb": "Spermatogenesis-associated protein 2-like protein; SPATA2-like protein", "protein_names_refseq": "SPATA2-like protein; spermatogenesis-associated protein 2-like protein isoform 1; spermatogenesis-associated protein 2-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:78779)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;33300544", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UTL5;Q5DTL7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BNN1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VU8-1", "uniprot_id": [ { "id": "PTOV1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VU8", "type": "external" } ], "mass": 46865.0, "length": 416, "protein_name": "Prostate tumor-overexpressed gene 1 protein homolog", "gene_name": "Ptov1", "organism": "Mouse", "refseq_name": "prostate tumor-overexpressed gene 1 protein homolog", "refseq_ac": [ { "id": "NP_598710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598710", "type": "external" } ], "gene_names_uniprotkb": "Ptov1", "gene_names_refseq": "1110030G05Rik; Gcap3; Ptov1", "protein_names_uniprotkb": "Prostate tumor-overexpressed gene 1 protein homolog", "protein_names_refseq": "granule cell antiserum positive 3; prostate tumor-overexpressed gene 1 protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:84113)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21678139;21750661", "class_list": "", "function": "Activates transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation., [UniProtKB, UniProtKB]; PTOV1 is associated with UCH-L1 and in response to estrogen stimuli during the mouse oocyte development, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CTC2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005667 transcription regulator complex;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91VU8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C7R7-1", "uniprot_id": [ { "id": "RFX6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C7R7", "type": "external" } ], "mass": 102566.0, "length": 927, "protein_name": "DNA-binding protein RFX6", "gene_name": "Rfx6", "organism": "Mouse", "refseq_name": "DNA-binding protein RFX6 isoform 1", "refseq_ac": [ { "id": "NP_001152861", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152861", "type": "external" } ], "gene_names_uniprotkb": "Rfx6; Rfxdc1", "gene_names_refseq": "4930572O07Rik; Rfx6; Rfxdc1", "protein_names_uniprotkb": "DNA-binding protein RFX6; Regulatory factor X 6; Regulatory factor X domain-containing protein 1", "protein_names_refseq": "DNA-binding protein RFX6 isoform 1; DNA-binding protein RFX6; regulatory factor X domain containing 1; regulatory factor X domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:320995)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20040487;20148032;21750661;22872234;30509498;31668390", "class_list": "", "function": "Rfx6 can directly bind to upstream of MiR-145, MiR-195, and possibly other non-protein-coding functional RNAs to control adult mouse pancreatic differentiation. Interestingly, our study revealed that Rfx6 played an important role in insulin translation by binding to the Eif2ak1, Upf1, and Eif5., [RefSeq, PubMed]; Rfx6 is found in postmitotic islet progenitor cells in the embryo and is maintained in all developing and adult islet cell types. It is dependent on Ngn3 and during islet cell differentiation., [RefSeq, PubMed]; Rfx6 operates upstream of Arx, Pax6 and Isl1 to trigger the differentiation of peptidergic enteroendocrine cells such as GIP-, GLP-1-, or CCK-secreting cells. On the contrary, Rfx6 represses Lmx1a and Tph1, two genes essential for serotonin biosynthesis., [RefSeq, PubMed]; Studies demonstrate a unique position for Rfx6 in the hierarchy of factors that coordinate pancreatic islet development in both mice and humans, [RefSeq, PubMed]; Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032). Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CDN5", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8C7R7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PIX5-1", "uniprot_id": [ { "id": "RHDF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PIX5", "type": "external" } ], "mass": 97292.0, "length": 856, "protein_name": "Inactive rhomboid protein 1", "gene_name": "Rhbdf1", "organism": "Mouse", "refseq_name": "inactive rhomboid protein 1 isoform 1", "refseq_ac": [ { "id": "NP_034247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034247", "type": "external" } ], "gene_names_uniprotkb": "Rhbdf1; Dist1; Irhom1; Kiaa4242", "gene_names_refseq": "C16ORF8; Dist1; Dist; Egfr-rs; Rhbdf1; mKIAA4242", "protein_names_uniprotkb": "Inactive rhomboid protein 1; Epidermal growth factor receptor-related protein; Rhomboid family member 1; iRhom1", "protein_names_refseq": "epidermal growth factor receptor related sequence; epidermal growth factor receptor-related protein; iRhom1; inactive rhomboid protein 1 isoform 1; inactive rhomboid protein 1; rhomboid family 1; rhomboid family member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:13650)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11157800;21183079;21439629;21750661;30899004;31219806;34428180;34613632;34672089;8318735", "class_list": "", "function": "IRhom1 rescues cognitive dysfunction in multiple sclerosis via preventing myelin injury., [RefSeq, PubMed]; Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AVE2;Q04843;Q5DTF4;Q6PJ49;Q8VIK0", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0050709 negative regulation of protein secretion;GO:0008283 cell population proliferation;GO:0016477 cell migration;GO:0050708 regulation of protein secretion;GO:0042058 regulation of epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q6PIX5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJF2-1", "uniprot_id": [ { "id": "SPAG4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJF2", "type": "external" } ], "mass": 48582.0, "length": 443, "protein_name": "Sperm-associated antigen 4 protein", "gene_name": "Spag4", "organism": "Mouse", "refseq_name": "sperm-associated antigen 4 protein", "refseq_ac": [ { "id": "NP_631890", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631890", "type": "external" } ], "gene_names_uniprotkb": "Spag4; MNCb-0953; Sun4", "gene_names_refseq": "1700041K21Rik; MNCb-0953; Spag4; Sun4; mKIAA4118", "protein_names_uniprotkb": "Sperm-associated antigen 4 protein; Outer dense fiber-associated protein SPAG4; SUN domain-containing protein 4", "protein_names_refseq": "SUN domain-containing protein 4; outer dense fiber-associated protein SPAG4; sperm antigen 4; sperm-associated antigen 4 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:245865)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10373309;21750661;26417726;26621829;29663073", "class_list": "", "function": "Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity. May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail., [UniProtKB, PubMed]; SUN4, a spermatid nuclear membrane protein has an essential function in coupling the manchette to the nuclear periphery., [RefSeq, PubMed]; The results thus indicate that SPAG4, albeit not essential for the formation of the HTCA per se, is, nevertheless, required for tightening the sperm head-to-tail anchorage by provoking the correct attachment of the lateral parts of the basal plate to the implantation fossa., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A3KGK4", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005874 microtubule;GO:0005637 nuclear inner membrane;GO:0034993 meiotic nuclear membrane microtubule tethering complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JJF2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91V14-1", "uniprot_id": [ { "id": "S12A5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91V14", "type": "external" } ], "mass": 126271.0, "length": 1138, "protein_name": "Solute carrier family 12 member 5", "gene_name": "Slc12a5", "organism": "Mouse", "refseq_name": "solute carrier family 12 member 5 isoform 3", "refseq_ac": [ { "id": "NP_065066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065066", "type": "external" } ], "gene_names_uniprotkb": "Slc12a5; Kcc2; Kiaa1176", "gene_names_refseq": "KCC2; Slc12a5; mKIAA1176", "protein_names_uniprotkb": "Solute carrier family 12 member 5; Electroneutral potassium-chloride cotransporter 2; K-Cl cotransporter 2; Neuronal K-Cl cotransporter; mKCC2", "protein_names_refseq": "K-Cl cotransporter 2; electroneutral potassium-chloride cotransporter 2; mKCC2; neuronal K-Cl cotransporter; solute carrier family 12 member 5 isoform 3", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 34 (Disease Ontology:DOID:0080460); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:57138); (R-MMU-426117)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10077537;11395011;11471062;11701957;17715129;18625303;19665974;21183079;21750661;22645316;22872234;25605945;30899004;33300544;33597714;34428180;38788828", "class_list": "", "function": "Chromosomal localization of SLC12A5/Slc12a5, the human and mouse genes for the neuron-specific K(+)-Cl(-) cotransporter (KCC2) defines a new region of conserved homology. Erratum:[Cytogenet Cell Genet. 2002;98(2-3):232], [RefSeq, PubMed]; Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis (By similarity). As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Reduced Gene Expression of KCC2 Accelerates Axonal Regeneration and Reduces Motor Dysfunctions after Tibial Nerve Severance and Suturing., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 14, "disease_count": 2, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A2A5L0;Q3UHQ2;Q7TQC9;Q80TI5;Q9Z0M7", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0008519 ammonium channel activity;GO:0015108 chloride transmembrane transporter activity;GO:0015379 potassium:chloride symporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043025 neuronal cell body;GO:0043198 dendritic shaft", "go_biological_process": "GO:0030644 intracellular chloride ion homeostasis;GO:0006811 monoatomic ion transport;GO:0007612 learning;GO:0007268 chemical synaptic transmission;GO:0006884 cell volume homeostasis", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "Q91V14-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AVJ5-1", "uniprot_id": [ { "id": "PRR5L_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AVJ5", "type": "external" } ], "mass": 40982.0, "length": 370, "protein_name": "Proline-rich protein 5-like", "gene_name": "Prr5l", "organism": "Mouse", "refseq_name": "proline-rich protein 5-like", "refseq_ac": [ { "id": "NP_001077279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077279", "type": "external" } ], "gene_names_uniprotkb": "Prr5l; Protor2", "gene_names_refseq": "2600010E01Rik; 4833411O04Rik; Protor-2; Protor2; Prr5l", "protein_names_uniprotkb": "Proline-rich protein 5-like; Protein observed with Rictor-2; Protor-2", "protein_names_refseq": "proline-rich protein 5-like; protein observed with Rictor-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72446)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21750661;22609986;31219806;34428180", "class_list": "", "function": "Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (By similarity). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF and GM-CSF, in response to stress. Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress., [UniProtKB, UniProtKB, PubMed]; PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12 in fibroblasts and pulmonary fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZWM2;Q80Y78;Q8BIT0", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031932 TORC2 complex", "go_biological_process": "GO:0010762 regulation of fibroblast migration;GO:0001934 positive regulation of protein phosphorylation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0090316 positive regulation of intracellular protein transport;GO:0001933 negative regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A2AVJ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35963-1", "uniprot_id": [ { "id": "RB33B_MOUSE", "url": "https://www.uniprot.org/uniprot/O35963", "type": "external" } ], "mass": 25767.0, "length": 229, "protein_name": "Ras-related protein Rab-33B", "gene_name": "Rab33b", "organism": "Mouse", "refseq_name": "ras-related protein Rab-33B", "refseq_ac": [ { "id": "NP_058554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058554", "type": "external" } ], "gene_names_uniprotkb": "Rab33b", "gene_names_refseq": "Rab33b", "protein_names_uniprotkb": "Ras-related protein Rab-33B; 3.6.5.2", "protein_names_refseq": "RAB33B, member of RAS oncogene family; ras-related protein Rab-33B", "tax_id": 10090, "disease": "Smith-McCort dysplasia 2 (Disease Ontology:DOID:0081271)", "pathway": " (mmu:19338); (R-MMU-6811438); (R-MMU-8854214); (R-MMU-8873719)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "16034420;16855591;18448665;21750661;22082872;32737358;34428180;9512502", "class_list": "", "function": "Crystal structure of the Rab33B/Atg16L1 effector complex. Publication Status: Online-Only, [RefSeq, PubMed]; Rab33 modulates autophagosome formation through interaction with Atg16L, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:16855591). RAB33B acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking (By similarity). Participates in autophagosome formation by recruiting the ATG12-ATG5-ATG16L1 complex to phagophores, probably in a nucleotide-independent manner (PubMed:18448665)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TWI8", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005796 Golgi lumen;GO:0034045 phagophore assembly site membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0015031 protein transport;GO:0034497 protein localization to phagophore assembly site;GO:0048705 skeletal system morphogenesis;GO:0034067 protein localization to Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O35963-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C5L7-1", "uniprot_id": [ { "id": "RBM34_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C5L7", "type": "external" } ], "mass": 49116.0, "length": 442, "protein_name": "RNA-binding protein 34", "gene_name": "Rbm34", "organism": "Mouse", "refseq_name": "RNA-binding protein 34 isoform 1", "refseq_ac": [ { "id": "NP_766350", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766350", "type": "external" } ], "gene_names_uniprotkb": "Rbm34; D8Ertd233e", "gene_names_refseq": "4930547K05Rik; 6330444B11; D8Ertd233e; Rbm34", "protein_names_uniprotkb": "RNA-binding protein 34; RNA-binding motif protein 34", "protein_names_refseq": "RNA-binding protein 34 isoform 1; RNA-binding protein 34", "tax_id": 10090, "disease": "", "pathway": " (mmu:52202)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;23806337", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RUP0", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005694 chromosome", "go_biological_process": "GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C5L7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AU37-1", "uniprot_id": [ { "id": "RD21L_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AU37", "type": "external" } ], "mass": 62670.0, "length": 552, "protein_name": "Double-strand-break repair protein rad21-like protein 1", "gene_name": "Rad21l1; Rad21l", "organism": "Mouse", "refseq_name": "double-strand-break repair protein rad21-like protein 1", "refseq_ac": [ { "id": "NP_001263329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263329", "type": "external" } ], "gene_names_uniprotkb": "Rad21l1; Rad21l; Gm14160; Rad21l", "gene_names_refseq": "Gm14160; MeiRAD21L; Rad21l1; Rad21l", "protein_names_uniprotkb": "Double-strand-break repair protein rad21-like protein 1", "protein_names_refseq": "double-strand-break repair protein rad21-like protein 1", "tax_id": 10090, "disease": "Cornelia de Lange syndrome 4 (Disease Ontology:DOID:0080508)", "pathway": " (mmu:668929)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21242291;21274006;21527826;21743440;21750661;22711701;28239026", "class_list": "", "function": "Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I. Not required for meiosis in females in young mice, while it is required later as mice age., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; RAD21L is identified as a novel subunit of the cohesin complex with homology to the RAD21/REC8/alpha-kleisin subfamily expressed in mouse testis., [RefSeq, PubMed]; Study identifes a new mammalian cohesin subunit, RAD21L, with sequence similarity to RAD21 and REC8; RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21, [RefSeq, PubMed]; The results suggest that cohesin complexes containing RAD21L may be involved in synapsis initiation and crossover recombination between homologous chromosomes., [RefSeq, PubMed]; These results provide in vivo evidence that RAD21L is essential for male fertility and in females for the maintenance of fertility during natural aging. Publication Status: Online-Only, [RefSeq, PubMed]; When ectopically expressed in somatic cells, can promote homologous chromosome adjacency, which resembles the homolog pairing normally seen during meiosis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E5RTP6;F6KST0", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0030893 meiotic cohesin complex;GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005694 chromosome;GO:0008278 cohesin complex", "go_biological_process": "GO:0007059 chromosome segregation;GO:0051321 meiotic cell cycle;GO:0007062 sister chromatid cohesion;GO:1990414 replication-born double-strand break repair via sister chromatid exchange", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A2AU37-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6A0D4-1", "uniprot_id": [ { "id": "RFTN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6A0D4", "type": "external" } ], "mass": 61537.0, "length": 554, "protein_name": "Raftlin", "gene_name": "Rftn1", "organism": "Mouse", "refseq_name": "raftlin", "refseq_ac": [ { "id": "NP_852062", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852062", "type": "external" } ], "gene_names_uniprotkb": "Rftn1; Kiaa0084", "gene_names_refseq": "2310015N21Rik; Rftn1", "protein_names_uniprotkb": "Raftlin; Raft-linking protein", "protein_names_refseq": "raft-linking protein; raftlin", "tax_id": 10090, "disease": "glaucoma (Disease Ontology:DOID:1686)", "pathway": " (mmu:76438)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12805216;19144319;19414744;21183079;21266579;21750661;26495903;27022195;34428180;37507081", "class_list": "", "function": "Involved in protein trafficking via association with clathrin and AP2 complex (By similarity). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages, and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (PubMed:19414744). May regulate B-cell antigen receptor-mediated signaling (By similarity). May play a pivotal role in the formation and/or maintenance of lipid rafts (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Raftlin cooperates with the uptake receptor to mediate cell entry of poly(I:C), which is critical for activation of TLR3., [RefSeq, PubMed]; This study shows that raftlin appears to modulate cargo selection as an accessary protein of clathrin-associated adaptor protein-2 in clathrin-mediated endocytosis of TLR3/4 ligands, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U654;Q3U8P6;Q80US1", "ec_number_list": [], "go_molecular_function": "GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0002457 T cell antigen processing and presentation;GO:0032740 positive regulation of interleukin-17 production;GO:0050852 T cell receptor signaling pathway;GO:0050853 B cell receptor signaling pathway;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6A0D4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09009-1", "uniprot_id": [ { "id": "RFNG_MOUSE", "url": "https://www.uniprot.org/uniprot/O09009", "type": "external" } ], "mass": 36926.0, "length": 332, "protein_name": "Beta-1,3-N-acetylglucosaminyltransferase radical fringe", "gene_name": "Rfng", "organism": "Mouse", "refseq_name": "beta-1,3-N-acetylglucosaminyltransferase radical fringe", "refseq_ac": [ { "id": "NP_033079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033079", "type": "external" } ], "gene_names_uniprotkb": "Rfng", "gene_names_refseq": "Rfng", "protein_names_uniprotkb": "Beta-1,3-N-acetylglucosaminyltransferase radical fringe; 2.4.1.222; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase", "protein_names_refseq": "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; beta-1,3-N-acetylglucosaminyltransferase radical fringe; radical fringe gene homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:19719)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10341080;16221665;28089369;9187150;9207795", "class_list": "glycogene;glycosyltransferase", "function": "Fringe modifications at EGF8 and EGF12 enhanced Notch1 binding to and activation from Delta-like 1, while modifications at EGF6 and EGF36 (added by Manic and Lunatic but not Radical) inhibited Notch1 activation from Jagged1., [RefSeq, PubMed]; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1 (PubMed:28089369). May be involved in limb formation and in neurogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1ATU3", "ec_number_list": [ { "id": "2.4.1.222", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.222", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045747 positive regulation of Notch signaling pathway;GO:0007389 pattern specification process;GO:0045746 negative regulation of Notch signaling pathway", "synthesized_glycan_count": 19, "hit_score": 0.9, "record_id": "O09009-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.100.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88667-1", "uniprot_id": [ { "id": "RAD_MOUSE", "url": "https://www.uniprot.org/uniprot/O88667", "type": "external" } ], "mass": 33279.0, "length": 308, "protein_name": "GTP-binding protein RAD", "gene_name": "Rrad", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rrad", "gene_names_refseq": "", "protein_names_uniprotkb": "GTP-binding protein RAD", "protein_names_refseq": "", "tax_id": 10090, "disease": "congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": "", "pathway_count": 0, "publication_count": 8, "publication_id_list": "17525370;18056528;21183079;21750661;24129315;34428180;36288343;36424916", "class_list": "", "function": "May regulate basal voltage-dependent L-type Ca(2+) currents and be required for beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916). May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-dependent L-type Ca(2+) currents (PubMed:17525370). Regulates voltage-gated L-type calcium channel subunit alpha-1C trafficking to the cell membrane (PubMed:17525370). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway (PubMed:18056528). Inhibits phosphorylation and activation of CAMK2D (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005516 calmodulin binding;GO:0005525 GTP binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030315 T-tubule", "go_biological_process": "GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O88667-1", "record_type": "protein", "filter_code": "0000000.0100110.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811M1-1", "uniprot_id": [ { "id": "RHG15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q811M1", "type": "external" } ], "mass": 55339.0, "length": 481, "protein_name": "Rho GTPase-activating protein 15", "gene_name": "Arhgap15", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 15 isoform 1", "refseq_ac": [ { "id": "NP_722542", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722542", "type": "external" } ], "gene_names_uniprotkb": "Arhgap15", "gene_names_refseq": "5830480G12Rik; Arhgap15", "protein_names_uniprotkb": "Rho GTPase-activating protein 15; ArhGAP15; Rho-type GTPase-activating protein 15", "protein_names_refseq": "rho GTPase-activating protein 15 isoform 1; rho GTPase-activating protein 15; rho-type GTPase-activating protein 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:76117); (R-MMU-9013149); (R-MMU-9013423)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "21183079;21297076;21551229;21750661;27713499;34428180", "class_list": "", "function": "ArhGAP15 role in the modulation of Rac1/Rac3 activity in the hippocampal inhibitory neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Arhgap15 is associated with acute lung injury, [RefSeq, PubMed]; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene is a RAC GTPase-activating protein that is regulated through its PH domain and by recruitment to the membrane. The protein accelerates hydrolysis of guanosine triphosphate to guanosine diphosphate to repress Rac activity. Knock-out of Arhgap15 function demonstrates that this gene is required to regulate multiple functions in macrophages and neutrophils. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]., [RefSeq]; These results demonstrate the relevance of ArhGAP15 in the selective regulation of multiple neutrophil functions, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9M8;Q3TCU0;Q8C0I5;Q8JZY0", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0008360 regulation of cell shape;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q811M1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BYW1-1", "uniprot_id": [ { "id": "RHG25_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BYW1", "type": "external" } ], "mass": 73383.0, "length": 648, "protein_name": "Rho GTPase-activating protein 25", "gene_name": "Arhgap25", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 25 isoform a", "refseq_ac": [ { "id": "NP_001032816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032816", "type": "external" } ], "gene_names_uniprotkb": "Arhgap25; Kiaa0053", "gene_names_refseq": "A130039I20Rik; Arhgap25", "protein_names_uniprotkb": "Rho GTPase-activating protein 25; Rho-type GTPase-activating protein 25", "protein_names_refseq": "rho GTPase-activating protein 25 isoform a; rho GTPase-activating protein 25; rho-type GTPase-activating protein 25", "tax_id": 10090, "disease": "", "pathway": " (mmu:232201); (R-MMU-9013149)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "19144319;20173027;21183079;27365422;27566826;32434881;34428180;36190314;37234175", "class_list": "", "function": "Arhgap25 Deficiency Leads to Decreased Numbers of Peripheral Blood B Cells and Defective Germinal Center Reactions. Publication Status: Online-Only, [RefSeq, PubMed]; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state., [UniProtKB]; Lacking ARHGAP25 mitigates the symptoms of autoantibody-induced arthritis in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Using Arhgap25-deficient mice, it identified ARHGAP25 as a relevant negative regulator of leukocyte transendothelial migration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RS69;Q2VPR2;Q3TE04;Q3TVX0;Q3UVB7;Q6A0E0;Q8BX98", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0001891 phagocytic cup", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0051058 negative regulation of small GTPase mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BYW1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99P87-1", "uniprot_id": [ { "id": "RETN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99P87", "type": "external" } ], "mass": 12492.0, "length": 114, "protein_name": "Resistin", "gene_name": "Retn", "organism": "Mouse", "refseq_name": "resistin precursor", "refseq_ac": [ { "id": "NP_001191888", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191888", "type": "external" } ], "gene_names_uniprotkb": "Retn; Fizz3", "gene_names_refseq": "ADSF; Fizz3; Retn; Rstn; Xcp4", "protein_names_uniprotkb": "Resistin; ADSF; Adipose tissue-specific secretory factor; Adipose-specific cysteine-rich secreted protein A12-alpha; Cysteine-rich secreted protein FIZZ3", "protein_names_refseq": "adipose tissue-specific secretory factor; adipose-specific cysteine-rich secreted protein A12-alpha; cysteine-rich secreted protein FIZZ3; dominant inhibitory adipocyte-specific secretory factor; found in inflammatory zone 3; resistin precursor", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); COVID-19 (Disease Ontology:DOID:0080600); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); heart disease (Disease Ontology:DOID:114); pyelonephritis (Disease Ontology:DOID:11400); gestational diabetes (Disease Ontology:DOID:11714); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); uremia (Disease Ontology:DOID:4676); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); end stage renal disease (Disease Ontology:DOID:783); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:57264); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11201732;11358969;15155948;30084848;30779550;34324657;34428180;36356648", "class_list": "", "function": "Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes., [UniProtKB, PubMed]; Resistin deletion protects against heart failure injury by targeting DNA damage response., [RefSeq, PubMed]; Resistin impairs mitochondrial homeostasis via cyclase-associated protein 1-mediated fission, leading to obesity-induced metabolic diseases., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:2000252 negative regulation of feeding behavior;GO:0048661 positive regulation of smooth muscle cell proliferation;GO:0032868 response to insulin;GO:0045444 fat cell differentiation;GO:0010714 positive regulation of collagen metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99P87-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERI2-1", "uniprot_id": [ { "id": "RB27A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERI2", "type": "external" } ], "mass": 25017.0, "length": 221, "protein_name": "Ras-related protein Rab-27A", "gene_name": "Rab27a", "organism": "Mouse", "refseq_name": "ras-related protein Rab-27A", "refseq_ac": [ { "id": "NP_001288159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288159", "type": "external" } ], "gene_names_uniprotkb": "Rab27a", "gene_names_refseq": "2210402C08Rik; 2410003M20Rik; 4933437C11Rik; Rab27a; ash", "protein_names_uniprotkb": "Ras-related protein Rab-27A; 3.6.5.2", "protein_names_refseq": "ashen; ras-related protein Rab-27A", "tax_id": 10090, "disease": "hemophagocytic lymphohistiocytosis (Disease Ontology:DOID:0050120); Hermansky-Pudlak syndrome 1 (Disease Ontology:DOID:0060539); Griscelli syndrome type 2 (Disease Ontology:DOID:0060833); platelet storage pool deficiency (Disease Ontology:DOID:2223); non-Langerhans-cell histiocytosis (Disease Ontology:DOID:4330)", "pathway": " (mmu:11891); (R-MMU-6798695); (R-MMU-8873719); (R-MMU-8876198); (R-MMU-9824585)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "10859366;11773082;11887186;12051743;12122117;12578829;16716193;17090228;18266782;18354201;18940603;31219806;34203471;38696123;39927985", "class_list": "", "function": "Rab27a and JFC1/Slp1 permit myeloperoxidase release into the surrounding milieu and constitute key components of the secretory machinery of azurophilic granules in granulocytes, [RefSeq, PubMed]; Rab27b is functionally redundant with Rab27a and the pathogenesis of Griscelli syndrome is determined by the relative expression of Rab27a and Rab27b in specialized cell types. Erratum:[J Clin Invest 2002 Oct;110(8):1213], [RefSeq, PubMed]; The protein encoded by this gene is a member of the Rab family of proteins, which is the largest family within the Ras superfamily of GTPases. This gene product is thought to regulate vesicular transport, together with its specific effectors. Mutations in this gene cause several defects, including actin-based melanosome transport defects and immunodeficiency. Mutations in the human ortholog of this gene are associated with Griscelli syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]., [RefSeq]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB27A regulates homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "1.4.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.22", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019904 protein domain specific binding;GO:0046872 metal ion binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0030141 secretory granule;GO:0030425 dendrite;GO:0005764 lysosome;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0071985 multivesicular body sorting pathway;GO:0051875 pigment granule localization;GO:1990182 exosomal secretion;GO:1903307 positive regulation of regulated secretory pathway;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9ERI2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8QZY4-1", "uniprot_id": [ { "id": "RTBDN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8QZY4", "type": "external" } ], "mass": 26559.0, "length": 247, "protein_name": "Retbindin", "gene_name": "Rtbdn", "organism": "Mouse", "refseq_name": "retbindin precursor", "refseq_ac": [ { "id": "NP_659178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659178", "type": "external" } ], "gene_names_uniprotkb": "Rtbdn", "gene_names_refseq": "A330096I21Rik; Rtbdn; Rtbnd", "protein_names_uniprotkb": "Retbindin", "protein_names_refseq": "retbindin precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:234542)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25542898;26427470;29079576;33526685;34228964", "class_list": "", "function": "Absence of retbindin blocks glycolytic flux, disrupts metabolic homeostasis, and leads to photoreceptor degeneration., [RefSeq, PubMed]; Data suggest Retbindin as a possible flavin binding protein in the neural retina., [RefSeq, PubMed]; Retbindin ablation causes a retinal phenotype characterized by time- and dose-dependent declines in rod and cone photoreceptor functions as early as 120 days of age. Whereas minor retinal ultrastructural defects were observed at all ages examined, a significant decline occurred in photoreceptor nuclei at 240 days of age ( approximately 36.8% rods and approximately 19.9% cones)., [RefSeq, PubMed]; Retbindin is an excellent candidate for binding retinal flavins and possibly participating in their transport from the extracellular space to the photoreceptors., [RefSeq, PubMed]; Retbindin mediates light-damage in mouse retina while its absence leads to premature retinal aging., [RefSeq, PubMed]; Riboflavin-binding protein which might have a role in retinal flavin transport., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6T898", "ec_number_list": [], "go_molecular_function": "GO:0032217 riboflavin transmembrane transporter activity;GO:1902444 riboflavin binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0033165 interphotoreceptor matrix;GO:0009897 external side of plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8QZY4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08576-1", "uniprot_id": [ { "id": "RUN3A_MOUSE", "url": "https://www.uniprot.org/uniprot/O08576", "type": "external" } ], "mass": 50018.0, "length": 446, "protein_name": "RUN domain-containing protein 3A", "gene_name": "Rundc3a", "organism": "Mouse", "refseq_name": "RUN domain-containing protein 3A isoform 2", "refseq_ac": [ { "id": "NP_001239276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239276", "type": "external" } ], "gene_names_uniprotkb": "Rundc3a; Rap2ip; Rpip8", "gene_names_refseq": "RPIP-8; Rap2ip; Rpip8; Rundc3a", "protein_names_uniprotkb": "RUN domain-containing protein 3A; RPIP-8; Rap2-interacting protein 8", "protein_names_refseq": "RUN domain-containing protein 3A isoform 2; RUN domain-containing protein 3A; Rap2 interacting protein 8; rap2-interacting protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:51799)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;15752761;21183079;34203471;9523700", "class_list": "", "function": "May act as an effector of RAP2A in neuronal cells., [UniProtKB, PubMed]; These results suggest that PARG1 is a putative specific effector of Rap2 to regulate Rho., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2A693;A2A694;Q80Y95", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0046068 cGMP metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O08576-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P1Y1-1", "uniprot_id": [ { "id": "RTL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P1Y1", "type": "external" } ], "mass": 61382.0, "length": 553, "protein_name": "Retrotransposon Gag-like protein 3", "gene_name": "Rtl3", "organism": "Mouse", "refseq_name": "retrotransposon Gag-like protein 3", "refseq_ac": [ { "id": "NP_955762", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955762", "type": "external" } ], "gene_names_uniprotkb": "Rtl3; MArt3; Mar3; Zcchc5", "gene_names_refseq": "D430021I08Rik; Gm375; Mar3; Mart3; Rtl3; ZHC5; Zcchc5", "protein_names_uniprotkb": "Retrotransposon Gag-like protein 3; Zinc finger CCHC domain-containing protein 5", "protein_names_refseq": "retrotransposon Gag-like protein 3; zinc finger CCHC domain-containing protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:213436)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16093683;16155747;24129315;27446912", "class_list": "", "function": "May function as a transcriptional regulator (Probable). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (PubMed:27446912)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6P1Y1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YL2-1", "uniprot_id": [ { "id": "RN126_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YL2", "type": "external" } ], "mass": 34081.0, "length": 313, "protein_name": "E3 ubiquitin-protein ligase RNF126", "gene_name": "Rnf126", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF126", "refseq_ac": [ { "id": "NP_653111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653111", "type": "external" } ], "gene_names_uniprotkb": "Rnf126", "gene_names_refseq": "2610010O19Rik; Rnf126", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF126; 2.3.2.27; RING finger protein 126", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF126", "tax_id": 10090, "disease": "", "pathway": " (mmu:70294); (R-MMU-983168)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;23277564;23418353;36563124;37828378", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins (By similarity). Depending on the associated E2 ligase, mediates 'Lys-27'-, 'Lys-29'-, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates (PubMed:23418353). Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome (By similarity). Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome (By similarity). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (By similarity). May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination (PubMed:23418353). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (By similarity). May monoubiquitinate AICDA (By similarity). Acts as a regulator of DNA repair by mediating 'Lys-27'- and 'Lys-29'-linked polyubiquitination of MRE11, thereby promoting the exonuclease activity of MRE11 (By similarity)., [UniProtKB, PubMed, UniProtKB]; RNF126-Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple-Negative Breast Cancer to Radiotherapy. Erratum:[Adv Sci (Weinh). 2025 Mar;12(9):e2417701. doi: 10.1002/advs.202417701. PMID: 39888281], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005154 epidermal growth factor receptor binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0042147 retrograde transport, endosome to Golgi;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91YL2-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99P72-2", "uniprot_id": [ { "id": "RTN4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99P72", "type": "external" } ], "mass": 126613.0, "length": 1162, "protein_name": "Reticulon-4", "gene_name": "Rtn4", "organism": "Mouse", "refseq_name": "reticulon-4 isoform C", "refseq_ac": [ { "id": "NP_077188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077188", "type": "external" } ], "gene_names_uniprotkb": "Rtn4; Kiaa0886; Nogo", "gene_names_refseq": "1110020G17Rik; ASY; C130026I10Rik; NOGO; NSP-CL; NgA; Nogo-A; Nogo-B; Nogo-C; Rtn4; mKIAA0886; mKIAA4153", "protein_names_uniprotkb": "Reticulon-4; Neurite outgrowth inhibitor; Nogo protein", "protein_names_refseq": "neurite outgrowth inhibitor; reticulon-4 isoform C", "tax_id": 10090, "disease": "hereditary spastic paraplegia 12 (Disease Ontology:DOID:0110765); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:68585); (R-MMU-193634)", "pathway_count": 2, "publication_count": 39, "publication_id_list": "10.1101/2023.09.13.557529;12067236;12225863;12488097;15034570;15345747;16452087;17114649;17242355;19131326;19144319;19805174;20093372;20573699;21183079;21183689;22517741;22872234;23299899;23625008;25428506;25917084;26174362;26301690;27763637;27786289;30084848;31219806;32075961;32848054;34203471;34428180;34678516;35771867;37453647;37507081;39426966;40021952;40885482", "class_list": "", "function": "An unexpected role of neurite outgrowth inhibitor A as regulator of tooth enamel formation. Erratum:[Int J Oral Sci. 2024 Nov 8;16(1):64. doi: 10.1038/s41368-024-00330-y. PMID: 39511159] Publication Status: Online-Only, [RefSeq, PubMed]; Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system (PubMed:20573699). Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (By similarity). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (PubMed:20573699). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (PubMed:23625008)., [UniProtKB, UniProtKB, PubMed, PubMed]; Expression by growing axons in the developing nervous system, [RefSeq, PubMed]; Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells (PubMed:15034570). Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P) (PubMed:26301690). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair (PubMed:19805174). Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation (PubMed:21183689). Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes (PubMed:25917084). Also involved in immune response to LPS (PubMed:26174362). Plays a role in liver regeneration through the modulation of hepatocytes proliferation (PubMed:23299899). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Regulates cardiomyocyte apoptosis upon hypoxic conditions (PubMed:27763637). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (By similarity)., [UniProtKB, UniProtKB, PubMed]; Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules. They regulate membrane morphogenesis in the ER by promoting tubular ER production. They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins. However each isoform have specific functions mainly depending on their tissue expression specificities., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTK9;Q78NS1;Q7TNB7;Q80W95;Q8BGK7;Q8BGM9;Q8BH78;Q8BHF5;Q8K290;Q8K3G7;Q8K3G8;Q9CTE3", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0045296 cadherin binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:2000347 positive regulation of hepatocyte proliferation;GO:0045687 positive regulation of glial cell differentiation;GO:1905523 positive regulation of macrophage migration;GO:0071786 endoplasmic reticulum tubular network organization;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 5.3, "record_id": "Q99P72-2", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJS0-1", "uniprot_id": [ { "id": "SCUB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJS0", "type": "external" } ], "mass": 109924.0, "length": 997, "protein_name": "Signal peptide, CUB and EGF-like domain-containing protein 2", "gene_name": "Scube2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Scube2; Cegp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Signal peptide, CUB and EGF-like domain-containing protein 2; Protein CEGP1; Scube/You", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:56788); (R-MMU-5362798)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11287194;11528127;21750661;22677548;22902404;24522195;25428506;26875496;27834687;33038332", "class_list": "", "function": "Lipid-binding protein carrier required for sonic hedgehog (SHH) long-range signaling: binds to the dually lipid-modified Sonic hedgehog protein N-product (ShhN) and promotes its release from producing cells, allowing it to act as a morphogen for distant signaling (PubMed:22677548, PubMed:22902404, PubMed:33038332). ShhN is then transferred to the CDON-BOC heterodimer and GAS1 coreceptors to reach its target, the patched receptor (PTCH1 or PTCH2), followed by activation of the smoothened signaling pathway (PubMed:33038332). May also enhance the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to increase SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097108 hedgehog family protein binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0019897 extrinsic component of plasma membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0007165 signal transduction;GO:0045669 positive regulation of osteoblast differentiation;GO:1902732 positive regulation of chondrocyte proliferation;GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9JJS0-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46062-1", "uniprot_id": [ { "id": "SIPA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P46062", "type": "external" } ], "mass": 112066.0, "length": 1037, "protein_name": "Signal-induced proliferation-associated protein 1", "gene_name": "Sipa1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sipa1; Spa-1; Spa1", "gene_names_refseq": "", "protein_names_uniprotkb": "Signal-induced proliferation-associated protein 1; GTPase-activating protein Spa-1; Sipa-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "chronic myeloid leukemia (Disease Ontology:DOID:8552)", "pathway": " (mmu:20469); (R-MMU-392517)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "18081427;19144319;21183079;21750661;28135057;31219806;34887587;39627609;7799964;9027487;9346962", "class_list": "", "function": "GTPase activator for the nuclear Ras-related regulatory proteins Rap1, Rsr1 and Ran in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P70204", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm;GO:0012505 endomembrane system;GO:0032991 protein-containing complex", "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:0042631 cellular response to water deprivation;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P46062-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFZ5-1", "uniprot_id": [ { "id": "S22AC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CFZ5", "type": "external" } ], "mass": 60194.0, "length": 553, "protein_name": "Solute carrier family 22 member 12", "gene_name": "Slc22a12", "organism": "Mouse", "refseq_name": "solute carrier family 22 member 12", "refseq_ac": [ { "id": "NP_033229", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033229", "type": "external" } ], "gene_names_uniprotkb": "Slc22a12; Urat1", "gene_names_refseq": "OAT4L; Rst; Slc22a12; Slc22al2; URAT1", "protein_names_uniprotkb": "Solute carrier family 22 member 12; RST; Renal-specific transporter; URAT1; Urate anion exchanger 1; Urate:anion antiporter SLC22A12", "protein_names_refseq": "renal-specific transporter; solute carrier family 22 (organic cation transporter)-like 2; solute carrier family 22 member 12; urate anion exchanger 1; urate:anion antiporter SLC22A12", "tax_id": 10090, "disease": "diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (mmu:20521); (R-MMU-561048)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14747372;15284287;21183079;21750661;31882426;34863940;9409754", "class_list": "", "function": "Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions (PubMed:14747372). Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid (PubMed:14747372). Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-) (PubMed:14747372). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate (By similarity). Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption. Orotate transport is Cl(-)-dependent (By similarity)., [UniProtKB, UniProtKB, PubMed]; Extracellular uric acid levels in the proximal tubule epithelial cells positively regulated URAT1 expression.Renal URAT1 expression increased in hyperuricemic mice., [RefSeq, PubMed]; Mouse RST mediates the efflux of organic anions including urate and works as exit for organic anions in the proximal tubules, [RefSeq, PubMed]; URAT1-selective inhibition ameliorates insulin resistance by attenuating diet-induced hepatic steatosis and brown adipose tissue whitening in mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O54778", "ec_number_list": [], "go_molecular_function": "GO:0030165 PDZ domain binding;GO:0015143 urate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0046415 urate metabolic process;GO:0015711 organic anion transport;GO:0009410 response to xenobiotic stimulus;GO:0015747 urate transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8CFZ5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIS8-1", "uniprot_id": [ { "id": "S12A4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIS8", "type": "external" } ], "mass": 120624.0, "length": 1085, "protein_name": "Solute carrier family 12 member 4", "gene_name": "Slc12a4", "organism": "Mouse", "refseq_name": "solute carrier family 12 member 4 isoform 2", "refseq_ac": [ { "id": "NP_033221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033221", "type": "external" } ], "gene_names_uniprotkb": "Slc12a4; Kcc1", "gene_names_refseq": "KCC1; RBCKCC1; Slc12a4", "protein_names_uniprotkb": "Solute carrier family 12 member 4; Electroneutral potassium-chloride cotransporter 1; Erythroid K-Cl cotransporter 1; mKCC1", "protein_names_refseq": "K-Cl Co-transporter-1; K-Cl cotransporter KCC1; electroneutral potassium-chloride cotransporter 1; erythroid K-Cl cotransporter 1; mKCC1; solute carrier family 12 member 4 isoform 2", "tax_id": 10090, "disease": "epilepsy (Disease Ontology:DOID:1826); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:20498); (R-MMU-426117)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10564083;11004507;11551954;17242355;19144319;19349973;19656770;21183079;21750661;25428506;30084848;30779550;31219806;31352162;31835175;35820727;9516379", "class_list": "", "function": "Effect of genetic inactivation of KCC3 and KCC1 in the SAD mouse model of sickle red cell dehydration, finding decreased red cell density and improved hematological indices. Erratum:[Blood Cells Mol Dis. 2020 Mar;81:102390. doi: 10.1016/j.bcmd.2019.102390. PMID: 31931456], [RefSeq, PubMed]; Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10564083, PubMed:11551954). May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (Probable)., [UniProtKB, PubMed, PubMed]; The effect of genetic inactivation of K-Cl cotransporters KCC1 and KCC3 in a mouse model of beta-thalassemia intermedia; conclude that genetic inactivation of K-Cl cotransport can reverse red cell dehydration and partially attenuate the hematologic phenotype in a mouse model of beta-thalassemia., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O55069;Q9ET57", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0015379 potassium:chloride symporter activity;GO:0120283 protein serine/threonine kinase binding;GO:0046873 metal ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0006884 cell volume homeostasis;GO:1902476 chloride transmembrane transport;GO:0055075 potassium ion homeostasis;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9JIS8-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08530-1", "uniprot_id": [ { "id": "S1PR1_MOUSE", "url": "https://www.uniprot.org/uniprot/O08530", "type": "external" } ], "mass": 42639.0, "length": 382, "protein_name": "Sphingosine 1-phosphate receptor 1", "gene_name": "S1pr1", "organism": "Mouse", "refseq_name": "sphingosine 1-phosphate receptor 1", "refseq_ac": [ { "id": "NP_031927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031927", "type": "external" } ], "gene_names_uniprotkb": "S1pr1; Edg1; Lpb1", "gene_names_refseq": "Edg1; Lpb1; S1p1; S1pr1; S1p", "protein_names_uniprotkb": "Sphingosine 1-phosphate receptor 1; Endothelial differentiation G protein-coupled receptor 1; Lysophospholipid receptor B1; S1P receptor 1; S1P receptor Edg-1; S1P1; Sphingosine 1-phosphate receptor Edg-1", "protein_names_refseq": "S1P receptor 1; S1P receptor Edg-1; endothelial differentiation G-protein coupled receptor 1; endothelial differentiation sphingolipid G-protein-coupled receptor 1; lysophospholipid receptor B1; sphingosine 1-phosphate receptor 1; sphingosine 1-phosphate receptor Edg-1", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763)", "pathway": " (mmu:13609); (R-MMU-419408)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;11032855;11230698;11726541;12869509;14732704;14737169;16314531;17242355;19204730;19286607;21183079;21668976;22951644;23806337;24076635;34428180;9226368;9931453", "class_list": "", "function": "G protein-coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a G-protein-coupled receptor bound by the lysophospholipid, sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. This receptor is highly expressed in T and B lymphocytes, and it plays a role in T cell and B cell export from peripheral lymphoid organs. This protein is bound and downregulated by FTY720, an exogenous immunosuppressant drug studied in mouse disease models for multiple sclerosis in humans. [provided by RefSeq, Jan 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9DC35;Q9R235", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0001664 G protein-coupled receptor binding;GO:0038036 sphingosine-1-phosphate receptor activity;GO:0046625 sphingolipid binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0045124 regulation of bone resorption;GO:0003376 sphingosine-1-phosphate receptor signaling pathway;GO:0001525 angiogenesis;GO:0006935 chemotaxis;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "O08530-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16014-1", "uniprot_id": [ { "id": "SCG1_MOUSE", "url": "https://www.uniprot.org/uniprot/P16014", "type": "external" } ], "mass": 77969.0, "length": 677, "protein_name": "Secretogranin-1", "gene_name": "Chgb", "organism": "Mouse", "refseq_name": "secretogranin-1 precursor", "refseq_ac": [ { "id": "NP_031720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031720", "type": "external" } ], "gene_names_uniprotkb": "Chgb; Scg-1; Scg1", "gene_names_refseq": "Chgb; Scg-1; cgB; sgI", "protein_names_uniprotkb": "Secretogranin-1; CgB; Chromogranin-B; Secretogranin I; SgI", "protein_names_refseq": "secretogranin I; secretogranin-1 precursor; secretogranin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:12653); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21183079;22872234;2320426;2335203;30084848;34203471;9422384", "class_list": "", "function": "Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P16014-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61327-1", "uniprot_id": [ { "id": "SC6A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61327", "type": "external" } ], "mass": 68805.0, "length": 619, "protein_name": "Sodium-dependent dopamine transporter", "gene_name": "Slc6a3", "organism": "Mouse", "refseq_name": "sodium-dependent dopamine transporter", "refseq_ac": [ { "id": "NP_034150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034150", "type": "external" } ], "gene_names_uniprotkb": "Slc6a3; Dat1; Dat", "gene_names_refseq": "DAT; Dat1; Slc6a3", "protein_names_uniprotkb": "Sodium-dependent dopamine transporter; DA transporter; DAT; Solute carrier family 6 member 3", "protein_names_refseq": "DA transporter; dopamine transporter 1; sodium-dependent dopamine transporter", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); autism spectrum disorder (Disease Ontology:DOID:0060041); classic dopamine transporter deficiency syndrome (Disease Ontology:DOID:0070489); mild cognitive impairment (Disease Ontology:DOID:0080832); Parkinsonism (Disease Ontology:DOID:0080855); dopamine beta-hydroxylase deficiency (Disease Ontology:DOID:0090145); hypertension (Disease Ontology:DOID:10763); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); hyperprolactinemia (Disease Ontology:DOID:12700); high grade glioma (Disease Ontology:DOID:3070); schizophrenia (Disease Ontology:DOID:5419); amphetamine abuse (Disease Ontology:DOID:670); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:13162); (R-MMU-379397); (R-MMU-379398); (R-MMU-379401); (R-MMU-442660)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "10375632;12177201;12606774;17296554;19357284;28072417;30936473;33300544;7637582", "class_list": "", "function": "Mediates sodium- and chloride-dependent transport of dopamine (PubMed:10375632, PubMed:12606774). Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (PubMed:30936473)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 15, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q60719;Q9R1I2", "ec_number_list": [], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0005334 norepinephrine:sodium symporter activity;GO:0002020 protease binding;GO:0005102 signaling receptor binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0043679 axon terminus", "go_biological_process": "GO:0021984 adenohypophysis development;GO:0015844 monoamine transport;GO:1990384 hyaloid vascular plexus regression;GO:0007626 locomotory behavior;GO:0035094 response to nicotine", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q61327-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99J08-1", "uniprot_id": [ { "id": "S14L2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99J08", "type": "external" } ], "mass": 46300.0, "length": 403, "protein_name": "SEC14-like protein 2", "gene_name": "Sec14l2", "organism": "Mouse", "refseq_name": "SEC14-like protein 2", "refseq_ac": [ { "id": "NP_653103", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653103", "type": "external" } ], "gene_names_uniprotkb": "Sec14l2", "gene_names_refseq": "1300013M05Rik; Sec14l2; Spf; TAP", "protein_names_uniprotkb": "SEC14-like protein 2; Alpha-tocopherol-associated protein; TAP", "protein_names_refseq": "SEC14-like 2; SEC14-like protein 2; alpha-tocopherol-associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67815)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23806337;34428180;37453647", "class_list": "", "function": "Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0008289 lipid binding;GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045542 positive regulation of cholesterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99J08-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQG3-1", "uniprot_id": [ { "id": "SCEL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQG3", "type": "external" } ], "mass": 72972.0, "length": 652, "protein_name": "Sciellin", "gene_name": "Scel", "organism": "Mouse", "refseq_name": "sciellin", "refseq_ac": [ { "id": "NP_075024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075024", "type": "external" } ], "gene_names_uniprotkb": "Scel", "gene_names_refseq": "9230114I02Rik; Scel", "protein_names_uniprotkb": "Sciellin", "protein_names_refseq": "sciellin", "tax_id": 10090, "disease": "", "pathway": " (mmu:64929)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11112355;16028229;21183079;23806337;34428180", "class_list": "", "function": "May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope (By similarity)., [UniProtKB]; We conclude that sciellin null mice had no structural anomalies and the transgenic mice did not act as a dominant-negative mutation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CTT9", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0008544 epidermis development;GO:0030216 keratinocyte differentiation;GO:0009612 response to mechanical stimulus;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9EQG3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NS82-1", "uniprot_id": [ { "id": "RETR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NS82", "type": "external" } ], "mass": 57542.0, "length": 541, "protein_name": "Reticulophagy regulator 2", "gene_name": "Retreg2", "organism": "Mouse", "refseq_name": "reticulophagy regulator 2 isoform 2", "refseq_ac": [ { "id": "NP_001292160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292160", "type": "external" } ], "gene_names_uniprotkb": "Retreg2; Fam134a", "gene_names_refseq": "Fam134a; Retreg2", "protein_names_uniprotkb": "Reticulophagy regulator 2", "protein_names_refseq": "family with sequence similarity 134, member A; protein FAM134A; reticulophagy regulator 2 isoform 2; reticulophagy regulator 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:227298)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15345747;17242355;19144319;19838196;21183079;21750661;31599954;34338405;34428180", "class_list": "", "function": "Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (PubMed:34338405)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TA48;Q3TMF7;Q8BSD3;Q8CHY1;Q8R0Q3", "ec_number_list": [], "go_molecular_function": "GO:0140506 endoplasmic reticulum-autophagosome adaptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030574 collagen catabolic process;GO:0061709 reticulophagy;GO:0007029 endoplasmic reticulum organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6NS82-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6M7-1", "uniprot_id": [ { "id": "SPCS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P6M7", "type": "external" } ], "mass": 55326.0, "length": 504, "protein_name": "O-phosphoseryl-tRNA(Sec) selenium transferase", "gene_name": "Sepsecs", "organism": "Mouse", "refseq_name": "O-phosphoseryl-tRNA(Sec) selenium transferase isoform 1", "refseq_ac": [ { "id": "NP_766078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766078", "type": "external" } ], "gene_names_uniprotkb": "Sepsecs; D5Ertd135e", "gene_names_refseq": "D5Ertd135e; SLA; SecS; Sepsecs", "protein_names_uniprotkb": "O-phosphoseryl-tRNA(Sec) selenium transferase; 2.9.1.2; SLA; Sec synthase; Selenocysteine synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep-tRNA:Sec-tRNA synthase; SepSecS; Soluble liver antigen homolog; UGA suppressor tRNA-associated protein", "protein_names_refseq": "O-phosphoseryl-tRNA(Sec) selenium transferase isoform 1; O-phosphoseryl-tRNA(Sec) selenium transferase; UGA suppressor tRNA-associated protein; selenocysteinyl-tRNA(Sec) synthase; soluble liver antigen homolog", "tax_id": 10090, "disease": "pontocerebellar hypoplasia type 2D (Disease Ontology:DOID:0060270)", "pathway": " (mmu:211006)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16230358;17194211;18093968;21750661;25428506;27802388;30084848;31219806;33300544;34428180", "class_list": "", "function": "Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; SECp43 and SLA have roles in selenoprotein synthesis [soluble liver antigen], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZS6", "ec_number_list": [ { "id": "2.9.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.9.1.2", "type": "external" } ], "go_molecular_function": "GO:0000049 tRNA binding;GO:0098621 O-phosphoseryl-tRNA(Sec) selenium transferase activity", "go_cellular_component": "GO:1990234 transferase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0001514 selenocysteine incorporation;GO:0001717 conversion of seryl-tRNAsec to selenocys-tRNAsec;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6P6M7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JM13-1", "uniprot_id": [ { "id": "RABX5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JM13", "type": "external" } ], "mass": 56869.0, "length": 491, "protein_name": "Rab5 GDP/GTP exchange factor", "gene_name": "Rabgef1", "organism": "Mouse", "refseq_name": "rab5 GDP/GTP exchange factor isoform a", "refseq_ac": [ { "id": "NP_001185988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185988", "type": "external" } ], "gene_names_uniprotkb": "Rabgef1; Rabex5", "gene_names_refseq": "Rab5ef; Rabex5; Rabgef1; Rin2", "protein_names_uniprotkb": "Rab5 GDP/GTP exchange factor; Rabex-5", "protein_names_refseq": "Rab5 exchange factor; Ras negative regulator Rabex-5/Rin2; rab5 GDP/GTP exchange factor isoform a; rab5 GDP/GTP exchange factor; rabex-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:56715); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10926822;21183079;21750661;25428506;25605945;27820702;28135057;30084848;31599954;31628426;33362196;34428180;38377943", "class_list": "", "function": "Acts as a guanine-nucleotide releasing factor (GEF) for RAB5A by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP (By similarity). Forms a complex with RABEP1 that acts as Rab4/Rab5 effector regulating endosome fusion. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes (By similarity). Also functions as a ubiquitin ligase (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Epithelial RABGEF1 deficiency promotes intestinal inflammation by dysregulating intrinsic MYD88-dependent innate signaling., [RefSeq, PubMed]; Findings reveal a key role for RABGEF1 in dampening keratinocyte-intrinsic MYD88 signaling and sustaining epidermal barrier function, [RefSeq, PubMed]; Guanine nucleotide exchange factor RABGEF1 facilitates TNF-induced necroptosis by targeting cIAP1., [RefSeq, PubMed]; Loss of endocytosis-associated RabGEF1 causes aberrant morphogenesis and altered autophagy in photoreceptors leading to retinal degeneration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UIW0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0061630 ubiquitin protein ligase activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005769 early endosome;GO:0005829 cytosol;GO:0030425 dendrite;GO:0055037 recycling endosome", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway;GO:0006897 endocytosis;GO:0015031 protein transport;GO:0001933 negative regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9JM13-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48453-1", "uniprot_id": [ { "id": "PP2BB_MOUSE", "url": "https://www.uniprot.org/uniprot/P48453", "type": "external" } ], "mass": 59173.0, "length": 525, "protein_name": "Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform", "gene_name": "Ppp3cb", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform 2", "refseq_ac": [ { "id": "NP_001297355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297355", "type": "external" } ], "gene_names_uniprotkb": "Ppp3cb; Calnb", "gene_names_refseq": "1110063J16Rik; Calnb; CnAbeta; Cnab; Ppp3cb", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; 3.1.3.16; CAM-PRP catalytic subunit; CNA beta; Calmodulin-dependent calcineurin A subunit beta isoform", "protein_names_refseq": "CAM-PRP catalytic subunit; CNA beta; PP2BA beta; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform 2", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); aortic valve stenosis (Disease Ontology:DOID:1712); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:19056); (R-MMU-2025928); (R-MMU-2871809); (R-MMU-4086398); (R-MMU-5607763)", "pathway_count": 5, "publication_count": 19, "publication_id_list": "10200317;12773574;1328240;15509543;1659808;21183079;21435446;21750661;25428506;25967121;26029823;26495903;30084848;30779550;31696965;34228904;34428180;35247520;38420800", "class_list": "", "function": "Calcineurin (PPP3CB) regulates angiotensin II-dependent vascular remodelling by potentiating EGFR signalling in mice., [RefSeq, PubMed]; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (By similarity). Dephosphorylates TFEB in response to lysosomal Ca(2+) release, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis (By similarity). Dephosphorylates and activates transcription factor NFATC1 (By similarity). Dephosphorylates and inactivates transcription factor ELK1 (By similarity). Dephosphorylates DARPP32 (By similarity). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (PubMed:26029823). May play a role in skeletal muscle fiber type specification (PubMed:12773574)., [UniProtKB, UniProtKB, PubMed, PubMed]; Coexpression of calcineurin A and B subunits in various subcellular and synaptic compartments of cerebellar neurons and glia with particular abundance at parallel fiber-Purkinje cell synapses., [RefSeq, PubMed]; PPP3CB Inhibits Cell Proliferation and the Warburg Effect in Bladder Cancer by Blocking PDHK1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NZR4", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0033192 calmodulin-dependent protein phosphatase activity;GO:0005516 calmodulin binding;GO:0019899 enzyme binding;GO:0046983 protein dimerization activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:0006468 protein phosphorylation;GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:1900181 negative regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P48453-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62159-1", "uniprot_id": [ { "id": "RHOC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62159", "type": "external" } ], "mass": 22006.0, "length": 193, "protein_name": "Rho-related GTP-binding protein RhoC", "gene_name": "Rhoc", "organism": "Mouse", "refseq_name": "rho-related GTP-binding protein RhoC", "refseq_ac": [ { "id": "NP_001278788", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278788", "type": "external" } ], "gene_names_uniprotkb": "Rhoc; Arhc", "gene_names_refseq": "Arh9; Arhc; Rhoc", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoC; 3.6.5.2; SIG-61; Silica-induced gene 61 protein", "protein_names_refseq": "SIG-61; aplysia ras-related homolog 9 (RhoC); ras homolog 9 (RhoC); ras homolog gene family, member C; rho-related GTP-binding protein RhoC; silica-induced gene 61 protein", "tax_id": 10090, "disease": "peroxisomal biogenesis disorder (Disease Ontology:DOID:0080377); neurodegenerative disease (Disease Ontology:DOID:1289); breast cancer (Disease Ontology:DOID:1612); ovarian carcinoma (Disease Ontology:DOID:4001); ulcerative colitis (Disease Ontology:DOID:8577)", "pathway": " (mmu:11853); (R-MMU-416482); (R-MMU-416572); (R-MMU-5625740); (R-MMU-5625900); (R-MMU-5627117); (R-MMU-5663220); (R-MMU-9013106)", "pathway_count": 8, "publication_count": 7, "publication_id_list": "20974804;21750661;29113998;33300544;38807216;7868905;8662891", "class_list": "", "function": "Elevated expression of wildtype RhoC promotes ErbB2- and Pik3ca-induced mammary tumor formation. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells., [UniProtKB, PubMed]; What was seen for RhoC, mDia1 silencing through RNAi inhibited phagosome formation. Additionally, the coexpression of mDia1 with constitutively active mutant RhoC-G14V or expression of active mutant mDia1-DeltaN3 drastically inhibited the uptake of IgG-Es. These data suggest that RhoC modulates phagosome formation be modifying actin cytoskeletal remodeling via mDia1, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUN0", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "1.3.1.70", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.70", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032154 cleavage furrow", "go_biological_process": "GO:0043297 apical junction assembly;GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0016477 cell migration;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q62159-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BKR2-1", "uniprot_id": [ { "id": "SL9B2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5BKR2", "type": "external" } ], "mass": 58934.0, "length": 547, "protein_name": "Sodium/hydrogen exchanger 9B2", "gene_name": "Slc9b2", "organism": "Mouse", "refseq_name": "sodium/hydrogen exchanger 9B2 isoform 1", "refseq_ac": [ { "id": "NP_849208", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849208", "type": "external" } ], "gene_names_uniprotkb": "Slc9b2; Nha2; Nhe10; Nhedc2", "gene_names_refseq": "NHA2; NHE10; Nhedc2; Slc9b2; nha-oc; nhaoc", "protein_names_uniprotkb": "Sodium/hydrogen exchanger 9B2; NHA-oc; NHE domain-containing protein 2; Na(+)/H(+) exchanger NHA2; Na(+)/H(+) exchanger-like domain-containing protein 2; Soditlum/hydrogen exchanger-like domain-containing protein 2; Solute carrier family 9 subfamily B member 2", "protein_names_refseq": "NHE domain-containing protein 2; Na(+)/H(+) exchanger-like domain-containing protein 2; Na+/H+ exchanger domain containing 2; mitochondrial Na(+)/H(+) exchanger NHA2; mitochondrial sodium/hydrogen exchanger 9B2; mitochondrial sodium/hydrogen exchanger NHA2; soditlum/hydrogen exchanger-like domain-containing protein 2; sodium/hydrogen exchanger 9B2 isoform 1; sodium/hydrogen exchanger-like domain-containing protein 2; solute carrier family 9 subfamily B member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:97086); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "17698421;17988971;18000046;18269914;18508966;20441802;21750661;22985540;23720317;27010853;27909897;32956652", "class_list": "", "function": "Data suggest that dietary salt elevates NHA2 expression in the nephron; NHA2 expression is localized apically to distal convoluted tubules and connecting tubules in the nephron; NHA2 expression in the nephron partially overlaps in distribution with V-type ATPase., [RefSeq, PubMed]; Electroneutral Na(+) Li(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane (PubMed:17988971, PubMed:18508966). Uses the proton gradient/membrane potential to extrude sodium (By similarity). Contributes to the regulation of intracellular pH and sodium homeostasis (PubMed:27909897). Also able to mediate Na(+)/Li(+) antiporter activity in kidney (By similarity). May play a physiological role in renal tubular function and blood pressure homeostasis (PubMed:27909897, PubMed:32956652). Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (PubMed:23720317). Involved in sperm motility and fertility (PubMed:27010853). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (PubMed:17988971, PubMed:20441802)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; NHA-oc/NHA2 displays the expected activities of a bona fide cation-proton antiporter and plays a key role(s) in normal osteoclast differentiation and function, [RefSeq, PubMed]; Nha-oc is expressed by terminally differentiated osteoclasts., [RefSeq, PubMed]; These data from NHA2-deficient mice suggest that NHA2 is dispensable for osteoclast differentiation and bone resorption both in vitro and in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CA47;Q8CDX4", "ec_number_list": [], "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0010348 lithium:proton antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0031966 mitochondrial membrane;GO:0055037 recycling endosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:2001206 positive regulation of osteoclast development;GO:0030317 flagellated sperm motility;GO:0072583 clathrin-dependent endocytosis;GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q5BKR2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55014-1", "uniprot_id": [ { "id": "S12A1_MOUSE", "url": "https://www.uniprot.org/uniprot/P55014", "type": "external" } ], "mass": 120355.0, "length": 1095, "protein_name": "Solute carrier family 12 member 1", "gene_name": "Slc12a1", "organism": "Mouse", "refseq_name": "solute carrier family 12 member 1 isoform F", "refseq_ac": [ { "id": "NP_001073158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073158", "type": "external" } ], "gene_names_uniprotkb": "Slc12a1; Nkcc2", "gene_names_refseq": "D630042G03Rik; Nkcc2; Slc12a1; mBSC1; mNKCC2; urehr3", "protein_names_uniprotkb": "Solute carrier family 12 member 1; BSC1; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; Kidney-specific Na-K-Cl symporter; Na-K-2Cl cotransporter 2; mNKCC2", "protein_names_refseq": "BSC1; Na-K-2Cl cotransporter 2; bumetanide-sensitive cotransporter type 1; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; kidney-specific Na-K-Cl symporter; solute carrier family 12 member 1 isoform F", "tax_id": 10090, "disease": "Bartter disease type 1 (Disease Ontology:DOID:0110142); epilepsy (Disease Ontology:DOID:1826); Bartter disease (Disease Ontology:DOID:445)", "pathway": " (mmu:20495); (R-MMU-426117)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "10070158;11790783;17341212;19176702;20091762;20385770;21183079;21321328;21750661;21972418;23123217;24808538;25967121;27213818;27681558;29993276;30084848;31219806;31444371;34114742;34203471;34428180;7573490", "class_list": "", "function": "High affinity, high capacity cotransporter for sodium, potassium and chloride ions, with a coupling ratio 1Na(+):1K(+):2Cl(-)., [UniProtKB, PubMed]; High affinity, low capacity cotransporter for sodium, potassium and chloride ions, with a coupling ratio 1Na(+):1K(+):2Cl(-)., [UniProtKB, PubMed]; Low affinity, low capacity cotransporter for sodium, potassium and chloride ions, with a coupling ratio 1Na(+):1K(+):2Cl(-)., [UniProtKB, PubMed]; Renal sodium, potassium and chloride non-electrogenic ion symporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation (Probable) (PubMed:11790783). It can substitute NH4(+) for K(+), enabling NH4(+) apical transmembrane transport in the medullary thick ascending limb (MTAL). This function is crucial for maintaining ammonium homeostasis by the kidney, particularly during metabolic acidosis (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35938;Q91W55;Q9Z1E0", "ec_number_list": [], "go_molecular_function": "GO:0008511 sodium:potassium:chloride symporter activity;GO:0120283 protein serine/threonine kinase binding;GO:7770002 sodium:ammonium:chloride symporter activity", "go_cellular_component": "GO:0009986 cell surface;GO:0070062 extracellular exosome;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0071918 urea transmembrane transport;GO:0097272 ammonium homeostasis;GO:0070634 transepithelial ammonium transport;GO:0001822 kidney development;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P55014-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80V31-1", "uniprot_id": [ { "id": "CE104_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80V31", "type": "external" } ], "mass": 103946.0, "length": 926, "protein_name": "Centrosomal protein of 104 kDa", "gene_name": "Cep104", "organism": "Mouse", "refseq_name": "centrosomal protein of 104 kDa isoform 1", "refseq_ac": [ { "id": "NP_808341", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808341", "type": "external" } ], "gene_names_uniprotkb": "Cep104; Kiaa0562", "gene_names_refseq": "A930027E11; Cep104; Kiaa0562; mKIAA0562", "protein_names_uniprotkb": "Centrosomal protein of 104 kDa; Cep104", "protein_names_refseq": "centrosomal protein of 104 kDa isoform 1; centrosomal protein of 104 kDa; glycine-, glutamate-, thienylcyclohexylpiperidine-binding protein; likely ortholog of H. sapiens glycine-, glutamate-, thienylcyclohexylpiperidine-binding protein", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 77 (Disease Ontology:DOID:0081236); Joubert syndrome 25 (Disease Ontology:DOID:0110994)", "pathway": " (mmu:230967)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;34203471;34428180", "class_list": "", "function": "Required for ciliogenesis and for structural integrity at the ciliary tip., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AX97;Q6ZQ95", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0016594 glycine binding;GO:0016595 glutamate binding;GO:0016596 thienylcyclohexylpiperidine binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005929 cilium;GO:0005814 centriole", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80V31-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69ZH9-1", "uniprot_id": [ { "id": "RHG23_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69ZH9", "type": "external" } ], "mass": 161832.0, "length": 1483, "protein_name": "Rho GTPase-activating protein 23", "gene_name": "Arhgap23", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 23 isoform 2", "refseq_ac": [ { "id": "NP_067468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067468", "type": "external" } ], "gene_names_uniprotkb": "Arhgap23; Kiaa1501; MNCb-1301", "gene_names_refseq": "A330041B18Rik; Arhgap23", "protein_names_uniprotkb": "Rho GTPase-activating protein 23; Rho-type GTPase-activating protein 23", "protein_names_refseq": "rho GTPase-activating protein 23 isoform 2; rho GTPase-activating protein 23; rho-type GTPase-activating protein 23", "tax_id": 10090, "disease": "", "pathway": " (mmu:58996); (R-MMU-8980692); (R-MMU-9013149)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;22517741;31599954;34428180", "class_list": "", "function": "GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNY7;Q9JJD6", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q69ZH9-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWH4-1", "uniprot_id": [ { "id": "RE114_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWH4", "type": "external" } ], "mass": 28211.0, "length": 259, "protein_name": "Meiotic recombination protein REC114", "gene_name": "Rec114", "organism": "Mouse", "refseq_name": "meiotic recombination protein REC114", "refseq_ac": [ { "id": "NP_082874", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082874", "type": "external" } ], "gene_names_uniprotkb": "Rec114", "gene_names_refseq": "2410076I21Rik; 4930527A11Rik; Rec114", "protein_names_uniprotkb": "Meiotic recombination protein REC114", "protein_names_refseq": "meiotic recombination protein REC114", "tax_id": 10090, "disease": "", "pathway": " (mmu:73673)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "20551173;21750661;27723721;30569039;31003867;36396648;37431931;37976262", "class_list": "", "function": "A crystal structure defines a pleckstrin homology (PH) domain in REC114 and its direct intermolecular contacts with ANKRD31. In vivo, ANKRD31 stabilizes REC114 association with the PAR and elsewhere. Our findings inform a model in which ANKRD31 is a scaffold anchoring REC114 and other factors to specific genomic locations, thereby regulating DSB formation., [RefSeq, PubMed]; Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation., [RefSeq, PubMed]; Essential roles of the ANKRD31-REC114 interaction in meiotic recombination and mouse spermatogenesis., [RefSeq, PubMed]; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination (PubMed:20551173, PubMed:27723721, PubMed:30569039, PubMed:36396648). Activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis (PubMed:27723721, PubMed:30569039). Required for both spermatogenesis and oogenesis (PubMed:30569039)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005694 chromosome", "go_biological_process": "GO:0006310 DNA recombination;GO:0007283 spermatogenesis;GO:0048477 oogenesis;GO:0042138 meiotic DNA double-strand break formation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CWH4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09044-1", "uniprot_id": [ { "id": "SNP23_MOUSE", "url": "https://www.uniprot.org/uniprot/O09044", "type": "external" } ], "mass": 23261.0, "length": 210, "protein_name": "Synaptosomal-associated protein 23", "gene_name": "Snap23", "organism": "Mouse", "refseq_name": "synaptosomal-associated protein 23 isoform a", "refseq_ac": [ { "id": "NP_001171263", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171263", "type": "external" } ], "gene_names_uniprotkb": "Snap23; Sndt", "gene_names_refseq": "23kDa; SNAP-23; Snap23; Sndt; Syndet", "protein_names_uniprotkb": "Synaptosomal-associated protein 23; SNAP-23; Syndet; Vesicle-membrane fusion protein SNAP-23", "protein_names_refseq": "synaptosomal-associated protein 23 isoform a; synaptosomal-associated protein, 23kD; vesicle-membrane fusion protein SNAP-23", "tax_id": 10090, "disease": "", "pathway": " (mmu:20619); (R-MMU-1236974); (R-MMU-199992); (R-MMU-6798695); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013149); (R-MMU-9013406); (R-MMU-9013423); (R-MMU-9035034)", "pathway_count": 10, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;10773458;15363411;15611044;17242355;18630941;19144319;21183079;21750661;23613522;26198635;34428180;35816155;38182732;38198890;9067602;9168999;9507000;9886085", "class_list": "", "function": "SNAP-25, but not SNAP-23, is essential for photoreceptor development, survival, and function in mice. Publication Status: Online-Only, [RefSeq, PubMed]; SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) are essential proteins for intracellular membrane fusion. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four-helix bundle whose assembly releases energy that drives membrane fusion. The core SNARE complex typically consists of four alpha-helical domains, three from target membrane SNAREs (t-SNAREs) and one from a vesicle SNARE (v-SNARE) (PubMed:38198890). SNAP23 is a t-SNARE (target-SNARE) that resides on target membrane and functions in the fusion of transport vesicles with the plasma membrane in immune cells. In macrophages, regulates the stimulus-dependent vesicular transport of TLR4 from recycling endosomes to the plasma membrane by cooperating with STX11 and thereby plays a critical role in the recognition of microbial components and the induction of innate and adaptive immunity (By similarity). In skeletal muscle satellite cells, SNAP23 cooperates with its cognate SNAREs VAMP4 and STX11 to facilitate CD36 vesicular transport from endosomes to the plasma membrane, an essential step in muscle regeneration (PubMed:38198890)., [UniProtKB, UniProtKB, PubMed]; The synaptosome-associated protein 23 (SNAP23) is necessary for proper myogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35620", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0061025 membrane fusion;GO:0006887 exocytosis;GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane;GO:0098967 exocytic insertion of neurotransmitter receptor to postsynaptic membrane", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "O09044-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CG47-1", "uniprot_id": [ { "id": "SMC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CG47", "type": "external" } ], "mass": 146895.0, "length": 1286, "protein_name": "Structural maintenance of chromosomes protein 4", "gene_name": "Smc4", "organism": "Mouse", "refseq_name": "structural maintenance of chromosomes protein 4 isoform 1", "refseq_ac": [ { "id": "NP_598547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598547", "type": "external" } ], "gene_names_uniprotkb": "Smc4; Capc; Smc4l1", "gene_names_refseq": "2500002A22Rik; SMC-4; Smc4l1; Smc4", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein 4; Chromosome-associated polypeptide C; SMC protein 4; SMC-4; XCAP-C homolog", "protein_names_refseq": "SMC protein 4; SMC4 structural maintenance of chromosomes 4-like 1; XCAP-C homolog; chromosome-associated polypeptide C; structural maintenance of chromosomes protein 4 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70099); (R-MMU-2299718); (R-MMU-2514853)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "14660695;20173027;21750661;21952136;23806337;25153642;25428506;25428507;25605945;28528544;29043883;30084848;30779550;31219806;33649389;34428180;34887587;36181338;37170988;37828378;39627609", "class_list": "", "function": "Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Structural Maintenance of Chromosome Protein 4 Promotes the Progression of Cardia Adenocarcinoma via Regulation of the Wnt/beta-catenin Signaling Pathway., [RefSeq, PubMed]; Study examined the expression of SMC4 in acute myeloid leukemia (AML) pediatric patients cells and normal cells and revealed that SMC4 was significantly higher than control. Utilizing SMC4 gene knockdown in the established MLL-AF9 AML mouse model study found that SMC4 knockdown inhibited AML progression by maintaining leukemia stem cells., [RefSeq, PubMed]; TREM-1 induces pyroptosis in cardiomyocytes by activating NLRP3 inflammasome through the SMC4/NEMO pathway. Erratum:[FEBS J. 2025 Apr;292(8):2145. doi: 10.1111/febs.70066. PMID: 40098332], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTS7;Q8BTY9;Q99K21", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:1905820 positive regulation of chromosome separation;GO:0051383 kinetochore organization;GO:0051984 positive regulation of chromosome segregation;GO:0051301 cell division;GO:0021987 cerebral cortex development", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q8CG47-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BXN7-1", "uniprot_id": [ { "id": "PPM1K_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BXN7", "type": "external" } ], "mass": 40918.0, "length": 372, "protein_name": "Protein phosphatase Mn(2+)-dependent 1K", "gene_name": "Ppm1k", "organism": "Mouse", "refseq_name": "protein phosphatase Mn(2+)-dependent 1K precursor", "refseq_ac": [ { "id": "NP_780732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780732", "type": "external" } ], "gene_names_uniprotkb": "Ppm1k; Pp2cm", "gene_names_refseq": "2900063A19Rik; A930026L03Rik; BCKDH; BDP; PP2C-kappa; PP2Cm; Ppm1k", "protein_names_uniprotkb": "Protein phosphatase Mn(2+)-dependent 1K; 3.1.3.16; 3.1.3.52; BCKDH; BDP; Branched-chain alpha-ketoacid dehydrogenase phosphatase; PP2C-kappa; Protein phosphatase 2C family member; Protein phosphatase 2C isoform kappa; [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase", "protein_names_refseq": "[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase; branched-chain alpha-ketoacid dehydrogenase phosphatase; protein phosphatase 1K, mitochondrial; protein phosphatase 2C family member; protein phosphatase Mn(2+)-dependent 1K precursor; protein phosphatase Mn(2+)-dependent 1K", "tax_id": 10090, "disease": "mild variant of maple syrup urine disease (Disease Ontology:DOID:0061205); maple syrup urine disease (Disease Ontology:DOID:9269)", "pathway": " (mmu:243382); (R-MMU-70895)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17242355;17336929;17374715;19411760;21183079;21750661;22589535;36863088;37752100;38565071", "class_list": "", "function": "Data show that show that PP2Cm expression is highly enriched in brain, liver, kidney, but low in skeletal muscle., [RefSeq, PubMed]; MiR-743b-3p promotes hepatic lipogenesis via branched-chain amino acids (BCAA) metabolism by targeting PPM1K in aged mice., [RefSeq, PubMed]; PPM1K mediates metabolic disorder of branched-chain amino acid and regulates cerebral ischemia-reperfusion injury by activating ferroptosis in neurons. Publication Status: Online-Only, [RefSeq, PubMed]; PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome., [RefSeq, PubMed]; Serine/threonine-protein phosphatase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with BCKDK, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle (By similarity). At high levels of branched-chain ketoacids, dephosphorylates and activates mitochondrial BCKDH complex, a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Tightly associates with the E2 component of BCKDH complex and dephosphorylates BCKDHA on Ser-334 (By similarity). Regulates the reversible phosphorylation of ACLY in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. At fasting state, appears to dephosphorylate ACLY on Ser-455 and inactivate it. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (By similarity). Recognizes phosphosites having SxS or RxxS motifs and strictly depends on Mn(2+) ions for the phosphatase activity (By similarity). Regulates Ca(2+)-induced opening of mitochondrial transition pore and apoptotic cell death (By similarity) (PubMed:17374715, PubMed:19411760)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.2.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.4", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0047385 [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0009083 branched-chain amino acid catabolic process;GO:1902531 regulation of intracellular signal transduction;GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BXN7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17208-1", "uniprot_id": [ { "id": "PO4F1_MOUSE", "url": "https://www.uniprot.org/uniprot/P17208", "type": "external" } ], "mass": 42767.0, "length": 421, "protein_name": "POU domain, class 4, transcription factor 1", "gene_name": "Pou4f1", "organism": "Mouse", "refseq_name": "POU domain, class 4, transcription factor 1", "refseq_ac": [ { "id": "NP_035273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035273", "type": "external" } ], "gene_names_uniprotkb": "Pou4f1; Brn-3; Brn3a; Brn3", "gene_names_refseq": "Brn-3.0; Brn-3; Brn3.0; Brn3a; Brn3; E130119J07Rik; Pou4f1", "protein_names_uniprotkb": "POU domain, class 4, transcription factor 1; Brain-3A; Brain-specific homeobox/POU domain protein 3A; Brn-3.0; Brn-3A", "protein_names_refseq": "POU domain, class 4, transcription factor 1; brain-3A; brain-specific homeobox/POU domain protein 3A; brn-3A", "tax_id": 10090, "disease": "", "pathway": " (mmu:18996); (R-MMU-6804759)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10640682;12441296;12934100;17668438;1970171;22326227;8162704;8290353;8537352;8621561;8637595;8876243;8972215;9448000;9694219;9722627", "class_list": "", "function": "Able to act as a transcription factor, cannot regulate the expression of the same subset of genes as isoform 1 (PubMed:12934100). Does not have an antiapoptotic effect on neuronal cells (PubMed:9722627)., [UniProtKB, PubMed, PubMed]; Multifunctional transcription factor with different regions mediating its different effects (PubMed:10640682, PubMed:8621561, PubMed:9694219, PubMed:9722627). Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:17668438, PubMed:8621561). Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor (PubMed:12934100). Activates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain) (PubMed:9722627). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins (PubMed:8972215). Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity (PubMed:9448000). May positively regulate POU4F2 and POU4F3 (PubMed:8876243). Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord (PubMed:22326227). Plays a role in TNFSF11-mediated terminal osteoclast differentiation (PubMed:17668438). Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site (PubMed:12441296)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QPT6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0051020 GTPase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0043005 neuron projection;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0060384 innervation;GO:0048880 sensory system development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001967 suckling behavior;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P17208-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20263-1", "uniprot_id": [ { "id": "PO5F1_MOUSE", "url": "https://www.uniprot.org/uniprot/P20263", "type": "external" } ], "mass": 38216.0, "length": 352, "protein_name": "POU domain, class 5, transcription factor 1", "gene_name": "Pou5f1", "organism": "Mouse", "refseq_name": "POU domain, class 5, transcription factor 1 isoform 1", "refseq_ac": [ { "id": "NP_038661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038661", "type": "external" } ], "gene_names_uniprotkb": "Pou5f1; Oct-3; Oct-4; Otf-3; Otf3", "gene_names_refseq": "NF-A3; Oct-3/4; Oct-3; Oct-4; Oct3/4; Oct3; Oct4; Otf-3; Otf-4; Otf3-rs7; Otf3g; Otf3; Otf4; Pou5f1", "protein_names_uniprotkb": "POU domain, class 5, transcription factor 1; NF-A3; OTF-3; Oct-3; Oct-4; Octamer-binding protein 3; Octamer-binding protein 4; Octamer-binding transcription factor 3", "protein_names_refseq": "POU domain, class 5, transcription factor 1 isoform 1; octamer-binding protein 3; octamer-binding protein 4; octamer-binding transcription factor 3; octamer-binding transcription factor 4 alternative", "tax_id": 10090, "disease": "transitional cell carcinoma (Disease Ontology:DOID:2671); embryonal carcinoma (Disease Ontology:DOID:3308); seminoma (Disease Ontology:DOID:4440); dysgerminoma (Disease Ontology:DOID:4441); in situ carcinoma (Disease Ontology:DOID:8719)", "pathway": " (mmu:18999)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "11702949;15831456;15863505;16904174;1690859;17097055;17496161;17525163;18662995;18687992;1915274;1967980;1972777;19740739;19997087;21750661;22608532;23376973;23495099;24550733;27311888;27984042;29153991;32703285;33451972;36852467;40128797;8097478", "class_list": "glycogene", "function": "The protein encoded by this gene belongs to the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein plays a key role in embryonic development and stem cell pluripotency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]., [RefSeq]; Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:1690859, PubMed:17525163, PubMed:1967980, PubMed:1972777, PubMed:23376973). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (PubMed:15863505, PubMed:17097055, PubMed:17496161, PubMed:19740739). Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:1690859, PubMed:17496161, PubMed:18662995, PubMed:18687992, PubMed:1972777, PubMed:19740739, PubMed:23376973, PubMed:29153991, PubMed:32703285)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 17, "reported_glycation": 0, "reported_snv": 30, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q63843", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0031625 ubiquitin protein ligase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0009786 regulation of asymmetric cell division;GO:0001714 endodermal cell fate specification;GO:0001710 mesodermal cell fate commitment;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P20263-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000001001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24369-1", "uniprot_id": [ { "id": "PPIB_MOUSE", "url": "https://www.uniprot.org/uniprot/P24369", "type": "external" } ], "mass": 23713.0, "length": 216, "protein_name": "Peptidyl-prolyl cis-trans isomerase B", "gene_name": "Ppib", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase B precursor", "refseq_ac": [ { "id": "NP_035279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035279", "type": "external" } ], "gene_names_uniprotkb": "Ppib", "gene_names_refseq": "Cphn-2; Cphn2; CyP-20b; Ppib", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase B; 5.2.1.8; CYP-S1; Cyclophilin B; PPIase B; Rotamase B; S-cyclophilin; SCYLP", "protein_names_refseq": "CYP-S1; PPIase B; S-cyclophilin; SCYLP; cyclophilin B; peptidyl-prolyl cis-trans isomerase B precursor; peptidyl-prolyl cis-trans isomerase B; rotamase B", "tax_id": 10090, "disease": "osteogenesis imperfecta type 9 (Disease Ontology:DOID:0110349)", "pathway": " (mmu:19035); (R-MMU-1650814)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;1710767;1756174;23806337;25967121;34428180;35984892;37453647;37507081;38427624", "class_list": "", "function": "Mice lacking cyclophilin B, but not cyclophilin A, are protected from the development of NASH in a diet and chemical-induced model. Publication Status: Online-Only, [RefSeq, PubMed]; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.14.11.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.7", "type": "external" } ], "go_molecular_function": "GO:0070063 RNA polymerase binding;GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0044829 host-mediated activation of viral genome replication;GO:0050821 protein stabilization;GO:0006457 protein folding;GO:0060348 bone development;GO:0044794 host-mediated activation of viral process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P24369-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UZD5-1", "uniprot_id": [ { "id": "PRDM6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UZD5", "type": "external" } ], "mass": 64503.0, "length": 596, "protein_name": "Putative histone-lysine N-methyltransferase PRDM6", "gene_name": "Prdm6", "organism": "Mouse", "refseq_name": "putative histone-lysine N-methyltransferase PRDM6", "refseq_ac": [ { "id": "NP_001028453", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028453", "type": "external" } ], "gene_names_uniprotkb": "Prdm6; Gm92; Prism", "gene_names_refseq": "Gm92; PRISM; Prdm6", "protein_names_uniprotkb": "Putative histone-lysine N-methyltransferase PRDM6; 2.1.1.361; PR domain zinc finger protein 6; PR domain-containing protein 6; PR domain-containing protein in smooth muscle", "protein_names_refseq": "PR domain-containing protein 6; PR domain-containing protein in smooth muscle; PR-domain zinc finger protein 6; putative histone-lysine N-methyltransferase PRDM6", "tax_id": 10090, "disease": "patent ductus arteriosus (Disease Ontology:DOID:13832)", "pathway": " (mmu:225518)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16537907;17662997;21750661;25428506;27181681;35108221;36749647", "class_list": "", "function": "PRISM acts as a novel epigenetic regulator of Smooth Muscle Cells (SMC) phenotypic plasticity by suppressing differentiation and maintaining the proliferative potential of vascular SMCs., [RefSeq, PubMed]; Prdm6 controls heart development by regulating neural crest cell differentiation and migration. Publication Status: Online-Only, [RefSeq, PubMed]; Prdm6 drives ductus arteriosus closure by promoting ductus arteriosus smooth muscle cell identity and contractility. Publication Status: Online-Only, [RefSeq, PubMed]; Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression (PubMed:16537907, PubMed:17662997). Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells (PubMed:16537907, PubMed:17662997, PubMed:27181681). Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a (PubMed:16537907). According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (PubMed:17662997)., [UniProtKB, PubMed, PubMed, PubMed]; These data indicate that PRDM6 is expressed by vascular precursors, has differential effects in endothelial cells and smooth muscle cells, and may play a role in vascular precursor differentiation and survival., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EIB0;Q2I2X0;Q2I2X1;Q3UX75", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0140944 histone H4K20 monomethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0051151 negative regulation of smooth muscle cell differentiation;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3UZD5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TL0-1", "uniprot_id": [ { "id": "PPM1E_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TL0", "type": "external" } ], "mass": 83419.0, "length": 749, "protein_name": "Protein phosphatase 1E", "gene_name": "Ppm1e", "organism": "Mouse", "refseq_name": "protein phosphatase 1E", "refseq_ac": [ { "id": "NP_796141", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796141", "type": "external" } ], "gene_names_uniprotkb": "Ppm1e; Camkn; Kiaa1072", "gene_names_refseq": "B930008A12Rik; POPX1; PP2CH; Ppm1e; mKIAA1072", "protein_names_uniprotkb": "Protein phosphatase 1E; 3.1.3.16; Ca(2+)/calmodulin-dependent protein kinase phosphatase N; CaMKN; CaMKP-N; CaMKP-nucleus; Partner of PIX 1; Partner of PIX-alpha; Partner of PIXA", "protein_names_refseq": "ca(2+)/calmodulin-dependent protein kinase phosphatase N; caMKN; caMKP-N; caMKP-nucleus; partner of PIX 1; partner of PIX-alpha; partner of PIXA; protein phosphatase 1E", "tax_id": 10090, "disease": "", "pathway": " (mmu:320472)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21183079;22872234;23088624;31219806;34203471;34428180", "class_list": "", "function": "Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2. Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42 (By similarity). Dephosphorylates PRKAA2., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5SX30;Q8BGM6;Q8CB81", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007165 signal transduction;GO:0006469 negative regulation of protein kinase activity;GO:0071466 cellular response to xenobiotic stimulus;GO:0071222 cellular response to lipopolysaccharide;GO:0051496 positive regulation of stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q80TL0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64700-1", "uniprot_id": [ { "id": "RBL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64700", "type": "external" } ], "mass": 127485.0, "length": 1135, "protein_name": "Retinoblastoma-like protein 2", "gene_name": "Rbl2", "organism": "Mouse", "refseq_name": "retinoblastoma-like protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001268929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268929", "type": "external" } ], "gene_names_uniprotkb": "Rbl2", "gene_names_refseq": "PRB2; RBR-2; Rb2; Rbl2; p130", "protein_names_uniprotkb": "Retinoblastoma-like protein 2; 130 kDa retinoblastoma-associated protein; RBR-2; Retinoblastoma-related protein 2; p130; pRb2", "protein_names_refseq": "130 kDa retinoblastoma-associated protein; retinoblastoma-like 2; retinoblastoma-like protein 2 isoform 2; retinoblastoma-related protein 2", "tax_id": 10090, "disease": "Brunet-Wagner neurodevelopmental syndrome (Disease Ontology:DOID:0061126); prostate cancer (Disease Ontology:DOID:10283); intellectual disability (Disease Ontology:DOID:1059); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:19651); (R-MMU-1538133); (R-MMU-69231)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "11571651;15750587;17242355;21183079;21750661;25605945;34203471;34428180;35822049;36210013;36542833;8621630;8622859;9019172", "class_list": "", "function": "Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVP8", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:1990841 promoter-specific chromatin binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q64700-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80UJ7-1", "uniprot_id": [ { "id": "RB3GP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80UJ7", "type": "external" } ], "mass": 110198.0, "length": 981, "protein_name": "Rab3 GTPase-activating protein catalytic subunit", "gene_name": "Rab3gap1", "organism": "Mouse", "refseq_name": "rab3 GTPase-activating protein catalytic subunit isoform 2", "refseq_ac": [ { "id": "NP_848805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848805", "type": "external" } ], "gene_names_uniprotkb": "Rab3gap1; Kiaa0066; Rab3gap", "gene_names_refseq": "1700003B17Rik; 4732493F09Rik; Rab3gap1; Rab3gap; p130; rab3-GAP p130", "protein_names_uniprotkb": "Rab3 GTPase-activating protein catalytic subunit; RAB3 GTPase-activating protein 130 kDa subunit; Rab3-GAP p130; Rab3-GAP", "protein_names_refseq": "RAB3 GTPase-activating protein 130 kDa subunit; rab3 GTPase-activating protein catalytic subunit isoform 2; rab3 GTPase-activating protein catalytic subunit", "tax_id": 10090, "disease": "Warburg micro syndrome (Disease Ontology:DOID:0060237); Warburg micro syndrome 1 (Disease Ontology:DOID:0110716)", "pathway": " (mmu:226407); (R-MMU-6811436); (R-MMU-8876198)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "15696165;21183079;21750661;21825075;26495903;30084848;30779550;37828378", "class_list": "", "function": "Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which accelerates the otherwise slow GTP hydrolysis catalyzed by Rab proteins. Has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43. Additionally, it has guanine nucleotide exchange factor (GEF) activity towards RAB18, promoting GDP release from RAB18 and the conversion of inactive RAB18-GDP to the active form RAB18-GTP. Recruits and stabilizes RAB18 at the cis-Golgi membrane in fibroblasts where RAB18 is most likely activated. Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure. Required for normal eye and brain development. May participate in neurodevelopmental processes such as cell proliferation, migration and differentiation before synapse formation, and is involved in regulating non-synaptic vesicular release of neurotransmitters., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Rb and p130 have overlapping roles in maintaining the postmitotic state of adult cardiac myocytes through their interaction with HP1-gamma to direct heterochromatin formation and silencing of proliferation-promoting genes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPB6;Q6A0D7;Q8C4Y0;Q8C679;Q8C6A5;Q8K324", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0098794 postsynapse;GO:0005801 cis-Golgi network;GO:0032991 protein-containing complex;GO:0071782 endoplasmic reticulum tubular network", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0097051 establishment of protein localization to endoplasmic reticulum membrane;GO:0010628 positive regulation of gene expression;GO:0060079 excitatory postsynaptic potential;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80UJ7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35283-1", "uniprot_id": [ { "id": "RAB12_MOUSE", "url": "https://www.uniprot.org/uniprot/P35283", "type": "external" } ], "mass": 27329.0, "length": 243, "protein_name": "Ras-related protein Rab-12", "gene_name": "Rab12", "organism": "Mouse", "refseq_name": "ras-related protein Rab-12", "refseq_ac": [ { "id": "NP_077768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077768", "type": "external" } ], "gene_names_uniprotkb": "Rab12", "gene_names_refseq": "2900054P15Rik; Rab12", "protein_names_uniprotkb": "Ras-related protein Rab-12; 3.6.5.2; Rab-13", "protein_names_refseq": "rab-13; ras-related protein Rab-12", "tax_id": 10090, "disease": "Smith-McCort dysplasia (Disease Ontology:DOID:0060247); Dyggve-Melchior-Clausen disease (Disease Ontology:DOID:0111167)", "pathway": " (mmu:19328); (R-MMU-8873719); (R-MMU-8876198)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "1555775;16923123;17114649;19131326;19144319;21183079;21718402;21750661;23357852;24719330;26740112;26824392;29125462;33135724;34428180;37507081;37828378;37874635", "class_list": "", "function": "Dennd3 not only functions as a Rab12-GEF but also modulates Akt signaling in mouse embryonic fibroblast cells, [RefSeq, PubMed]; Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase. Publication Status: Online-Only, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB12 may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor (PubMed:21718402). Involved in autophagy (PubMed:23357852)., [UniProtKB, PubMed, PubMed, UniProtKB]; We identified the small GTPase Rab12 as a novel regulator of mast cell secretory granule transport, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0PD43;Q9CUW7", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0030141 secretory granule;GO:0005764 lysosome", "go_biological_process": "GO:0015031 protein transport;GO:0006914 autophagy;GO:0008333 endosome to lysosome transport;GO:0016239 positive regulation of macroautophagy;GO:0071346 cellular response to type II interferon", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P35283-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34022-1", "uniprot_id": [ { "id": "RANG_MOUSE", "url": "https://www.uniprot.org/uniprot/P34022", "type": "external" } ], "mass": 23596.0, "length": 203, "protein_name": "Ran-specific GTPase-activating protein", "gene_name": "Ranbp1", "organism": "Mouse", "refseq_name": "ran-specific GTPase-activating protein", "refseq_ac": [ { "id": "NP_035369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035369", "type": "external" } ], "gene_names_uniprotkb": "Ranbp1; Htf9-a; Htf9a", "gene_names_refseq": "Htf9a; Ranbp1", "protein_names_uniprotkb": "Ran-specific GTPase-activating protein; HpaII tiny fragments locus 9a protein; RANBP1; Ran-binding protein 1", "protein_names_refseq": "Htf9-a/RanBP1; hpaII tiny fragments locus 9a protein; ran-binding protein 1; ran-specific GTPase-activating protein", "tax_id": 10090, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); dilated cardiomyopathy (Disease Ontology:DOID:12930); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:19385)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "17242355;1889746;21183079;21750661;22645316;23806337;25153642;25452572;26495903;26740625;28135057;28528544;31599954;35820727;36288343;36790128;7891706;8255297;8896452;9428644", "class_list": "", "function": "Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (PubMed:9428644). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (PubMed:9428644). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (By similarity). Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:9428644). Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Ranbp1 emerges as a microcephaly gene within the 22q11.2 deleted region that may contribute to altered cortical precursor proliferation and neurogenesis associated with broader 22q11.2 deletion., [RefSeq, PubMed]; Ranbp1 modulates morphogenesis of the craniofacial midline in mouse models of 22q11.2 deletion syndrome., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P34023;Q3TL81;Q9D894;Q9DCA3", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0051168 nuclear export;GO:0007051 spindle organization;GO:0046604 positive regulation of mitotic centrosome separation;GO:0006913 nucleocytoplasmic transport", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P34022-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U0S6-1", "uniprot_id": [ { "id": "RAIN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U0S6", "type": "external" } ], "mass": 103559.0, "length": 961, "protein_name": "Ras-interacting protein 1", "gene_name": "Rasip1", "organism": "Mouse", "refseq_name": "ras-interacting protein 1", "refseq_ac": [ { "id": "NP_082820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082820", "type": "external" } ], "gene_names_uniprotkb": "Rasip1", "gene_names_refseq": "1110025D03Rik; 2610025P08Rik; Rain; Rasip1", "protein_names_uniprotkb": "Ras-interacting protein 1; Rain", "protein_names_refseq": "ras-interacting protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69903)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;15031288;17242355;19272373;21183079;21396893;24129315;27486147;30042182;34428180", "class_list": "", "function": "Mice lacking Rasip1 fail to form patent lumens in all blood vessels, including the early endocardial tube. Rasipl null angioblasts fail to properly localize the polarity determinant Par3 and display defective cell polarity., [RefSeq, PubMed]; Rain is a novel protein that can serve as an effector of endomembrane-localized Ras, [RefSeq, PubMed]; Rasip1 controls different pools of GTPases, which in turn regulates blood vessel tubulogenesis., [RefSeq, PubMed]; Rasip1 expression is undetectable in VEGFR2 null embryos, which lack endothelial cells, suggesting that Rasip1 is endothelial specific. siRNA-mediated reduction of Rasip1 severely impairs angiogenesis and motility in endothelial cell cultures, [RefSeq, PubMed]; Rasip1 regulates Cdc42 activity to regulate cell junctions and cytoskeleton organization, which are both activities required for lymphatic lumen maintenance Publication Status: Online-Only, [RefSeq, PubMed]; Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells. May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy (By similarity)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QLI7;Q6GQW4", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0051020 GTPase binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005911 cell-cell junction;GO:0048471 perinuclear region of cytoplasm;GO:0005795 Golgi stack;GO:0032991 protein-containing complex", "go_biological_process": "GO:2000299 negative regulation of Rho-dependent protein serine/threonine kinase activity;GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0007165 signal transduction;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3U0S6-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UQS8-1", "uniprot_id": [ { "id": "RBM20_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UQS8", "type": "external" } ], "mass": 130124.0, "length": 1199, "protein_name": "RNA-binding protein 20", "gene_name": "Rbm20", "organism": "Mouse", "refseq_name": "RNA-binding protein 20", "refseq_ac": [ { "id": "NP_001164318", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164318", "type": "external" } ], "gene_names_uniprotkb": "Rbm20", "gene_names_refseq": "1110018J23Rik; 2010003H22Rik; Rbm20", "protein_names_uniprotkb": "RNA-binding protein 20; RNA-binding motif protein 20", "protein_names_refseq": "RNA-binding protein 20; probable RNA-binding protein 20", "tax_id": 10090, "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); dilated cardiomyopathy 1DD (Disease Ontology:DOID:0110447); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:73713)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "21183079;21750661;22466703;23886709;24584570;27630136;29650543;29895960;30084848;32187365;33110103;35041844;35394688;37272356", "class_list": "", "function": "Nuclear retention domains have been identified in RBM20 which is a nuclear protein regulating alternative splicing of expressed genes., [RefSeq, PubMed]; RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:24584570, PubMed:27630136, PubMed:29650543, PubMed:29895960, PubMed:33110103, PubMed:35041844, PubMed:35394688). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:32187365). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:27630136, PubMed:29895960, PubMed:33110103, PubMed:35041844). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (PubMed:37272356). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Study demonstrates that Rbm20 is expressed in early cardiogenesis and functions in the patterning of cardiac gene expression., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9PVK0;Q8CFS9", "ec_number_list": [], "go_molecular_function": "GO:0097157 pre-mRNA intronic binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:1990935 splicing factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0043484 regulation of RNA splicing;GO:0048024 regulation of mRNA splicing, via spliceosome;GO:0060914 heart formation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q3UQS8-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U3K5-1", "uniprot_id": [ { "id": "RABL6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5U3K5", "type": "external" } ], "mass": 79831.0, "length": 725, "protein_name": "Rab-like protein 6", "gene_name": "Rabl6", "organism": "Mouse", "refseq_name": "rab-like protein 6", "refseq_ac": [ { "id": "NP_001019787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019787", "type": "external" } ], "gene_names_uniprotkb": "Rabl6; Parf", "gene_names_refseq": "B230208H17Rik; Rabl6; Rbel1a; Rbel1b; Rbel1; parf", "protein_names_uniprotkb": "Rab-like protein 6; 3.6.5.2; GTP-binding protein Parf; RBEL1; Rab-like protein 1", "protein_names_refseq": "RAB, member of RAS oncogene family-like 6; putative GTP-binding protein Parf; rab-like protein 1; rab-like protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:227624)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17242355;19131326;21183079;23572512;33300544;34428180;35820727", "class_list": "", "function": "RBEL1A appears to function as a novel p53 negative regulator that facilitates MDM2-dependent p53 ubiquitylation and degradation., [RefSeq, PubMed]; Small GTPase involved in the regulation of cell growth and survival. Promotes cellular proliferation. May reduce growth inhibitory activity of CDKN2A., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AJB0;Q3TAT5;Q3TRU4;Q6PDP8;Q8BFS4;Q8CGJ9", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0034451 centriolar satellite", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q5U3K5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHC1-1", "uniprot_id": [ { "id": "RB39B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHC1", "type": "external" } ], "mass": 24636.0, "length": 213, "protein_name": "Ras-related protein Rab-39B", "gene_name": "Rab39b", "organism": "Mouse", "refseq_name": "ras-related protein Rab-39B", "refseq_ac": [ { "id": "NP_780331", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780331", "type": "external" } ], "gene_names_uniprotkb": "Rab39b", "gene_names_refseq": "6330580M05Rik; Rab39b", "protein_names_uniprotkb": "Ras-related protein Rab-39B; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-39B", "tax_id": 10090, "disease": "syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); Waisman syndrome (Disease Ontology:DOID:0111781); non-syndromic X-linked intellectual disability 72 (Disease Ontology:DOID:0112059)", "pathway": " (mmu:67790); (R-MMU-8873719); (R-MMU-8876198)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "20159109;21183079;23294242;23624502;25434005;25784538;31651360;33300544;34035473;34761259;36977207", "class_list": "", "function": "Clinical characterization of a novel RAB39B nonstop mutation in a family with ASD and severe ID causing RAB39B downregulation and study of a Rab39b knock down mouse model., [RefSeq, PubMed]; Increased level of RAB39B leads to neuronal dysfunction and behavioural changes in mice., [RefSeq, PubMed]; RAB39B-mediated trafficking of the GluA2-AMPAR subunit controls dendritic spine maturation and intellectual disability-related behaviour., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:20159109, PubMed:25784538). RAB39B is involved in autophagy and may function in autophagosome formation (By similarity). Binds downstream effector PICK1 to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR composition at the post-synapses and thus synaptic transmission (PubMed:25784538). May regulate the homeostasis of SNCA/alpha-synuclein (PubMed:25434005)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; These results demonstrate developmental and functional neuronal alteration as a consequence of downregulation of RAB39B and emphasize the critical role of vesicular trafficking in the development of neurons and human intellectual abilities., [RefSeq, PubMed]; This gene encodes a member of the Ras-related small GTPases, which regulate membrane trafficking in organelles and transport vesicles. This protein has been reported to be enriched in mouse brain, and specifically within neurons, and may play a role in synapse formation. In humans mutations in this gene are associated with X-linked cognitive disability. [provided by RefSeq, Jun 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUJ3", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031489 myosin V binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0015031 protein transport;GO:0050808 synapse organization;GO:0006914 autophagy;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BHC1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BQP9-1", "uniprot_id": [ { "id": "R7BP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BQP9", "type": "external" } ], "mass": 29023.0, "length": 257, "protein_name": "Regulator of G protein signaling 7-binding protein", "gene_name": "Rgs7bp", "organism": "Mouse", "refseq_name": "regulator of G-protein signaling 7-binding protein", "refseq_ac": [ { "id": "NP_084155", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084155", "type": "external" } ], "gene_names_uniprotkb": "Rgs7bp; D13Bwg1146e; R7bp", "gene_names_refseq": "A930030I01Rik; D13Bwg1146e; R7bp; Rgs7bp", "protein_names_uniprotkb": "Regulator of G protein signaling 7-binding protein; R7 family-binding protein", "protein_names_refseq": "R7 binding protein; R7 family-binding protein; regulator of G-protein signaling 7-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:52882)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15632198;15897264;16046666;16574655;16867977;17158100;21343290;28134655", "class_list": "", "function": "All four R7 RGS proteins co-precipitate with R7BP from brain extracts and recombinant R7 proteins bind recombinant R7BP with high efficiency, [RefSeq, PubMed]; Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Review. R7BP transduces signals directly from receptors and G proteins at the plasma membrane to the nucleus, and this plasma membrane-nuclear shuttling is controlled by reversible palmitoylation of R7BP. Review article Publication Status: Online-Only, [RefSeq, PubMed]; The results of this study indicated that R7bp is a key regulator of itch sensation and suggest the potential targeting of R7bp-dependent GTPase activating protein activity as a novel therapeutic strategy for pathological itch, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VF69;Q3UVC4;Q8CBD6;Q9CTP1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0009968 negative regulation of signal transduction;GO:0060078 regulation of postsynaptic membrane potential", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BQP9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C2K5-1", "uniprot_id": [ { "id": "RASL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C2K5", "type": "external" } ], "mass": 114782.0, "length": 1041, "protein_name": "RAS protein activator like-3", "gene_name": "Rasal3", "organism": "Mouse", "refseq_name": "RAS protein activator like-3 isoform 1", "refseq_ac": [ { "id": "NP_001334272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334272", "type": "external" } ], "gene_names_uniprotkb": "Rasal3", "gene_names_refseq": "A430107D22Rik; Rasal3", "protein_names_uniprotkb": "RAS protein activator like-3", "protein_names_refseq": "RAS protein activator like-3 isoform 1", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037)", "pathway": " (mmu:320484); (R-MMU-5658442)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21183079;21750661;25652366;25793935;29291408;34428180;34777356;38200184", "class_list": "", "function": "CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis. Publication Status: Online-Only, [RefSeq, PubMed]; Collectively, Rasal3 controls the magnitude of inflammatory responses through the survival of both naive T cells and activated T cells in vivo., [RefSeq, PubMed]; Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway., [UniProtKB, PubMed]; RASAL3 Is a Putative RasGAP Modulating Inflammatory Response by Neutrophils. Publication Status: Online-Only, [RefSeq, PubMed]; Rasal3 is required for in vivo survival of peripheral naive T cells, contributing to the maintenance of optimal T cell numbers. Publication Status: Online-Only, [RefSeq, PubMed]; Results suggest that RASAL3 plays an important role in the expansion and functions of NKT cells in the liver by negatively regulating Ras/Erk signaling, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A3KMM0;Q8C2A5;Q8C9R4;Q8CDB4", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0098562 cytoplasmic side of membrane", "go_biological_process": "GO:0051142 positive regulation of NK T cell proliferation;GO:0046580 negative regulation of Ras protein signal transduction;GO:1902531 regulation of intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8C2K5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K0S5-1", "uniprot_id": [ { "id": "R4RL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K0S5", "type": "external" } ], "mass": 49836.0, "length": 445, "protein_name": "Reticulon-4 receptor-like 1", "gene_name": "Rtn4rl1", "organism": "Mouse", "refseq_name": "reticulon-4 receptor-like 1 precursor", "refseq_ac": [ { "id": "NP_808376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808376", "type": "external" } ], "gene_names_uniprotkb": "Rtn4rl1; Ngrl2", "gene_names_refseq": "Ngr3; Ngrh2; Ngrl2; Rtn4rl1", "protein_names_uniprotkb": "Reticulon-4 receptor-like 1; NgR3; Nogo receptor-like 2; Nogo-66 receptor homolog 2; Nogo-66 receptor-related protein 3", "protein_names_refseq": "nogo receptor-like 2; nogo-66 receptor homolog 2; nogo-66 receptor-related protein 3; reticulon-4 receptor-like 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:237847)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;12839991;14664809;18322192;22325200;22406547;25428506;26335717;27339102;29187734;30899004;31219806;33300544", "class_list": "", "function": "Cell surface receptor that plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system (PubMed:22406547, PubMed:27339102). Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum (PubMed:27339102). Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (PubMed:26335717). Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans (PubMed:22406547). Binds heparin (PubMed:22406547). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Predominantly expressed in the neurons of the embryonic and adult nervous systems, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0035374 chondroitin sulfate binding;GO:0048495 Roundabout binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043204 perikaryon;GO:0045121 membrane raft;GO:0042995 cell projection", "go_biological_process": "GO:0010977 negative regulation of neuron projection development;GO:0050919 negative chemotaxis;GO:0007411 axon guidance;GO:0022038 corpus callosum development;GO:0048681 negative regulation of axon regeneration", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8K0S5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQT2-1", "uniprot_id": [ { "id": "RBM7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQT2", "type": "external" } ], "mass": 30148.0, "length": 265, "protein_name": "RNA-binding protein 7", "gene_name": "Rbm7", "organism": "Mouse", "refseq_name": "RNA-binding protein 7 isoform 1", "refseq_ac": [ { "id": "NP_659197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659197", "type": "external" } ], "gene_names_uniprotkb": "Rbm7", "gene_names_refseq": "1200007M24Rik; 1500011D06Rik; Rbm7", "protein_names_uniprotkb": "RNA-binding protein 7; RNA-binding motif protein 7", "protein_names_refseq": "RNA-binding protein 7 isoform 1; RNA-binding protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:67010); (R-MMU-72163); (R-MMU-9930044)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;25525152;25605945;31219806;34428180;34678516", "class_list": "", "function": "RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre-mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRNAs). Participates in several biological processes including DNA damage response (DDR) and stress response. During stress response, activation of the p38MAPK-MK2 pathway decreases RBM7-RNA-binding and subsequently the RNA exosome degradation activities, thereby modulating the turnover of non-coding transcriptome. Participates in DNA damage response (DDR), through its interaction with MEPCE and LARP7, the core subunits of 7SK snRNP complex, that release the positive transcription elongation factor b (P-TEFb) complex from the 7SK snRNP. In turn, activation of P-TEFb complex induces the transcription of P-TEFb-dependent DDR genes to promote cell viability., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UB91;Q7TQE3", "ec_number_list": [], "go_molecular_function": "GO:0097157 pre-mRNA intronic binding;GO:0003723 RNA binding;GO:0003727 single-stranded RNA binding;GO:0071889 14-3-3 protein binding;GO:0017069 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0062141 nuclear exosome targeting complex", "go_biological_process": "GO:0051321 meiotic cell cycle;GO:0000381 regulation of alternative mRNA splicing, via spliceosome;GO:0016076 snRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9CQT2-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AB59-1", "uniprot_id": [ { "id": "RHG27_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AB59", "type": "external" } ], "mass": 97049.0, "length": 869, "protein_name": "Rho GTPase-activating protein 27", "gene_name": "Arhgap27", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 27 isoform 1", "refseq_ac": [ { "id": "NP_001192165", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192165", "type": "external" } ], "gene_names_uniprotkb": "Arhgap27; Camgap1", "gene_names_refseq": "2310069I04Rik; 5730442P18Rik; Arhgap27; Gm21552; Sh3d20", "protein_names_uniprotkb": "Rho GTPase-activating protein 27; CIN85-associated multi-domain-containing Rho GTPase-activating protein 1; Rho-type GTPase-activating protein 27", "protein_names_refseq": "CIN85-associated multi-domain-containing Rho GTPase-activating protein 1; SH3 domain containing 20; rho GTPase-activating protein 27 isoform 1; rho-type GTPase-activating protein 27", "tax_id": 10090, "disease": "", "pathway": " (mmu:544817); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15147912;17242355;18034455;21183079;21750661;25428506;39627609", "class_list": "", "function": "Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V366;Q4V9V5", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0007266 Rho protein signal transduction;GO:0007264 small GTPase-mediated signal transduction;GO:0006898 receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A2AB59-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FWK3-1", "uniprot_id": [ { "id": "RHG01_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5FWK3", "type": "external" } ], "mass": 50411.0, "length": 439, "protein_name": "Rho GTPase-activating protein 1", "gene_name": "Arhgap1", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001139374", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139374", "type": "external" } ], "gene_names_uniprotkb": "Arhgap1", "gene_names_refseq": "Arhgap1; B230365D05Rik; Cdc42GAP; p50rhoGAP", "protein_names_uniprotkb": "Rho GTPase-activating protein 1; Rho-type GTPase-activating protein 1", "protein_names_refseq": "rho GTPase-activating protein 1 isoform 1; rho GTPase-activating protein 1; rho-type GTPase-activating protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:228359); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013408); (R-MMU-9013409); (R-MMU-9013423); (R-MMU-9035034); (R-MMU-9696270)", "pathway_count": 13, "publication_count": 10, "publication_id_list": "17947660;21183079;21750661;30630384;34006635;34428180;35984892;36210013;37254741;37828378", "class_list": "", "function": "ARHGAP 18 is a protective gene that maintains EC alignments in the direction of flow. Deletion of ARHGAP 18 led to loss of EC ability to align and promoted, [RefSeq, PubMed]; Cdc42GAP deficiency contributes to the Alzheimer's disease phenotype., [RefSeq, PubMed]; GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate (By similarity)., [UniProtKB]; Structural basis for p50RhoGAP BCH domain-mediated regulation of Rho inactivation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C3X5;Q923D8", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0017124 SH3 domain binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0031252 cell leading edge", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0016197 endosomal transport;GO:0033572 transferrin transport;GO:2001136 negative regulation of endocytic recycling;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q5FWK3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6X8Z5-1", "uniprot_id": [ { "id": "RHG31_MOUSE", "url": "https://www.uniprot.org/uniprot/A6X8Z5", "type": "external" } ], "mass": 155276.0, "length": 1425, "protein_name": "Rho GTPase-activating protein 31", "gene_name": "Arhgap31", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 31", "refseq_ac": [ { "id": "NP_064656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064656", "type": "external" } ], "gene_names_uniprotkb": "Arhgap31; Cdgap; Kiaa1204", "gene_names_refseq": "5830477L08Rik; Arhgap31; Cdgap; D330026I07Rik", "protein_names_uniprotkb": "Rho GTPase-activating protein 31; Cdc42 GTPase-activating protein", "protein_names_refseq": "CDC42 GTPase-activating protein; rho GTPase-activating protein 31", "tax_id": 10090, "disease": "Adams-Oliver syndrome (Disease Ontology:DOID:0060227); coronary artery disease (Disease Ontology:DOID:3393)", "pathway": " (mmu:12549); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013420)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11744688;16024771;16860736;17158447;17242355;21183079;27270835;31219806;32782141;34428180;36333327;9786927", "class_list": "", "function": "CdGAP maintains podocyte function and modulates focal adhesions in a Src kinase-dependent manner. Publication Status: Online-Only, [RefSeq, PubMed]; Findings are the first to demonstrate the importance of CdGAP in embryonic vascular development and VEGF-induced signaling, and highlight CdGAP as a potential therapeutic target to treat pathological angiogenesis and vascular dysfunction Publication Status: Online-Only, [RefSeq, PubMed]; Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3TL91;Q3U1T7;Q3UDE7;Q3UUH4;Q6ZPW0;Q9WV94", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0005925 focal adhesion;GO:0030027 lamellipodium", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "A6X8Z5-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97348-1", "uniprot_id": [ { "id": "RHOD_MOUSE", "url": "https://www.uniprot.org/uniprot/P97348", "type": "external" } ], "mass": 23562.0, "length": 210, "protein_name": "Rho-related GTP-binding protein RhoD", "gene_name": "Rhod", "organism": "Mouse", "refseq_name": "rho-related GTP-binding protein RhoD isoform 1", "refseq_ac": [ { "id": "NP_031511", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031511", "type": "external" } ], "gene_names_uniprotkb": "Rhod; Arhd; Rhom", "gene_names_refseq": "Arhd; RhoHP1; RhoM; Rhod; Rho", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoD; 3.6.5.2", "protein_names_refseq": "aplysia ras-related homolog D; ras homolog D (RhoD); ras homolog gene family, member D; rho-related GTP-binding protein RhoD isoform 1; rho-related GTP-binding protein RhoD", "tax_id": 10090, "disease": "ulcerative colitis (Disease Ontology:DOID:8577)", "pathway": " (mmu:11854)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;23087206;23454120;24102721;34114565;8945468;9395237", "class_list": "", "function": "Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09104", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0042995 cell projection", "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0016477 cell migration;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P97348-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62746-1", "uniprot_id": [ { "id": "RHOB_MOUSE", "url": "https://www.uniprot.org/uniprot/P62746", "type": "external" } ], "mass": 22123.0, "length": 196, "protein_name": "Rho-related GTP-binding protein RhoB", "gene_name": "Rhob", "organism": "Mouse", "refseq_name": "rho-related GTP-binding protein RhoB", "refseq_ac": [ { "id": "NP_031509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031509", "type": "external" } ], "gene_names_uniprotkb": "Rhob; Arhb", "gene_names_refseq": "Arh6; Arhb; Rhob", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoB; 3.6.5.2", "protein_names_refseq": "aplysia ras-related homolog B; ras homolog B; ras homolog gene family, member AB; ras homolog gene family, member B; rho-related GTP-binding protein RhoB", "tax_id": 10090, "disease": "peroxisomal biogenesis disorder (Disease Ontology:DOID:0080377); neurodegenerative disease (Disease Ontology:DOID:1289); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); ulcerative colitis (Disease Ontology:DOID:8577)", "pathway": " (mmu:11852); (R-MMU-114604); (R-MMU-416482); (R-MMU-416572); (R-MMU-5625740); (R-MMU-5625900); (R-MMU-5627117); (R-MMU-5663220); (R-MMU-9013026)", "pathway_count": 9, "publication_count": 14, "publication_id_list": "11353846;11564874;13679852;14597666;15543229;18034455;26495903;31306658;34428180;34557203;35819450;7559652;8662891;8831676", "class_list": "", "function": "Identified the promotion effect of Dicer1 on liver regeneration by increasing miR-21 expression, which inhibits the expression of two negative cell proliferation regulators, Pten and Rhob, [RefSeq, PubMed]; Impaired microtubule dynamics contribute to microthrombocytopenia in RhoB-deficient mice., [RefSeq, PubMed]; Integrated Analysis of Prognostic Genes Associated With Ischemia-Reperfusion Injury in Renal Transplantation. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P01121;Q9CUV7", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0006886 intracellular protein transport;GO:0007015 actin filament organization;GO:0007155 cell adhesion;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P62746-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V0F0-1", "uniprot_id": [ { "id": "RIMB3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V0F0", "type": "external" } ], "mass": 177278.0, "length": 1606, "protein_name": "RIMS-binding protein 3", "gene_name": "Rimbp3", "organism": "Mouse", "refseq_name": "RIMS-binding protein 3", "refseq_ac": [ { "id": "NP_001028510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028510", "type": "external" } ], "gene_names_uniprotkb": "Rimbp3; Gm603; Kiaa1666", "gene_names_refseq": "Gm1759; Gm603; RIM-BP3; Rimbp3; mKIAA1666", "protein_names_uniprotkb": "RIMS-binding protein 3; RIM-BP3", "protein_names_refseq": "RIMS-binding protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:239731)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19091768;21183079;28003339;34418053;35820727", "class_list": "", "function": "Component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development (PubMed:19091768, PubMed:28003339). Important for male fertility (PubMed:19091768)., [UniProtKB, PubMed, PubMed]; RIM-BP3 plays an essential role in manchette development and function through its interaction with Hook1., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B9EJ89;E9PZY2;Q5DTW0", "ec_number_list": [], "go_molecular_function": "GO:0030156 benzodiazepine receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005856 cytoskeleton", "go_biological_process": "GO:0009566 fertilization;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3V0F0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SSM3-1", "uniprot_id": [ { "id": "RHG44_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SSM3", "type": "external" } ], "mass": 88994.0, "length": 814, "protein_name": "Rho GTPase-activating protein 44", "gene_name": "Arhgap44", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 44 isoform 1", "refseq_ac": [ { "id": "NP_001092758", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092758", "type": "external" } ], "gene_names_uniprotkb": "Arhgap44; Rich2", "gene_names_refseq": "6330543G20; Arhgap44; Rich2", "protein_names_uniprotkb": "Rho GTPase-activating protein 44; RICH-2; Rho-type GTPase-activating protein RICH2; RhoGAP interacting with CIP4 homologs protein 2", "protein_names_refseq": "Rho GTPase-activating protein RICH2; Rho-type GTPase-activating protein RICH2; RhoGAP interacting with CIP4 homologs protein 2; rho GTPase-activating protein 44 isoform 1; rho GTPase-activating protein 44", "tax_id": 10090, "disease": "lung carcinoma (Disease Ontology:DOID:3905); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); hepatocellular carcinoma (Disease Ontology:DOID:684); skin melanoma (Disease Ontology:DOID:8923)", "pathway": " (mmu:216831); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11431473;21183079;21750661;23739967;24352656;26969129;31219806;33300544;35820727;37926169", "class_list": "", "function": "GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:24352656, PubMed:26969129). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (PubMed:23739967, PubMed:24352656, PubMed:26969129). Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (By similarity). In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (PubMed:23739967)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Knock-down of Rich2 or disruption of Rich2-Shank3 complex, inhibits dendritic spine enlargement., [RefSeq, PubMed]; RICH2 decreases the mitochondrial number and affects mitochondrial localization in diffuse low-grade glioma-related epilepsy., [RefSeq, PubMed]; RICH2 knockout animals display a selective and highly significant fear of novel objects and increased stereotypic behavior as well as impairment of motor learning. Publication Status: Online-Only, [RefSeq, PubMed]; Shows that the RhoGAP domain of the human RICH2 ortholog can catalyze GTP hydrolysis of both Rac1 and Cdc42, but not of RhoA., [RefSeq, PubMed]; These results suggested that Rich2 controls dendritic spine morphogenesis and function via inhibition of Rac1., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q5SSM4;Q5SSM6;Q5SSM7;Q7TNB9;Q8BW90", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005543 phospholipid binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030425 dendrite;GO:0043197 dendritic spine", "go_biological_process": "GO:0007165 signal transduction;GO:0032956 regulation of actin cytoskeleton organization;GO:0043087 regulation of GTPase activity;GO:0050804 modulation of chemical synaptic transmission;GO:0061001 regulation of dendritic spine morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q5SSM3-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWR8-1", "uniprot_id": [ { "id": "RHPN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWR8", "type": "external" } ], "mass": 76957.0, "length": 686, "protein_name": "Rhophilin-2", "gene_name": "Rhpn2", "organism": "Mouse", "refseq_name": "rhophilin-2", "refseq_ac": [ { "id": "NP_082173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082173", "type": "external" } ], "gene_names_uniprotkb": "Rhpn2", "gene_names_refseq": "1300002E07Rik; D7Ertd784e; Rhpn2", "protein_names_uniprotkb": "Rhophilin-2; GTP-Rho-binding protein 2", "protein_names_refseq": "GTP-Rho-binding protein 2; rhophilin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:52428); (R-MMU-5666185); (R-MMU-8980692); (R-MMU-9013026)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "15767687;17242355;21183079;34428180;36210710", "class_list": "", "function": "Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity (By similarity)., [UniProtKB]; Mice lacking rhophilin 2 develop normally, have normal life spans, and are fertile; rhophilin 2 does not play an essential role in thyroid physiology, [RefSeq, PubMed]; [RHPN2 is highly expressed in osteosarcoma cells to promote cell proliferation and migration and inhibit apoptosis]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DBN2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0003094 glomerular filtration;GO:0051497 negative regulation of stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BWR8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VE91-4", "uniprot_id": [ { "id": "RETR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VE91", "type": "external" } ], "mass": 52967.0, "length": 480, "protein_name": "Reticulophagy regulator 1", "gene_name": "Retreg1", "organism": "Mouse", "refseq_name": "reticulophagy regulator 1 isoform 1", "refseq_ac": [ { "id": "NP_001030023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030023", "type": "external" } ], "gene_names_uniprotkb": "Retreg1; Fam134b", "gene_names_refseq": "1810015C04Rik; Fam134b; Retreg1d; Retreg1", "protein_names_uniprotkb": "Reticulophagy regulator 1; Reticulophagy receptor 1", "protein_names_refseq": "family with sequence similarity 134, member B; protein FAM134B; reticulophagy receptor 1; reticulophagy receptor Fam134b; reticulophagy regulator 1 isoform 1", "tax_id": 10090, "disease": "hereditary sensory and autonomic neuropathy type 2B (Disease Ontology:DOID:0070150)", "pathway": " (mmu:66270)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;19838196;21183079;26040720;27511895;31219806;31930741;34338405;34428180;36302074;37805802;39039299", "class_list": "", "function": "Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes (PubMed:26040720, PubMed:34338405). Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins (PubMed:26040720, PubMed:34338405). Active under basal conditions (By similarity). Required for collagen quality control in a LIR motif-dependent manner (PubMed:34338405). Required for long-term survival of nociceptive and autonomic ganglion neurons (PubMed:19838196, PubMed:26040720)., [UniProtKB, PubMed, PubMed, UniProtKB]; FAM134B-dependent endoplasmic reticulum (ER)-phagy is an important limiting event in Ebola virus (EBOV) replication in mouse cells, [RefSeq, PubMed]; Fam134c and Fam134b shape axonal endoplasmic reticulum architecture in vivo., [RefSeq, PubMed]; Identification of sensory dysfunction and nervous structure changes in Fam134b knockout mice., [RefSeq, PubMed]; Selective endoplasmic reticulum (ER)-phagy via FAM134 proteins is indispensable for mammalian cell homeostasis and controls ER morphology and turnover in mice and humans, [RefSeq, PubMed]; Show that loss-of-function mutations in FAM134B, encoding a newly identified cis-Golgi protein, cause hereditary sensory and autonomic neuropathy type II., [RefSeq, PubMed]; [Influence of family with sequence similarity 134, member B-mediated reticulophagy on lipopolysaccharide-induced apoptosis of mouse dendritic cells]., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QPM1;Q7TMY5;Q9CUJ4;Q9D8Z5", "ec_number_list": [], "go_molecular_function": "GO:0140506 endoplasmic reticulum-autophagosome adaptor activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016604 nuclear body;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0050872 white fat cell differentiation;GO:0019233 sensory perception of pain;GO:0043524 negative regulation of neuron apoptotic process;GO:0006914 autophagy;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8VE91-4", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQV4-1", "uniprot_id": [ { "id": "RETR3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQV4", "type": "external" } ], "mass": 51638.0, "length": 466, "protein_name": "Reticulophagy regulator 3", "gene_name": "Retreg3", "organism": "Mouse", "refseq_name": "reticulophagy regulator 3 isoform 1", "refseq_ac": [ { "id": "NP_080777", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080777", "type": "external" } ], "gene_names_uniprotkb": "Retreg3; Fam134c", "gene_names_refseq": "1300010M03Rik; 4933404C01Rik; Fam134c; Retreg3", "protein_names_uniprotkb": "Reticulophagy regulator 3", "protein_names_refseq": "family with sequence similarity 134, member C; protein FAM134C; reticulophagy regulator 3 isoform 1; reticulophagy regulator 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:67998)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19838196;20173027;21183079;25605945;34338405;34428180;39039299", "class_list": "", "function": "Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes (By similarity). Required for collagen quality control in a LIR motif-dependent manner (PubMed:34338405). Mediates NRF1-enhanced neurite outgrowth (By similarity)., [UniProtKB, UniProtKB, PubMed]; Fam134c and Fam134b shape axonal endoplasmic reticulum architecture in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQL8;Q3U9Q7;Q8BQC4;Q922X3", "ec_number_list": [], "go_molecular_function": "GO:0140506 endoplasmic reticulum-autophagosome adaptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0032991 protein-containing complex;GO:0071782 endoplasmic reticulum tubular network", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0010976 positive regulation of neuron projection development;GO:0030574 collagen catabolic process;GO:0061709 reticulophagy;GO:0007029 endoplasmic reticulum organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CQV4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBX1-1", "uniprot_id": [ { "id": "RGCC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBX1", "type": "external" } ], "mass": 14717.0, "length": 137, "protein_name": "Regulator of cell cycle RGCC", "gene_name": "Rgcc", "organism": "Mouse", "refseq_name": "regulator of cell cycle RGCC", "refseq_ac": [ { "id": "NP_079703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079703", "type": "external" } ], "gene_names_uniprotkb": "Rgcc; Rgc32", "gene_names_refseq": "1190002H23Rik; Rgc-32; Rgc32; Rgcc", "protein_names_uniprotkb": "Regulator of cell cycle RGCC; RGC-32; Response gene to complement 32 protein", "protein_names_refseq": "regulator of cell cycle RGCC; response gene to complement 32 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:66214)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11687586;21183079;21613609;21990365;38279451;38878807", "class_list": "", "function": "Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation., [UniProtKB, PubMed]; RGC-32 as a novel fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation., [RefSeq, PubMed]; RGC-32 facilitates pancreatic cancer via activating Wnt/beta-catenin signaling. Publication Status: Online-Only, [RefSeq, PubMed]; RGC-32 mediates proinflammatory and profibrotic pathways in immune-mediated kidney disease., [RefSeq, PubMed]; Smad2 and PEA3 regulate RGC-32 transcription which is essential for smooth muscle cell differentiation from neural crest cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D0U0", "ec_number_list": [], "go_molecular_function": "GO:0019209 kinase activator activity;GO:0019901 protein kinase binding;GO:0030295 protein kinase activator activity;GO:0019887 protein kinase regulator activity;GO:0070412 R-SMAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007179 transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9DBX1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97352-1", "uniprot_id": [ { "id": "S10AD_MOUSE", "url": "https://www.uniprot.org/uniprot/P97352", "type": "external" } ], "mass": 11158.0, "length": 98, "protein_name": "Protein S100-A13", "gene_name": "S100a13", "organism": "Mouse", "refseq_name": "protein S100-A13", "refseq_ac": [ { "id": "NP_001397457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001397457", "type": "external" } ], "gene_names_uniprotkb": "S100a13", "gene_names_refseq": "S100a13", "protein_names_uniprotkb": "Protein S100-A13; S100 calcium-binding protein A13", "protein_names_refseq": "protein S100-A13", "tax_id": 10090, "disease": "", "pathway": " (mmu:20196)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11432880;12135982;12746488;17991455;19233122;21183079;21750661;26740625;34428180;8878558", "class_list": "", "function": "Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050786 RAGE receptor binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0032730 positive regulation of interleukin-1 alpha production;GO:0015031 protein transport;GO:0001819 positive regulation of cytokine production;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P97352-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55012-1", "uniprot_id": [ { "id": "S12A2_MOUSE", "url": "https://www.uniprot.org/uniprot/P55012", "type": "external" } ], "mass": 131034.0, "length": 1205, "protein_name": "Solute carrier family 12 member 2", "gene_name": "Slc12a2", "organism": "Mouse", "refseq_name": "solute carrier family 12 member 2", "refseq_ac": [ { "id": "NP_033220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033220", "type": "external" } ], "gene_names_uniprotkb": "Slc12a2; Nkcc1", "gene_names_refseq": "9330166H04Rik; BSC2; Nkcc1; Slc12a2; mBSC2; mNKCC1; sy-ns", "protein_names_uniprotkb": "Solute carrier family 12 member 2; BSC2; Basolateral Na-K-Cl symporter; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; Na-K-2Cl cotransporter 1; mNKCC1", "protein_names_refseq": "Na-K-2Cl cotransporter 1; basolateral Na-K-Cl symporter; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; sodium/potassium/chloride cotransporters; sodium/potassium/chloride transporters; solute carrier family 12 member 2", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 78 (Disease Ontology:DOID:0112159); sensorineural hearing loss (Disease Ontology:DOID:10003); hypertension (Disease Ontology:DOID:10763); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (mmu:20496); (R-MMU-426117)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;14563843;16382158;19144319;19656770;21183079;21750661;21972418;26495903;30084848;31599954;32294086;32658972;34428180;36306358;37828378;7929272", "class_list": "", "function": "Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:14563843, PubMed:32658972, PubMed:36306358). Plays a vital role in the regulation of ionic balance and cell volume (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9452, "biomarker_type": "", "glycan_count": 3, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9PYU3", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0051087 protein-folding chaperone binding;GO:0051879 Hsp90 protein binding;GO:0008519 ammonium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0043025 neuronal cell body;GO:0016324 apical plasma membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:1990869 cellular response to chemokine;GO:0030644 intracellular chloride ion homeostasis;GO:0061044 negative regulation of vascular wound healing;GO:0070634 transepithelial ammonium transport;GO:0050910 detection of mechanical stimulus involved in sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P55012-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1000000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28571-3", "uniprot_id": [ { "id": "SC6A9_MOUSE", "url": "https://www.uniprot.org/uniprot/P28571", "type": "external" } ], "mass": 76544.0, "length": 692, "protein_name": "Sodium- and chloride-dependent glycine transporter 1", "gene_name": "Slc6a9", "organism": "Mouse", "refseq_name": "sodium- and chloride-dependent glycine transporter 1 isoform 1", "refseq_ac": [ { "id": "NP_032161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032161", "type": "external" } ], "gene_names_uniprotkb": "Slc6a9; Glyt1", "gene_names_refseq": "Glyt-1; Glyt1; Slc6a9", "protein_names_uniprotkb": "Sodium- and chloride-dependent glycine transporter 1; GlyT-1; GlyT1; Solute carrier family 6 member 9", "protein_names_refseq": "sodium- and chloride-dependent glycine transporter 1 isoform 1; sodium- and chloride-dependent glycine transporter 1; solute carrier family 6 member 9", "tax_id": 10090, "disease": "idiopathic scoliosis (Disease Ontology:DOID:0060250); glycine encephalopathy (Disease Ontology:DOID:9268)", "pathway": " (mmu:14664); (R-MMU-442660)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;14622582;1618338;21183079;24566201;25428506;27773429;30084848;31219806;41018975;7891186;8226790", "class_list": "", "function": "Sodium- and chloride-dependent glycine transporter which is essential for regulating glycine concentrations at inhibitory glycinergic synapses., [UniProtKB, PubMed]; Sodium- and chloride-dependent glycine transporter., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B1ASI9;Q8VC47", "ec_number_list": [], "go_molecular_function": "GO:0015187 glycine transmembrane transporter activity;GO:0005283 amino acid:sodium symporter activity;GO:0015375 glycine:sodium symporter activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0015816 glycine transport;GO:0046985 positive regulation of hemoglobin biosynthetic process;GO:0035725 sodium ion transmembrane transport;GO:0001504 neurotransmitter uptake;GO:0061537 glycine secretion, neurotransmission", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P28571-3", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2P7-1", "uniprot_id": [ { "id": "S38A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2P7", "type": "external" } ], "mass": 53795.0, "length": 485, "protein_name": "Sodium-coupled neutral amino acid symporter 1", "gene_name": "Slc38a1", "organism": "Mouse", "refseq_name": "sodium-coupled neutral amino acid symporter 1", "refseq_ac": [ { "id": "NP_001159928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159928", "type": "external" } ], "gene_names_uniprotkb": "Slc38a1; Nat2; Snat1", "gene_names_refseq": "Gm32457; NAT2; SNAT1; Slc38a1", "protein_names_uniprotkb": "Sodium-coupled neutral amino acid symporter 1; Amino acid transporter A1; MNat2; N-system amino acid transporter 2; Solute carrier family 38 member 1; System A amino acid transporter 1; System N amino acid transporter 1", "protein_names_refseq": "MNat2; N-system amino acid transporter 2; amino acid transporter A1; sodium-coupled neutral amino acid symporter 1; sodium-coupled neutral amino acid transporter 1; system A amino acid transporter 1; system N amino acid transporter 1", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:105727); (R-MMU-210455); (R-MMU-352230)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "11325958;17179157;21183079;25428506;27655909;31050701;31219806;32668809;34203471;34428180;36210013", "class_list": "", "function": "Slc38a1 Conveys Astroglia-Derived Glutamine into GABAergic Interneurons for Neurotransmitter GABA Synthesis. Publication Status: Online-Only, [RefSeq, PubMed]; Symporter that cotransports short-chain neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:11325958, PubMed:17179157, PubMed:27655909, PubMed:32668809). The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient (PubMed:11325958). Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (PubMed:31050701, PubMed:32668809). May also contributes to amino acid transport in placental trophoblast (By similarity). Regulates synaptic plasticity (PubMed:31050701)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNM1;Q3TQ53;Q6NXZ2;Q8BHI3;Q8BXE2;Q99PR1", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0005298 proline:sodium symporter activity;GO:0015186 L-glutamine transmembrane transporter activity;GO:0005283 amino acid:sodium symporter activity;GO:0015375 glycine:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0048167 regulation of synaptic plasticity;GO:0007565 female pregnancy;GO:0006868 glutamine transport;GO:0015804 neutral amino acid transport;GO:1903803 L-glutamine import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8K2P7-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VEB2-1", "uniprot_id": [ { "id": "SAV1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VEB2", "type": "external" } ], "mass": 44845.0, "length": 386, "protein_name": "Protein salvador homolog 1", "gene_name": "Sav1", "organism": "Mouse", "refseq_name": "protein salvador homolog 1 isoform 1", "refseq_ac": [ { "id": "NP_071311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071311", "type": "external" } ], "gene_names_uniprotkb": "Sav1; Ww45; Wwp3", "gene_names_refseq": "1700040G09Rik; Salv; Sav1; Sav; WW45; Wwp3; Wwp4", "protein_names_uniprotkb": "Protein salvador homolog 1; 45 kDa WW domain protein; mWW45", "protein_names_refseq": "45 kDa WW domain protein; WW domain-containing protein 3; WW domain-containing protein 4; protein salvador homolog 1 isoform 1; protein salvador homolog 1", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); kidney cancer (Disease Ontology:DOID:263); colonic disease (Disease Ontology:DOID:5353); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:64010); (R-MMU-2028269)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11027580;17239860;18369314;20080689;21183079;30084848;31219806;34428180;36828914;37548015;38731829", "class_list": "", "function": "Importance of the filamin A-Sav1 interaction in organ size control: evidence from transgenic mice., [RefSeq, PubMed]; Loss of SAV1 in Kidney Proximal Tubule Induces Maladaptive Repair after Ischemia and Reperfusion Injury. Publication Status: Online-Only, [RefSeq, PubMed]; Mice lacking WW45 reveal a crucial role for WW45 in cell-cycle exit and epithelial terminal differentiation., [RefSeq, PubMed]; N6-Methyladenosine-modified circSAV1 triggers ferroptosis in COPD through recruiting YTHDF1 to facilitate the translation of IREB2., [RefSeq, PubMed]; Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (By similarity)., [UniProtKB, PubMed, PubMed]; Show using a conditional allele of sav1, that an adaptor that potentiates mst1 and mst2 activity is likewise required to suppress growth in the mature liver and to prevent tumor formation., [RefSeq, PubMed]; While typical WW domains function as monomeric modules that recognize proline-rich sequences, by using conserved residues that are solvent-exposed on the surface of the beta-sheet, this WW domain buries these residues in the dimer interface., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D9N9;Q9ER46", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0140537 transcription regulator activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0045600 positive regulation of fat cell differentiation;GO:0006915 apoptotic process;GO:0035329 hippo signaling", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8VEB2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D818-1", "uniprot_id": [ { "id": "SAPC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D818", "type": "external" } ], "mass": 42780.0, "length": 391, "protein_name": "Suppressor APC domain-containing protein 2", "gene_name": "Sapcd2", "organism": "Mouse", "refseq_name": "suppressor APC domain-containing protein 2 isoform a", "refseq_ac": [ { "id": "NP_001074554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074554", "type": "external" } ], "gene_names_uniprotkb": "Sapcd2", "gene_names_refseq": "2010317E24Rik; 6030458L21Rik; Sapcd2; ang", "protein_names_uniprotkb": "Suppressor APC domain-containing protein 2; Protein Ang", "protein_names_refseq": "protein Ang; protein C9orf140 homolog; suppressor APC domain-containing protein 2 isoform a; suppressor APC domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72080)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15567712;25428506;26766442;30084848;30779550;31219806;37453647", "class_list": "", "function": "Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (PubMed:26766442). Negatively regulates the mitotic apical cortex localization of GPSM2 (By similarity). Involved also in positive regulation of cell proliferation and tumor cell growth (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AJ17;Q3TL89;Q3TP90;Q3TQ24;Q6NS42", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0045179 apical cortex;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0000132 establishment of mitotic spindle orientation;GO:0090175 regulation of establishment of planar polarity;GO:0098725 symmetric cell division;GO:1904777 negative regulation of protein localization to cell cortex", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9D818-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ER74-1", "uniprot_id": [ { "id": "SALL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ER74", "type": "external" } ], "mass": 140230.0, "length": 1322, "protein_name": "Sal-like protein 1", "gene_name": "Sall1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sall1; Sal3", "gene_names_refseq": "", "protein_names_uniprotkb": "Sal-like protein 1; Sal-3; Zinc finger protein Spalt-3; mSal-3", "protein_names_refseq": "", "tax_id": 10090, "disease": "Townes-Brocks syndrome (Disease Ontology:DOID:0050887); middle lobe syndrome (Disease Ontology:DOID:2810); carcinoma (Disease Ontology:DOID:305); renal Wilms' tumor (Disease Ontology:DOID:5176); hepatoblastoma (Disease Ontology:DOID:687); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": "", "pathway_count": 0, "publication_count": 12, "publication_id_list": "10965108;11688560;11836251;16545361;19483677;21183079;25428506;30059200;30084848;31219806;36852467;40997131", "class_list": "", "function": "Transcriptional repressor involved in organogenesis (PubMed:11688560, PubMed:11836251). Plays an essential role in ureteric bud invasion during kidney development (PubMed:11688560)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q920R5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000792 heterochromatin;GO:0010369 chromocenter", "go_biological_process": "GO:0061034 olfactory bulb mitral cell layer development;GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0021553 olfactory nerve development;GO:0072092 ureteric bud invasion;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9ER74-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61234-1", "uniprot_id": [ { "id": "SNTA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61234", "type": "external" } ], "mass": 53665.0, "length": 503, "protein_name": "Alpha-1-syntrophin", "gene_name": "Snta1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Snta1; Snt1", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-1-syntrophin; 59 kDa dystrophin-associated protein A1 acidic component 1; Syntrophin-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "long QT syndrome 12 (Disease Ontology:DOID:0110653); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); status epilepticus (Disease Ontology:DOID:1824); long QT syndrome (Disease Ontology:DOID:2843); sudden infant death syndrome (Disease Ontology:DOID:9007); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:20648); (R-MMU-9913351)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10220348;10525145;10893187;10913299;11551227;17242355;18044967;21183079;21750661;22371502;34428180;37507081;39927985;7547961;7691103;8625413;9063877;9214383;9412493", "class_list": "", "function": "Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VEF3", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0051117 ATPase binding;GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0005856 cytoskeleton;GO:0031594 neuromuscular junction;GO:0045211 postsynaptic membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0007528 neuromuscular junction development;GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization;GO:0002027 regulation of heart rate;GO:0086005 ventricular cardiac muscle cell action potential;GO:1902305 regulation of sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q61234-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AS89-1", "uniprot_id": [ { "id": "GDAH_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AS89", "type": "external" } ], "mass": 38255.0, "length": 358, "protein_name": "Guanidino acid hydrolase, mitochondrial", "gene_name": "Agmat", "organism": "Mouse", "refseq_name": "guanidino acid hydrolase, mitochondrial isoform 2 precursor", "refseq_ac": [ { "id": "NP_001074877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074877", "type": "external" } ], "gene_names_uniprotkb": "Agmat; Gdah", "gene_names_refseq": "5033405N08Rik; Agmat", "protein_names_uniprotkb": "Guanidino acid hydrolase, mitochondrial; 3.5.3.-; 3.5.3.17; 3.5.3.1; 3.5.3.7; Arginase, mitochondrial; Guanidinobutyrase, mitochondrial; Guanidinopropionase, mitochondrial", "protein_names_refseq": "AUH; agmatinase, mitochondrial; agmatine ureohydrolase (agmatinase); arginase, mitochondrial; guanidino acid hydrolase, mitochondrial isoform 2 precursor; guanidino acid hydrolase, mitochondrial; guanidinobutyrase, mitochondrial; guanidinopropionase, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:75986); (R-MMU-351143)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11914032;15028567;23576753;23806337;27404284;27846445;34428180", "class_list": "", "function": "Hydrolyzes linear guanidino acids to form urea and the corresponding amines. Displays specificity for substrates having a negatively charged head group and short chains including taurocyamine, guanidino propanoic and butanoic acids. May protect cells by detoxifying potentially harmful amounts of guanidino acids. Metabolizes L-arginine with low efficiency., [UniProtKB, UniProtKB]; It thus appears that mammalian AGMs form a distinct group within the family of ureahydrolases that (i) either fold in a manner distinct from other members in this family, or (ii) require accessory proteins to bind Mn(2+) in a mechanism related to that observed for the Ni(2+)-dependent urease., [RefSeq, PubMed]; These findings implicate Agmat in the depressive-like phenotype of Crtc1(-/-) mice, refine current understanding of the agmatinergic system in the brain and highlight its putative role in major depression. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14BN7", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.5.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.-", "type": "external" }, { "id": "3.5.3.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.17", "type": "external" }, { "id": "3.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.7", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004053 arginase activity;GO:0008783 agmatinase activity;GO:0047971 guanidinobutyrase activity;GO:0047972 guanidinopropionase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0000050 urea cycle;GO:0033389 putrescine biosynthetic process from arginine, via agmatine", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A2AS89-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WE1-1", "uniprot_id": [ { "id": "SNX15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WE1", "type": "external" } ], "mass": 37742.0, "length": 337, "protein_name": "Sorting nexin-15", "gene_name": "Snx15", "organism": "Mouse", "refseq_name": "sorting nexin-15", "refseq_ac": [ { "id": "NP_081188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081188", "type": "external" } ], "gene_names_uniprotkb": "Snx15", "gene_names_refseq": "1500032B08Rik; E130013C21Rik; Snx15", "protein_names_uniprotkb": "Sorting nexin-15", "protein_names_refseq": "sorting nexin-15", "tax_id": 10090, "disease": "", "pathway": " (mmu:69024)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;24129315;25428506;26115702;31219806;32848054;34428180", "class_list": "", "function": "May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; SNX15 regulates the recycling of APP to cell surface and, thus, its processing for Abeta generation. Erratum:[Mol Neurobiol. 2023 Jan;60(1):428-429. doi: 10.1007/s12035-022-03097-7. PMID: 36322338], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91WE1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UU41-1", "uniprot_id": [ { "id": "SCIMP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UU41", "type": "external" } ], "mass": 17140.0, "length": 150, "protein_name": "SLP adapter and CSK-interacting membrane protein", "gene_name": "Scimp", "organism": "Mouse", "refseq_name": "SLP adapter and CSK-interacting membrane protein", "refseq_ac": [ { "id": "NP_001038991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038991", "type": "external" } ], "gene_names_uniprotkb": "Scimp; A430084P05Rik", "gene_names_refseq": "A430084P05Rik; Scimp", "protein_names_uniprotkb": "SLP adapter and CSK-interacting membrane protein", "protein_names_refseq": "SLP adapter and CSK-interacting membrane protein; transmembrane protein C17orf87 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:327957)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19144319;21750661;21930792;26495903;27288407;28098138;28290451;34428180;35201640;35337798", "class_list": "", "function": "An alternative downstream translation start site in the non-TIR adaptor Scimp enables selective amplification of CpG DNA responses in mouse macrophages., [RefSeq, PubMed]; In macrophages, SCIMP is constitutively associated with the Lyn tyrosine kinase, is required for tyrosine phosphorylation of TLR4, and facilitates TLR-inducible production of the IL-6 and IL-12p40. Publication Status: Online-Only, [RefSeq, PubMed]; Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells (PubMed:27288407, PubMed:28098138, PubMed:28290451). It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation (By similarity). In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans (PubMed:27288407). It also acts as an agonist-inducible signaling adapter for TLR1, TLR2, TLR3, TLR4, and TLR7 by selectively enabling the expression of pro-inflammatory cytokines IL6 and IL12B in macrophages and acting as a scaffold for phosphorylation of Toll-like receptors by Src-family kinases (PubMed:28098138)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; SCIMP is strongly phosphorylated after Dectin-1 stimulation and that it participates in signal transduction downstream of this important pattern recognition receptor., [RefSeq, PubMed]; The transmembrane adapter SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RVG2;Q5SX69", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0043235 receptor complex;GO:0097197 tetraspanin-enriched microdomain;GO:0030175 filopodium;GO:0045335 phagocytic vesicle", "go_biological_process": "GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0032755 positive regulation of interleukin-6 production;GO:0002720 positive regulation of cytokine production involved in immune response;GO:0034142 toll-like receptor 4 signaling pathway;GO:0034154 toll-like receptor 7 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3UU41-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09671-1", "uniprot_id": [ { "id": "SODM_MOUSE", "url": "https://www.uniprot.org/uniprot/P09671", "type": "external" } ], "mass": 24603.0, "length": 222, "protein_name": "Superoxide dismutase [Mn], mitochondrial", "gene_name": "Sod2", "organism": "Mouse", "refseq_name": "superoxide dismutase [Mn], mitochondrial precursor", "refseq_ac": [ { "id": "NP_038699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038699", "type": "external" } ], "gene_names_uniprotkb": "Sod2; Sod-2", "gene_names_refseq": "MnSOD; Sod-2; Sod2", "protein_names_uniprotkb": "Superoxide dismutase [Mn], mitochondrial; 1.15.1.1", "protein_names_refseq": "manganese SOD; manganese superoxide dismutase; superoxide dismutase [Mn], mitochondrial precursor; superoxide dismutase [Mn], mitochondrial", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); sensorineural hearing loss (Disease Ontology:DOID:10003); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); urinary bladder cancer (Disease Ontology:DOID:11054); adult respiratory distress syndrome (Disease Ontology:DOID:11394); osteoporosis (Disease Ontology:DOID:11476); diabetic angiopathy (Disease Ontology:DOID:11713); nephrotic syndrome (Disease Ontology:DOID:1184); optic neuritis (Disease Ontology:DOID:1210); primary biliary cholangitis (Disease Ontology:DOID:12236); vitiligo (Disease Ontology:DOID:12306); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); exfoliation syndrome (Disease Ontology:DOID:13641); polyneuropathy (Disease Ontology:DOID:1389); bladder neck obstruction (Disease Ontology:DOID:13948); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); Parkinson's disease (Disease Ontology:DOID:14330); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); hypothyroidism (Disease Ontology:DOID:1459); urticaria (Disease Ontology:DOID:1555); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); melanoma (Disease Ontology:DOID:1909); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); bilirubin metabolic disorder (Disease Ontology:DOID:2741); asthma (Disease Ontology:DOID:2841); carotid artery disease (Disease Ontology:DOID:3407); inclusion body myositis (Disease Ontology:DOID:3429); Canavan disease (Disease Ontology:DOID:3613); Leigh disease (Disease Ontology:DOID:3652); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); brain edema (Disease Ontology:DOID:4724); esophagus adenocarcinoma (Disease Ontology:DOID:4914); liver cirrhosis (Disease Ontology:DOID:5082); intestinal disease (Disease Ontology:DOID:5295); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); reactive arthritis (Disease Ontology:DOID:6196); hepatocellular carcinoma (Disease Ontology:DOID:684); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); abdominal aortic aneurysm (Disease Ontology:DOID:7693); infectious mononucleosis (Disease Ontology:DOID:8568); mycosis fungoides (Disease Ontology:DOID:8691); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); hyperhomocysteinemia (Disease Ontology:DOID:9279); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:20656); (R-MMU-2151201); (R-MMU-3299685)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;20668652;21172655;21750661;23576753;23806337;26495903;27930699;28011936;34428180;36288343;37453647;37507081;3797253;39927985;7613035;7875582;8406027", "class_list": "", "function": "Destroys radicals which are normally produced within the cells and which are toxic to biological systems., [UniProtKB, UniProtKB]; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 64, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q64670;Q8VEM5", "ec_number_list": [ { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-", "type": "external" }, { "id": "1.14.12.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.12.-", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.1", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0019899 enzyme binding;GO:0030145 manganese ion binding;GO:0042802 identical protein binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0048773 erythrophore differentiation;GO:0034021 response to silicon dioxide;GO:1902631 negative regulation of membrane hyperpolarization;GO:0000303 response to superoxide;GO:0010729 positive regulation of hydrogen peroxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P09671-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56726-1", "uniprot_id": [ { "id": "SMO_MOUSE", "url": "https://www.uniprot.org/uniprot/P56726", "type": "external" } ], "mass": 87450.0, "length": 793, "protein_name": "Protein smoothened", "gene_name": "Smo", "organism": "Mouse", "refseq_name": "protein smoothened precursor", "refseq_ac": [ { "id": "NP_795970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_795970", "type": "external" } ], "gene_names_uniprotkb": "Smo; Smoh", "gene_names_refseq": "E130215L21Rik; Smoh; Smo; bnb; smoothened", "protein_names_uniprotkb": "Protein smoothened", "protein_names_refseq": "bent body; protein smoothened precursor; protein smoothened; smoothened homolog", "tax_id": 10090, "disease": "primary bacterial infectious disease (Disease Ontology:DOID:0050338); medulloblastoma (Disease Ontology:DOID:0050902); pre-malignant neoplasm (Disease Ontology:DOID:0060071); stomach cancer (Disease Ontology:DOID:10534); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); nevoid basal cell carcinoma syndrome (Disease Ontology:DOID:2512); basal cell carcinoma (Disease Ontology:DOID:2513); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus adenocarcinoma (Disease Ontology:DOID:4914); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); gastric papillary adenocarcinoma (Disease Ontology:DOID:5593); gastric tubular adenocarcinoma (Disease Ontology:DOID:6595); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); malignant pleural mesothelioma (Disease Ontology:DOID:7474); Barrett's esophagus (Disease Ontology:DOID:9206); colorectal cancer (Disease Ontology:DOID:9256); ocular hypertension (Disease Ontology:DOID:9282); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:319757); (R-MMU-5610787); (R-MMU-5620922); (R-MMU-5632684); (R-MMU-5635838)", "pathway_count": 5, "publication_count": 32, "publication_id_list": "10.1101/2023.09.13.557529;11517919;15618519;16136078;16707575;16885213;17199044;17200122;17641202;18497258;19464178;21659505;22072986;22231273;23332756;23831757;23954590;24171105;25644602;27437577;27545348;27705744;28344083;29804838;30340023;31263273;31657721;33886552;35658032;37828378;39138140;9196051", "class_list": "", "function": "G protein-coupled receptor, which transduces the smoothened signaling pathway (PubMed:16707575, PubMed:16885213, PubMed:17200122, PubMed:22231273, PubMed:23954590, PubMed:25644602, PubMed:27437577, PubMed:27545348, PubMed:27705744, PubMed:29804838, PubMed:30340023, PubMed:31263273, PubMed:31657721, PubMed:33886552). Activated by cholesterol in response to hedgehog (DHH, IHH or SHH) morphogens (PubMed:16707575, PubMed:17200122, PubMed:22231273, PubMed:23954590, PubMed:27437577, PubMed:27545348, PubMed:27705744, PubMed:29804838, PubMed:31657721). In absence of hedgehog, SMO is inactivated by patched protein (PTCH1 or PTCH2), which prevents SMO access to cholesterol (PubMed:17641202, PubMed:31657721). In response to hedgehog-binding to pathched, inhibition is relieved, promoting SMO translocation to primary cilium and activation by cholesterol: cholesterol causes a conformation change that triggers signaling via G protein G(i), mediating inhibition of adenylate cyclase activity and decreassed production of cAMP (PubMed:16885213). Decreased cAMP levels then inhibit protein kinase A (PKA) and promote release of GLI (GLI1, GLI2 and GLI3) transcription factors, which activate expression of target genes (By similarity). Active SMO also directly inhibits PKA by sequestering its catalytic subunit, PRKACA, at the cell membrane, preventing PRKACA-mediated phosphorylation and subsequent processing of GLI transcription factors (PubMed:33886552, PubMed:39138140). Active SMO also promotes the removal of GPR161, a key inhibitor of the smoothened signaling pathway, from primary cilia (PubMed:23332756)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 48, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9562, "biomarker_type": "", "glycan_count": 2, "disease_count": 22, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0008142 oxysterol binding;GO:0004930 G protein-coupled receptor activity;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0005113 patched binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0060242 contact inhibition;GO:0001708 cell fate specification;GO:0045880 positive regulation of smoothened signaling pathway;GO:0003140 determination of left/right asymmetry in lateral mesoderm", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "P56726-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97496-1", "uniprot_id": [ { "id": "SMRC1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97496", "type": "external" } ], "mass": 122890.0, "length": 1104, "protein_name": "SWI/SNF complex subunit SMARCC1", "gene_name": "Smarcc1", "organism": "Mouse", "refseq_name": "SWI/SNF complex subunit SMARCC1 isoform 1", "refseq_ac": [ { "id": "NP_033237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033237", "type": "external" } ], "gene_names_uniprotkb": "Smarcc1; Baf155; Srg3", "gene_names_refseq": "BAF155; Rsc8; SRG3; Smarcc1; msp3", "protein_names_uniprotkb": "SWI/SNF complex subunit SMARCC1; BAF155; BRG1-associated factor 155; SWI/SNF complex 155 kDa subunit; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1; SWI3-related protein", "protein_names_refseq": "BRG1-associated factor 155; SWI/SNF complex 155 kDa subunit; SWI/SNF complex subunit SMARCC1 isoform 1; SWI/SNF complex subunit SMARCC1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1; SWI3-related protein", "tax_id": 10090, "disease": "opportunistic bacterial infectious disease (Disease Ontology:DOID:0050340); colorectal carcinoma (Disease Ontology:DOID:0080199); hydrocephalus (Disease Ontology:DOID:10908); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); Coffin-Siris syndrome (Disease Ontology:DOID:1925); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:20588); (R-MMU-3214858); (R-MMU-8939243); (R-MMU-9933937); (R-MMU-9933939); (R-MMU-9933946); (R-MMU-9933947); (R-MMU-9934037)", "pathway_count": 8, "publication_count": 17, "publication_id_list": "11604513;17640523;19131326;20111005;21095589;21183079;21750661;22952240;23806337;24129315;26601204;29374058;34428180;37805104;39088321;39627609;9151708", "class_list": "", "function": "Baf155 controls hematopoietic differentiation and regeneration through chromatin priming., [RefSeq, PubMed]; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The BAF chromatin complex component SMARCC1 does not mediate GLI transcriptional repression of Hedgehog target genes in limb buds., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q7TS80;Q7TT29", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016514 SWI/SNF complex;GO:0071564 npBAF complex", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:2000819 regulation of nucleotide-excision repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P97496-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PE01-1", "uniprot_id": [ { "id": "SNR40_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PE01", "type": "external" } ], "mass": 39276.0, "length": 358, "protein_name": "U5 small nuclear ribonucleoprotein 40 kDa protein", "gene_name": "Snrnp40", "organism": "Mouse", "refseq_name": "U5 small nuclear ribonucleoprotein 40 kDa protein", "refseq_ac": [ { "id": "NP_079921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079921", "type": "external" } ], "gene_names_uniprotkb": "Snrnp40; Wdr57", "gene_names_refseq": "0610009C03Rik; Prp8bp; Snrnp40; Wdr57", "protein_names_uniprotkb": "U5 small nuclear ribonucleoprotein 40 kDa protein; U5 snRNP 40 kDa protein; WD repeat-containing protein 57", "protein_names_refseq": "U5 small nuclear ribonucleoprotein 40 kDa protein; U5 snRNP 40 kDa protein; U5 snRNP-specific protein (Prp8-binding); WD repeat domain 57 (U5 snRNP specific); WD repeat-containing protein 57; small nuclear ribonucleoprotein 40kDa (U5)", "tax_id": 10090, "disease": "", "pathway": " (mmu:66585); (R-MMU-72163); (R-MMU-72165)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;24129315;28011936;31219806;31427773;34428180;36210013", "class_list": "", "function": "Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity)., [UniProtKB, UniProtKB]; These studies report a new immunodeficiency disorder in mice caused by a viable hypomorphic mutation of Snrnp40, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEJ3;Q9DCX3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0000375 RNA splicing, via transesterification reactions;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6PE01-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VI67-1", "uniprot_id": [ { "id": "SP7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VI67", "type": "external" } ], "mass": 44718.0, "length": 428, "protein_name": "Transcription factor Sp7", "gene_name": "Sp7", "organism": "Mouse", "refseq_name": "transcription factor Sp7 isoform 2", "refseq_ac": [ { "id": "NP_001335134", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001335134", "type": "external" } ], "gene_names_uniprotkb": "Sp7; Osx", "gene_names_refseq": "6430578P22Rik; C22; Osx; Sp7", "protein_names_uniprotkb": "Transcription factor Sp7; C22; Zinc finger protein osterix", "protein_names_refseq": "transcription factor Sp7 isoform 2; transcription factor Sp7; zinc finger protein osterix", "tax_id": 10090, "disease": "osteogenesis imperfecta type 12 (Disease Ontology:DOID:0110348); aortic valve stenosis (Disease Ontology:DOID:1712)", "pathway": " (mmu:170574)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11792318;12647290;17510056;19927124;20682789;29187734;30026585;39800889", "class_list": "", "function": "Osterix gene was expressed in rib cartilage-derived chondrocytes and BMP-2 treatment enhanced this expression, [RefSeq, PubMed]; Transcriptional activator essential for osteoblast differentiation (PubMed:11792318, PubMed:17510056, PubMed:30026585). Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (PubMed:11792318, PubMed:17510056)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C5R3;Q8C6A7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0071344 diphosphate metabolic process;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060218 hematopoietic stem cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8VI67-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPS8-1", "uniprot_id": [ { "id": "SMAKA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPS8", "type": "external" } ], "mass": 11926.0, "length": 106, "protein_name": "A-kinase anchoring protein 19", "gene_name": "Akap19", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Akap19", "gene_names_refseq": "", "protein_names_uniprotkb": "A-kinase anchoring protein 19; Small membrane A-kinase anchor protein; Small membrane AKAP; smAKAP", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:67080)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;23115245", "class_list": "", "function": "Binds to type I regulatory subunits of protein kinase A (PKA-RI) and anchors/targets them to the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034237 protein kinase A regulatory subunit binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CPS8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CW03-1", "uniprot_id": [ { "id": "SMC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CW03", "type": "external" } ], "mass": 141556.0, "length": 1217, "protein_name": "Structural maintenance of chromosomes protein 3", "gene_name": "Smc3", "organism": "Mouse", "refseq_name": "structural maintenance of chromosomes protein 3", "refseq_ac": [ { "id": "NP_031816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031816", "type": "external" } ], "gene_names_uniprotkb": "Smc3; Bam; Bmh; Cspg6; Mmip1; Smc3l1; Smcd", "gene_names_refseq": "Bamacan; Cspg6; HCAP; Mmip1; SMC-3; Smc3; SmcD", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein 3; Bamacan; Basement membrane-associated chondroitin proteoglycan; Chondroitin sulfate proteoglycan 6; Chromosome segregation protein SmcD; Mad member-interacting protein 1; SMC protein 3; SMC-3", "protein_names_refseq": "SMC protein 3; basement membrane-associated chondroitin proteoglycan; chondroitin sulfate proteoglycan 6; chromosome segregation protein SmcD; mad member-interacting protein 1; structural maintenace of chromosomes 3; structural maintenance of chromosomes protein 3", "tax_id": 10090, "disease": "Cornelia de Lange syndrome 3 (Disease Ontology:DOID:0080507); intellectual disability (Disease Ontology:DOID:1059); Cornelia de Lange syndrome (Disease Ontology:DOID:11725); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:13006); (R-MMU-2467813); (R-MMU-2468052); (R-MMU-2470946); (R-MMU-2500257); (R-MMU-3108214)", "pathway_count": 6, "publication_count": 18, "publication_id_list": "10358101;10375619;11483963;11564881;15378723;17525332;21183079;22346761;23806337;24287868;31219806;34203471;34428180;34887587;35820727;36210013;39627609;9528857", "class_list": "glycogene", "function": "Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 33, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35667;Q9QUS3", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0046982 protein heterodimerization activity;GO:0016887 ATP hydrolysis activity;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0030892 mitotic cohesin complex;GO:0030893 meiotic cohesin complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0006281 DNA repair;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0006275 regulation of DNA replication;GO:0019827 stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9CW03-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D826-1", "uniprot_id": [ { "id": "SOX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D826", "type": "external" } ], "mass": 43847.0, "length": 390, "protein_name": "Peroxisomal sarcosine oxidase", "gene_name": "Pipox", "organism": "Mouse", "refseq_name": "peroxisomal sarcosine oxidase", "refseq_ac": [ { "id": "NP_032978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032978", "type": "external" } ], "gene_names_uniprotkb": "Pipox; Pso", "gene_names_refseq": "LPIPOX; Pipox; Pso", "protein_names_uniprotkb": "Peroxisomal sarcosine oxidase; 1.5.3.1; 1.5.3.7; L-pipecolate oxidase; L-pipecolic acid oxidase; PSO", "protein_names_refseq": "L-pipecolate oxidase; L-pipecolic acid oxidase; peroxisomal sarcosine oxidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:19193); (R-MMU-71064); (R-MMU-9033241)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "23576753;25428506;30084848;34428180;37453647;9441754", "class_list": "", "function": "Metabolizes sarcosine, L-pipecolic acid and L-proline., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O55223", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0008115 sarcosine oxidase activity;GO:0050031 L-pipecolate oxidase activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0033514 L-lysine catabolic process to acetyl-CoA via L-pipecolate", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D826-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P9Z1-1", "uniprot_id": [ { "id": "SMRD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P9Z1", "type": "external" } ], "mass": 54986.0, "length": 483, "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3", "gene_name": "Smarcd3", "organism": "Mouse", "refseq_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3", "refseq_ac": [ { "id": "NP_080167", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080167", "type": "external" } ], "gene_names_uniprotkb": "Smarcd3; Baf60c", "gene_names_refseq": "1500001J14Rik; 2210409C08Rik; BAF60C; Smarcd3", "protein_names_uniprotkb": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3; 60 kDa BRG-1/Brm-associated factor subunit C; BAF60C; BRG1-associated factor 60C; mBAF60c", "protein_names_refseq": "60 kDa BRG-1/Brm-associated factor subunit C; BRG1-associated factor 60C; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3; mBAF60c", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); Coffin-Siris syndrome (Disease Ontology:DOID:1925)", "pathway": " (mmu:66993); (R-MMU-3214858); (R-MMU-400206); (R-MMU-8939243); (R-MMU-9707564); (R-MMU-9933939); (R-MMU-9933946); (R-MMU-9933947); (R-MMU-9934037)", "pathway_count": 9, "publication_count": 9, "publication_id_list": "14701856;17640523;21750661;22952240;26601204;29374058;34887587;36653361;37284884", "class_list": "", "function": "Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:22952240, PubMed:26601204). Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Myofiber Baf60c controls muscle regeneration by modulating Dkk3-mediated paracrine signaling., [RefSeq, PubMed]; Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q921D3;Q9CX89;Q9DB99", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0005102 signaling receptor binding;GO:0003712 transcription coregulator activity;GO:0016922 nuclear receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016514 SWI/SNF complex;GO:0071564 npBAF complex", "go_biological_process": "GO:2000819 regulation of nucleotide-excision repair;GO:0003407 neural retina development;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6P9Z1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X939-1", "uniprot_id": [ { "id": "SL9A3_MOUSE", "url": "https://www.uniprot.org/uniprot/G3X939", "type": "external" } ], "mass": 93104.0, "length": 829, "protein_name": "Sodium/hydrogen exchanger 3", "gene_name": "Slc9a3", "organism": "Mouse", "refseq_name": "sodium/hydrogen exchanger 3 precursor", "refseq_ac": [ { "id": "NP_001074529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074529", "type": "external" } ], "gene_names_uniprotkb": "Slc9a3", "gene_names_refseq": "9030624O13Rik; NHE-3; NHE3; Slc9a3", "protein_names_uniprotkb": "Sodium/hydrogen exchanger 3", "protein_names_refseq": "sodium/hydrogen exchanger 3 precursor; sodium/hydrogen exchanger 3", "tax_id": 10090, "disease": "sleep apnea (Disease Ontology:DOID:0050847); left ventricular failure (Disease Ontology:DOID:0051064); congenital secretory sodium diarrhea 8 (Disease Ontology:DOID:0060777); hypertension (Disease Ontology:DOID:10763); exocrine pancreatic insufficiency (Disease Ontology:DOID:13316); malignant renovascular hypertension (Disease Ontology:DOID:13730); cystic fibrosis (Disease Ontology:DOID:1485); renovascular hypertension (Disease Ontology:DOID:1591); nephrolithiasis (Disease Ontology:DOID:585); gastrointestinal system disease (Disease Ontology:DOID:77); chronic kidney disease (Disease Ontology:DOID:784); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:105243); (R-MMU-425986)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21183079;21750661;31219806;34428180;37682076;38533975;9662405", "class_list": "", "function": "CGMP-dependent kinase 2, Na[+]/H[+] exchanger NHE3, and PDZ-adaptor NHERF2 co-assemble in apical membrane microdomains., [RefSeq, PubMed]; Megalin is involved in angiotensinogen-induced, angiotensin II-mediated ERK1/2 signaling to activate Na + -H + exchanger 3 in proximal tubules., [RefSeq, PubMed]; Plasma membrane Na(+)/H(+) antiporter. Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis (By similarity). Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation (PubMed:9662405)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZU0", "ec_number_list": [], "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0015386 potassium:proton antiporter activity;GO:0042802 identical protein binding;GO:0030165 PDZ domain binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0070062 extracellular exosome;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0002028 regulation of sodium ion transport;GO:0006883 intracellular sodium ion homeostasis;GO:0006898 receptor-mediated endocytosis;GO:0006814 sodium ion transport;GO:0051453 regulation of intracellular pH", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "G3X939-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UH99-1", "uniprot_id": [ { "id": "SHSA6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UH99", "type": "external" } ], "mass": 58426.0, "length": 525, "protein_name": "Protein shisa-6", "gene_name": "Shisa6", "organism": "Mouse", "refseq_name": "protein shisa-6 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001030046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030046", "type": "external" } ], "gene_names_uniprotkb": "Shisa6; Gm879", "gene_names_refseq": "Gm879; Shisa6; ckamp52", "protein_names_uniprotkb": "Protein shisa-6; CKAMP52; Cystine-knot AMPAR modulating protein of 52 kDa; Shisa family member 6", "protein_names_refseq": "cysteine-knot AMPAR-modulating protein 52; cystine-knot AMPAR modulating protein of 52 kDa; protein shisa-6 homolog; protein shisa-6 isoform 2 precursor; shisa homolog 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:380702)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;16452087;21183079;21750661;25428506;26623514;26931375;28196692;32294428;32848054;35820727", "class_list": "", "function": "AMPAR Auxiliary Protein SHISA6 Facilitates Purkinje Cell Synaptic Excitability and Procedural Memory Formation., [RefSeq, PubMed]; Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (PubMed:26931375). May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway (PubMed:28196692)., [UniProtKB, PubMed, PubMed]; Shisa6 prevents synaptically trapped AMPARs from depression at high-frequency synaptic transmission. Publication Status: Online-Only, [RefSeq, PubMed]; This study indicates that AMPAR function is very precisely controlled by the cell-type specific expression of the CKAMP family members 39, 52 and 59. Erratum:[Elife. 2018 Oct 11;7:e42543. doi: 10.7554/eLife.42543. PMID: 30306889] Publication Status: Online-Only, [RefSeq, PubMed]; This study proposes a generic mechanism of stem cell regulation in a facultative (or open) niche environment, with which different levels of a cell-autonomous inhibitor (SHISA6, in this case) generates heterogeneous resistance to widely distributed differentiation-promoting extracellular signaling, such as WNTs., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0A172Q417", "ec_number_list": [], "go_molecular_function": "GO:0030165 PDZ domain binding;GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0014069 postsynaptic density;GO:0045211 postsynaptic membrane;GO:0032281 AMPA glutamate receptor complex;GO:0032591 dendritic spine membrane", "go_biological_process": "GO:1904717 regulation of AMPA glutamate receptor clustering;GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0098976 excitatory chemical synaptic transmission;GO:0007283 spermatogenesis;GO:0090090 negative regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q3UH99-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60879-1", "uniprot_id": [ { "id": "SNP25_MOUSE", "url": "https://www.uniprot.org/uniprot/P60879", "type": "external" } ], "mass": 23315.0, "length": 206, "protein_name": "Synaptosomal-associated protein 25", "gene_name": "Snap25", "organism": "Mouse", "refseq_name": "synaptosomal-associated protein 25 isoform b", "refseq_ac": [ { "id": "NP_001277985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277985", "type": "external" } ], "gene_names_uniprotkb": "Snap25; Snap", "gene_names_refseq": "Bdr; GENA70; SNAP-25; SUP; Snap25; sp", "protein_names_uniprotkb": "Synaptosomal-associated protein 25; SNAP-25; SUP; Super protein; Synaptosomal-associated 25 kDa protein", "protein_names_refseq": "blind drunk; super protein; synaptosomal-associated 25 kDa protein; synaptosomal-associated protein 25 isoform b; synaptosomal-associated protein, 25 kDa", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 117 (Disease Ontology:DOID:0110683); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Down syndrome (Disease Ontology:DOID:14250); epilepsy (Disease Ontology:DOID:1826); schizophrenia (Disease Ontology:DOID:5419); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:20614)", "pathway_count": 1, "publication_count": 33, "publication_id_list": "10195194;10413679;11471062;12459461;15466855;16672379;17055430;19196426;19285662;19546860;20798282;20847230;21183079;21949876;22645316;22832103;23341457;23376809;24374286;25253725;2592413;26198635;26406599;27052163;28801590;28821673;29056747;32848054;35309682;8103915;8243676;9349529;9731768", "class_list": "", "function": "t-SNARE involved in the molecular regulation of neurotransmitter release (PubMed:8103915, PubMed:8243676). May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF (PubMed:16672379). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AIC2;A2AIC3;P13795;P36974;P70557;P70558;Q8IXK3;Q96FM2;Q9BR45", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0048306 calcium-dependent protein binding;GO:0044325 transmembrane transporter binding;GO:0008289 lipid binding;GO:0017022 myosin binding", "go_cellular_component": "GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex;GO:0098978 glutamatergic synapse;GO:0098888 extrinsic component of presynaptic membrane;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:1903296 positive regulation of glutamate secretion, neurotransmission;GO:0007626 locomotory behavior;GO:0008306 associative learning;GO:0016197 endosomal transport;GO:0031340 positive regulation of vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P60879-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PHU5-1", "uniprot_id": [ { "id": "SORT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PHU5", "type": "external" } ], "mass": 91200.0, "length": 825, "protein_name": "Sortilin", "gene_name": "Sort1", "organism": "Mouse", "refseq_name": "sortilin isoform 1 precursor", "refseq_ac": [ { "id": "NP_001258528", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258528", "type": "external" } ], "gene_names_uniprotkb": "Sort1", "gene_names_refseq": "2900053A11Rik; Ntr3; Ntsr3; Sort1", "protein_names_uniprotkb": "Sortilin; NTR3; Neurotensin receptor 3; mNTR3", "protein_names_refseq": "mNTR3; neurotensin receptor 3; sortilin isoform 1 precursor", "tax_id": 10090, "disease": "abdominal aortic aneurysm (Disease Ontology:DOID:7693)", "pathway": " (mmu:20661); (R-MMU-432722)", "pathway_count": 2, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;10064893;10085125;10594043;11322955;15236332;15236333;15372498;15992544;16075062;17242355;19407813;21102451;21183079;26495903;26740625;30084848;30779550;30899004;34203471;35820727;38337131;38493927;9452485", "class_list": "", "function": "Contribution of ApoB-100/SORT1-Mediated Immune Microenvironment in Regulating Oxidative Stress, Inflammation, and Ferroptosis After Spinal Cord Injury., [RefSeq, PubMed]; Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Sortilin in Biliary Epithelial Cells Promotes Ductular Reaction and Fibrosis during Cholestatic Injury., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 9, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A2AEE8;Q3UHE2;Q8K043;Q9QXW6", "ec_number_list": [], "go_molecular_function": "GO:0048406 nerve growth factor binding;GO:0019899 enzyme binding;GO:0030379 neurotensin receptor activity, non-G protein-coupled;GO:0010465 nerve growth factor receptor activity;GO:1905394 retromer complex binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit", "go_biological_process": "GO:0006897 endocytosis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0008333 endosome to lysosome transport;GO:0032868 response to insulin", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "Q6PHU5-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1B0GSZ0-1", "uniprot_id": [ { "id": "SPAR_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1B0GSZ0", "type": "external" } ], "mass": 8470.0, "length": 75, "protein_name": "Small regulatory polypeptide of amino acid response", "gene_name": "Spaar", "organism": "Mouse", "refseq_name": "small regulatory polypeptide of amino acid response", "refseq_ac": [ { "id": "NP_001335037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001335037", "type": "external" } ], "gene_names_uniprotkb": "Spaar; Spar", "gene_names_refseq": "5430416O09Rik; Spaar; Spar", "protein_names_uniprotkb": "Small regulatory polypeptide of amino acid response", "protein_names_refseq": "small regulatory polypeptide of amino acid response", "tax_id": 10090, "disease": "", "pathway": " (mmu:71406)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "28024296;31990292;33478078", "class_list": "", "function": "Data provide a mechanism by which mTORC1 activation may be finely regulated in a tissue-specific manner in response to injury, and a paradigm by which lncRNAs encoding small polypeptides like SPAR can modulate general biological pathways and processes to facilitate tissue-specific requirements, consistent with their restricted and highly regulated expression profile, [RefSeq, PubMed]; Negative regulator of amino acid sensing and mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels and amino acids (By similarity). Negatively regulates mTORC1 activation by inhibiting recruitment of mTORC1 to lysosomes upon stimulation with amino acids: acts by promoting the formation of a tightly bound supercomplex composed of the lysosomal V-ATPase, Ragulator and Rag GTPases, preventing recruitment of mTORC1 (By similarity). Acts as a regulator of muscle regeneration following injury by regulating mTORC1 activation (PubMed:28024296)., [UniProtKB, PubMed, UniProtKB]; The Influence of the LINC00961/SPAAR Locus Loss on Murine Development, Myocardial Dynamics, and Cardiac Response to Myocardial Infarction. Publication Status: Online-Only, [RefSeq, PubMed]; The LINC00961 transcript and its encoded micropeptide, small regulatory polypeptide of amino acid response, regulate endothelial cell function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0046611 lysosomal proton-transporting V-type ATPase complex", "go_biological_process": "GO:0071230 cellular response to amino acid stimulus;GO:0043416 regulation of skeletal muscle tissue regeneration;GO:1904262 negative regulation of TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A1B0GSZ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGD4-1", "uniprot_id": [ { "id": "SO4C1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGD4", "type": "external" } ], "mass": 78412.0, "length": 722, "protein_name": "Solute carrier organic anion transporter family member 4C1", "gene_name": "Slco4c1", "organism": "Mouse", "refseq_name": "solute carrier organic anion transporter family member 4C1", "refseq_ac": [ { "id": "NP_766246", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766246", "type": "external" } ], "gene_names_uniprotkb": "Slco4c1; Oatp4c1; Slc21a20", "gene_names_refseq": "9530051F04; C330017E21Rik; OATP-H; OATP-M1; OATP4C1; OATPX; PRO2176; SLC21A20; Slco4c1; oatp-R", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member 4C1; OATP4C1; Oatp-R; Organic anion transporting polypeptide 4C1; Slco4c1; Solute carrier family 21 member 20", "protein_names_refseq": "organic anion transporting polypeptide 4C1; solute carrier family 21 member 20; solute carrier organic anion transporter family member 4C1", "tax_id": 10090, "disease": "kidney failure (Disease Ontology:DOID:1074)", "pathway": " (mmu:227394); (R-MMU-6798695); (R-MMU-879518)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "16641146;21183079;34428180;35820727;39145457", "class_list": "", "function": "Mediates the transport of organic anions such as steroids (estrone 3-sulfate, chenodeoxycholate, glycocholate) and thyroid hormones (3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4)), in the kidney. Capable of transporting cAMP and pharmacological substances such as digoxin, ouabain and methotrexate. Transport is independent of sodium, chloride ion, and ATP. Transport activity is stimulated by an acidic extracellular environment due to increased substrate affinity to the transporter (By similarity). The driving force for this transport activity is currently not known (By similarity). The role of hydrogencarbonate (HCO3(-), bicarbonate) as the probable counteranion that exchanges for organic anions is still not well defined (By similarity). Functions as an uptake transporter at the apical membrane, suggesting a role in renal reabsorption (By similarity). Involved in the renal secretion of the uremic toxin ADMA (N(omega),N(omega)-dimethyl-L-arginine or asymmetrical dimethylarginine), which is associated to cardiovascular events and mortality, and the structurally related amino acids L-arginine and L-homoarginine (a cardioprotective biomarker). Can act bidirectionally, suggesting a dual protective role of this transport protein; exporting L-homoarginine after being synthesized in proximal tubule cells, and mediating uptake of ADMA from the blood into proximal tubule cells where it is degraded by the enzyme dimethylarginine dimethylaminohydrolase 1 (DDAH1) (By similarity). May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells (PubMed:16641146). This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation (PubMed:16641146). May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg (PubMed:16641146)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0015711 organic anion transport;GO:0043252 sodium-independent organic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BGD4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2S4-1", "uniprot_id": [ { "id": "SPAC7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2S4", "type": "external" } ], "mass": 19943.0, "length": 182, "protein_name": "Sperm acrosome-associated protein 7", "gene_name": "Spaca7", "organism": "Mouse", "refseq_name": "sperm acrosome-associated protein 7 isoform 1 precursor", "refseq_ac": [ { "id": "NP_077241", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077241", "type": "external" } ], "gene_names_uniprotkb": "Spaca7", "gene_names_refseq": "1700094C09Rik; Spaca7", "protein_names_uniprotkb": "Sperm acrosome-associated protein 7", "protein_names_refseq": "protein SPACA7; sperm acrosome-associated protein 7 isoform 1 precursor; sperm acrosome-associated protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:78634)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;22495889;24307706", "class_list": "", "function": "Confocal microscopy studies revealed an intra-acrosomal not membrane-bound localization of SPACA7/EGFP, which suggests that the protein can be released during acrosome reaction and involved in fertilization., [RefSeq, PubMed]; Involved in fertilization. Does not seem to play a direct role in sperm-egg binding or gamete fusion., [UniProtKB, PubMed]; Release of SPACA7 from the acrosome accelerates cumulus dispersal and facilitates fertilization via unknown mechanisms. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0001669 acrosomal vesicle;GO:0043160 acrosomal lumen", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D2S4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923A2-1", "uniprot_id": [ { "id": "SPDLY_MOUSE", "url": "https://www.uniprot.org/uniprot/Q923A2", "type": "external" } ], "mass": 70237.0, "length": 608, "protein_name": "Protein Spindly", "gene_name": "Spdl1", "organism": "Mouse", "refseq_name": "protein Spindly", "refseq_ac": [ { "id": "NP_081687", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081687", "type": "external" } ], "gene_names_uniprotkb": "Spdl1; Ccdc99", "gene_names_refseq": "1700018I02Rik; 2600001J17Rik; 2810049B11Rik; Ccdc99; Spdl1", "protein_names_uniprotkb": "Protein Spindly; Coiled-coil domain-containing protein 99; Spindle apparatus coiled-coil domain-containing protein 1", "protein_names_refseq": "coiled-coil domain containing 99; coiled-coil domain-containing protein 99; protein Spindly; spindle apparatus coiled-coil domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70385); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 8, "publication_count": 6, "publication_id_list": "19144319;20505367;21183079;25428506;31219806;31690663", "class_list": "", "function": "Overexpression of mSpindly failed to enhance inactivation of SAC and acceleration of the meiotic process., [RefSeq, PubMed]; Required for the localization of dynein and dynactin to the mitotic kinetochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Plays a role in cell migration (By similarity)., [UniProtKB, HAMAP, UniProtKB]; Spdl1 expression is significantly down-regulated in Mrtfb knockout mouse intestine., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5DY45", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0043515 kinetochore binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0000940 outer kinetochore", "go_biological_process": "GO:0016477 cell migration;GO:0051301 cell division;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0007080 mitotic metaphase chromosome alignment;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q923A2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLZ8-1", "uniprot_id": [ { "id": "SIGIR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLZ8", "type": "external" } ], "mass": 46159.0, "length": 409, "protein_name": "Single Ig IL-1-related receptor", "gene_name": "Sigirr", "organism": "Mouse", "refseq_name": "single Ig IL-1-related receptor isoform 1", "refseq_ac": [ { "id": "NP_075546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075546", "type": "external" } ], "gene_names_uniprotkb": "Sigirr; Tir8", "gene_names_refseq": "Sigirr; TIR8", "protein_names_uniprotkb": "Single Ig IL-1-related receptor; Single Ig IL-1R-related molecule; Single immunoglobulin domain-containing IL1R-related protein; TIR8; Toll/interleukin-1 receptor 8", "protein_names_refseq": "single Ig IL-1 receptor related protein; single Ig IL-1-related receptor isoform 1; single Ig IL-1-related receptor; single Ig IL-1R-related molecule; single Ig IL-1R-related protein; single immunoglobulin domain-containing IL1R-related protein; toll/interleukin-1 receptor 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:24058)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10346978;12925853;14993616;16785552;17242355;17398123;21077278;21183079;21750661;29187734;35046386;36527283", "class_list": "", "function": "Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity)., [UniProtKB, PubMed]; Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]; Regulation of CD18 stability by SIGIRR-modulated ubiquitination: new insights into the relationship between innate immune response and acute lung injury., [RefSeq, PubMed]; SIGIRR is critical in resistance to Pseudomonas aeruginosa corneal infection by down-regulating type 1 immunity and negative regulation of IL-1 and TLR4 signaling., [RefSeq, PubMed]; TIR8 represents a negative pathway of regulation of the IL-1 receptor/TLR system, expressed in epithelial cells and DC, crucial for tuning inflammation in the gastrointestinal tract., [RefSeq, PubMed]; Theses results indicate that epithelium-derived SIGIRR is critical in controlling the homeostasis and innate immune responses of the colon to enteric microflora., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q52L48", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0001960 negative regulation of cytokine-mediated signaling pathway;GO:2000660 negative regulation of interleukin-1-mediated signaling pathway;GO:0007166 cell surface receptor signaling pathway;GO:0006953 acute-phase response;GO:0032682 negative regulation of chemokine production", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9JLZ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61152-1", "uniprot_id": [ { "id": "PTN18_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61152", "type": "external" } ], "mass": 50202.0, "length": 453, "protein_name": "Tyrosine-protein phosphatase non-receptor type 18", "gene_name": "Ptpn18", "organism": "Mouse", "refseq_name": "tyrosine-protein phosphatase non-receptor type 18 isoform 1", "refseq_ac": [ { "id": "NP_035336", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035336", "type": "external" } ], "gene_names_uniprotkb": "Ptpn18; Flp1; Ptpk1", "gene_names_refseq": "FLP-1; FLP1; HSCF; PTP-HSCF; PTP-K1; Ptpk1; Ptpn18", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 18; 3.1.3.48; FLP-1; Fetal liver phosphatase 1; PTP-K1", "protein_names_refseq": "fetal liver phosphatase 1; tyrosine-protein phosphatase non-receptor type 18 isoform 1; tyrosine-protein phosphatase non-receptor type 18", "tax_id": 10090, "disease": "", "pathway": " (mmu:19253); (R-MMU-8863795)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "11158295;14660651;17947660;19144319;21750661;25605945;26495903;30084848;30779550;34428180;35820727;8695832;8875997;8977243;9265651", "class_list": "", "function": "BDP1 has a role in negative regulation of HER2 signaling, [RefSeq, PubMed]; May be involved in growth and differentiation of hematopoietic cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4JFH4;Q62404;Q922E3", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0004726 non-membrane spanning protein tyrosine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0001825 blastocyst formation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q61152-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BVQ5-1", "uniprot_id": [ { "id": "PPME1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BVQ5", "type": "external" } ], "mass": 42256.0, "length": 386, "protein_name": "Protein phosphatase methylesterase 1", "gene_name": "Ppme1", "organism": "Mouse", "refseq_name": "protein phosphatase methylesterase 1", "refseq_ac": [ { "id": "NP_082568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082568", "type": "external" } ], "gene_names_uniprotkb": "Ppme1; Pme1", "gene_names_refseq": "1110069N17Rik; 2700017M01Rik; PME-1; Pme1; Ppme1", "protein_names_uniprotkb": "Protein phosphatase methylesterase 1; 3.1.1.89; PME-1", "protein_names_refseq": "protein phosphatase methylesterase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72590); (R-MMU-69273)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10318862;18596935;21044074;21398589;21750661;24129315;28135057;32341098;34769281;37507081;38043157", "class_list": "", "function": "Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors., [RefSeq, PubMed]; Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity)., [UniProtKB]; Hyperphosphorylation of Tau Due to the Interference of Protein Phosphatase Methylesterase-1 Overexpression by MiR-125b-5p in Melatonin Receptor Knockout Mice. Publication Status: Online-Only, [RefSeq, PubMed]; PME-1 plays a critical role in differentiation of neuroblastoma cells., [RefSeq, PubMed]; Reduced Expression of the PP2A Methylesterase, PME-1, or the PP2A Methyltransferase, LCMT-1, Alters Sensitivity to Beta-Amyloid-Induced Cognitive and Electrophysiological Impairments in Mice., [RefSeq, PubMed]; Targeted disruption of the PME-1 gene causes perinatal lethality in mice, a phenotype that correlates with a virtually complete loss of the demethylated form of PP2A in the nervous system and peripheral tissues Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptome analysis revealed that PME-1 suppresses inflammatory signaling, activates PI3K/Akt signaling, and promotes epithelial-mesenchymal transition., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U392;Q3UJX8;Q3UKE0;Q8K311;Q91YR8;Q9CSP7", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.1.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.89", "type": "external" } ], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051721 protein phosphatase 2A binding;GO:0019903 protein phosphatase binding;GO:0004864 protein phosphatase inhibitor activity;GO:0051723 protein methylesterase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BVQ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHL8-1", "uniprot_id": [ { "id": "PSMF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHL8", "type": "external" } ], "mass": 29664.0, "length": 271, "protein_name": "Proteasome inhibitor PI31 subunit", "gene_name": "Psmf1", "organism": "Mouse", "refseq_name": "proteasome inhibitor PI31 subunit isoform 1", "refseq_ac": [ { "id": "NP_997611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997611", "type": "external" } ], "gene_names_uniprotkb": "Psmf1", "gene_names_refseq": "PI31; Psmf1", "protein_names_uniprotkb": "Proteasome inhibitor PI31 subunit", "protein_names_refseq": "proteasome inhibitor PI31 subunit isoform 1; proteasome inhibitor PI31 subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:228769)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12374861;21183079;21750661;24129315;25428506;30084848;31327739;31599954;31754024", "class_list": "", "function": "Inactivation of PI31 in mouse neurons attenuated proteasome movement in axons, indicating this process is conserved. Because mutations affecting PI31 activity are associated with human neurodegenerative diseases, impairment of PI31-mediated axonal transport of proteasomes may contribute to these disorders., [RefSeq, PubMed]; PI31 acts as a selective modulator of the proteasome-mediated steps in MHC class I antigen processing, [RefSeq, PubMed]; Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity)., [UniProtKB]; Study in global and conditional PI31 knockout mouse establishes a critical role for PI31 and protein degradation in the maintenance of neuronal architecture, circuitry, and function. Because mutations that impair PI31 function are thought to cause neurodegenerative diseases in humans, reduced PI31 activity may contribute to age-related neurodegenerative diseases., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C0G9", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0004866 endopeptidase inhibitor activity;GO:0070628 proteasome binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0000502 proteasome complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:1901799 negative regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BHL8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23204-1", "uniprot_id": [ { "id": "PPARA_MOUSE", "url": "https://www.uniprot.org/uniprot/P23204", "type": "external" } ], "mass": 52347.0, "length": 468, "protein_name": "Peroxisome proliferator-activated receptor alpha", "gene_name": "Ppara", "organism": "Mouse", "refseq_name": "peroxisome proliferator-activated receptor alpha", "refseq_ac": [ { "id": "NP_001106889", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106889", "type": "external" } ], "gene_names_uniprotkb": "Ppara; Nr1c1; Ppar", "gene_names_refseq": "4933429D07Rik; Nr1c1; PPAR-alpha; PPARalpha; Ppara; Ppar", "protein_names_uniprotkb": "Peroxisome proliferator-activated receptor alpha; Nuclear receptor subfamily 1 group C member 1; PPAR-alpha", "protein_names_refseq": "nuclear receptor subfamily 1 group C member 1; peroxisome proliferator-activated receptor alpha", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hydrocephalus (Disease Ontology:DOID:10908); morbid obesity (Disease Ontology:DOID:11981); alcoholic hepatitis (Disease Ontology:DOID:12351); cystic fibrosis (Disease Ontology:DOID:1485); alcohol use disorder (Disease Ontology:DOID:1574); lipid metabolism disorder (Disease Ontology:DOID:3146); coronary artery disease (Disease Ontology:DOID:3393); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); periodontitis (Disease Ontology:DOID:824); diabetes mellitus (Disease Ontology:DOID:9351); hypertensive encephalopathy (Disease Ontology:DOID:9427); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:19013); (R-MMU-383280); (R-MMU-400206); (R-MMU-4090294); (R-MMU-9707564)", "pathway_count": 5, "publication_count": 19, "publication_id_list": "10788465;12955147;15312046;16950137;18719582;19646743;20159955;2129546;22289908;27738106;28683290;29331071;30084848;31652604;34428180;7588749;8123021;9325263;9627117", "class_list": "", "function": "Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051525 NFAT protein binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0003707 nuclear steroid receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0016604 nuclear body;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:1903944 negative regulation of hepatocyte apoptotic process;GO:0046209 nitric oxide metabolic process;GO:2001171 positive regulation of ATP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P23204-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36993-1", "uniprot_id": [ { "id": "PPM1B_MOUSE", "url": "https://www.uniprot.org/uniprot/P36993", "type": "external" } ], "mass": 42795.0, "length": 390, "protein_name": "Protein phosphatase 1B", "gene_name": "Ppm1b", "organism": "Mouse", "refseq_name": "protein phosphatase 1B isoform 3", "refseq_ac": [ { "id": "NP_001152969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152969", "type": "external" } ], "gene_names_uniprotkb": "Ppm1b; Pp2c2; Pppm1b", "gene_names_refseq": "PP2CB; Ppm1b", "protein_names_uniprotkb": "Protein phosphatase 1B; 3.1.3.16; PP2C-beta; Protein phosphatase 2C isoform beta", "protein_names_refseq": "PP2C-beta; protein phosphatase 1B isoform 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:19043); (R-MMU-1169408)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10469137;17499977;22645316;22781750;23088624;23320500;25428506;25751141;30084848;37507081;7733667;8038726;8274020", "class_list": "", "function": "Although a non-myristoylated mutation (G2A) of PPM1A and PPM1B prevented membrane association, this relocalization did not likely cause the decreased activity towards AMPKalpha., [RefSeq, PubMed]; Enzyme with a broad specificity. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB., [UniProtKB, PubMed]; Ppm1b negatively regulates necroptosis through dephosphorylating Rip3 in vitro and in vivo., [RefSeq, PubMed]; The phosphatase PPM1B as a novel selective modulator of PPARgamma activity., [RefSeq, PubMed]; These observations suggest that relatively high PP2Cbeta expression is specifically required during the early stages of pre-implantation development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "6.3.2.n3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.n3", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction;GO:0006470 protein dephosphorylation;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0043122 regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P36993-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49769-1", "uniprot_id": [ { "id": "PSN1_MOUSE", "url": "https://www.uniprot.org/uniprot/P49769", "type": "external" } ], "mass": 52640.0, "length": 467, "protein_name": "Presenilin-1", "gene_name": "Psen1", "organism": "Mouse", "refseq_name": "presenilin-1 precursor", "refseq_ac": [ { "id": "NP_001349200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001349200", "type": "external" } ], "gene_names_uniprotkb": "Psen1; Ad3h; Psnl1", "gene_names_refseq": "Ad3h; PS-1; PS1; Psen1; S182", "protein_names_uniprotkb": "Presenilin-1; 3.4.23.-; PS-1; Protein S182", "protein_names_refseq": "presenilin-1 precursor", "tax_id": 10090, "disease": "frontotemporal dementia 1 (Disease Ontology:DOID:0051060); early-onset Parkinson's disease (Disease Ontology:DOID:0060894); Alzheimer's disease 3 (Disease Ontology:DOID:0110042); dilated cardiomyopathy 1U (Disease Ontology:DOID:0110455); Alzheimer's disease (Disease Ontology:DOID:10652); Pick's disease (Disease Ontology:DOID:11870); neurodegenerative disease (Disease Ontology:DOID:1289); dilated cardiomyopathy (Disease Ontology:DOID:12930); hidradenitis suppurativa (Disease Ontology:DOID:2280)", "pathway": " (mmu:19164); (R-MMU-1251985); (R-MMU-193692); (R-MMU-205043); (R-MMU-3928665); (R-MMU-6798695); (R-MMU-9013507); (R-MMU-9017802); (R-MMU-9839383)", "pathway_count": 9, "publication_count": 22, "publication_id_list": "10421573;11226248;11517342;11953314;12834865;15345747;16959576;17242355;17360711;17428795;19144319;19834068;20456003;21183079;28533411;30429473;31219806;32822378;34428180;7596406;9160754;9295283", "class_list": "", "function": "Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:19834068). Requires the presence of the other members of the gamma-secretase complex for protease activity (By similarity). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:10421573, PubMed:11517342). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11226248). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed:11953314). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed:11226248). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (PubMed:10421573, PubMed:12834865, PubMed:9160754). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (PubMed:17428795). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Involved in the regulation of neurite outgrowth (By similarity). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (PubMed:30429473)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91WK6;Q9JLP9", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004175 endopeptidase activity;GO:0005262 calcium channel activity;GO:0051117 ATPase binding;GO:0070851 growth factor receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0002573 myeloid leukocyte differentiation;GO:0001708 cell fate specification;GO:0016080 synaptic vesicle targeting;GO:0000045 autophagosome assembly", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P49769-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FM6-1", "uniprot_id": [ { "id": "PPR29_MOUSE", "url": "https://www.uniprot.org/uniprot/Q68FM6", "type": "external" } ], "mass": 90029.0, "length": 823, "protein_name": "Protein phosphatase 1 regulatory subunit 29", "gene_name": "Elfn2", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 29 precursor", "refseq_ac": [ { "id": "NP_898964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898964", "type": "external" } ], "gene_names_uniprotkb": "Elfn2; Kiaa1904; Lrrc62; Ppp1r29", "gene_names_refseq": "6330514E13; Elfn2; Lrrc62; Ppp1r29", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 29; Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2; Leucine-rich repeat and fibronectin type-III domain-containing protein 6; Leucine-rich repeat-containing protein 62", "protein_names_refseq": "5leucine rich repeat containing 62; extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2; leucine rich repeat containing 62; leucine-rich repeat and fibronectin type-III domain-containing protein 6; leucine-rich repeat-containing protein 62; protein phosphatase 1 regulatory subunit 29 precursor; protein phosphatase 1 regulatory subunit 29", "tax_id": 10090, "disease": "", "pathway": " (mmu:207393)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21183079;30899004;31219806;33300544;34203471;38428819", "class_list": "", "function": "Complex N-glycosylation of mGluR6 is required for trans-synaptic interaction with ELFN adhesion proteins. Erratum:[J Biol Chem. 2024 Oct;300(10):107782. doi: 10.1016/j.jbc.2024.107782. PMID: 39332159], [RefSeq, PubMed]; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 12, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q69Z72;Q8CCW8", "ec_number_list": [], "go_molecular_function": "GO:0004864 protein phosphatase inhibitor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0045184 establishment of protein localization;GO:0099560 synaptic membrane adhesion;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q68FM6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CI94-1", "uniprot_id": [ { "id": "PYGB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CI94", "type": "external" } ], "mass": 96730.0, "length": 843, "protein_name": "Glycogen phosphorylase, brain form", "gene_name": "Pygb", "organism": "Mouse", "refseq_name": "glycogen phosphorylase, brain form", "refseq_ac": [ { "id": "NP_722476", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722476", "type": "external" } ], "gene_names_uniprotkb": "Pygb", "gene_names_refseq": "Pygb", "protein_names_uniprotkb": "Glycogen phosphorylase, brain form; 2.4.1.1", "protein_names_refseq": "glycogen phosphorylase, brain form", "tax_id": 10090, "disease": "glycogen storage disease (Disease Ontology:DOID:2747)", "pathway": " (mmu:110078); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;18034455;21183079;25428506;31599954;33300544;33725478;34428180;35984892;36288343;37507081;37828378;39627609;40684658", "class_list": "glycogene;glycosyltransferase", "function": "Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 48, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8K283", "ec_number_list": [ { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0030246 carbohydrate binding;GO:0008184 glycogen phosphorylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon", "go_biological_process": "GO:0005977 glycogen metabolic process;GO:0005980 glycogen catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8CI94-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99M15-1", "uniprot_id": [ { "id": "PPIP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99M15", "type": "external" } ], "mass": 38948.0, "length": 334, "protein_name": "Proline-serine-threonine phosphatase-interacting protein 2", "gene_name": "Pstpip2", "organism": "Mouse", "refseq_name": "proline-serine-threonine phosphatase-interacting protein 2", "refseq_ac": [ { "id": "NP_038859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038859", "type": "external" } ], "gene_names_uniprotkb": "Pstpip2; Mayp", "gene_names_refseq": "MAYP; Pstpip2; cmo", "protein_names_uniprotkb": "Proline-serine-threonine phosphatase-interacting protein 2; Macrophage actin-associated tyrosine-phosphorylated protein; PEST phosphatase-interacting protein 2; pp37", "protein_names_refseq": "PEST phosphatase-interacting protein 2; macrophage actin-associated tyrosine-phosphorylated protein; pp37; proline-serine-threonine phosphatase-interacting protein 2", "tax_id": 10090, "disease": "chronic recurrent multifocal osteomyelitis (Disease Ontology:DOID:0060645)", "pathway": " (mmu:19201)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17947660;19144319;21750661;34428180;38073114;9804836", "class_list": "", "function": "Binds to F-actin. May be involved in regulation of the actin cytoskeleton., [UniProtKB]; Histone deacetylase-mediated silencing of PSTPIP2 expression contributes to aristolochic acid nephropathy-induced PANoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6GTF6;Q9Z189", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99M15-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZX7-1", "uniprot_id": [ { "id": "PP4P2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZX7", "type": "external" } ], "mass": 28038.0, "length": 257, "protein_name": "Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase", "gene_name": "Pip4p2", "organism": "Mouse", "refseq_name": "type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 1", "refseq_ac": [ { "id": "NP_082540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082540", "type": "external" } ], "gene_names_uniprotkb": "Pip4p2; Tmem55a", "gene_names_refseq": "2610319K07Rik; Pip4p2; Tmem55a", "protein_names_uniprotkb": "Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; 3.1.3.78; PtdIns-4,5-P2 4-Ptase II; Transmembrane protein 55A; Type 2 PtdIns-4,5-P2 4-Ptase", "protein_names_refseq": "ptdIns-4,5-P2 4-Ptase II; transmembrane protein 55A; type 2 PtdIns-4,5-P2 4-Ptase; type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 1; type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; type II phosphatidylinositol 4,5-bisphosphate 4-phosphatase", "tax_id": 10090, "disease": "", "pathway": " (mmu:72519)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17242355;19144319;21183079;29378918", "class_list": "", "function": "Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation (PubMed:29378918)., [UniProtKB, PubMed, UniProtKB]; These results suggest that TMEM55a negatively regulates the phagocytosis of large particles by reducing phagosomal PtdIns(4,5)P2 accumulation during cup formation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.78", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.78", "type": "external" } ], "go_molecular_function": "GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:0050765 negative regulation of phagocytosis;GO:0046856 phosphatidylinositol dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CZX7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46097-1", "uniprot_id": [ { "id": "SYT2_MOUSE", "url": "https://www.uniprot.org/uniprot/P46097", "type": "external" } ], "mass": 47263.0, "length": 422, "protein_name": "Synaptotagmin-2", "gene_name": "Syt2", "organism": "Mouse", "refseq_name": "synaptotagmin-2", "refseq_ac": [ { "id": "NP_033333", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033333", "type": "external" } ], "gene_names_uniprotkb": "Syt2", "gene_names_refseq": "IP4BP; Syt2; mKIAA4194; sytII", "protein_names_uniprotkb": "Synaptotagmin-2; IP4-binding protein; IP4BP; Inositol polyphosphate-binding protein; Synaptotagmin II; SytII", "protein_names_refseq": "IP4-binding protein; inositol polyphosphate-binding protein; synaptotagmin-2", "tax_id": 10090, "disease": "congenital myasthenic syndrome 7 (Disease Ontology:DOID:0110659); congenital myasthenic syndrome (Disease Ontology:DOID:3635); neuromuscular junction disease (Disease Ontology:DOID:439)", "pathway": " (mmu:20980); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;14504267;17167418;18034455;20219474;21183079;21750661;23807078;27052163;7961887", "class_list": "", "function": "(Microbial infection) Receptor for C.botulinum neurotoxin type B (BoNT/B, botB); interaction is improved in the presence of gangliosides (PubMed:14504267). The toxin binds via the vesicular domain (residues 47-60) (PubMed:14504267, PubMed:17167418, PubMed:23807078)., [UniProtKB, PubMed, PubMed, PubMed]; (Microbial infection) Receptor for C.botulinum neurotoxin type G (BoNT/G, botG); gangliosides are not required for (or only very slightly improve) binding to a membrane-anchored receptor fragment (PubMed:20219474). The toxin binds via the vesicular domain (residues 47-55) (PubMed:20219474)., [UniProtKB, PubMed]; Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (PubMed:7961887). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (PubMed:7961887). Plays a role in dendrite formation by melanocytes (By similarity)., [UniProtKB, UniProtKB, PubMed]; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone., [UniProtKB, UniProtKB]; This gene encodes a member of the synaptotagmin protein family. Synaptotagmin proteins are involved in membrane trafficking and are characterized by an N-terminal transmembrane region as well as tandem calcium binding domains. The encoded protein is able to bind inositol polyphosphate and is thought to be involved in synaptic function and neurotransmitter release. [provided by RefSeq, Sep 2017]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0E1", "ec_number_list": [], "go_molecular_function": "GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding;GO:0005509 calcium ion binding;GO:0019905 syntaxin binding;GO:0005544 calcium-dependent phospholipid binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0031594 neuromuscular junction;GO:0030672 synaptic vesicle membrane;GO:0070382 exocytic vesicle", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0030154 cell differentiation;GO:0016192 vesicle-mediated transport;GO:0017158 regulation of calcium ion-dependent exocytosis;GO:2000300 regulation of synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P46097-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DB05-1", "uniprot_id": [ { "id": "SNAA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DB05", "type": "external" } ], "mass": 33190.0, "length": 295, "protein_name": "Alpha-soluble NSF attachment protein", "gene_name": "Napa", "organism": "Mouse", "refseq_name": "alpha-soluble NSF attachment protein", "refseq_ac": [ { "id": "NP_080174", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080174", "type": "external" } ], "gene_names_uniprotkb": "Napa; Snapa", "gene_names_refseq": "1500039N14Rik; Napa; RA81; SNAP-alpha; SNAPA; SNARE; a-SNAP; hyh", "protein_names_uniprotkb": "Alpha-soluble NSF attachment protein; N-ethylmaleimide-sensitive factor attachment protein alpha; SNAP-alpha", "protein_names_refseq": "N-ethylmaleimide-sensitive factor attachment protein alpha; alpha-soluble NSF attachment protein; hydrocephaly with hop gait", "tax_id": 10090, "disease": "temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (mmu:108124); (R-MMU-204005); (R-MMU-432722); (R-MMU-6807878); (R-MMU-6811434); (R-MMU-6811438); (R-MMU-6811440)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "21183079;21750661;26495903;31758001;33300544;33725478;34428180;38395304;9705316", "class_list": "", "function": "Munc18c accelerates SNARE-dependent membrane fusion in the presence of regulatory proteins alpha-SNAP and NSF., [RefSeq, PubMed]; Pleiotropic effects of alpha-SNAP M105I mutation on oocyte biology: ultrastructural and cellular changes that adversely affect female fertility in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Together with GNA12 promotes CDH5 localization to plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543I3", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0019905 syntaxin binding;GO:0000149 SNARE binding;GO:0005483 soluble NSF attachment protein activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0035494 SNARE complex disassembly;GO:0006886 intracellular protein transport;GO:0035249 synaptic transmission, glutamatergic;GO:0007420 brain development;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9DB05-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54941-1", "uniprot_id": [ { "id": "SMCE1_MOUSE", "url": "https://www.uniprot.org/uniprot/O54941", "type": "external" } ], "mass": 46638.0, "length": 411, "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1", "gene_name": "Smarce1", "organism": "Mouse", "refseq_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1", "refseq_ac": [ { "id": "NP_065643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065643", "type": "external" } ], "gene_names_uniprotkb": "Smarce1; Baf57", "gene_names_refseq": "2810417B20Rik; 5830412H02Rik; 9030408N19Rik; Baf27; Smarce1", "protein_names_uniprotkb": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1; BAF57; BRG1-associated factor 57", "protein_names_refseq": "BAF57; BRG1-associated factor 57; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1; SWI/SNF-related matrix-associated actin-dependent regulator chromatin subfamily E member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1", "tax_id": 10090, "disease": "Coffin-Siris syndrome 5 (Disease Ontology:DOID:0112368); candidiasis (Disease Ontology:DOID:1508); meningioma (Disease Ontology:DOID:3565); familial meningioma (Disease Ontology:DOID:4586)", "pathway": " (mmu:57376); (R-MMU-3214858); (R-MMU-8939243); (R-MMU-9933937); (R-MMU-9933939); (R-MMU-9933946); (R-MMU-9934037)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "12110891;12145209;17640523;25605945;31219806;34428180;36210013;9435219", "class_list": "", "function": "Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:12110891). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs) (PubMed:12145209)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BPD9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0016922 nuclear receptor binding;GO:0008080 N-acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0071564 npBAF complex;GO:0016363 nuclear matrix", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:2000819 regulation of nucleotide-excision repair;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O54941-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5V2-1", "uniprot_id": [ { "id": "SOBP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0P5V2", "type": "external" } ], "mass": 91784.0, "length": 864, "protein_name": "Sine oculis-binding protein homolog", "gene_name": "Sobp", "organism": "Mouse", "refseq_name": "sine oculis-binding protein homolog", "refseq_ac": [ { "id": "NP_780616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780616", "type": "external" } ], "gene_names_uniprotkb": "Sobp; Jxc1", "gene_names_refseq": "2900009C16Rik; 5330439J01Rik; JXC1; Sobp; jc", "protein_names_uniprotkb": "Sine oculis-binding protein homolog; Jackson circler protein 1", "protein_names_refseq": "jackson circler protein 1; sine oculis-binding protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:109205)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18579736;21035105;21183079", "class_list": "", "function": "Implicated in development of the cochlea., [UniProtKB, UniProtKB]; In situ RNA expression studies in postnatal mouse brain showed strong expression in the limbic system at the time interval of active synaptogenesis., [RefSeq, PubMed]; These data support a role for Jxc1 in controlling a critical step in cochlear growth, cell fate, and patterning of the organ of Corti., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0032184 SUMO polymer binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007626 locomotory behavior;GO:0042472 inner ear morphogenesis;GO:0050890 cognition;GO:0007605 sensory perception of sound;GO:0048513 animal organ development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q0P5V2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TME2-1", "uniprot_id": [ { "id": "SPAG5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TME2", "type": "external" } ], "mass": 129993.0, "length": 1165, "protein_name": "Sperm-associated antigen 5", "gene_name": "Spag5", "organism": "Mouse", "refseq_name": "sperm-associated antigen 5", "refseq_ac": [ { "id": "NP_059103", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059103", "type": "external" } ], "gene_names_uniprotkb": "Spag5", "gene_names_refseq": "D11Bhm180e; Deepest; MAP126; Mastrin; S17; Spag5", "protein_names_uniprotkb": "Sperm-associated antigen 5; MAP126; Mastrin; Mitotic spindle-associated protein p126", "protein_names_refseq": "astrin; microtubule-associated protein; mitotic spindle-associated protein p126; sperm-associated antigen 5", "tax_id": 10090, "disease": "cervical cancer (Disease Ontology:DOID:4362)", "pathway": " (mmu:54141)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12893248;19806032;21183079;25428506;25605945;29187734;31219806;34428180;36852467;38807081", "class_list": "", "function": "Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2. In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis. May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (By similarity)., [UniProtKB, UniProtKB]; SPAG5 deficiency activates autophagy to reduce atherosclerotic plaque formation in ApoE[-/-] mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B1AQC8;Q8CH61", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005829 cytosol;GO:0035253 ciliary rootlet;GO:0016604 nuclear body", "go_biological_process": "GO:0051294 establishment of spindle orientation;GO:0090235 regulation of metaphase plate congression;GO:1905832 positive regulation of spindle assembly;GO:0007059 chromosome segregation;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q7TME2-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BSD5-1", "uniprot_id": [ { "id": "SHE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BSD5", "type": "external" } ], "mass": 53353.0, "length": 492, "protein_name": "SH2 domain-containing adapter protein E", "gene_name": "She", "organism": "Mouse", "refseq_name": "SH2 domain-containing adapter protein E isoform 1", "refseq_ac": [ { "id": "NP_766118", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766118", "type": "external" } ], "gene_names_uniprotkb": "She", "gene_names_refseq": "9430022A14; She", "protein_names_uniprotkb": "SH2 domain-containing adapter protein E", "protein_names_refseq": "SH2 domain-containing adapter protein E isoform 1; SH2 domain-containing adapter protein E; Src homology 2 domain containing E", "tax_id": 10090, "disease": "", "pathway": " (mmu:214547)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;9315092", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZT0", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BSD5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VH2-1", "uniprot_id": [ { "id": "SNX9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VH2", "type": "external" } ], "mass": 66546.0, "length": 595, "protein_name": "Sorting nexin-9", "gene_name": "Snx9", "organism": "Mouse", "refseq_name": "sorting nexin-9", "refseq_ac": [ { "id": "NP_079940", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079940", "type": "external" } ], "gene_names_uniprotkb": "Snx9", "gene_names_refseq": "2700073N08Rik; SDP1; SH3PX1; Snx9", "protein_names_uniprotkb": "Sorting nexin-9", "protein_names_refseq": "sorting nexin-9", "tax_id": 10090, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:66616); (R-MMU-432722); (R-MMU-8856828)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10531379;15592455;17242355;21183079;23437151;25428506;27655699;34428180", "class_list": "", "function": "Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton (PubMed:23437151). Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate (By similarity)., [UniProtKB, PubMed]; Snx9-deficient mice do not show defects in development as well as auditory function, suggesting that SNX9 is not essential for mice development and hearing, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding;GO:0005545 1-phosphatidylinositol binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0043547 positive regulation of GTPase activity;GO:0051044 positive regulation of membrane protein ectodomain proteolysis;GO:0045860 positive regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q91VH2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P4T1-1", "uniprot_id": [ { "id": "SNX19_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P4T1", "type": "external" } ], "mass": 109808.0, "length": 997, "protein_name": "Sorting nexin-19", "gene_name": "Snx19", "organism": "Mouse", "refseq_name": "sorting nexin-19", "refseq_ac": [ { "id": "NP_083150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083150", "type": "external" } ], "gene_names_uniprotkb": "Snx19; Kiaa0254", "gene_names_refseq": "3526401K03Rik; Snx19; mKIAA0254", "protein_names_uniprotkb": "Sorting nexin-19", "protein_names_refseq": "sorting nexin-19", "tax_id": 10090, "disease": "", "pathway": " (mmu:102607)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;19877062;21750661;24843546;25148684;25428506;25605945;27802388;30779550;34428180;40885482", "class_list": "", "function": "Plays a role in intracellular vesicle trafficking and exocytosis (PubMed:24843546). May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion (PubMed:24843546). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:25148684)., [UniProtKB, PubMed, PubMed]; SNX19 and SNX14 PX domains reveal key differences in spatial control of RGS-PX proteins in cell signaling and trafficking., [RefSeq, PubMed]; The ATDC5-C2ER cell line system can be used for efficient monitoring of chondrogenic differentiation by fluorescence analysis. A novel chondrogenic factor (SNX19) is identified for elucidating the molecular network of chondrogenic differentiation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQ83;Q80U53", "ec_number_list": [], "go_molecular_function": "GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0031901 early endosome membrane", "go_biological_process": "GO:0002062 chondrocyte differentiation;GO:0006887 exocytosis;GO:0030073 insulin secretion;GO:1990502 dense core granule maturation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q6P4T1-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q11204-1", "uniprot_id": [ { "id": "SIA4B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q11204", "type": "external" } ], "mass": 40130.0, "length": 350, "protein_name": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2", "gene_name": "St3gal2", "organism": "Mouse", "refseq_name": "CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 2", "refseq_ac": [ { "id": "NP_033205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033205", "type": "external" } ], "gene_names_uniprotkb": "St3gal2; Siat4b; Siat5", "gene_names_refseq": "ST3GalII; Siat5; St3gal2", "protein_names_uniprotkb": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2; 2.4.3.2; 2.4.3.4; Alpha 2,3-ST 2; Beta-galactoside alpha-2,3-sialyltransferase 2; Gal-NAc6S; Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; Monosialoganglioside sialyltransferase; SIAT4-B; ST3Gal II; ST3GalA.2; ST3GalII; Sialyltransferase 4B", "protein_names_refseq": "CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 2; SIAT4-B; ST3Gal II; ST3GalA.2; alpha 2,3-ST 2; beta-galactoside alpha-2,3-sialyltransferase 2; gal-NAc6S; gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; monosialoganglioside sialyltransferase; sialyltransferase 4B; sialyltransferase 5", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:20444); (R-MMU-2022854); (R-MMU-4085001); (R-MMU-977068); (R-MMU-9840309)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22735313;22872234;25605945;27683310;31219806;32030804;34428180;38139047;39256125;8144500;9184827", "class_list": "glycogene;glycosyltransferase", "function": "A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids (PubMed:8144500, PubMed:9184827). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage. Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8144500, PubMed:9184827). Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration (PubMed:22735313). Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury (PubMed:32030804). Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4 (By similarity). Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser (PubMed:8144500)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; GT1b functions as a novel endogenous agonist of toll-like receptor 2 inducing neuropathic pain., [RefSeq, PubMed]; Regulation of autophagy by ST3GAL2-mediated alpha2-3 sialylated glycosphingolipids in hepatic encephalopathy., [RefSeq, PubMed]; Sialyltransferase Mutations Alter the Expression of Calcium-Binding Interneurons in Mice Neocortex, Hippocampus and Striatum. Publication Status: Online-Only, [RefSeq, PubMed]; T3gal2-null mice display a reduced respiratory exchange ratio compared to WT mice, indicating a preference for lipid oxidation as an energy source. Despite their altered metabolism, St3gal2-null mice were hyperactive. We conclude that altered ganglioside expression in adipose tissue results in diminished IR sensitivity and late-onset obesity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BPL0", "ec_number_list": [ { "id": "2.4.3.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.9", "type": "external" }, { "id": "2.4.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.2", "type": "external" }, { "id": "2.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.4", "type": "external" }, { "id": "2.4.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.6", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0008373 sialyltransferase activity;GO:0047288 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase;GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0016020 membrane;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0001576 globoside biosynthetic process;GO:0009101 glycoprotein biosynthetic process;GO:0009247 glycolipid biosynthetic process;GO:0009312 oligosaccharide biosynthetic process;GO:0097503 sialylation", "synthesized_glycan_count": 412, "hit_score": 1.6, "record_id": "Q11204-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000000.100.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920B9-1", "uniprot_id": [ { "id": "SP16H_MOUSE", "url": "https://www.uniprot.org/uniprot/Q920B9", "type": "external" } ], "mass": 119825.0, "length": 1047, "protein_name": "FACT complex subunit SPT16", "gene_name": "Supt16h; Supt16", "organism": "Mouse", "refseq_name": "FACT complex subunit SPT16", "refseq_ac": [ { "id": "NP_291096", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_291096", "type": "external" } ], "gene_names_uniprotkb": "Supt16h; Supt16; Fact140; Factp140; Supt16h; Supt16", "gene_names_refseq": "Cdc68; Fact140; Spt16; Supt16h; Supt16", "protein_names_uniprotkb": "FACT complex subunit SPT16; Chromatin-specific transcription elongation factor 140 kDa subunit; FACT 140 kDa subunit; FACTp140; Facilitates chromatin transcription complex subunit SPT16", "protein_names_refseq": "FACT 140 kDa subunit; FACT complex subunit SPT16; FACTp140; chromatin-specific transcription elongation factor 140 kDa subunit; facilitates chromatin transcription complex subunit SPT16; suppressor of Ty 16 homolog", "tax_id": 10090, "disease": "neurodevelopmental disorder with dysmorphic facies and thin corpus callosum (Disease Ontology:DOID:0070469)", "pathway": " (mmu:114741); (R-MMU-112382); (R-MMU-674695); (R-MMU-6796648); (R-MMU-6804756); (R-MMU-75955)", "pathway_count": 6, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;11471063;21750661;21952136;23364797;23806337;25428506;25605945;26842758;30084848;30779550;31219806;32894293;34428180;34887587;36226587;37507081;39627609", "class_list": "", "function": "Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; FACT is required for TOP1 binding to H3K4me3 at non-B DNA containing chromatin for the site-specific cleavage. Publication Status: Online-Only, [RefSeq, PubMed]; Histone chaperone FACT represses retrotransposon MERVL and MERVL-derived cryptic promoters., [RefSeq, PubMed]; Supt16 haploinsufficiency causes neurodevelopment disorder by disrupting MAPK pathway in neural stem cells., [RefSeq, PubMed]; The mouse Supt16h/Fact140 gene, encoding part of the FACT chromatin transcription complex, maps close to Tcra and is highly expressed in thymus, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZ48;Q3UFH0;Q921H4", "ec_number_list": [], "go_molecular_function": "GO:0031491 nucleosome binding", "go_cellular_component": "GO:0035101 FACT complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006260 DNA replication;GO:0006334 nucleosome assembly;GO:0006337 nucleosome disassembly", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q920B9-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54751-1", "uniprot_id": [ { "id": "SIA4A_MOUSE", "url": "https://www.uniprot.org/uniprot/P54751", "type": "external" } ], "mass": 39073.0, "length": 337, "protein_name": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1", "gene_name": "St3gal1", "organism": "Mouse", "refseq_name": "CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 1", "refseq_ac": [ { "id": "NP_033203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033203", "type": "external" } ], "gene_names_uniprotkb": "St3gal1; Siat4a; Siat4", "gene_names_refseq": "5330418N22Rik; ST3GalI; Siat4a; Siat4; St3gal-1; St3gal1", "protein_names_uniprotkb": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1; 2.4.3.2; 2.4.3.4; Alpha 2,3-ST 1; Beta-galactoside alpha-2,3-sialyltransferase 1; Gal-NAc6S; Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; Monosialoganglioside sialyltransferase; SIAT4-A; ST3Gal I; ST3GalA.1; ST3GalI; ST3O; Sialyltransferase 4A", "protein_names_refseq": "CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 1; CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase; Gal beta1,3 GalNAc alpha2,3 sialyltransferase; SIAT4-A; ST3GAL-I sialyltransferase; ST3Gal I; ST3GalA.1; ST3O; alpha 2,3-ST 1; beta-galactoside alpha-2,3-sialyltransferase 1; gal-NAc6S; gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; monosialoganglioside sialyltransferase; sialyltransferase 4A (beta-galactosidase alpha-2,3-sialytransferase); sialyltransferase 4A (beta-galactoside alpha-2,3-sialytransferase)", "tax_id": 10090, "disease": "", "pathway": " (mmu:20442); (R-MMU-2022854); (R-MMU-4085001); (R-MMU-977068)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10755614;18250455;34428180;8144500;8375377;9184827", "class_list": "glycogene;glycosyltransferase", "function": "A beta-galactoside alpha2->3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:8375377, PubMed:9184827). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:10755614, PubMed:8144500, PubMed:8375377, PubMed:9184827). Adds sialic acid to the core 1 O-glycan, Galbeta-(1->3)-GalNAc-O-Ser/Thr, which is a major structure of mucin-type O-glycans. As part of a homeostatic mechanism that regulates CD8-positive T cell numbers, sialylates core 1 O-glycans of T cell glycoproteins, SPN/CD43 and PTPRC/CD45. Prevents premature apoptosis of thymic CD8-positive T cells prior to peripheral emigration, whereas in the secondary lymphoid organs controls the survival of CD8-positive memory T cells generated following a successful immune response (PubMed:10755614). Transfers sialic acid to asialofetuin, presumably onto Galbeta-(1->3)-GalNAc-O-Ser (PubMed:8375377). Sialylates GM1a, GA1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8144500, PubMed:8375377, PubMed:9184827)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; St3gal-1 functions to protect CD8 T cells from apoptosis, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 9474, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q11202", "ec_number_list": [ { "id": "2.4.3.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.9", "type": "external" }, { "id": "2.4.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.2", "type": "external" }, { "id": "2.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.4", "type": "external" }, { "id": "2.4.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.6", "type": "external" } ], "go_molecular_function": "GO:0047288 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase;GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane;GO:0032588 trans-Golgi network membrane;GO:1990675 Golgi medial cisterna membrane;GO:1990676 Golgi trans cisterna membrane", "go_biological_process": "GO:0006054 N-acetylneuraminate metabolic process;GO:0006468 protein phosphorylation;GO:0009101 glycoprotein biosynthetic process;GO:0006487 protein N-linked glycosylation;GO:1905403 negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process", "synthesized_glycan_count": 881, "hit_score": 1.2, "record_id": "P54751-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58043-1", "uniprot_id": [ { "id": "SESN2_MOUSE", "url": "https://www.uniprot.org/uniprot/P58043", "type": "external" } ], "mass": 54377.0, "length": 480, "protein_name": "Sestrin-2", "gene_name": "Sesn2", "organism": "Mouse", "refseq_name": "sestrin-2", "refseq_ac": [ { "id": "NP_659156", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659156", "type": "external" } ], "gene_names_uniprotkb": "Sesn2", "gene_names_refseq": "HI95; SEST2; Ses2; Sesn2", "protein_names_uniprotkb": "Sestrin-2; 1.11.1.-", "protein_names_refseq": "sestrin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:230784); (R-MMU-5628897); (R-MMU-9639288); (R-MMU-9755511)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "18344994;18692468;22958918;23274085;24947615;25040165;25259925;25377878;25605945;34428180;39117956", "class_list": "", "function": "Functions as an intracellular leucine sensor that negatively regulates the mTORC1 signaling pathway through the GATOR complex (PubMed:18692468, PubMed:25259925). In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents mTORC1 signaling (PubMed:18692468, PubMed:25259925). Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:18692468, PubMed:25259925). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses (By similarity). May negatively regulate protein translation in response to endoplasmic reticulum stress, via mTORC1 (PubMed:24947615). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468). Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Inhibition of Sesn2 has negative regulatory effects on the myogenic differentiation of C2C12 myoblasts. Publication Status: Online-Only, [RefSeq, PubMed]; Sestrin1 and Sestrin2 therefore provide an important link between genotoxic stress, p53 and the mTOR signaling pathway. Erratum:[Cell. 2009 Jan 23;136(2):378], [RefSeq, PubMed]; Synaptic activity upregulated the thioredoxin-peroxiredoxin reactivating gene sestrin 2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" } ], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0016684 oxidoreductase activity, acting on peroxide as acceptor;GO:0005092 GDP-dissociation inhibitor activity;GO:0032542 sulfiredoxin activity;GO:0042731 PH domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005765 lysosomal membrane;GO:1990316 Atg1/ULK1 kinase complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006635 fatty acid beta-oxidation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0072659 protein localization to plasma membrane;GO:0032147 activation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P58043-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UH53-1", "uniprot_id": [ { "id": "SDK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UH53", "type": "external" } ], "mass": 240306.0, "length": 2193, "protein_name": "Protein sidekick-1", "gene_name": "Sdk1", "organism": "Mouse", "refseq_name": "protein sidekick-1", "refseq_ac": [ { "id": "NP_808547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808547", "type": "external" } ], "gene_names_uniprotkb": "Sdk1", "gene_names_refseq": "5330440E10; 6720466O15Rik; Sdk1", "protein_names_uniprotkb": "Protein sidekick-1", "protein_names_refseq": "protein sidekick-1; sidekick homolog 1", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:330222); (R-MMU-373756)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;15213259;15703275;17307840;20219992;25428507;26287463;30084848;30150416;30899004;34418053;34428180;34545809", "class_list": "", "function": "-1 is an important mediator of cellular adhesion in HIV-infected podocytes and may contribute to podocyte clustering that is characteristic of pseudocrescent formation in HIV-associated nephropathy, [RefSeq, PubMed]; Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions., [UniProtKB, UniProtKB]; Results establish that the first and second immunoglobulin domains of sidekick-1 and -2 are necessary and sufficient to mediate and target homophilic adhesion, [RefSeq, PubMed]; Sidekick is expressed in ureteric bud and ureteric bud-derived tissues and may play a role in branching morphogenesis, [RefSeq, PubMed]; The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges. Publication Status: Online-Only, [RefSeq, PubMed]; The results suggest that the Ig-like domains and the fibronectin III (FnIII) domains of Sidekicks play different roles in cell adhesion. The Ig-like domains mediate the homophilic transinteractions bridging adjacent cells, while the FnIII domains interact with membranes, resulting in a tight adhesion interface between cells, [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 10, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 10, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 10, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 1, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFD1;Q6PAL2;Q6V3A4;Q8BMC2;Q8BZI1", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0007416 synapse assembly;GO:0048148 behavioral response to cocaine;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0010842 retina layer formation;GO:0060998 regulation of dendritic spine development", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q3UH53-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PDG5-1", "uniprot_id": [ { "id": "SMRC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PDG5", "type": "external" } ], "mass": 132604.0, "length": 1213, "protein_name": "SWI/SNF complex subunit SMARCC2", "gene_name": "Smarcc2", "organism": "Mouse", "refseq_name": "SWI/SNF complex subunit SMARCC2 isoform 2", "refseq_ac": [ { "id": "NP_001107568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107568", "type": "external" } ], "gene_names_uniprotkb": "Smarcc2; Baf170", "gene_names_refseq": "5930405J04Rik; Smarcc2", "protein_names_uniprotkb": "SWI/SNF complex subunit SMARCC2; BAF170; BRG1-associated factor 170; SWI/SNF complex 170 kDa subunit; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2", "protein_names_refseq": "BAF170; BRG1-associated factor 170; SWI/SNF complex 170 kDa subunit; SWI/SNF complex subunit SMARCC2 isoform 2; SWI/SNF complex subunit SMARCC2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2", "tax_id": 10090, "disease": "opportunistic bacterial infectious disease (Disease Ontology:DOID:0050340); Coffin-Siris syndrome 8 (Disease Ontology:DOID:0112367); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); Coffin-Siris syndrome (Disease Ontology:DOID:1925)", "pathway": " (mmu:68094); (R-MMU-3214858); (R-MMU-8939243); (R-MMU-9933939); (R-MMU-9933946); (R-MMU-9933947); (R-MMU-9934037)", "pathway_count": 7, "publication_count": 16, "publication_id_list": "15345747;16452087;17242355;17640523;19144319;21095589;21183079;21750661;22952240;26601204;28369036;29272704;31216030;34428180;35820727;39627609", "class_list": "", "function": "Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (PubMed:28369036)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6P3", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0071564 npBAF complex;GO:0016363 nuclear matrix;GO:0071565 nBAF complex", "go_biological_process": "GO:2000819 regulation of nucleotide-excision repair;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q6PDG5-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDU0-1", "uniprot_id": [ { "id": "GPSM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDU0", "type": "external" } ], "mass": 75591.0, "length": 679, "protein_name": "G protein-signaling modulator 2", "gene_name": "Gpsm2", "organism": "Mouse", "refseq_name": "G-protein-signaling modulator 2", "refseq_ac": [ { "id": "NP_083798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083798", "type": "external" } ], "gene_names_uniprotkb": "Gpsm2; Lgn; Pins", "gene_names_refseq": "6230410J09Rik; Gpsm2; LGN; Pins", "protein_names_uniprotkb": "G protein-signaling modulator 2; Pins homolog", "protein_names_refseq": "G-protein-signaling modulator 2; pins homolog (Drosophia)", "tax_id": 10090, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003); brain cancer (Disease Ontology:DOID:1319); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:76123); (R-MMU-418594)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "12571286;16094321;18084280;19122831;19144319;21183079;21750661;21816348;22952234;23318951;23665171;25428506;26766442;30084848;31112734", "class_list": "", "function": "Knocking out LGN, (the G protein regulator), randomized the orientation of normally planar neuroepithelial divisions., [RefSeq, PubMed]; Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity). Plays a role in metaphase spindle orientation (By similarity). Plays an important role in asymmetric cell divisions (PubMed:12571286, PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (PubMed:22952234)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; The primary aim of this study was to determine the spatial distribution and time course of mouse homolog of Drosophila Partner of Inscuteable (mPins) expression in the developing and adult mouse eye., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLX3", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0001965 G-protein alpha-subunit binding;GO:0070840 dynein complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005938 cell cortex;GO:0014069 postsynaptic density", "go_biological_process": "GO:1905832 positive regulation of spindle assembly;GO:0051301 cell division;GO:1904778 positive regulation of protein localization to cell cortex;GO:0051661 maintenance of centrosome location;GO:0060236 regulation of mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8VDU0-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQ95-1", "uniprot_id": [ { "id": "LNP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQ95", "type": "external" } ], "mass": 47500.0, "length": 425, "protein_name": "Endoplasmic reticulum junction formation protein lunapark", "gene_name": "Lnpk", "organism": "Mouse", "refseq_name": "endoplasmic reticulum junction formation protein lunapark isoform b", "refseq_ac": [ { "id": "NP_001103679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103679", "type": "external" } ], "gene_names_uniprotkb": "Lnpk; Kiaa1715; Lnpk1; Lnp; Uln", "gene_names_refseq": "2310011O18Rik; 4921514L11Rik; 9530051D01Rik; Lnpk1; Lnpk; Lnp; Ul; ulnaless", "protein_names_uniprotkb": "Endoplasmic reticulum junction formation protein lunapark; ER junction formation factor lunapark; Protein ulnaless", "protein_names_refseq": "ER junction formation factor 1; ER junction formation factor lunapark; endoplasmic reticulum junction formation protein lunapark isoform b; endoplasmic reticulum junction formation protein lunapark; limb and neural patterns; protein lunapark; protein ulnaless", "tax_id": 10090, "disease": "", "pathway": " (mmu:69605)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12732147;15345747;17114649;21183079;21750661;22645316;33501603;34428180;36288343", "class_list": "", "function": "Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within three-way ER tubular junction network. May be involved in limb and central nervous system development (PubMed:12732147)., [UniProtKB, UniProtKB, PubMed]; Maternal obesity during pregnancy leads to adipose tissue ER stress in mice via miR-126-mediated reduction in Lunapark., [RefSeq, PubMed]; Plays a role in determining ER morphology., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2ASL9;Q69ZC5;Q6PAQ1;Q6PEN8", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0097228 sperm principal piece", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0007596 blood coagulation;GO:0035115 embryonic forelimb morphogenesis;GO:0042733 embryonic digit morphogenesis;GO:0032330 regulation of chondrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q7TQ95-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08999-1", "uniprot_id": [ { "id": "LTBP2_MOUSE", "url": "https://www.uniprot.org/uniprot/O08999", "type": "external" } ], "mass": 195829.0, "length": 1813, "protein_name": "Latent-transforming growth factor beta-binding protein 2", "gene_name": "Ltbp2", "organism": "Mouse", "refseq_name": "latent-transforming growth factor beta-binding protein 2 isoform 2 precursor", "refseq_ac": [ { "id": "NP_038617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038617", "type": "external" } ], "gene_names_uniprotkb": "Ltbp2", "gene_names_refseq": "Ltbp2", "protein_names_uniprotkb": "Latent-transforming growth factor beta-binding protein 2; LTBP-2", "protein_names_refseq": "LTBP-2; latent-transforming growth factor beta-binding protein 2 isoform 2 precursor", "tax_id": 10090, "disease": "Weill-Marchesani syndrome (Disease Ontology:DOID:0050475); megalocornea (Disease Ontology:DOID:0060305); dilated cardiomyopathy (Disease Ontology:DOID:12930); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:16997); (R-MMU-2129379); (R-MMU-2173789)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10743502;11104663;11801660;19361779;21183079;21750661;26495903;31219806;31599954;33039488;35820727;37688792;9602168", "class_list": "", "function": "Latent-transforming growth factor beta-binding protein-2 (LTBP-2) is required for longevity but not for development of zonular fibers., [RefSeq, PubMed]; May play an integral structural role in elastic-fiber architectural organization and/or assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Multi-organ phenotypes in mice lacking latent TGFbeta binding protein 2 (LTBP2). Review article, [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q8C6W9", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0019838 growth factor binding;GO:0005509 calcium ion binding;GO:0050436 microfibril binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0001527 microfibril;GO:0071953 elastic fiber;GO:0099126 transforming growth factor beta complex", "go_biological_process": "GO:0097435 supramolecular fiber organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O08999-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53668-1", "uniprot_id": [ { "id": "LIMK1_MOUSE", "url": "https://www.uniprot.org/uniprot/P53668", "type": "external" } ], "mass": 72793.0, "length": 647, "protein_name": "LIM domain kinase 1", "gene_name": "Limk1", "organism": "Mouse", "refseq_name": "LIM domain kinase 1 isoform 1", "refseq_ac": [ { "id": "NP_034847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034847", "type": "external" } ], "gene_names_uniprotkb": "Limk1; Limk", "gene_names_refseq": "KIZ-1; LIMK-1; Limk1; Limk", "protein_names_uniprotkb": "LIM domain kinase 1; 2.7.11.1; KIZ-1; LIMK-1", "protein_names_refseq": "LIM domain kinase 1 isoform 1; LIM-domain containing, protein kinase", "tax_id": 10090, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (mmu:16885); (R-MMU-2029482); (R-MMU-399954); (R-MMU-5627123)", "pathway_count": 4, "publication_count": 22, "publication_id_list": "11003705;15056216;15660133;16204183;18332102;19696021;21183079;21750661;25107909;25605945;26733281;27549340;30016717;31361595;31599954;34315506;34407403;34428180;37718806;7478547;7848918;8541208", "class_list": "", "function": "NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms., [RefSeq, PubMed]; Overexpression of LIMK1 in hippocampal excitatory neurons improves synaptic plasticity and social recognition memory in APP/PS1 mice. Publication Status: Online-Only, [RefSeq, PubMed]; RhoA-LIMK Signaling Axis Reveals Rostral-Caudal Plane and Spatial Dysregulation in the Brain of Alzheimer's Disease Mouse Models., [RefSeq, PubMed]; Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:15056216, PubMed:16204183). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:15056216). Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; This gene encodes a member of the LIM kinase family of proteins. This protein is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein also stimulates axon growth and may play a role in brain development. Homozygous knockout mice for this gene exhibit reduced bone mass, abnormal neuronal morphology and altered synaptic function. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0031072 heat shock protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0006468 protein phosphorylation;GO:0030036 actin cytoskeleton organization;GO:0051496 positive regulation of stress fiber assembly;GO:0045773 positive regulation of axon extension", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P53668-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60469-1", "uniprot_id": [ { "id": "LIPA3_MOUSE", "url": "https://www.uniprot.org/uniprot/P60469", "type": "external" } ], "mass": 133426.0, "length": 1194, "protein_name": "Liprin-alpha-3", "gene_name": "Ppfia3", "organism": "Mouse", "refseq_name": "liprin-alpha-3", "refseq_ac": [ { "id": "NP_084017", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084017", "type": "external" } ], "gene_names_uniprotkb": "Ppfia3", "gene_names_refseq": "2410127E16Rik; Ppfia3", "protein_names_uniprotkb": "Liprin-alpha-3; PTPRF-interacting protein alpha-3; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3", "protein_names_refseq": "Liprin-alpha3; PTPRF-interacting protein alpha-3; liprin-alpha-3; protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:76787); (R-MMU-181429); (R-MMU-181430); (R-MMU-210500); (R-MMU-212676); (R-MMU-264642); (R-MMU-388844)", "pathway_count": 7, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;16452087;17114649;19013515;21183079;21750661;22645316;23124857;31599954;32848054;34031393;34428180;34678516;35822049", "class_list": "", "function": "May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates., [UniProtKB, UniProtKB]; PKC-phosphorylation of Liprin-alpha3 triggers phase separation and controls presynaptic active zone structure. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B8QI35", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0048786 presynaptic active zone", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0050808 synapse organization;GO:0007269 neurotransmitter secretion;GO:0016079 synaptic vesicle exocytosis;GO:0016081 synaptic vesicle docking", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P60469-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ST9-1", "uniprot_id": [ { "id": "LCA5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80ST9", "type": "external" } ], "mass": 80162.0, "length": 704, "protein_name": "Lebercilin", "gene_name": "Lca5", "organism": "Mouse", "refseq_name": "lebercilin isoform b", "refseq_ac": [ { "id": "NP_081724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081724", "type": "external" } ], "gene_names_uniprotkb": "Lca5", "gene_names_refseq": "4930431B11Rik; 5730406O13Rik; Lca5; ORF64", "protein_names_uniprotkb": "Lebercilin; Leber congenital amaurosis 5 protein homolog", "protein_names_refseq": "leber congenital amaurosis 5 protein homolog; lebercilin isoform b; lebercilin", "tax_id": 10090, "disease": "Leber congenital amaurosis 5 (Disease Ontology:DOID:0110215); Leber congenital amaurosis (Disease Ontology:DOID:14791)", "pathway": " (mmu:75782)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17546029;21183079;21606596;21750661;34428180", "class_list": "", "function": "Involved in intraflagellar transport complex-mediated outer segment protein trafficking in photoreceptor cilia (PubMed:21606596). Plays a role in the ciliary transport of photoreceptors outer segment proteins (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CYM9;Q9D5J9", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005929 cilium;GO:0005814 centriole", "go_biological_process": "GO:0015031 protein transport;GO:0045494 photoreceptor cell maintenance;GO:0042073 intraciliary transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80ST9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CG19-1", "uniprot_id": [ { "id": "LTBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CG19", "type": "external" } ], "mass": 186717.0, "length": 1712, "protein_name": "Latent-transforming growth factor beta-binding protein 1", "gene_name": "Ltbp1", "organism": "Mouse", "refseq_name": "latent-transforming growth factor beta-binding protein 1 isoform 7 precursor", "refseq_ac": [ { "id": "NP_001318166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001318166", "type": "external" } ], "gene_names_uniprotkb": "Ltbp1", "gene_names_refseq": "9430031G15Rik; 9830146M04; Ltbp-1; Ltbp1L; Ltbp1; TGF-beta1-BP-1; Tgfb; b2b1000Clo", "protein_names_uniprotkb": "Latent-transforming growth factor beta-binding protein 1; LTBP-1; TGF-beta1-BP-1; Transforming growth factor beta-1-binding protein 1", "protein_names_refseq": "latent TGF beta binding protein; latent transforming growth factor beta binding protein 1L; latent-transforming growth factor beta-binding protein 1 isoform 7 precursor; transforming growth factor beta-1-binding protein 1", "tax_id": 10090, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224); glomerulonephritis (Disease Ontology:DOID:2921); cutis laxa (Disease Ontology:DOID:3144)", "pathway": " (mmu:268977); (R-MMU-2129379); (R-MMU-2173789); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10743502;11104663;12711388;12711389;21183079;21750661;31219806;34428180;35676846;39950214", "class_list": "", "function": "Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; LTBP1 Gene Expression in the Cerebral Cortex and its Neuroprotective Mechanism in Mice with Postischemic Stroke Epilepsy., [RefSeq, PubMed]", "predicted_glycosites": 15, "predicted_n_glycosites": 4, "predicted_o_glycosites": 11, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "B1B1D9;B1B1E1;O88349;Q505C9;Q8BNW7;Q8C7F5;Q8CG18;Q8CIR0", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005509 calcium ion binding;GO:0050431 transforming growth factor beta binding;GO:0050436 microfibril binding;GO:0141069 receptor ligand inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030425 dendrite;GO:0031012 extracellular matrix;GO:0043025 neuronal cell body;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0035583 sequestering of TGFbeta in extracellular matrix;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0032967 positive regulation of collagen biosynthetic process;GO:0003281 ventricular septum development;GO:0035904 aorta development", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8CG19-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88653-1", "uniprot_id": [ { "id": "LTOR3_MOUSE", "url": "https://www.uniprot.org/uniprot/O88653", "type": "external" } ], "mass": 13553.0, "length": 124, "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "Lamtor3", "organism": "Mouse", "refseq_name": "ragulator complex protein LAMTOR3", "refseq_ac": [ { "id": "NP_064304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064304", "type": "external" } ], "gene_names_uniprotkb": "Lamtor3; Map2k1ip1; Mapbp; Mapksp1", "gene_names_refseq": "Lamtor3; Map2k1ip1; Mapbp; Mapksp1; Mp1", "protein_names_uniprotkb": "Ragulator complex protein LAMTOR3; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3; MEK-binding partner 1; Mitogen-activated protein kinase kinase 1-interacting protein 1; Mitogen-activated protein kinase scaffold protein 1; Mp1", "protein_names_refseq": "MAPK scaffold protein 1; MEK binding partner 1; late endosomal/lysosomal adaptor and MAPK and MTOR activator 3; mitogen activated protein, binding protein; mitogen-activated protein kinase kinase 1-interacting protein 1; mitogen-activated protein kinase scaffold protein 1; ragulator complex protein LAMTOR3", "tax_id": 10090, "disease": "", "pathway": " (mmu:56692); (R-MMU-1632852); (R-MMU-165159); (R-MMU-166208); (R-MMU-380972); (R-MMU-5628897); (R-MMU-5674135); (R-MMU-6798695); (R-MMU-8943724); (R-MMU-9639288)", "pathway_count": 10, "publication_count": 21, "publication_id_list": "11266467;15118098;15263099;18299400;19177150;19892989;20484733;21750661;21952136;23653355;24463270;24841562;25428506;25428507;25605945;26740625;30084848;30779550;34428180;35820727;9733512", "class_list": "", "function": "As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:15263099). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (By similarity). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity). Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (PubMed:9733512)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Data indicate that LAMTOR3 protein is stabilized by associating with LAMTOR2., [RefSeq, PubMed]; This novel mechanism for localization of intracellular Leishmania amazonensis-mediated ERK1/2 phosphorylation required the endosomal scaffold protein MP1 and localized to Leishmania amazonensis parasitophorous vacuoles., [RefSeq, PubMed]; We show an essential function for late endosomes carrying the p14-MP1 (LAMTOR2/3) complex in focal adhesion dynamics., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019209 kinase activator activity;GO:0060090 molecular adaptor activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0005770 late endosome;GO:0071986 Ragulator complex;GO:1990877 FNIP-folliculin RagC/D GAP", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0043410 positive regulation of MAPK cascade;GO:0032008 positive regulation of TOR signaling;GO:0008104 intracellular protein localization;GO:0038202 TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "O88653-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P45700-1", "uniprot_id": [ { "id": "MA1A1_MOUSE", "url": "https://www.uniprot.org/uniprot/P45700", "type": "external" } ], "mass": 73276.0, "length": 655, "protein_name": "Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA", "gene_name": "Man1a1; Man1a", "organism": "Mouse", "refseq_name": "mannosyl-oligosaccharide 1,2-alpha-mannosidase IA", "refseq_ac": [ { "id": "NP_032574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032574", "type": "external" } ], "gene_names_uniprotkb": "Man1a1; Man1a; Man1a", "gene_names_refseq": "Man1a1; Man1a; PCR1", "protein_names_uniprotkb": "Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA; 3.2.1.113; Alpha-1,2-mannosidase IA; Man(9)-alpha-mannosidase; Man9-mannosidase; Mannosidase alpha class 1A member 1; Processing alpha-1,2-mannosidase IA", "protein_names_refseq": "alpha-1,2-mannosidase IA; man(9)-alpha-mannosidase; man9-mannosidase; mannosidase alpha class 1A member 1; mannosyl-oligosaccharide 1,2-alpha-mannosidase IA; mannosyl-oligosaccharide alpha-1,2-mannosidase; processing alpha-1,2-mannosidase IA", "tax_id": 10090, "disease": "", "pathway": " (mmu:17155); (R-MMU-964827)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;15102839;17456197;21577142;21750661;26495903;26740625;27856750;30084848;31219806;34428180;8144580", "class_list": "glycogene;glycosylhydrolase", "function": "Complex N-glycans generated by enzymes such as a-mannosidase I inhibit the activation of naive T cells., [RefSeq, PubMed]; Downregulation of TOAG-1 and alpha-1,2-mannosidase expression occurred in graft infiltrating cells and expression of both genes was also downregulated after T-cell activation in vitro, [RefSeq, PubMed]; In the bound substrate complex, hydrophobic stacking interactions between Trp residues and the glycan core anchor the base of the glycan structure to the enzyme cleft, [RefSeq, PubMed]; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 26, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.113", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.113", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0031410 cytoplasmic vesicle;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment;GO:0016020 membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0036503 ERAD pathway;GO:0045047 protein targeting to ER", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P45700-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.100.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BLC3-1", "uniprot_id": [ { "id": "LYPD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BLC3", "type": "external" } ], "mass": 15261.0, "length": 141, "protein_name": "Ly6/PLAUR domain-containing protein 1", "gene_name": "Lypd1", "organism": "Mouse", "refseq_name": "ly6/PLAUR domain-containing protein 1 isoform b", "refseq_ac": [ { "id": "NP_001298018", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298018", "type": "external" } ], "gene_names_uniprotkb": "Lypd1; Lypdc1; MNCb-0671", "gene_names_refseq": "2700050C12Rik; C530008O16Rik; Lynx2; Lypd1; Lypdc1", "protein_names_uniprotkb": "Ly6/PLAUR domain-containing protein 1; Ly-6/neurotoxin-like protein 2; Lynx2", "protein_names_refseq": "ly-6/neurotoxin-like protein 2; ly6/PLAUR domain-containing protein 1 isoform b; ly6/PLAUR domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72585); (R-MMU-163125)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "16236524;19246390;21750661;25716842;26276394", "class_list": "", "function": "Altered glutamatergic signaling in the prefrontal cortex of Lynx2 mutant mice contributes to increased anxiety-related behaviors, [RefSeq, PubMed]; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs (PubMed:19246390). May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface (PubMed:25716842, PubMed:26276394). May be involved in the control of anxiety (PubMed:19246390)., [UniProtKB, PubMed, PubMed, PubMed]; Cloning and characterization of lynx2; lynx2 is expressed in a large number of neuronal structures but only in discrete postmitotic neurons, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2X5;Q3V447;Q9JJ96", "ec_number_list": [], "go_molecular_function": "GO:0033130 acetylcholine receptor binding;GO:0030550 acetylcholine receptor inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse;GO:0098552 side of membrane", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0035094 response to nicotine;GO:0095500 acetylcholine receptor signaling pathway;GO:0001662 behavioral fear response;GO:1903077 negative regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BLC3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9QA62-1", "uniprot_id": [ { "id": "LMOD3_MOUSE", "url": "https://www.uniprot.org/uniprot/E9QA62", "type": "external" } ], "mass": 65689.0, "length": 571, "protein_name": "Leiomodin-3", "gene_name": "Lmod3", "organism": "Mouse", "refseq_name": "leiomodin-3", "refseq_ac": [ { "id": "NP_001074626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074626", "type": "external" } ], "gene_names_uniprotkb": "Lmod3", "gene_names_refseq": "5430424A14Rik; Lmod3", "protein_names_uniprotkb": "Leiomodin-3", "protein_names_refseq": "leiomodin-3", "tax_id": 10090, "disease": "nemaline myopathy 10 (Disease Ontology:DOID:0110931); nemaline myopathy (Disease Ontology:DOID:3191)", "pathway": " (mmu:320502)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "24960163;25774500;26035871;32980291", "class_list": "", "function": "Essential for the organization of sarcomeric actin thin filaments in skeletal muscle (PubMed:25774500, PubMed:26035871). Increases the rate of actin polymerization (By similarity)., [UniProtKB, PubMed, UniProtKB]; LMOD3 deficiency in mice causes nemaline myopathy. In skeletal muscle, Lmod3 transcription was controlled by SRF and MEF2. LMOD3 and KLHL40 enhanced MRTF-SRF activity., [RefSeq, PubMed]; Lmod3 promotes myoblast differentiation and proliferation via the AKT and ERK pathways., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AUN8;A0JP45", "ec_number_list": [], "go_molecular_function": "GO:0003785 actin monomer binding;GO:0005523 tropomyosin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005865 striated muscle thin filament;GO:0031430 M band;GO:0030016 myofibril", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0030240 skeletal muscle thin filament assembly;GO:0048741 skeletal muscle fiber development;GO:0006941 striated muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E9QA62-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14733-1", "uniprot_id": [ { "id": "LMNB1_MOUSE", "url": "https://www.uniprot.org/uniprot/P14733", "type": "external" } ], "mass": 66786.0, "length": 588, "protein_name": "Lamin-B1", "gene_name": "Lmnb1", "organism": "Mouse", "refseq_name": "lamin-B1", "refseq_ac": [ { "id": "NP_034851", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034851", "type": "external" } ], "gene_names_uniprotkb": "Lmnb1", "gene_names_refseq": "Lmnb1", "protein_names_uniprotkb": "Lamin-B1", "protein_names_refseq": "lamin-B1", "tax_id": 10090, "disease": "congenital muscular dystrophy (Disease Ontology:DOID:0050557); autosomal dominant primary microcephaly 26 (Disease Ontology:DOID:0051037); typical adult-onset autosomal dominant demyelinating leukodystrophy (Disease Ontology:DOID:0060785); familial partial lipodystrophy type 2 (Disease Ontology:DOID:0070202); autosomal dominant Emery-Dreifuss muscular dystrophy 2 (Disease Ontology:DOID:0070247); autosomal recessive Emery-Dreifuss muscular dystrophy 3 (Disease Ontology:DOID:0070248); dilated cardiomyopathy 1A (Disease Ontology:DOID:0110425); congenital muscular dystrophy due to LMNA mutation (Disease Ontology:DOID:0110640); Emery-Dreifuss muscular dystrophy (Disease Ontology:DOID:11726); progeria (Disease Ontology:DOID:3911); myopathy (Disease Ontology:DOID:423); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:16906); (R-MMU-2559584); (R-MMU-2980766); (R-MMU-2995383); (R-MMU-352238); (R-MMU-4419969); (R-MMU-9035034)", "pathway_count": 7, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19144319;21183079;21389115;23806337;25153642;25605945;26495903;28241138;3243285;33725478;34418053;34428180;37507081;38870534;39627609;8586436", "class_list": "", "function": "Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28241138). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28241138). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28241138). Plays a role in sperm morphological development during late stages of spermiogenesis, particularly the anchoring of the sperm head to the tail (PubMed:38870534). Component of the LMNB1/SUN5/SEPT12 bridge that connects the sperm proximal centriole to the implantation fossa, the bridge functions to prevent detachment of the proximal centriole from the posterior nucleus during steps 13 to 16 of spermiogenesis (PubMed:38870534)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 12, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q61791", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0003690 double-stranded DNA binding;GO:0043274 phospholipase binding;GO:0008432 JUN kinase binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0016363 nuclear matrix", "go_biological_process": "GO:0090435 protein localization to nuclear envelope;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0046330 positive regulation of JNK cascade;GO:0006998 nuclear envelope organization;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P14733-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28301-1", "uniprot_id": [ { "id": "LYOX_MOUSE", "url": "https://www.uniprot.org/uniprot/P28301", "type": "external" } ], "mass": 46701.0, "length": 411, "protein_name": "Protein-lysine 6-oxidase", "gene_name": "Lox", "organism": "Mouse", "refseq_name": "protein-lysine 6-oxidase preproprotein", "refseq_ac": [ { "id": "NP_001273110", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273110", "type": "external" } ], "gene_names_uniprotkb": "Lox; Rrg", "gene_names_refseq": "Lox; TSC-160; rrg", "protein_names_uniprotkb": "Protein-lysine 6-oxidase; 1.4.3.13; Lysyl oxidase; Ras excision protein", "protein_names_refseq": "protein-lysine 6-oxidase preproprotein; protein-lysine 6-oxidase; ras excision protein", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); thoracic aortic aneurysm (Disease Ontology:DOID:14004); Menkes disease (Disease Ontology:DOID:1838); Williams-Beuren syndrome (Disease Ontology:DOID:1928); colon adenocarcinoma (Disease Ontology:DOID:234); arteriosclerosis (Disease Ontology:DOID:2349); coronary artery disease (Disease Ontology:DOID:3393); coronary restenosis (Disease Ontology:DOID:4247); abdominal aortic aneurysm (Disease Ontology:DOID:7693); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:16948); (R-MMU-1566948); (R-MMU-2243919)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15277520;16251195;1678898;20181949;27432961;34428180;8100214", "class_list": "", "function": "Lysyl oxidase functions to inhibit ras-dependent cell transformation, [RefSeq, PubMed]; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (PubMed:27432961)., [UniProtKB, PubMed]; This gene encodes a precursor protein that belongs to the lysyl oxidase family of proteins. The secreted proprotein is proteolytically processed to an active mature peptide and a propeptide. This propeptide is thought to function in tumor suppression by inhibiting the Ras signaling pathway. The active enzyme plays a role in cross-linking of collagen and elastin and is essential for development of cardiovascular and respiratory systems, and development of skin and connective tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.13", "type": "external" }, { "id": "3.4.24.19", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.19", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005518 collagen binding;GO:0005507 copper ion binding;GO:0036094 small molecule binding;GO:0004720 protein-lysine 6-oxidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005581 collagen trimer;GO:0001527 microfibril", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0016202 regulation of striated muscle tissue development;GO:0071897 DNA biosynthetic process;GO:1990869 cellular response to chemokine;GO:1903010 regulation of bone development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P28301-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10085-1", "uniprot_id": [ { "id": "MYOD1_MOUSE", "url": "https://www.uniprot.org/uniprot/P10085", "type": "external" } ], "mass": 34233.0, "length": 318, "protein_name": "Myoblast determination protein 1", "gene_name": "Myod1", "organism": "Mouse", "refseq_name": "myoblast determination protein 1", "refseq_ac": [ { "id": "NP_034996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034996", "type": "external" } ], "gene_names_uniprotkb": "Myod1; Myod", "gene_names_refseq": "MYF3; MyoD; Myod-1; Myod1; bHLHc1", "protein_names_uniprotkb": "Myoblast determination protein 1", "protein_names_refseq": "myoblast determination protein 1", "tax_id": 10090, "disease": "congenital myopathy 17 (Disease Ontology:DOID:0081349); hypertension (Disease Ontology:DOID:10763); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); musculoskeletal system disease (Disease Ontology:DOID:17); congestive heart failure (Disease Ontology:DOID:6000); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:17927); (R-MMU-525793)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "10082583;10764802;10838091;11532390;12037670;12887892;14749395;16901893;17011493;1754380;17761773;19723804;20026657;20124407;21798092;21832073;22569126;3175662;32820177;3286015;3690668;40023397;8181063;9029156;9343420", "class_list": "", "function": "Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation (PubMed:16901893). Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (PubMed:21798092, PubMed:3175662)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C6B1", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0007518 myoblast fate determination;GO:0014904 myotube cell development;GO:0043335 protein unfolding;GO:1905382 positive regulation of snRNA transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P10085-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23708-1", "uniprot_id": [ { "id": "NFYA_MOUSE", "url": "https://www.uniprot.org/uniprot/P23708", "type": "external" } ], "mass": 36779.0, "length": 346, "protein_name": "Nuclear transcription factor Y subunit alpha", "gene_name": "Nfya", "organism": "Mouse", "refseq_name": "nuclear transcription factor Y subunit alpha isoform c", "refseq_ac": [ { "id": "NP_001334330", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334330", "type": "external" } ], "gene_names_uniprotkb": "Nfya", "gene_names_refseq": "Cbf-b; Nfya; SEZ-10; SEZ10", "protein_names_uniprotkb": "Nuclear transcription factor Y subunit alpha; CAAT box DNA-binding protein subunit A; NF-YA; Nuclear transcription factor Y subunit A", "protein_names_refseq": "CAAT box DNA-binding protein subunit A; nuclear transcription factor Y subunit A; nuclear transcription factor Y subunit alpha isoform c; nuclear transcription factor Y subunit alpha", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:18044)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "1549471;1577736;1698608;21183079;21750661;24030830;37972593;38199563;40997131", "class_list": "", "function": "Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component BMAL1., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The transcription factor NF-YA is crucial for neural progenitor maintenance during brain development., [RefSeq, PubMed]; Transcription factor NFYa controls cardiomyocyte metabolism and proliferation during mouse fetal heart development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032993 protein-DNA complex;GO:0090575 RNA polymerase II transcription regulator complex;GO:0016602 CCAAT-binding factor complex", "go_biological_process": "GO:2000648 positive regulation of stem cell proliferation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P23708-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4I7-1", "uniprot_id": [ { "id": "NETO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R4I7", "type": "external" } ], "mass": 60242.0, "length": 533, "protein_name": "Neuropilin and tolloid-like protein 1", "gene_name": "Neto1", "organism": "Mouse", "refseq_name": "neuropilin and tolloid-like protein 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_659195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659195", "type": "external" } ], "gene_names_uniprotkb": "Neto1; Btcl1", "gene_names_refseq": "Btcl1; C130005O10Rik; Neto1", "protein_names_uniprotkb": "Neuropilin and tolloid-like protein 1; Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1", "protein_names_refseq": "brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1; neuropilin and tolloid-like protein 1 isoform 1 precursor; neuropilin and tolloid-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:246317)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11943477;12810072;15464227;16452087;18034455;19243221;21593317;21750661;31628192;37586617", "class_list": "", "function": "Aging to 24 months increased C57BL/6J mouse social sniffing and hippocampal Neto1 levels, and impaired female spatial learning., [RefSeq, PubMed]; Assembly with NETO1 and NETO2 differentially modifies homomeric glutamate K1 (GluK1) kainate receptor gating., [RefSeq, PubMed]; Data describe the isolation and characterization of a novel gene, Btcl1 (brain-specific transmembrane protein containing two CUB and an LDLa domains), which has significant homology with neuropilin-1 and -2 in their CUB domains. [Btcl1], [RefSeq, PubMed]; Focuses mainly on human NETO1 but also describes identification of mouse Neto1., [RefSeq, PubMed]; Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory., [UniProtKB, PubMed, PubMed]; Neto1 and Neto2 differentially regulate GluK2 fast gating kinetics, [RefSeq, PubMed]; Neto1 regulates NMDA receptor-dependent synaptic plasticity and cognition., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q80X39;Q8C4S3;Q8CCM2", "ec_number_list": [], "go_molecular_function": "GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0014069 postsynaptic density;GO:0045202 synapse;GO:1904115 axon cytoplasm;GO:0060076 excitatory synapse", "go_biological_process": "GO:0007613 memory;GO:0008542 visual learning;GO:0048169 regulation of long-term neuronal synaptic plasticity;GO:2000463 positive regulation of excitatory postsynaptic potential;GO:0097120 receptor localization to synapse", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8R4I7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZN6-1", "uniprot_id": [ { "id": "DOC10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZN6", "type": "external" } ], "mass": 249576.0, "length": 2187, "protein_name": "Dedicator of cytokinesis protein 10", "gene_name": "Dock10", "organism": "Mouse", "refseq_name": "dedicator of cytokinesis protein 10 isoform 2", "refseq_ac": [ { "id": "NP_001272856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272856", "type": "external" } ], "gene_names_uniprotkb": "Dock10; Kiaa0694; Ziz3", "gene_names_refseq": "9330153B10Rik; A630054M16Rik; Dock10; Jr4; Jr5; ZIZ3; Zizimin3; mKIAA0694", "protein_names_uniprotkb": "Dedicator of cytokinesis protein 10; Zizimin-3", "protein_names_refseq": "dedicator of cytokinesis protein 10 isoform 2; dedicator of cytokinesis protein 10; zizimin-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:210293); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013423); (R-MMU-983231)", "pathway_count": 6, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;15710388;19144319;21183079;21514340;21750661;25729399;25851601;27502165;29187734;30084848;30779550;36077014;36848820;40885482", "class_list": "", "function": "Dock10 Regulates Cardiac Function under Neurohormonal Stress. Publication Status: Online-Only, [RefSeq, PubMed]; Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway (PubMed:25851601). Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression (PubMed:27502165)., [UniProtKB, PubMed, PubMed]; Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor., [RefSeq, PubMed]; T cells and B cells exhibited inverse expression patterns of the DOCK10 isoforms, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A087WQ86;E9QM99;F1AHI9", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043547 positive regulation of GTPase activity;GO:0007264 small GTPase-mediated signal transduction;GO:0035023 regulation of Rho protein signal transduction;GO:0030334 regulation of cell migration;GO:0060997 dendritic spine morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8BZN6-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDQ8-1", "uniprot_id": [ { "id": "SIR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDQ8", "type": "external" } ], "mass": 43256.0, "length": 389, "protein_name": "NAD-dependent protein deacetylase sirtuin-2", "gene_name": "Sirt2", "organism": "Mouse", "refseq_name": "NAD-dependent protein deacetylase sirtuin-2 isoform 2", "refseq_ac": [ { "id": "NP_001116237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116237", "type": "external" } ], "gene_names_uniprotkb": "Sirt2; Sir2l2", "gene_names_refseq": "5730427M03Rik; SIR2L2; Sir2l; Sirt2", "protein_names_uniprotkb": "NAD-dependent protein deacetylase sirtuin-2; 2.3.1.-; 2.3.1.286; NAD-dependent protein deacylase sirtuin-2; NAD-dependent protein defatty-acylase sirtuin-2; Regulatory protein SIR2 homolog 2; SIR2-like protein 2; mSIR2L2", "protein_names_refseq": "NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacetylase sirtuin-2 isoform 2; NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacylase sirtuin-2; NAD-dependent protein defatty-acylase sirtuin-2; SIR2-like protein 2; mSIR2L2; regulatory protein SIR2 homolog 2; silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); high grade glioma (Disease Ontology:DOID:3070); intermittent claudication (Disease Ontology:DOID:3669); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:64383); (R-MMU-2995383)", "pathway_count": 2, "publication_count": 32, "publication_id_list": "10.1101/2023.09.13.557529;11056054;15345747;16933150;17242355;17521387;17574768;17634366;17681146;18332217;19037106;19144319;21183079;21750661;21791548;21841822;21949390;22014574;22517741;22645316;22943040;23468428;24177535;24334550;24460154;29158185;30154464;32848054;34059674;34428180;40021952;40885482", "class_list": "", "function": "Deacetylates alpha-tubulin., [UniProtKB, PubMed]; In oligodendrocytes, targeting of SirT2 to paranodes coincides with presence of the microtubule-destabilizing protein stathmin-1 during early myelinogenesis & suggests the existence of a microtubule regulatory network that modulates cytoskeletal dynamics., [RefSeq, PubMed]; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (PubMed:17521387, PubMed:17574768, PubMed:17681146, PubMed:19037106, PubMed:21791548, PubMed:21841822, PubMed:22014574, PubMed:24334550, PubMed:34059674). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtubule stress agents, and hence allowing proper inheritance of chromosomes. Positively regulates the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex activity by deacetylating CDC20 and FZR1, then allowing progression through mitosis. Associates both with chromatin at transcriptional start sites (TSSs) and enhancers of active genes. Plays a role in cell cycle and chromatin compaction through epigenetic modulation of the regulation of histone H4 'Lys-20' methylation (H4K20me1) during early mitosis. Specifically deacetylates histone H4 at 'Lys-16' (H4K16ac) between the G2/M transition and metaphase enabling H4K20me1 deposition by KMT5A leading to ulterior levels of H4K20me2 and H4K20me3 deposition throughout cell cycle, and mitotic S-phase progression. Deacetylates KMT5A modulating KMT5A chromatin localization during the mitotic stress response. Also deacetylates histone H3 at 'Lys-57' (H3K56ac) during the mitotic G2/M transition. During oocyte meiosis progression, may deacetylate histone H4 at 'Lys-16' (H4K16ac) and alpha-tubulin, regulating spindle assembly and chromosome alignment by influencing microtubule dynamics and kinetochore function. Deacetylates histone H4 at 'Lys-16' (H4K16ac) at the VEGFA promoter and thereby contributes to regulate expression of VEGFA, a key regulator of angiogenesis. Deacetylates alpha-tubulin at 'Lys-40' and hence controls neuronal motility, oligodendroglial cell arbor projection processes and proliferation of non-neuronal cells (PubMed:17574768, PubMed:21791548). Phosphorylation at Ser-368 by a G1/S-specific cyclin E-CDK2 complex inactivates SIRT2-mediated alpha-tubulin deacetylation, negatively regulating cell adhesion, cell migration and neurite outgrowth during neuronal differentiation. Deacetylates PARD3 and participates in the regulation of Schwann cell peripheral myelination formation during early postnatal development and during postinjury remyelination. Involved in several cellular metabolic pathways. Plays a role in the regulation of blood glucose homeostasis by deacetylating and stabilizing phosphoenolpyruvate carboxykinase PCK1 activity in response to low nutrient availability. Acts as a key regulator in the pentose phosphate pathway (PPP) by deacetylating and activating the glucose-6-phosphate G6PD enzyme, and therefore, stimulates the production of cytosolic NADPH to counteract oxidative damage. Maintains energy homeostasis in response to nutrient deprivation as well as energy expenditure by inhibiting adipogenesis and promoting lipolysis. Attenuates adipocyte differentiation by deacetylating and promoting FOXO1 interaction to PPARG and subsequent repression of PPARG-dependent transcriptional activity (PubMed:17681146, PubMed:19037106). Plays a role in the regulation of lysosome-mediated degradation of protein aggregates by autophagy in neuronal cells (PubMed:17681146, PubMed:19037106). Deacetylates FOXO1 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagy (PubMed:17681146, PubMed:19037106). Deacetylates a broad range of transcription factors and co-regulators regulating target gene expression (PubMed:34059674). Deacetylates transcriptional factor FOXO3 stimulating the ubiquitin ligase SCF(SKP2)-mediated FOXO3 ubiquitination and degradation (PubMed:17521387, PubMed:21841822). Deacetylates HIF1A and therefore promotes HIF1A degradation and inhibition of HIF1A transcriptional activity in tumor cells in response to hypoxia. Deacetylates RELA in the cytoplasm inhibiting NF-kappaB-dependent transcription activation upon TNF stimulation. Inhibits transcriptional activation by deacetylating p53/TP53 and EP300. Also deacetylates EIF5A. In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of N(6)-benzoyl (benzoyl) and N(6)-methacryl (methacryl) acyl groups from lysine residues, leading to histone debenzoylation and demethacrylation, respectively (PubMed:30154464). Functions as a negative regulator on oxidative stress-tolerance in response to anoxia-reoxygenation conditions. Plays a role as tumor suppressor (PubMed:22014574, PubMed:23468428). In addition to protein deacetylase activity, also has activity toward long-chain fatty acyl groups and mediates protein-lysine demyristoylation and depalmitoylation of target proteins, such as ARF6 and KRAS, thereby regulating their association with membranes (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; NAD-dependent protein deacetylase., [UniProtKB, UniProtKB]; SIRT2 responds to caloric restriction and oxidative stress to deacetylate FOXO transcription factors, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9PXF5;Q9CXS5;Q9EQ18;Q9ERJ9;U5TP50", "ec_number_list": [ { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" } ], "go_molecular_function": "GO:0046970 histone H4K16 deacetylase activity, NAD-dependent;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding;GO:0070403 NAD+ binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0035748 myelin sheath abaxonal region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0045836 positive regulation of meiotic nuclear division;GO:0061433 cellular response to caloric restriction;GO:0070446 negative regulation of oligodendrocyte progenitor proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "Q8VDQ8-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05A62-1", "uniprot_id": [ { "id": "DNAL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q05A62", "type": "external" } ], "mass": 21465.0, "length": 190, "protein_name": "Dynein axonemal light chain 1", "gene_name": "Dnal1", "organism": "Mouse", "refseq_name": "dynein axonemal light chain 1 isoform 2", "refseq_ac": [ { "id": "NP_001333457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333457", "type": "external" } ], "gene_names_uniprotkb": "Dnal1; Dnalc1", "gene_names_refseq": "1700010H15Rik; Dnal1; Dnalc1; E330027P08Rik", "protein_names_uniprotkb": "Dynein axonemal light chain 1", "protein_names_refseq": "dynein axonemal light chain 1 isoform 2; dynein light chain 1, axonemal", "tax_id": 10090, "disease": "primary ciliary dyskinesia 16 (Disease Ontology:DOID:0110613)", "pathway": " (mmu:105000)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15845866;21183079;21750661;25428506;25428507;25605945;30084848;34428180", "class_list": "", "function": "Analysis of the human (DNAL1) and murine (Dnal1) orthologs of the Chlamydomonas LC1-gene, [RefSeq, PubMed]; Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JLX1;Q9DAH9", "ec_number_list": [], "go_molecular_function": "GO:0043014 alpha-tubulin binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0005874 microtubule;GO:0036157 outer dynein arm", "go_biological_process": "GO:0036158 outer dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q05A62-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q9R9-1", "uniprot_id": [ { "id": "DLG5_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q9R9", "type": "external" } ], "mass": 214386.0, "length": 1921, "protein_name": "Disks large homolog 5", "gene_name": "Dlg5", "organism": "Mouse", "refseq_name": "disks large homolog 5 isoform 1", "refseq_ac": [ { "id": "NP_001156985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156985", "type": "external" } ], "gene_names_uniprotkb": "Dlg5", "gene_names_refseq": "4933429D20Rik; Dlg5; mKIAA0583", "protein_names_uniprotkb": "Disks large homolog 5", "protein_names_refseq": "discs, large homolog 5; disks large homolog 5 isoform 1; disks large homolog 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:71228); (R-MMU-9013420); (R-MMU-9013424); (R-MMU-9696264); (R-MMU-9696270); (R-MMU-9696273)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "20436275;21183079;21750661;22645316;23466739;25232112;25644602;28087714;34428180;35820727", "class_list": "", "function": "Acts as a regulator of the Hippo signaling pathway. Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (By similarity). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin (PubMed:25232112). Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (PubMed:25644602)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Data report that Discs large 5 (Dlg5), a member of the MAGUK family, is an interactor of CitK required for CitK polarization., [RefSeq, PubMed]; Dlg5 is required for Hh-induced enrichment of Kif7 and Gli2 at the tip of the cilium but is dispensable for Gpr161 exit from the cilium and the consequent suppression of Gli3 processing into its repressor form, [RefSeq, PubMed]; Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGX5", "ec_number_list": [], "go_molecular_function": "GO:0008092 cytoskeletal protein binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0014069 postsynaptic density;GO:0030054 cell junction", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0030336 negative regulation of cell migration;GO:0042130 negative regulation of T cell proliferation;GO:0051965 positive regulation of synapse assembly;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "E9Q9R9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESX5-1", "uniprot_id": [ { "id": "DKC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ESX5", "type": "external" } ], "mass": 57402.0, "length": 509, "protein_name": "H/ACA ribonucleoprotein complex subunit DKC1", "gene_name": "Dkc1", "organism": "Mouse", "refseq_name": "H/ACA ribonucleoprotein complex subunit DKC1 isoform 3", "refseq_ac": [ { "id": "NP_001025478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025478", "type": "external" } ], "gene_names_uniprotkb": "Dkc1", "gene_names_refseq": "Dkc1", "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex subunit DKC1; 5.4.99.-; Dyskerin; Nopp140-associated protein of 57 kDa; Nucleolar protein NAP57; Nucleolar protein family A member 4; snoRNP protein DKC1", "protein_names_refseq": "H/ACA ribonucleoprotein complex subunit DKC1 isoform 3; H/ACA ribonucleoprotein complex subunit DKC1; dyskeratosis congenita 1, dyskerin homolog; dyskerin; h/ACA ribonucleoprotein complex subunit 4; nopp140-associated protein of 57 kDa; nucleolar protein NAP57; nucleolar protein family A member 4; snoRNP protein DKC1", "tax_id": 10090, "disease": "X-linked dyskeratosis congenita (Disease Ontology:DOID:0070025); aplastic anemia (Disease Ontology:DOID:12449); dyskeratosis congenita (Disease Ontology:DOID:2729)", "pathway": " (mmu:245474); (R-MMU-171319); (R-MMU-174430)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10903840;12522253;15240872;16452087;17242355;18630941;19131326;19144319;21183079;21750661;34887587;37097350;37426487;37828378", "class_list": "", "function": "Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:12522253, PubMed:15240872). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs (PubMed:12522253, PubMed:15240872). Required for ribosome biogenesis and telomere maintenance (By similarity). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Mechanism of Dcp2/RNCR3/Dkc1/Snora62 axis regulating neuronal apoptosis in chronic cerebral ischemia., [RefSeq, PubMed]; MiRNA326-5p Targets DKC1 Gene to Regulate Apoptosis-Related Proteins and Intervene in the Development of Neuroblastoma. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UWE5", "ec_number_list": [ { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0003720 telomerase activity;GO:0009982 pseudouridine synthase activity;GO:0034513 box H/ACA snoRNA binding;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0001650 fibrillar center;GO:0015030 Cajal body", "go_biological_process": "GO:0000455 enzyme-directed rRNA pseudouridine synthesis;GO:0090666 scaRNA localization to Cajal body;GO:0008284 positive regulation of cell population proliferation;GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0000495 box H/ACA sno(s)RNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9ESX5-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P1D7-1", "uniprot_id": [ { "id": "SLX4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P1D7", "type": "external" } ], "mass": 172412.0, "length": 1565, "protein_name": "Structure-specific endonuclease subunit SLX4", "gene_name": "Slx4", "organism": "Mouse", "refseq_name": "structure-specific endonuclease subunit SLX4 isoform 1", "refseq_ac": [ { "id": "NP_803423", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803423", "type": "external" } ], "gene_names_uniprotkb": "Slx4; Btbd12", "gene_names_refseq": "Btbd12; D16Bwg1016e; Slx4", "protein_names_uniprotkb": "Structure-specific endonuclease subunit SLX4; BTB/POZ domain-containing protein 12", "protein_names_refseq": "BTB/POZ domain-containing protein 12; structure-specific endonuclease subunit SLX4 isoform 1; structure-specific endonuclease subunit SLX4", "tax_id": 10090, "disease": "Fanconi-like syndrome (Disease Ontology:DOID:0090066); Fanconi anemia complementation group P (Disease Ontology:DOID:0111092)", "pathway": " (mmu:52864); (R-MMU-5693568); (R-MMU-6783310)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21240276;21655083;21750661;22911665;27010503;34428180;35941380", "class_list": "", "function": "Mouse Slx4, a regulator of structure-specific nucleases, disruption phenocopies Fanconi anemia, [RefSeq, PubMed]; Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks (By similarity)., [UniProtKB]; The structure-specific endonuclease complex SLX4-XPF regulates Tus-Ter-induced homologous recombination., [RefSeq, PubMed]; These data indicate that BTBD12 functions throughout gametogenesis to maintain genome stability, possibly by co-ordinating repair processes and/or by linking DNA repair events to the cell cycle via ATM, [RefSeq, PubMed]; This gene encodes a protein containing a BTB (POZ) domain that comprises a subunit of structure-specific endonucleases. The encoded protein aids in the resolution of DNA secondary structures that arise during the processes of DNA repair and recombination. Knock out of this gene in mouse recapitulates the phenotype of the human disease Fanconi anemia, including blood cytopenia and susceptibility to genomic instability. [provided by RefSeq, Dec 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9848, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008047 enzyme activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0070522 ERCC4-ERCC1 complex;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0000228 nuclear chromosome;GO:0048476 Holliday junction resolvase complex", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:1904431 positive regulation of t-circle formation;GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6P1D7-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BPN8-1", "uniprot_id": [ { "id": "DMXL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BPN8", "type": "external" } ], "mass": 338209.0, "length": 3032, "protein_name": "DmX-like protein 2", "gene_name": "Dmxl2", "organism": "Mouse", "refseq_name": "dmX-like protein 2 isoform X3", "refseq_ac": [ { "id": "XP_006511148", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006511148", "type": "external" } ], "gene_names_uniprotkb": "Dmxl2; Kiaa0856", "gene_names_refseq": "6330586A12; 6430411K14Rik; Dmxl2; E130119P06Rik; mKIAA0856", "protein_names_uniprotkb": "DmX-like protein 2; Rabconnectin-3", "protein_names_refseq": "dmX-like protein 2 isoform X3", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 71 (Disease Ontology:DOID:0080267); developmental and epileptic encephalopathy 81 (Disease Ontology:DOID:0112217)", "pathway": " (mmu:235380)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;22645316;25248098;25428506;27657680;31219806;33300544;40885482", "class_list": "", "function": "May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles of neuronal and endocrine homeostatic processes (By similarity). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (PubMed:25248098)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B0V2P4;Q3TNY5;Q69ZX5;Q8CCU3", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0043291 RAVE complex;GO:0098992 neuronal dense core vesicle;GO:0030672 synaptic vesicle membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007268 chemical synaptic transmission;GO:0007420 brain development;GO:0042593 glucose homeostasis;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8BPN8-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P4S6-1", "uniprot_id": [ { "id": "SIK3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P4S6", "type": "external" } ], "mass": 150659.0, "length": 1369, "protein_name": "Serine/threonine-protein kinase SIK3", "gene_name": "Sik3", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase SIK3", "refseq_ac": [ { "id": "NP_081774", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081774", "type": "external" } ], "gene_names_uniprotkb": "Sik3; Kiaa0999; Qsk", "gene_names_refseq": "5730525O22Rik; 9030204A07Rik; Qsk; SIK-3; Sik3; mKIAA0999", "protein_names_uniprotkb": "Serine/threonine-protein kinase SIK3; 2.7.11.1; SIK-3; Salt-inducible kinase 3; Serine/threonine-protein kinase QSK", "protein_names_refseq": "salt-inducible kinase 3; serine/threonine-protein kinase QSK; serine/threonine-protein kinase SIK3", "tax_id": 10090, "disease": "", "pathway": " (mmu:70661)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "17242355;21183079;21750661;22318228;22662228;24129315;25428506;30084848;32457359;33300544;39030684", "class_list": "", "function": "Impact of the SIK3 pathway inhibition on osteoclast differentiation via oxidative phosphorylation., [RefSeq, PubMed]; Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor (By similarity). Required for chondrocyte hypertrophy during skeletogenesis (PubMed:22318228). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (By similarity). Prevents HDAC4 translocation to the nucleus (PubMed:22318228)., [UniProtKB, UniProtKB, PubMed]; Results demonstrate an essential role for SIK3 in facilitating chondrocyte hypertrophy during skeletogenesis and growth plate maintenance, [RefSeq, PubMed]; SIK3 is a novel energy regulator that modulates cholesterol and bile acid metabolism by coupling with retinoid metabolism, and may alter the size of energy storage in mice., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9PU87;Q641L5;Q66JZ5;Q6ZQ09;Q8K075;Q9CYD5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0050321 tau-protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0035264 multicellular organism growth;GO:0032880 regulation of protein localization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6P4S6-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06802-1", "uniprot_id": [ { "id": "ENPP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P06802", "type": "external" } ], "mass": 103176.0, "length": 906, "protein_name": "Ectonucleotide pyrophosphatase/phosphodiesterase family member 1", "gene_name": "Enpp1", "organism": "Mouse", "refseq_name": "ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform 1", "refseq_ac": [ { "id": "NP_001295256", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295256", "type": "external" } ], "gene_names_uniprotkb": "Enpp1; Npps; Pc1; Pdnp1", "gene_names_refseq": "4833416E15Rik; CD203c; E-NPP 1; E-NPP1; Enpp1; Ly-41; M6S1; NPP1; Npps; PC-1; Pca-1; Pca; Pdnp1; ttw; twy", "protein_names_uniprotkb": "Ectonucleotide pyrophosphatase/phosphodiesterase family member 1; 3.1.4.1; 3.6.1.9; Alkaline phosphodiesterase I; E-NPP 1; Ly-41; Lymphocyte antigen 41; NPPase; Nucleotide diphosphatase; Nucleotide pyrophosphatase; Phosphodiesterase I/nucleotide pyrophosphatase 1; Plasma-cell membrane glycoprotein PC-1", "protein_names_refseq": "NPPase; alkaline phosphodiesterase I; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform 1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1; lymphocyte antigen 41; nucleotide diphosphatase; phosphodiesterase I/nucleotide pyrophosphatase 1; plasma-cell membrane glycoprotein PC-1; tiptoe walking", "tax_id": 10090, "disease": "arterial calcification of infancy (Disease Ontology:DOID:0050644); stroke (Disease Ontology:DOID:0051061); ossification of the posterior longitudinal ligament of spine (Disease Ontology:DOID:0060887); aortic valve disease 1 (Disease Ontology:DOID:0080333); otitis media (Disease Ontology:DOID:10754); spondyloarthropathy (Disease Ontology:DOID:1123); tympanosclerosis (Disease Ontology:DOID:1214); cardiovascular system disease (Disease Ontology:DOID:1287); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); glioblastoma (Disease Ontology:DOID:3068); end stage renal disease (Disease Ontology:DOID:783); osteoarthritis (Disease Ontology:DOID:8398); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18605); (R-MMU-196843)", "pathway_count": 2, "publication_count": 35, "publication_id_list": "10.1101/2023.09.13.557529;10352096;11004006;11027689;11598187;12082181;12121276;12533192;15075217;1647027;19419305;19656770;21750661;2211644;22510396;22645316;23027977;23041369;25260930;25344812;25479107;26910915;28935714;3001713;30111653;30356045;30899004;3104326;33300544;34428180;35147247;38582229;3917281;8223581;9662402", "class_list": "", "function": "Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels (PubMed:10352096, PubMed:11004006, PubMed:12082181, PubMed:22510396, PubMed:25260930, PubMed:9662402). PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals (PubMed:10352096, PubMed:11004006, PubMed:12082181, PubMed:19419305, PubMed:22510396, PubMed:25260930, PubMed:25479107, PubMed:26910915, PubMed:30111653, PubMed:35147247, PubMed:9662402). Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP and UTP to their corresponding monophosphates with release of pyrophosphate, as well as diadenosine polyphosphates, and also 3',5'-cAMP to AMP (PubMed:11027689, PubMed:1647027, PubMed:23027977, PubMed:8223581). May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling (PubMed:1647027). Inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling; it is however unclear whether hedgehog inhibition is direct or indirect (PubMed:30111653). Appears to modulate insulin sensitivity (By similarity). Also involved in melanogenesis (By similarity). Also able to hydrolyze 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production (PubMed:25344812). 2',3'-cGAMP degradation takes place in the lumen or extracellular space, and not in the cytosol where it is produced; the role of 2',3'-cGAMP hydrolysis is therefore unclear (By similarity). Not able to hydrolyze the 2',3'-cGAMP linkage isomer 3',3'-cGAMP (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; TET3 boosts hepatocyte autophagy and impairs non-alcoholic fatty liver disease by increasing ENPP1 promoter hypomethylation., [RefSeq, PubMed]; This gene encodes a member of the nucleoside pyrophosphatase/phosphodiesterase family of enzymes that catalyzes the hydrolysis of pyrophosphate and phosphodiester bonds in nucleotide triphosphates and oligonucleotides, respectively, to generate nucleoside 5'-monophosphates. The encoded protein is a type II transmembrane glycoprotein that negatively regulates bone mineralization. Mice harboring a nonsense mutation in this gene, termed tiptoe walking (ttw), exhibit ectopic ossification of the spinal ligaments. The encoded protein binds to the insulin receptor, inhibits downstream signaling events and induces insulin resistance and glucose tolerance. This gene is located adjacent to a paralog on chromosome 10. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 4, "reported_phosphosites": 2, "reported_mutagensis": 23, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 14, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q542E9;Q924C4", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.68", "type": "external" }, { "id": "3.6.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.76", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" }, { "id": "3.6.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.59", "type": "external" }, { "id": "3.6.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.52", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "3.6.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.10", "type": "external" }, { "id": "3.6.1.61", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.61", "type": "external" } ], "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0016462 pyrophosphatase activity;GO:0005044 scavenger receptor activity;GO:0005158 insulin receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:1904383 response to sodium phosphate;GO:0071344 diphosphate metabolic process;GO:0050954 sensory perception of mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 5.1, "record_id": "P06802-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV02-1", "uniprot_id": [ { "id": "RBMX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WV02", "type": "external" } ], "mass": 42301.0, "length": 391, "protein_name": "RNA-binding motif protein, X chromosome", "gene_name": "Rbmx", "organism": "Mouse", "refseq_name": "RNA-binding motif protein, X chromosome", "refseq_ac": [ { "id": "NP_001160095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160095", "type": "external" } ], "gene_names_uniprotkb": "Rbmx; Hnrnpg; Hnrpg; Rbmxp1; Rbmxrt", "gene_names_refseq": "Rbmx; hnRNP G", "protein_names_uniprotkb": "RNA-binding motif protein, X chromosome; Heterogeneous nuclear ribonucleoprotein G; hnRNP G", "protein_names_refseq": "RNA-binding motif protein, X chromosome; heterogeneous nuclear ribonucleoprotein G", "tax_id": 10090, "disease": "syndromic X-linked intellectual disability Shashi type (Disease Ontology:DOID:0060826); X-linked mental retardation Gustavson type (Disease Ontology:DOID:0081123)", "pathway": " (mmu:19655); (R-MMU-72163); (R-MMU-72203); (R-MMU-9013418); (R-MMU-9013422); (R-MMU-9696264); (R-MMU-9696270); (R-MMU-9696273); (R-MMU-9770562)", "pathway_count": 9, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10391207;17188681;19403048;21750661;24129315;26495903;31219806;33300544;34428180;35820727;36210013", "class_list": "", "function": "RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2U6;Q9R0Y0", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0014069 postsynaptic density;GO:0070062 extracellular exosome", "go_biological_process": "GO:0006509 membrane protein ectodomain proteolysis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006366 transcription by RNA polymerase II;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9WV02-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CIP5-1", "uniprot_id": [ { "id": "DISP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CIP5", "type": "external" } ], "mass": 147944.0, "length": 1345, "protein_name": "Protein dispatched homolog 2", "gene_name": "Disp2", "organism": "Mouse", "refseq_name": "protein dispatched homolog 2", "refseq_ac": [ { "id": "NP_733481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_733481", "type": "external" } ], "gene_names_uniprotkb": "Disp2; Kiaa1742", "gene_names_refseq": "B230210L08Rik; Disp2; DispB; mKIAA1742", "protein_names_uniprotkb": "Protein dispatched homolog 2", "protein_names_refseq": "dispatched B; dispatched RND tramsporter family member 2; dispatched homolog 2; protein dispatched homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:214240); (R-MMU-5362798)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12372301;21750661;24129315;25428506;30084848;34203471;34428180", "class_list": "", "function": "Dispatched plays a role in hedgehog body patterning, as demonstrated in transgenic mice, [RefSeq, PubMed]; The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q148A2;Q80T98;Q8CBA3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8CIP5-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XH1-1", "uniprot_id": [ { "id": "KXDL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80XH1", "type": "external" } ], "mass": 19977.0, "length": 177, "protein_name": "KxDL motif-containing protein 1", "gene_name": "Kxd1", "organism": "Mouse", "refseq_name": "kxDL motif-containing protein 1", "refseq_ac": [ { "id": "NP_083642", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083642", "type": "external" } ], "gene_names_uniprotkb": "Kxd1; 2810422J05Rik", "gene_names_refseq": "0610030B01Rik; 2810422J05Rik; Kxd1", "protein_names_uniprotkb": "KxDL motif-containing protein 1", "protein_names_refseq": "UPF0459 protein C19orf50 homolog; kxDL motif-containing protein 1", "tax_id": 10090, "disease": "Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": " (mmu:75620)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22554196;34428180", "class_list": "", "function": "As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity). May also be involved in the biogenesis of lysosome-related organelles such as melanosomes (PubMed:22554196)., [UniProtKB, PubMed, UniProtKB]; Component of the 60S subunit of the ribosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0098574 cytoplasmic side of lysosomal membrane;GO:0099078 BORC complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005840 ribosome", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0051036 regulation of endosome size;GO:0032418 lysosome localization;GO:0072384 organelle transport along microtubule;GO:0062196 regulation of lysosome size", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80XH1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43006-1", "uniprot_id": [ { "id": "EAA2_MOUSE", "url": "https://www.uniprot.org/uniprot/P43006", "type": "external" } ], "mass": 62030.0, "length": 572, "protein_name": "Excitatory amino acid transporter 2", "gene_name": "Slc1a2", "organism": "Mouse", "refseq_name": "excitatory amino acid transporter 2 isoform 1", "refseq_ac": [ { "id": "NP_001070982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070982", "type": "external" } ], "gene_names_uniprotkb": "Slc1a2; Eaat2; Glt1", "gene_names_refseq": "1700091C19Rik; 2900019G14Rik; Eaat2; GLT-1; GLT1; MGLT1; Slc1a2", "protein_names_uniprotkb": "Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2", "protein_names_refseq": "EAAT2 variant mEAAT2/5UT2; EAAT2 variant mEAAT2/5UT5; excitatory amino acid transporter 2 isoform 1; excitatory amino acid transporter 2; glutamate transporter 1c; sodium-dependent glutamate/aspartate transporter 2; solute carrier family 1, member 2", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); developmental and epileptic encephalopathy 41 (Disease Ontology:DOID:0080442); Alzheimer's disease (Disease Ontology:DOID:10652); opioid abuse (Disease Ontology:DOID:11206); Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289); alcohol use disorder (Disease Ontology:DOID:1574); drug psychosis (Disease Ontology:DOID:1742); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:20511); (R-MMU-210455); (R-MMU-210500); (R-MMU-9958863)", "pathway_count": 4, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;16880397;18034455;20685337;21183079;21750661;25428506;30084848;30899004;31599954;33300544;34678516;35820727;40021952;40885482;7557442;7698742;7766664;9180080;9373176", "class_list": "", "function": "Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7557442, PubMed:7698742, PubMed:9373176). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (PubMed:9180080)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 16, "disease_count": 12, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "O35877;O54686;O54687", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008509 monoatomic anion transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0005314 high-affinity L-glutamate transmembrane transporter activity;GO:0015501 glutamate:sodium symporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0098656 monoatomic anion transmembrane transport;GO:0007399 nervous system development;GO:0030534 adult behavior;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "P43006-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WC0-1", "uniprot_id": [ { "id": "SETD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WC0", "type": "external" } ], "mass": 67176.0, "length": 594, "protein_name": "Actin-histidine N-methyltransferase", "gene_name": "Setd3", "organism": "Mouse", "refseq_name": "actin-histidine N-methyltransferase isoform 2", "refseq_ac": [ { "id": "NP_082538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082538", "type": "external" } ], "gene_names_uniprotkb": "Setd3; D12Ertd771e", "gene_names_refseq": "2610102I01Rik; 2610305M23Rik; 6030490B17Rik; D12Ertd771e; Setd3", "protein_names_uniprotkb": "Actin-histidine N-methyltransferase; 2.1.1.85; Endothelial differentiation inhibitory protein D10; Protein-L-histidine N-tele-methyltransferase; SET domain-containing protein 3", "protein_names_refseq": "SET domain-containing protein 3; actin-histidine N-methyltransferase isoform 2; actin-histidine N-methyltransferase; endothelial differentiation inhibitory protein D10; histone-lysine N-methyltransferase setd3; protein-L-histidine N-tele-methyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:52690); (R-MMU-3214841)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;16008511;21750661;21832073;30626964;30796205;31527793;31654063;34428180;38334393", "class_list": "", "function": "Enterovirus pathogenesis requires the host methyltransferase SETD3. SETD3 is essential for in vivo replication and pathogenesis in multiple mouse models for EV infection, including CV-A10, EV-A71 and EV-D68., [RefSeq, PubMed]; Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30626964). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Results identify a mammalian histidine methyltransferase and uncover a pivotal role for SETD3 and actin His73 methylation in the regulation of smooth muscle contractility; data also support the broader hypothesis that protein histidine methylation acts as a common regulatory mechanism, [RefSeq, PubMed]; SETD3 is a H3K4/K36 methyltransferase and plays an important role in the transcriptional regulation of muscle cell differentiation, [RefSeq, PubMed]; SETD3 is regulated by a couple of microRNAs and plays opposing roles in proliferation and metastasis of hepatocellular carcinoma., [RefSeq, PubMed]; SETD3 regulates endoderm differentiation of mouse embryonic stem cells through canonical Wnt signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6PEN3;Q8CD86;Q8CDX8;Q9CZZ1", "ec_number_list": [ { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.370", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.370", "type": "external" }, { "id": "2.1.1.371", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.371", "type": "external" }, { "id": "2.1.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.85", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003779 actin binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0042800 histone H3K4 methyltransferase activity;GO:0046975 histone H3K36 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0051149 positive regulation of muscle cell differentiation;GO:0030047 actin modification;GO:0070472 regulation of uterine smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q91WC0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61656-1", "uniprot_id": [ { "id": "DDX5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61656", "type": "external" } ], "mass": 69290.0, "length": 614, "protein_name": "Probable ATP-dependent RNA helicase DDX5", "gene_name": "Ddx5", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ddx5; Tnz2", "gene_names_refseq": "", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX5; 3.6.4.13; DEAD box RNA helicase DEAD1; DEAD box protein 5; RNA helicase p68; mDEAD1", "protein_names_refseq": "", "tax_id": 10090, "disease": "abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); skin squamous cell carcinoma (Disease Ontology:DOID:3151)", "pathway": " (R-MMU-3899300); (R-MMU-72163); (R-MMU-9018519); (R-MMU-9770562)", "pathway_count": 4, "publication_count": 27, "publication_id_list": "17011493;17960593;19723804;20173027;21750661;22570411;22767893;23806337;25428506;25605945;28011936;28528544;28935714;30084848;30779550;33300544;33649389;33725478;34203471;34418053;34428180;34887587;35820727;36288343;37453647;39627609;8445986", "class_list": "", "function": "Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9Q105", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" } ], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0007623 circadian rhythm;GO:0030509 BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q61656-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTZ9-1", "uniprot_id": [ { "id": "BEX3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTZ9", "type": "external" } ], "mass": 14542.0, "length": 124, "protein_name": "Protein BEX3", "gene_name": "Bex3", "organism": "Mouse", "refseq_name": "protein BEX3 isoform a", "refseq_ac": [ { "id": "NP_001103703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103703", "type": "external" } ], "gene_names_uniprotkb": "Bex3; Nade; Ngfrap1", "gene_names_refseq": "Bex3; DXWsu67e; Gcap27; Nade; Ngfrap1", "protein_names_uniprotkb": "Protein BEX3; Brain-expressed X-linked protein 3 homolog; Nerve growth factor receptor-associated protein 1; p75NTR-associated cell death executor", "protein_names_refseq": "brain-expressed X-linked protein 3 homolog; granule cell antiserum positive 27; nerve growth factor receptor (TNFRSF16) associated protein 1; nerve growth factor receptor-associated protein 1; p75NTR-associated Cell Death Executor; protein BEX3 isoform a; protein BEX3", "tax_id": 10090, "disease": "glaucoma (Disease Ontology:DOID:1686); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (mmu:12070); (R-MMU-205025)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10072429;10764727;11278287;11830582;12935912;15178455;15563833;33100228;34428180;34562363", "class_list": "", "function": "Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions. Publication Status: Online-Only, [RefSeq, PubMed]; May be a signaling adapter molecule involved in NGFR/p75NTR-mediated apoptosis induced by NGF (PubMed:10764727). Plays a role in zinc-triggered neuronal death (PubMed:10764727). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (PubMed:34562363)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KGA0;A3KGA1;Q9CWN9;Q9D0S2;Q9D1N5", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005163 nerve growth factor receptor binding;GO:0005123 death receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction;GO:0031397 negative regulation of protein ubiquitination;GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9WTZ9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZL9-1", "uniprot_id": [ { "id": "DKKL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZL9", "type": "external" } ], "mass": 26639.0, "length": 230, "protein_name": "Dickkopf-like protein 1", "gene_name": "Dkkl1", "organism": "Mouse", "refseq_name": "dickkopf-like protein 1 precursor", "refseq_ac": [ { "id": "NP_056604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056604", "type": "external" } ], "gene_names_uniprotkb": "Dkkl1; Sgy1", "gene_names_refseq": "Dkkl1; SGY-1; SGY1; SGY; Soggy; mSgy", "protein_names_uniprotkb": "Dickkopf-like protein 1; Protein soggy-1; SGY-1", "protein_names_refseq": "dickkopf-like protein 1 precursor; dickkopf-like protein 1; protein soggy-1; soggy 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:50722)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10570958;11024178;14966277;15892050;18818293;19176879;19596310;19596312;21698294;21750661;22817830;27550540", "class_list": "", "function": "Involved in fertilization by facilitating sperm penetration of the zona pellucida (PubMed:19596312, PubMed:22817830). May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells (PubMed:18818293). Is not essential either for development or fertility (PubMed:19596310)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Results suggest that DNA methylation is not the primary determinant of Soggy/Tead2 expression., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQT4;Q9ERW0;Q9ERW1", "ec_number_list": [], "go_molecular_function": "GO:0048019 receptor antagonist activity;GO:0039706 co-receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0045600 positive regulation of fat cell differentiation;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0060070 canonical Wnt signaling pathway;GO:0007341 penetration of zona pellucida", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9QZL9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WW9-1", "uniprot_id": [ { "id": "DDRGK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80WW9", "type": "external" } ], "mass": 35977.0, "length": 315, "protein_name": "DDRGK domain-containing protein 1", "gene_name": "Ddrgk1", "organism": "Mouse", "refseq_name": "DDRGK domain-containing protein 1 isoform a", "refseq_ac": [ { "id": "NP_084108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084108", "type": "external" } ], "gene_names_uniprotkb": "Ddrgk1; Ufbp1", "gene_names_refseq": "1110001I20Rik; 2600009E05Rik; Ddrgk1; Ufbp1", "protein_names_uniprotkb": "DDRGK domain-containing protein 1; UFM1-binding and PCI domain-containing protein 1", "protein_names_refseq": "DDRGK domain-containing protein 1 isoform a; DDRGK domain-containing protein 1; UFM1-binding and PCI domain-containing protein 1; UFM1-binding protein 1 containing a PCI domain", "tax_id": 10090, "disease": "", "pathway": " (mmu:77006); (R-MMU-8980692)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "20228063;21494687;21750661;25428506;26544067;28128204;28263186;30701081;30842412;31219806;37086384;37566002;37781516;37795761;38233375", "class_list": "", "function": "Component of the UFM1 ribosome E3 ligase (UREL) complex, a multiprotein complex that catalyzes ufmylation of endoplasmic reticulum-docked proteins (PubMed:30701081, PubMed:37795761). The UREL complex plays a key role in ribosome recycling by mediating mono-ufmylation of the RPL26/uL24 subunit of the 60S ribosome following ribosome dissociation: ufmylation weakens the junction between post-termination 60S subunits and SEC61 translocons, promoting release and recycling of the large ribosomal subunit from the endoplasmic reticulum membrane (By similarity). Ufmylation of RPL26/uL24 and subsequent 60S ribosome recycling either take place after normal termination of translation or after ribosome stalling during cotranslational translocation at the endoplasmic reticulum (By similarity). Within the UREL complex, DDRGK1 tethers the complex to the endoplasmic reticulum membrane to restrict its activity to endoplasmic reticulum-docked ribosomes and acts as an ufmylation 'reader': following RPL26/uL24 ufmylation, DDRGK1 specifically binds to ufmylated RPL26/uL24 via its UFIM motif, resulting in stable association between the 60S ribosome and the UREL complex, followed by dissociation of the 60S ribosome subunit from the endoplasmic reticulum membrane (By similarity). The UREL complex is also involved in reticulophagy in response to endoplasmic reticulum stress by promoting ufmylation of proteins such as CYB5R3 and RPN1, thereby promoting lysosomal degradation of ufmylated proteins (By similarity). Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) by regulating ERN1/IRE1-alpha stability (PubMed:28128204). Acts as a regulator of immunity by promoting differentiation of B-cells into plasma cells: acts by promoting expansion of the endoplasmic reticulum and regulating the unfolded protein response (UPR) (PubMed:30842412). May also be required for TRIP4 ufmylation (By similarity). May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B (PubMed:28263186). Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator (PubMed:28263186). Required for stabilization and ufmylation of ATG9A (PubMed:37086384)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; DDRGK1-mediated ER-phagy attenuates acute kidney injury through ER-stress and apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of DDRGK1 impairs IRE1alpha UFMylation in spondyloepiphyseal dysplasia. Publication Status: Online-Only, [RefSeq, PubMed]; These data suggest that UFM1-UFBP1 participate in preventing endoplasmic reticulum stress-induced apoptosis in protein secretory cells. Publication Status: Online-Only, [RefSeq, PubMed]; Ufmylation of UFBP1 Is Dispensable for Endoplasmic Reticulum Stress Response, Embryonic Development, and Cardiac and Intestinal Homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14BT4;Q9CT52", "ec_number_list": [], "go_molecular_function": "GO:0044389 ubiquitin-like protein ligase binding;GO:0141185 UFM1-modified protein reader activity", "go_cellular_component": "GO:1990234 transferase complex;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q80WW9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UH60-1", "uniprot_id": [ { "id": "DIP2B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UH60", "type": "external" } ], "mass": 171126.0, "length": 1574, "protein_name": "Disco-interacting protein 2 homolog B", "gene_name": "Dip2b", "organism": "Mouse", "refseq_name": "disco-interacting protein 2 homolog B isoform 1", "refseq_ac": [ { "id": "NP_001152833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152833", "type": "external" } ], "gene_names_uniprotkb": "Dip2b; Kiaa1463", "gene_names_refseq": "4932422C22; Dip2b; mKIAA1463", "protein_names_uniprotkb": "Disco-interacting protein 2 homolog B; DIP2 homolog B", "protein_names_refseq": "DIP2 disco-interacting protein 2 homolog B; DIP2 homolog B; disco-interacting protein 2 homolog B isoform 1", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder type FRA12A (Disease Ontology:DOID:0061049)", "pathway": " (mmu:239667)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19144319;21183079;31219806;32153366;34208944;34428180;35091337;37705068;40885482", "class_list": "", "function": "Analysis of Dip2B Expression in Adult Mouse Tissues Using the LacZ Reporter Gene. Publication Status: Online-Only, [RefSeq, PubMed]; Heterozygous loss of Dip2B enhances tumor growth and metastasis by altering immune microenvironment., [RefSeq, PubMed]; Loss of Dip2b leads to abnormal neural differentiation from mESCs. Publication Status: Online-Only, [RefSeq, PubMed]; Negatively regulates axonal outgrowth and is essential for normal synaptic transmission (PubMed:32153366). Not required for regulation of axon polarity (PubMed:32153366). Promotes acetylation of alpha-tubulin (PubMed:32153366)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1W5;Q8CDG9;Q8CHA2", "ec_number_list": [], "go_molecular_function": "GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030424 axon;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:0007399 nervous system development;GO:0030517 negative regulation of axon extension;GO:2000758 positive regulation of peptidyl-lysine acetylation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q3UH60-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6Q899-1", "uniprot_id": [ { "id": "RIGI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6Q899", "type": "external" } ], "mass": 105975.0, "length": 926, "protein_name": "Antiviral innate immune response receptor RIG-I", "gene_name": "Rigi", "organism": "Mouse", "refseq_name": "antiviral innate immune response receptor RIG-I", "refseq_ac": [ { "id": "NP_766277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766277", "type": "external" } ], "gene_names_uniprotkb": "Rigi; Ddx58", "gene_names_refseq": "6430573D20Rik; C330021E21; Ddx58; RIG-I; RLR-1; Rigi", "protein_names_uniprotkb": "Antiviral innate immune response receptor RIG-I; 3.6.4.13; ATP-dependent RNA helicase DDX58; DEAD box protein 58; RIG-1; RIG-I-like receptor 1; RIG-I; RLR-1; RNA sensor RIG-I; Retinoic acid-inducible gene 1 protein; Retinoic acid-inducible gene I protein", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; DEAD box protein 58; DEAD/H box helicase 58; DEAD/H box polypeptide RIG-I; RIG-1; RIG-I-like receptor 1; antiviral innate immune response receptor RIG-I; probable ATP-dependent RNA helicase DDX58; retinoic acid-inducible gene 1 protein; retinoic acid-inducible gene I protein; retinoic acid-inducible gene-I", "tax_id": 10090, "disease": "Fanconi anemia (Disease Ontology:DOID:13636)", "pathway": " (mmu:230073); (R-MMU-1169408); (R-MMU-5689880); (R-MMU-8983711); (R-MMU-936440); (R-MMU-9909505)", "pathway_count": 6, "publication_count": 19, "publication_id_list": "16039576;16116171;16210631;16625202;17942531;19576794;19609254;19631370;20950133;21175414;21496944;21616437;21750661;21884169;21979817;22645316;23374343;29259080;34428180", "class_list": "", "function": "Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons. Ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Sendai virus (SeV), Rhabdoviridae and Flaviviridae. It also detects rotavirus and orthoreovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome. Detects dsRNA produced from non-self dsDNA by RNA polymerase III. May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Lgp2 acts as a negative feedback regulator of antiviral signaling by sequestering double-stranded RNA from retinoic acid-inducible gene-I (RIG-I)., [RefSeq, PubMed]; RIG-I is essential for induction of type I interferons (IFNs) after infection with RNA viruses in fibroblasts and conventional dendritic cells (DCs)., [RefSeq, PubMed]; Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AP28;Q8C320;Q8C5I3;Q8C7T2", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.4.26.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.26.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "6.3.2.n3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.n3", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0032727 positive regulation of interferon-alpha production;GO:0060760 positive regulation of response to cytokine stimulus;GO:0010628 positive regulation of gene expression;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q6Q899-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JY0-1", "uniprot_id": [ { "id": "ECHB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JY0", "type": "external" } ], "mass": 51386.0, "length": 475, "protein_name": "Trifunctional enzyme subunit beta, mitochondrial", "gene_name": "Hadhb", "organism": "Mouse", "refseq_name": "trifunctional enzyme subunit beta, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001276727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276727", "type": "external" } ], "gene_names_uniprotkb": "Hadhb", "gene_names_refseq": "4930479F15Rik; Hadhb; Mtpb; TP-beta", "protein_names_uniprotkb": "Trifunctional enzyme subunit beta, mitochondrial; 3-oxoacyl-CoA thiolase; Acetyl-CoA acyltransferase; Beta-ketothiolase; LCKAT; Long chain 3-ketoacyl-CoA thiolase; TP-beta", "protein_names_refseq": "hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta aubunit; hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit; trifunctional enzyme subunit beta, mitochondrial precursor; trifunctional enzyme subunit beta, mitochondrial", "tax_id": 10090, "disease": "mitochondrial trifunctional protein deficiency 2 (Disease Ontology:DOID:0060999); mitochondrial trifunctional protein deficiency (Disease Ontology:DOID:0111277); Alzheimer's disease (Disease Ontology:DOID:10652); lipid metabolism disorder (Disease Ontology:DOID:3146); mitochondrial metabolism disease (Disease Ontology:DOID:700); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:231086); (R-MMU-1482798); (R-MMU-77285); (R-MMU-77305); (R-MMU-77310); (R-MMU-77346); (R-MMU-77348); (R-MMU-77350)", "pathway_count": 8, "publication_count": 18, "publication_id_list": "21750661;23576753;23806337;25428506;25605945;26495903;26740625;28011936;29949755;31599954;32513690;34428180;35820727;36288343;37453647;37507081;39627609;39927985", "class_list": "", "function": "A long noncoding RNA regulates inflammation resolution by mouse macrophages through fatty acid oxidation activation., [RefSeq, PubMed]; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through cycles of four consecutive reactions. Each beta-oxidation cycle shortens the fatty acyl-CoA by two carbons, yielding one acetyl-CoA (for the citric acid cycle), one FADH(2), and one NADH (which donate electrons to the respiratory chain for ATP production). These cycles repeat until the chain is fully degraded to acetyl-CoA units. Among the enzymes involved in this pathway, the trifunctional protein, responsible for the hydration, dehydrogenation, and thiolysis steps, shows specificity for long-chain fatty acids, such as those from dietary and stored fats. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity. These activities have been experimentally confirmed on a few substrates derived from beta-oxidation of long-chain saturated fatty acids such as palmitate (hexadecanoate) and laurate (dodecanoate). In addition, based on its established catalytic mechanism, and combined genetic interaction or mutant phenotype evidence, it is predicted to act also on other substrates, including long-chain unsaturated fatty acids such as oleate (9Z-octadecenoate), linoleate (9Z,12Z-octadecadienoate), linolenate (9Z,12Z,15Z-octadecatrienoate), and others., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEH9;Q8BJI5;Q8BJM0;Q8BK52", "ec_number_list": [ { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" } ], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0003988 acetyl-CoA C-acyltransferase activity;GO:0003985 acetyl-CoA C-acetyltransferase activity;GO:0050633 acetyl-CoA C-myristoyltransferase activity;GO:0106222 lncRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0071222 cellular response to lipopolysaccharide;GO:0010467 gene expression;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q99JY0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56564-1", "uniprot_id": [ { "id": "EAA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P56564", "type": "external" } ], "mass": 59622.0, "length": 543, "protein_name": "Excitatory amino acid transporter 1", "gene_name": "Slc1a3", "organism": "Mouse", "refseq_name": "excitatory amino acid transporter 1", "refseq_ac": [ { "id": "NP_683740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_683740", "type": "external" } ], "gene_names_uniprotkb": "Slc1a3; Eaat1; Gmt1", "gene_names_refseq": "B430115D02Rik; Eaat1; GLAST-1; GLAST; GLU-T; GluT-1; Gmt1; MGluT1; Slc1a3", "protein_names_uniprotkb": "Excitatory amino acid transporter 1; GLAST-1; Glial high affinity glutamate transporter; GluT-1; High-affinity neuronal glutamate transporter; Sodium-dependent glutamate/aspartate transporter 1; Solute carrier family 1 member 3", "protein_names_refseq": "excitatory amino acid transporter 1; glial high affinity glutamate transporter; glutamate/aspartate transporter; high-affinity neuronal glutamate transporter; sodium-dependent glutamate/aspartate transporter 1; solute carrier family 1, member 3", "tax_id": 10090, "disease": "episodic ataxia type 6 (Disease Ontology:DOID:0050994); neurodegenerative disease (Disease Ontology:DOID:1289); low tension glaucoma (Disease Ontology:DOID:13544); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:20512); (R-MMU-210455); (R-MMU-210500); (R-MMU-9958863)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;15363892;15390100;16880397;17114649;19656770;21183079;21750661;28032905;30084848;33300544;7903437", "class_list": "", "function": "Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:28032905, PubMed:7903437). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (PubMed:15363892, PubMed:15390100, PubMed:16880397)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q99P53", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016597 amino acid binding;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0005314 high-affinity L-glutamate transmembrane transporter activity;GO:0015501 glutamate:sodium symporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0021545 cranial nerve development;GO:0031223 auditory behavior;GO:0050885 neuromuscular process controlling balance;GO:0009611 response to wounding;GO:0006883 intracellular sodium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P56564-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35459-1", "uniprot_id": [ { "id": "ECH1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35459", "type": "external" } ], "mass": 36118.0, "length": 327, "protein_name": "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial", "gene_name": "Ech1", "organism": "Mouse", "refseq_name": "delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_058052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058052", "type": "external" } ], "gene_names_uniprotkb": "Ech1", "gene_names_refseq": "Ech1", "protein_names_uniprotkb": "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial; 5.3.3.21", "protein_names_refseq": "delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial precursor; delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial; peroxisomal/mitochondrial dienoyl-CoA isomerase", "tax_id": 10090, "disease": "", "pathway": " (mmu:51798); (R-MMU-9033241); (R-MMU-9837999)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "14500732;19892989;21616630;21750661;22336209;23576753;23806337;25428506;25605945;27802388;30084848;30779550;31219806;31961704;33813878;34428180;35820727;36210013;36288343;37507081", "class_list": "", "function": "Auxiliary enzyme in the beta-oxidation of mono- and polyunsaturated fatty acids. Together with the 2,4-dienoyl-CoA reductase (DECR) and the Enoyl-CoA delta isomerase 1 (ECI1) they allow reentrance of the enoyl-CoA into the beta-oxidation cycle (By similarity). Able to isomerize 3-trans,5-cis-dienoyl-CoA (3E,5Z-dienoyl-CoA) to 2-trans,4-trans-dienoyl-CoA (2E,4E-dienoyl-CoA), a crucial step in the beta-oxidation of unsaturated fatty acids with double bonds at odd position (By similarity). Based on its established catalytic mechanism, it is predicted to act also on other fatty acids besides those tested experimentally (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Disruption of peroxisomal fatty acid beta-oxidation at the level of enoyl-CoA hydratase/L-3-hydroxyacyl-CoA dehydrogenase (L-PBE) in mice leads to the induction of many of the PPARalpha target genes independently of peroxisome proliferation in hepatocytes, [RefSeq, PubMed]; Down-regulation of ECH1 could inhibit the cell proliferation and migration of Hca-F hepatocarcinoma cells., [RefSeq, PubMed]; ECH1 regulated the thermogenic program by inhibiting mammalian target of rapamycin signaling, which may partially explain the potential mechanism for ECH1 regulating adipose browning, [RefSeq, PubMed]; Enoyl coenzyme A hydratase 1 alleviates nonalcoholic steatohepatitis in mice by suppressing hepatic ferroptosis., [RefSeq, PubMed]; The downregulation of Ech1 inhibited proliferation of the Hca-F cells, increased the ratio of Hca-F cells in S phase to G(1) phase and decreased the adhesion and migration capacities of Hca-F cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5M8P6", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0051750 delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity;GO:0016853 isomerase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome", "go_biological_process": "GO:0006635 fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "O35459-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54693-1", "uniprot_id": [ { "id": "EDA_MOUSE", "url": "https://www.uniprot.org/uniprot/O54693", "type": "external" } ], "mass": 41603.0, "length": 391, "protein_name": "Ectodysplasin-A", "gene_name": "Eda", "organism": "Mouse", "refseq_name": "ectodysplasin-A isoform 2", "refseq_ac": [ { "id": "NP_001171408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171408", "type": "external" } ], "gene_names_uniprotkb": "Eda; Ed1; Ta", "gene_names_refseq": "EDA1; Ed1; Eda-A1; Eda-A2; Eda; HED; Ta; Tnlg7c; XLHED; tabby", "protein_names_uniprotkb": "Ectodysplasin-A; EDA protein homolog; Tabby protein", "protein_names_refseq": "EDA protein homolog; ectodysplasin-A isoform 2; tumor necrosis factor ligand 7c", "tax_id": 10090, "disease": "tooth agenesis (Disease Ontology:DOID:0050591); ectodermal dysplasia 1 (Disease Ontology:DOID:0111664); hypohidrotic ectodermal dysplasia (Disease Ontology:DOID:14793); carcinoma (Disease Ontology:DOID:305)", "pathway": " (mmu:13607); (R-MMU-5669034)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10534613;9285798;9371801", "class_list": "", "function": "Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform TAA binds only to the receptor EDAR, while isoform TA-A2 binds exclusively to the receptor EDA2R (By similarity). May also play a role in cell adhesion (PubMed:10534613)., [UniProtKB, UniProtKB, PubMed]; Isoform TA-A2 binds exclusively to the receptor EDA2R., [UniProtKB, UniProtKB]; Isoform TAA binds only to the receptor EDAR, while isoform TA-A2 binds exclusively to the receptor EDA2R., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B7ZMT7;O35705;Q9QWJ8;Q9QZ01;Q9QZ02", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005125 cytokine activity;GO:0038177 death receptor agonist activity;GO:0005123 death receptor binding;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005811 lipid droplet;GO:0005886 plasma membrane;GO:0045177 apical part of cell;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006955 immune response;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O54693-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DN83-1", "uniprot_id": [ { "id": "DWORF_MOUSE", "url": "https://www.uniprot.org/uniprot/P0DN83", "type": "external" } ], "mass": 3815.0, "length": 34, "protein_name": "Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF", "gene_name": "Strit1", "organism": "Mouse", "refseq_name": "sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF isoform 2", "refseq_ac": [ { "id": "NP_001356235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001356235", "type": "external" } ], "gene_names_uniprotkb": "Strit1", "gene_names_refseq": "DWORF; Gm34302; Strit1", "protein_names_uniprotkb": "Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF; DWORF; Dwarf open reading frame; SERCA regulator DWORF; Small transmembrane regulator of ion transport 1", "protein_names_refseq": "SERCA regulator DWORF; Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF; sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF isoform 2", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "26816378;30299255;31449798;35605666;38334971", "class_list": "", "function": "Deletion of DWORF does not affect cardiac function in aging and in PLN-R14del cardiomyopathy., [RefSeq, PubMed]; Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity (PubMed:26816378, PubMed:30299255). Also enhances the activity of the ATP2A2/SERCA2 ATPase (By similarity). Does not directly stimulate SERCA pump activity (PubMed:26816378). Binds preferentially to the phosphorylated E1 and E2 conformational forms of ATP2A2 which predominate at high Ca(2+) concentrations during the systolic phase of the cardiac cycle (PubMed:35605666). Competes with ATP2A2 inhibitor phospholamban (PLN) for binding to ATP2A2 and displaces PLN (By similarity). Can activate ATP2A2 directly in the absence of PLN (By similarity). Also enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN) and myoregulin (MRLN) (PubMed:26816378, PubMed:30299255)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Here the show that DWORF has a higher apparent binding affinity for SERCA than PLN and that DWORF overexpression mitigates the contractile dysfunction associated with PLN overexpression, substantiating its role as a potent activator of SERCA. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0016529 sarcoplasmic reticulum;GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:0031449 regulation of slow-twitch skeletal muscle fiber contraction;GO:1901894 regulation of ATPase-coupled calcium transmembrane transporter activity;GO:1902082 positive regulation of calcium ion import into sarcoplasmic reticulum;GO:0090280 positive regulation of calcium ion import;GO:1901896 positive regulation of ATPase-coupled calcium transmembrane transporter activity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0DN83-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62869-1", "uniprot_id": [ { "id": "ELOB_MOUSE", "url": "https://www.uniprot.org/uniprot/P62869", "type": "external" } ], "mass": 13170.0, "length": 118, "protein_name": "Elongin-B", "gene_name": "Elob", "organism": "Mouse", "refseq_name": "elongin-B", "refseq_ac": [ { "id": "NP_080581", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080581", "type": "external" } ], "gene_names_uniprotkb": "Elob; Tceb2", "gene_names_refseq": "0610040H15Rik; Elob; Tceb2", "protein_names_uniprotkb": "Elongin-B; EloB; Elongin 18 kDa subunit; RNA polymerase II transcription factor SIII subunit B; SIII p18; Transcription elongation factor B polypeptide 2", "protein_names_refseq": "RNA polymerase II transcription factor SIII subunit B; SIII p18; elongin 18 kDa subunit; elongin-B; transcription elongation factor B (SIII), polypeptide 2 (18 kDa, elongin B); transcription elongation factor B polypeptide 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67673); (R-MMU-112382); (R-MMU-1234176); (R-MMU-674695); (R-MMU-6796648); (R-MMU-75955); (R-MMU-8951664); (R-MMU-9705462); (R-MMU-983168); (R-MMU-9954709)", "pathway_count": 10, "publication_count": 14, "publication_id_list": "10051596;11384984;16498413;21183079;21750661;23897481;27863225;27863226;30811962;31219806;33590678;34428180;35978186;37828378", "class_list": "", "function": "Core component of multiple cullin-2 and cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes), which mediate the ubiquitination of target proteins (PubMed:33590678, PubMed:35978186). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes (By similarity). Component the von Hippel-Lindau ubiquitination complex CBC(VHL) (By similarity). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The ECS(ASB9) complex mediates ubiquitination and degradation of CKB (By similarity). As part of a multisubunit ubiquitin ligase complex, polyubiquitinates monoubiquitinated POLR2A (By similarity). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (PubMed:33590678). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (By similarity). The ECS(ASB7) complex acts a negative regulator of H3K9me3 histone mark by mediating ubiquitination and degradation of SUV39H1 (By similarity). As part of the ECS(LRRC58) complex, mediates CDO1 ubiquitination and degradation, regulating cysteine catabolism (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Crystal structure shows interaction between SOCS2-elongin BC and Cullin-5., [RefSeq, PubMed]; EPOP (E130012A19Rik) functionally links elongin B, elongin C, and polycomb in pluripotent stem cells., [RefSeq, PubMed]; EPOP (E130012A19Rik) interacts with elongin B, elongin C, and USP7 to modulate the chromatin landscape. Erratum:[Mol Cell. 2017 Jan 5;65(1):202. doi: 10.1016/j.molcel.2016.12.006. PMID: 28061330], [RefSeq, PubMed]; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites (By similarity). Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (PubMed:27863225, PubMed:27863226)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]; These findings suggest that post-transcriptional regulation of Elongin B occurs in the testis, which is a common phenomenon during male germ cell development. As a major binding partner of SPAG16S, Elongin B may play an important role in spermatogenesis by modulating RNA maturation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63529;Q80W20", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0030891 VCB complex;GO:0005829 cytosol;GO:0005667 transcription regulator complex;GO:0031462 Cul2-RING ubiquitin ligase complex;GO:0031466 Cul5-RING ubiquitin ligase complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0016567 protein ubiquitination;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P62869-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05BC3-1", "uniprot_id": [ { "id": "EMAL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q05BC3", "type": "external" } ], "mass": 89680.0, "length": 814, "protein_name": "Echinoderm microtubule-associated protein-like 1", "gene_name": "Eml1", "organism": "Mouse", "refseq_name": "echinoderm microtubule-associated protein-like 1 isoform 1", "refseq_ac": [ { "id": "NP_001036800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036800", "type": "external" } ], "gene_names_uniprotkb": "Eml1", "gene_names_refseq": "1110008N23Rik; A930030P13Rik; ELP79; EMAP-1; EMAPL; EMAP; Eml1; heco", "protein_names_uniprotkb": "Echinoderm microtubule-associated protein-like 1; EMAP-1", "protein_names_refseq": "echinoderm microtubule associated protein-like protein 1; echinoderm microtubule-associated protein-like 1 isoform 1", "tax_id": 10090, "disease": "subcortical band heterotopia (Disease Ontology:DOID:0111169); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); epilepsy (Disease Ontology:DOID:1826); congenital nervous system abnormality (Disease Ontology:DOID:2490); skin melanoma (Disease Ontology:DOID:8923)", "pathway": " (mmu:68519)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "21750661;22645316;22872234;24859200;31112734;34203471;34428180;35190581;35822049;36288343;40021952;40885482", "class_list": "", "function": "EML1 is essential for retinal photoreceptor migration and survival. Publication Status: Online-Only, [RefSeq, PubMed]; Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q05AF8;Q0P5V3", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005874 microtubule;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007420 brain development;GO:0000226 microtubule cytoskeleton organization;GO:0002244 hematopoietic progenitor cell differentiation;GO:0007405 neuroblast proliferation;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q05BC3-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64355-1", "uniprot_id": [ { "id": "EFS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64355", "type": "external" } ], "mass": 58973.0, "length": 560, "protein_name": "Embryonal Fyn-associated substrate", "gene_name": "Efs", "organism": "Mouse", "refseq_name": "embryonal Fyn-associated substrate isoform 1", "refseq_ac": [ { "id": "NP_034242", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034242", "type": "external" } ], "gene_names_uniprotkb": "Efs; Sin", "gene_names_refseq": "Efs", "protein_names_uniprotkb": "Embryonal Fyn-associated substrate; SRC-interacting protein; Signal-integrating protein", "protein_names_refseq": "SRC-interacting protein; embryonal Fyn-associated substrate isoform 1; signal-integrating protein", "tax_id": 10090, "disease": "Crohn's disease (Disease Ontology:DOID:8778)", "pathway": " (mmu:13644)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;34428180;8570184;8647432", "class_list": "", "function": "Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BSX4", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005925 focal adhesion", "go_biological_process": "GO:0007155 cell adhesion;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q64355-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH95-1", "uniprot_id": [ { "id": "ECHM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH95", "type": "external" } ], "mass": 31474.0, "length": 290, "protein_name": "Enoyl-CoA hydratase, mitochondrial", "gene_name": "Echs1", "organism": "Mouse", "refseq_name": "enoyl-CoA hydratase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_444349", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444349", "type": "external" } ], "gene_names_uniprotkb": "Echs1", "gene_names_refseq": "Echs1; SCEH; mECH1; mECH", "protein_names_uniprotkb": "Enoyl-CoA hydratase, mitochondrial; 4.2.1.17; 5.3.3.8; ECHS1; Enoyl-CoA hydratase 1; SCEH; Short-chain enoyl-CoA hydratase; mECH1; mECH", "protein_names_refseq": "enoyl-CoA hydratase 1; enoyl-CoA hydratase, mitochondrial precursor; enoyl-CoA hydratase, mitochondrial; short-chain enoyl-CoA hydratase", "tax_id": 10090, "disease": "mitochondrial short-chain enoyl-CoA hydratase 1 deficiency (Disease Ontology:DOID:0070540); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (mmu:93747); (R-MMU-70895); (R-MMU-77310); (R-MMU-77346); (R-MMU-77348); (R-MMU-77350); (R-MMU-77352)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "21722304;23576753;23806337;34428180;35820727;36288343;37453647;37507081;39927985", "class_list": "", "function": "Converts unsaturated trans-2-enoyl-CoA species ((2E)-enoyl-CoA) to the corresponding (3S)-3-hydroxyacyl-CoA species through addition of a water molecule to the double bond. Catalyzes the hydration of medium- and short-chained fatty enoyl-CoA thioesters from 4 carbons long (C4) up to C16 (By similarity). Has high substrate specificity for crotonyl-CoA ((2E)-butenoyl-CoA) and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA) and methacrylyl-CoA ((2E)-2-methylpropenoyl-CoA). Can bind tiglyl-CoA (2-methylcrotonoyl-CoA), but hydrates only a small amount of this substrate (By similarity). Plays a key role in the beta-oxidation spiral of short- and medium-chain fatty acid oxidation. At a lower rate than the hydratase reaction, catalyzes the isomerase reaction of trans-3-enoyl-CoA species (such as (3E)-hexenoyl-CoA) to trans-2-enoyl-CoA species (such as (2E)-hexenoyl-CoA), which are subsequently hydrated to 3(S)-3-hydroxyacyl-CoA species (such as (3S)-hydroxyhexanoyl-CoA) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Potential protein targets for the loss of PostC may include F(1)-ATPase gamma, Echs1 and Hsp20 that could regulate cellular ATP consumption/production and defense response to ischaemic stress, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJK2;Q6GQS2;Q6PEN1;Q99LX7", "ec_number_list": [ { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "1.1.1.211", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.211", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "4.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.18", "type": "external" }, { "id": "4.2.1.56", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.56", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0004300 enoyl-CoA hydratase activity;GO:0004165 delta(3)-delta(2)-enoyl-CoA isomerase activity;GO:0120092 (2E)-butenoyl-CoA hydratase activity;GO:0043956 3-hydroxypropionyl-CoA dehydratase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0006574 L-valine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BH95-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHL5-1", "uniprot_id": [ { "id": "ELMO2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHL5", "type": "external" } ], "mass": 83887.0, "length": 732, "protein_name": "Engulfment and cell motility protein 2", "gene_name": "Elmo2", "organism": "Mouse", "refseq_name": "engulfment and cell motility protein 2 isoform 3", "refseq_ac": [ { "id": "NP_001289681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289681", "type": "external" } ], "gene_names_uniprotkb": "Elmo2; Kiaa1834", "gene_names_refseq": "1190002F24Rik; CED-12; Elmo2", "protein_names_uniprotkb": "Engulfment and cell motility protein 2; Protein ced-12 homolog A", "protein_names_refseq": "CED-12 homolog A; engulfment and cell motility protein 2 isoform 3; engulfment and cell motility protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:140579); (R-MMU-2029482); (R-MMU-4420097); (R-MMU-8849471); (R-MMU-9013408)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "11595183;15592455;17947660;18034455;19439446;21750661;25428506;25533347;25572395;25605945;30084848;30604775;30779550;31599954;32651375;34428180", "class_list": "", "function": "Collectively, our studies demonstrate that formation of an Elmo2.ClipR-59 complex plays an important role in myoblast fusion., [RefSeq, PubMed]; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1., [UniProtKB, UniProtKB]; Regulates the activity of DOCK guanine nucleotide exchange factors (GEFs). Acts in association with DOCK1, DOCK2, DOCK4 and CRK. Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility., [UniProtKB, UniProtKB]; Resutls show that the interaction with ELMO2 and RhoG is essential for the ability of ILK to induce front-rear cell polarity., [RefSeq, PubMed]; Study demonstrated that an evolutionarily conserved fragment in the C-terminal cytoplasmic tail of BAI-aGPCRs is specifically recognized by the RBD-ARR-ELMO (RAE) supramodule of the ELMO family scaffolds. The crystal structures of ELMO2-RAE and its complex with BAI1 uncover the molecular basis of BAI/ELMO interactions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A5A6;Q5GMG3;Q8BHL9;Q8BQG1;Q8CBM8;Q8CC50;Q8CH98;Q91ZU2;Q9CT75", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0006909 phagocytosis;GO:0006915 apoptotic process;GO:0060326 cell chemotaxis;GO:0048870 cell motility", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8BHL5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BPU7-1", "uniprot_id": [ { "id": "ELMO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BPU7", "type": "external" } ], "mass": 83936.0, "length": 727, "protein_name": "Engulfment and cell motility protein 1", "gene_name": "Elmo1", "organism": "Mouse", "refseq_name": "engulfment and cell motility protein 1 isoform 3", "refseq_ac": [ { "id": "NP_525027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525027", "type": "external" } ], "gene_names_uniprotkb": "Elmo1", "gene_names_refseq": "6330578D22Rik; C230095H21Rik; CED-12; Elmo1", "protein_names_uniprotkb": "Engulfment and cell motility protein 1; Protein ced-12 homolog", "protein_names_refseq": "engulfment and cell motility 1, ced-12 homolog; engulfment and cell motility protein 1 isoform 3; engulfment and cell motility protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:140580); (R-MMU-2029482); (R-MMU-4420097); (R-MMU-8849471); (R-MMU-9958810)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11595183;17960134;21183079;21750661;26205662;27505886;29187734;30084848;31219806;34428180;36210013;36694274;37175809", "class_list": "", "function": "ELMO1 Deficiency Reduces Neutrophil Chemotaxis in Murine Peritonitis. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates the activity of DOCK guanine nucleotide exchange factors (GEFs). Acts in association with DOCK1, DOCK2 and CRK. Promotes RAC1 activation by DOCK5; the activity is stimulated by RHOG. Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility., [UniProtKB, UniProtKB]; The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BSY9;Q8K2C5;Q91ZU3", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0160124 guanyl nucleotide exchange factor activator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098794 postsynapse;GO:0032045 guanyl-nucleotide exchange factor complex", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0007015 actin filament organization;GO:0006909 phagocytosis;GO:0006915 apoptotic process;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8BPU7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CB77-1", "uniprot_id": [ { "id": "ELOA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CB77", "type": "external" } ], "mass": 87161.0, "length": 773, "protein_name": "Elongin-A", "gene_name": "Eloa", "organism": "Mouse", "refseq_name": "elongin-A", "refseq_ac": [ { "id": "NP_038764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038764", "type": "external" } ], "gene_names_uniprotkb": "Eloa; Tceb3", "gene_names_refseq": "110kDa; Eloa; Tceb3a; Tceb3", "protein_names_uniprotkb": "Elongin-A; EloA; Elongin 110 kDa subunit; RNA polymerase II transcription factor SIII subunit A1; SIII p110; Transcription elongation factor B polypeptide 3", "protein_names_refseq": "RNA polymerase II transcription factor SIII subunit A1; SIII p110; elongin 110 kDa subunit; elongin-A; transcription elongation factor B polypeptide 3", "tax_id": 10090, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:27224); (R-MMU-112382); (R-MMU-674695); (R-MMU-6796648); (R-MMU-75955)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "10575222;12604609;19144319;21183079;23806337;23828199;29153392;33334895", "class_list": "", "function": "A linkage between Elongin A function and cell cycle progression, [RefSeq, PubMed]; As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A., [UniProtKB, UniProtKB]; Elongin A associates with actively transcribed genes and modulates enhancer RNA levels with limited impact on transcription elongation rate in vivo., [RefSeq, PubMed]; Elongin A transcription elongation activity, but not its ubiquitination activity, is most important for its function in induction of transcription of ATF3 and p21., [RefSeq, PubMed]; Polycomb repressive complex 2 modulates transcription of a subset of low expression target genes in part via methylation of EloA., [RefSeq, PubMed]; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UI38;Q80VB2;Q9R0Q5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0008023 transcription elongation factor complex;GO:0016607 nuclear speck;GO:0070449 elongin complex;GO:0090734 site of DNA damage", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8CB77-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2H5-1", "uniprot_id": [ { "id": "E41L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2H5", "type": "external" } ], "mass": 98315.0, "length": 879, "protein_name": "Band 4.1-like protein 1", "gene_name": "Epb41l1", "organism": "Mouse", "refseq_name": "band 4.1-like protein 1 isoform a", "refseq_ac": [ { "id": "NP_001006665", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006665", "type": "external" } ], "gene_names_uniprotkb": "Epb41l1; Epb4.1l1; Epb4; Kiaa0338", "gene_names_refseq": "4.1N; Epb4.1l1; Epb41l1; NBL1; mKIAA0338", "protein_names_uniprotkb": "Band 4.1-like protein 1; 4.1N; Erythrocyte membrane protein band 4.1-like 1; Neuronal protein 4.1", "protein_names_refseq": "band 4.1-like protein 1 isoform a; band 4.1-like protein 1; erythrocyte protein band 4.1 like 1; neuronal protein 4.1", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); autosomal dominant intellectual developmental disorder 11 (Disease Ontology:DOID:0070041)", "pathway": " (mmu:13821); (R-MMU-399719); (R-MMU-6794361)", "pathway_count": 3, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;10414974;15345747;16452087;17114649;18034455;21183079;21750661;22517741;22645316;30059200;32448967;32782141;32848054;33046791;33300544;34428180;34678516;35820727;35822049;36852467;40021952;40885482", "class_list": "", "function": "Loss of 4.1N in epithelial ovarian cancer results in EMT and matrix-detached cell death resistance., [RefSeq, PubMed]; May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases., [UniProtKB]; Selective effects of protein 4.1N deficiency on neuroendocrine and reproductive systems. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 25, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 25, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 25, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 30, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 26, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3L1;Q3UHP7;Q80U34;Q8K204", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0005198 structural molecule activity;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0098794 postsynapse", "go_biological_process": "GO:0031032 actomyosin structure organization;GO:0030866 cortical actin cytoskeleton organization;GO:0099145 regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane", "synthesized_glycan_count": 0, "hit_score": 5.3, "record_id": "Q9Z2H5-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z101-1", "uniprot_id": [ { "id": "PAR6A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z101", "type": "external" } ], "mass": 37333.0, "length": 346, "protein_name": "Partitioning defective 6 homolog alpha", "gene_name": "Pard6a", "organism": "Mouse", "refseq_name": "partitioning defective 6 homolog alpha isoform 2", "refseq_ac": [ { "id": "NP_001040900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040900", "type": "external" } ], "gene_names_uniprotkb": "Pard6a; Par6a", "gene_names_refseq": "0710008C04Rik; 2610010A15Rik; PAR-6A; PAR6alpha; Par-6; Par6c; Par6; Pard6a; TAX40; Tip-40", "protein_names_uniprotkb": "Partitioning defective 6 homolog alpha; PAR-6 alpha; PAR-6A; PAR-6", "protein_names_refseq": "PAR-6 alpha; Tax interaction protein 40; par-6 (partitioning defective 6,) homolog alpha; partitioning defective 6 homolog alpha isoform 2; partitioning defective 6 homolog alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:56513); (R-MMU-2173791); (R-MMU-420029); (R-MMU-4608870); (R-MMU-9013149); (R-MMU-9013420); (R-MMU-9013424)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "10934475;12629547;12813044;15345747;15761148;21750661;35820727;9834192", "class_list": "", "function": "Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:15761148). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5RL03;Q6P8R2", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0031267 small GTPase binding;GO:0030742 GTP-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0060341 regulation of cellular localization;GO:0051301 cell division;GO:0001933 negative regulation of protein phosphorylation;GO:0050714 positive regulation of protein secretion;GO:1904781 positive regulation of protein localization to centrosome", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9Z101-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VM5-1", "uniprot_id": [ { "id": "RMXL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VM5", "type": "external" } ], "mass": 42162.0, "length": 388, "protein_name": "RNA binding motif protein, X-linked-like-1", "gene_name": "Rbmxl1", "organism": "Mouse", "refseq_name": "RNA binding motif protein, X-linked-like-1", "refseq_ac": [ { "id": "NP_001239018", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239018", "type": "external" } ], "gene_names_uniprotkb": "Rbmxl1; Rbmxrt", "gene_names_refseq": "Hnrpg; Rbmxl1; Rbmxrt; Rbmx", "protein_names_uniprotkb": "RNA binding motif protein, X-linked-like-1; Heterogeneous nuclear ribonucleoprotein G-like 1; RNA binding motif protein, X chromosome retrogene", "protein_names_refseq": "RNA binding motif protein, X chromosome retrogene; RNA binding motif protein, X-linked-like-1; RNA-binding motif protein, X chromosome; heterogeneous nuclear ribonucleoprotein G (hnRNP G); heterogeneous nuclear ribonucleoprotein G-like 1", "tax_id": 10090, "disease": "syndromic X-linked intellectual disability Shashi type (Disease Ontology:DOID:0060826); X-linked mental retardation Gustavson type (Disease Ontology:DOID:0081123)", "pathway": " (mmu:19656)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "22872234;31219806;33300544;34428180;37453647;9457683", "class_list": "", "function": "RNA-binding protein which may be involved in pre-mRNA splicing., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35479", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0005681 spliceosomal complex;GO:0000791 euchromatin", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0006509 membrane protein ectodomain proteolysis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051260 protein homooligomerization;GO:0048025 negative regulation of mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q91VM5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JM62-1", "uniprot_id": [ { "id": "REEP6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JM62", "type": "external" } ], "mass": 22204.0, "length": 201, "protein_name": "Receptor expression-enhancing protein 6", "gene_name": "Reep6", "organism": "Mouse", "refseq_name": "receptor expression-enhancing protein 6 isoform 2", "refseq_ac": [ { "id": "NP_001191860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191860", "type": "external" } ], "gene_names_uniprotkb": "Reep6; Dp1l1; Tb2l1", "gene_names_refseq": "0610011M24Rik; Dp1l1; Reep6", "protein_names_uniprotkb": "Receptor expression-enhancing protein 6; Polyposis locus protein 1-like 1; TB2 protein-like 1", "protein_names_refseq": "TB2 protein-like 1; deleted in polyposis 1-like 1; polyposis locus protein 1-like 1; receptor expression-enhancing protein 6 isoform 2; receptor expression-enhancing protein 6", "tax_id": 10090, "disease": "retinitis pigmentosa 77 (Disease Ontology:DOID:0080350); hereditary spastic paraplegia 31 (Disease Ontology:DOID:0110782)", "pathway": " (mmu:70335)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "15550249;15728532;21750661;22645316;24098485;24691551;28369466;28475715;32101290;34428180;35150731", "class_list": "", "function": "Knockout of mouse receptor accessory protein 6 leads to sperm function and morphology defectsdagger., [RefSeq, PubMed]; REEP6 knockout leads to defective beta-adrenergic signaling in adipocytes and promotes obesity-related metabolic dysfunction., [RefSeq, PubMed]; Required for correct function and survival of retinal photoreceptors (PubMed:24098485, PubMed:24691551, PubMed:28475715). Required for retinal development (PubMed:28369466). In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis (PubMed:28475715). May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane (PubMed:24098485, PubMed:28369466)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; TB2-like 1 is a membrane protein that belongs to the YOP1/TB2/DP1/HVA22 family, and it probably plays an important role in intracellular membrane trafficking in RGCs, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0X2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0045177 apical part of cell;GO:0005789 endoplasmic reticulum membrane;GO:0001669 acrosomal vesicle;GO:0030665 clathrin-coated vesicle membrane", "go_biological_process": "GO:0032386 regulation of intracellular transport;GO:0050908 detection of light stimulus involved in visual perception", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9JM62-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2G6-1", "uniprot_id": [ { "id": "SE1L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2G6", "type": "external" } ], "mass": 88340.0, "length": 790, "protein_name": "Protein sel-1 homolog 1", "gene_name": "Sel1l", "organism": "Mouse", "refseq_name": "protein sel-1 homolog 1 isoform a precursor", "refseq_ac": [ { "id": "NP_001034178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034178", "type": "external" } ], "gene_names_uniprotkb": "Sel1l; Sel1h", "gene_names_refseq": "Sel1h; Sel1l; mKIAA4137", "protein_names_uniprotkb": "Protein sel-1 homolog 1; Sel-1L; Suppressor of lin-12-like protein 1", "protein_names_refseq": "Sel1 (suppressor of lin-12) 1 homolog; protein sel-1 homolog 1 isoform a precursor; protein sel-1 homolog 1; sel-1L; suppressor of lin-12-like protein 1", "tax_id": 10090, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (mmu:20338); (R-MMU-382556); (R-MMU-5358346); (R-MMU-9931269)", "pathway_count": 4, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;18299400;20170518;24453213;25066055;25428506;25605945;27064360;30059200;30084848;30779550;30899004;32848054;34428180;36852467;39455574;40885482;9858735", "class_list": "", "function": "Data suggest that Sel1l is essential for the growth and differentiation of endoderm-derived pancreatic epithelial cells during mouse embryonic development. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:24453213, PubMed:25066055). Enhances SYVN1 stability (PubMed:24453213). Plays a role in LPL maturation and secretion (PubMed:25066055). Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells (PubMed:20170518, PubMed:24453213). May play a role in Notch signaling (PubMed:20170518)., [UniProtKB, PubMed, PubMed, PubMed]; Regulation of hepatic inclusions and fibrinogen biogenesis by SEL1L-HRD1 ERAD. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q9DBD8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0036513 Derlin-1 retrotranslocation complex;GO:0000836 Hrd1p ubiquitin ligase complex;GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0007219 Notch signaling pathway;GO:0009306 protein secretion;GO:0036503 ERAD pathway;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q9Z2G6-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1A4-1", "uniprot_id": [ { "id": "DOCK7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1A4", "type": "external" } ], "mass": 241438.0, "length": 2130, "protein_name": "Dedicator of cytokinesis protein 7", "gene_name": "Dock7", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dock7; Gm430; Kiaa1771; Mnlt", "gene_names_refseq": "", "protein_names_uniprotkb": "Dedicator of cytokinesis protein 7; Protein moonlight", "protein_names_refseq": "", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 23 (Disease Ontology:DOID:0080415); platelet storage pool deficiency (Disease Ontology:DOID:2223)", "pathway": " (mmu:67299); (R-MMU-8875555); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-983231)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "17242355;19129230;19131326;19144319;19202056;21183079;21750661;22645316;22842144;23806337;31219806;32782141;34428180;35820727;37828378", "class_list": "", "function": "Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (By similarity). Has a role in pigmentation (PubMed:19202056). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (PubMed:22842144)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q45V78;Q5PRE6;Q6PJ17;Q9CSB6;Q9CXM7", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0030424 axon;GO:0031594 neuromuscular junction;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0007409 axonogenesis;GO:0031175 neuron projection development;GO:0016601 Rac protein signal transduction;GO:0035023 regulation of Rho protein signal transduction;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8R1A4-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV92-1", "uniprot_id": [ { "id": "E41L3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WV92", "type": "external" } ], "mass": 103338.0, "length": 929, "protein_name": "Band 4.1-like protein 3", "gene_name": "Epb41l3", "organism": "Mouse", "refseq_name": "band 4.1-like protein 3 isoform 1", "refseq_ac": [ { "id": "NP_038841", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038841", "type": "external" } ], "gene_names_uniprotkb": "Epb41l3; Dal1; Epb4.1l3; Kiaa0987", "gene_names_refseq": "4.1B; DAL1P; Dal1; Epb4.1l3; Epb41l3; NBL3", "protein_names_uniprotkb": "Band 4.1-like protein 3; 4.1B; DAL-1; DAL1P; Differentially expressed in adenocarcinoma of the lung protein 1; Erythrocyte membrane protein band 4.1-like 3; mDAL-1", "protein_names_refseq": "DAL-1; band 4.1-like protein 3 isoform 1; band 4.1-like protein 3; differentially expressed in adenocarcinoma of the lung protein 1", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); meningioma (Disease Ontology:DOID:3565); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748)", "pathway": " (mmu:13823); (R-MMU-6794361)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "10652311;15345747;15592455;16452087;17114649;17242355;19131326;21183079;21750661;22517741;22645316;28528544;31171904;32848054;33300544;34428180;34678516;34887587;35822049;36210013;40021952;40684658;40885482", "class_list": "", "function": "Our data indicate that 4.1B is an important regulator during EMT progression in melanoma cells, which may present a potential target for the prevention and treatment of melanoma. Publication Status: Online-Only, [RefSeq, PubMed]; Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 19, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 19, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 19, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZT8;Q9R102", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0106006 cytoskeletal protein-membrane anchor activity;GO:0005198 structural molecule activity;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006915 apoptotic process;GO:0048812 neuron projection morphogenesis;GO:0031032 actomyosin structure organization;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "Q9WV92-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54916-1", "uniprot_id": [ { "id": "REPS1_MOUSE", "url": "https://www.uniprot.org/uniprot/O54916", "type": "external" } ], "mass": 86519.0, "length": 795, "protein_name": "RalBP1-associated Eps domain-containing protein 1", "gene_name": "Reps1", "organism": "Mouse", "refseq_name": "ralBP1-associated Eps domain-containing protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001104535", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104535", "type": "external" } ], "gene_names_uniprotkb": "Reps1", "gene_names_refseq": "Reps1", "protein_names_uniprotkb": "RalBP1-associated Eps domain-containing protein 1; RalBP1-interacting protein 1", "protein_names_refseq": "RalBP1 associated Eps domain containing 1; ralBP1-associated Eps domain-containing protein 1 isoform 2; ralBP1-associated Eps domain-containing protein 1; ralBP1-interacting protein 1", "tax_id": 10090, "disease": "neurodegeneration with brain iron accumulation (Disease Ontology:DOID:0110734)", "pathway": " (mmu:19707); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "11389591;17242355;19144319;21183079;21750661;22645316;25428506;30084848;31219806;32782141;32848054;32923109;34428180;35820727;35822049;40684658;40885482;9395447", "class_list": "", "function": "May coordinate the cellular actions of activated EGF receptors and Ral-GTPases., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UAM3;Q5PPQ9;Q8C9J9;Q99LR8", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0030674 protein-macromolecule adaptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit", "go_biological_process": "GO:0006897 endocytosis;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "O54916-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KGS3-1", "uniprot_id": [ { "id": "RGPA2_MOUSE", "url": "https://www.uniprot.org/uniprot/A3KGS3", "type": "external" } ], "mass": 210288.0, "length": 1872, "protein_name": "Ral GTPase-activating protein subunit alpha-2", "gene_name": "Ralgapa2", "organism": "Mouse", "refseq_name": "ral GTPase-activating protein subunit alpha-2 isoform 1", "refseq_ac": [ { "id": "NP_001028520", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028520", "type": "external" } ], "gene_names_uniprotkb": "Ralgapa2; Kiaa1272", "gene_names_refseq": "A230067G21Rik; AS250; P220; RGC2; Ralgapa2; pp250", "protein_names_uniprotkb": "Ral GTPase-activating protein subunit alpha-2; 250 kDa substrate of Akt; AS250; P220", "protein_names_refseq": "250 kDa substrate of Akt; ral GTPase-activating protein alpha subunit 2; ral GTPase-activating protein subunit alpha-2 isoform 1; ral GTPase-activating protein subunit alpha-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:241694)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;16490346;17242355;21148297;21183079;21750661;23386617;25605945;30084848;31058283;31219806;31622786;34428180", "class_list": "", "function": "Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB., [UniProtKB]; Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation., [RefSeq, PubMed]; Loss of RalGAP function has a distinct role in promoting progression from prostatic intraepithelial neoplasia to invasive adenocarcinoma., [RefSeq, PubMed]; Study reports the identification and characterization of a Ral GAP complex (RG1, RGC2) that mediates the activation of RalA downstream of the PI 3-kinase/Akt pathway, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9562, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A3KGS5;B7ZCU9;Q3TZD9;Q4VA60;Q69ZM8;Q7TQL4;Q8BYP2", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:0032880 regulation of protein localization;GO:0090630 activation of GTPase activity;GO:0060178 regulation of exocyst localization;GO:0032484 Ral protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "A3KGS3-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59598-1", "uniprot_id": [ { "id": "ASXL1_MOUSE", "url": "https://www.uniprot.org/uniprot/P59598", "type": "external" } ], "mass": 162674.0, "length": 1514, "protein_name": "Polycomb group protein ASXL1", "gene_name": "Asxl1", "organism": "Mouse", "refseq_name": "polycomb group protein ASXL1", "refseq_ac": [ { "id": "NP_001035028", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035028", "type": "external" } ], "gene_names_uniprotkb": "Asxl1; Kiaa0978", "gene_names_refseq": "Asxl1", "protein_names_uniprotkb": "Polycomb group protein ASXL1; Additional sex combs-like protein 1", "protein_names_refseq": "additional sex combs like 1; additional sex combs-like protein 1; polycomb group protein ASXL1; putative Polycomb group protein ASXL1", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); chronic myelomonocytic leukemia (Disease Ontology:DOID:0080188); myeloproliferative neoplasm (Disease Ontology:DOID:2226); SM-AHNMD (Disease Ontology:DOID:4797); myelofibrosis (Disease Ontology:DOID:4971); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:228790); (R-MMU-5689603)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "16412590;16606617;17242355;19833123;19861679;19880879;21047783;21750661;25428506;30059200;30084848;31219806;32747411;34170818;34428180;34887587;35820727", "class_list": "", "function": "ASXL1 is a novel coactivator of RAR that cooperates with SRC-1, [RefSeq, PubMed]; Asxl1 function is determined by its interacting partners or chromatin environment to bring about changes in gene regulation., [RefSeq, PubMed]; Asxl1 is needed for normal hematopoiesis., [RefSeq, PubMed]; Asxl1and Asxl2 are expressed as multiple transcripts, at varying levels, in adult tissues and in embryonic stem cells analyzed by Northern blot, and exhibit similar expression patterns suggesting they may be co-regulated, [RefSeq, PubMed]; Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) (PubMed:16606617). Acts as a coactivator of RARA and RXRA through association with NCOA1 (PubMed:16606617). Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (PubMed:21047783). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity). Acts as a sensor of N(6)-methyladenine methylation on DNA (6mA): recognizes and binds 6mA DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing (By similarity). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (By similarity). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:32747411). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (PubMed:32747411). ASXL1 and ASXL2 are important for BAP1 protein stability (By similarity). Together with BAP1, negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0042974 nuclear retinoic acid receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0035517 PR-DUB complex", "go_biological_process": "GO:0010888 negative regulation of lipid storage;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000902 cell morphogenesis;GO:0032526 response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P59598-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCZ6-1", "uniprot_id": [ { "id": "SGSM3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCZ6", "type": "external" } ], "mass": 85490.0, "length": 750, "protein_name": "Small G protein signaling modulator 3", "gene_name": "Sgsm3", "organism": "Mouse", "refseq_name": "small G protein signaling modulator 3 isoform 1", "refseq_ac": [ { "id": "NP_598852", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598852", "type": "external" } ], "gene_names_uniprotkb": "Sgsm3; Cip85; Rutbc3", "gene_names_refseq": "1810012I01Rik; Cip85; RUSC3; Rutbc3; Sgsm3", "protein_names_uniprotkb": "Small G protein signaling modulator 3; RUN and TBC1 domain-containing protein 3", "protein_names_refseq": "Cx43-interacting protein of 85-kDa; RUN and TBC1 domain-containing protein 3; small G protein signaling modulator 3 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:105835)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;15709751;17242355;17509819;21183079;21750661;32271805", "class_list": "", "function": "Functional importance of the interaction between CIP85 and connexin 43 (Cx43) is suggested by the observation that CIP85 appears to induce the turnover of Cx43 through the lysosomal pathway. (CIP85; Cx43-interacting protein of 85-kDa), [RefSeq, PubMed]; GTPase-activating protein (GAP) specific for Rab5 small GTPase for which it accelerates the intrinsic GTP hydrolysis rate, thereby controlling trafficking through the early endocytic pathway. May play a cooperative role in NF2-mediated growth suppression of cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SGSM3/Sgsm3 probably has an effect on mesenchymal stem cells (MSC) survival and thus therapeutic potential in diseased hearts, but SGSM3 may worsen the development of MSC-based therapeutic approaches in regenerative medicine. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCB6", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding;GO:0030695 GTPase regulator activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005921 gap junction", "go_biological_process": "GO:0032483 regulation of Rab protein signal transduction;GO:0032486 Rap protein signal transduction;GO:0030100 regulation of endocytosis;GO:0043547 positive regulation of GTPase activity;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8VCZ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35639-1", "uniprot_id": [ { "id": "DDIT3_MOUSE", "url": "https://www.uniprot.org/uniprot/P35639", "type": "external" } ], "mass": 19189.0, "length": 168, "protein_name": "DNA damage-inducible transcript 3 protein", "gene_name": "Ddit3", "organism": "Mouse", "refseq_name": "DNA damage-inducible transcript 3 protein", "refseq_ac": [ { "id": "NP_001277112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277112", "type": "external" } ], "gene_names_uniprotkb": "Ddit3; Chop10; Chop; Gadd153", "gene_names_refseq": "AltDDIT3; CHOP-10; CHOP10; Ddit3; chop; gadd153", "protein_names_uniprotkb": "DNA damage-inducible transcript 3 protein; C/EBP zeta; C/EBP-homologous protein 10; C/EBP-homologous protein; CCAAT/enhancer-binding protein homologous protein; CHOP-10; CHOP; DDIT-3; Growth arrest and DNA-damage-inducible protein GADD153", "protein_names_refseq": "C/EBP homoologous protein 10; C/EBP zeta; CCAAT/enhancer-binding protein homologous protein; DDIT-3; DNA damage-inducible transcript 3 protein; alternative DDIT3 proteins; c/EBP-homologous protein 10; growth arrest and DNA-damage-inducible protein GADD153", "tax_id": 10090, "disease": "brain ischemia (Disease Ontology:DOID:2316); nephrosis (Disease Ontology:DOID:2527); pulmonary tuberculosis (Disease Ontology:DOID:2957); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); borna disease (Disease Ontology:DOID:5154); ureteral obstruction (Disease Ontology:DOID:5199); myxoid liposarcoma (Disease Ontology:DOID:5363); pulmonary venoocclusive disease (Disease Ontology:DOID:5453); galactosemia (Disease Ontology:DOID:9870)", "pathway": " (mmu:13198)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "12706815;12876286;14684614;1547942;15601821;15775988;16670335;19752026;19855386;19919955;21159964;21285359;21750661;22242125;22265908;23624402;8650547", "class_list": "", "function": "Multifunctional transcription factor in endoplasmic reticulum (ER) stress response (PubMed:15601821, PubMed:19752026). Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress (PubMed:15601821, PubMed:19752026). Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes (PubMed:1547942). Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes (PubMed:1547942). Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L (PubMed:12706815, PubMed:14684614, PubMed:15775988, PubMed:19919955, PubMed:21159964). Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG) (By similarity). Together with ATF4, mediates ER-mediated cell death by promoting expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the unfolded protein response (UPR) in response to ER stress (PubMed:22242125, PubMed:23624402). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity (By similarity). Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response (PubMed:16670335). Acts as a major regulator of postnatal neovascularization through regulation of endothelial nitric oxide synthase (NOS3)-related signaling (PubMed:22265908)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Product of the upstream open reading frame (uORF) of DDIT3/CHOP that is specifically produced in absence of stress, thereby preventing translation of downstream stress effector DDIT3/CHOP., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91YW9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0036488 CHOP-C/EBP complex;GO:0005654 nucleoplasm;GO:0005770 late endosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006915 apoptotic process;GO:0016055 Wnt signaling pathway;GO:0043525 positive regulation of neuron apoptotic process;GO:0006983 ER overload response", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P35639-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2C7-1", "uniprot_id": [ { "id": "BI1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2C7", "type": "external" } ], "mass": 26478.0, "length": 237, "protein_name": "Bax inhibitor 1", "gene_name": "Tmbim6", "organism": "Mouse", "refseq_name": "bax inhibitor 1", "refseq_ac": [ { "id": "NP_001164505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164505", "type": "external" } ], "gene_names_uniprotkb": "Tmbim6; Tegt", "gene_names_refseq": "5031406P05Rik; Bi1; Tegt; Tmbim6", "protein_names_uniprotkb": "Bax inhibitor 1; BI-1; Testis-enhanced gene transcript protein; Transmembrane BAX inhibitor motif-containing protein 6", "protein_names_refseq": "BI-1; bax inhibitor 1; testis enhanced gene transcript; testis-enhanced gene transcript protein; transmembrane BAX inhibitor motif-containing protein 6", "tax_id": 10090, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); invasive ductal carcinoma (Disease Ontology:DOID:3008); cervical squamous cell carcinoma (Disease Ontology:DOID:3744)", "pathway": " (mmu:110213)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "15304216;16478805;18250455;20173027;21750661;21926971;25428506;25605945;30084848;30779550;34428180;36603706;36923943;37399733;37814860;37828378;38744890;8012111;8530040", "class_list": "", "function": "BI-1 provides endogenous protection of liver and kidney from endoplasmic reticulum stress and ischemia-reperfusion injury., [RefSeq, PubMed]; Bax Inhibitor-1 preserves pancreatic beta-cell proteostasis by limiting proinsulin misfolding and programmed cell death. Publication Status: Online-Only, [RefSeq, PubMed]; Discusses cloning of human testis enhanced gene transcript and its conservation in mouse and rat., [RefSeq, PubMed]; Discusses cloning of rat testis enhanced gene transcript and identification of its homolog in mouse., [RefSeq, PubMed]; Endoplasmic reticulum (ER)-resident protein that confers cellular protection as an anti-apoptotic protein by limiting multiple stress-inducing pathways surrounding the endoplasmic reticulum and mitochondria. Inhibits the activities of the key sensor for the endoplasmic reticulum unfolded protein response IRE1alpha/ERN1 both directly and by blocking BAX/BAK binding. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; TMBIM6 deficiency leads to bone loss by accelerating osteoclastogenesis. Erratum:[Redox Biol. 2023 Oct;66:102844. doi: 10.1016/j.redox.2023.102844. PMID: 37591763], [RefSeq, PubMed]; TMBIM6 prevents VDAC1 multimerization and improves mitochondrial quality control to reduce sepsis-related myocardial injury., [RefSeq, PubMed]; Transmembrane BAX inhibitor motif containing 6 suppresses presenilin-2 to preserve mitochondrial integrity after myocardial ischemia-reperfusion injury. Publication Status: Online-Only, [RefSeq, PubMed]; [Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TX81;Q8BFY4", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0019899 enzyme binding;GO:0031625 ubiquitin protein ligase binding;GO:0060698 endoribonuclease inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0036498 IRE1-mediated unfolded protein response;GO:0043066 negative regulation of apoptotic process;GO:0006914 autophagy;GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9D2C7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1N4-1", "uniprot_id": [ { "id": "SPAS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1N4", "type": "external" } ], "mass": 58956.0, "length": 545, "protein_name": "Spermatogenesis-associated serine-rich protein 2", "gene_name": "Spats2", "organism": "Mouse", "refseq_name": "spermatogenesis-associated serine-rich protein 2 isoform 1", "refseq_ac": [ { "id": "NP_631879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631879", "type": "external" } ], "gene_names_uniprotkb": "Spats2; Scr59", "gene_names_refseq": "2700012F11Rik; 59kDa; Scr59; Spats2; p59scr; p59", "protein_names_uniprotkb": "Spermatogenesis-associated serine-rich protein 2; Serine-rich spermatocytes and round spermatid 59 kDa protein; p59scr", "protein_names_refseq": "serine-rich spermatocytes and round spermatid 59 kDa protein; serine-rich spermatocytes and round spermatid protein, 59kDa; spermatogenesis-associated serine-rich protein 2 isoform 1; spermatogenesis-associated serine-rich protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72572)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;11944913;17242355;21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UX77;Q8C810;Q8R1P6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K1N4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E829-1", "uniprot_id": [ { "id": "AT2B1_MOUSE", "url": "https://www.uniprot.org/uniprot/G5E829", "type": "external" } ], "mass": 134747.0, "length": 1220, "protein_name": "Plasma membrane calcium-transporting ATPase 1", "gene_name": "Atp2b1", "organism": "Mouse", "refseq_name": "plasma membrane calcium-transporting ATPase 1 isoform 2", "refseq_ac": [ { "id": "NP_080758", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080758", "type": "external" } ], "gene_names_uniprotkb": "Atp2b1", "gene_names_refseq": "2810442I22Rik; Atp2b1; E130111D10Rik; Pmca1", "protein_names_uniprotkb": "Plasma membrane calcium-transporting ATPase 1; 7.2.2.10; PMCA1; Plasma membrane calcium ATPase isoform 1; Plasma membrane calcium pump isoform 1", "protein_names_refseq": "plasma membrane calcium ATPase; plasma membrane calcium pump; plasma membrane calcium-transporting ATPase 1 isoform 2; plasma membrane calcium-transporting ATPase 1", "tax_id": 10090, "disease": "Hailey-Hailey disease (Disease Ontology:DOID:0050429); autosomal dominant intellectual developmental disorder 66 (Disease Ontology:DOID:0061039); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); gestational diabetes (Disease Ontology:DOID:11714); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:67972); (R-MMU-418359); (R-MMU-5578775); (R-MMU-936837)", "pathway_count": 4, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;12209837;15178683;16956963;17242355;18630941;19131326;19144319;21183079;21750661;22311909;23266958;23460639;24805951;26392310;28827723;29950683;30862855;31219806;33300544;34203471;34428180;36210013;36674959;37828378;38507609;39927985", "class_list": "", "function": "Ca[2+] Homeostasis by Plasma Membrane Ca[2+] ATPase (PMCA) 1 Is Essential for the Development of DP Thymocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis (PubMed:16956963, PubMed:22311909, PubMed:23266958, PubMed:24805951, PubMed:26392310, PubMed:28827723, PubMed:29950683). Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction (PubMed:22311909, PubMed:24805951, PubMed:29950683). Positively regulates bone mineralization through absorption of calcium from the intestine (PubMed:23266958, PubMed:26392310). Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (PubMed:23266958). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (By similarity). May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Lack of ATP2B1 in CD4+ T Cells Causes Colitis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" }, { "id": "7.2.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.8", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005654 nucleoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:1900076 regulation of cellular response to insulin stimulus;GO:0003056 regulation of vascular associated smooth muscle contraction;GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0008217 regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "G5E829-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C050-1", "uniprot_id": [ { "id": "KS6A5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C050", "type": "external" } ], "mass": 96583.0, "length": 863, "protein_name": "Ribosomal protein S6 kinase alpha-5", "gene_name": "Rps6ka5", "organism": "Mouse", "refseq_name": "ribosomal protein S6 kinase alpha-5 isoform 2", "refseq_ac": [ { "id": "NP_001317631", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317631", "type": "external" } ], "gene_names_uniprotkb": "Rps6ka5; Msk1", "gene_names_refseq": "3110005L17Rik; 6330404E13Rik; MSK1; MSPK1; RLPK; RLSK; Rps6ka5; S6K-alpha-5", "protein_names_uniprotkb": "Ribosomal protein S6 kinase alpha-5; 2.7.11.1; 90 kDa ribosomal protein S6 kinase 5; Nuclear mitogen- and stress-activated protein kinase 1; RLSK; RSK-like protein kinase; S6K-alpha-5", "protein_names_refseq": "90 kDa ribosomal protein S6 kinase 5; RSK-like protein kinase; nuclear mitogen- and stress-activated protein kinase 1; ribosomal protein S6 kinase alpha-5 isoform 2; ribosomal protein S6 kinase alpha-5; ribosomal protein S6 kinase, polypeptide 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:73086); (R-MMU-198753); (R-MMU-199920); (R-MMU-375165); (R-MMU-5621575)", "pathway_count": 5, "publication_count": 24, "publication_id_list": "11441012;11553624;11909979;12628924;12807421;15870105;16517600;16806820;17330274;18690222;21183079;21750661;21952136;25605945;27998980;30084848;31599954;33560725;33709453;34428180;34774532;36210013;37432063;39627609", "class_list": "", "function": "Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1., [RefSeq, PubMed]; Hippocampal MSK1 regulates the behavioral and biological responses of mice to chronic social defeat stress: Involving of the BDNF-CREB signaling and neurogenesis., [RefSeq, PubMed]; MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan., [RefSeq, PubMed]; Overexpression of the MSK1 Kinase in Patients With Chronic Lung Allograft Dysfunction and Its Confirmed Role in a Murine Model., [RefSeq, PubMed]; Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (By similarity) (PubMed:11553624, PubMed:11909979, PubMed:16806820). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:16806820). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:11553624). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (By similarity). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (By similarity). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:15870105, PubMed:16517600). May also phosphorylate 'Ser-28' of histone H3 (PubMed:11441012, PubMed:15870105). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (By similarity). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (PubMed:18690222). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (PubMed:18690222). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (PubMed:12807421). Phosphorylates TRIM7 at 'Ser-106' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CI92", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0035175 histone H3S10 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0006468 protein phosphorylation;GO:0006954 inflammatory response;GO:0035556 intracellular signal transduction;GO:0043687 post-translational protein modification", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q8C050-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39053-1", "uniprot_id": [ { "id": "DYN1_MOUSE", "url": "https://www.uniprot.org/uniprot/P39053", "type": "external" } ], "mass": 97803.0, "length": 867, "protein_name": "Dynamin-1", "gene_name": "Dnm1", "organism": "Mouse", "refseq_name": "dynamin-1 isoform 2", "refseq_ac": [ { "id": "NP_001288666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288666", "type": "external" } ], "gene_names_uniprotkb": "Dnm1; Dnm; Kiaa4093", "gene_names_refseq": "Dnm1; Dnm; Ftfl; mKIAA4093", "protein_names_uniprotkb": "Dynamin-1; 3.6.5.5; Dynamin I; Dynamin", "protein_names_refseq": "dynamin I; dynamin-1 isoform 2", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 31B (Disease Ontology:DOID:0070376); developmental and epileptic encephalopathy 31A (Disease Ontology:DOID:0080437); Alzheimer's disease (Disease Ontology:DOID:10652); generalized epilepsy (Disease Ontology:DOID:1827); collagen disease (Disease Ontology:DOID:854)", "pathway": " (mmu:13429); (R-MMU-166016); (R-MMU-190873); (R-MMU-196025); (R-MMU-2132295); (R-MMU-437239); (R-MMU-8856828)", "pathway_count": 7, "publication_count": 28, "publication_id_list": "10.1101/2023.09.13.557529;11042120;11082044;11956154;12456676;15592455;16800626;17463283;18034455;19781630;20700442;21183079;21750661;24129315;24224061;28135057;30084848;30779550;31219806;31599954;32848054;33300544;34428180;35220002;38641407;38744819;40684658;9143510", "class_list": "", "function": "Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission and participates in many forms of endocytosis, such as clathrin-mediated endocytosis or synaptic vesicle endocytosis as well as rapid endocytosis (RE). Associates to the membrane, through lipid binding, and self-assembles into rings and stacks of interconnected rings through oligomerization to form a helical polymer around the vesicle membrane leading to constriction of invaginated coated pits around their necks. Self-assembly of the helical polymer induces membrane tubules narrowing until the polymer reaches a length sufficient to trigger GTP hydrolysis. Depending on the curvature imposed on the tubules, membrane detachment from the helical polymer upon GTP hydrolysis can cause spontaneous hemifission followed by complete fission. May play a role in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells through its activation by dephosphorylation via the signaling downstream of EGFR (By similarity). Controls vesicle size at a step before fission, during formation of membrane pits, at hippocampal synapses (PubMed:35220002). Controls plastic adaptation of the synaptic vesicle recycling machinery to high levels of activity (PubMed:35220002). Mediates rapid endocytosis (RE), a Ca(2+)-dependent and clathrin- and K(+)-independent process in chromaffin cells. Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP (By similarity). Through its interaction with DNAJC6, acts during the early steps of clathrin-coated vesicle (CCV) formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Dynamin1 long- and short-tail isoforms exploit distinct recruitment and spatial patterns to form endocytic nanoclusters. Publication Status: Online-Only, [RefSeq, PubMed]; Missense mutation in conserved alternate exon of dynamin-1 causes epilepsy in a mouse model. Publication Status: Online-Only, [RefSeq, PubMed]; The Structural and Functional Integrity of Rod Photoreceptor Ribbon Synapses Depends on Redundant Actions of Dynamins 1 and 3. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein is a GTPase which is required for membrane recycling, including vesicle endocytosis in neurons. It may also be involved in cellular fission via association with microtubules and actin filaments. Mutations in this gene have been shown to cause seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 5, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A2AN50;A2AN51;A2AN54;A2AN55;Q3UNM1;Q5DTN7;Q61358;Q61359;Q61360;Q6PDM5;Q8JZZ4;Q9CSY7;Q9QXX1", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098835 presynaptic endocytic zone membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005874 microtubule", "go_biological_process": "GO:1900244 positive regulation of synaptic vesicle endocytosis;GO:0006897 endocytosis;GO:0031623 receptor internalization;GO:0051260 protein homooligomerization;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "P39053-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BVA5-1", "uniprot_id": [ { "id": "LDAH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BVA5", "type": "external" } ], "mass": 37374.0, "length": 326, "protein_name": "Lipid droplet-associated hydrolase", "gene_name": "Ldah", "organism": "Mouse", "refseq_name": "lipid droplet-associated hydrolase isoform 2", "refseq_ac": [ { "id": "NP_001161239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161239", "type": "external" } ], "gene_names_uniprotkb": "Ldah", "gene_names_refseq": "1110057K04Rik; Ldah; mLDAH", "protein_names_uniprotkb": "Lipid droplet-associated hydrolase; 3.1.1.13; Lipid droplet-associated serine hydrolase; mLDAH", "protein_names_refseq": "LD-associated hydrolase; UPF0554 protein C2orf43 homolog; lipid droplet-associated hydrolase isoform 2; lipid droplet-associated serine hydrolase", "tax_id": 10090, "disease": "", "pathway": " (mmu:68832)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;23525007;24357060;27836991;28578400;30169630;31219806;34428180", "class_list": "", "function": "Associates with lipid droplets but does not stimulate cellular triglyceride accumulation, lipid droplet fusion or ATGL proteasomal degradation., [UniProtKB, PubMed]; Our data suggest that LDAH is not a major cholesterol ester hydrolase, and an alternative metabolic function may be responsible for its possible effect on development of prostate cancer., [RefSeq, PubMed]; Probable serine lipid hydrolase associated with lipid droplets (PubMed:24357060, PubMed:28578400). Has low cholesterol esterase activity (PubMed:24357060, PubMed:27836991). Appears to lack triglyceride lipase activity (PubMed:23525007, PubMed:24357060, PubMed:27836991). Involved in cholesterol and triglyceride homeostasis; stimulates cellular triglyceride accumulation and cellular cholesterol release (PubMed:24357060, PubMed:28578400). Acts antagonistically with PNPLA2/ATGL in regulation of cellular lipid stores (PubMed:28578400). May regulate triglyceride accumulation indirectly through stimulation of PNPLA2/ATGL ubiquitination and proteasomal degradation (PubMed:28578400). Promotes microtubule-dependent lipid droplet fusion (PubMed:28578400). Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages (PubMed:24357060)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Probable serine lipid hydrolase associated with lipid droplets. Has low cholesterol esterase activity. Appears to lack triglyceride lipase activity. Involved in cholesterol and triglyceride homeostasis; stimulates cellular triglyceride accumulation and cellular cholesterol release. Acts antagonistically with PNPLA2/ATGL in regulation of cellular lipid stores. May regulate triglyceride accumulation indirectly through stimulation of PNPLA2/ATGL ubiquitination and proteasomal degradation. Promotes microtubule-dependent lipid droplet fusion. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages., [UniProtKB, UniProtKB, UniProtKB]; Stimulates cellular triglyceride accumulation and lipid droplet fusion., [UniProtKB, PubMed]; The data identify LDAH a candidate target to promote reverse cholesterol transport from atherosclerotic lesions., [RefSeq, PubMed]; This study identified a novel lipid droplets -associated protein family, represented by the Drosophila protein CG9186 and its murine homolog MGI:1916082., [RefSeq, PubMed]; We then amassed convergent genomic evidence showing population level associations between LDAHexpression and occurrence of prostate cancer . We further identified loss of LDAH in both tissues and cell lines derived from human prostate cancer, and generated Ldah-/- mouse model, which recapitulated many of the clinical findings in DGAP056. Erratum:[Hum Mol Genet. 2019 May 15;28(10):1753-1754. doi: 10.1093/hmg/ddz036. PMID: 31222336], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0F6AIX5;A0A1W2P7C8;Q3TRE7;Q5RL52;Q6PG15;Q8BVV0", "ec_number_list": [ { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.71", "type": "external" }, { "id": "3.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.1", "type": "external" } ], "go_molecular_function": "GO:0004771 sterol ester esterase activity;GO:0016298 lipase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet", "go_biological_process": "GO:0042632 cholesterol homeostasis;GO:0019915 lipid storage;GO:0034389 lipid droplet organization;GO:0035356 intracellular triglyceride homeostasis;GO:0090077 foam cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BVA5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NZL0-1", "uniprot_id": [ { "id": "MTCL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NZL0", "type": "external" } ], "mass": 103480.0, "length": 945, "protein_name": "Microtubule cross-linking factor 3", "gene_name": "Mtcl3", "organism": "Mouse", "refseq_name": "microtubule cross-linking factor 3 precursor", "refseq_ac": [ { "id": "NP_080414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080414", "type": "external" } ], "gene_names_uniprotkb": "Mtcl3; Soga3", "gene_names_refseq": "6330407J23Rik; Mtcl3; Soga3", "protein_names_uniprotkb": "Microtubule cross-linking factor 3", "protein_names_refseq": "SOGA family member 3; microtubule cross-linking factor 3 precursor; microtubule cross-linking factor 3; protein SOGA3", "tax_id": 10090, "disease": "", "pathway": " (mmu:67412)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLM2;Q9CSN3;Q9CU45", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0010506 regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6NZL0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99NF3-1", "uniprot_id": [ { "id": "CEP41_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99NF3", "type": "external" } ], "mass": 41442.0, "length": 373, "protein_name": "Centrosomal protein of 41 kDa", "gene_name": "Cep41", "organism": "Mouse", "refseq_name": "centrosomal protein of 41 kDa", "refseq_ac": [ { "id": "NP_114387", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114387", "type": "external" } ], "gene_names_uniprotkb": "Cep41; Tsga14", "gene_names_refseq": "1700017E11Rik; 2810431D15Rik; Cep41; Tsga14", "protein_names_uniprotkb": "Centrosomal protein of 41 kDa; Cep41; Testis-specific gene A14 protein", "protein_names_refseq": "centrosomal protein of 41 kDa; testis specific gene A14", "tax_id": 10090, "disease": "Joubert syndrome 15 (Disease Ontology:DOID:0110984)", "pathway": " (mmu:83922); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 10, "publication_id_list": "15345747;21183079;21750661;21952136;22246503;24129315;25428506;25605945;30084848;34428180", "class_list": "", "function": "Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium., [UniProtKB, PubMed]; This gene encodes a centrosomal protein which may be required for tubulin glutamylation in cilia during ciliogenesis. Mutations in a similar gene in human have been associated with Joubert Syndrome 15, an autosomal recessive ciliopathy and neurological disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3Z3U1;F7CSA6;Q3TTB5;Q8BT53", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0015031 protein transport;GO:0060271 cilium assembly;GO:0018095 protein polyglutamylation;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99NF3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R418-1", "uniprot_id": [ { "id": "DICER_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R418", "type": "external" } ], "mass": 216821.0, "length": 1916, "protein_name": "Endoribonuclease Dicer", "gene_name": "Dicer1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dicer1; Dicer; Mdcr", "gene_names_refseq": "", "protein_names_uniprotkb": "Endoribonuclease Dicer; 3.1.26.3; Double-strand-specific ribonuclease mDCR-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "multinodular goiter (Disease Ontology:DOID:0050489); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); nephroma (Disease Ontology:DOID:0080615); DICER1 syndrome (Disease Ontology:DOID:0081063); stomach cancer (Disease Ontology:DOID:10534); DiGeorge syndrome (Disease Ontology:DOID:11198); dilated cardiomyopathy (Disease Ontology:DOID:12930); middle cerebral artery infarction (Disease Ontology:DOID:3525); pleuropulmonary blastoma (Disease Ontology:DOID:4769); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-MMU-203927); (R-MMU-426486)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11889553;12526743;15081373;18268334;21183079;21750661;24209619;25428506;25605945;30084848;31616917;34428180", "class_list": "", "function": "Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; More active than isoform 1 to process long double-stranded RNA into siRNAs. Responsible for the accumulation of endogenous siRNAs observed in mouse oocytes compared to somatic cells and it regulates meiotic spindle organization in female germline., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 11, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8R419", "ec_number_list": [ { "id": "3.1.26.n2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.n2", "type": "external" }, { "id": "3.1.26.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.3", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon", "go_biological_process": "GO:0051252 regulation of RNA metabolic process;GO:0031508 pericentric heterochromatin formation;GO:0070173 regulation of enamel mineralization;GO:0070922 RISC complex assembly;GO:1905564 positive regulation of vascular endothelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8R418-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62108-1", "uniprot_id": [ { "id": "DLG4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62108", "type": "external" } ], "mass": 80472.0, "length": 724, "protein_name": "Disks large homolog 4", "gene_name": "Dlg4", "organism": "Mouse", "refseq_name": "disks large homolog 4 isoform 2", "refseq_ac": [ { "id": "NP_001103222", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103222", "type": "external" } ], "gene_names_uniprotkb": "Dlg4; Dlgh4; Psd95", "gene_names_refseq": "Dlg4; Dlgh4; PSD-95; PSD95; SAP90A; SAP90", "protein_names_uniprotkb": "Disks large homolog 4; PSD-95; Postsynaptic density protein 95; SAP-90; SAP90; Synapse-associated protein 90", "protein_names_refseq": "PSD-95 alpha 2b; PSD-95 beta; SAP-90; discs large homolog 4; discs, large homolog 4; disks large homolog 4 isoform 2; disks large homolog 4; postsynaptic density protein 95; synapse-associated protein 90", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); autism spectrum disorder (Disease Ontology:DOID:0060041); benign neoplasm (Disease Ontology:DOID:0060072); chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); autosomal dominant intellectual developmental disorder 62 (Disease Ontology:DOID:0061035); Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); cancer (Disease Ontology:DOID:162); Williams-Beuren syndrome (Disease Ontology:DOID:1928); carcinoma (Disease Ontology:DOID:305); temporal lobe epilepsy (Disease Ontology:DOID:3328); kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:13385); (R-MMU-399719); (R-MMU-438066); (R-MMU-451308); (R-MMU-5625900); (R-MMU-5673001); (R-MMU-5682910); (R-MMU-6794361); (R-MMU-8849932)", "pathway_count": 9, "publication_count": 33, "publication_id_list": "10.1101/2023.09.13.557529;11134026;11483650;11997254;14988405;15358775;16452087;16828986;16980967;18034455;19243221;19474308;20089912;20178993;21183079;21750661;24069373;24153177;25869807;25979765;26931375;27687706;28334377;29199957;31219806;31651360;33300544;33981040;37261953;38233523;38452102;40684658;9853749", "class_list": "", "function": "Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins (PubMed:15358775, PubMed:9853749). Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (Probable). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5NCV5;Q5NCV6;Q5NCV7;Q91WJ1", "ec_number_list": [], "go_molecular_function": "GO:0031698 beta-2 adrenergic receptor binding;GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0019901 protein kinase binding;GO:0033130 acetylcholine receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0098989 NMDA selective glutamate receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007399 nervous system development;GO:0007626 locomotory behavior;GO:0048169 regulation of long-term neuronal synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q62108-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09039-1", "uniprot_id": [ { "id": "SH2B3_MOUSE", "url": "https://www.uniprot.org/uniprot/O09039", "type": "external" } ], "mass": 60487.0, "length": 548, "protein_name": "SH2B adapter protein 3", "gene_name": "Sh2b3", "organism": "Mouse", "refseq_name": "SH2B adapter protein 3 isoform 1", "refseq_ac": [ { "id": "NP_001293055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001293055", "type": "external" } ], "gene_names_uniprotkb": "Sh2b3; Lnk", "gene_names_refseq": "Lnk; Sh2b3", "protein_names_uniprotkb": "SH2B adapter protein 3; Lymphocyte adapter protein; Lymphocyte-specific adapter protein Lnk; Signal transduction protein Lnk", "protein_names_refseq": "SH2B adapter protein 3 isoform 1; SH2B adapter protein 3; linker of T-cell receptor pathways; lymphocyte-specific adapter protein Lnk; signal transduction protein Lnk", "tax_id": 10090, "disease": "chromosome 16p11.2 deletion syndrome, 220-kb (Disease Ontology:DOID:0060398); familial erythrocytosis 1 (Disease Ontology:DOID:0060652); colorectal carcinoma (Disease Ontology:DOID:0080199); hypertension (Disease Ontology:DOID:10763); essential thrombocythemia (Disease Ontology:DOID:2224); myelofibrosis (Disease Ontology:DOID:4971); chronic myeloid leukemia (Disease Ontology:DOID:8552); colorectal cancer (Disease Ontology:DOID:9256); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:16923); (R-MMU-1433559); (R-MMU-9706369); (R-MMU-983231)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "11114373;11805142;12517931;21183079;21750661;26740625;30084848;34464969;34740959;34846914;35820727;38096361", "class_list": "", "function": "Hematopoietic and eosinophil-specific LNK(SH2B3) deficiency promotes eosinophilia and arterial thrombosis., [RefSeq, PubMed]; Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase., [UniProtKB, UniProtKB, UniProtKB]; Lnk overexpression in transgenic mice results in impaired expansion of lymphoid precursor cells and altered mature B cell subpopulations., [RefSeq, PubMed]; Lnk plays critical roles in the expansion and function of early hematopoietic progenitors Erratum:[J Exp Med 2002 May 6;195(9):1229], [RefSeq, PubMed]; Nf1 and Sh2b3 mutations cooperate in vivo in a mouse model of juvenile myelomonocytic leukemia., [RefSeq, PubMed]; Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency. Erratum:[Circulation. 2022 Jul 26;146(4):e13. doi: 10.1161/CIR.0000000000001087. PMID: 35877838], [RefSeq, PubMed]; The Autoimmune Risk R262W Variant of the Adaptor SH2B3 Improves Survival in Sepsis., [RefSeq, PubMed]; This gene encodes a member of the SH2B family of adapter proteins that play an important role in T cell receptor signaling. This gene is preferentially expressed in hematopoietic stem cells, hematopoietic progenitors, pre and immature B cells, as well as megakaryocytes and mastocytes. In hematopoietic stem cells, the encoded protein is a key regulator of self-renewal, proliferation and apoptosis. Mice lacking the encoded protein exhibit pre and immature B cell expansion in spleen and the bone marrow. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0005173 stem cell factor receptor binding;GO:0044877 protein-containing complex binding;GO:0030159 signaling receptor complex adaptor activity;GO:1990782 protein tyrosine kinase binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1990869 cellular response to chemokine;GO:0035162 embryonic hemopoiesis;GO:0070100 negative regulation of chemokine-mediated signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O09039-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40645-1", "uniprot_id": [ { "id": "SOX6_MOUSE", "url": "https://www.uniprot.org/uniprot/P40645", "type": "external" } ], "mass": 91803.0, "length": 827, "protein_name": "Transcription factor SOX-6", "gene_name": "Sox6", "organism": "Mouse", "refseq_name": "transcription factor SOX-6 isoform 1", "refseq_ac": [ { "id": "NP_001264255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264255", "type": "external" } ], "gene_names_uniprotkb": "Sox6; Sox-6", "gene_names_refseq": "SOX-LZ; Sox6", "protein_names_uniprotkb": "Transcription factor SOX-6; SOX-LZ", "protein_names_refseq": "SRY-box containing gene 6; transcription factor SOX-6 isoform 1; transcription factor SOX-6", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); heart disease (Disease Ontology:DOID:114); high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (mmu:20679); (R-MMU-3769402)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10996314;11702786;12414734;14530442;14993235;15529345;1614875;17242355;17433257;21183079;21750661;24662752;26150426;26525805;27923061;32442410;33109704;34203471;7567444;7791783;9755172", "class_list": "", "function": "This gene encodes a member of a family of transcriptional regulators containing high mobility group (HMG) DNA-binding domains. Function of the encoded protein is important for proper cardiac and skeletal development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]., [RefSeq]; Thus, we successfully identified the Sox6 promoter and its core enhancer and characterized the interactions with regulatory transcription factors., [RefSeq, PubMed]; Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis (PubMed:11702786, PubMed:9755172). Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate (PubMed:11702786, PubMed:15529345, PubMed:26150426). Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes (PubMed:14993235, PubMed:26150426). Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts (PubMed:14993235). Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube (PubMed:26525805). Binds to the gene promoter of MBP and acts as a transcriptional repressor (PubMed:26525805)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62250;Q9QWS5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0048708 astrocyte differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P40645-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0M6-1", "uniprot_id": [ { "id": "RAB9A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0M6", "type": "external" } ], "mass": 22910.0, "length": 201, "protein_name": "Ras-related protein Rab-9A", "gene_name": "Rab9a; Rab9", "organism": "Mouse", "refseq_name": "ras-related protein Rab-9A", "refseq_ac": [ { "id": "NP_062747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062747", "type": "external" } ], "gene_names_uniprotkb": "Rab9a; Rab9; Rab9; Sid99", "gene_names_refseq": "2410064E05Rik; Rab9a; Rab9; Sid6061p", "protein_names_uniprotkb": "Ras-related protein Rab-9A; 3.6.5.2; Sid 99", "protein_names_refseq": "SID 99; rab-9A; ras-related protein Rab-9A", "tax_id": 10090, "disease": "", "pathway": " (mmu:56382); (R-MMU-6811440); (R-MMU-8873719); (R-MMU-8876198); (R-MMU-9706019)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "16075062;20048159;21183079;21750661;25220469;26495903;26620560;30511961;34428180;34610499;35018428;38373380", "class_list": "", "function": "IL-4 activates ULK1/Atg9a/Rab9 in asthma, NLRP3 inflammasomes, and Golgi fragmentation by increasing autophagy flux and mitochondrial oxidative stress., [RefSeq, PubMed]; Mitophagy mediated through the Ulk1/Rab9/Rip1/Drp1 pathway protected the heart against ischemia by maintaining healthy mitochondria., [RefSeq, PubMed]; Rab9 Mediates Pancreatic Autophagy Switch From Canonical to Noncanonical, Aggravating Experimental Pancreatitis., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB9A is involved in the transport of proteins between the endosomes and the trans-Golgi network (TGN). Specifically uses NDE1/NDEL1 as an effector to interact with the dynein motor complex in order to control retrograde trafficking of RAB9-associated late endosomes to the TGN (By similarity). Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (PubMed:26620560)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport;GO:0032880 regulation of protein localization;GO:0006898 receptor-mediated endocytosis;GO:0042147 retrograde transport, endosome to Golgi;GO:0032482 Rab protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9R0M6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QWI6-1", "uniprot_id": [ { "id": "SRCN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QWI6", "type": "external" } ], "mass": 134859.0, "length": 1250, "protein_name": "SRC kinase signaling inhibitor 1", "gene_name": "Srcin1", "organism": "Mouse", "refseq_name": "SRC kinase signaling inhibitor 1", "refseq_ac": [ { "id": "NP_061361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061361", "type": "external" } ], "gene_names_uniprotkb": "Srcin1; Kiaa1684; P140", "gene_names_refseq": "P140; SNIP; Srcin1; mKIAA1684; p140Cap", "protein_names_uniprotkb": "SRC kinase signaling inhibitor 1; SNAP-25-interacting protein; SNIP; p130Cas-associated protein; p140Cap", "protein_names_refseq": "SRC kinase signaling inhibitor 1; Snap-25-interacting protein; p130Cas-associated protein", "tax_id": 10090, "disease": "cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:56013)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14657239;15345747;16452087;17114649;18034455;19146815;21183079;21750661;22517741;22645316;24129315;32848054;34418053;34678516;37704928;38878321;40885482", "class_list": "", "function": "Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance (By similarity)., [UniProtKB]; Circ-USP9X accelerates deep vein thrombosis after fracture by acting as a miR-148b-3p sponge and upregulates SRC kinase signaling inhibitor 1. Publication Status: Online-Only, [RefSeq, PubMed]; SNX17 Mediates Dendritic Spine Maturation via p140Cap., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 14, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 14, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 14, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 37, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "O70298", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium", "go_biological_process": "GO:0050709 negative regulation of protein secretion;GO:0007162 negative regulation of cell adhesion;GO:0061098 positive regulation of protein tyrosine kinase activity;GO:0034446 substrate adhesion-dependent cell spreading;GO:0061099 negative regulation of protein tyrosine kinase activity", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q9QWI6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4VBE4-1", "uniprot_id": [ { "id": "EGFLA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4VBE4", "type": "external" } ], "mass": 110735.0, "length": 1017, "protein_name": "Pikachurin", "gene_name": "Egflam", "organism": "Mouse", "refseq_name": "pikachurin isoform 1 precursor", "refseq_ac": [ { "id": "NP_001276425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276425", "type": "external" } ], "gene_names_uniprotkb": "Egflam", "gene_names_refseq": "5930412K08; Egflam", "protein_names_uniprotkb": "Pikachurin; EGF-like, fibronectin type-III and laminin G-like domain-containing protein; Nectican", "protein_names_refseq": "EGF-like, fibronectin type-III and laminin G-like domain-containing protein; nectican; pikachurin isoform 1 precursor; pikachurin", "tax_id": 10090, "disease": "", "pathway": " (mmu:268780)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18641643;18757743;20682766;21129441;21750661;26091521;30282023;34428180", "class_list": "", "function": "Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception (PubMed:18641643, PubMed:18757743, PubMed:30282023). Plays a key role in the synaptic organization of photoreceptors by mediating transsynaptic interaction between alpha-dystroglycan and GPR179 on the postsynaptic membrane (PubMed:30282023). Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse (PubMed:18641643, PubMed:18757743, PubMed:30282023). Promotes matrix assembly and cell adhesiveness (PubMed:18641643, PubMed:18757743)., [UniProtKB, PubMed, PubMed, PubMed]; Pikachurin Protein Required for Increase of Cone Electroretinogram B-Wave during Light Adaptation Publication Status: Online-Only, [RefSeq, PubMed]; Post-translational maturation of dystroglycan is necessary for pikachurin binding and ribbon synaptic localization., [RefSeq, PubMed]; These results indicate that pikachurin interactions with alpha-dystroglycan and its localization at the photoreceptor ribbon synapse require normal glycosylation of alpha-dystroglycan., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RWU6;B6JU28;Q80WX4;Q8BGP3", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005509 calcium ion binding;GO:0005539 glycosaminoglycan binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0045202 synapse;GO:0048786 presynaptic active zone;GO:0043083 synaptic cleft", "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0030198 extracellular matrix organization;GO:0007416 synapse assembly;GO:0010811 positive regulation of cell-substrate adhesion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q4VBE4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P1E8-1", "uniprot_id": [ { "id": "EFCB6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P1E8", "type": "external" } ], "mass": 175771.0, "length": 1516, "protein_name": "EF-hand calcium-binding domain-containing protein 6", "gene_name": "Efcab6", "organism": "Mouse", "refseq_name": "EF-hand calcium-binding domain-containing protein 6 isoform 2", "refseq_ac": [ { "id": "NP_001155100", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155100", "type": "external" } ], "gene_names_uniprotkb": "Efcab6; Djbp; Kiaa1672", "gene_names_refseq": "4931407K02Rik; 4932408N08Rik; Efcab6; bM150J22.2; mKIAA1672", "protein_names_uniprotkb": "EF-hand calcium-binding domain-containing protein 6; DJ-1-binding protein; DJBP", "protein_names_refseq": "DJ-1-binding protein; DJBP; EF-hand calcium-binding domain-containing protein 6 isoform 2; EF-hand calcium-binding domain-containing protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:77627)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21750661;34203471;37295417;37865089;37989994", "class_list": "", "function": "Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex (By similarity). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:37295417, PubMed:37865089, PubMed:37989994)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6PW10;A6PW11;A6PW12;Q5DTV8;Q6PGK8;Q9D2D8", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0036126 sperm flagellum;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6P1E8-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1B4-1", "uniprot_id": [ { "id": "EIF3C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1B4", "type": "external" } ], "mass": 105531.0, "length": 911, "protein_name": "Eukaryotic translation initiation factor 3 subunit C", "gene_name": "Eif3c", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 3 subunit C", "refseq_ac": [ { "id": "NP_666312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666312", "type": "external" } ], "gene_names_uniprotkb": "Eif3c; Eif3s8", "gene_names_refseq": "110kDa; 3230401O13Rik; Eif3c; Eif3s8; NIPIL(A3); NipilA3; Xsl; Xs", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit C; Eukaryotic translation initiation factor 3 subunit 8; eIF3 p110; eIF3c", "protein_names_refseq": "NIPI-like protein; eIF3 p110; eukaryotic translation initiation factor 3 subunit 8; eukaryotic translation initiation factor 3 subunit C; eukaryotic translation initiation factor 3, subunit 8 (110 kDa); extra-toes spotting", "tax_id": 10090, "disease": "", "pathway": " (mmu:56347); (R-MMU-156827); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706)", "pathway_count": 7, "publication_count": 20, "publication_id_list": "17114649;17581632;17622165;19131326;21183079;21750661;22872234;23386199;23806337;25605945;30084848;31219806;33300544;34428180;34887587;36157221;36210013;37453647;37507081;39627609", "class_list": "", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression., [UniProtKB, PubMed, HAMAP]; EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the APP/HSPA1A/LMNB1 Axis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3M7", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0043022 ribosome binding;GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q8R1B4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BL99-1", "uniprot_id": [ { "id": "DOP1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BL99", "type": "external" } ], "mass": 269257.0, "length": 2399, "protein_name": "Protein DOP1A", "gene_name": "Dop1a", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dop1a; D9Ertd809e; Dopey1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein DOP1A", "protein_names_refseq": "", "tax_id": 10090, "disease": "Down syndrome (Disease Ontology:DOID:14250)", "pathway": "", "pathway_count": 0, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;25428506;31219806;34203471;34428180;36210013;39927985", "class_list": "", "function": "May be involved in protein traffic between late Golgi and early endosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80XM5;Q8BIX5;Q8BIY4;Q8BLK8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005798 Golgi-associated vesicle;GO:0005829 cytosol", "go_biological_process": "GO:0015031 protein transport;GO:0006895 Golgi to endosome transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BL99-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XM9-1", "uniprot_id": [ { "id": "DLG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91XM9", "type": "external" } ], "mass": 94880.0, "length": 852, "protein_name": "Disks large homolog 2", "gene_name": "Dlg2", "organism": "Mouse", "refseq_name": "disks large homolog 2 isoform 3", "refseq_ac": [ { "id": "NP_001229976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229976", "type": "external" } ], "gene_names_uniprotkb": "Dlg2; Dlgh2", "gene_names_refseq": "A330103J02Rik; B230218P12Rik; B330007M19Rik; Dlg2; Dlgh2; Gm1197; Gm21505; PSD93", "protein_names_uniprotkb": "Disks large homolog 2; Channel-associated protein of synapse-110; Chapsyn-110; Postsynaptic density protein PSD-93", "protein_names_refseq": "channel-associated protein of synapse-110; chapsyn-110; discs large MAGUK scaffold protein 2 eta; discs large MAGUK scaffold protein 2 gamma; discs, large homolog 2; disks large homolog 2 isoform 3; disks large homolog 2; postsynaptic density protein PSD-93", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); benign neoplasm (Disease Ontology:DOID:0060072); chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:23859); (R-MMU-438066); (R-MMU-5673001); (R-MMU-6794361)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;11997254;12890763;14724236;15304517;16452087;18034455;19243221;20054121;20089912;21183079;21750661;22645316;29703139;31219806;33300544;34428180;36210013;40885482", "class_list": "", "function": "Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0A2L2P595;F8VQM7;Q8BXK7;Q8BYG5", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019900 kinase binding;GO:0044877 protein-containing complex binding;GO:0030165 PDZ domain binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0099641 anterograde axonal protein transport;GO:0007399 nervous system development;GO:0007268 chemical synaptic transmission;GO:0019233 sensory perception of pain;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q91XM9-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A5Z6-1", "uniprot_id": [ { "id": "SMUF2_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A5Z6", "type": "external" } ], "mass": 86175.0, "length": 748, "protein_name": "E3 ubiquitin-protein ligase SMURF2", "gene_name": "Smurf2", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase SMURF2 isoform 1", "refseq_ac": [ { "id": "NP_079757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079757", "type": "external" } ], "gene_names_uniprotkb": "Smurf2", "gene_names_refseq": "2810411E22Rik; Smurf2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase SMURF2; 2.3.2.26; HECT-type E3 ubiquitin transferase SMURF2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2", "protein_names_refseq": "E3 ubiquitin-protein ligase SMURF2 isoform 1; E3 ubiquitin-protein ligase SMURF2; HECT-type E3 ubiquitin transferase SMURF2; SMAD ubiquitination regulatory factor 2", "tax_id": 10090, "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745)", "pathway": " (mmu:66313); (R-MMU-201451); (R-MMU-2173788); (R-MMU-2173795); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-5632684); (R-MMU-5689880); (R-MMU-8941858); (R-MMU-983168)", "pathway_count": 10, "publication_count": 12, "publication_id_list": "15820682;16373342;18448069;21750661;24925320;33097595;34428180;35304894;35538534;36063900;37800598;37828378", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:24925320). Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby down-regulating TGF-beta signaling (By similarity). In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1 (By similarity). Also forms a stable complex with TGF-beta receptor-mediated phosphorylated SMAD1, SMAD2 and SMAD3, and targets SMAD1 and SMAD2 for ubiquitination and proteasome-mediated degradation (By similarity). SMAD2 may recruit substrates, such as SNON, for ubiquitin-dependent degradation (By similarity). Negatively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation (By similarity). Acts as an activator of ferroptosis by mediating ubiquitination and degradation of GSTP1, thereby preventing detoxification of 4-hydroxynonenal (4-HNE) reactive aldehyde (By similarity). Acts as a positive regulator of smoothened signaling pathway by mediating ubiquitination of PTCH1, leading to endocytosis and lysosomal degradation of PTCH1 (PubMed:24925320)., [UniProtKB, UniProtKB, PubMed]; Flavin containing monooxygenase 2 regulates renal tubular cell fibrosis and paracrine secretion via SMURF2 in AKI-CKD transformation., [RefSeq, PubMed]; Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells. Publication Status: Online-Only, [RefSeq, PubMed]; Smurf2 Regulates Inflammation and Collagen Processing in Cutaneous Wound Healing through Transforming Growth Factor-beta/Smad3 Signaling., [RefSeq, PubMed]; Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A5Z7;Q5IRE6", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0005160 transforming growth factor beta receptor binding;GO:0046332 SMAD binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0045121 membrane raft", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030514 negative regulation of BMP signaling pathway;GO:0016567 protein ubiquitination;GO:1901165 positive regulation of trophoblast cell migration;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "A2A5Z6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYI3-1", "uniprot_id": [ { "id": "DNJC7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYI3", "type": "external" } ], "mass": 56476.0, "length": 494, "protein_name": "DnaJ homolog subfamily C member 7", "gene_name": "Dnajc7", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily C member 7 isoform 1", "refseq_ac": [ { "id": "NP_062769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062769", "type": "external" } ], "gene_names_uniprotkb": "Dnajc7; Ttc2", "gene_names_refseq": "2010003F24Rik; 2010004G07Rik; CCRP; Dnajc7; Ttc2; mDj11; mTpr2", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 7; CCRP; Cytoplasmic CAR retention protein; MDj11; TPR repeat protein 2; Tetratricopeptide repeat protein 2", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 7; TPR repeat protein 2; cytoplasmic CAR retention protein; dnaJ homolog subfamily C member 7 isoform 1; dnaJ homolog subfamily C member 7; tetratricopeptide repeat domain 2; tetratricopeptide repeat protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:56354)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11147971;14573755;21750661;24788674;25428506;25542016;26740625;28135057;28528544;30010631;34504072", "class_list": "", "function": "Acts as a co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes (By similarity). Recruits NR1I3 to the cytoplasm., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation. Publication Status: Online-Only, [RefSeq, PubMed]; In CCRP knockout (KO) mice CCRP regulates CAR at multiple steps in activation of the cytochrome 2b10 gene in liver: nuclear accumulation, RNA polymerase II recruitment and epigenetic modifications. Publication Status: Online-Only, [RefSeq, PubMed]; Present study characterized a novel physiological role of CCRP in protecting cardiac functions through the inhibition of NFkappaB signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKR1;Q6VVW6;Q8BPG3;Q8CIL2;Q9CT29;Q9D026", "ec_number_list": [], "go_molecular_function": "GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005634 nucleus", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9QYI3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQQ7-1", "uniprot_id": [ { "id": "AT5F1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQQ7", "type": "external" } ], "mass": 28949.0, "length": 256, "protein_name": "ATP synthase peripheral stalk subunit b, mitochondrial", "gene_name": "Atp5pb", "organism": "Mouse", "refseq_name": "ATP synthase peripheral stalk subunit b, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_033855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033855", "type": "external" } ], "gene_names_uniprotkb": "Atp5pb; Atp5f1", "gene_names_refseq": "Atp5f1; Atp5pb", "protein_names_uniprotkb": "ATP synthase peripheral stalk subunit b, mitochondrial; ATP synthase F(0) complex subunit B1, mitochondrial; ATP synthase peripheral stalk-membrane subunit b; ATP synthase subunit b; ATPase subunit b", "protein_names_refseq": "ATP synthase F(0) complex subunit B1, mitochondrial; ATP synthase peripheral stalk subunit b, mitochondrial isoform 1; ATP synthase peripheral stalk subunit b, mitochondrial; ATP synthase subunit b, mitochondrial; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1; ATPase subunit b", "tax_id": 10090, "disease": "clear cell renal cell carcinoma (Disease Ontology:DOID:4467); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:11950); (R-MMU-163210); (R-MMU-8949613)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "21750661;23576753;23806337;31219806;32152506;33300544;34428180;36210013;36288343;37453647;37507081;39627609;39927985", "class_list": "", "function": "Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0046933 proton-transporting ATP synthase activity, rotational mechanism;GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0043209 myelin sheath;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis;GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9CQQ7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C7T6-1", "uniprot_id": [ { "id": "ATX1L_MOUSE", "url": "https://www.uniprot.org/uniprot/P0C7T6", "type": "external" } ], "mass": 73374.0, "length": 687, "protein_name": "Ataxin-1-like", "gene_name": "Atxn1l", "organism": "Mouse", "refseq_name": "ataxin-1-like", "refseq_ac": [ { "id": "NP_001074399", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074399", "type": "external" } ], "gene_names_uniprotkb": "Atxn1l; Boat", "gene_names_refseq": "Atxn1l; Boat; C330011L24Rik; D6Mgi37; D8Ertd587e", "protein_names_uniprotkb": "Ataxin-1-like; Brother of ataxin-1", "protein_names_refseq": "ataxin-1-like; brother of ataxin-1", "tax_id": 10090, "disease": "autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441)", "pathway": " (mmu:52335)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "16121196;17322884;21183079;21750661;22517741;28288114;31599954;32782141;32848054;34678516;34887587;35822049;36852467;40885482;40997131", "class_list": "", "function": "Boat is an in vivo binding partner of ataxin-1 whose altered expression in Purkinje cells may contribute to their degeneration in causes spinocerebellar ataxia type 1 animals, [RefSeq, PubMed]; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (By similarity). Can suppress the cytotoxicity of ATXN1 in spinocerebellar ataxia type 1 (SCA1) (PubMed:16121196). In concert with CIC and ATXN1, involved in brain development (PubMed:28288114)., [UniProtKB, PubMed, PubMed, UniProtKB]; Results provide genetic evidence that the selective neuropathology of Spinocerebellar ataxia type 1 arises from modulation of a core functional activity of ataxin-1, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 12, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 12, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 12, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0031208 POZ domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030425 dendrite", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007612 learning;GO:0007613 memory;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P0C7T6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VD46-1", "uniprot_id": [ { "id": "ASZ1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VD46", "type": "external" } ], "mass": 52984.0, "length": 475, "protein_name": "Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1", "gene_name": "Asz1", "organism": "Mouse", "refseq_name": "ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1", "refseq_ac": [ { "id": "NP_076218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076218", "type": "external" } ], "gene_names_uniprotkb": "Asz1; Gasz", "gene_names_refseq": "4933400N19Rik; Asz1; Gasz; ORF3", "protein_names_uniprotkb": "Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1; Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein", "protein_names_refseq": "ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1; germ cell-specific ankyrin, SAM and basic leucine zipper domain containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:74068)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10655503;12040005;19730684;21183079;21750661;26711429;30084848;35095021", "class_list": "", "function": "Disruption of piRNA machinery by deletion of ASZ1/GASZ results in the expression of aberrant chimeric transcripts in gonocytes., [RefSeq, PubMed]; GASZ interacts with itself at the outer membrane of mitochondria and promotes mitofusion in a mitofusin/MFN-dependent manner. GASZ contains a functional mitochondrial targeting signal ., [RefSeq, PubMed]; GASZ is essential for meiosis and suppression of retrotransposon expression in the male germ cells. Erratum:[PLoS Genet. 2009 Dec;5(12). doi: 10.1371/annotation/20bf08d1-07e9-451e-b079-166832ebe158], [RefSeq, PubMed]; Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G3X8S0;Q6PD92;Q9JKQ7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0071546 pi-body", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007281 germ cell development;GO:0007140 male meiotic nuclear division;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0010526 transposable element silencing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VD46-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R429-1", "uniprot_id": [ { "id": "AT2A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R429", "type": "external" } ], "mass": 109425.0, "length": 994, "protein_name": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 1", "gene_name": "Atp2a1", "organism": "Mouse", "refseq_name": "sarcoplasmic/endoplasmic reticulum calcium ATPase 1", "refseq_ac": [ { "id": "NP_031530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031530", "type": "external" } ], "gene_names_uniprotkb": "Atp2a1", "gene_names_refseq": "Atp2a1; SERCA1", "protein_names_uniprotkb": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; 7.2.2.10; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; SERCA1; SR Ca(2+)-ATPase 1", "protein_names_refseq": "SR Ca(2+)-ATPase 1; calcium pump 1; endoplasmic reticulum class 1/2 Ca(2+) ATPase; sarcoplasmic/endoplasmic reticulum calcium ATPase 1", "tax_id": 10090, "disease": "Brody myopathy (Disease Ontology:DOID:0050692); heart disease (Disease Ontology:DOID:114); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:11937); (R-MMU-418359); (R-MMU-5578775); (R-MMU-936837)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "21697544;21750661;22645316;22961106;25640239;26816378;27923914;35235340;35820727;37749267;39927985", "class_list": "", "function": "Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum (PubMed:21697544, PubMed:22961106, PubMed:25640239, PubMed:26816378, PubMed:27923914). Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:21697544, PubMed:22961106, PubMed:25640239, PubMed:26816378)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; SERAC1 is a component of the mitochondrial serine transporter complex required for the maintenance of mitochondrial DNA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" }, { "id": "7.2.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.8", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0016887 ATP hydrolysis activity;GO:0005509 calcium ion binding;GO:0005388 P-type calcium transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1902082 positive regulation of calcium ion import into sarcoplasmic reticulum;GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0051659 maintenance of mitochondrion location;GO:0070588 calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8R429-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55143-1", "uniprot_id": [ { "id": "AT2A2_MOUSE", "url": "https://www.uniprot.org/uniprot/O55143", "type": "external" } ], "mass": 114858.0, "length": 1044, "protein_name": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "gene_name": "Atp2a2", "organism": "Mouse", "refseq_name": "sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b", "refseq_ac": [ { "id": "NP_001103610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103610", "type": "external" } ], "gene_names_uniprotkb": "Atp2a2", "gene_names_refseq": "9530097L16Rik; Atp2a2; D5Wsu150e; SERCA2B; SERCA2; Serca2a; mKIAA4195", "protein_names_uniprotkb": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; 7.2.2.10; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; SERCA2; SR Ca(2+)-ATPase 2", "protein_names_refseq": "SR Ca(2+)-ATPase 2; calcium pump 2; endoplasmic reticulum class 1/2 Ca(2+) ATPase; sarco/endoplasmic reticulum Ca2+-ATPase 2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "tax_id": 10090, "disease": "acrokeratosis verruciformis (Disease Ontology:DOID:0050606); Brody myopathy (Disease Ontology:DOID:0050692); essential hypertension (Disease Ontology:DOID:10825); heart disease (Disease Ontology:DOID:114); abdominal obesity-metabolic syndrome 1 (Disease Ontology:DOID:14221); hypothyroidism (Disease Ontology:DOID:1459); keratosis follicularis (Disease Ontology:DOID:2734); euthyroid sick syndrome (Disease Ontology:DOID:2856); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:11938); (R-MMU-418359); (R-MMU-5578775); (R-MMU-936837)", "pathway_count": 4, "publication_count": 39, "publication_id_list": "10656932;14749390;17242355;18403730;19144319;21183079;22355118;22645316;22872234;22874425;22971924;23395171;24788674;25333865;25428506;25428507;25605945;27923914;28890335;30084848;31219806;31449798;31599954;32116663;32367034;32375037;32973183;33300544;34203471;34428180;35036403;35820727;36210013;36288343;37453647;37507081;38927078;39195964;39927985", "class_list": "", "function": "Deubiquitinase JOSD2 improves calcium handling and attenuates cardiac hypertrophy and dysfunction by stabilizing SERCA2a in cardiomyocytes., [RefSeq, PubMed]; Involved in the regulation of the contraction/relaxation cycle (PubMed:23395171). Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation (PubMed:23395171). Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation (PubMed:23395171)., [UniProtKB, PubMed]; Perimenopause Decreases SERCA2a Activity in the Hearts of a Mouse Model of Ovarian Failure. Publication Status: Online-Only, [RefSeq, PubMed]; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes (By similarity). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9R2A9;Q9WUT5", "ec_number_list": [ { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" }, { "id": "7.2.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.8", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0005246 calcium channel regulator activity;GO:0016887 ATP hydrolysis activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0031234 extrinsic component of cytoplasmic side of plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0034599 cellular response to oxidative stress;GO:0014883 transition between fast and slow fiber", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "O55143-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28658-1", "uniprot_id": [ { "id": "ATX10_MOUSE", "url": "https://www.uniprot.org/uniprot/P28658", "type": "external" } ], "mass": 53707.0, "length": 475, "protein_name": "Ataxin-10", "gene_name": "Atxn10", "organism": "Mouse", "refseq_name": "ataxin-10", "refseq_ac": [ { "id": "NP_058539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058539", "type": "external" } ], "gene_names_uniprotkb": "Atxn10; Sca10", "gene_names_refseq": "Atxn10; E46; Sca10; TEG-169; Tex169", "protein_names_uniprotkb": "Ataxin-10; Brain protein E46; Spinocerebellar ataxia type 10 protein homolog", "protein_names_refseq": "ataxin-10; brain protein E46; spinocerebellar ataxia type 10 protein homolog; testis expressed gene 169", "tax_id": 10090, "disease": "spinocerebellar ataxia 10 (Disease Ontology:DOID:0050960)", "pathway": " (mmu:54138)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10967031;12106288;15201271;16182253;18299400;19224205;20173027;20484733;21952136;22872234;24129315;25428506;25428507;25605945;30084848;30779550;31599954;32152506;33649389;34203471;34428180;34970537;35820727;35984892;36210013;37507081;37828378;9285407", "class_list": "", "function": "Ataxin-10, encoded by the SCA10 gene, interacts with O-linked N-acetylglucosamine in vivo and is modified by O-linked glycosylation in the insulinoma MIN6 cell line., [RefSeq, PubMed]; May play a role in the regulation of cytokinesis (PubMed:34970537). May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons (By similarity). Does not appear to play a major role in ciliogenesis (PubMed:34970537)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543S3;Q99LP5;Q9D1I1", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0030425 dendrite", "go_biological_process": "GO:0007399 nervous system development;GO:0031175 neuron projection development;GO:0051301 cell division;GO:0060271 cilium assembly;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P28658-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56382-1", "uniprot_id": [ { "id": "ATP5E_MOUSE", "url": "https://www.uniprot.org/uniprot/P56382", "type": "external" } ], "mass": 5838.0, "length": 52, "protein_name": "ATP synthase F(1) complex subunit epsilon, mitochondrial", "gene_name": "Atp5f1e", "organism": "Mouse", "refseq_name": "ATP synthase F(1) complex subunit epsilon, mitochondrial", "refseq_ac": [ { "id": "NP_080259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080259", "type": "external" } ], "gene_names_uniprotkb": "Atp5f1e; Atp5e", "gene_names_refseq": "2410043G19Rik; ATPE; Atp5e; Atp5f1e", "protein_names_uniprotkb": "ATP synthase F(1) complex subunit epsilon, mitochondrial; ATP synthase F1 subunit epsilon; ATPase subunit epsilon", "protein_names_refseq": "ATP synthase F(1) complex subunit epsilon, mitochondrial; ATP synthase epsilon chain, mitochondrial; ATP synthase subunit epsilon, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit; ATPase subunit epsilon; mitochondrial ATP synthase epsilon subunit", "tax_id": 10090, "disease": "mitochondrial complex V (ATP synthase) deficiency nuclear type 3 (Disease Ontology:DOID:0060332)", "pathway": " (mmu:67126); (R-MMU-163210); (R-MMU-8949613)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "23576753;23806337;25428506;25605945;26495903;30084848;30779550;31219806;33300544;34428180;35820727;36288343;37828378", "class_list": "", "function": "Subunit epsilon, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). May be essential for the assembly of F(1) and may play an important role in the incorporation of the hydrophobic subunit c into the F(1)-c oligomer rotor of the mitochondrial ATP synthase complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008553 P-type proton-exporting transporter activity;GO:0044877 protein-containing complex binding;GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis;GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P56382-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61137-1", "uniprot_id": [ { "id": "ASTN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61137", "type": "external" } ], "mass": 144884.0, "length": 1302, "protein_name": "Astrotactin-1", "gene_name": "Astn1", "organism": "Mouse", "refseq_name": "astrotactin-1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001192133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192133", "type": "external" } ], "gene_names_uniprotkb": "Astn1; Astn; Kiaa0289", "gene_names_refseq": "Astn1; Astn; GC14; mKIAA0289", "protein_names_uniprotkb": "Astrotactin-1; Neuronal migration protein GC14", "protein_names_refseq": "astrotactin-1 isoform 1 precursor; neuronal migration protein GC14", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:11899)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11861479;20573900;21183079;21750661;22645316;24129315;30696770;33300544;40885482;8602532", "class_list": "", "function": "Astrotactin is required for appropriate and timely migration of cerebellar granule cells., [RefSeq, PubMed]; Differences in the degree of Astn1 and Astn2 maturation possibly contribute to the higher levels of the C-terminal domain of Astn1 detected on neuronal membranes of the central nervous system, [RefSeq, PubMed]; Neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum. Required for normal rate of migration of granule cells during brain development and for normal cerebellum development., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "G5E8A1;Q505A0;Q7TQG3;Q8CHH2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005768 endosome;GO:0016020 membrane;GO:0043204 perikaryon;GO:0009897 external side of plasma membrane;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0007626 locomotory behavior;GO:0016477 cell migration;GO:0001764 neuron migration;GO:0098609 cell-cell adhesion;GO:0007158 neuron cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q61137-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6Q477-1", "uniprot_id": [ { "id": "AT2B4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6Q477", "type": "external" } ], "mass": 133069.0, "length": 1205, "protein_name": "Plasma membrane calcium-transporting ATPase 4", "gene_name": "Atp2b4", "organism": "Mouse", "refseq_name": "plasma membrane calcium-transporting ATPase 4 isoform a", "refseq_ac": [ { "id": "NP_001161421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161421", "type": "external" } ], "gene_names_uniprotkb": "Atp2b4", "gene_names_refseq": "Atp2b4; Pmca4", "protein_names_uniprotkb": "Plasma membrane calcium-transporting ATPase 4; 7.2.2.10; PMCA4", "protein_names_refseq": "plasma membrane calcium-transporting ATPase 4 isoform a; plasma membrane calcium-transporting ATPase 4", "tax_id": 10090, "disease": "Hailey-Hailey disease (Disease Ontology:DOID:0050429); pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714); dystonia (Disease Ontology:DOID:543)", "pathway": " (mmu:381290); (R-MMU-418359); (R-MMU-5578775); (R-MMU-936837)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;12209837;15078889;19144319;21183079;21750661;21952136;22645316;24129315;31219806;34428180;34678516;36210013;38666459", "class_list": "", "function": "Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. By regulating sperm cell calcium homeostasis, may play a role in sperm motility., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; Catalyzes the hydrolysis of ATP coupled with the transport of calcium., [UniProtKB, UniProtKB, UniProtKB]; Genetic Screening of Haploid Neural Stem Cells Reveals that Nfkbia and Atp2b4 are Key Regulators of Oxidative Stress in Neural Precursors., [RefSeq, PubMed]; PMCA4 has a pivotal role in the regulation of sperm function and intracellular Ca(2+) levels, [RefSeq, PubMed]; PMCA4 was found to be selectively expressed in both synaptic layers of the retina, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q32ME1", "ec_number_list": [ { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" }, { "id": "7.2.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0003407 neural retina development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0010629 negative regulation of gene expression;GO:0006816 calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q6Q477-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDN2-1", "uniprot_id": [ { "id": "AT1A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDN2", "type": "external" } ], "mass": 112982.0, "length": 1023, "protein_name": "Sodium/potassium-transporting ATPase subunit alpha-1", "gene_name": "Atp1a1", "organism": "Mouse", "refseq_name": "sodium/potassium-transporting ATPase subunit alpha-1", "refseq_ac": [ { "id": "NP_659149", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659149", "type": "external" } ], "gene_names_uniprotkb": "Atp1a1", "gene_names_refseq": "Atp1a1; Atpa-1", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit alpha-1; 7.2.2.13; Na(+)/K(+) ATPase alpha-1 subunit; Sodium pump subunit alpha-1", "protein_names_refseq": "Na(+)/K(+) ATPase alpha-1 subunit; sodium pump subunit alpha-1; sodium/potassium-transporting ATPase subunit alpha-1", "tax_id": 10090, "disease": "familial hemiplegic migraine (Disease Ontology:DOID:0060178); Charcot-Marie-Tooth disease type 2DD (Disease Ontology:DOID:0111558); sensorineural hearing loss (Disease Ontology:DOID:10003); hypertension (Disease Ontology:DOID:10763); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); nervous system disease (Disease Ontology:DOID:863); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (mmu:11928); (R-MMU-5578775); (R-MMU-936837)", "pathway_count": 3, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;15743908;16075062;17114649;17283221;17408578;18034455;21183079;22645316;23806337;24788674;25605945;26495903;26740625;28011936;30084848;31219806;32152506;33300544;34428180;35984892;36288343;37453647;37507081;39627609;40684658", "class_list": "", "function": "Catalytic subunit of the Na(+)/K(+)-ATPase pump that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle against electrochemical gradients. It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane (By similarity). This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function. Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (PubMed:17408578)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 8, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q91Z09", "ec_number_list": [ { "id": "7.2.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.13", "type": "external" }, { "id": "7.2.2.19", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.19", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0046982 protein heterodimerization activity;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0007231 osmosensory signaling pathway;GO:0055085 transmembrane transport;GO:0008217 regulation of blood pressure;GO:0002028 regulation of sodium ion transport;GO:0006883 intracellular sodium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q8VDN2-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPQ8-1", "uniprot_id": [ { "id": "ATP5L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPQ8", "type": "external" } ], "mass": 11425.0, "length": 103, "protein_name": "ATP synthase F(0) complex subunit g, mitochondrial", "gene_name": "Atp5mg", "organism": "Mouse", "refseq_name": "ATP synthase F(0) complex subunit g, mitochondrial", "refseq_ac": [ { "id": "NP_038823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038823", "type": "external" } ], "gene_names_uniprotkb": "Atp5mg; Atp5l", "gene_names_refseq": "4933437C06Rik; Atp5l; Atp5mg", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit g, mitochondrial; ATP synthase membrane subunit g; ATPase subunit g", "protein_names_refseq": "ATP synthase F(0) complex subunit g, mitochondrial; ATP synthase subunit g, mitochondrial; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G; ATPase subunit g; F1F0-ATP synthase g subunit", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:27425); (R-MMU-163210); (R-MMU-8949613); (R-MMU-9837999)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10361692;22645316;22872234;23576753;26495903;28011936;30084848;30779550;34428180;36288343;37453647;37507081;37828378", "class_list": "", "function": "Subunit g, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O70590;Q5M9M8", "ec_number_list": [], "go_molecular_function": "GO:0008553 P-type proton-exporting transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0097228 sperm principal piece;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9CPQ8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CVD2-1", "uniprot_id": [ { "id": "ATX3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CVD2", "type": "external" } ], "mass": 40533.0, "length": 355, "protein_name": "Ataxin-3", "gene_name": "Atxn3", "organism": "Mouse", "refseq_name": "ataxin-3 isoform 1", "refseq_ac": [ { "id": "NP_083981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083981", "type": "external" } ], "gene_names_uniprotkb": "Atxn3; Mjd", "gene_names_refseq": "2210008M02Rik; ATX3; Atxn3; MJD1; Mjd; Sca3; ataxin-3", "protein_names_uniprotkb": "Ataxin-3; 3.4.19.12; Machado-Joseph disease protein 1 homolog", "protein_names_refseq": "Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) homolog; ataxin-3 isoform 1; machado-Joseph disease protein 1 homolog", "tax_id": 10090, "disease": "late onset Parkinson's disease (Disease Ontology:DOID:0060892); Machado-Joseph disease (Disease Ontology:DOID:1440)", "pathway": " (mmu:110616); (R-MMU-5689877); (R-MMU-9615017)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "12486728;15345747;17242355;20347968;21183079;21750661;21855799;25428506;28445460;30779550;34428180", "class_list": "", "function": "Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (By similarity). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (PubMed:21855799). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (By similarity). Acts as a negative regulator of mTORC1 signaling in response to amino acid deprivation by mediating deubiquitination of RHEB, thereby promoting RHEB inactivation by the TSC-TBC complex (By similarity). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051117 ATPase binding;GO:0031625 ubiquitin protein ligase binding;GO:0042826 histone deacetylase binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0070536 protein K63-linked deubiquitination;GO:0034605 cellular response to heat", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CVD2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61140-1", "uniprot_id": [ { "id": "BCAR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61140", "type": "external" } ], "mass": 94285.0, "length": 874, "protein_name": "Breast cancer anti-estrogen resistance protein 1", "gene_name": "Bcar1", "organism": "Mouse", "refseq_name": "breast cancer anti-estrogen resistance protein 1 isoform A", "refseq_ac": [ { "id": "NP_001185768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185768", "type": "external" } ], "gene_names_uniprotkb": "Bcar1; Cas; Crkas", "gene_names_refseq": "Bcar1; Cas; Crkas", "protein_names_uniprotkb": "Breast cancer anti-estrogen resistance protein 1; CRK-associated substrate; p130cas", "protein_names_refseq": "CRK-associated substrate; breast cancer anti-estrogen resistance protein 1 isoform A; breast cancer anti-estrogen resistance protein 1; p130 Cas; p130cas; v-crk-associated tyrosine kinase substrate", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612); breast ductal carcinoma (Disease Ontology:DOID:3007)", "pathway": " (mmu:12927); (R-MMU-186763); (R-MMU-372708); (R-MMU-4420097); (R-MMU-8849471)", "pathway_count": 5, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10438950;10692442;10739664;10896938;12486027;12972425;15592455;17174122;18034455;19131326;19365570;20881139;21183079;22801373;25499443;30422386;36991029;40021952;7479864", "class_list": "", "function": "Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (By similarity). Implicated in induction of cell migration and cell branching (PubMed:25499443). Involved in the BCAR3-mediated inhibition of TGFB signaling (PubMed:25499443)., [UniProtKB, UniProtKB, PubMed]; P130Cas is required for androgen-dependent postnatal development regulation of submandibular glands. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q60869;Q6PFF9", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0086100 endothelin receptor signaling pathway;GO:1990859 cellular response to endothelin;GO:0007015 actin filament organization;GO:0007155 cell adhesion;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q61140-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NS45-1", "uniprot_id": [ { "id": "CCD66_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NS45", "type": "external" } ], "mass": 107372.0, "length": 935, "protein_name": "Coiled-coil domain-containing protein 66", "gene_name": "Ccdc66", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 66", "refseq_ac": [ { "id": "NP_796085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796085", "type": "external" } ], "gene_names_uniprotkb": "Ccdc66", "gene_names_refseq": "Ccdc66; E230015L20Rik", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 66", "protein_names_refseq": "coiled-coil domain-containing protein 66", "tax_id": 10090, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:320234)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17242355;19777273;21183079;21680557;34428180;36852467;37852749;40729374", "class_list": "", "function": "CCDC66 mutations are associated with high myopia through affected cell mitosis. Publication Status: Online-Only, [RefSeq, PubMed]; Lack of protein CCDC66 causes early, slow progressive generalized progressive retinal atrophy in the Ccdc66 mutant mouse model., [RefSeq, PubMed]; Microtubule-binding protein required for ciliogenesis. May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites. Required for the assembly of signaling-competent cilia with proper structure and length. Mediates this function in part by regulating transition zone assembly and basal body recruitment of the IFT-B complex. Cooperates with the ciliopathy proteins CSPP1 and CEP104 during cilium length regulation (By similarity). Essential for cilium elongation, maintaining ciliary length and stability, and inhibiting disassembly (likely by stabilizing the axoneme) (PubMed:40729374). Also plays a role in ciliary Hedgehog pathway activation (PubMed:40729374). Plays two important roles during cell division. First, is required for mitotic progression via regulation of spindle assembly, organization and orientation, levels of spindle microtubules (MTs), kinetochore-fiber integrity, and chromosome alignment (By similarity). Second, functions during cytokinesis in part by regulating assembly and organization of central spindle and midbody MTs (By similarity). Plays a role in retina morphogenesis and/or homeostasis (PubMed:21680557)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3ULU6;Q8C304;Q8C6T6", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:1902850 microtubule cytoskeleton organization involved in mitosis;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0001895 retina homeostasis;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6NS45-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQ32-1", "uniprot_id": [ { "id": "BCAP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQ32", "type": "external" } ], "mass": 90928.0, "length": 811, "protein_name": "Phosphoinositide 3-kinase adapter protein 1", "gene_name": "Pik3ap1", "organism": "Mouse", "refseq_name": "phosphoinositide 3-kinase adapter protein 1", "refseq_ac": [ { "id": "NP_113553", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113553", "type": "external" } ], "gene_names_uniprotkb": "Pik3ap1; Bcap", "gene_names_refseq": "1810044J04Rik; BCAP; Pik3ap1", "protein_names_uniprotkb": "Phosphoinositide 3-kinase adapter protein 1; B-cell adapter for phosphoinositide 3-kinase; B-cell phosphoinositide 3-kinase adapter protein 1", "protein_names_refseq": "B cell phosphoinositide 3-kinase adaptor; B-cell adapter for phosphoinositide 3-kinase; B-cell phosphoinositide 3-kinase adapter protein 1; phosphoinositide 3-kinase adapter protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:83490); (R-MMU-1257604); (R-MMU-6811558); (R-MMU-983695)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "11163197;11781242;11877477;12518443;12767830;12833156;18025150;18250455;18299400;18337558;20728433;22187458;22187460;26495903;34428180;35820727;39627609", "class_list": "", "function": "Plays an immunoregulatory role in B cell development and function--review Review article, [RefSeq, PubMed]; Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q2KHL6;Q3TBW6;Q3TC39;Q3U5J3;Q8BN25;Q8C2Y4", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0034123 positive regulation of toll-like receptor signaling pathway;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0050727 regulation of inflammatory response;GO:0034122 negative regulation of toll-like receptor signaling pathway;GO:0034134 toll-like receptor 2 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9EQ32-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C6E0-1", "uniprot_id": [ { "id": "CFA36_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C6E0", "type": "external" } ], "mass": 39600.0, "length": 343, "protein_name": "Cilia- and flagella-associated protein 36", "gene_name": "Cfap36", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 36", "refseq_ac": [ { "id": "NP_080016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080016", "type": "external" } ], "gene_names_uniprotkb": "Cfap36; Ccdc104", "gene_names_refseq": "2300003H10; 4931428D14Rik; Ccdc104; Cfap36", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 36; Coiled-coil domain-containing protein 104", "protein_names_refseq": "cilia- and flagella-associated protein 36; coiled-coil domain containing 104; coiled-coil domain-containing protein 104", "tax_id": 10090, "disease": "", "pathway": " (mmu:216618)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21750661;26455799;32782141;32848054", "class_list": "", "function": "Complex structure shows Cfap36 binding to conserved LLxILxxL N-term motif of Arl3., [RefSeq, PubMed]; May act as an effector for ARL3., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9CWQ4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0031514 motile cilium;GO:0005930 axoneme;GO:0097546 ciliary base;GO:0035869 ciliary transition zone", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8C6E0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q569Z5-1", "uniprot_id": [ { "id": "DDX46_MOUSE", "url": "https://www.uniprot.org/uniprot/Q569Z5", "type": "external" } ], "mass": 117448.0, "length": 1032, "protein_name": "Probable ATP-dependent RNA helicase DDX46", "gene_name": "Ddx46", "organism": "Mouse", "refseq_name": "probable ATP-dependent RNA helicase DDX46", "refseq_ac": [ { "id": "NP_001268984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268984", "type": "external" } ], "gene_names_uniprotkb": "Ddx46; Kiaa0801", "gene_names_refseq": "2200005K02Rik; 8430438J23Rik; Ddx46; mKIAA0801", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX46; 3.6.4.13; DEAD box protein 46", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 46; DEAD box polypeptide 46; DEAD box protein 46; probable ATP-dependent RNA helicase DDX46", "tax_id": 10090, "disease": "", "pathway": " (mmu:212880); (R-MMU-72163); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "19144319;21183079;21750661;23806337;25428506;28846086;30084848;30779550;31219806;34428180;39627609;41176131", "class_list": "", "function": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site., [UniProtKB, UniProtKB]; DDX46 inhibits antiviral innate responses by entrapping selected antiviral transcripts in the nucleus by erasing their m(6)A modification, a modification normally required for export from the nucleus and translation. Erratum:[Nat Immunol. 2017 Nov 16;18(12):1361. doi: 10.1038/ni1217-1361a. PMID: 29144498], [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZQ42;Q8R0R6", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0001650 fibrillar center;GO:0015030 Cajal body;GO:0005684 U2-type spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:1903241 U2-type prespliceosome assembly", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q569Z5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97465-1", "uniprot_id": [ { "id": "DOK1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97465", "type": "external" } ], "mass": 52452.0, "length": 482, "protein_name": "Docking protein 1", "gene_name": "Dok1", "organism": "Mouse", "refseq_name": "docking protein 1 isoform 1", "refseq_ac": [ { "id": "NP_034200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034200", "type": "external" } ], "gene_names_uniprotkb": "Dok1; Dok", "gene_names_refseq": "Dok1; p62DOK", "protein_names_uniprotkb": "Docking protein 1; Downstream of tyrosine kinase 1; p62(dok)", "protein_names_refseq": "docking protein 1 isoform 1; downstream of tyrosine kinase 1; p62(dok)", "tax_id": 10090, "disease": "", "pathway": " (mmu:13448); (R-MMU-8849469); (R-MMU-8853659)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "10640270;10822173;11031258;14607833;14747716;15148308;15592455;17947660;18515860;19131326;19144319;21183079;21750661;27926878;28490594;29548825;38956389;9008161;9872994;9927484", "class_list": "", "function": "DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity)., [UniProtKB]; DOK1 and DOK2 regulate CD8 T cell signaling and memory formation without affecting tumor cell killing. Publication Status: Online-Only, [RefSeq, PubMed]; Findings demonstrate that Dok-3 and Dok-1/-2 play distinctive but cooperative roles in osteoclastogenesis and protect mice from osteopenia, providing physiological and pathophysiological insight into bone homeostasis., [RefSeq, PubMed]; In the absence of PAG, Csk becomes more associated with alternative partners; i.e., phosphatase PTPN22 and Dok adaptors. Combining PAG deficiency with PTPN22 or Dok adaptor deficiency further enhances effector T cell responses. Unlike PAG, Cbl ubiquitin ligases inhibit the activation of naive, but not of effector, T cells., [RefSeq, PubMed]; Thus, Dok-1 and Dok-2 promote survival of glycoprotein B-specific CD8(+) T cells in trigeminal ganglia latently infected with herpes simplex virus 1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9R213", "ec_number_list": [], "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0038145 macrophage colony-stimulating factor signaling pathway;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0035556 intracellular signal transduction;GO:0007265 Ras protein signal transduction;GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P97465-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7K5-1", "uniprot_id": [ { "id": "DMAC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7K5", "type": "external" } ], "mass": 29179.0, "length": 258, "protein_name": "Distal membrane-arm assembly complex protein 2", "gene_name": "Dmac2", "organism": "Mouse", "refseq_name": "distal membrane-arm assembly complex protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001277416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277416", "type": "external" } ], "gene_names_uniprotkb": "Dmac2; Atp5sl", "gene_names_refseq": "2310004L02Rik; Atp5sl; C030044E10Rik; Dmac2", "protein_names_uniprotkb": "Distal membrane-arm assembly complex protein 2; ATP synthase subunit s-like protein", "protein_names_refseq": "ATP synthase subunit s-like protein; ATP5S-like; distal membrane-arm assembly complex protein 2 isoform 1; distal membrane-arm assembly complex protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66349); (R-MMU-6799198)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "18614015;21750661;34428180", "class_list": "", "function": "Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D7K5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59764-1", "uniprot_id": [ { "id": "DOCK4_MOUSE", "url": "https://www.uniprot.org/uniprot/P59764", "type": "external" } ], "mass": 226550.0, "length": 1978, "protein_name": "Dedicator of cytokinesis protein 4", "gene_name": "Dock4", "organism": "Mouse", "refseq_name": "dedicator of cytokinesis protein 4", "refseq_ac": [ { "id": "NP_766391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766391", "type": "external" } ], "gene_names_uniprotkb": "Dock4; Kiaa0716", "gene_names_refseq": "5330406C03; 6330411N01Rik; C030023J22; Dock4; mKIAA0716", "protein_names_uniprotkb": "Dedicator of cytokinesis protein 4", "protein_names_refseq": "dedicator of cytokinesis protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:238130); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013408); (R-MMU-983231)", "pathway_count": 5, "publication_count": 20, "publication_id_list": "16464467;18034455;21183079;21750661;22517741;22645316;30084848;31219806;32782141;33300544;34428180;34678516;35302184;35477279;35635601;36210013;36852467;37828378;40021952;40885482", "class_list": "", "function": "DOCK4 Regulation of Rho GTPases Mediates Pulmonary Vascular Barrier Function., [RefSeq, PubMed]; DOCK4 regulates ghrelin production in gastric X/A-like cells., [RefSeq, PubMed]; Deficiency of Autism-Related Gene Dock4 Leads to Impaired Spatial Memory and Hippocampal Function in Mice at Late Middle Age., [RefSeq, PubMed]; Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form. Involved in regulation of adherens junction between cells. Plays a role in cell migration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Has a higher guanine nucleotide exchange factor activity compared to other isoforms., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B2RUG6", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0017124 SH3 domain binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0060326 cell chemotaxis;GO:1904754 positive regulation of vascular associated smooth muscle cell migration;GO:1904694 negative regulation of vascular associated smooth muscle contraction;GO:0150052 regulation of postsynapse assembly", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P59764-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JMC8-1", "uniprot_id": [ { "id": "E41LB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JMC8", "type": "external" } ], "mass": 59564.0, "length": 527, "protein_name": "Band 4.1-like protein 4B", "gene_name": "Epb41l4b", "organism": "Mouse", "refseq_name": "band 4.1-like protein 4B isoform 1", "refseq_ac": [ { "id": "NP_062300", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062300", "type": "external" } ], "gene_names_uniprotkb": "Epb41l4b; Ehm2; Epb4.1l4b; Lulu2", "gene_names_refseq": "6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b; Epb41l4b; Lulu2", "protein_names_uniprotkb": "Band 4.1-like protein 4B; Erythrocyte membrane protein band 4.1-like 4B; Protein EHM2", "protein_names_refseq": "band 4.1-like protein 4B isoform 1; band 4.1-like protein 4B; erythrocyte protein band 4.1-like 4b; expressed in high-metastatic cells", "tax_id": 10090, "disease": "", "pathway": " (mmu:54357)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10783258;21750661;22006950;22645316;31219806;34428180", "class_list": "", "function": "Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (PubMed:22006950). Involved in the regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (By similarity). May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ALK7", "ec_number_list": [], "go_molecular_function": "GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0045785 positive regulation of cell adhesion;GO:0051549 positive regulation of keratinocyte migration;GO:0031032 actomyosin structure organization;GO:0042060 wound healing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JMC8-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AZP2-1", "uniprot_id": [ { "id": "DLGP4_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AZP2", "type": "external" } ], "mass": 108037.0, "length": 992, "protein_name": "Disks large-associated protein 4", "gene_name": "Dlgap4", "organism": "Mouse", "refseq_name": "disks large-associated protein 4 isoform b", "refseq_ac": [ { "id": "NP_001035952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035952", "type": "external" } ], "gene_names_uniprotkb": "Dlgap4; Kiaa0964; Sapap4", "gene_names_refseq": "DAP-4; DAP4; Dlgap4; SAPAP-4; Sapap4; WBP16", "protein_names_uniprotkb": "Disks large-associated protein 4; DAP-4; PSD-95/SAP90-binding protein 4; SAP90/PSD-95-associated protein 4; SAPAP-4", "protein_names_refseq": "PSD-95/SAP90-binding protein 4; SAP90/PSD-95-associated protein 4; WW domain-binding protein 16; discs, large homolog-associated protein 4; disks large-associated protein 4 isoform b; disks large-associated protein 4", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:228836); (R-MMU-6794361)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;15024750;15345747;16452087;17114649;21183079;21750661;22517741;22645316;24129315;28528544;30322620;30664629;32848054;33300544;34428180;35368073;35585091;37828378;40885482", "class_list": "", "function": "May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane (By similarity)., [UniProtKB]; Novel role of the synaptic scaffold protein Dlgap4 in ventricular surface integrity and neuronal migration during cortical development. Publication Status: Online-Only, [RefSeq, PubMed]; Sapap4 deficiency leads to postsynaptic defects and abnormal behaviors relevant to hyperkinetic neuropsychiatric disorder in mice., [RefSeq, PubMed]; The behavioural alterations of SAPAP4-deficient mice are associated with dramatic changes in synapse morphology, function and plasticity, indicating that SAPAP4 is critical for the development of functional neuronal networks Publication Status: Online-Only, [RefSeq, PubMed]; The findings demonstrate that SAPAP4 plays a critical role in in the synaptic function of the nucleus accumbens., [RefSeq, PubMed]; This gene encodes a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. The encoded protein may play a role in synapse organization and neuronal signalling. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Mar 2013]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "B1AZP3;B7ZNS1;Q3KQQ8;Q6PD44;Q6XBF1;Q80TN3;Q8R3U9", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0016020 membrane;GO:0030425 dendrite;GO:0031594 neuromuscular junction;GO:0043025 neuronal cell body", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission;GO:0023052 signaling;GO:0090128 regulation of synapse maturation;GO:0099010 modification of postsynaptic structure", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "B1AZP2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08749-1", "uniprot_id": [ { "id": "DLDH_MOUSE", "url": "https://www.uniprot.org/uniprot/O08749", "type": "external" } ], "mass": 54272.0, "length": 509, "protein_name": "Dihydrolipoyl dehydrogenase, mitochondrial", "gene_name": "Dld", "organism": "Mouse", "refseq_name": "dihydrolipoyl dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_031887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031887", "type": "external" } ], "gene_names_uniprotkb": "Dld", "gene_names_refseq": "Dld", "protein_names_uniprotkb": "Dihydrolipoyl dehydrogenase, mitochondrial; 1.8.1.4; Dihydrolipoamide dehydrogenase", "protein_names_refseq": "branched chain alpha-keto acid dehydrogenase complex subunit E3; dihydrolipoyl dehydrogenase, mitochondrial precursor; dihydrolipoyl dehydrogenase, mitochondrial", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); dihydrolipoamide dehydrogenase deficiency (Disease Ontology:DOID:0061204)", "pathway": " (mmu:13382); (R-MMU-204174); (R-MMU-5362517); (R-MMU-6783984); (R-MMU-70895); (R-MMU-9837999); (R-MMU-9853506); (R-MMU-9858328); (R-MMU-9859138); (R-MMU-9861559)", "pathway_count": 10, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;15009635;15888450;17404228;21183079;23576753;23806337;25605945;26495903;28011936;30084848;34418053;34428180;36288343;36854377;37453647;37507081;37828378;39927985;40684658;9169128", "class_list": "", "function": "Human, mouse, and pig Dld has moonlighting function as a protease in addition to its canonical function as a a dehydrogenase., [RefSeq, PubMed]; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity). In monomeric form may have additional moonlighting function as serine protease (PubMed:17404228). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity). The pyruvate dehydrogenase (PDH) complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). The E3 subunit catalyzes reoxidation of the dihydrolipoyl moiety on lipoyl-bearing domains (LBDs) of E2 with NAD+ as the ultimate electron acceptor (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Mice that are deficient in dihydrolipoamide dehydrogenase show increased vulnerability to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), malonate and 3-nitropropionic acid, which have been used in models of Parkinson disease and Huntington disease, [RefSeq, PubMed]; This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TG55;Q3U5W5;Q3UWP7;Q99LD3", "ec_number_list": [ { "id": "1.2.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.-", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.4", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "3.1.3.43", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.43", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "2.3.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.12", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.61", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.61", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0051287 NAD binding;GO:0004148 dihydrolipoyl dehydrogenase (NADH) activity;GO:0043544 lipoamide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005929 cilium", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006103 2-oxoglutarate metabolic process;GO:0006508 proteolysis;GO:0042391 regulation of membrane potential;GO:0009083 branched-chain amino acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "O08749-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70469-1", "uniprot_id": [ { "id": "DOK2_MOUSE", "url": "https://www.uniprot.org/uniprot/O70469", "type": "external" } ], "mass": 45522.0, "length": 412, "protein_name": "Docking protein 2", "gene_name": "Dok2", "organism": "Mouse", "refseq_name": "docking protein 2 isoform 1", "refseq_ac": [ { "id": "NP_034201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034201", "type": "external" } ], "gene_names_uniprotkb": "Dok2; Frip", "gene_names_refseq": "Dok2; DokR; Frip; dok-R", "protein_names_uniprotkb": "Docking protein 2; Dok-R; Dok-related protein; Downstream of tyrosine kinase 2; FRIP; IL-four receptor-interacting protein; p56(dok-2)", "protein_names_refseq": "IL-four receptor-interacting protein; docking protein 2 isoform 1; dok-related protein; downstream of tyrosine kinase 2; p56(dok-2)", "tax_id": 10090, "disease": "malignant astrocytoma (Disease Ontology:DOID:3069)", "pathway": " (mmu:13449); (R-MMU-210993); (R-MMU-8853659)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10508618;11470823;11689432;12665569;29548825;30475228;34505522;35820727;38956389;9478921;9697832;9764820", "class_list": "", "function": "Compound-heterozygous deletion of Dok2 and Dusp4 in mice resulted in lung tumorigenesis with short latency and high incidence, and that their co-deletion synergistically activated MAPK signaling and promoted cell proliferation., [RefSeq, PubMed]; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation., [UniProtKB]; DOK1 and DOK2 regulate CD8 T cell signaling and memory formation without affecting tumor cell killing. Publication Status: Online-Only, [RefSeq, PubMed]; Findings demonstrate that Dok-3 and Dok-1/-2 play distinctive but cooperative roles in osteoclastogenesis and protect mice from osteopenia, providing physiological and pathophysiological insight into bone homeostasis., [RefSeq, PubMed]; Introduction to DOK2 and its potential role in cancer. Review article, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70272;Q99KL1", "ec_number_list": [], "go_molecular_function": "GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007265 Ras protein signal transduction;GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O70469-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88508-1", "uniprot_id": [ { "id": "DNM3A_MOUSE", "url": "https://www.uniprot.org/uniprot/O88508", "type": "external" } ], "mass": 101672.0, "length": 908, "protein_name": "DNA (cytosine-5)-methyltransferase 3A", "gene_name": "Dnmt3a", "organism": "Mouse", "refseq_name": "DNA (cytosine-5)-methyltransferase 3A isoform 1", "refseq_ac": [ { "id": "NP_001258682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258682", "type": "external" } ], "gene_names_uniprotkb": "Dnmt3a", "gene_names_refseq": "Dnmt3a; MmuIIIA", "protein_names_uniprotkb": "DNA (cytosine-5)-methyltransferase 3A; 2.1.1.-; 2.1.1.37; Cysteine methyltransferase DNMT3A; DNA MTase MmuIIIA; DNA methyltransferase MmuIIIA; Dnmt3a; M.MmuIIIA", "protein_names_refseq": "DNA (cytosine-5)-methyltransferase 3A isoform 1; DNA (cytosine-5)-methyltransferase 3A; DNA MTase MmuIIIA; DNA methyltransferase MmuIIIA; cysteine methyltransferase DNMT3A", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); Tatton-Brown-Rahman syndrome (Disease Ontology:DOID:0112339); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); prostatitis (Disease Ontology:DOID:14654); congenital heart disease (Disease Ontology:DOID:1682); endometriosis of uterus (Disease Ontology:DOID:288); endometriosis (Disease Ontology:DOID:289); middle cerebral artery infarction (Disease Ontology:DOID:3525); lung carcinoma (Disease Ontology:DOID:3905); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic myeloid leukemia (Disease Ontology:DOID:8552); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:13435); (R-MMU-212300); (R-MMU-3214858)", "pathway_count": 3, "publication_count": 25, "publication_id_list": "10555141;11350943;11399089;11919202;12138111;12616525;14752048;15215868;15456878;15671018;16357870;16472822;16567415;17713477;18823905;19798101;20547484;21183079;21481189;21750661;24129315;30478443;32674113;34428180;9662389", "class_list": "", "function": "Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:10555141, PubMed:11399089, PubMed:11919202, PubMed:16567415, PubMed:17713477, PubMed:9662389). DNA methylation is coordinated with methylation of histones (PubMed:10555141, PubMed:11399089, PubMed:11919202, PubMed:16567415, PubMed:17713477, PubMed:9662389). It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:10555141, PubMed:11399089, PubMed:11919202, PubMed:16567415, PubMed:17713477, PubMed:9662389). May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (PubMed:18823905). Plays a role in paternal and maternal imprinting (PubMed:15215868). Required for methylation of most imprinted loci in germ cells (PubMed:15215868). Acts as a transcriptional corepressor for ZBTB18 (PubMed:11350943). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (PubMed:20547484). Can actively repress transcription through the recruitment of HDAC activity (PubMed:11350943). Also has weak auto-methylation activity on Cys-706 in absence of DNA (PubMed:21481189)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; These findings suggest that Dnmt3a and Dnmt3a2 may have distinct DNA targets and different functions in development., [RefSeq, PubMed]; This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene causes developmental defects in multiple different organ systems. There is a pseudogene for this gene located on chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 22, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZK8;Q3UH24;Q8CJ60;Q922J0;Q9CSE1", "ec_number_list": [ { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.37", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.1.1.356", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.356", "type": "external" } ], "go_molecular_function": "GO:0003886 DNA (cytosine-5-)-methyltransferase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000775 chromosome, centromeric region;GO:0016363 nuclear matrix", "go_biological_process": "GO:0043045 epigenetic programming of gene expression;GO:1900039 positive regulation of cellular response to hypoxia;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "O88508-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28563-1", "uniprot_id": [ { "id": "DUS1_MOUSE", "url": "https://www.uniprot.org/uniprot/P28563", "type": "external" } ], "mass": 39370.0, "length": 367, "protein_name": "Dual specificity protein phosphatase 1", "gene_name": "Dusp1", "organism": "Mouse", "refseq_name": "dual specificity protein phosphatase 1", "refseq_ac": [ { "id": "NP_038670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038670", "type": "external" } ], "gene_names_uniprotkb": "Dusp1; 3ch134; Mkp1; Ptpn10; Ptpn16", "gene_names_refseq": "3CH134; Dusp1; MKP1; Ptpn16; erp; mkp-1", "protein_names_uniprotkb": "Dual specificity protein phosphatase 1; 3.1.3.16; 3.1.3.48; MAP kinase phosphatase 1; MKP-1; Mitogen-activated protein kinase phosphatase 1; Protein-tyrosine phosphatase 3CH134; Protein-tyrosine phosphatase ERP", "protein_names_refseq": "MAP kinase phosphatase 1; dual specificity protein phosphatase 1; mitogen-activated protein kinase phosphatase-1; protein tyrosine phosphatase, non-receptor type 16; protein-tyrosine phosphatase 3CH134; protein-tyrosine phosphatase ERP", "tax_id": 10090, "disease": "diabetic encephalopathy (Disease Ontology:DOID:0050850); prostate cancer (Disease Ontology:DOID:10283); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); Huntington's disease (Disease Ontology:DOID:12858); major depressive disorder (Disease Ontology:DOID:1470); breast cancer (Disease Ontology:DOID:1612); squamous cell carcinoma (Disease Ontology:DOID:1749); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian carcinoma (Disease Ontology:DOID:4001); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); pancreatitis (Disease Ontology:DOID:4989); psoriasis (Disease Ontology:DOID:8893); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:19252); (R-MMU-112409); (R-MMU-5675221)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10617468;1741163;20484733;20727407;20935641;21750661;25428506;25428507;25605945;27802388;30084848;30779550;31599954;34428180;37828378;38531054;39067836;8221888;8355678", "class_list": "", "function": "CCR7/DUSP1 signaling Axis mediates iCAF to regulates head and neck squamous cell carcinoma growth. Erratum:[Cell Signal. 2025 Jul;131:111768. doi: 10.1016/j.cellsig.2025.111768. PMID: 40185659], [RefSeq, PubMed]; Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle., [UniProtKB, PubMed]; Enhanced MAPK signaling induced by CSF3R mutants confers dependence to DUSP1 for leukemic transformation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0019838 growth factor binding;GO:0051019 mitogen-activated protein kinase binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0035335 peptidyl-tyrosine dephosphorylation;GO:1990869 cellular response to chemokine;GO:0090027 negative regulation of monocyte chemotaxis;GO:0007162 negative regulation of cell adhesion;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P28563-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37913-1", "uniprot_id": [ { "id": "DNLI1_MOUSE", "url": "https://www.uniprot.org/uniprot/P37913", "type": "external" } ], "mass": 102290.0, "length": 916, "protein_name": "DNA ligase 1", "gene_name": "Lig1", "organism": "Mouse", "refseq_name": "DNA ligase 1", "refseq_ac": [ { "id": "NP_034845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034845", "type": "external" } ], "gene_names_uniprotkb": "Lig1; Lig-1", "gene_names_refseq": "Lig1; LigI", "protein_names_uniprotkb": "DNA ligase 1; 6.5.1.1; DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1", "protein_names_refseq": "DNA ligase 1; DNA ligase I; polydeoxyribonucleotide synthase [ATP] 1", "tax_id": 10090, "disease": "immunodeficiency 96 (Disease Ontology:DOID:0061066); cancer (Disease Ontology:DOID:162); primary immunodeficiency disease (Disease Ontology:DOID:612); inherited metabolic disorder (Disease Ontology:DOID:655); epilepsy with generalized tonic-clonic seizures (Disease Ontology:DOID:7725)", "pathway": " (mmu:16881); (R-MMU-110362); (R-MMU-174414); (R-MMU-5358565); (R-MMU-5358606); (R-MMU-5651801); (R-MMU-5685938); (R-MMU-6782210); (R-MMU-69183)", "pathway_count": 9, "publication_count": 17, "publication_id_list": "17242355;19131326;19144319;21183079;21750661;22645316;23806337;24788674;25153642;28528544;31219806;34428180;36210013;36928068;39627609;7642116;8039710", "class_list": "", "function": "DNA ligase that seals nicks in double-stranded during DNA repair. Also involved in DNA replication and DNA recombination., [UniProtKB, UniProtKB]; Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0003909 DNA ligase activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003910 DNA ligase (ATP) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006273 lagging strand elongation;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P37913-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40764-1", "uniprot_id": [ { "id": "DLX2_MOUSE", "url": "https://www.uniprot.org/uniprot/P40764", "type": "external" } ], "mass": 34746.0, "length": 332, "protein_name": "Homeobox protein DLX-2", "gene_name": "Dlx2", "organism": "Mouse", "refseq_name": "homeobox protein DLX-2", "refseq_ac": [ { "id": "NP_034184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034184", "type": "external" } ], "gene_names_uniprotkb": "Dlx2; Tes-1; Tes1", "gene_names_refseq": "DII A; Dlx-2; Dlx2; Tes-1", "protein_names_uniprotkb": "Homeobox protein DLX-2; Homeobox protein TES-1", "protein_names_refseq": "homeobox protein DLX-2; homeobox protein TES-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:13392)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "1632970;1678612;1687503;21875655;23371388;25428506;7893603;8098616;8812481", "class_list": "", "function": "Acts as a transcriptional activator (PubMed:21875655). Activates transcription of CGA/alpha-GSU, via binding to the downstream activin regulatory element (DARE) in the gene promoter (PubMed:23371388). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (PubMed:21875655). Likely to play a regulatory role in the development of the ventral forebrain (PubMed:1678612). May play a role in craniofacial patterning and morphogenesis (PubMed:1678612)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0003727 single-stranded RNA binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021879 forebrain neuron differentiation;GO:0046533 negative regulation of photoreceptor cell differentiation;GO:0021544 subpallium development;GO:0021893 cerebral cortex GABAergic interneuron fate commitment;GO:0048755 branching morphogenesis of a nerve", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P40764-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TDN0-1", "uniprot_id": [ { "id": "DISP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TDN0", "type": "external" } ], "mass": 170130.0, "length": 1521, "protein_name": "Protein dispatched homolog 1", "gene_name": "Disp1", "organism": "Mouse", "refseq_name": "protein dispatched homolog 1", "refseq_ac": [ { "id": "NP_001265147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265147", "type": "external" } ], "gene_names_uniprotkb": "Disp1; Dispa; Disp; Icbins; Icb", "gene_names_refseq": "1190008H24Rik; Disp1; DispA", "protein_names_uniprotkb": "Protein dispatched homolog 1; Mdispa", "protein_names_refseq": "dispatched A; dispatched homolog 1; mdispa; protein dispatched homolog 1; twelve-pass transmembrane protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:68897)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;12372258;12372301;12421714;19184110;21750661;22902404;29359685;31219806;33570491;34428180;34707294", "class_list": "", "function": "Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex. Publication Status: Online-Only, [RefSeq, PubMed]; Disp is required for the movement of Hh protein from its sites of synthesis in mice, [RefSeq, PubMed]; Dispatched uses Na(+) flux to power release of lipid-modified Hedgehog., [RefSeq, PubMed]; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (PubMed:22902404)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Shh signaling is required within the notochord to maintain Shh expression and to prevent notochord degeneration. Disp1, unlike Smo, is not required for this juxtacrine signaling by Shh., [RefSeq, PubMed]; The results showed that a protein called Furin activates Dispatched by splitting it at a specific point. When the break-point on Dispatch was genetically modified, Furin could no longer cleave the protein. As a consequence, Dispatched did not reach the correct location within cells to help Hedgehog move away from signal-releasing cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q3UUL8;Q80ZZ8;Q8CGS3;Q8CIP6;Q8CIQ9;Q9CT62", "ec_number_list": [], "go_molecular_function": "GO:0140104 molecular carrier activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0015833 peptide transport;GO:0007368 determination of left/right symmetry;GO:0009953 dorsal/ventral pattern formation;GO:0007224 smoothened signaling pathway;GO:0007225 patched ligand maturation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q3TDN0-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PR73-1", "uniprot_id": [ { "id": "DIRA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5PR73", "type": "external" } ], "mass": 22498.0, "length": 199, "protein_name": "GTP-binding protein Di-Ras2", "gene_name": "Diras2", "organism": "Mouse", "refseq_name": "GTP-binding protein Di-Ras2", "refseq_ac": [ { "id": "NP_001019645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019645", "type": "external" } ], "gene_names_uniprotkb": "Diras2", "gene_names_refseq": "2900052J15Rik; Diras2", "protein_names_uniprotkb": "GTP-binding protein Di-Ras2; 3.6.5.-; Distinct subgroup of the Ras family member 2", "protein_names_refseq": "GTP-binding protein Di-Ras2; distinct subgroup of the Ras family member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68203)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;29488099;30623719;33300544", "class_list": "", "function": "Displays low GTPase activity and exists predominantly in the GTP-bound form., [UniProtKB, UniProtKB]; Knockdown of the ADHD Candidate Gene Diras2 in Murine Hippocampal Primary Cells., [RefSeq, PubMed]; Our findings support the idea of DIRAS2 as a candidate gene for attention-deficit/hyperactivity disorder, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5PR73-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFP6-1", "uniprot_id": [ { "id": "DJC27_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CFP6", "type": "external" } ], "mass": 30831.0, "length": 273, "protein_name": "DnaJ homolog subfamily C member 27", "gene_name": "Dnajc27", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily C member 27", "refseq_ac": [ { "id": "NP_694722", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694722", "type": "external" } ], "gene_names_uniprotkb": "Dnajc27; Rabj; Rbj", "gene_names_refseq": "C330021A05Rik; Dnajc27; Rabj; Rbj", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 27; Rab and DnaJ domain-containing protein", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 27; Rab-related GTP-binding protein; dnaJ homolog subfamily C member 27; rab and DnaJ domain containing; rab and DnaJ domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:217378)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14980719;24746703", "class_list": "", "function": "GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling., [UniProtKB, PubMed]; These data suggest that RBJ may be an oncogenic Ras-related small GTPase mediating nuclear accumulation of active MEK1/MEK2 in tumor progression. Erratum:[Cancer Cell. 2021 Mar 8;39(3):438-440. doi: 10.1016/j.ccell.2021.02.010. PMID: 33689704], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BX00;Q923I0", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CFP6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4V2-1", "uniprot_id": [ { "id": "DUS15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R4V2", "type": "external" } ], "mass": 26186.0, "length": 235, "protein_name": "Dual specificity protein phosphatase 15", "gene_name": "Dusp15", "organism": "Mouse", "refseq_name": "dual specificity protein phosphatase 15 isoform 1", "refseq_ac": [ { "id": "NP_001152848", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152848", "type": "external" } ], "gene_names_uniprotkb": "Dusp15", "gene_names_refseq": "Dusp15; LMW-DSP10; T-DSP10", "protein_names_uniprotkb": "Dual specificity protein phosphatase 15; 3.1.3.16; 3.1.3.48; Dual specificity protein phosphatase T-DSP10", "protein_names_refseq": "dual specificity protein phosphatase 15 isoform 1; dual specificity protein phosphatase 15; dual specificity protein phosphatase T-DSP10", "tax_id": 10090, "disease": "", "pathway": " (mmu:252864)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11432789;11812828;15138252;21750661;22792334;27532821;27891578;36730342;39261048", "class_list": "", "function": "DUSP15 expression is reduced in the hippocampus of Myrf knock-out mice but attention and object recognition memory remain intact. Publication Status: Online-Only, [RefSeq, PubMed]; Dusp15 is necessary for full activation of Erk 1/2 phosphorylation in Schwann cells., [RefSeq, PubMed]; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (By similarity)., [UniProtKB, UniProtKB]; May play a role in the regulation of oligodendrocyte differentiation (PubMed:22792334). May play a role in the regulation of myelin formation (By similarity). Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (By similarity)., [UniProtKB, UniProtKB, PubMed]; The Atypical Dual Specificity Phosphatase DUSP15 Regulates Jak1-Mediated STAT3 Activation., [RefSeq, PubMed]; VHY is a new member of a subgroup of myristoylated VH1-like small dual specificity phosphatases, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2APC1;Q14AH2", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0016791 phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0016311 dephosphorylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007165 signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0048713 regulation of oligodendrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8R4V2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WZ8-1", "uniprot_id": [ { "id": "DTBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WZ8", "type": "external" } ], "mass": 39651.0, "length": 352, "protein_name": "Dysbindin", "gene_name": "Dtnbp1", "organism": "Mouse", "refseq_name": "dysbindin", "refseq_ac": [ { "id": "NP_080048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080048", "type": "external" } ], "gene_names_uniprotkb": "Dtnbp1; Bloc1s8; Sdy", "gene_names_refseq": "5430437B18Rik; Bloc1s8; Dtnbp1; dysbindin; sdy", "protein_names_uniprotkb": "Dysbindin; BLOC-1 subunit 8; Biogenesis of lysosome-related organelles complex 1 subunit 8; Dysbindin-1; Dystrobrevin-binding protein 1; HPS7 protein homolog; Hermansky-Pudlak syndrome 7 protein homolog", "protein_names_refseq": "BLOC-1 subunit 8; HPS7 protein homolog; biogenesis of lysosome-related organelles complex 1 subunit 8; dysbindin-1; dysbindin; hermansky-Pudlak syndrome 7 protein homolog; sandy", "tax_id": 10090, "disease": "Hermansky-Pudlak syndrome 7 (Disease Ontology:DOID:0060545); platelet storage pool deficiency (Disease Ontology:DOID:2223); temporal lobe epilepsy (Disease Ontology:DOID:3328); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753); schizophrenia (Disease Ontology:DOID:5419); metal metabolism disorder (Disease Ontology:DOID:896)", "pathway": " (mmu:94245); (R-MMU-432722)", "pathway_count": 2, "publication_count": 36, "publication_id_list": "11316798;12923531;14688250;15345706;16448387;16760431;16837549;16980328;17577571;18504299;18555792;18945333;18984010;19094965;19142223;19220483;1936982;19428785;19546860;19887632;20045719;20302821;20921223;20956979;21183079;21750661;21998198;22554196;30084848;30779550;33589740;34428180;35820727;35821415;36168739;38956130", "class_list": "", "function": "Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Dysbindin-1 regulates mitochondrial fission and gamma oscillations., [RefSeq, PubMed]; Dysbindin-1A modulation of astrocytic dopamine and basal ganglia dependent behaviors relevant to schizophrenia., [RefSeq, PubMed]; Exposure to Circadian Disruption During Adolescence Interacts With a Genetic Risk Factor to Modify Schizophrenia-relevant Behaviors in a Sex-dependent Manner., [RefSeq, PubMed]; Loss of dysbindin-1 in excitatory neurons in mice impacts NMDAR-dependent behaviors, neuronal morphology and synaptic transmission in the ventral hippocampus. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TWK1;Q6WXQ1;Q80ZN4;Q9CY43", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0007613 memory;GO:0010628 positive regulation of gene expression;GO:0031175 neuron projection development;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q91WZ8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZK4-1", "uniprot_id": [ { "id": "DMBX1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZK4", "type": "external" } ], "mass": 41115.0, "length": 381, "protein_name": "Diencephalon/mesencephalon homeobox protein 1", "gene_name": "Dmbx1", "organism": "Mouse", "refseq_name": "diencephalon/mesencephalon homeobox protein 1 isoform b", "refseq_ac": [ { "id": "NP_001020738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020738", "type": "external" } ], "gene_names_uniprotkb": "Dmbx1; Cdmx; Mbx; Otx3; PaxB", "gene_names_refseq": "Atx; Cdmx; Dmbx1; Mbx; Otx3", "protein_names_uniprotkb": "Diencephalon/mesencephalon homeobox protein 1; Diencephalon/mesencephalon-expressed brain homeobox gene 1 protein; Orthodenticle homolog 3; Paired-like homeobox protein DMBX1; Paired-type homeobox Atx", "protein_names_refseq": "diencephalon/mesencephalon homeobox protein 1 isoform b; diencephalon/mesencephalon homeobox protein 1; diencephalon/mesencephalon-expressed brain homeobox gene 1 protein; homeobox gene Atx; orthodenticle homolog 3; paired-like homeobox protein DMBX1; paired-type homeobox Atx", "tax_id": 10090, "disease": "", "pathway": " (mmu:140477)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11744391;11914943;12055180;12111214;12175514;12175515;15314164;15890343;32240164", "class_list": "", "function": "ATX genetic deletion from CD11b+ cells attenuated the severity of experimental autoimmune encephalomyelitis (EAE), thus proposing a pathogenic role for the ATX/LPA axis in neuroinflammatory disorders. Publication Status: Online-Only, [RefSeq, PubMed]; Dmbx1, a novel evolutionarily conserved paired-like homeobox gene is expressed in the brain of mouse embryos. Linkage analysis mapped mouse Dmbx1 to the mid-portion of chromosome 4., [RefSeq, PubMed]; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development, neonatal survival, postnatal growth, and nursing ability., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Provides a useful molecular marker for early mouse midbrain development and may play a critical role in brain development, [RefSeq, PubMed]; Results suggest that Otx3 is a novel member of the Otx family and may be involved in the development of the central nervous system, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1ASG1;Q8CH43;Q8K4U6;Q8VHG8;Q91ZK3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008344 adult locomotory behavior;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91ZK4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZ59-1", "uniprot_id": [ { "id": "DMRT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZ59", "type": "external" } ], "mass": 39444.0, "length": 374, "protein_name": "Doublesex- and mab-3-related transcription factor 1", "gene_name": "Dmrt1", "organism": "Mouse", "refseq_name": "doublesex- and mab-3-related transcription factor 1", "refseq_ac": [ { "id": "NP_056641", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056641", "type": "external" } ], "gene_names_uniprotkb": "Dmrt1", "gene_names_refseq": "Dmrt1", "protein_names_uniprotkb": "Doublesex- and mab-3-related transcription factor 1", "protein_names_refseq": "doublesex- and mab-3-related transcription factor 1", "tax_id": 10090, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:50796)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10545231;10604464;10640721;11040213;17141192;17540358;20007774;20616082;20951351;21183079;21621532;21775990;36852467;39432160", "class_list": "", "function": "Diversity of transactivation regions of DMRT1 in vertebrates. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q19AV2;Q2TDQ9;Q6Y951;Q6Y953;Q9QZ37;Q9QZA4", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:2000020 positive regulation of male gonad development;GO:0003006 developmental process involved in reproduction;GO:0046661 male sex differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9QZ59-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CJF7-1", "uniprot_id": [ { "id": "ELYS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CJF7", "type": "external" } ], "mass": 247646.0, "length": 2243, "protein_name": "Protein ELYS", "gene_name": "Ahctf1", "organism": "Mouse", "refseq_name": "protein ELYS", "refseq_ac": [ { "id": "NP_080651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080651", "type": "external" } ], "gene_names_uniprotkb": "Ahctf1; Elys", "gene_names_refseq": "6230412P20Rik; Ahctf1; Elys", "protein_names_uniprotkb": "Protein ELYS; Embryonic large molecule derived from yolk sac; Protein MEL-28; Putative AT-hook-containing transcription factor 1", "protein_names_refseq": "embryonic large molecule derived from yolk sac; protein ELYS; putative AT-hook-containing transcription factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:226747); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9615933); (R-MMU-9648025)", "pathway_count": 9, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;11952839;12745078;15507119;17242355;18299400;19144319;19224205;20173027;21183079;21315719;21750661;21952136;22872234;23499022;23806337;25428506;25605945;26495903;28011936;30084848;30779550;34203471;34428180;35820727;36852467;37828378", "class_list": "", "function": "Genomic organization and characterization of the ELYS gene., [RefSeq, PubMed]; In mice, Elys maintains genome stability in intestinal epithelial progenitor cells, independent of its role in NPC assembly in zebrafish., [RefSeq, PubMed]; Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis (By similarity). Has also been proposed to function as a transcription factor which may play a specific role in hematopoietic tissues (PubMed:11952839)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 29, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B2RRC8;Q8BVJ5;Q8VD55", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006913 nucleocytoplasmic transport;GO:0015031 protein transport;GO:0051301 cell division;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q8CJF7-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YP0-1", "uniprot_id": [ { "id": "L2HDH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YP0", "type": "external" } ], "mass": 50899.0, "length": 464, "protein_name": "L-2-hydroxyglutarate dehydrogenase, mitochondrial", "gene_name": "L2hgdh", "organism": "Mouse", "refseq_name": "L-2-hydroxyglutarate dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_663418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663418", "type": "external" } ], "gene_names_uniprotkb": "L2hgdh", "gene_names_refseq": "L2hgdh", "protein_names_uniprotkb": "L-2-hydroxyglutarate dehydrogenase, mitochondrial; 1.1.99.2; Duranin", "protein_names_refseq": "L-2-hydroxyglutarate dehydrogenase, mitochondrial precursor; L-2-hydroxyglutarate dehydrogenase, mitochondrial; duranin", "tax_id": 10090, "disease": "2-hydroxyglutaric aciduria (Disease Ontology:DOID:0050573); L-2-hydroxyglutaric aciduria (Disease Ontology:DOID:0050574); cerebellar ataxia (Disease Ontology:DOID:0050753); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:217666); (R-MMU-880009)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "21750661;23576753;25763823;28137912;32928875;34428180;35820727;36288343;37507081", "class_list": "", "function": "Catalyzes the oxidation of L-2-hydroxyglutarate to 2-oxoglutarate (alpha-ketoglutarate)., [UniProtKB, UniProtKB]; Data describe a mouse model of L-2-hydroxyglutaric aciduria where mouse with l2hgdh gene deficiency accumulates toxic levels of L-2-hydroxyglutarate mostly in brain and testis and shows significant brain spongiosis and learning deficit. Publication Status: Online-Only, [RefSeq, PubMed]; L2hgdh mutation leads to l-2-hydroxyglutarate accumulation, leukoencephalopathy, and neurodegeneration in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TH61;Q3U7Z0;Q3ULY6", "ec_number_list": [ { "id": "1.1.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.99.2", "type": "external" } ], "go_molecular_function": "GO:0047545 (S)-2-hydroxyglutarate dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "GO:0044281 small molecule metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q91YP0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11627-1", "uniprot_id": [ { "id": "L1CAM_MOUSE", "url": "https://www.uniprot.org/uniprot/P11627", "type": "external" } ], "mass": 140969.0, "length": 1260, "protein_name": "Neural cell adhesion molecule L1", "gene_name": "L1cam", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "L1cam; Caml1", "gene_names_refseq": "", "protein_names_uniprotkb": "Neural cell adhesion molecule L1; N-CAM-L1; NCAM-L1", "protein_names_refseq": "", "tax_id": 10090, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); MASA syndrome (Disease Ontology:DOID:0060246); Alzheimer's disease (Disease Ontology:DOID:10652); hydrocephalus (Disease Ontology:DOID:10908); hypothyroidism (Disease Ontology:DOID:1459); depressive disorder (Disease Ontology:DOID:1596); pancreatic cancer (Disease Ontology:DOID:1793); epilepsy (Disease Ontology:DOID:1826); anxiety disorder (Disease Ontology:DOID:2030); glioblastoma (Disease Ontology:DOID:3068); bipolar disorder (Disease Ontology:DOID:3312); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); uterine cancer (Disease Ontology:DOID:363); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ovarian carcinoma (Disease Ontology:DOID:4001); schizophrenia (Disease Ontology:DOID:5419); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:16728); (R-MMU-210991); (R-MMU-373760); (R-MMU-437239); (R-MMU-445095); (R-MMU-445144)", "pathway_count": 6, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;12514225;12558975;19349973;21183079;21750661;25605945;26495903;26740625;28011936;30084848;30899004;32152506;33300544;3412448;37828378", "class_list": "glycogene", "function": "Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 18, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 18, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 18, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 18, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 70, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 59, "disease_count": 17, "glyco_site_count": 21, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0030165 PDZ domain binding;GO:0033691 sialic acid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0044860 protein localization to plasma membrane raft;GO:0034109 homotypic cell-cell adhesion;GO:0098749 cerebellar neuron development;GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 9.5, "record_id": "P11627-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000010001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21619-1", "uniprot_id": [ { "id": "LMNB2_MOUSE", "url": "https://www.uniprot.org/uniprot/P21619", "type": "external" } ], "mass": 67318.0, "length": 596, "protein_name": "Lamin-B2", "gene_name": "Lmnb2", "organism": "Mouse", "refseq_name": "lamin-B2 isoform 2", "refseq_ac": [ { "id": "NP_001334069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334069", "type": "external" } ], "gene_names_uniprotkb": "Lmnb2", "gene_names_refseq": "Lmnb2", "protein_names_uniprotkb": "Lamin-B2", "protein_names_refseq": "lamin B3; lamin-B2 isoform 2", "tax_id": 10090, "disease": "congenital muscular dystrophy (Disease Ontology:DOID:0050557); autosomal dominant primary microcephaly 27 (Disease Ontology:DOID:0051038); familial partial lipodystrophy type 2 (Disease Ontology:DOID:0070202); autosomal dominant Emery-Dreifuss muscular dystrophy 2 (Disease Ontology:DOID:0070247); autosomal recessive Emery-Dreifuss muscular dystrophy 3 (Disease Ontology:DOID:0070248); partial lipodystrophy (Disease Ontology:DOID:0080299); dilated cardiomyopathy 1A (Disease Ontology:DOID:0110425); congenital muscular dystrophy due to LMNA mutation (Disease Ontology:DOID:0110640); progressive myoclonus epilepsy 9 (Disease Ontology:DOID:0111450); Emery-Dreifuss muscular dystrophy (Disease Ontology:DOID:11726); progeria (Disease Ontology:DOID:3911); myopathy (Disease Ontology:DOID:423); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:16907)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "16106909;16452087;18230648;1939065;2102682;21750661;2311764;24129315;25482116;28241138;34428180;8094052", "class_list": "", "function": "Data show that lamins B1 and B2 have unique functions and that increased production of one B-type lamin cannot compensate for the loss of the other., [RefSeq, PubMed]; Evidence suggests that germ line-specific lamin B3 reduces the stability of the nuclear periphery due to its shortened rod domain., [RefSeq, PubMed]; Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28241138). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28241138). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28241138)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; This gene encodes a protein component of the nuclear lamina, which provides a structural framework for the nuclear envelope. Defects in this gene were found to cause abnormalities in the shape of neurons. This locus represents one of two B-type lamin genes that may be partially, but not entirely, functionally redundant in neuronal development. Loss of both B-type lamin genes in keratinocytes results in ichthyosis and a skin barrier defect leading to dehydration. Alternative transcriptional initiation and splicing results in multiple transcript variants and protein isoforms, including an isoform with a shorter N-terminal rod domain that may function in nuclear envelope remodeling during spermatogenesis. A related pseudogene is found on chromosome 5. [provided by RefSeq, Sep 2017]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P48680;Q8CGB1", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0031965 nuclear membrane;GO:0034399 nuclear periphery;GO:0005652 nuclear lamina", "go_biological_process": "GO:0090435 protein localization to nuclear envelope;GO:0006998 nuclear envelope organization;GO:0031507 heterochromatin formation;GO:0007097 nuclear migration;GO:0051664 nuclear pore localization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P21619-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K215-1", "uniprot_id": [ { "id": "LYRM4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K215", "type": "external" } ], "mass": 10855.0, "length": 91, "protein_name": "LYR motif-containing protein 4", "gene_name": "Lyrm4", "organism": "Mouse", "refseq_name": "LYR motif-containing protein 4", "refseq_ac": [ { "id": "NP_958746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958746", "type": "external" } ], "gene_names_uniprotkb": "Lyrm4; Isd11", "gene_names_refseq": "Gm903; Lyrm4", "protein_names_uniprotkb": "LYR motif-containing protein 4", "protein_names_refseq": "LYR motif-containing protein 4", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 19 (Disease Ontology:DOID:0111476)", "pathway": " (mmu:380840); (R-MMU-1362409); (R-MMU-9854311); (R-MMU-9865881)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "16075062;21298097;23806337;25597503;34428180", "class_list": "", "function": "Stabilizing factor, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with NDUFAB1, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). May also participates in the iron-sulfur protein biogenesis in the cytoplasm through its interaction with the cytoplasmic form of NFS1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042803 protein homodimerization activity;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0016604 nuclear body;GO:1990221 L-cysteine desulfurase complex;GO:0099128 mitochondrial [2Fe-2S] assembly complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0044571 [2Fe-2S] cluster assembly;GO:0044572 [4Fe-4S] cluster assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K215-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VH1-1", "uniprot_id": [ { "id": "PAQR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VH1", "type": "external" } ], "mass": 42366.0, "length": 375, "protein_name": "Adiponectin receptor protein 1", "gene_name": "Adipor1", "organism": "Mouse", "refseq_name": "adiponectin receptor protein 1", "refseq_ac": [ { "id": "NP_001292998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292998", "type": "external" } ], "gene_names_uniprotkb": "Adipor1; Parq1", "gene_names_refseq": "2810031L11Rik; ACDCR1; Adipor1; CGI-45; Paqr1", "protein_names_uniprotkb": "Adiponectin receptor protein 1; Progestin and adipoQ receptor family member 1; Progestin and adipoQ receptor family member I", "protein_names_refseq": "adiponectin receptor protein 1; progestin and adipoQ receptor family member 1; progestin and adipoQ receptor family member I", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612); hyperinsulinism (Disease Ontology:DOID:2018); prostate adenocarcinoma (Disease Ontology:DOID:2526); hyperglycemia (Disease Ontology:DOID:4195); macular degeneration (Disease Ontology:DOID:4448); end stage renal disease (Disease Ontology:DOID:783); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:72674); (R-MMU-163680)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "12802337;15123605;15358228;15454091;17268472;17327425;19661063;24742672;25428506;30084848;34428180", "class_list": "", "function": "A link between adiponectin and bone homeostasis by demonstrating transcription, translation, and secretion of adiponectin, as well as expression of its receptors, AdipoR1 and AdipoR2, in bone-forming cells, [RefSeq, PubMed]; Adiponectin receptor expression is regulated by insulin and Foxo1, [RefSeq, PubMed]; Cloning of cDNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) by expression cloning [AdipoR1 & AdipoR2] Erratum:[Nature. 2004 Oct 28;431(7012):1123], [RefSeq, PubMed]; Expressed in islets, muscle and liver; expression in mouse islets related to dietary fat., [RefSeq, PubMed]; Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:17268472, PubMed:17327425, PubMed:24742672). Required for normal glucose and fat homeostasis and for maintaining a normal body weight (PubMed:17327425, PubMed:24742672). ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis (PubMed:12802337, PubMed:17268472, PubMed:17327425, PubMed:24742672). Has high affinity for globular adiponectin and low affinity for full-length adiponectin (PubMed:12802337)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes a receptor for the fat-derived hormone adiponectin. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. Homozygous knockout mice for this gene exhibit elevated plasma glucose and insulin levels as well as impaired glucose tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZA0", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0055100 adiponectin binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0010633 negative regulation of epithelial cell migration;GO:0010906 regulation of glucose metabolic process;GO:0019216 regulation of lipid metabolic process;GO:0019395 fatty acid oxidation;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q91VH1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ69-1", "uniprot_id": [ { "id": "QCR8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ69", "type": "external" } ], "mass": 9768.0, "length": 82, "protein_name": "Cytochrome b-c1 complex subunit 8", "gene_name": "Uqcrq", "organism": "Mouse", "refseq_name": "cytochrome b-c1 complex subunit 8", "refseq_ac": [ { "id": "NP_001313543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001313543", "type": "external" } ], "gene_names_uniprotkb": "Uqcrq", "gene_names_refseq": "1100001F06Rik; 1500040F11Rik; 5830407L17Rik; 9.5kDa; QP-C; Qpc; Uqcrb; Uqcrq; c1502", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 8; Complex III subunit 8; Complex III subunit VIII; Ubiquinol-cytochrome c reductase complex 9.5 kDa protein; Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C", "protein_names_refseq": "complex III subunit 8; complex III subunit VIII; complex III subunit VII; cytochrome b-c1 complex subunit 8; low molecular mass ubiquinone-binding protein (Qpc-pending); ubiquinol-cytochrome c reductase binding protein; ubiquinol-cytochrome c reductase complex 9.5 kDa protein; ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C", "tax_id": 10090, "disease": "mitochondrial complex III deficiency nuclear type 4 (Disease Ontology:DOID:0080113)", "pathway": " (mmu:22272); (R-MMU-611105); (R-MMU-9837999); (R-MMU-9865881)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "19026783;21750661;23576753;23806337;30084848;32161263;33300544;34428180;34616041;36288343;37453647;38575788", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0021766 hippocampus development;GO:0021680 cerebellar Purkinje cell layer development;GO:0021860 pyramidal neuron development;GO:0021854 hypothalamus development;GO:0021539 subthalamus development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9CQ69-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P7W5-1", "uniprot_id": [ { "id": "SEN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P7W5", "type": "external" } ], "mass": 52214.0, "length": 460, "protein_name": "tRNA-splicing endonuclease subunit Sen2", "gene_name": "Tsen2", "organism": "Mouse", "refseq_name": "tRNA-splicing endonuclease subunit Sen2 isoform 1", "refseq_ac": [ { "id": "NP_950198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950198", "type": "external" } ], "gene_names_uniprotkb": "Tsen2; Sen2", "gene_names_refseq": "Tsen2", "protein_names_uniprotkb": "tRNA-splicing endonuclease subunit Sen2; 4.6.1.16; tRNA-intron endonuclease Sen2", "protein_names_refseq": "tRNA splicing endonuclease 2 homolog; tRNA-intron endonuclease Sen2; tRNA-splicing endonuclease subunit Sen2 isoform 1; tRNA-splicing endonuclease subunit Sen2", "tax_id": 10090, "disease": "pontocerebellar hypoplasia type 2B (Disease Ontology:DOID:0060268)", "pathway": " (mmu:381802)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15345747;21750661;31219806;34428180", "class_list": "", "function": "Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UYG6", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0000213 tRNA-intron lyase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0006397 mRNA processing;GO:0008033 tRNA processing;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation;GO:0000379 tRNA-type intron splice site recognition and cleavage", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6P7W5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BP27-1", "uniprot_id": [ { "id": "SFR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BP27", "type": "external" } ], "mass": 35183.0, "length": 319, "protein_name": "Swi5-dependent recombination DNA repair protein 1 homolog", "gene_name": "Sfr1", "organism": "Mouse", "refseq_name": "swi5-dependent recombination DNA repair protein 1 homolog", "refseq_ac": [ { "id": "NP_080653", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080653", "type": "external" } ], "gene_names_uniprotkb": "Sfr1; Mei5; Meir5", "gene_names_refseq": "6330577E15Rik; Meir5; Sfr1", "protein_names_uniprotkb": "Swi5-dependent recombination DNA repair protein 1 homolog; Meiosis protein 5 homolog", "protein_names_refseq": "DNA repair protein Sfr1; meiosis protein 5 homolog; swi5-dependent recombination DNA repair protein 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67788)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15345747;17242355;19131326;20976249;21183079;22492707;27131790;30297419", "class_list": "", "function": "Biophysical evidence that the mouse Swi5-Sfr1 complex has a 1:1 stoichiometry., [RefSeq, PubMed]; Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (PubMed:20976249). Acts as a transcriptional modulator for ESR1., [UniProtKB, PubMed, UniProtKB]; Data show that Swi5-Sfr1 is a newly identified complex required for genomic integrity in mammalian cells with a specific role in the repair of DNA strand breaks. Publication Status: Online-Only, [RefSeq, PubMed]; Our results thus help establish the functional relevance of the trimeric RAD51-SWI5-SFR1 complex and provide insights into the mechanistic underpinnings of homology-directed DNA repair in mammalian cells., [RefSeq, PubMed]; Swi5-Sfr1 (S5S1) stimulates Rad51-mediated homologous recombination., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TH62;Q3TI03;Q3TJK0;Q3UIQ6;Q8R3W0;Q9CRT7;Q9D0D7;Q9D116;Q9D4W4", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005813 centrosome;GO:0032798 Swi5-Sfr1 complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0000724 double-strand break repair via homologous recombination;GO:0071391 cellular response to estrogen stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BP27-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99K85-1", "uniprot_id": [ { "id": "SERC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99K85", "type": "external" } ], "mass": 40473.0, "length": 370, "protein_name": "Phosphoserine aminotransferase", "gene_name": "Psat1", "organism": "Mouse", "refseq_name": "phosphoserine aminotransferase isoform 1", "refseq_ac": [ { "id": "NP_803155", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803155", "type": "external" } ], "gene_names_uniprotkb": "Psat1; Psat; Psa", "gene_names_refseq": "D8Ertd814e; EPIP; PSA; Psat1; Psat", "protein_names_uniprotkb": "Phosphoserine aminotransferase; 2.6.1.52; EPIP; Endometrial progesterone-induced protein; PSAT; Phosphohydroxythreonine aminotransferase", "protein_names_refseq": "endometrial progesterone-induced protein; phosphohydroxythreonine aminotransferase; phosphoserine aminotransferase isoform 1", "tax_id": 10090, "disease": "PSAT deficiency (Disease Ontology:DOID:0050723); Neu-Laxova syndrome 2 (Disease Ontology:DOID:0080075)", "pathway": " (mmu:107272); (R-MMU-977347)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21750661;23806337;25605945;30084848;30779550;34428180;38453480", "class_list": "", "function": "Involved in L-serine biosynthesis via the phosphorylated pathway, a three-step pathway converting the glycolytic intermediate 3-phospho-D-glycerate into L-serine. Catalyzes the second step, that is the pyridoxal 5'-phosphate-dependent transamination of 3-phosphohydroxypyruvate and L-glutamate to O-phosphoserine (OPS) and alpha-ketoglutarate. Acts as an inhibitor of ferroptosis in response to interferon-gamma (IFNG) by promoting GPX4 stability: following phosphorylation by CAMK2A, PSAT1 interacts with GPX4 and provides 2-oxoglutarate to EGLN3, leading to GPX4 hydroxylation and stability., [UniProtKB, UniProtKB]; Psat1-generated alpha-ketoglutarate and glutamine promote muscle stem cell activation and regeneration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.6.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.52", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0004648 O-phospho-L-serine:2-oxoglutarate aminotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006564 L-serine biosynthetic process;GO:0110076 negative regulation of ferroptosis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q99K85-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUH7-1", "uniprot_id": [ { "id": "SEM4G_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUH7", "type": "external" } ], "mass": 92378.0, "length": 837, "protein_name": "Semaphorin-4G", "gene_name": "Sema4g", "organism": "Mouse", "refseq_name": "semaphorin-4G precursor", "refseq_ac": [ { "id": "NP_036106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036106", "type": "external" } ], "gene_names_uniprotkb": "Sema4g", "gene_names_refseq": "Sema4g", "protein_names_uniprotkb": "Semaphorin-4G", "protein_names_refseq": "member of the semaphorin family; semaphorin-4G precursor; semaphorin-4G", "tax_id": 10090, "disease": "", "pathway": " (mmu:26456)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10495281;17242355;21122816;21183079;30899004;34428180;35820727", "class_list": "", "function": "Cell surface receptor for PLXNB2. May play a role in axon guidance., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0050919 negative chemotaxis;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9WUH7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9W0-1", "uniprot_id": [ { "id": "SPC1L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9W0", "type": "external" } ], "mass": 38164.0, "length": 342, "protein_name": "Speriolin-like protein", "gene_name": "Spatc1l", "organism": "Mouse", "refseq_name": "speriolin-like protein isoform 1", "refseq_ac": [ { "id": "NP_083937", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083937", "type": "external" } ], "gene_names_uniprotkb": "Spatc1l; 1700027D21Rik", "gene_names_refseq": "1700022B01Rik; 1700027D21Rik; Spatc1l", "protein_names_uniprotkb": "Speriolin-like protein; Spermatogenesis and centriole-associated protein 1-like protein", "protein_names_refseq": "speriolin-like protein isoform 1; speriolin-like protein; spermatogenesis and centriole-associated protein 1-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:76573)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;30026308;37828378", "class_list": "", "function": "These results implicate the SPATC1L-PKA complex in maintaining the stability of the sperm head-tail junction, thereby revealing a new molecular basis for sperm head-tail integrity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RW50", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0034237 protein kinase A regulatory subunit binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0120212 sperm head-tail coupling apparatus", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0007283 spermatogenesis;GO:0008154 actin polymerization or depolymerization;GO:2000481 positive regulation of cAMP-dependent protein kinase activity;GO:0141163 positive regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D9W0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70494-1", "uniprot_id": [ { "id": "SP3_MOUSE", "url": "https://www.uniprot.org/uniprot/O70494", "type": "external" } ], "mass": 82362.0, "length": 783, "protein_name": "Transcription factor Sp3", "gene_name": "Sp3", "organism": "Mouse", "refseq_name": "transcription factor Sp3 isoform 1", "refseq_ac": [ { "id": "NP_001018052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001018052", "type": "external" } ], "gene_names_uniprotkb": "Sp3", "gene_names_refseq": "D130027J01Rik; Sp3", "protein_names_uniprotkb": "Transcription factor Sp3", "protein_names_refseq": "transcription factor Sp3 isoform 1; transcription factor Sp3", "tax_id": 10090, "disease": "", "pathway": " (mmu:20687); (R-MMU-3232118)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "11472836;15554904;17670746;21183079;30084848;32848054;34428180;34678516;34887587;36759621;36762637;40997131;9628590", "class_list": "", "function": "Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice. Erratum:[Nat Commun. 2023 Apr 25;14(1):2371. doi: 10.1038/s41467-023-38092-6. PMID: 37185975] Publication Status: Online-Only, [RefSeq, PubMed]; Sp3 is an essential transcription factor for late bone development., [RefSeq, PubMed]; Sp3 is essential for normal lung morphogenesis and cell cycle progression during mouse embryonic development., [RefSeq, PubMed]; This gene product belongs to a family of Sp1 related transcription factors, which regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses transcription of numerous genes. Alternative splicing results in transcript variants encoding different isoforms, and one variant initiates translation from a non-AUG (AUA) codon. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2AQK9;Q68FF2;Q8CF64;Q8K378", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0017053 transcription repressor complex;GO:0016605 PML body", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0001779 natural killer cell differentiation;GO:0030851 granulocyte differentiation;GO:0043353 enucleate erythrocyte differentiation;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "O70494-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0X2-1", "uniprot_id": [ { "id": "SL9B1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0X2", "type": "external" } ], "mass": 61958.0, "length": 565, "protein_name": "Sodium/hydrogen exchanger 9B1", "gene_name": "Slc9b1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc9b1; Nha1; Nhedc1", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium/hydrogen exchanger 9B1; MtsNHE; NHE domain-containing protein 1; Na(+)/H(+) exchanger-like domain-containing protein 1; Sodium/hydrogen exchanger-like domain-containing protein 1; Solute carrier family 9 subfamily B member 1; Testis specific sodium-hydrogen exchanger", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-2672351)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19409551;20036903;21750661;27010853;31219806", "class_list": "", "function": "Sperm-specific Na(+)/H(+) exchanger involved in intracellular pH regulation of spermatozoa (PubMed:20036903). Involved in sperm motility and fertility (PubMed:19409551, PubMed:20036903, PubMed:27010853)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5AFL0;Q8C1I8;Q8R3N0;Q9CPR9;Q9D400", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0097228 sperm principal piece", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0007338 single fertilization;GO:0006814 sodium ion transport;GO:0051453 regulation of intracellular pH;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8C0X2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CH25-1", "uniprot_id": [ { "id": "SLTM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CH25", "type": "external" } ], "mass": 116919.0, "length": 1031, "protein_name": "SAFB-like transcription modulator", "gene_name": "Sltm", "organism": "Mouse", "refseq_name": "SAFB-like transcription modulator isoform a", "refseq_ac": [ { "id": "NP_079966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079966", "type": "external" } ], "gene_names_uniprotkb": "Sltm; Met", "gene_names_refseq": "5730455C01Rik; 5730555F13Rik; 9130215G10Rik; Met; Sltm", "protein_names_uniprotkb": "SAFB-like transcription modulator; Modulator of estrogen-induced transcription; SAF-like transcription modulator", "protein_names_refseq": "SAF-like transcription modulator; SAFB-like transcription modulator isoform a; modulator of estrogen induced transcription", "tax_id": 10090, "disease": "", "pathway": " (mmu:66660)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;17242355;17525332;17630952;18630941;19131326;19144319;21183079;21750661;24129315;25428506;26495903;30084848;30782847;34418053;34428180;34887587;37772583", "class_list": "", "function": "Impact of SMAD2 and MET Expression on Lymph Node Metastasis of HER2-positive Gastric Cancer Cells., [RefSeq, PubMed]; Inhibition of gene expression by STLM appears to result from generalized down-regulation of mRNA synthesis and initiation of apoptosis following SLTM overexpression., [RefSeq, PubMed]; SLTM regulates GLI factor binding to chromatin and contributes to the transcriptional outcomes of SHH signaling via a novel molecular mechanism., [RefSeq, PubMed]; When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UYE5;Q8BP76;Q8BR40;Q8VCF4;Q9CS57", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q8CH25-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D3S3-1", "uniprot_id": [ { "id": "SNX29_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D3S3", "type": "external" } ], "mass": 91387.0, "length": 818, "protein_name": "Sorting nexin-29", "gene_name": "Snx29", "organism": "Mouse", "refseq_name": "sorting nexin-29 isoform b", "refseq_ac": [ { "id": "NP_001277077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277077", "type": "external" } ], "gene_names_uniprotkb": "Snx29", "gene_names_refseq": "4933437K13Rik; Gm11170; Gm1737; Gm930; Rundc2a; Snx29", "protein_names_uniprotkb": "Sorting nexin-29", "protein_names_refseq": "RUN domain containing 2A; sorting nexin-29 isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:74478)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17242355;19144319;21183079;21750661;34428180;36210013", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K050", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D3S3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62312-2", "uniprot_id": [ { "id": "TGFR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62312", "type": "external" } ], "mass": 64219.0, "length": 567, "protein_name": "TGF-beta receptor type-2", "gene_name": "Tgfbr2", "organism": "Mouse", "refseq_name": "TGF-beta receptor type-2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_033397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033397", "type": "external" } ], "gene_names_uniprotkb": "Tgfbr2", "gene_names_refseq": "1110020H15Rik; DNIIR; RIIDN; TBR-II; TbetaR-II; TbetaRII; Tgfbr2", "protein_names_uniprotkb": "TGF-beta receptor type-2; 2.7.11.30; TGF-beta receptor type II; TGF-beta type II receptor; TGFR-2; TbetaR-II; Transforming growth factor-beta receptor type II", "protein_names_refseq": "TGF-beta receptor II; TGF-beta receptor type II; TGF-beta receptor type-2 isoform 1 precursor; TGF-beta receptor type-2; TGF-beta type II receptor; TGFR-2; transforming growth factor-beta receptor type II", "tax_id": 10090, "disease": "Loeys-Dietz syndrome (Disease Ontology:DOID:0050466); small intestine carcinoid neuroendocrine tumor (Disease Ontology:DOID:0050925); Loeys-Dietz syndrome 2 (Disease Ontology:DOID:0070234); hereditary nonpolyposis colorectal cancer type 6 (Disease Ontology:DOID:0070273); cleft soft palate (Disease Ontology:DOID:0110214); mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); prostate cancer (Disease Ontology:DOID:10283); DiGeorge syndrome (Disease Ontology:DOID:11198); Marfan syndrome (Disease Ontology:DOID:14323); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); arteriosclerosis (Disease Ontology:DOID:2349); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); pulmonary fibrosis (Disease Ontology:DOID:3770); Lynch syndrome (Disease Ontology:DOID:3883); vasculogenic impotence (Disease Ontology:DOID:4762); cholangiocarcinoma (Disease Ontology:DOID:4947); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); cleft palate (Disease Ontology:DOID:674); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:21813); (R-MMU-2173788); (R-MMU-2173789); (R-MMU-2173791); (R-MMU-9839389)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11801660;18174260;19144319;21183079;26495903;26740625;28011936;31599954;32152506;7957954;8119124", "class_list": "", "function": "Has transforming growth factor beta-activated receptor activity., [UniProtKB, UniProtKB]; Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 25, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q63947", "ec_number_list": [ { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0019209 kinase activator activity;GO:0034714 type III transforming growth factor beta receptor binding;GO:0060090 molecular adaptor activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0002666 positive regulation of T cell tolerance induction;GO:1990086 lens fiber cell apoptotic process;GO:0060439 trachea morphogenesis;GO:0035162 embryonic hemopoiesis;GO:0060443 mammary gland morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q62312-2", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUR2-1", "uniprot_id": [ { "id": "ECI2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUR2", "type": "external" } ], "mass": 43268.0, "length": 391, "protein_name": "Enoyl-CoA delta isomerase 2", "gene_name": "Eci2", "organism": "Mouse", "refseq_name": "enoyl-CoA delta isomerase 2 isoform a", "refseq_ac": [ { "id": "NP_001103801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103801", "type": "external" } ], "gene_names_uniprotkb": "Eci2; Peci", "gene_names_refseq": "Acbd2; Drs1; Eci2; Hca88; Peci", "protein_names_uniprotkb": "Enoyl-CoA delta isomerase 2; 5.3.3.8; D3,D2-enoyl-CoA isomerase; Delta(3),delta(2)-enoyl-CoA isomerase; Dodecenoyl-CoA isomerase; Peroxisomal 3,2-trans-enoyl-CoA isomerase; pECI", "protein_names_refseq": "D3,D2-enoyl-CoA isomerase; delta(3),delta(2)-enoyl-CoA isomerase; dodecenoyl-CoA isomerase; enoyl-CoA delta isomerase 2 isoform a; enoyl-CoA delta isomerase 2, mitochondrial; peroxisomal 3,2-trans-enoyl-CoA isomerase; peroxisomal delta3, delta2-enoyl-Coenzyme A isomerase", "tax_id": 10090, "disease": "", "pathway": " (mmu:23986); (R-MMU-390247); (R-MMU-9033241)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10419495;18250455;18299400;19224205;20173027;21750661;21952136;23576753;23806337;24344334;25428507;25605945;33649389;34428180;35820727;36288343;37453647;37507081;39927985", "class_list": "", "function": "Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species (PubMed:24344334). Has a preference for 3-trans substrates (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99M61;Q9D785", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0000062 fatty-acyl-CoA binding;GO:0004165 delta(3)-delta(2)-enoyl-CoA isomerase activity;GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0009062 fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9WUR2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21855-1", "uniprot_id": [ { "id": "CD72_MOUSE", "url": "https://www.uniprot.org/uniprot/P21855", "type": "external" } ], "mass": 40347.0, "length": 354, "protein_name": "B-cell differentiation antigen CD72", "gene_name": "Cd72", "organism": "Mouse", "refseq_name": "B-cell differentiation antigen CD72 isoform 2", "refseq_ac": [ { "id": "NP_031680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031680", "type": "external" } ], "gene_names_uniprotkb": "Cd72; Ly-32; Ly32; Lyb-2", "gene_names_refseq": "CD72c; Cd72; Ly-19; Ly-32; Ly-m19; Lyb-2", "protein_names_uniprotkb": "B-cell differentiation antigen CD72; Ly-32; Lyb-2; Lymphocyte antigen 32", "protein_names_refseq": "B-cell differentiation antigen CD72 isoform 2; B-cell differentiation antigen CD72; lymphocyte antigen 32", "tax_id": 10090, "disease": "", "pathway": " (mmu:12517); (R-MMU-416700)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10549631;16075062;1634777;21750661;24950378;2645579;27810925;28011936;31262443;31883832;38754236;9590210;9723705", "class_list": "glycogene", "function": "CD22 and CD72 contribute to the development of scleroderma in a murine model., [RefSeq, PubMed]; CD72 appears to specifically inhibit B cell response to the endogenous TLR7 ligand Sm/RNP., [RefSeq, PubMed]; CD72 is an inhibitory pattern recognition receptor that recognizes ribosomes and suppresses production of anti-ribosome autoantibody., [RefSeq, PubMed]; Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions (PubMed:10549631). Recognizes the Sm/ribonucleoprotein (RNP) self-antigen ligand, and coligation of CD72 and BCR inhibits BCR signaling (PubMed:27810925). Mechanistically, ligand binding leads to the recruitment of PTPN6/SHP-1 to the BCR complex which is inhibitory to BCR signaling (PubMed:9590210). Acts also as a ligand for CD5 and thereby plays a critical role in maintaining regulatory T and B-cell homeostasis (PubMed:24950378, PubMed:9723705)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Reverse Arthus reaction model in the skin was induced in mice lacking CD22 (CD22-/-), CD72 (CD72-/-), and both of them (CD22-/-/CD72-/-) by immune complex challenge. Results demonstrate that CD22 and CD72 expression contribute to the development of the reverse Arthus reaction model and CD22 and CD72 might be therapeutic targets for human IC-mediated diseases., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 76, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AIN6;Q64225", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0030246 carbohydrate binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050859 negative regulation of B cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P21855-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.100.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88445-1", "uniprot_id": [ { "id": "AURKC_MOUSE", "url": "https://www.uniprot.org/uniprot/O88445", "type": "external" } ], "mass": 32358.0, "length": 276, "protein_name": "Aurora kinase C", "gene_name": "Aurkc", "organism": "Mouse", "refseq_name": "aurora kinase C", "refseq_ac": [ { "id": "NP_001074435", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074435", "type": "external" } ], "gene_names_uniprotkb": "Aurkc; Aie1; Aik3; Airk3; Ark3; Stk13", "gene_names_refseq": "AIE1; AIK3; ARK-3; Aurkc; IAK3; Stk13", "protein_names_uniprotkb": "Aurora kinase C; 2.7.11.1; ARK-3; Aurora 3; Aurora-related kinase 3; Aurora/IPL1-related kinase 3; Aurora/IPL1/Eg2 protein 1; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C", "protein_names_refseq": "aurora 3; aurora B; aurora kinase C; aurora-related kinase 3; aurora/IPL1-related kinase 3; aurora/Ipl1/Eg2 protein 1; serine/threonine kinase 13 (aurora/IPL-like); serine/threonine-protein kinase 13; serine/threonine-protein kinase aurora-C", "tax_id": 10090, "disease": "spermatogenic failure 5 (Disease Ontology:DOID:0070183); brain cancer (Disease Ontology:DOID:1319)", "pathway": " (mmu:20871)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11098217;11879579;21613325;21750661;30415701;33172986;35255953;9809744", "class_list": "", "function": "Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; In the absence of AURKC, AURKA localizes to chromosomes in a CPC-dependent manner. These data suggest that AURKC prevents AURKA from localizing to chromosomes by competing for CPC binding. This competition is important for adequate spindle length to support meiosis I. There is also a unique requirement for AURKB to negatively regulate AURKC to prevent aneuploidy., [RefSeq, PubMed]; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'., [UniProtKB, PubMed, PubMed]; Using ZINC08918027 inhibitor to determine Aurora kinase-chromosomal passenger complex isoforms in mouse oocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P209;Q9JLC2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0051233 spindle midzone;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0051301 cell division;GO:0046777 protein autophosphorylation;GO:0007052 mitotic spindle organization;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O88445-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83940-1", "uniprot_id": [ { "id": "ELOC_MOUSE", "url": "https://www.uniprot.org/uniprot/P83940", "type": "external" } ], "mass": 12473.0, "length": 112, "protein_name": "Elongin-C", "gene_name": "Eloc", "organism": "Mouse", "refseq_name": "elongin-C isoform 1", "refseq_ac": [ { "id": "NP_001297399", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297399", "type": "external" } ], "gene_names_uniprotkb": "Eloc; Tceb1", "gene_names_refseq": "2610043E24Rik; 2610301I15Rik; Eloc; Tceb1", "protein_names_uniprotkb": "Elongin-C; EloC; Elongin 15 kDa subunit; RNA polymerase II transcription factor SIII subunit C; SIII p15; Stromal membrane-associated protein SMAP1B homolog; Transcription elongation factor B polypeptide 1", "protein_names_refseq": "RNA polymerase II transcription factor SIII subunit C; SIII p15; elongin 15 kDa subunit; elongin-C isoform 1; stromal membrane-associated protein SMAP1B homolog; transcription elongation factor B (SIII), polypeptide 1; transcription elongation factor B polypeptide 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67923); (R-MMU-112382); (R-MMU-1234176); (R-MMU-674695); (R-MMU-6796648); (R-MMU-75955); (R-MMU-8951664); (R-MMU-9705462); (R-MMU-983168); (R-MMU-9954709)", "pathway_count": 10, "publication_count": 15, "publication_id_list": "10051596;11384984;16498413;21750661;22872234;23897481;27863225;27863226;30031227;31219806;33590678;34428180;35978186;36210013;9869640", "class_list": "", "function": "Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins (PubMed:33590678, PubMed:35978186). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes (By similarity). Component the von Hippel-Lindau ubiquitination complex CBC(VHL) (By similarity). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The ECS(ASB9) complex mediates ubiquitination and degradation of CKB (By similarity). As part of a multisubunit ubiquitin ligase complex, polyubiquitinates monoubiquitinated POLR2A (By similarity). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (PubMed:33590678). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (By similarity). The ECS(ASB7) complex acts a negative regulator of H3K9me3 histone mark by mediating ubiquitination and degradation of SUV39H1 (By similarity). As part of the ECS(LRRC58) complex, mediates CDO1 ubiquitination and degradation, regulating cysteine catabolism (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; EPOP (E130012A19Rik) functionally links elongin B, elongin C, and polycomb in pluripotent stem cells., [RefSeq, PubMed]; EPOP (E130012A19Rik) interacts with elongin B, elongin C, and USP7 to modulate the chromatin landscape. Erratum:[Mol Cell. 2017 Jan 5;65(1):202. doi: 10.1016/j.molcel.2016.12.006. PMID: 28061330], [RefSeq, PubMed]; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites (By similarity). Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (PubMed:27863225, PubMed:27863226)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63182", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0044877 protein-containing complex binding;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0030891 VCB complex;GO:0005829 cytosol;GO:0031462 Cul2-RING ubiquitin ligase complex;GO:0031466 Cul5-RING ubiquitin ligase complex;GO:0070449 elongin complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P83940-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99K99-1", "uniprot_id": [ { "id": "PGKA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99K99", "type": "external" } ], "mass": 33916.0, "length": 313, "protein_name": "PDCD10 and GCKIII kinases-associated protein 1", "gene_name": "Pgcka1", "organism": "Mouse", "refseq_name": "PDCD10 and GCKIII kinases-associated protein 1", "refseq_ac": [ { "id": "NP_083830", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083830", "type": "external" } ], "gene_names_uniprotkb": "Pgcka1; 0610040J01Rik", "gene_names_refseq": "0610040J01Rik; Pgcka1", "protein_names_uniprotkb": "PDCD10 and GCKIII kinases-associated protein 1", "protein_names_refseq": "PDCD10 and GCKIII kinases-associated protein 1; uncharacterized protein C4orf19 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:76261)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17242355;21183079;21750661;34428180", "class_list": "", "function": "Acts as a tumor suppressor. Acts as a tumor suppressor for colorectal cancer cell proliferation by targeting KEAP1/USP17/ELK1/CDK6 axis., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQG8;Q9DCE0", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99K99-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62388-1", "uniprot_id": [ { "id": "ATM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62388", "type": "external" } ], "mass": 349418.0, "length": 3066, "protein_name": "Serine-protein kinase ATM", "gene_name": "Atm", "organism": "Mouse", "refseq_name": "serine-protein kinase ATM", "refseq_ac": [ { "id": "NP_031525", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031525", "type": "external" } ], "gene_names_uniprotkb": "Atm", "gene_names_refseq": "Atm; C030026E19Rik", "protein_names_uniprotkb": "Serine-protein kinase ATM; 2.7.11.1; A-T mutated homolog; Ataxia telangiectasia mutated homolog", "protein_names_refseq": "A-T mutated homolog; ataxia telangiectasia gene mutated in human beings; ataxia telangiectasia mutated homolog; serine-protein kinase ATM", "tax_id": 10090, "disease": "female breast cancer (Disease Ontology:DOID:0050671); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); lymphoma (Disease Ontology:DOID:0060058); pre-malignant neoplasm (Disease Ontology:DOID:0060071); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); leukemia (Disease Ontology:DOID:1240); ataxia telangiectasia (Disease Ontology:DOID:12704); endometrial cancer (Disease Ontology:DOID:1380); Parkinson's disease (Disease Ontology:DOID:14330); disease of cellular proliferation (Disease Ontology:DOID:14566); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); breast carcinoma (Disease Ontology:DOID:3459); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); papillary thyroid carcinoma (Disease Ontology:DOID:3969); infertility (Disease Ontology:DOID:5223); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); lung small cell carcinoma (Disease Ontology:DOID:5409); prostate carcinoma in situ (Disease Ontology:DOID:8634); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); oral mucosa leukoplakia (Disease Ontology:DOID:9655); senile cataract (Disease Ontology:DOID:9669)", "pathway": " (mmu:11920); (R-MMU-2559586); (R-MMU-349425); (R-MMU-5685938); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693548); (R-MMU-5693565); (R-MMU-5693568); (R-MMU-5693571); (R-MMU-5693579); (R-MMU-5693607); (R-MMU-5693616); (R-MMU-6803204); (R-MMU-6803207); (R-MMU-6804756); (R-MMU-6804757); (R-MMU-6804760); (R-MMU-69473); (R-MMU-69541); (R-MMU-9664873)", "pathway_count": 21, "publication_count": 27, "publication_id_list": "11571274;16906133;18833288;19047460;19234633;19448632;21183079;21706008;21750661;25101980;25428506;25605945;25733712;25936915;30017584;30084848;31219806;33779025;34203471;34428180;35820727;36210013;8661102;8689683;9000145;9697112;9707615", "class_list": "", "function": "Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:19047460). Recognizes the substrate consensus sequence [ST]-Q (PubMed:19047460). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (PubMed:11571274). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes (By similarity). After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele (PubMed:19448632). Also involved in signal transduction and cell cycle control (By similarity). May function as a tumor suppressor (By similarity). Necessary for activation of ABL1 and SAPK (By similarity). Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4, UCHL3 and DCLRE1C (By similarity). May play a role in vesicle and/or protein transport (By similarity). Could play a role in T-cell development, gonad and neurological function (By similarity). Binds DNA ends (By similarity). Plays a role in replication-dependent histone mRNA degradation (By similarity). Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (By similarity). Phosphorylates ATF2 which stimulates its function in DNA damage response (By similarity). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (By similarity). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (By similarity). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QNY7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "1.14.11.69", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0000045 autophagosome assembly;GO:0006281 DNA repair;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q62388-1", "record_type": "protein", "filter_code": "0000000.1100111.001000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925I1-1", "uniprot_id": [ { "id": "ATD3A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q925I1", "type": "external" } ], "mass": 66742.0, "length": 591, "protein_name": "ATPase family AAA domain-containing protein 3A", "gene_name": "Atad3a", "organism": "Mouse", "refseq_name": "ATPase family AAA domain-containing protein 3A", "refseq_ac": [ { "id": "NP_849534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849534", "type": "external" } ], "gene_names_uniprotkb": "Atad3a; Atad3; Kiaa1273", "gene_names_refseq": "2400004H09Rik; Atad3a; Atad3; Tob3; mKIAA1273", "protein_names_uniprotkb": "ATPase family AAA domain-containing protein 3A; 3.6.1.-; AAA-ATPase TOB3", "protein_names_refseq": "AAA-ATPase TOB3; ATPase family AAA domain-containing protein 3A; ATPase family AAA domain-containing protein 3", "tax_id": 10090, "disease": "Harel-Yoon syndrome (Disease Ontology:DOID:0081395); neonatal lethal pontocerebellar hypoplasia, hypotonia, and respiratory insufficiency syndrome (Disease Ontology:DOID:0081396)", "pathway": " (mmu:108888); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "12865426;20332122;21750661;23372768;23576753;23806337;28135057;29187734;33300544;34428180;36000457;36736924;37453647;37828378;38250153;38923254", "class_list": "", "function": "ATAD3 is a limiting factor in mitochondrial biogenesis and adipogenesis of white adipocyte-like 3T3-L1 cells., [RefSeq, PubMed]; ATAD3 is present in five native mitochondrial protein complexes of different sizes, indicating complex roles of the protein in mitochondrial architecture and function., [RefSeq, PubMed]; Deletion of ATAD3A inhibits osteogenesis by impairing mitochondria structure and function in pre-osteoblast., [RefSeq, PubMed]; Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important role in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis. Involved in mitochondrial-mediated antiviral innate immunity. Required to protect mitochondria from the PERK-mediated unfolded protein response: specifically inhibits the activity of EIF2AK3/PERK at mitochondria-endoplasmic reticulum contact sites, thereby providing a safe haven for mitochondrial protein translation during endoplasmic reticulum stress. Ability to inhibit EIF2AK3/PERK is independent of its ATPase activity. Also involved in the mitochondrial DNA damage response by promoting signaling between damaged genomes and the mitochondrial membrane, leading to activation of the integrated stress response (ISR)., [UniProtKB, UniProtKB]; Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis., [RefSeq, PubMed]; The SIRT3-ATAD3A axis regulates MAM dynamics and mitochondrial calcium homeostasis in cardiac hypertrophy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AD89;Q3TA78;Q3UE74;Q69ZM7;Q8C6C6", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0042645 mitochondrial nucleoid;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006974 DNA damage response;GO:0001558 regulation of cell growth;GO:0007005 mitochondrion organization;GO:1903898 negative regulation of PERK-mediated unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q925I1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXC6-1", "uniprot_id": [ { "id": "DDX11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6AXC6", "type": "external" } ], "mass": 101968.0, "length": 906, "protein_name": "ATP-dependent DNA helicase DDX11", "gene_name": "Ddx11", "organism": "Mouse", "refseq_name": "ATP-dependent DNA helicase DDX11 isoform 1", "refseq_ac": [ { "id": "NP_001003919", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003919", "type": "external" } ], "gene_names_uniprotkb": "Ddx11", "gene_names_refseq": "4732462I11Rik; CHL1; CHLR1; Ddx11; KRG2; essa15a", "protein_names_uniprotkb": "ATP-dependent DNA helicase DDX11; 5.6.2.3; DEAD/H-box protein 11; DNA 5'-3' helicase DDX11", "protein_names_refseq": "ATP-dependent DNA helicase DDX11 isoform 1; ATP-dependent DNA helicase DDX11; DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae); DNA 5'-3' helicase DDX11; probable ATP-dependent RNA helicase DDX11", "tax_id": 10090, "disease": "Warsaw breakage syndrome (Disease Ontology:DOID:0060535)", "pathway": " (mmu:320209)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17611414;21750661;21854770;25428506;30084848;31219806;32152506", "class_list": "", "function": "ChlR1 is essential for embryonic development and the prevention of aneuploidy in mammals., [RefSeq, PubMed]; DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis. Its double-stranded DNA helicase activity requires either a minimal 5'-single-stranded tail length of approximately 15 nt (flap substrates) or 10 nt length single-stranded gapped DNA substrates of a partial duplex DNA structure for helicase loading and translocation along DNA in a 5' to 3' direction. The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended up to 500 bp by the replication protein A (RPA) or the cohesion CTF18-replication factor C (Ctf18-RFC) complex activities. Also shows ATPase- and helicase activities on substrates that mimic key DNA intermediates of replication, repair and homologous recombination reactions, including forked duplex, anti-parallel G-quadruplex and three-stranded D-loop DNA molecules. Plays a role in DNA double-strand break (DSB) repair at the DNA replication fork during DNA replication recovery from DNA damage. Recruited with TIMELESS factor upon DNA-replication stress response at DNA replication fork to preserve replication fork progression, and hence ensure DNA replication fidelity (By similarity). Also cooperates with TIMELESS factor during DNA replication to regulate proper sister chromatid cohesion and mitotic chromosome segregation (PubMed:17611414). Stimulates 5'-single-stranded DNA flap endonuclease activity of FEN1 in an ATP- and helicase-independent manner; and hence it may contribute in Okazaki fragment processing at DNA replication fork during lagging strand DNA synthesis. Its ability to function at DNA replication fork is modulated by its binding to long non-coding RNA (lncRNA) cohesion regulator non-coding RNA DDX11-AS1/CONCR, which is able to increase both DDX11 ATPase activity and binding to DNA replicating regions (By similarity). Also plays a role in heterochromatin organization (PubMed:21854770). Involved in rRNA transcription activation through binding to active hypomethylated rDNA gene loci by recruiting UBTF and the RNA polymerase Pol I transcriptional machinery (By similarity). Plays a role in embryonic development and prevention of aneuploidy (PubMed:17611414). Involved in melanoma cell proliferation and survival. Associates with chromatin at DNA replication fork regions. Binds to single- and double-stranded DNAs (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A286YDJ5", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0045142 triplex DNA binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005813 centrosome", "go_biological_process": "GO:0035563 positive regulation of chromatin binding;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0032091 negative regulation of protein binding;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6AXC6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18911-1", "uniprot_id": [ { "id": "RARG_MOUSE", "url": "https://www.uniprot.org/uniprot/P18911", "type": "external" } ], "mass": 50891.0, "length": 458, "protein_name": "Retinoic acid receptor gamma", "gene_name": "Rarg", "organism": "Mouse", "refseq_name": "retinoic acid receptor gamma isoform 2", "refseq_ac": [ { "id": "NP_001036192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036192", "type": "external" } ], "gene_names_uniprotkb": "Rarg; Nr1b3", "gene_names_refseq": "Nr1b3; RAR-gamma; RARD; RARgamma2; Rarg", "protein_names_uniprotkb": "Retinoic acid receptor gamma; Nuclear receptor subfamily 1 group B member 3; RAR-gamma", "protein_names_refseq": "RAR gamma 2; nuclear receptor subfamily 1 group B member 3; retinoic acid receptor gamma 4; retinoic acid receptor gamma isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:19411); (R-MMU-383280); (R-MMU-5362517)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "15327771;19389355;20043900;2157210;2157970;21750661;24129315;2544807;31219806;36446525;8388780", "class_list": "", "function": "Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (By similarity). Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function., [UniProtKB, PubMed, PubMed]; Synergistic activation of RARbeta and RARgamma nuclear receptors restores cell specialization during stem cell differentiation by hijacking RARalpha-controlled programs. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P20787;Q3UG86;Q62149;Q91VK5;Q91YX2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0060429 epithelium development;GO:0002068 glandular epithelial cell development;GO:0060534 trachea cartilage development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P18911-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZ32-1", "uniprot_id": [ { "id": "ASXL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZ32", "type": "external" } ], "mass": 147107.0, "length": 1370, "protein_name": "Putative Polycomb group protein ASXL2", "gene_name": "Asxl2", "organism": "Mouse", "refseq_name": "putative Polycomb group protein ASXL2 isoform 1", "refseq_ac": [ { "id": "NP_001257917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257917", "type": "external" } ], "gene_names_uniprotkb": "Asxl2; Kiaa1685", "gene_names_refseq": "4930556B16Rik; Asxl2; mKIAA1685", "protein_names_uniprotkb": "Putative Polycomb group protein ASXL2; Additional sex combs-like protein 2", "protein_names_refseq": "additional sex combs like 2, transcriptional regulator; additional sex combs-like protein 2; polycomb group protein ASXH2 homolog; putative Polycomb group protein ASXL2 isoform 1; putative Polycomb group protein ASXL2", "tax_id": 10090, "disease": "", "pathway": " (mmu:75302); (R-MMU-5689603)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21490954;21750661;24129315;25428506;30084848;32747411;34428180;36068610;36852467;40997131", "class_list": "", "function": "ASXL1/2 mutations and myeloid malignancies. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as a coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3 (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (By similarity). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:32747411). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (PubMed:32747411). ASXL1 and ASXL2 are important for BAP1 protein stability (By similarity)., [UniProtKB, UniProtKB, PubMed]; The knockdown of Asxl2 in bone marrow macrophages impaired their ability to form osteoclasts., [RefSeq, PubMed]; This gene encodes a homolog of the Drosophila Asx gene, which interacts with genes involved in axial patterning. Mice with mutations in this gene display abnormal patterning of the axial skeleton, suggesting a similar function in mice as in Drosophila. This gene may also be involved in bone mineral density, specifically osteoclastogenesis. [provided by RefSeq, Aug 2012]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRU9;Q80TA5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042975 peroxisome proliferator activated receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035517 PR-DUB complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0045600 positive regulation of fat cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8BZ32-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXF6-1", "uniprot_id": [ { "id": "SIDT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6AXF6", "type": "external" } ], "mass": 93896.0, "length": 827, "protein_name": "SID1 transmembrane family member 1", "gene_name": "Sidt1", "organism": "Mouse", "refseq_name": "SID1 transmembrane family member 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001152891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152891", "type": "external" } ], "gene_names_uniprotkb": "Sidt1", "gene_names_refseq": "B830021E24Rik; Sidt1", "protein_names_uniprotkb": "SID1 transmembrane family member 1", "protein_names_refseq": "SID1 transmembrane family member 1 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:320007)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25605945;26067272;27046251;30899004;31061008;32801357", "class_list": "", "function": "In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp (PubMed:26067272). Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded (PubMed:27046251)., [UniProtKB, PubMed, PubMed]; SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs., [RefSeq, PubMed]; This study shows that SIDT1 localizes to endolysosomes and mediates double-stranded RNA transport into the cytoplasm, however, SIDT1-deficient animals showed no impairment in survival postinfection with either HSV type 1 or encephalomyocarditis virus, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 9, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q8R397", "ec_number_list": [], "go_molecular_function": "GO:0015485 cholesterol binding;GO:0003725 double-stranded RNA binding;GO:0051033 RNA transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0016020 membrane", "go_biological_process": "GO:0050658 RNA transport", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q6AXF6-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGN4-1", "uniprot_id": [ { "id": "BCOR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CGN4", "type": "external" } ], "mass": 192631.0, "length": 1759, "protein_name": "BCL-6 corepressor", "gene_name": "Bcor", "organism": "Mouse", "refseq_name": "BCL-6 corepressor isoform d", "refseq_ac": [ { "id": "NP_001161793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161793", "type": "external" } ], "gene_names_uniprotkb": "Bcor; Kiaa1575", "gene_names_refseq": "2900008C10Rik; 5830466J11Rik; 8430401K06Rik; BcorR; Bcor; D930024N20Rik; mKIAA1575", "protein_names_uniprotkb": "BCL-6 corepressor; BCoR", "protein_names_refseq": "BCL-6 corepressor isoform d; BCL-6 corepressor", "tax_id": 10090, "disease": "syndromic microphthalmia 1 (Disease Ontology:DOID:0111799); syndromic microphthalmia 2 (Disease Ontology:DOID:0111809); stomach cancer (Disease Ontology:DOID:10534); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); dental caries (Disease Ontology:DOID:216); stomach carcinoma (Disease Ontology:DOID:5517); cataract (Disease Ontology:DOID:83); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:71458)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "12522145;12776190;17242355;21183079;21750661;25428506;30084848;30779550;31219806;32782141;34203471;34428180;35820727;35984892;36084651;36210013;36852467;40997131", "class_list": "", "function": "Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2) (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B1AXK3;B1AXK4;B1AXK5;B1AXK6;Q6PDK5;Q6ZPM3;Q8BKF5;Q8CGN1;Q8CGN2;Q8CGN3", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0031072 heat shock protein binding;GO:0042826 histone deacetylase binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0140261 BCOR complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q8CGN4-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64012-1", "uniprot_id": [ { "id": "RALY_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64012", "type": "external" } ], "mass": 33188.0, "length": 312, "protein_name": "RNA-binding protein Raly", "gene_name": "Raly", "organism": "Mouse", "refseq_name": "RNA-binding protein Raly short isoform", "refseq_ac": [ { "id": "NP_001132983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001132983", "type": "external" } ], "gene_names_uniprotkb": "Raly; Merc", "gene_names_refseq": "Merc; Raly", "protein_names_uniprotkb": "RNA-binding protein Raly; Maternally-expressed hnRNP C-related protein; hnRNP associated with lethal yellow protein", "protein_names_refseq": "RNA-binding protein Raly short isoform; RNA-binding protein Raly; hnRNP associated with lethal yellow protein; maternally-expressed hnRNP C-related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:19383)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10500250;17242355;18630941;19144319;21183079;21750661;22645316;23806337;25153642;25605945;26495903;27251289;28135057;29187734;32080181;34383386;34428180;37371543;37507081;8050375;8319910", "class_list": "", "function": "Downregulation of a Dorsal Root Ganglion-Specifically Enriched Long Noncoding RNA is Required for Neuropathic Pain by Negatively Regulating RALY-Triggered Ehmt2 Expression., [RefSeq, PubMed]; Effects of the Combination of the C1473G Mutation in the Tph2 Gene and Lethal Yellow Mutations in the Raly-Agouti Locus on Behavior, Brain 5-HT and Melanocortin Systems in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Liver-specific deletion of RALY alters hepatic lipid content and serum cholesterol level. RALY binds the promoter region of the master metabolic regulator Srebp2 and show that it directly interacts with coactivator Nuclear Transcription Factor Y (NFY) to influence cholesterogenic gene expression. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver (PubMed:27251289). Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (PubMed:27251289). May be a heterogeneous nuclear ribonucleoprotein (hnRNP) (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AU63;Q99K76;Q9CXH8;Q9QZX6", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0042632 cholesterol homeostasis;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q64012-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RV46-1", "uniprot_id": [ { "id": "SPA6L_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RV46", "type": "external" } ], "mass": 39981.0, "length": 347, "protein_name": "Spermatogenesis associated 6-like protein", "gene_name": "Spata6l", "organism": "Mouse", "refseq_name": "spermatogenesis associated 6-like protein isoform 2", "refseq_ac": [ { "id": "NP_941053", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_941053", "type": "external" } ], "gene_names_uniprotkb": "Spata6l; 4430402I18Rik", "gene_names_refseq": "4430402I18Rik; Spata6l", "protein_names_uniprotkb": "Spermatogenesis associated 6-like protein", "protein_names_refseq": "spermatogenesis associated 6-like protein isoform 2; spermatogenesis associated 6-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:381218)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032027 myosin light chain binding", "go_cellular_component": "GO:0120212 sperm head-tail coupling apparatus", "go_biological_process": "GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B2RV46-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CIF6-1", "uniprot_id": [ { "id": "SIDT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CIF6", "type": "external" } ], "mass": 94501.0, "length": 832, "protein_name": "SID1 transmembrane family member 2", "gene_name": "Sidt2", "organism": "Mouse", "refseq_name": "SID1 transmembrane family member 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001276597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276597", "type": "external" } ], "gene_names_uniprotkb": "Sidt2", "gene_names_refseq": "B930096O19; CGI-40; Sidt2", "protein_names_uniprotkb": "SID1 transmembrane family member 2", "protein_names_refseq": "SID1 transmembrane family member 2 isoform 1 precursor", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208)", "pathway": " (mmu:214597)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "19349973;20965152;21183079;21750661;23776622;26067272;27046251;27233614;27846365;27987306;28277980;28724756;31219806;31944164;32565723;33715196;34428180;34923568", "class_list": "", "function": "Cytosolic domain of SIDT2 carries an arginine-rich motif that binds to RNA/DNA and is important for the direct transport of nucleic acids into lysosomes., [RefSeq, PubMed]; Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA and DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded (PubMed:27046251, PubMed:27846365, PubMed:28724756). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980). In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA (PubMed:27846365). Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (PubMed:26067272)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Sidt2 is a highly glycosylated lysosomal integral membrane protein that shows tissue-specific expression., [RefSeq, PubMed]; Sidt2 is a key protein in the autophagy-lysosomal degradation pathway and is essential for the maintenance of kidney structure and filtration function. Publication Status: Online-Only, [RefSeq, PubMed]; The Effects of Sidt2 on the Inflammatory Pathway in Mouse Mesangial Cells. Publication Status: Online-Only, [RefSeq, PubMed]; The lysosomal membrane protein Sidt2 is a vital regulator of mitochondrial quality control in skeletal muscle., [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q80XD7;Q922R2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0035612 AP-2 adaptor complex binding;GO:0003725 double-stranded RNA binding;GO:0035650 AP-1 adaptor complex binding;GO:0051033 RNA transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0016020 membrane", "go_biological_process": "GO:0000902 cell morphogenesis;GO:0042593 glucose homeostasis;GO:0009749 response to glucose;GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0050658 RNA transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8CIF6-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09M02-1", "uniprot_id": [ { "id": "CBPC5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q09M02", "type": "external" } ], "mass": 97607.0, "length": 886, "protein_name": "Cytosolic carboxypeptidase-like protein 5", "gene_name": "Agbl5", "organism": "Mouse", "refseq_name": "cytosolic carboxypeptidase-like protein 5 isoform 3", "refseq_ac": [ { "id": "NP_001041657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041657", "type": "external" } ], "gene_names_uniprotkb": "Agbl5; Ccp5", "gene_names_refseq": "9430057O19Rik; Agbl5; CCP5", "protein_names_uniprotkb": "Cytosolic carboxypeptidase-like protein 5; 3.4.17.-; 3.4.17.24; ATP/GTP-binding protein-like 5; Protein deglutamylase CCP5", "protein_names_refseq": "carboxypeptidase 5, cytosolic; cytosolic carboxypeptidase-like protein 5 isoform 3; cytosolic carboxypeptidase-like protein 5; protein deglutamylase CCP5", "tax_id": 10090, "disease": "retinitis pigmentosa 75 (Disease Ontology:DOID:0110361)", "pathway": " (mmu:231093)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17244818;20519502;21074048;21183079;21750661;24022482;25103237;26829768;30635446;31219806", "class_list": "", "function": "CCP5 functions as a dual-functional deglutamylase cleaving both alpha- and gamma-linked glutamate from tubulin., [RefSeq, PubMed]; Loss of the deglutamylase CCP5 perturbs multiple steps of spermatogenesis and leads to male infertility. Publication Status: Online-Only, [RefSeq, PubMed]; Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins (PubMed:20519502, PubMed:21074048, PubMed:24022482, PubMed:26829768). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin (PubMed:20519502, PubMed:21074048, PubMed:24022482). Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate (PubMed:21074048, PubMed:24022482). Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin (PubMed:24022482). Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation (PubMed:26829768)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D3Z6S8;Q09M01;Q09M03;Q09M04;Q6PFZ3;Q8BLL9;Q8BM52;Q8BZD8;Q8C0W4", "ec_number_list": [ { "id": "3.4.17.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.-", "type": "external" }, { "id": "3.4.17.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.24", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity;GO:0015631 tubulin binding;GO:0008237 metallopeptidase activity;GO:0004180 carboxypeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0030496 midbody", "go_biological_process": "GO:0006508 proteolysis;GO:0051607 defense response to virus;GO:0035610 protein side chain deglutamylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q09M02-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80Y56-1", "uniprot_id": [ { "id": "RBNS5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80Y56", "type": "external" } ], "mass": 88491.0, "length": 783, "protein_name": "Rabenosyn-5", "gene_name": "Rbsn", "organism": "Mouse", "refseq_name": "rabenosyn-5", "refseq_ac": [ { "id": "NP_084357", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084357", "type": "external" } ], "gene_names_uniprotkb": "Rbsn; Zfyve20", "gene_names_refseq": "5330426D11Rik; Rbsn; Zfyve20", "protein_names_uniprotkb": "Rabenosyn-5; FYVE finger-containing Rab5 effector protein rabenosyn-5; RAB effector RBSN; Zinc finger FYVE domain-containing protein 20", "protein_names_refseq": "FYVE finger-containing Rab5 effector protein rabenosyn-5; RAB effector RBSN; rabenosyn-5; zinc finger FYVE domain-containing protein 20", "tax_id": 10090, "disease": "Kariminejad neurodevelopmental syndrome (Disease Ontology:DOID:0061158)", "pathway": " (mmu:78287); (R-MMU-168138); (R-MMU-983231)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;34428180;35820727", "class_list": "", "function": "Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3). Plays a role in the recycling of transferrin receptor to the plasma membrane (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0L6;Q9CTW0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031267 small GTPase binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0015031 protein transport;GO:0090160 Golgi to lysosome transport;GO:0034498 early endosome to Golgi transport;GO:1903358 regulation of Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q80Y56-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FF7-1", "uniprot_id": [ { "id": "SLAI1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q68FF7", "type": "external" } ], "mass": 61307.0, "length": 579, "protein_name": "SLAIN motif-containing protein 1", "gene_name": "Slain1", "organism": "Mouse", "refseq_name": "SLAIN motif-containing protein 1 isoform 2", "refseq_ac": [ { "id": "NP_932131", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932131", "type": "external" } ], "gene_names_uniprotkb": "Slain1", "gene_names_refseq": "9630044O09Rik; Slain1", "protein_names_uniprotkb": "SLAIN motif-containing protein 1", "protein_names_refseq": "SLAIN motif-containing protein 1 isoform 2; SLAIN motif-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:105439)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;16546155;20563991;21646404;21750661;22517741;22645316;23077057;24129315;32848054;35822049;36852467;40021952;40885482", "class_list": "", "function": "Data suggest that Slain1 may play a role in the development of the nervous system, as well as in the morphogenesis of several embryonic structures., [RefSeq, PubMed]; Expressed at the stem cell and epiblast stages of embryonic stem cell differentiation and in the epiblast, nervous system, tailbud and somites of the developing mouse embryo., [RefSeq, PubMed]; Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elongation., [UniProtKB, PubMed]; SLAIN1 is highly enriched in brain and expressed throughout brain development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3I6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005856 cytoskeleton", "go_biological_process": "GO:0007020 microtubule nucleation;GO:0031116 positive regulation of microtubule polymerization;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q68FF7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGH4-1", "uniprot_id": [ { "id": "REEP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGH4", "type": "external" } ], "mass": 22285.0, "length": 201, "protein_name": "Receptor expression-enhancing protein 1", "gene_name": "Reep1", "organism": "Mouse", "refseq_name": "receptor expression-enhancing protein 1", "refseq_ac": [ { "id": "NP_848723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848723", "type": "external" } ], "gene_names_uniprotkb": "Reep1; D6Ertd253e", "gene_names_refseq": "D6Ertd253e; Reep1", "protein_names_uniprotkb": "Receptor expression-enhancing protein 1", "protein_names_refseq": "receptor expression-enhancing protein 1", "tax_id": 10090, "disease": "autosomal recessive distal hereditary motor neuronopathy 6 (Disease Ontology:DOID:0081425); hereditary spastic paraplegia 31 (Disease Ontology:DOID:0110782); autosomal dominant distal hereditary motor neuronopathy 12 (Disease Ontology:DOID:0111205)", "pathway": " (mmu:52250)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "15345747;15550249;21183079;21750661;24478229;24668814;30084848;30779550;32878877;35348668;36520405", "class_list": "", "function": "Functional mutation analysis reveal that distinct pathomechanisms are associated with REEP1 mutations and shed new light on its probable functions., [RefSeq, PubMed]; Inhibition of ER stress improves progressive motor deficits in a REEP1-null mouse model of hereditary spastic paraplegia. Publication Status: Online-Only, [RefSeq, PubMed]; REEP1 Preserves Motor Function in SOD1[G93A] Mice by Improving Mitochondrial Function via Interaction with NDUFA4., [RefSeq, PubMed]; Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors (By similarity)., [UniProtKB, PubMed]; Transverse endoplasmic reticulum expansion in hereditary spastic paraplegia corticospinal axons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0031849 olfactory receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0032386 regulation of intracellular transport;GO:0071786 endoplasmic reticulum tubular network organization;GO:0051205 protein insertion into membrane", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BGH4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D415-1", "uniprot_id": [ { "id": "DLGP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D415", "type": "external" } ], "mass": 110374.0, "length": 992, "protein_name": "Disks large-associated protein 1", "gene_name": "Dlgap1", "organism": "Mouse", "refseq_name": "disks large-associated protein 1 isoform 5", "refseq_ac": [ { "id": "NP_001334340", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334340", "type": "external" } ], "gene_names_uniprotkb": "Dlgap1; Gkap; Kiaa4162", "gene_names_refseq": "4933422O14Rik; 9630002F18; D17Bwg0511e; Dlgap1; GKAP/SAPAP; GKPA/SAPAP; Gkap; Sapap1; mKIAA4162", "protein_names_uniprotkb": "Disks large-associated protein 1; DAP-1; Guanylate kinase-associated protein; PSD-95/SAP90-binding protein 1; SAP90/PSD-95-associated protein 1; SAPAP1", "protein_names_refseq": "DAP-1 beta; PSD-95/SAP90-binding protein 1; SAP90/PSD-95 associated protein 1; discs, large homolog-associated protein 1; disks large-associated protein 1 isoform 5; disks large-associated protein 1; guanylate kinase-associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:224997); (R-MMU-6794361)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.3389/fragi.2021.757801;15024750;16452087;17114649;19458039;21183079;21750661;22517741;22645316;22826440;24153177;32848054;33347690;34678516;35822049;40021952;40885482", "class_list": "", "function": "Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2., [RefSeq, PubMed]; Part of the postsynaptic scaffold in neuronal cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 18, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 18, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 18, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "Q52KF6;Q5DTK5;Q6P6N4;Q6XBF4;Q8BZL7;Q8BZQ1;Q8C0G0", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019904 protein domain specific binding;GO:0044877 protein-containing complex binding;GO:0098919 structural constituent of postsynaptic density", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0014069 postsynaptic density;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0099092 postsynaptic density, intracellular component", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0050804 modulation of chemical synaptic transmission;GO:0035418 protein localization to synapse;GO:0061136 regulation of proteasomal protein catabolic process;GO:0070842 aggresome assembly", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q9D415-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0T5-1", "uniprot_id": [ { "id": "SI1L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0T5", "type": "external" } ], "mass": 197031.0, "length": 1782, "protein_name": "Signal-induced proliferation-associated 1-like protein 1", "gene_name": "Sipa1l1", "organism": "Mouse", "refseq_name": "signal-induced proliferation-associated 1-like protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001161455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161455", "type": "external" } ], "gene_names_uniprotkb": "Sipa1l1; Kiaa0440", "gene_names_refseq": "4931426N11Rik; Sipa1l1; Spar; mKIAA0440", "protein_names_uniprotkb": "Signal-induced proliferation-associated 1-like protein 1; SIPA1-like protein 1", "protein_names_refseq": "SIPA1-like protein 1; signal-induced proliferation-associated 1-like protein 1 isoform 2; signal-induced proliferation-associated 1-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:217692)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;16452087;17242355;18094260;19131326;19144319;21183079;21750661;22517741;22645316;24129315;28336531;30084848;30779550;31219806;32782141;32848054;33300544;34428180;34678516;34887587;35121636;35822049;36852467;40021952;40885482", "class_list": "", "function": "PDZ domain-containing protein Sipa1l1 (signal-induced proliferation-associated 1 like 1) binds to the cytoplasmic PDZ-ligand motif of aquaporin-2 and accelerates its endocytosis in the absence of vasopressin, [RefSeq, PubMed]; SIPA1L1/SPAR1 Interacts with the Neurabin Family of Proteins and is Involved in GPCR Signaling., [RefSeq, PubMed]; Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 16, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 16, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 16, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 41, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 23, "binding_glycan_count": 0, "secondary_ac_list": "Q6PDI8;Q80U02;Q8C026", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0019901 protein kinase binding;GO:0046875 ephrin receptor binding;GO:0051015 actin filament binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0015629 actin cytoskeleton;GO:0043025 neuronal cell body", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0043087 regulation of GTPase activity;GO:0048013 ephrin receptor signaling pathway;GO:0048814 regulation of dendrite morphogenesis;GO:0051056 regulation of small GTPase mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 5.2, "record_id": "Q8C0T5-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AF47-1", "uniprot_id": [ { "id": "DOC11_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AF47", "type": "external" } ], "mass": 237771.0, "length": 2073, "protein_name": "Dedicator of cytokinesis protein 11", "gene_name": "Dock11", "organism": "Mouse", "refseq_name": "dedicator of cytokinesis protein 11", "refseq_ac": [ { "id": "NP_001009947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947", "type": "external" } ], "gene_names_uniprotkb": "Dock11; Ziz2", "gene_names_refseq": "5033414A21Rik; 8030476J24; Dock11; Zizimin2; sph238", "protein_names_uniprotkb": "Dedicator of cytokinesis protein 11; ACG; Activated Cdc42-associated guanine nucleotide exchange factor; Zizimin-2", "protein_names_refseq": "ACG; activated Cdc42-associated guanine nucleotide exchange factor; dedicator of cytokinesis protein 11; spleen specific 238 kDa protein with PH domain; zizimin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:75974); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-983231)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "15710388;16968698;17242355;20484733;21183079;21750661;22494997;23092103;25729399;25851601;31219806;32878909;34428180;35820727;36210013;37342957", "class_list": "", "function": "Cloning of zizimin2; expressed predominantly in lymphocytes with an opposite pattern than zizimin1 [zizimin2], [RefSeq, PubMed]; Contribution of DOCK11 to the Expansion of Antigen-Specific Populations among Germinal Center B Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:15710388, PubMed:16968698, PubMed:25851601). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (PubMed:25729399). Facilitates filopodia formation through the activation of CDC42 (PubMed:22494997)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency., [RefSeq, PubMed]; These data suggested that Zizimin2 is associated with the reduction of immune response in acquired immunity along with aging., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5KTP7", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "", "go_biological_process": "GO:0043547 positive regulation of GTPase activity;GO:0007264 small GTPase-mediated signal transduction;GO:0035023 regulation of Rho protein signal transduction;GO:0051491 positive regulation of filopodium assembly;GO:0001782 B cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "A2AF47-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98083-1", "uniprot_id": [ { "id": "SHC1_MOUSE", "url": "https://www.uniprot.org/uniprot/P98083", "type": "external" } ], "mass": 62608.0, "length": 579, "protein_name": "SHC-transforming protein 1", "gene_name": "Shc1", "organism": "Mouse", "refseq_name": "SHC-transforming protein 1 isoform a", "refseq_ac": [ { "id": "NP_001106802", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106802", "type": "external" } ], "gene_names_uniprotkb": "Shc1; ShcA; Shc", "gene_names_refseq": "Shc1; ShcA; Shc; p66shc; p66", "protein_names_uniprotkb": "SHC-transforming protein 1; SH2 domain protein C1; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1", "protein_names_refseq": "SH2 domain protein C1; SHC-transforming protein 1 isoform a; SHC-transforming protein 1; SHC-transforming protein A", "tax_id": 10090, "disease": "glomerulosclerosis (Disease Ontology:DOID:0050851); familial hyperlipidemia (Disease Ontology:DOID:1168); hepatocellular carcinoma (Disease Ontology:DOID:684); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:20416); (R-MMU-1250196); (R-MMU-1250347); (R-MMU-167044); (R-MMU-180336); (R-MMU-201556); (R-MMU-210993); (R-MMU-2424491); (R-MMU-2428933); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-354192); (R-MMU-512988); (R-MMU-5654688); (R-MMU-5654699); (R-MMU-5654704); (R-MMU-5654719); (R-MMU-5673001); (R-MMU-74749); (R-MMU-74751); (R-MMU-8851805); (R-MMU-8853659); (R-MMU-8983432); (R-MMU-9009391); (R-MMU-9020558); (R-MMU-9027284); (R-MMU-912526); (R-MMU-9634597); (R-MMU-9674555); (R-MMU-9842663)", "pathway_count": 31, "publication_count": 56, "publication_id_list": "10068665;10080542;10395202;11433297;11948181;12052829;12367511;12571362;12763525;12925710;15467833;15592455;17272725;17431427;17947660;18174162;18956770;19144319;19327338;19665990;20053790;20354186;20547441;20566667;21047172;21183079;21467074;21750661;23386199;23766859;23806337;23832324;25428506;25810038;26868434;27960536;28137876;29624862;29636844;29849865;30084848;30459314;33688230;33760157;34428180;38151356;38444386;38459002;7529871;7798194;8643691;8654924;9083021;9099679;9165038;9885561", "class_list": "", "function": "Hyperglycemic stress induces oxidative damage of enteric glial cells by triggering redoxosomes/p66SHC activation., [RefSeq, PubMed]; P66Shc signaling and autophagy impact on C2C12 myoblast differentiation during senescence. Publication Status: Online-Only, [RefSeq, PubMed]; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p47Shc and isoform p52Shc, once phosphorylated, couple activated receptor kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p47Shc and isoform p52 may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span. Involved in the oncostatin-M-mediated signaling pathway through type II OSM receptor complex (heterodimers composed of OSMR and IL6ST) where it contributes to activation of the Ras/Raf/MAPK pathway through JAK1-dependent recruitment to OSMR subunit of OSMR complex and SHC1 association with GRB2 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; [Study of senescence protein p66[Shc] on myocardial tissue repair in adult mice]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2Q7;Q8BFY3;Q8K4C6;Q8K4C7", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0005158 insulin receptor binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0046875 ephrin receptor binding", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0010008 endosome membrane", "go_biological_process": "GO:1990839 response to endothelin;GO:0001525 angiogenesis;GO:0006940 regulation of smooth muscle contraction;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 5.7, "record_id": "P98083-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C8M1-1", "uniprot_id": [ { "id": "SHCAF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C8M1", "type": "external" } ], "mass": 24829.0, "length": 221, "protein_name": "SIN3-HDAC complex-associated factor", "gene_name": "Sinhcaf", "organism": "Mouse", "refseq_name": "SIN3-HDAC complex-associated factor isoform 1", "refseq_ac": [ { "id": "NP_062617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062617", "type": "external" } ], "gene_names_uniprotkb": "Sinhcaf; Fam60a; Tera", "gene_names_refseq": "Fam60a; Ppcs1; Pptcs1; Sinhcaf; Tera", "protein_names_uniprotkb": "SIN3-HDAC complex-associated factor; Protein FAM60A; Tera protein", "protein_names_refseq": "SIN3-HDAC complex-associated factor isoform 1; family with sequence similarity 60, member A; pluripotent cell-specific 1; protein FAM60A; teratocarcinoma expressed, serine rich", "tax_id": 10090, "disease": "", "pathway": " (mmu:56306)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;25428506;28554894;30070635;30779550;31219806", "class_list": "", "function": "Our data suggest that Fam60a is required for proper embryogenesis, at least in part as a result of its regulation of DNA methylation at specific gene promoters. Publication Status: Online-Only, [RefSeq, PubMed]; Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway (By similarity). Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (PubMed:28554894)., [UniProtKB, PubMed, UniProtKB]; Taken together, Fam60a is an essential core subunit of a variant Sin3a-Hdac complex in embryonic stem cells that is required to promote rapid proliferation and prevent unscheduled differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70361;Q3TLD2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0070822 Sin3-type complex", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0030336 negative regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8C8M1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80U62-1", "uniprot_id": [ { "id": "RUBIC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80U62", "type": "external" } ], "mass": 106860.0, "length": 956, "protein_name": "Run domain Beclin-1-interacting and cysteine-rich domain-containing protein", "gene_name": "Rubcn", "organism": "Mouse", "refseq_name": "run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform a", "refseq_ac": [ { "id": "NP_001186967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186967", "type": "external" } ], "gene_names_uniprotkb": "Rubcn; 1700021K19Rik; Kiaa0226", "gene_names_refseq": "1700021K19Rik; 5330403K09; Rubcn; Rubicon; mKIAA0226", "protein_names_uniprotkb": "Run domain Beclin-1-interacting and cysteine-rich domain-containing protein; Rubicon", "protein_names_refseq": "run domain Beclin-1 interacting and cystein-rich containing protein; run domain Beclin-1 interacting and cysteine-rich containing protein; run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform a; run domain Beclin-1-interacting and cysteine-rich domain-containing protein", "tax_id": 10090, "disease": "autosomal recessive spinocerebellar ataxia 15 (Disease Ontology:DOID:0080057)", "pathway": " (mmu:100502698)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "19144319;19270693;19270696;21183079;21750661;22872234;31219806;34428180", "class_list": "", "function": "Beclin 1 and its binding proteins orchestrate the precise function of the class III PI(3)K in regulating autophagy at multiple steps., [RefSeq, PubMed]; Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process (PubMed:19270693). Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (By similarity)., [UniProtKB, UniProtKB, PubMed]; Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines. Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (By similarity)., [UniProtKB, UniProtKB]; Two Beclin 1 associated proteins, Atg14L and Rubicon, were identified., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAX3;Q3TD96;Q3TDF7;Q3TDU2;Q6NWW8;Q6P9T7;Q6PG18;Q8BMP7;Q8BY22", "ec_number_list": [], "go_molecular_function": "GO:1901981 phosphatidylinositol phosphate binding;GO:0141039 phosphatidylinositol 3-kinase inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005764 lysosome;GO:0005770 late endosome", "go_biological_process": "GO:1901097 negative regulation of autophagosome maturation;GO:0045806 negative regulation of endocytosis;GO:0006897 endocytosis;GO:0006914 autophagy;GO:0010507 negative regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80U62-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RY56-1", "uniprot_id": [ { "id": "RBM25_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RY56", "type": "external" } ], "mass": 99552.0, "length": 838, "protein_name": "RNA-binding protein 25", "gene_name": "Rbm25", "organism": "Mouse", "refseq_name": "RNA-binding protein 25 isoform 2", "refseq_ac": [ { "id": "NP_081625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081625", "type": "external" } ], "gene_names_uniprotkb": "Rbm25", "gene_names_refseq": "2600011C06Rik; 2610015J01Rik; A130095G20Rik; RNPC7; Rbm25", "protein_names_uniprotkb": "RNA-binding protein 25; RNA-binding motif protein 25", "protein_names_refseq": "RNA-binding protein 25 isoform 2; RNA-binding protein 25", "tax_id": 10090, "disease": "", "pathway": " (mmu:67039); (R-MMU-72163); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;17242355;18630941;19131326;19144319;21183079;21750661;23806337;24788674;30635567;34428180;34887587;36947858;39627609;40885482;40997131", "class_list": "", "function": "RNA splicing factor Rbm25 underlies heterogeneous preleukemic clonal expansion in mice., [RefSeq, PubMed]; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA (By similarity)., [UniProtKB]; Tumor suppressive function in acute myeloid leukemia Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPH6;Q3U976;Q3UQU7;Q6NWW2;Q8BVT8;Q91XE6;Q9CT27;Q9CT49", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006397 mRNA processing;GO:0006915 apoptotic process;GO:0008380 RNA splicing;GO:0042981 regulation of apoptotic process;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "B2RY56-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C9B9-1", "uniprot_id": [ { "id": "DIDO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C9B9", "type": "external" } ], "mass": 247176.0, "length": 2256, "protein_name": "Death-inducer obliterator 1", "gene_name": "Dido1", "organism": "Mouse", "refseq_name": "death-inducer obliterator 1 isoform Dido1", "refseq_ac": [ { "id": "NP_001278361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278361", "type": "external" } ], "gene_names_uniprotkb": "Dido1; Datf1; Dio1", "gene_names_refseq": "6720461J16Rik; C130092D22Rik; D130048F08Rik; DATF-1; DIO-1; Datf1; Dido1; dido", "protein_names_uniprotkb": "Death-inducer obliterator 1; DATF-1; DIO-1; Death-associated transcription factor 1", "protein_names_refseq": "death inducer-obliterator-2; death inducer-obliterator-3; death-associated transcription factor 1; death-inducer obliterator 1 isoform Dido1", "tax_id": 10090, "disease": "myelodysplastic/myeloproliferative neoplasm (Disease Ontology:DOID:4972)", "pathway": " (mmu:23856)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;10393935;16127461;17242355;17299043;19557426;20485683;21183079;21606357;21750661;21952136;22517741;22645316;24129315;25428506;31219806;34155199;34428180;34678516;34887587;36852467;38194457;38247850;40021952;40885482;40997131", "class_list": "", "function": "DIDO is necessary for the adipogenesis that promotes diet-induced obesity., [RefSeq, PubMed]; Data suggest that Dido might be one of the tumor suppressor genes at chromosome 20q and that the Dido-targeted mouse may be a suitable model for studying myeloproliferative diseases and myelodysplastic syndromes., [RefSeq, PubMed]; Dido3, the largest splice variant of the Dido gene, is a centrosome-associated protein whose disruption leads to supernumerary centrosomes, failure to maintain cellular mitotic arrest, and early degradation of the mitotic checkpoint protein BubR1., [RefSeq, PubMed]; Impaired stem cell differentiation and somatic cell reprogramming in DIDO3 mutants with altered RNA processing and increased R-loop levels. Publication Status: Online-Only, [RefSeq, PubMed]; PARP1, DIDO3, and DHX9 Proteins Mutually Interact in Mouse Fibroblasts, with Effects on DNA Replication Dynamics, Senescence, and Oncogenic Transformation. Publication Status: Online-Only, [RefSeq, PubMed]; Required for early embryonic stem cell development (By similarity). Putative transcription factor, weakly pro-apoptotic when overexpressed., [UniProtKB]; Results indicate that histone H3 lysine 4 demethylation modulates DIDO3 localization in meiosis and suggest epigenetic regulation of the synaptonemal complex, [RefSeq, PubMed]; This gene encodes a transcription factor involved in apoptosis. The encoded protein functions in cell cycle progression and plays a role in chromosomal stability. This protein regulates the self-renewal of embryonic stem cells. Disruption of this gene in mice causes symptoms similar to myelodysplastic/myeloproliferative diseases in humans. Mice lacking this gene show severely reduced fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 14, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 14, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 14, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "A2AJ47;A2AJ48;B2RS46;Q05C59;Q3ZTP5;Q3ZTP6;Q4V9W1;Q6ZQD7;Q80V34;Q8BMD0;Q8BRG2;Q8CHR5;Q9WV00", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0097190 apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "Q8C9B9-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C090-1", "uniprot_id": [ { "id": "RC3H2_MOUSE", "url": "https://www.uniprot.org/uniprot/P0C090", "type": "external" } ], "mass": 131295.0, "length": 1187, "protein_name": "Roquin-2", "gene_name": "Rc3h2", "organism": "Mouse", "refseq_name": "roquin-2 isoform a", "refseq_ac": [ { "id": "NP_001094061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094061", "type": "external" } ], "gene_names_uniprotkb": "Rc3h2; Mnab", "gene_names_refseq": "2900024N03Rik; 9430019J22Rik; D930043C02Rik; Mnab; Rc3h2; Rnf164", "protein_names_uniprotkb": "Roquin-2; 2.3.2.27; Membrane-associated nucleic acid-binding protein; RING finger and CCCH-type zinc finger domain-containing protein 2; RING-type E3 ubiquitin transferase Roquin-2", "protein_names_refseq": "RING-type E3 ubiquitin transferase Roquin-2; membrane associated DNA binding protein; membrane-associated nucleic acid binding protein; ring finger and CCCH-type zinc finger domain-containing protein 2; roquin-2 isoform a; roquin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:319817)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10938276;21750661;22517741;22645316;22826440;23550652;23583642;23583643;23663784;25282160;25428506;25697406;29237092;30084848;30779550;32782141;32848054;34428180;34678516;36852467;38729452;40021952;40885482", "class_list": "", "function": "Characterization of the human RC3H2 ortholog and observation of conserved sequences in mouse., [RefSeq, PubMed]; Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (PubMed:23663784). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (PubMed:23583642, PubMed:23583643). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (PubMed:25282160). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains. Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains. Involved in the ubiquitination of MAP3K5 (By similarity). Able to interact with double-stranded RNA (dsRNA)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; RING-deficient Roquin-1 failed to localize to stress granules and allowed Roquin-2 to compensate in the repression of ICOS and Tfh cells., [RefSeq, PubMed]; Roquin-1 and Roquin-2 proteins redundantly repressed the mRNA of inducible costimulator (Icos) and identified the Ox40 costimulatory receptor as another shared mRNA target., [RefSeq, PubMed]; Roquin-2 promotes oxidative stress-induced cell death by ubiquitination-dependent degradation of TAK1., [RefSeq, PubMed]; Study demonstrates that the constitutive decay element folds into an RNA stem-loop motif that is specifically recognized by Roquin and Roquin2. Binding of Roquin initiates degradation of TNF-alpha mRNA and limits TNF-alpha production in macrophages., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 31, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 31, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 31, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 33, "binding_glycan_count": 0, "secondary_ac_list": "A2AVP5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0009986 cell surface;GO:0016020 membrane;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:2000320 negative regulation of T-helper 17 cell differentiation;GO:0048286 lung alveolus development;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0010608 post-transcriptional regulation of gene expression;GO:0050852 T cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 5.6, "record_id": "P0C090-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30545-1", "uniprot_id": [ { "id": "ADA2B_MOUSE", "url": "https://www.uniprot.org/uniprot/P30545", "type": "external" } ], "mass": 50443.0, "length": 453, "protein_name": "Alpha-2B adrenergic receptor", "gene_name": "Adra2b", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Adra2b", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptor subtype C2; Alpha-2B adrenoceptor; Alpha-2B adrenoreceptor; Alpha-2BAR", "protein_names_refseq": "", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); myocardial infarction (Disease Ontology:DOID:5844); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11552); (R-MMU-390696); (R-MMU-392023); (R-MMU-418594); (R-MMU-418597)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "1336396;1354956;34428180;35820727", "class_list": "", "function": "Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (PubMed:1354956). ADRA2B physiological agonists includes norepinephrine and epinephrine (PubMed:1354956)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8VQ23", "ec_number_list": [], "go_molecular_function": "GO:0004938 alpha2-adrenergic receptor activity;GO:0051379 epinephrine binding;GO:0004935 adrenergic receptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0001525 angiogenesis;GO:0003056 regulation of vascular associated smooth muscle contraction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P30545-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88992-1", "uniprot_id": [ { "id": "C1QRF_MOUSE", "url": "https://www.uniprot.org/uniprot/O88992", "type": "external" } ], "mass": 26500.0, "length": 258, "protein_name": "C1q-related factor", "gene_name": "C1ql1", "organism": "Mouse", "refseq_name": "C1q-related factor precursor", "refseq_ac": [ { "id": "NP_035925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035925", "type": "external" } ], "gene_names_uniprotkb": "C1ql1; C1qrf; Crf; Ctrp14", "gene_names_refseq": "Adil; C1ql1; C1qrf; CRF; CTRP14; gliacolin", "protein_names_uniprotkb": "C1q-related factor; C1q and tumor necrosis factor-related protein 14; C1q/TNF-related protein 14; CTRP14; Complement component 1 Q subcomponent-like 1", "protein_names_refseq": "C1q and tumor necrosis factor-related protein 14; C1q-related factor precursor; C1q-related factor; C1q/TNF-related protein 14; adiponectin l", "tax_id": 10090, "disease": "", "pathway": " (mmu:23829)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19275900;21262840;23449976;35403439;9878755", "class_list": "", "function": "CTRP14 inactivation alters physical activity and food intake response to fasting and refeeding., [RefSeq, PubMed]; Conserved recoding RNA editing of vertebrate C1q-related factor C1QL1., [RefSeq, PubMed]; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AH89", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0043083 synaptic cleft;GO:0098793 presynapse", "go_biological_process": "GO:0016322 neuron remodeling;GO:0061743 motor learning;GO:0099558 maintenance of synapse structure;GO:0099550 trans-synaptic signaling, modulating synaptic transmission;GO:1905806 regulation of synapse pruning", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O88992-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MQ1-1", "uniprot_id": [ { "id": "BICC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MQ1", "type": "external" } ], "mass": 105037.0, "length": 977, "protein_name": "Protein bicaudal C homolog 1", "gene_name": "Bicc1", "organism": "Mouse", "refseq_name": "protein bicaudal C homolog 1 isoform 1", "refseq_ac": [ { "id": "NP_113574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113574", "type": "external" } ], "gene_names_uniprotkb": "Bicc1", "gene_names_refseq": "Bic-C; Bicc1; bpk; jcpk", "protein_names_uniprotkb": "Protein bicaudal C homolog 1; Bic-C", "protein_names_refseq": "juvenile congenital polycystic kidney disease; polycystic kidney mutation of BALB/c origin; protein bicaudal C homolog 1 isoform 1; protein bicaudal C homolog 1", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); cystic renal dysplasia (Disease Ontology:DOID:0111682); cystic kidney disease (Disease Ontology:DOID:2975); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (mmu:83675)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11231089;19324013;21183079;21750661;25671767;31219806;34210974;34428180;35756494", "class_list": "", "function": "Expression and Regulatory Network Analysis of BICC1 for Aged Sca-1-Positive Bone Narrow Mesenchymal Stem Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex. Publication Status: Online-Only, [RefSeq, PubMed]; Putative RNA-binding protein. May be involved in regulating gene expression during embryonic development., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6K3;Q8C286", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007507 heart development;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0001822 kidney development;GO:0007368 determination of left/right symmetry;GO:0006402 mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99MQ1-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09047-1", "uniprot_id": [ { "id": "C3AR_MOUSE", "url": "https://www.uniprot.org/uniprot/O09047", "type": "external" } ], "mass": 53576.0, "length": 477, "protein_name": "C3a anaphylatoxin chemotactic receptor", "gene_name": "C3ar1", "organism": "Mouse", "refseq_name": "C3a anaphylatoxin chemotactic receptor", "refseq_ac": [ { "id": "NP_033909", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033909", "type": "external" } ], "gene_names_uniprotkb": "C3ar1; C3r1", "gene_names_refseq": "AZ3B; C3AR; C3ar1; HNFAG09", "protein_names_uniprotkb": "C3a anaphylatoxin chemotactic receptor; C3AR; C3a-R; Complement component 3a receptor 1", "protein_names_refseq": "C3a anaphylatoxin chemotactic receptor; C3a-R; anaphylatoxin C3a receptor", "tax_id": 10090, "disease": "adult respiratory distress syndrome (Disease Ontology:DOID:11394); asthma (Disease Ontology:DOID:2841); rhinitis (Disease Ontology:DOID:4483); lung disease (Disease Ontology:DOID:850)", "pathway": " (mmu:12267); (R-MMU-375276); (R-MMU-418594); (R-MMU-6798695); (R-MMU-977606)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "21183079;25456411;27802388;31219806;38713526;38778507;38866102;9164946;9382922;9694514", "class_list": "", "function": "Adipsin and adipocyte-derived C3aR1 regulate thermogenic fat in a sex-dependent fashion. Publication Status: Online-Only, [RefSeq, PubMed]; Complement C3aR signaling: Immune and metabolic modulation and its impact on Alzheimer's disease. Review article, [RefSeq, PubMed]; Microglia aggravate white matter injury via C3/C3aR pathway after experimental subarachnoid hemorrhage., [RefSeq, PubMed]; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a, stimulating chemotaxis, granule enzyme release and superoxide anion production (PubMed:9164946, PubMed:9382922). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). C3AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O35951", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0001850 complement component C3a binding;GO:0004876 complement component C3a receptor activity;GO:0004878 complement component C5a receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0072126 positive regulation of glomerular mesangial cell proliferation;GO:0002430 complement receptor mediated signaling pathway;GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O09047-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O89001-1", "uniprot_id": [ { "id": "CBPD_MOUSE", "url": "https://www.uniprot.org/uniprot/O89001", "type": "external" } ], "mass": 152406.0, "length": 1377, "protein_name": "Carboxypeptidase D", "gene_name": "Cpd", "organism": "Mouse", "refseq_name": "carboxypeptidase D precursor", "refseq_ac": [ { "id": "NP_031780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031780", "type": "external" } ], "gene_names_uniprotkb": "Cpd", "gene_names_refseq": "Cpd; D830034L15Rik", "protein_names_uniprotkb": "Carboxypeptidase D; 3.4.17.22; Metallocarboxypeptidase D; gp180", "protein_names_refseq": "carboxypeptidase D precursor; gp180; metallocarboxypeptidase D", "tax_id": 10090, "disease": "", "pathway": " (mmu:12874); (R-MMU-432722); (R-MMU-9696264); (R-MMU-9696273)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11891854;12643288;17242355;19349973;21183079;22872234;25428506;26740625;30899004;31219806;33300544;34428180;37828378;9490632;9714835", "class_list": "", "function": "CPD localization to the TGN requires both static retention involving the C-terminal domain and phosphorylation at a CK2 site, which regulates the binding of adaptor proteins., [RefSeq, PubMed]; Functions in the processing of proteins and peptides in the secretory pathway. Mechanistically, cleaves exclusively C-terminal basic residues. By removing terminal residues, can modulate the activity, stability, and receptor-binding properties of bioactive peptides., [UniProtKB, UniProtKB]; Palmitoylation of carboxypeptidase D has a role in intracellular trafficking, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 11, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 11, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 11, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 11, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 16, "disease_count": 0, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "Q5SVH8", "ec_number_list": [ { "id": "3.4.17.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.22", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.3.2", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding;GO:0004181 metallocarboxypeptidase activity;GO:0051721 protein phosphatase 2A binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0016485 protein processing;GO:0006518 peptide metabolic process", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "O89001-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZM7-1", "uniprot_id": [ { "id": "CDC73_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZM7", "type": "external" } ], "mass": 60577.0, "length": 531, "protein_name": "Parafibromin", "gene_name": "Cdc73", "organism": "Mouse", "refseq_name": "parafibromin", "refseq_ac": [ { "id": "NP_666103", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666103", "type": "external" } ], "gene_names_uniprotkb": "Cdc73", "gene_names_refseq": "8430414L16Rik; C130030P16Rik; Cdc73; Hrpt2", "protein_names_uniprotkb": "Parafibromin; Cell division cycle protein 73 homolog; Hyperparathyroidism 2 protein homolog", "protein_names_refseq": "cell division cycle protein 73 homolog; hyperparathyroidism 2 protein homolog; parafibromin", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); hyperparathyroidism (Disease Ontology:DOID:13543); parathyroid carcinoma (Disease Ontology:DOID:1540); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); lung adenocarcinoma (Disease Ontology:DOID:3910); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:214498); (R-MMU-112382); (R-MMU-201722); (R-MMU-5632684); (R-MMU-674695); (R-MMU-75955); (R-MMU-8866654)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "15580289;18212049;19345177;21750661;27749823;27864380;28288139;28384511;31031188;34428180", "class_list": "", "function": "Cell division cycle 73 (CDC73) Is esential for embryonic and adult matopoiesis and Indispensable for acute myeloid leukemia (AML), [RefSeq, PubMed]; Expression of Hrpt2 and parafibromin is pivotal in mammalian development and survival in adults and that these functions are likely mediated by the transcriptional regulation of growth factors., [RefSeq, PubMed]; These results aid in our understanding of the role parafibromin plays within transcriptional regulation, terminal differentiation, and bone homeostasis, [RefSeq, PubMed]; Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors (By similarity)., [UniProtKB, PubMed]; Uterine neoplasms, myometria and jaw bones of Cdc73(+/-) mice had increased proliferation rates that were 2-fold higher than in Cdc73(+/+) mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016593 Cdc73/Paf1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8JZM7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YV10-1", "uniprot_id": [ { "id": "CCD13_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YV10", "type": "external" } ], "mass": 79750.0, "length": 709, "protein_name": "Coiled-coil domain-containing protein 13", "gene_name": "Ccdc13", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 13", "refseq_ac": [ { "id": "NP_082660", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082660", "type": "external" } ], "gene_names_uniprotkb": "Ccdc13", "gene_names_refseq": "2900041A11Rik; Ccdc13; Gm188", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 13", "protein_names_refseq": "coiled-coil domain-containing protein 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:100502861)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;34428180", "class_list": "", "function": "Required for primary cilia formation and promotes the localization of the ciliopathy protein BBS4 to both centriolar satellites and cilia., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005813 centrosome;GO:0034451 centriolar satellite;GO:0036064 ciliary basal body;GO:0097540 axonemal central pair", "go_biological_process": "GO:0006974 DNA damage response;GO:1905515 non-motile cilium assembly;GO:0035082 axoneme assembly;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3YV10-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPY4-1", "uniprot_id": [ { "id": "CDKA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPY4", "type": "external" } ], "mass": 13202.0, "length": 127, "protein_name": "Cyclin-dependent kinase 2-associated protein 2", "gene_name": "Cdk2ap2", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 2-associated protein 2", "refseq_ac": [ { "id": "NP_080649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080649", "type": "external" } ], "gene_names_uniprotkb": "Cdk2ap2; D19Ertd144e; Doc1r", "gene_names_refseq": "5830466O21Rik; Cdk2ap2; D19Ertd144e; Doc-1r", "protein_names_uniprotkb": "Cyclin-dependent kinase 2-associated protein 2; CDK2-associated protein 2; DOC-1-related protein; DOC-1R", "protein_names_refseq": "CDK2-associated protein 2; DOC-1 related protein; cyclin-dependent kinase 2-associated protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:52004); (R-MMU-9937850); (R-MMU-9940951)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12451986;12944431;21750661;22548356;23074223;34428180", "class_list": "", "function": "Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (By similarity). Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs (PubMed:22548356). Regulates microtubule organization of metaphase II oocytes (PubMed:12944431)., [UniProtKB, PubMed, UniProtKB, PubMed]; Cdk2ap2 under normal conditions has a biphasic expression, suggesting regulatory roles in early-versus-late stem cell differentiation., [RefSeq, PubMed]; Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1), an essential gene for early embryonic development, plays a role in pluripotency of ESC by engaging MBD3 to the promoter region of Wnt signaling genes, [RefSeq, PubMed]; Identified a mitogen-activated protein kinase partner, DOC1R, a murine homologue of a potential human tumor suppressor gene; characterized DOC1R during mouse oocyte meiosis resumption, [RefSeq, PubMed]; Mouse DOC-1R gene can significantly inhibit cell growth and colony formation capacity., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0016581 NuRD complex", "go_biological_process": "GO:2000134 negative regulation of G1/S transition of mitotic cell cycle;GO:2000035 regulation of stem cell division;GO:0070507 regulation of microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CPY4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17892-1", "uniprot_id": [ { "id": "LIPR2_MOUSE", "url": "https://www.uniprot.org/uniprot/P17892", "type": "external" } ], "mass": 54017.0, "length": 482, "protein_name": "Pancreatic lipase-related protein 2", "gene_name": "Pnliprp2", "organism": "Mouse", "refseq_name": "pancreatic lipase-related protein 2 precursor", "refseq_ac": [ { "id": "NP_035258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035258", "type": "external" } ], "gene_names_uniprotkb": "Pnliprp2; Plrp2", "gene_names_refseq": "PLRP2; Pnliprp2", "protein_names_uniprotkb": "Pancreatic lipase-related protein 2; 3.1.1.26; 3.1.1.3; Cytotoxic T lymphocyte lipase; Galactolipase; PL-RP2; Triacylglycerol lipase", "protein_names_refseq": "PL-RP2; cytotoxic T-lymphocyte lipase; galactolipase; pancreatic lipase-related protein 2 precursor; triacylglycerol lipase", "tax_id": 10090, "disease": "", "pathway": " (mmu:18947); (R-MMU-192456)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "14704305;17805199;19451396;21382969;2302735;31199585;32428799;32963038;37468762;9813028", "class_list": "", "function": "BSSL and PLRP2 responsible for fat digestion as long as milk is the main food. Milk-borne BSSL is able to compensate for a slower ontogeny of pancreatic BSSL expression in the mouse., [RefSeq, PubMed]; Decreased T-cell mediated hepatic injury in concanavalin A-treated PLRP2-deficient mice., [RefSeq, PubMed]; Lipase that primarily hydrolyzes triglycerides and galactosylglycerides (PubMed:21382969, PubMed:9813028). In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides (PubMed:9813028). Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity (PubMed:21382969). Can completely deacylate triacylglycerols (By similarity). When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids (By similarity). Hydrolyzes medium- and long-chain fatty acyls in galactolipids (By similarity). May act together with LIPF to hydrolyze partially digested triglycerides (By similarity). Hydrolyzes long-chain monoglycerides with high efficiency (By similarity). In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (PubMed:19451396, PubMed:2302735, PubMed:9813028). Also has low phospholipase activity (By similarity). In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids (By similarity). The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Our results indicate that Plrp2 can be activated in the liver and is responsible for the increased RE hydrolases (REH) activity in the liver of mice fed vitamin A-deficient diet (VAD), [RefSeq, PubMed]; PLRP2 selectively localizes synaptic membrane proteins via acyl-chain remodeling of phospholipids., [RefSeq, PubMed]; Pancreatic lipase-related protein 2 is selectively expressed by peritubular myoid cells in the murine testis and sustains long-term spermatogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Study concluded that pancreatic lipase-related protein 2 is the major colipase-dependent lipase in the pancreas of newborn mice, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q4VBW7", "ec_number_list": [ { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0016298 lipase activity;GO:0004620 phospholipase activity;GO:0047372 monoacylglycerol lipase activity;GO:0005509 calcium ion binding;GO:0008970 phospholipase A1 activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0043005 neuron projection;GO:0042589 zymogen granule membrane", "go_biological_process": "GO:0044258 intestinal lipid catabolic process;GO:0034638 phosphatidylcholine catabolic process;GO:0006633 fatty acid biosynthetic process;GO:0006968 cellular defense response;GO:0009395 phospholipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P17892-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TYD6-1", "uniprot_id": [ { "id": "LMTK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TYD6", "type": "external" } ], "mass": 160508.0, "length": 1471, "protein_name": "Serine/threonine-protein kinase LMTK2", "gene_name": "Lmtk2", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase LMTK2", "refseq_ac": [ { "id": "NP_001074578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074578", "type": "external" } ], "gene_names_uniprotkb": "Lmtk2; Brek; Kiaa1079", "gene_names_refseq": "2900041G10Rik; A330101P12Rik; BREK; KPI-2; KPI2; Lmtk2; aatyk2; cprk", "protein_names_uniprotkb": "Serine/threonine-protein kinase LMTK2; 2.7.11.1; Brain-enriched kinase; Lemur tyrosine kinase 2", "protein_names_refseq": "apoptosis-associated tyrosine kinase 2; brain-enriched kinase; serine/threonine-protein kinase LMTK2", "tax_id": 10090, "disease": "", "pathway": " (mmu:231876)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15005709;17651901;19144319;21183079;31722791", "class_list": "", "function": "LMTK2 overexpression alleviated oxygen-glucose deprivation/reoxygenation-induced neuronal apoptosis and oxidative damage by enhancing Nrf2/antioxidant response element antioxidant signaling via modulation of GSK-3beta phosphorylation., [RefSeq, PubMed]; Phosphorylates PPP1C, phosphorylase b and CFTR., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6BLY9;Q6PDK6;Q6ZPY9;Q8CA34", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004864 protein phosphatase inhibitor activity;GO:0070853 myosin VI binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0030426 growth cone", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007399 nervous system development;GO:0046777 protein autophosphorylation;GO:0045022 early endosome to late endosome transport;GO:0018107 peptidyl-threonine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3TYD6-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54829-1", "uniprot_id": [ { "id": "RGS7_MOUSE", "url": "https://www.uniprot.org/uniprot/O54829", "type": "external" } ], "mass": 54792.0, "length": 469, "protein_name": "Regulator of G protein signaling 7", "gene_name": "Rgs7", "organism": "Mouse", "refseq_name": "regulator of G-protein signaling 7 isoform 1", "refseq_ac": [ { "id": "NP_036010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036010", "type": "external" } ], "gene_names_uniprotkb": "Rgs7", "gene_names_refseq": "Rgs7", "protein_names_uniprotkb": "Regulator of G protein signaling 7; RGS7", "protein_names_refseq": "Regulator of G-protein signaling 7 (RGS7); regulator of G-protein signaling 7 isoform 1", "tax_id": 10090, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:24012); (R-MMU-418594); (R-MMU-6814122)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10862767;15632198;15897264;17114649;21183079;21750661;22689652;25792749;30546127;31311860;33300544;33402347;36574707;9459445", "class_list": "", "function": "A RGS7-CaMKII complex drives myocyte-intrinsic and myocyte-extrinsic mechanisms of chemotherapy-induced cardiotoxicity., [RefSeq, PubMed]; Deletion of GPR158 or RGS7 enhanced excitability of layer 2/3 PFC neurons and prevented the impact of stress., [RefSeq, PubMed]; GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades (PubMed:25792749). The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form (By similarity). May play a role in synaptic vesicle exocytosis (By similarity). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (PubMed:30546127, PubMed:31311860). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Striatal RGS7 Regulates Depression-Related Behaviors and Stress-Induced Reinstatement of Cocaine Conditioned Place Preference. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QLB9", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0005096 GTPase activator activity;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0051286 cell tip;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0043547 positive regulation of GTPase activity;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:1901381 positive regulation of potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "O54829-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R361-1", "uniprot_id": [ { "id": "RFIP5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R361", "type": "external" } ], "mass": 69553.0, "length": 645, "protein_name": "Rab11 family-interacting protein 5", "gene_name": "Rab11fip5", "organism": "Mouse", "refseq_name": "rab11 family-interacting protein 5 isoform 1", "refseq_ac": [ { "id": "NP_001003955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003955", "type": "external" } ], "gene_names_uniprotkb": "Rab11fip5; D6Ertd32e; GAF1; Rip11", "gene_names_refseq": "9130206P09Rik; D6Ertd32e; GAF1; RIP11; Rab11fip5", "protein_names_uniprotkb": "Rab11 family-interacting protein 5; Rab11-FIP5; Rab11-interacting protein Rip11", "protein_names_refseq": "rab11 family-interacting protein 5 isoform 1; rab11 family-interacting protein 5; rab11-FIP5; rab11-interacting protein Rip11", "tax_id": 10090, "disease": "", "pathway": " (mmu:52055)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;19144319;19335615;21183079;21750661;22517741;22645316;25605945;26515129;31219806;32782141;32848054;33172842;34428180;35822049;36210013;36852467;40021952;40885482", "class_list": "", "function": "RAB11FIP5-Deficient Mice Exhibit Cytokine-Related Transcriptomic Signatures. Publication Status: Online-Only, [RefSeq, PubMed]; Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The ability of insulin to increase the appearance of Rip11 at the cell surface involves an inhibition of Rip11 internalisation from the plasma membrane, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "C4IXU4", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0097227 sperm annulus;GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0070164 negative regulation of adiponectin secretion;GO:0098884 postsynaptic neurotransmitter receptor internalization;GO:0045055 regulated exocytosis;GO:0071346 cellular response to type II interferon;GO:0071468 cellular response to acidic pH", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q8R361-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BK67-1", "uniprot_id": [ { "id": "RCC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BK67", "type": "external" } ], "mass": 55983.0, "length": 520, "protein_name": "Protein RCC2", "gene_name": "Rcc2", "organism": "Mouse", "refseq_name": "protein RCC2", "refseq_ac": [ { "id": "NP_776292", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776292", "type": "external" } ], "gene_names_uniprotkb": "Rcc2; Kiaa1470", "gene_names_refseq": "2610510H01Rik; 2610529N02Rik; Rcc2; Td60; mKIAA1470", "protein_names_uniprotkb": "Protein RCC2", "protein_names_refseq": "protein RCC2", "tax_id": 10090, "disease": "", "pathway": " (mmu:108911); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 8, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;17242355;18250455;18299400;20173027;21183079;21750661;21952136;22645316;23806337;25074804;25153642;25428506;25605945;28135057;28528544;28869598;30084848;30779550;31219806;32801160;34428180;34887587;35984892;37507081;39627609;40021952", "class_list": "", "function": "Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both during interphase and during mitosis. Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles. Required for normal organization of the microtubule cytoskeleton in interphase cells. Functions as a guanine nucleotide exchange factor (GEF) for RALA. Interferes with the activation of RAC1 by guanine nucleotide exchange factors (By similarity). Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions (PubMed:25074804). Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro) (By similarity)., [UniProtKB, UniProtKB, PubMed]; RCC2 Promotes Esophageal Cancer Growth by Regulating Activity and Expression of the Sox2 Transcription Factor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2AWQ3;Q6ZPQ0", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:1900027 regulation of ruffle assembly;GO:0010762 regulation of fibroblast migration;GO:0007229 integrin-mediated signaling pathway;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q8BK67-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58069-1", "uniprot_id": [ { "id": "RASA2_MOUSE", "url": "https://www.uniprot.org/uniprot/P58069", "type": "external" } ], "mass": 96401.0, "length": 847, "protein_name": "Ras GTPase-activating protein 2", "gene_name": "Rasa2", "organism": "Mouse", "refseq_name": "ras GTPase-activating protein 2", "refseq_ac": [ { "id": "NP_444498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444498", "type": "external" } ], "gene_names_uniprotkb": "Rasa2", "gene_names_refseq": "5430433H21Rik; GAP1m; Rasa2", "protein_names_uniprotkb": "Ras GTPase-activating protein 2; GAP1m", "protein_names_refseq": "ras GTPase-activating protein 2", "tax_id": 10090, "disease": "Noonan syndrome (Disease Ontology:DOID:3490)", "pathway": " (mmu:114713); (R-MMU-5658442)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21183079;21750661;31219806;34428180;8702543", "class_list": "", "function": "Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) and phospholipids., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G3X918", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005543 phospholipid binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0035556 intracellular signal transduction;GO:1902531 regulation of intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P58069-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54726-1", "uniprot_id": [ { "id": "RD23A_MOUSE", "url": "https://www.uniprot.org/uniprot/P54726", "type": "external" } ], "mass": 39706.0, "length": 363, "protein_name": "Lysine-specific demethylase RAD23A", "gene_name": "Rad23a", "organism": "Mouse", "refseq_name": "lysine-specific demethylase RAD23A isoform 1", "refseq_ac": [ { "id": "NP_001284535", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284535", "type": "external" } ], "gene_names_uniprotkb": "Rad23a; Mhr23a", "gene_names_refseq": "2310040P19Rik; HR23A; Rad23a; mHR23A", "protein_names_uniprotkb": "Lysine-specific demethylase RAD23A; 1.14.11.-; HR23A; UV excision repair protein RAD23 homolog A; mHR23A", "protein_names_refseq": "RAD23a homolog; UV excision repair protein RAD23 homolog A; lysine-specific demethylase RAD23A isoform 1; lysine-specific demethylase RAD23A", "tax_id": 10090, "disease": "", "pathway": " (mmu:19358); (R-MMU-5689877); (R-MMU-5696394); (R-MMU-5696395)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "12815074;15336624;17242355;17525332;21183079;21750661;26998601;30084848;34428180;36852467;37507081;8808275", "class_list": "", "function": "Analysis of mHR23A/B double-mutant cells showed that HR23 proteins function in nucleotide excision repair by governing xeroderma pigmentosum group C protein stability via partial protection against proteasomal degradation, [RefSeq, PubMed]; Data demonstrate that sequestration and impairment of nuclear HR23 and nucleocytoplasmic transport proteins is an outcome of, and a contributor to, poly(GA) pathology., [RefSeq, PubMed]; Multifunctional protein that participates in histone H4K20 demethylation, DNA repair, ubiquitin-dependent protein degradation, transcriptional regulation, and viral replication. Specifically demethylates mono-, di- and trimethylated 'Lys-20' of histone H4 (H4K20me1, H4K20me2, H4K20me3, respectively) into unmethylated forms. Activates the transcription of coding genes by demethylating H4K20me1 and the transcription of repetitive elements by demethylating H4K20me3. Involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Involved in nucleotide excision repair, is considered functionally equivalent to RAD23B in global genome nucleotide excision repair (GG-NER) through its association with XPC. In vitro, the XPC-RAD23A complex demonstrates NER activity. Can stabilize XPC., [UniProtKB, PubMed, PubMed]; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B7ZNQ1", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.14.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65", "type": "external" }, { "id": "1.14.99.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0035575 histone H4K20 demethylase activity;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0003684 damaged DNA binding;GO:0019900 kinase binding;GO:1990381 ubiquitin-specific protease binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0006974 DNA damage response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045787 positive regulation of cell cycle;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0031648 protein destabilization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P54726-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SFM8-1", "uniprot_id": [ { "id": "RBM27_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SFM8", "type": "external" } ], "mass": 118552.0, "length": 1060, "protein_name": "RNA-binding protein 27", "gene_name": "Rbm27", "organism": "Mouse", "refseq_name": "RNA-binding protein 27 isoform 2", "refseq_ac": [ { "id": "NP_766214", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766214", "type": "external" } ], "gene_names_uniprotkb": "Rbm27; Kiaa1311", "gene_names_refseq": "A730010I06; Psc1; Rbm27; mKIAA1311", "protein_names_uniprotkb": "RNA-binding protein 27; Peri-implantation stem cell protein 1; RNA-binding motif protein 27", "protein_names_refseq": "RNA-binding protein 27 isoform 2; RNA-binding protein 27; peri implantation stem cell 1; peri-implantation stem cell protein 1; periimplantation stem cell 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:225432); (R-MMU-9930044)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;15741184;21183079;22517741;22645316;29125738;30059200;30084848;31219806;32782141;32848054;34428180;34678516;34887587;35820727;35822049;36852467;39627609;40021952;40885482;40997131", "class_list": "", "function": "May be involved in the turnover of nuclear polyadenylated (pA+) RNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "E9QM85;Q6ZPT9;Q7TQK8;Q8C2X5;Q8C9A5", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q5SFM8-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHN5-1", "uniprot_id": [ { "id": "RBM45_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHN5", "type": "external" } ], "mass": 53324.0, "length": 476, "protein_name": "RNA-binding protein 45", "gene_name": "Rbm45", "organism": "Mouse", "refseq_name": "RNA-binding protein 45", "refseq_ac": [ { "id": "NP_700454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_700454", "type": "external" } ], "gene_names_uniprotkb": "Rbm45; Drb1; Drbp1", "gene_names_refseq": "Drb1; Drbp1; G430095G15Rik; Rbm45", "protein_names_uniprotkb": "RNA-binding protein 45; Developmentally-regulated RNA-binding protein 1; RB-1; RNA-binding motif protein 45", "protein_names_refseq": "RB-1; RNA-binding protein 45; developmentally regulated RNA binding protein 1; dopamine receptor binding 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:241490)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12220514;18782777;21183079;31219806;38040804", "class_list": "", "function": "ARC may protect cardiomyocytes from hypoxic cell death by regulating its downstream, Drbp1 and pMe(2)GlyDH, [RefSeq, PubMed]; RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4., [RefSeq, PubMed]; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1Z5", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BHN5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0F5-1", "uniprot_id": [ { "id": "RBMX2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0F5", "type": "external" } ], "mass": 37536.0, "length": 326, "protein_name": "RNA-binding motif protein, X-linked 2", "gene_name": "Rbmx2", "organism": "Mouse", "refseq_name": "RNA-binding motif protein, X-linked 2", "refseq_ac": [ { "id": "NP_775552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775552", "type": "external" } ], "gene_names_uniprotkb": "Rbmx2", "gene_names_refseq": "2700089A17Rik; 2810411A03Rik; CGI-79; Rbmx2", "protein_names_uniprotkb": "RNA-binding motif protein, X-linked 2", "protein_names_refseq": "RNA-binding motif protein, X-linked 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:209003); (R-MMU-72163)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17242355;21183079", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AF74;Q3TI42", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0031965 nuclear membrane", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R0F5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CW46-1", "uniprot_id": [ { "id": "RAVR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CW46", "type": "external" } ], "mass": 79382.0, "length": 748, "protein_name": "Ribonucleoprotein PTB-binding 1", "gene_name": "Gm38431; Raver1", "organism": "Mouse", "refseq_name": "ribonucleoprotein PTB-binding 1", "refseq_ac": [ { "id": "NP_082187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082187", "type": "external" } ], "gene_names_uniprotkb": "Gm38431; Raver1; Kiaa1978", "gene_names_refseq": "1300006N24Rik; Raver1", "protein_names_uniprotkb": "Ribonucleoprotein PTB-binding 1; Protein raver-1", "protein_names_refseq": "protein raver-1; ribonucleoprotein PTB-binding 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71766)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11724819;14633994;16051233;17096167;18061163;19131326;19144319;21183079;21750661;22872234;25428506;26495903;27802388;30084848;30779550;31219806;31599954;34428180;36210013", "class_list": "", "function": "Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA., [UniProtKB, PubMed]; In mice, raver1 might link gene expression with structural functions of muscle contractility during muscle differentiation., [RefSeq, PubMed]; PTB-mediated splicing repression involves recruitment of raver1 as a potent splicing co-repressor., [RefSeq, PubMed]; Raver1 may play an important role for the regulation of neuronal synaptic plasticity, possibly by controlling especially the late LTP via posttranscriptional mechanisms., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTT6;Q811K0;Q8C3Z1;Q8CA14", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9CW46-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28700-1", "uniprot_id": [ { "id": "RXRA_MOUSE", "url": "https://www.uniprot.org/uniprot/P28700", "type": "external" } ], "mass": 51217.0, "length": 467, "protein_name": "Retinoic acid receptor RXR-alpha", "gene_name": "Rxra", "organism": "Mouse", "refseq_name": "retinoic acid receptor RXR-alpha isoform 1", "refseq_ac": [ { "id": "NP_035435", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035435", "type": "external" } ], "gene_names_uniprotkb": "Rxra; Nr2b1", "gene_names_refseq": "9530071D11Rik; Nr2b1; RXRalpha1; Rxra", "protein_names_uniprotkb": "Retinoic acid receptor RXR-alpha; Nuclear receptor subfamily 2 group B member 1; Retinoid X receptor alpha", "protein_names_refseq": "RXR alpha 1; nuclear receptor subfamily 2 group B member 1; retinoic acid receptor RXR-alpha isoform 1; retinoic acid receptor RXR-alpha", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); alcoholic cardiomyopathy (Disease Ontology:DOID:12935); congenital heart disease (Disease Ontology:DOID:1682); pancreatic cancer (Disease Ontology:DOID:1793); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); prostate carcinoma in situ (Disease Ontology:DOID:8634); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:20181); (R-MMU-159418); (R-MMU-192105); (R-MMU-193368); (R-MMU-193807); (R-MMU-200425); (R-MMU-211976); (R-MMU-381340); (R-MMU-383280); (R-MMU-400206); (R-MMU-4090294); (R-MMU-5362517); (R-MMU-9029569); (R-MMU-9616222); (R-MMU-9623433); (R-MMU-9707564); (R-MMU-9841922)", "pathway_count": 17, "publication_count": 21, "publication_id_list": "10383391;10788465;10882070;12032153;1310259;1312497;15528208;16606617;17595322;20078863;21152046;21183079;21750661;25417649;26463675;30059200;34428180;36210013;38372090;40997131;7838715", "class_list": "", "function": "Inhibition of RXRA-mediated PLA2G2A improves delirium in COPD mice by regulating endoplasmic reticulum stress pathway and inhibiting cell apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for retinoic acid that acts as a transcription factor (PubMed:10383391, PubMed:12032153, PubMed:25417649). Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (PubMed:10383391, PubMed:1310259). The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (PubMed:1310259). The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid (PubMed:10383391, PubMed:25417649). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (By similarity). On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (By similarity). Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA (PubMed:1310259). The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context (By similarity). The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes (By similarity). Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (By similarity). Acts as an enhancer of RARA binding to RARE DNA element (By similarity). May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 (By similarity). Promotes myelin debris phagocytosis and remyelination by macrophages (PubMed:26463675). Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes (PubMed:25417649). Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050693 LBD domain binding;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0030424 axon;GO:0043235 receptor complex", "go_biological_process": "GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P28700-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69Z37-1", "uniprot_id": [ { "id": "SAM9L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69Z37", "type": "external" } ], "mass": 180203.0, "length": 1561, "protein_name": "Sterile alpha motif domain-containing protein 9-like", "gene_name": "Samd9l", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Samd9l; Kiaa2005", "gene_names_refseq": "", "protein_names_uniprotkb": "Sterile alpha motif domain-containing protein 9-like; SAM domain-containing protein 9-like", "protein_names_refseq": "", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); normophosphatemic familial tumoral calcinosis (Disease Ontology:DOID:0080170); autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441)", "pathway": " (mmu:209086)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;24029230;25428506;25428507;30059200;31599954;34428180;40021952", "class_list": "", "function": "May be involved in endosome fusion. Mediates down-regulation of growth factor signaling via internalization of growth factor receptors., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005769 early endosome", "go_biological_process": "GO:0048536 spleen development;GO:0034058 endosomal vesicle fusion;GO:0002244 hematopoietic progenitor cell differentiation;GO:0035726 common myeloid progenitor cell proliferation;GO:0017145 stem cell division", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q69Z37-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z266-1", "uniprot_id": [ { "id": "SNAPN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z266", "type": "external" } ], "mass": 14904.0, "length": 136, "protein_name": "SNARE-associated protein Snapin", "gene_name": "Snapin", "organism": "Mouse", "refseq_name": "SNARE-associated protein Snapin", "refseq_ac": [ { "id": "NP_598615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598615", "type": "external" } ], "gene_names_uniprotkb": "Snapin; Bloc1s7; Snap25bp; Snapap", "gene_names_refseq": "25kDa; Bloc1s7; Snap25bp; Snapap; Snapin", "protein_names_uniprotkb": "SNARE-associated protein Snapin; BLOC-1 subunit 7; Biogenesis of lysosome-related organelles complex 1 subunit 7; SNAP-associated protein; Synaptosomal-associated protein 25-binding protein", "protein_names_refseq": "BLOC-1 subunit 7; SNARE-associated protein Snapin; biogenesis of lysosome-related organelles complex 1 subunit 7; synaptosomal-associated protein 25 binding protein; synaptosomal-associated protein, 25 kDa, binding protein", "tax_id": 10090, "disease": "Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": " (mmu:20615); (R-MMU-432722)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10195194;11283605;12877659;12887314;15102850;16760431;17101137;19168546;19546860;21183079;21750661;21998198;28905875;31219806", "class_list": "", "function": "Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:16760431, PubMed:19546860, PubMed:21998198). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Mutations in the human genes encoding Snapin and the BLOS proteins could underlie novel forms of Hermansky-Pudlak syndrome as seen in mouse models, [RefSeq, PubMed]; Snapin/DAT interaction represents a direct link between exocytotic and reuptake mechanisms., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U8V4;Q922V7", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0000149 SNARE binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0030141 secretory granule;GO:0045202 synapse", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0072553 terminal button organization;GO:0008090 retrograde axonal transport;GO:0006886 intracellular protein transport;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9Z266-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61009-1", "uniprot_id": [ { "id": "SCRB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61009", "type": "external" } ], "mass": 56754.0, "length": 509, "protein_name": "Scavenger receptor class B member 1", "gene_name": "Scarb1", "organism": "Mouse", "refseq_name": "scavenger receptor class B member 1 isoform 2", "refseq_ac": [ { "id": "NP_001192011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192011", "type": "external" } ], "gene_names_uniprotkb": "Scarb1; Srb1", "gene_names_refseq": "CD36; Cd36l1; Chohd1; Cla-1; Cla1; D5Ertd460e; Hdlq1; Hlb398; SR-B1; SR-BI; SRBI; Scarb1; Srb1; mSR-BI", "protein_names_uniprotkb": "Scavenger receptor class B member 1; SR-BI; SRB1", "protein_names_refseq": "HDL QTL 1; scavenger receptor class B member 1 isoform 2; scavenger receptor class B type I; scavenger receptor class B1", "tax_id": 10090, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); sensorineural hearing loss (Disease Ontology:DOID:10003); morbid obesity (Disease Ontology:DOID:11981); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:20778); (R-MMU-3000471); (R-MMU-8964011)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;12429731;21675794;21750661;26495903;26740625;27802388;31219806;34428180;37828378;8560269;9254074;9614139", "class_list": "", "function": "Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (By similarity). Both isoform 1 and isoform 2 act as receptors for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:9254074, PubMed:9614139). Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9452, "biomarker_type": "", "glycan_count": 3, "disease_count": 4, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "D3Z2V4;Q3TZ42;Q4FK30;Q9CWJ7", "ec_number_list": [], "go_molecular_function": "GO:0070506 high-density lipoprotein particle receptor activity;GO:0005044 scavenger receptor activity;GO:0034185 apolipoprotein binding;GO:0042802 identical protein binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0044406 adhesion of symbiont to host;GO:1902070 positive regulation of sphingolipid mediated signaling pathway;GO:0006869 lipid transport;GO:0042311 vasodilation;GO:0015914 phospholipid transport", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q61009-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000100010000.111.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VEA8-1", "uniprot_id": [ { "id": "RAB7B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VEA8", "type": "external" } ], "mass": 22502.0, "length": 199, "protein_name": "Ras-related protein Rab-7b", "gene_name": "Rab7b", "organism": "Mouse", "refseq_name": "ras-related protein Rab-7b isoform 2", "refseq_ac": [ { "id": "NP_001298025", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298025", "type": "external" } ], "gene_names_uniprotkb": "Rab7b; 5430435G22Rik", "gene_names_refseq": "5430435G22Rik; Rab7b", "protein_names_uniprotkb": "Ras-related protein Rab-7b", "protein_names_refseq": "ras-related protein Rab-7b isoform 2; ras-related protein Rab-7b", "tax_id": 10090, "disease": "", "pathway": " (mmu:226421); (R-MMU-8854214); (R-MMU-8873719); (R-MMU-8876198)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "16923123;17395780;19144319;19587007;21750661;32037382;34428180", "class_list": "", "function": "Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway., [UniProtKB, PubMed, PubMed]; Rab7B/42 Is Functionally Involved in Protein Degradation on Melanosomes in Keratinocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0PD09;Q8BJT0;Q8BZB1", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0003925 G protein activity;GO:0003924 GTPase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005764 lysosome;GO:0030670 phagocytic vesicle membrane;GO:0005770 late endosome;GO:0045335 phagocytic vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0032755 positive regulation of interleukin-6 production;GO:0008333 endosome to lysosome transport;GO:0071346 cellular response to type II interferon;GO:0045654 positive regulation of megakaryocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VEA8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99NA2-1", "uniprot_id": [ { "id": "ATOH8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99NA2", "type": "external" } ], "mass": 34785.0, "length": 322, "protein_name": "Transcription factor Atoh8", "gene_name": "Atoh8", "organism": "Mouse", "refseq_name": "transcription factor Atoh8", "refseq_ac": [ { "id": "NP_722473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722473", "type": "external" } ], "gene_names_uniprotkb": "Atoh8; Ath6", "gene_names_refseq": "4933425C05Rik; Atoh8; Hath6; Math6; bHLHa21; okadin", "protein_names_uniprotkb": "Transcription factor Atoh8; Helix-loop-helix protein mATH-6; Okadin; Protein atonal homolog 8; mATH6", "protein_names_refseq": "basic helix-loop-helix transcription factor 6; helix-loop-helix protein mATH-6; protein atonal homolog 8; transcription factor Atoh8", "tax_id": 10090, "disease": "", "pathway": " (mmu:71093)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11733035;16937370;18539898;18560595;21750661;23836893;23938248;24186058;25428506;34402594", "class_list": "", "function": "Bmp6, Smad7, Id1, and Atoh8 transcripts are significantly modulated by the dietary iron content; activation of Smad7, Id1, and Atoh8 transcription by iron requires Smad4., [RefSeq, PubMed]; Math6 may participate in kidney development and may be a permissive factor for podocyte differentiation., [RefSeq, PubMed]; Results demonstrate that Math6 is indispensable for early embryonic development and indicate a more widespread function for this factor in tissue-specific differentiation processes that are dependent on class II bHLH genes Publication Status: Online-Only, [RefSeq, PubMed]; Targeted deletion of Atoh8 results in severe hearing loss in mice., [RefSeq, PubMed]; Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (By similarity). Regulates endothelial cell proliferation, migration and tube-like structures formation (By similarity). Modulates endothelial cell differentiation through NOS3 (By similarity). May be implicated in specification and differentiation of neuronal cell lineages in the brain (PubMed:11733035). May participate in kidney development and may be involved in podocyte differentiation (PubMed:16937370). During early embryonic development is involved in tissue-specific differentiation processes that are dependent on class II bHLH factors and namely modulates the differentiation program initiated by the pro-endocrine factor NEUROG3 (PubMed:18560595). During myogenesis, may play a role during the transition of myoblasts from the proliferative phase to the differentiation phase (PubMed:24186058). Positively regulates HAMP transcription in two ways, firstly by acting directly on the HAMP promoter via E-boxes binding and indirectly through increased phosphorylation of SMAD protein complex (By similarity). Repress NEUROG3-dependent gene activation in a gene-specific manner through at least two mechanisms; requires only either the sequestering of a general partner such as TCF3 through heterodimerization, either also requires binding of the bHLH domain to DNA via a basic motif (PubMed:23938248)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1I7", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0008134 transcription factor binding;GO:0070888 E-box binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99NA2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08997-1", "uniprot_id": [ { "id": "ATOX1_MOUSE", "url": "https://www.uniprot.org/uniprot/O08997", "type": "external" } ], "mass": 7338.0, "length": 68, "protein_name": "Copper transport protein ATOX1", "gene_name": "Atox1", "organism": "Mouse", "refseq_name": "copper transport protein ATOX1", "refseq_ac": [ { "id": "NP_033850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033850", "type": "external" } ], "gene_names_uniprotkb": "Atox1", "gene_names_refseq": "Atox1; Atx1", "protein_names_uniprotkb": "Copper transport protein ATOX1; Metal transport protein ATX1", "protein_names_refseq": "ATX1 (antioxidant protein 1) homolog 1; copper transport protein ATOX1; metal transport protein ATX1", "tax_id": 10090, "disease": "", "pathway": " (mmu:11927); (R-MMU-6803544)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10673341;23806337;28135057;34428180;35315340;36139494;38640584;38796413", "class_list": "", "function": "Atox1 protects hippocampal neurons after traumatic brain injury via DJ-1 mediated anti-oxidative stress and mitophagy., [RefSeq, PubMed]; Atox1 regulates macrophage polarization in intestinal inflammation via ROS-NLRP3 inflammasome pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity)., [UniProtKB]; Copper enhances genotoxic drug resistance via ATOX1 activated DNA damage repair., [RefSeq, PubMed]; Whole-Transcriptome Sequencing Analyses of Nuclear Antixoxidant-1 in Endothelial Cells: Role in Inflammation and Atherosclerosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5NCU2", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding;GO:0005507 copper ion binding;GO:0032767 copper-dependent protein binding;GO:1903136 cuprous ion binding;GO:0016531 copper chaperone activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006878 intracellular copper ion homeostasis;GO:0006979 response to oxidative stress;GO:0043066 negative regulation of apoptotic process;GO:0006825 copper ion transport;GO:0060003 copper ion export", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O08997-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18572-1", "uniprot_id": [ { "id": "BASI_MOUSE", "url": "https://www.uniprot.org/uniprot/P18572", "type": "external" } ], "mass": 42445.0, "length": 389, "protein_name": "Basigin", "gene_name": "Bsg", "organism": "Mouse", "refseq_name": "basigin isoform 2 precursor", "refseq_ac": [ { "id": "NP_001070652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070652", "type": "external" } ], "gene_names_uniprotkb": "Bsg", "gene_names_refseq": "Bsg; CD147; EMMPRIN; HT-7", "protein_names_uniprotkb": "Basigin; Basic immunoglobulin superfamily; HT7 antigen; Membrane glycoprotein gp42", "protein_names_refseq": "5A11/Basigin; HT7 antigen; basic immunoglobulin superfamily; basigin isoform 2 precursor; gp 42; membrane glycoprotein gp42; neurothelin", "tax_id": 10090, "disease": "transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); breast ductal carcinoma (Disease Ontology:DOID:3007); lung squamous cell carcinoma (Disease Ontology:DOID:3907); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); ovary serous adenocarcinoma (Disease Ontology:DOID:5744)", "pathway": " (mmu:12215); (R-MMU-1474228); (R-MMU-210991); (R-MMU-216083); (R-MMU-433692); (R-MMU-9749641)", "pathway_count": 6, "publication_count": 35, "publication_id_list": "10.1101/2023.09.13.557529;10967074;11273674;11853760;11882021;12211060;12558975;12601063;12939332;15037112;15095333;19144319;19349973;19656770;2032306;21750661;21792931;2361961;23727514;25957687;2697642;27057452;27503893;29187734;30899004;34428180;36288343;37158588;37828378;38725999;38824220;39627609;40885482;8333335;8576084", "class_list": "", "function": "CD147 mediates S protein pseudovirus of SARS-CoV-2 infection and its induction of spermatogonia apoptosis., [RefSeq, PubMed]; EMMPRIN promotes spheroid organization and metastatic formation: comparison between monolayers and spheroids of CT26 colon carcinoma cells. Publication Status: Online-Only, [RefSeq, PubMed]; Essential for normal retinal maturation and development (PubMed:10967074, PubMed:11273674, PubMed:11853760). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Plays a role in neurite outgrowth., [UniProtKB, PubMed]; Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (By similarity). Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane (PubMed:12601063). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (By similarity). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells (By similarity). Plays an important role in spermatogenesis; mediates interactions between germ cells and Sertoli cell and is essential for the development/differentiation of germ cells to round spermatids (PubMed:11882021, PubMed:23727514)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 7, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q6LDB0;Q7TSC0", "ec_number_list": [], "go_molecular_function": "GO:0001618 virus receptor activity;GO:0005537 D-mannose binding;GO:0098632 cell-cell adhesion mediator activity;GO:0038023 signaling receptor activity;GO:0140597 protein carrier chaperone", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030424 axon;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1904466 positive regulation of matrix metallopeptidase secretion;GO:0001525 angiogenesis;GO:0003407 neural retina development;GO:0007283 spermatogenesis;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 5.2, "record_id": "P18572-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97477-1", "uniprot_id": [ { "id": "AURKA_MOUSE", "url": "https://www.uniprot.org/uniprot/P97477", "type": "external" } ], "mass": 44772.0, "length": 395, "protein_name": "Aurora kinase A", "gene_name": "Aurka", "organism": "Mouse", "refseq_name": "aurora kinase A isoform b", "refseq_ac": [ { "id": "NP_001278114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278114", "type": "external" } ], "gene_names_uniprotkb": "Aurka; Aik; Airk1; Ark1; Aura; Ayk1; Btak; Iak1; Stk15; Stk6", "gene_names_refseq": "AIRK1; ARK-1; Ark1; Aurka; Aurora-A; Ayk1; IAK1; IAK; Stk6", "protein_names_uniprotkb": "Aurora kinase A; 2.7.11.1; ARK-1; Aurora 2; Aurora-related kinase 1; Aurora/IPL1-related kinase 1; Ipl1- and aurora-related kinase 1; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase Ayk1; Serine/threonine-protein kinase aurora-A", "protein_names_refseq": "aurora 2; aurora A; aurora family kinase 1; aurora kinase A isoform b; aurora-related kinase 1; aurora/IPL1-related kinase 1; ipl1- and aurora-related kinase 1; serine/threonine kinase 6; serine/threonine-protein kinase 15; serine/threonine-protein kinase 6; serine/threonine-protein kinase Ayk1; serine/threonine-protein kinase aurora-A", "tax_id": 10090, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); brain cancer (Disease Ontology:DOID:1319); ovary epithelial cancer (Disease Ontology:DOID:2152); ovarian cancer (Disease Ontology:DOID:2394); endometrial carcinoma (Disease Ontology:DOID:2871); invasive ductal carcinoma (Disease Ontology:DOID:3008); uterine cancer (Disease Ontology:DOID:363); renal cell carcinoma (Disease Ontology:DOID:4450); prostate carcinoma in situ (Disease Ontology:DOID:8634); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:20878); (R-MMU-174178); (R-MMU-2565942); (R-MMU-6804114); (R-MMU-6804756); (R-MMU-8854050); (R-MMU-8854518); (R-MMU-8854521)", "pathway_count": 8, "publication_count": 18, "publication_id_list": "15793587;18579375;18678489;19075002;19668197;20643351;22306998;22753416;23807208;25428506;27753540;31219806;38428643;38442201;38729556;9205101;9245792;9514916", "class_list": "", "function": "EEF1A2 promotes PTEN-GSK3beta-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer., [RefSeq, PubMed]; Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (By similarity). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:19075002, PubMed:9245792). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (By similarity). Required for initial activation of CDK1 at centrosomes (By similarity). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (By similarity). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (By similarity). Regulates KIF2A tubulin depolymerase activity (By similarity). Required for normal axon formation (By similarity). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Important for microtubule formation and/or stabilization (By similarity). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (By similarity). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (By similarity). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; PTEN deficiency induces an extrahepatic cholangitis-cholangiocarcinoma continuum via aurora kinase A in mice., [RefSeq, PubMed]; SOX9 is regulated by AURKA in response to Helicobacter pylori infection via EIF4E-mediated cap-dependent translation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35624;Q8C3H8;Q91YU4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006468 protein phosphorylation;GO:0010629 negative regulation of gene expression;GO:0043066 negative regulation of apoptotic process;GO:0045931 positive regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P97477-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98203-1", "uniprot_id": [ { "id": "ARVC_MOUSE", "url": "https://www.uniprot.org/uniprot/P98203", "type": "external" } ], "mass": 105066.0, "length": 962, "protein_name": "Splicing regulator ARVCF", "gene_name": "Arvcf", "organism": "Mouse", "refseq_name": "splicing regulator ARVCF isoform 1", "refseq_ac": [ { "id": "NP_001258957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258957", "type": "external" } ], "gene_names_uniprotkb": "Arvcf", "gene_names_refseq": "Arvcf", "protein_names_uniprotkb": "Splicing regulator ARVCF; Armadillo repeat protein deleted in velo-cardio-facial syndrome homolog", "protein_names_refseq": "armadillo repeat gene deleted in velo-cardio-facial syndrome; armadillo repeat protein deleted in velo-cardio-facial syndrome homolog; splicing regulator ARVCF isoform 1; splicing regulator ARVCF", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); DiGeorge syndrome (Disease Ontology:DOID:11198)", "pathway": " (mmu:11877)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11058098;15345747;17242355;21183079;21750661;24129315;31219806;34428180;39627609;39927985", "class_list": "", "function": "Contributes to the regulation of alternative splicing of pre-mRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6PGJ6;Q8BQ36;Q8BRF2;Q8C3U7;Q924L2;Q924L3;Q924L4;Q924L5", "ec_number_list": [], "go_molecular_function": "GO:0045296 cadherin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0030054 cell junction", "go_biological_process": "GO:0006397 mRNA processing;GO:0098609 cell-cell adhesion;GO:0008380 RNA splicing;GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P98203-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NVD9-1", "uniprot_id": [ { "id": "BFSP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NVD9", "type": "external" } ], "mass": 45740.0, "length": 416, "protein_name": "Phakinin", "gene_name": "Bfsp2", "organism": "Mouse", "refseq_name": "phakinin isoform 1", "refseq_ac": [ { "id": "NP_001002896", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002896", "type": "external" } ], "gene_names_uniprotkb": "Bfsp2", "gene_names_refseq": "Bfsp2; CP47; CP49; LIFL-L", "protein_names_uniprotkb": "Phakinin; 49 kDa cytoskeletal protein; Beaded filament structural protein 2; CP47; CP49; LIFL-L; Lens fiber cell beaded filament protein CP 47; Lens fiber cell beaded filament protein CP 49; Lens intermediate filament-like light", "protein_names_refseq": "49 kDa cytoskeletal protein; lens fiber cell beaded filament protein CP 47; lens fiber cell beaded filament protein CP 49; lens intermediate filament-like light; phakinin isoform 1; phakinin", "tax_id": 10090, "disease": "cataract 12 multiple types (Disease Ontology:DOID:0110239); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:107993)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12454043;12573667;14985306;15037121;15744838;18178558;19029034;21745462;25428506;27559293;32913386;7679620", "class_list": "", "function": "CP49 and filensin intermediate filaments are essential for formation of cold cataract. Publication Status: Online-Only, [RefSeq, PubMed]; Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (PubMed:15037121, PubMed:27559293). Plays a role in maintenance of retinal lens optical clarity (PubMed:12454043)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63832;Q6P5N4;Q8VDD6", "ec_number_list": [], "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0005882 intermediate filament", "go_biological_process": "GO:0007010 cytoskeleton organization;GO:0007601 visual perception;GO:0045109 intermediate filament organization;GO:0048469 cell maturation;GO:0045104 intermediate filament cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6NVD9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80Y61-1", "uniprot_id": [ { "id": "BI2L2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80Y61", "type": "external" } ], "mass": 58402.0, "length": 522, "protein_name": "BAR/IMD domain-containing adapter protein 2-like 2", "gene_name": "Baiap2l2", "organism": "Mouse", "refseq_name": "BAR/IMD domain-containing adapter protein 2-like 2", "refseq_ac": [ { "id": "NP_808248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808248", "type": "external" } ], "gene_names_uniprotkb": "Baiap2l2", "gene_names_refseq": "Baiap2l2", "protein_names_uniprotkb": "BAR/IMD domain-containing adapter protein 2-like 2; BAI1-associated protein 2-like protein 2; Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2; Pinkbar; Planar intestinal- and kidney-specific BAR domain protein", "protein_names_refseq": "BAI1-associated protein 2-like protein 2; BAR/IMD domain-containing adapter protein 2-like 2; brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2; pinkbar; planar intestinal- and kidney-specific BAR domain protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:207495); (R-MMU-9035034)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21183079;21743456;30084848;33151556;34346063;35044843;36520027;39093051", "class_list": "", "function": "BAIAP2L1 and BAIAP2L2 differently regulate hair cell stereocilia morphology., [RefSeq, PubMed]; BAIAP2L2 is required for the maintenance of mechanotransducing stereocilia of cochlear hair cells., [RefSeq, PubMed]; Ca(2+) entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips., [RefSeq, PubMed]; HNF1beta-associated cyst development and electrolyte disturbances are not explained by BAIAP2L2 expression., [RefSeq, PubMed]; Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness., [RefSeq, PubMed]; Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide., [UniProtKB, PubMed]; Pinkbar, is specifically expressed in intestinal epithelial cells, where it localizes to Rab13-positive vesicles and to the plasma membrane at intercellular junctions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UP58", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0044291 cell-cell contact zone", "go_biological_process": "GO:0007009 plasma membrane organization;GO:0061024 membrane organization;GO:0051017 actin filament bundle assembly;GO:0051764 actin crosslink formation;GO:0030838 positive regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80Y61-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0H7-1", "uniprot_id": [ { "id": "BCL10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0H7", "type": "external" } ], "mass": 25948.0, "length": 233, "protein_name": "B-cell lymphoma/leukemia 10", "gene_name": "Bcl10", "organism": "Mouse", "refseq_name": "B-cell lymphoma/leukemia 10", "refseq_ac": [ { "id": "NP_033870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033870", "type": "external" } ], "gene_names_uniprotkb": "Bcl10; Ciper; Clap", "gene_names_refseq": "BCL-10; Bcl10; CARMEN; CIPER; CLAP; ME10; cE10", "protein_names_uniprotkb": "B-cell lymphoma/leukemia 10; B-cell CLL/lymphoma 10; Bcl-10; CARD-containing molecule enhancing NF-kappa-B; CARD-like apoptotic protein; CED-3/ICH-1 prodomain homologous E10-like regulator; Cellular homolog of vCARMEN; Cellular-E10; Mammalian CARD-containing adapter molecule E10; c-E10; cCARMEN; mCIPER; mCLAP; mE10", "protein_names_refseq": "B-cell CLL/lymphoma 10; B-cell lymphoma/leukemia 10; CARD-containing molecule enhancing NF-kappa-B; CARD-like apoptotic protein; CED-3/ICH-1 prodomain homologous E10-like regulator; cellular homolog of vCARMEN; cellular-E10; mammalian CARD-containing adapter molecule E10", "tax_id": 10090, "disease": "extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (Disease Ontology:DOID:0050909); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); immunodeficiency 37 (Disease Ontology:DOID:0111939); malignant mesothelioma (Disease Ontology:DOID:1790)", "pathway": " (mmu:12042); (R-MMU-1169091); (R-MMU-202424); (R-MMU-2871837); (R-MMU-5607764); (R-MMU-8866654)", "pathway_count": 6, "publication_count": 16, "publication_id_list": "10187770;10187771;10187815;10364242;15213237;22265677;22880103;25428506;28528544;30084848;34014917;34428180;34826258;36115893;36524339;9989495", "class_list": "", "function": "Bcl10 phosphorylation-dependent droplet-like condensation positively regulates DNA virus-induced innate immune signaling., [RefSeq, PubMed]; Keratinocyte-intrinsic BCL10/MALT1 activity initiates and amplifies psoriasiform skin inflammation., [RefSeq, PubMed]; Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PubMed:22265677). Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:22265677). Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (By similarity). This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity). Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity (PubMed:22265677). Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (By similarity). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (By similarity)., [UniProtKB, UniProtKB, PubMed]; Signaling through polymerization and degradation: Analysis and simulations of T cell activation mediated by Bcl10. Publication Status: Online-Only, [RefSeq, PubMed]; Somatosensory neurons express specific sets of lincRNAs, and lincRNA CLAP promotes itch sensation in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBN4", "ec_number_list": [], "go_molecular_function": "GO:0019209 kinase activator activity;GO:0002020 protease binding;GO:0003713 transcription coactivator activity;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045121 membrane raft", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0043065 positive regulation of apoptotic process;GO:0045087 innate immune response;GO:0051260 protein homooligomerization;GO:0006968 cellular defense response", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9Z0H7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41731-1", "uniprot_id": [ { "id": "CD63_MOUSE", "url": "https://www.uniprot.org/uniprot/P41731", "type": "external" } ], "mass": 25767.0, "length": 238, "protein_name": "CD63 antigen", "gene_name": "Cd63", "organism": "Mouse", "refseq_name": "CD63 antigen", "refseq_ac": [ { "id": "NP_001036045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036045", "type": "external" } ], "gene_names_uniprotkb": "Cd63", "gene_names_refseq": "Cd63; ME491; Tspan30", "protein_names_uniprotkb": "CD63 antigen", "protein_names_refseq": "CD63 antigen; melanoma 1 antigen", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); carotid artery disease (Disease Ontology:DOID:3407); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (mmu:12512); (R-MMU-114608); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;19075008;19349973;21041449;21750661;21803846;21962903;23632027;23945142;25428506;26109643;26495903;35820727;8148377", "class_list": "", "function": "Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9393, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031904 endosome lumen", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0010633 negative regulation of epithelial cell migration;GO:0015031 protein transport;GO:0016477 cell migration;GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P41731-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49615-1", "uniprot_id": [ { "id": "CDK5_MOUSE", "url": "https://www.uniprot.org/uniprot/P49615", "type": "external" } ], "mass": 33288.0, "length": 292, "protein_name": "Cyclin-dependent kinase 5", "gene_name": "Cdk5", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 5", "refseq_ac": [ { "id": "NP_031694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031694", "type": "external" } ], "gene_names_uniprotkb": "Cdk5; Cdkn5; Crk6; PSSALRE", "gene_names_refseq": "Cdk5; Crk6", "protein_names_uniprotkb": "Cyclin-dependent kinase 5; 2.7.11.1; Cell division protein kinase 5; Cyclin-dependent-like kinase 5; Serine/threonine-protein kinase PSSALRE; TPKII catalytic subunit; Tau protein kinase II catalytic subunit", "protein_names_refseq": "CR6 protein kinase; TPKII catalytic subunit; cell division protein kinase 5; cyclin-dependent kinase 5; cyclin-dependent-like kinase 5; serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit", "tax_id": 10090, "disease": "lissencephaly (Disease Ontology:DOID:0050453); lissencephaly 7 with cerebellar hypoplasia (Disease Ontology:DOID:0112231); Alzheimer's disease (Disease Ontology:DOID:10652); trigeminal neuralgia (Disease Ontology:DOID:12098); depressive disorder (Disease Ontology:DOID:1596); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (mmu:12568); (R-MMU-180024); (R-MMU-399956); (R-MMU-6804756)", "pathway_count": 4, "publication_count": 30, "publication_id_list": "10896159;11226314;11517264;11955625;12372285;12941275;14586172;16203963;16452087;17143272;19700222;20473298;21210220;21368891;21640796;21750661;23420105;23806337;24235147;24600352;25078650;29511352;33127972;33300544;38772138;39390372;39433564;7490100;7834371;8444355", "class_list": "", "function": "CDK5-USP30 signaling pathway regulates MAVS-mediated inflammation via suppressing mitophagy in MPTP/MPP[+] PD model., [RefSeq, PubMed]; Drp1 acetylation mediated by CDK5-AMPK-GCN5L1 axis promotes cerebral ischemic injury via facilitating mitochondrial fission. Publication Status: Online-Only, [RefSeq, PubMed]; PFKFB3 ameliorates ischemia-induced neuronal damage by reducing reactive oxygen species and inhibiting nuclear translocation of Cdk5. Publication Status: Online-Only, [RefSeq, PubMed]; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Negatively regulates the CACNA1B/CAV2.2 -mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in postmitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Also phosphorylates exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0030547 signaling receptor inhibitor activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation;GO:0006886 intracellular protein transport;GO:0006913 nucleocytoplasmic transport;GO:0006936 muscle contraction", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P49615-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q640L5-1", "uniprot_id": [ { "id": "CCD18_MOUSE", "url": "https://www.uniprot.org/uniprot/Q640L5", "type": "external" } ], "mass": 169741.0, "length": 1455, "protein_name": "Coiled-coil domain-containing protein 18", "gene_name": "Ccdc18", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 18", "refseq_ac": [ { "id": "NP_082757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082757", "type": "external" } ], "gene_names_uniprotkb": "Ccdc18", "gene_names_refseq": "1700021E15Rik; 4932411G06Rik; Ccdc18; NY-SAR-41", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 18", "protein_names_refseq": "coiled-coil domain-containing protein 18; sarcoma antigen NY-SAR-41", "tax_id": 10090, "disease": "", "pathway": " (mmu:73254)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "May promote pre-adipocyte differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BIM9;Q8BIN1;Q9DA43", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0034451 centriolar satellite", "go_biological_process": "GO:1904179 positive regulation of adipose tissue development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q640L5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0D9-1", "uniprot_id": [ { "id": "CEP68_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0D9", "type": "external" } ], "mass": 78749.0, "length": 733, "protein_name": "Centrosomal protein of 68 kDa", "gene_name": "Cep68", "organism": "Mouse", "refseq_name": "centrosomal protein of 68 kDa", "refseq_ac": [ { "id": "NP_758464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758464", "type": "external" } ], "gene_names_uniprotkb": "Cep68", "gene_names_refseq": "6030463E10Rik; Cep68; Kiaa0582", "protein_names_uniprotkb": "Centrosomal protein of 68 kDa; Cep68", "protein_names_refseq": "centrosomal protein of 68 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:216543)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase. Contributes to CROCC/rootletin filament formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3US49;Q5SW85;Q8R2V0", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0030054 cell junction;GO:0034451 centriolar satellite", "go_biological_process": "GO:0007098 centrosome cycle;GO:0010457 centriole-centriole cohesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C0D9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15379-14", "uniprot_id": [ { "id": "CD44_MOUSE", "url": "https://www.uniprot.org/uniprot/P15379", "type": "external" } ], "mass": 85617.0, "length": 778, "protein_name": "CD44 antigen", "gene_name": "Cd44", "organism": "Mouse", "refseq_name": "CD44 antigen isoform c precursor", "refseq_ac": [ { "id": "NP_001034240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034240", "type": "external" } ], "gene_names_uniprotkb": "Cd44; Ly-24", "gene_names_refseq": "Cd44; HERMES; Ly-24; Pgp-1", "protein_names_uniprotkb": "CD44 antigen; ECMR-III; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Hermes antigen; Hyaluronate receptor; Ly-24; Lymphocyte antigen 24; PGP-1; PGP-I; Phagocytic glycoprotein 1; Phagocytic glycoprotein I", "protein_names_refseq": "CD44 antigen isoform c precursor; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; PGP-I; extracellular matrix receptor III; hermes antigen; hyaluronate receptor; lymphocyte antigen 24; phagocytic glycoprotein 1; phagocytic glycoprotein I", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); stroke (Disease Ontology:DOID:0051061); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); cholestasis (Disease Ontology:DOID:13580); nephroblastoma (Disease Ontology:DOID:2154); transitional cell carcinoma (Disease Ontology:DOID:2671); breast ductal carcinoma (Disease Ontology:DOID:3007); invasive ductal carcinoma (Disease Ontology:DOID:3008); invasive lobular carcinoma (Disease Ontology:DOID:3457); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); leiomyomatosis (Disease Ontology:DOID:5138); borna disease (Disease Ontology:DOID:5154); Krukenberg carcinoma (Disease Ontology:DOID:9597)", "pathway": " (mmu:12505); (R-MMU-1474228); (R-MMU-202733); (R-MMU-2142845); (R-MMU-216083); (R-MMU-2160916); (R-MMU-6798695)", "pathway_count": 7, "publication_count": 33, "publication_id_list": "10.1101/2023.09.13.557529;10859330;1469058;17293874;17403031;18250455;18753140;19144319;19893486;21183079;22510880;2403559;24606063;25065622;25428506;25605945;2681416;2682651;29187734;31599954;33649389;34428180;35820727;35984892;37006235;37828378;39627609;39950214;8343954;8464707;8509359;8702806;9472040", "class_list": "glycogene", "function": "Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:25065622, PubMed:8343954). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion. Upon interaction with LGALS9 ligand, activates downstream signaling components including LCK, ERK and MAPK to promotes NK cell activation (PubMed:37006235)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 12, "predicted_n_glycosites": 9, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 16, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "Q05732;Q61395;Q62060;Q62061;Q62062;Q62063;Q62408;Q62409;Q64296;Q99J14;Q9QYX8", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0019901 protein kinase binding;GO:0051219 phosphoprotein binding;GO:0005154 epidermal growth factor receptor binding;GO:0005114 type II transforming growth factor beta receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0002246 wound healing involved in inflammatory response;GO:0006954 inflammatory response;GO:0007155 cell adhesion;GO:0010628 positive regulation of gene expression;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P15379-14", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000011001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11531-1", "uniprot_id": [ { "id": "DMD_MOUSE", "url": "https://www.uniprot.org/uniprot/P11531", "type": "external" } ], "mass": 425832.0, "length": 3678, "protein_name": "Dystrophin", "gene_name": "Dmd", "organism": "Mouse", "refseq_name": "dystrophin isoform 1", "refseq_ac": [ { "id": "NP_031894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031894", "type": "external" } ], "gene_names_uniprotkb": "Dmd", "gene_names_refseq": "DXSmh7; DXSmh9; Dmd; Dp427; Dp71; dys; mdx; pke", "protein_names_uniprotkb": "Dystrophin", "protein_names_refseq": "X-linked muscular dystrophy; dystrophin Dp427-E40e; dystrophin Dp71d(delta71,73-74); dystrophin Dp71f-delta71,74; dystrophin E40e; dystrophin E51b; dystrophin delta-E40e; dystrophin isoform 1", "tax_id": 10090, "disease": "small intestine carcinoid neuroendocrine tumor (Disease Ontology:DOID:0050925); dilated cardiomyopathy 3B (Disease Ontology:DOID:0110461); intellectual disability (Disease Ontology:DOID:1059); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); dilated cardiomyopathy (Disease Ontology:DOID:12930); cognitive disorder (Disease Ontology:DOID:1561); status epilepticus (Disease Ontology:DOID:1824); brain edema (Disease Ontology:DOID:4724); congestive heart failure (Disease Ontology:DOID:6000); muscular atrophy (Disease Ontology:DOID:767); retinal degeneration (Disease Ontology:DOID:8466); Becker muscular dystrophy (Disease Ontology:DOID:9883); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:13405); (R-MMU-390522); (R-MMU-9913351)", "pathway_count": 3, "publication_count": 31, "publication_id_list": "10.1101/2023.09.13.557529;10893187;11430802;11520903;1377655;1543903;1579466;16777071;17242355;19109891;20634290;21183079;21750661;22645316;28498977;31219806;34203471;34428180;35820727;3607877;36288343;3659917;37507081;39927985;40885482;7545544;7547961;7633443;7890770;8111539;9214383", "class_list": "", "function": "Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a large, rod-like cytoskeletal protein which is found at the inner surface of muscle fibers in skeletal and cardiac muscles. The encoded protein, dystrophin, is part of the dystrophin-glycoprotein complex, which bridges the inner cytoskeleton (F-actin) and the extra-cellular matrix. This protein is required for proper development and organization of myofibers as contractile units in striated muscles. Mutations in the human gene cause Duchenne and Becker Muscular Dystrophies and a form of heart disease called DMD-associated dilated cardiomyopathy. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 13, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2A9Z0;O35653;Q60703", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005178 integrin binding;GO:0008270 zinc ion binding;GO:0017022 myosin binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0014904 myotube cell development;GO:0021629 olfactory nerve structural organization;GO:1903409 reactive oxygen species biosynthetic process;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "P11531-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5NCQ5-1", "uniprot_id": [ { "id": "DPH1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5NCQ5", "type": "external" } ], "mass": 48004.0, "length": 438, "protein_name": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 1", "gene_name": "Dph1", "organism": "Mouse", "refseq_name": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 1", "refseq_ac": [ { "id": "NP_652762", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_652762", "type": "external" } ], "gene_names_uniprotkb": "Dph1; Dph2l1; Ovca1", "gene_names_refseq": "2310011M22Rik; 4930488F09Rik; Dph1; Dph2l1; Ovca1", "protein_names_uniprotkb": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; 2.5.1.108; Diphthamide biosynthesis protein 1; Diphtheria toxin resistance protein 1; Ovarian cancer-associated gene 1 protein homolog; S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1", "protein_names_refseq": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; DPH1 homolog; DPH2-like 1; S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1; diphthamide biosynthesis protein 1; diphthamide biosynthesis protein 2 homolog-like 1; diphtheria toxin resistance protein 1; diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1; mmDph1; ovarian cancer-associated gene 1 protein homolog", "tax_id": 10090, "disease": "Miller-Dieker lissencephaly syndrome (Disease Ontology:DOID:0060469); diphthamide deficiency syndrome (Disease Ontology:DOID:0070476); diphthamide deficiency syndrome 1 (Disease Ontology:DOID:0070477)", "pathway": " (mmu:116905); (R-MMU-5358493)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11527402;14744934;15485916;15661533;21183079;21203470;21750661;24895408;25605945;26495903", "class_list": "", "function": "Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:15485916, PubMed:24895408). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Acts as a tumor suppressor (PubMed:14744934, PubMed:15661533, PubMed:24895408)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Ovca1 is a tumor suppressor that can modify p53-induced tumorigenesis and suggest that it acts as a positive regulator for cell cycle progression., [RefSeq, PubMed]; These findings suggest that OVCA1 deficiency in the neural crest contributes to the craniofacial abnormalities in patients with MDS., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80UX6;Q8R445", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.5.1.108", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.108", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0090560 2-(3-amino-3-carboxypropyl)histidine synthase activity;GO:0051536 iron-sulfur cluster binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0030054 cell junction;GO:0048471 perinuclear region of cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0008283 cell population proliferation;GO:0017183 protein histidyl modification to diphthamide", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q5NCQ5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RY04-1", "uniprot_id": [ { "id": "DOCK5_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RY04", "type": "external" } ], "mass": 214429.0, "length": 1868, "protein_name": "Dedicator of cytokinesis protein 5", "gene_name": "Dock5", "organism": "Mouse", "refseq_name": "dedicator of cytokinesis protein 5", "refseq_ac": [ { "id": "NP_808448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808448", "type": "external" } ], "gene_names_uniprotkb": "Dock5; Lr2; Rlc", "gene_names_refseq": "1110060D06Rik; Dock5; E130320D18; lr2; rlc", "protein_names_uniprotkb": "Dedicator of cytokinesis protein 5; Lens rupture protein 2; Rupture of lens cataract protein", "protein_names_refseq": "dedicator of cytokinesis protein 5; lens rupture 2; lens rupture protein 2; rupture of lens cataract protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:68813); (R-MMU-9013149); (R-MMU-9013408); (R-MMU-983231)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;18396277;21183079;22872234;27505886;31219806;31885214;34203471;34428180;38161229;9093026;9230506", "class_list": "", "function": "DOCK5 regulates energy balance and hepatic insulin sensitivity by targeting mTORC1 signaling., [RefSeq, PubMed]; Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism., [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (PubMed:18396277). Together with ELMO1, activates RAC1; the activity is stimulated by RHOG (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QLI4", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0002102 podosome", "go_biological_process": "GO:0016477 cell migration;GO:0016601 Rac protein signal transduction;GO:0046849 bone remodeling;GO:1900026 positive regulation of substrate adhesion-dependent cell spreading;GO:0007520 myoblast fusion", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "B2RY04-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R022-1", "uniprot_id": [ { "id": "DJC12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R022", "type": "external" } ], "mass": 22853.0, "length": 198, "protein_name": "DnaJ homolog subfamily C member 12", "gene_name": "Dnajc12", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily C member 12 isoform 1", "refseq_ac": [ { "id": "NP_038916", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038916", "type": "external" } ], "gene_names_uniprotkb": "Dnajc12; Jdp1", "gene_names_refseq": "Dnajc12; Jdp1; mJDP1", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 12; J domain-containing protein 1", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 12; J domain protein 1; dnaJ homolog subfamily C member 12 isoform 1; dnaJ homolog subfamily C member 12; j domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:30045)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10542335;21183079;21750661;39695187", "class_list": "", "function": "Probable co-chaperone that participates in the proper folding of biopterin-dependent aromatic amino acid hydroxylases, which include phenylalanine-4-hydroxylase (PAH), tyrosine 3-monooxygenase (TH) and peripheral and neuronal tryptophan hydroxylases (TPH1 and TPH2)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9R022-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JMF7-1", "uniprot_id": [ { "id": "DOPP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JMF7", "type": "external" } ], "mass": 27099.0, "length": 238, "protein_name": "Dolichyldiphosphatase 1", "gene_name": "Dolpp1", "organism": "Mouse", "refseq_name": "dolichyldiphosphatase 1 isoform b", "refseq_ac": [ { "id": "NP_001277437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277437", "type": "external" } ], "gene_names_uniprotkb": "Dolpp1", "gene_names_refseq": "0610011H20Rik; Dolpp1; LSFR2", "protein_names_uniprotkb": "Dolichyldiphosphatase 1; 3.6.1.43; Dolichyl pyrophosphate phosphatase 1; Protein 2-23", "protein_names_refseq": "dolichyldiphosphatase 1 isoform b; dolichyldiphosphatase 1; protein 2-23", "tax_id": 10090, "disease": "", "pathway": " (mmu:57170); (R-MMU-446199)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10679242;12198133;21750661;25428506;30084848;40997131", "class_list": "", "function": "Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results support a role for dolichyl pyrophosphate (Dol-P-P) phosphatase (Dolpp1) in the recycling of Dol-P-P discharged during protein N-glycosylation reactions on the luminal leaflet of the endoplasmic reticulum in mammalian cells [Dolpp1]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BN02;Q8R0P7;Q9CRF2", "ec_number_list": [ { "id": "3.6.1.43", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.43", "type": "external" } ], "go_molecular_function": "GO:0047874 dolichyldiphosphatase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JMF7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60904-1", "uniprot_id": [ { "id": "DNJC5_MOUSE", "url": "https://www.uniprot.org/uniprot/P60904", "type": "external" } ], "mass": 22101.0, "length": 198, "protein_name": "DnaJ homolog subfamily C member 5", "gene_name": "Dnajc5", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily C member 5", "refseq_ac": [ { "id": "NP_001258513", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258513", "type": "external" } ], "gene_names_uniprotkb": "Dnajc5; Cspalpha", "gene_names_refseq": "2610314I24Rik; Csp; Dnajc5", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 5; CSP; Cysteine string protein; Cysteine-string protein isoform alpha", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 5; cysteine string protein; dnaJ homolog subfamily C member 5", "tax_id": 10090, "disease": "neuronal ceroid lipofuscinosis 4 (Disease Ontology:DOID:0110720); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503)", "pathway": " (mmu:13002); (R-MMU-6798695); (R-MMU-888590)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "17034881;17208939;17242355;18630941;19131326;19144319;20847230;21183079;21750661;22187053;25253725;25800794;26198635;31219806;32042150;35984892", "class_list": "", "function": "Acts as a co-chaperone for the SNARE protein SNAP-25 (PubMed:22187053). Involved in the calcium-mediated control of a late stage of exocytosis (PubMed:20847230). Acts as a general chaperone in regulated exocytosis (By similarity). May have an important role in presynaptic function (By similarity). May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Point mutations in cysteine string protein-alpha (CSP alpha) cause dominantly inherited adult-onset neuronal ceroid lipofuscinosis (ANCL). Normally palmitoylated cysteine string region of cysteine string protein alpha loses palmitoylation in ANCL mutants., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P54101", "ec_number_list": [], "go_molecular_function": "GO:0043008 ATP-dependent protein binding", "go_cellular_component": "GO:0060203 clathrin-sculpted glutamate transport vesicle membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0043524 negative regulation of neuron apoptotic process;GO:0006457 protein folding;GO:0098693 regulation of synaptic vesicle cycle", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P60904-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55070-1", "uniprot_id": [ { "id": "DNSL3_MOUSE", "url": "https://www.uniprot.org/uniprot/O55070", "type": "external" } ], "mass": 35760.0, "length": 310, "protein_name": "Deoxyribonuclease gamma", "gene_name": "Dnase1l3", "organism": "Mouse", "refseq_name": "deoxyribonuclease gamma precursor", "refseq_ac": [ { "id": "NP_031896", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031896", "type": "external" } ], "gene_names_uniprotkb": "Dnase1l3", "gene_names_refseq": "DNasegamma; Dhp2; Dnase1l3; Lsd", "protein_names_uniprotkb": "Deoxyribonuclease gamma; 3.1.21.-; DNase I homolog protein DHP2; DNase I-like 3; DNase gamma; Deoxyribonuclease I-like 3; LS-DNase; LSD; Liver and spleen DNase", "protein_names_refseq": "DNase I homolog protein DHP2; DNase I-like 3; DNase gamma; LS-DNase; deoxyribonuclease I-like 3; deoxyribonuclease gamma precursor; deoxyribonuclease gamma; liver and spleen DNase; macrophage specific DNase I", "tax_id": 10090, "disease": "", "pathway": " (mmu:13421)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10807908;12050166;12095301;12974753;15167901;15796714;17218958;19154352;24312463;26495903;26740625;27293190;28011936;29191910;31219806;32152506;34428180;38744839;38888971;9714828", "class_list": "", "function": "A comparison of the expression and transport of DNAse1 from rats and DNAse1L3 from mice is reported., [RefSeq, PubMed]; A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and death in genetic and induced lupus models. Publication Status: Online-Only, [RefSeq, PubMed]; Double-negative B cells and DNASE1L3 colocalise with microbiota in gut-associated lymphoid tissue. Publication Status: Online-Only, [RefSeq, PubMed]; Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends (By similarity). Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA (PubMed:12095301, PubMed:15796714, PubMed:19154352). Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells (PubMed:12050166, PubMed:15167901, PubMed:17218958, PubMed:24312463). Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity (PubMed:15796714, PubMed:27293190). Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs) (PubMed:29191910). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:29191910). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (PubMed:29191910)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Serum contains two nucleases, DNase1 and DNase1l3, which may substitute or cooperate with each other during DNA degradation, providing effective clearance after exposure or release from dying cells., [RefSeq, PubMed]; These results suggest that DNasegamma provides an alternative mechanism for inducing nuclear changes when the working apoptotic cascade is unsuitable for caspase-activated DNase activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91X38", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0004519 endonuclease activity;GO:0004520 DNA endonuclease activity;GO:0004530 deoxyribonuclease I activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0002283 neutrophil activation involved in immune response;GO:0070948 regulation of neutrophil mediated cytotoxicity;GO:0006309 apoptotic DNA fragmentation;GO:0006308 DNA catabolic process;GO:0010623 programmed cell death involved in cell development", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "O55070-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70396-1", "uniprot_id": [ { "id": "DLX5_MOUSE", "url": "https://www.uniprot.org/uniprot/P70396", "type": "external" } ], "mass": 31396.0, "length": 289, "protein_name": "Homeobox protein DLX-5", "gene_name": "Dlx5", "organism": "Mouse", "refseq_name": "homeobox protein DLX-5 isoform 1", "refseq_ac": [ { "id": "NP_034186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034186", "type": "external" } ], "gene_names_uniprotkb": "Dlx5", "gene_names_refseq": "Dlx5", "protein_names_uniprotkb": "Homeobox protein DLX-5", "protein_names_refseq": "homeobox protein DLX-5 isoform 1; homeobox protein DLX-5", "tax_id": 10090, "disease": "split hand-foot malformation 1 (Disease Ontology:DOID:0090021); split hand-foot malformation 1 with sensorineural hearing loss (Disease Ontology:DOID:0090024)", "pathway": " (mmu:13395)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10075846;15383550;18056716;19393622;19956613;8855272;9415433;9763476", "class_list": "", "function": "Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O54876;O54877;O54878;Q9JJ45", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007409 axonogenesis;GO:0008283 cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P70396-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJ42-1", "uniprot_id": [ { "id": "DLGP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJ42", "type": "external" } ], "mass": 119074.0, "length": 1059, "protein_name": "Disks large-associated protein 2", "gene_name": "Dlgap2", "organism": "Mouse", "refseq_name": "disks large-associated protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001139437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139437", "type": "external" } ], "gene_names_uniprotkb": "Dlgap2; Dap2", "gene_names_refseq": "6430596N04Rik; Dap-2; Dap2; Dlgap2; Sapap2", "protein_names_uniprotkb": "Disks large-associated protein 2; DAP-2; PSD-95/SAP90-binding protein 2; SAP90/PSD-95-associated protein 2; SAPAP2", "protein_names_refseq": "PSD-95/SAP90-binding protein 2; SAP90/PSD-95 associated protein 2; discs, large homolog-associated protein 2; disks large-associated protein 2 isoform 2; disks large-associated protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:244310); (R-MMU-6794361)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;15024750;16452087;19640847;21183079;22517741;22645316;31745236;32848054;33300544;33347690;35822049;36169576;40885482", "class_list": "", "function": "Altered synaptic protein expression, aberrant spine morphology, and impaired spatial memory in Dlgap2 mutant mice, a genetic model of autism spectrum disorder., [RefSeq, PubMed]; Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence., [RefSeq, PubMed]; Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2., [RefSeq, PubMed]; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane., [UniProtKB]; Semi-quantitative analysis of RNA levels in FMRP immunoprecipitates showed that in the mouse brain mRNAs encoding PSD components, such as Shank1, SAPAP1-3, PSD-95, and the glutamate receptor subunits NR1 and NR2B, are associated with FMRP., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q6XBF3", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043197 dendritic spine;GO:0099092 postsynaptic density, intracellular component", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission;GO:0023052 signaling", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q8BJ42-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3H0-1", "uniprot_id": [ { "id": "DP13A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K3H0", "type": "external" } ], "mass": 79328.0, "length": 707, "protein_name": "DCC-interacting protein 13-alpha", "gene_name": "Appl1", "organism": "Mouse", "refseq_name": "DCC-interacting protein 13-alpha", "refseq_ac": [ { "id": "NP_660256", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660256", "type": "external" } ], "gene_names_uniprotkb": "Appl1; Dip13a; Kiaa1428", "gene_names_refseq": "2900057D21Rik; 7330406P05Rik; Appl1; DIP13", "protein_names_uniprotkb": "DCC-interacting protein 13-alpha; Adapter protein containing PH domain, PTB domain and leucine zipper motif 1; Dip13-alpha", "protein_names_refseq": "DCC-interacting protein 13-alpha; DIP13 alpha; adapter protein containing PH domain, PTB domain and leucine zipper motif 1; adaptor protein APPL like; dip13-alpha", "tax_id": 10090, "disease": "maturity-onset diabetes of the young type 14 (Disease Ontology:DOID:0111111)", "pathway": " (mmu:72993); (R-MMU-418889)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "15345747;16622416;17242355;19661063;20133602;21183079;21849472;24025512;24813896;25328665;25428506;25568335;26445298;26495903;27219021;30084848;31599954;34428180;34789781;35984564;36842495;37795615;39627609", "class_list": "", "function": "APPL1 interacts with adiponectin receptors in mammalian cells and the interaction is stimulated by adiponectin. Erratum:[Nat Cell Biol. 2006 Jun;8(6):642], [RefSeq, PubMed]; Dysfunctional APPL1-Mediated Epigenetic Regulation in Diabetic Vascular Injury. Erratum:[Arterioscler Thromb Vasc Biol. 2024 May;44(5):e171. doi: 10.1161/ATV.0000000000000171. PMID: 38657036], [RefSeq, PubMed]; Impairment of APPL1/Myoferlin facilitates adipogenic differentiation of mesenchymal stem cells by blocking autophagy flux in osteoporosis. Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (By similarity) (PubMed:25328665, PubMed:25568335, PubMed:27219021). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (By similarity). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (PubMed:25328665). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (PubMed:25568335). Regulates TLR4 signaling in activated macrophages (PubMed:27219021). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner. Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (By similarity). Required for fibroblast migration through HGF cell signaling (PubMed:26445298). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; NMDA Receptor-Dependent Synaptic Potentiation via APPL1 Signaling Is Required for the Accessibility of a Prefrontal Neuronal Assembly in Retrieving Fear Extinction., [RefSeq, PubMed]; The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJP7;Q69ZJ9;Q8BWZ8;Q8VCJ8;Q9CUW4", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0044877 protein-containing complex binding;GO:0001786 phosphatidylserine binding;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0097708 intracellular vesicle;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0010762 regulation of fibroblast migration;GO:0046324 regulation of D-glucose import;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0099558 maintenance of synapse structure;GO:0033211 adiponectin-activated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q8K3H0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERC8-1", "uniprot_id": [ { "id": "DSCAM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERC8", "type": "external" } ], "mass": 222268.0, "length": 2013, "protein_name": "Cell adhesion molecule DSCAM", "gene_name": "Dscam", "organism": "Mouse", "refseq_name": "cell adhesion molecule DSCAM precursor", "refseq_ac": [ { "id": "NP_112451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112451", "type": "external" } ], "gene_names_uniprotkb": "Dscam", "gene_names_refseq": "4932410A21Rik; Dscam", "protein_names_uniprotkb": "Cell adhesion molecule DSCAM; Down syndrome cell adhesion molecule homolog", "protein_names_refseq": "Down syndrome cell adhesion molecule homolog; cell adhesion molecule DSCAM precursor; cell adhesion molecule DSCAM", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (mmu:13508); (R-MMU-376172)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11237714;11856873;15169762;18216855;18585357;19196994;19945391;21750661;22685302;25428506;30059200;31599954;37079499;38302444", "class_list": "", "function": "Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:18216855, PubMed:19196994, PubMed:19945391). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC (PubMed:18585357). Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC (PubMed:22685302). In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38. Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]; DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models. Publication Status: Online-Only, [RefSeq, PubMed]; Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann glia for functional synapse formation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 13, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 13, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 13, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 2, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity;GO:1990782 protein tyrosine kinase binding;GO:1990890 netrin receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0030426 growth cone;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0007626 locomotory behavior;GO:0035249 synaptic transmission, glutamatergic;GO:0007417 central nervous system development;GO:0007416 synapse assembly", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "Q9ERC8-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYI5-3", "uniprot_id": [ { "id": "DNJB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYI5", "type": "external" } ], "mass": 35593.0, "length": 324, "protein_name": "DnaJ homolog subfamily B member 2", "gene_name": "Dnajb2", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily B member 2 isoform 3", "refseq_ac": [ { "id": "NP_001153355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153355", "type": "external" } ], "gene_names_uniprotkb": "Dnajb2; Dnajb10", "gene_names_refseq": "2700059H22Rik; Dnajb10; Dnajb2; Hsj1; mDj8", "protein_names_uniprotkb": "DnaJ homolog subfamily B member 2; DnaJ homolog subfamily B member 10; mDj8", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 10; DnaJ (Hsp40) homolog, subfamily B, member 2; dnaJ homolog subfamily B member 10; dnaJ homolog subfamily B member 2 isoform 3; dnaJ homolog subfamily B member 2; heat shock protein, DNAJ-like 1", "tax_id": 10090, "disease": "autosomal dominant limb-girdle muscular dystrophy type 1 (Disease Ontology:DOID:0110305); autosomal recessive distal hereditary motor neuronopathy 5 (Disease Ontology:DOID:0111214)", "pathway": " (mmu:56812)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11147971;16452087;16604191;20395441;21183079;21832061", "class_list": "", "function": "Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase, [RefSeq, PubMed]; Data show that DNAJB2 is expressed in skeletal muscle at the neuromuscular junction of normal fibers, in the cytoplasm and membrane of regenerating fibers, and in protein aggregates and vacuoles in protein aggregate myopathies., [RefSeq, PubMed]; Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family. In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins. Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes. Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins., [UniProtKB, UniProtKB]; Hsc70, Hdj1 and Hdj2 interact with soluble and fibrillar alpha-synuclein, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TB24;Q8BPF6;Q921S2", "ec_number_list": [], "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0090084 negative regulation of inclusion body assembly;GO:0008285 negative regulation of cell population proliferation;GO:0032880 regulation of protein localization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9QYI5-3", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYJ0-1", "uniprot_id": [ { "id": "DNJA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYJ0", "type": "external" } ], "mass": 45746.0, "length": 412, "protein_name": "DnaJ homolog subfamily A member 2", "gene_name": "Dnaja2", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily A member 2", "refseq_ac": [ { "id": "NP_062768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062768", "type": "external" } ], "gene_names_uniprotkb": "Dnaja2", "gene_names_refseq": "1500017M13Rik; 2010206B19Rik; DNAJ; DNJ3; Dnaj3; Dnaja2; HIRIP4; PRO3015; mDj3", "protein_names_uniprotkb": "DnaJ homolog subfamily A member 2; mDj3", "protein_names_refseq": "DNA J protein; DnaJ (Hsp40) homolog, subfamily A, member 2; dnaJ homolog subfamily A member 2", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); liver disease (Disease Ontology:DOID:409)", "pathway": " (mmu:56445); (R-MMU-3371497)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11147971;18595009;23806337;25605945;30084848;30779550;33300544;34428180;37507081;37828378;39927985", "class_list": "", "function": "Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro)., [UniProtKB, UniProtKB]; Rdj2 modulates G protein signaling and further suggest that chaperoning G proteins is an emerging theme of the J protein network., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0034605 cellular response to heat;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9QYJ0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42125-1", "uniprot_id": [ { "id": "ECI1_MOUSE", "url": "https://www.uniprot.org/uniprot/P42125", "type": "external" } ], "mass": 32250.0, "length": 289, "protein_name": "Enoyl-CoA delta isomerase 1, mitochondrial", "gene_name": "Eci1", "organism": "Mouse", "refseq_name": "enoyl-CoA delta isomerase 1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_034153", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034153", "type": "external" } ], "gene_names_uniprotkb": "Eci1; Dci", "gene_names_refseq": "Dci; Eci1; eci", "protein_names_uniprotkb": "Enoyl-CoA delta isomerase 1, mitochondrial; 3,2-trans-enoyl-CoA isomerase; 5.3.3.8; D3,D2-enoyl-CoA isomerase; Delta(3),Delta(2)-enoyl-CoA isomerase; Dodecenoyl-CoA isomerase", "protein_names_refseq": "3,2 trans-enoyl-Coenyme A isomerase; 3,2-trans-enoyl-CoA isomerase, mitochondrial; D3,D2-enoyl-CoA isomerase; delta(3),Delta(2)-enoyl-CoA isomerase; dodecenoyl-CoA isomerase; dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenyme A isomerase); enoyl-CoA delta isomerase 1, mitochondrial precursor; enoyl-CoA delta isomerase 1, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:13177); (R-MMU-77288); (R-MMU-9837999)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "21750661;23576753;23806337;24682920;29187734;34428180;36288343;37453647;37507081;39927985;8224148", "class_list": "", "function": "Auxiliary enzyme in the beta-oxidation of mono- and polyunsaturated fatty acids. Together with the 2,4-dienoyl-CoA reductase (DECR) and the Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase (ECH1), they allow the reentrance of the enoyl-CoA into the beta-oxidation cycle. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of fatty enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs (By similarity). The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length, and based on its established catalytic mechanism, it is predicted to act also on other fatty acids besides those tested experimentally (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Data indicate that diets enriched with safflower oil induce markedly increased hepatic Delta(3)Delta(2)-enoyl-CoA isomerase (ECI)activities in the liver., [RefSeq, PubMed]; Key enzyme of fatty acid beta-oxidation. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8QZV3", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004165 delta(3)-delta(2)-enoyl-CoA isomerase activity;GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P42125-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TZW0-1", "uniprot_id": [ { "id": "ECSCR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TZW0", "type": "external" } ], "mass": 22689.0, "length": 214, "protein_name": "Endothelial cell-specific chemotaxis regulator", "gene_name": "Ecscr", "organism": "Mouse", "refseq_name": "endothelial cell-specific chemotaxis regulator isoform 3", "refseq_ac": [ { "id": "NP_001028313", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028313", "type": "external" } ], "gene_names_uniprotkb": "Ecscr; Ecsm2", "gene_names_refseq": "1110006O17Rik; ARIA; Ecscr", "protein_names_uniprotkb": "Endothelial cell-specific chemotaxis regulator; ARIA; Apoptosis regulator through modulating IAP expression; Endothelial cell-specific molecule 2", "protein_names_refseq": "apoptosis regulator through modulating IAP expression; endothelial cell-specific chemotaxis regulator isoform 3; endothelial cell-specific chemotaxis regulator; endothelial cell-specific molecule 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68545)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19416853;21183079;21750661;22606020", "class_list": "", "function": "ARIA was expressed in blood vessels during mouse embryogenesis, as well as in endothelial cells both in vitro and in vivo., [RefSeq, PubMed]; Regulates endothelial chemotaxis and tube formation (By similarity). Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2., [UniProtKB, PubMed]; Two mouse ECSCR splicing variants/isoform precursors exist and are differentially expressed in a variety of tissue types and likely involved in modulation of vascular Endothelial cell migration., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "C3RSF3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0006935 chemotaxis;GO:0030154 cell differentiation;GO:0006915 apoptotic process;GO:0016525 negative regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3TZW0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BUR4-1", "uniprot_id": [ { "id": "DOCK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BUR4", "type": "external" } ], "mass": 215085.0, "length": 1865, "protein_name": "Dedicator of cytokinesis protein 1", "gene_name": "Dock1", "organism": "Mouse", "refseq_name": "dedicator of cytokinesis protein 1", "refseq_ac": [ { "id": "NP_001028592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028592", "type": "external" } ], "gene_names_uniprotkb": "Dock1", "gene_names_refseq": "9130006G06Rik; D630004B07Rik; Dock1; b2b3190Clo", "protein_names_uniprotkb": "Dedicator of cytokinesis protein 1; 180 kDa protein downstream of CRK; DOCK180", "protein_names_refseq": "180 kDa protein downstream of CRK; DOCK180; dedicator of cyto-kinesis 1; dedicator of cytokinesis protein 1", "tax_id": 10090, "disease": "DiGeorge syndrome (Disease Ontology:DOID:11198); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (mmu:330662); (R-MMU-2029482); (R-MMU-418885); (R-MMU-4420097); (R-MMU-8849471); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013408); (R-MMU-983231); (R-MMU-9958810)", "pathway_count": 10, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;17960134;21183079;21750661;22080864;25118935;25428506;25468898;25533347;30084848;31219806;34428180;35778533;9733740", "class_list": "", "function": "Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML., [RefSeq, PubMed]; Inactivation of Dock1 in mammary gland epithelial cells and activation of Stat3 coincide with a delay in the initiation of mammary gland involution. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3URT8;Q3UY80;Q4QQL8;Q6PD14;Q8BVC9;Q91Z55;Q922V1", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098794 postsynapse;GO:0032045 guanyl-nucleotide exchange factor complex", "go_biological_process": "GO:0016477 cell migration;GO:0006909 phagocytosis;GO:0006915 apoptotic process;GO:0007264 small GTPase-mediated signal transduction;GO:1900026 positive regulation of substrate adhesion-dependent cell spreading", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8BUR4-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDY4-1", "uniprot_id": [ { "id": "EFCB7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDY4", "type": "external" } ], "mass": 71442.0, "length": 628, "protein_name": "EF-hand calcium-binding domain-containing protein 7", "gene_name": "Efcab7", "organism": "Mouse", "refseq_name": "EF-hand calcium-binding domain-containing protein 7", "refseq_ac": [ { "id": "NP_663524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663524", "type": "external" } ], "gene_names_uniprotkb": "Efcab7; Kiaa1799", "gene_names_refseq": "Efcab7; mKIAA1799", "protein_names_uniprotkb": "EF-hand calcium-binding domain-containing protein 7", "protein_names_refseq": "EF-hand calcium-binding domain-containing protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:230500)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;24582806", "class_list": "", "function": "Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (PubMed:24582806). Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia (PubMed:24582806)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQS0;Q5DTU8", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0009898 cytoplasmic side of plasma membrane;GO:0060170 ciliary membrane;GO:0098797 plasma membrane protein complex;GO:0016020 membrane", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008589 regulation of smoothened signaling pathway;GO:1903569 positive regulation of protein localization to ciliary membrane;GO:0120229 protein localization to motile cilium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VDY4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8N0-1", "uniprot_id": [ { "id": "EF1G_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8N0", "type": "external" } ], "mass": 50061.0, "length": 437, "protein_name": "Elongation factor 1-gamma", "gene_name": "Eef1g", "organism": "Mouse", "refseq_name": "elongation factor 1-gamma", "refseq_ac": [ { "id": "NP_080283", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080283", "type": "external" } ], "gene_names_uniprotkb": "Eef1g", "gene_names_refseq": "2610301D06Rik; EF1G; Eef1g", "protein_names_uniprotkb": "Elongation factor 1-gamma; EF-1-gamma; eEF-1B gamma", "protein_names_refseq": "EF-1-gamma; eEF-1B gamma; elongation factor 1-gamma", "tax_id": 10090, "disease": "", "pathway": " (mmu:67160); (R-MMU-156842)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;21540332;22645316;23806337;24788674;25428506;25605945;26495903;28011936;29187734;30084848;31219806;31599954;33725478;34428180;36210013;36288343;37453647;37507081;37828378;39627609;39927985;40684658", "class_list": "glycogene", "function": "Probably plays a role in anchoring the complex to other cellular components., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 10, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q920C5;Q9CRT5;Q9CSU3;Q9D004", "ec_number_list": [], "go_molecular_function": "GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0009615 response to virus;GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q9D8N0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10126-1", "uniprot_id": [ { "id": "EF1A1_MOUSE", "url": "https://www.uniprot.org/uniprot/P10126", "type": "external" } ], "mass": 50114.0, "length": 462, "protein_name": "Elongation factor 1-alpha 1", "gene_name": "Eef1a1", "organism": "Mouse", "refseq_name": "elongation factor 1-alpha 1", "refseq_ac": [ { "id": "NP_034236", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034236", "type": "external" } ], "gene_names_uniprotkb": "Eef1a1; Eef1a", "gene_names_refseq": "Eef1a1", "protein_names_uniprotkb": "Elongation factor 1-alpha 1; 3.6.5.-; EF-1-alpha-1; EF-Tu; Elongation factor Tu; Eukaryotic elongation factor 1 A-1; eEF1A-1", "protein_names_refseq": "EF-1-alpha-1; EF-Tu; eEF1A-1; elongation factor 1 A-1; elongation factor 1-alpha 1; elongation factor Tu; eukaryotic elongation factor 1 A-1", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 33 (Disease Ontology:DOID:0080463); dilated cardiomyopathy (Disease Ontology:DOID:12930); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:13627); (R-MMU-156842); (R-MMU-3371511); (R-MMU-6798695); (R-MMU-8876725)", "pathway_count": 5, "publication_count": 40, "publication_id_list": "10.1101/2023.09.13.557529;16075062;16139798;17322886;19856081;21540332;21750661;22645316;22872234;23806337;25428506;25605945;2569467;26495903;26740625;28011936;28108655;2911475;30084848;31219806;32152506;3215517;33300544;33725478;34203471;34428180;3481036;34887587;35820727;35984892;36210013;36288343;37453647;37507081;37828378;39339978;39349455;3960725;39627609;39927985", "class_list": "", "function": "N-Acetylcysteine Inhibits Coxsackievirus B3 Replication by Downregulating Eukaryotic Translation Elongation Factor 1 Alpha 1. Publication Status: Online-Only, [RefSeq, PubMed]; Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome. The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation. Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (By similarity). Also plays a role in cytoskeleton organization by promoting actin bundling., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q61511;Q6ZWN2;Q8BMB8;Q8BVS8;Q99KU5", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0019209 kinase activator activity;GO:0060090 molecular adaptor activity;GO:0003729 mRNA binding;GO:0003924 GTPase activity;GO:0005516 calmodulin binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006412 translation;GO:0071364 cellular response to epidermal growth factor stimulus;GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "P10126-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54908-1", "uniprot_id": [ { "id": "DKK1_MOUSE", "url": "https://www.uniprot.org/uniprot/O54908", "type": "external" } ], "mass": 29298.0, "length": 272, "protein_name": "Dickkopf-related protein 1", "gene_name": "Dkk1", "organism": "Mouse", "refseq_name": "dickkopf-related protein 1 precursor", "refseq_ac": [ { "id": "NP_034181", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034181", "type": "external" } ], "gene_names_uniprotkb": "Dkk1", "gene_names_refseq": "Dkk1; mdkk-1", "protein_names_uniprotkb": "Dickkopf-related protein 1; Dickkopf-1; Dkk-1; mDkk-1", "protein_names_refseq": "dickkopf homolog 1; dickkopf-1; dickkopf-like protein 1; dickkopf-related protein 1 precursor; dickkopf-related protein 1; dkk-1", "tax_id": 10090, "disease": "anodontia (Disease Ontology:DOID:13714)", "pathway": " (mmu:13380); (R-MMU-3772470)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "17143291;18505822;18524778;26206087;27550540;9450748", "class_list": "", "function": "Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:18524778). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (PubMed:26206087). Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning (PubMed:18505822)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80UL5", "ec_number_list": [], "go_molecular_function": "GO:0050750 low-density lipoprotein particle receptor binding;GO:0048019 receptor antagonist activity;GO:0039706 co-receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0060323 head morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007611 learning or memory;GO:0010628 positive regulation of gene expression;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O54908-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811T9-1", "uniprot_id": [ { "id": "DISC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q811T9", "type": "external" } ], "mass": 92525.0, "length": 852, "protein_name": "Disrupted in schizophrenia 1 homolog", "gene_name": "Disc1", "organism": "Mouse", "refseq_name": "disrupted in schizophrenia 1 homolog isoform 2", "refseq_ac": [ { "id": "NP_777278", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777278", "type": "external" } ], "gene_names_uniprotkb": "Disc1", "gene_names_refseq": "Disc1", "protein_names_uniprotkb": "Disrupted in schizophrenia 1 homolog", "protein_names_refseq": "disrupted in schizophrenia 1 homolog isoform 2; disrupted in schizophrenia 1 homolog", "tax_id": 10090, "disease": "Asperger syndrome (Disease Ontology:DOID:0050432); schizophrenia 9 (Disease Ontology:DOID:0070085); autistic disorder (Disease Ontology:DOID:12849); major depressive disorder (Disease Ontology:DOID:1470); melancholic depression (Disease Ontology:DOID:1595); psychotic disorder (Disease Ontology:DOID:2468); substance-related disorder (Disease Ontology:DOID:303); bipolar disorder (Disease Ontology:DOID:3312); schizophrenia (Disease Ontology:DOID:5419); chronic fatigue syndrome (Disease Ontology:DOID:8544)", "pathway": " (mmu:244667)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "12504857;12506198;12573262;14960334;14962739;15797709;17825401;19303846;19502360;19778506;20956536;21471969;22072671;31444471;31599954", "class_list": "", "function": "DISC1 interacts with Nudel through a leucine zipper domain and binds to a novel DISC1-interaction domain on Nudel, which is independent from the Lis1 binding site., [RefSeq, PubMed]; Disc1 marks the hippocampus from its earliest stages, and developmental Disc1 dysfunction may lead to defects in hippocampal function that are associated with schizophrenia., [RefSeq, PubMed]; Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:17825401, PubMed:19502360, PubMed:31444471). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus (PubMed:17825401, PubMed:19502360). Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance (PubMed:19303846). Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation (PubMed:19778506). Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A (PubMed:19778506). Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development (PubMed:19502360). Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (PubMed:31444471). Plays a role, together with PCNT, in the microtubule network formation (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; The amino acid sequence of DISC1 is diverging rapidly, although a putative nuclear localization signal and discrete blocks of coiled coil are specifically conserved features, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQ21;Q8CF87;Q8CF88;Q8CHP1;Q8CHP2", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0019894 kinesin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0021799 cerebral cortex radially oriented cell migration;GO:0007399 nervous system development;GO:0010976 positive regulation of neuron projection development;GO:0001764 neuron migration;GO:0050965 detection of temperature stimulus involved in sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q811T9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80UW2-1", "uniprot_id": [ { "id": "FBX2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80UW2", "type": "external" } ], "mass": 33676.0, "length": 297, "protein_name": "F-box only protein 2", "gene_name": "Fbxo2", "organism": "Mouse", "refseq_name": "F-box only protein 2", "refseq_ac": [ { "id": "NP_789818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789818", "type": "external" } ], "gene_names_uniprotkb": "Fbxo2; Fbs1; Fbx2", "gene_names_refseq": "FBG1; FBX2; Fbs1; Fbs2; Fbxo2; NFB42; Prpl4", "protein_names_uniprotkb": "F-box only protein 2", "protein_names_refseq": "F-box only protein 2; prion protein ligand 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:230904); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;0;12140560;14990996;15723043;15809437;17215248;17389369;17494702;17720138;21183079;33300544;36982617", "class_list": "glycogene", "function": "Sleeve Gastrectomy Improves Hepatic Glucose Metabolism by Downregulating FBXO2 and Activating the PI3K-AKT Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; When expressed in hippocampal neurons, the Fbx2 dominant-negative mutant augmented NR1 subunit levels and NMDA receptor-mediated currents in an activity-dependent fashion, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0D2", "ec_number_list": [], "go_molecular_function": "GO:0031249 denatured protein binding;GO:0001540 amyloid-beta binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098890 extrinsic component of postsynaptic membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043197 dendritic spine", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:0031396 regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q80UW2-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JI78-1", "uniprot_id": [ { "id": "NGLY1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JI78", "type": "external" } ], "mass": 74275.0, "length": 651, "protein_name": "Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase", "gene_name": "Ngly1", "organism": "Mouse", "refseq_name": "peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform 1", "refseq_ac": [ { "id": "NP_067479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067479", "type": "external" } ], "gene_names_uniprotkb": "Ngly1", "gene_names_refseq": "1110002C09Rik; Ngly1; PNGase; Png1", "protein_names_uniprotkb": "Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; 3.5.1.52; N-glycanase 1; PNGase; Peptide:N-glycanase; mPNGase", "protein_names_refseq": "peptide N-glycanase homolog; peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform 1; peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase", "tax_id": 10090, "disease": "congenital disorder of deglycosylation 1 (Disease Ontology:DOID:0060728); congenital disorder of deglycosylation (Disease Ontology:DOID:0060991)", "pathway": " (mmu:59007); (R-MMU-532668)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10831608;11562482;12606569;12711318;15358861;15610852;16055502;16249333;16500903;16709668;20173027;21750661;2513186;25428506;26495903;30084848;30779550;34215698;34428180;36209585;38139429;8021270", "class_list": "glycogene", "function": "Comparative proteomics reveals elevated CCN2 in NGLY1-deficient cells., [RefSeq, PubMed]; Data show that both the yeast PNG1 enzyme and its mammalian homolog display N-glycanase activity towards intact glycoproteins., [RefSeq, PubMed]; Loss of peptide:N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase., [RefSeq, PubMed]; Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K113;Q9CTK3", "ec_number_list": [ { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.52", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" } ], "go_molecular_function": "GO:0000224 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031012 extracellular matrix", "go_biological_process": "GO:0030513 positive regulation of BMP signaling pathway;GO:0006516 glycoprotein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9JI78-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100100000000.010.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62392-1", "uniprot_id": [ { "id": "PHLA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62392", "type": "external" } ], "mass": 45583.0, "length": 405, "protein_name": "Pleckstrin homology-like domain family A member 1", "gene_name": "Phlda1", "organism": "Mouse", "refseq_name": "pleckstrin homology-like domain family A member 1", "refseq_ac": [ { "id": "NP_033370", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033370", "type": "external" } ], "gene_names_uniprotkb": "Phlda1; Tdag51", "gene_names_refseq": "DT1P1B11; Phlda1; TDAG51; Tdag", "protein_names_uniprotkb": "Pleckstrin homology-like domain family A member 1; PQ-rich protein; PQR protein; Proline- and glutamine-rich protein; T-cell death-associated gene 51 protein", "protein_names_refseq": "PQ-rich protein; PQR protein; T-cell death associated; T-cell death-associated gene 51 protein; pleckstrin homology-like domain family A member 1; proline- and glutamine-rich protein", "tax_id": 10090, "disease": "retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:21664); (R-MMU-8854521)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10428057;10594239;12738777;15037619;31219806;34428180;37695229;37828378;38237682;38652514;8673705", "class_list": "", "function": "Egr1 promotes Nlrc4-dependent neuronal pyroptosis through phlda1 in an in-vitro model of intracerebral hemorrhage., [RefSeq, PubMed]; Knockdown of PHLDA1 alleviates sepsis-induced acute lung injury by downregulating NLRP3 inflammasome activation. Publication Status: Online-Only, [RefSeq, PubMed]; Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice., [RefSeq, PubMed]; Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. Required for TCR-induced apoptosis and expression of TNFRSF6/FAS in a T-cell hybridoma cell line. May be involved in translational regulation., [UniProtKB, PubMed, PubMed]; TDAG51 is induced by homocysteine, promotes detachment-mediated PCD, and contributes to the development of atherosclerosis observed in hyperhomocysteinemia, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TY48;Q3UG87", "ec_number_list": [], "go_molecular_function": "GO:1901981 phosphatidylinositol phosphate binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q62392-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97313-1", "uniprot_id": [ { "id": "PRKDC_MOUSE", "url": "https://www.uniprot.org/uniprot/P97313", "type": "external" } ], "mass": 471471.0, "length": 4128, "protein_name": "DNA-dependent protein kinase catalytic subunit", "gene_name": "Prkdc", "organism": "Mouse", "refseq_name": "DNA-dependent protein kinase catalytic subunit", "refseq_ac": [ { "id": "NP_035289", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035289", "type": "external" } ], "gene_names_uniprotkb": "Prkdc; Xrcc7", "gene_names_refseq": "DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH; HYRC1; Prkdc; XRCC7; dxnph; p460; scid; slip", "protein_names_uniprotkb": "DNA-dependent protein kinase catalytic subunit; 2.7.11.1; DNA-PK catalytic subunit; DNA-PKcs; p460", "protein_names_refseq": "DNA-PK catalytic subunit; DNA-dependent protein kinase catalytic subunit; doxorubicin nephropathy; severe combined immunodeficiency", "tax_id": 10090, "disease": "severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive (Disease Ontology:DOID:0090013); immunodeficiency 26 (Disease Ontology:DOID:0111961); severe combined immunodeficiency (Disease Ontology:DOID:627)", "pathway": " (mmu:19090); (R-MMU-5693571); (R-MMU-8866654)", "pathway_count": 3, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;12426399;16404475;20173027;20972425;21482716;22768239;24158435;25428506;25605945;30084848;31219806;31599954;32103174;32950644;34203471;34428180;36210013;8816463;8816792;8881030;9109492;9122213;9339376;9582343;9716665", "class_list": "", "function": "Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (By similarity). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (By similarity). Must be bound to DNA to express its catalytic properties (By similarity). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (By similarity). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (By similarity). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (By similarity). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (By similarity). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (PubMed:12426399). Also involved in modulation of transcription (By similarity). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (By similarity). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (By similarity). Recognizes the substrate consensus sequence [ST]-Q (By similarity). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (By similarity). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (By similarity). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (By similarity). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (By similarity). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (By similarity). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (PubMed:24158435). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (By similarity). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (By similarity). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QN15;O88187;P97928;Q307W9;Q3V2W8;Q8C2A7;Q9Z341", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0070419 nonhomologous end joining complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0002328 pro-B cell differentiation;GO:0050678 regulation of epithelial cell proliferation;GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0002360 T cell lineage commitment;GO:2001229 negative regulation of response to gamma radiation", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P97313-1", "record_type": "protein", "filter_code": "0000000.1100111.001000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60972-1", "uniprot_id": [ { "id": "RBBP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60972", "type": "external" } ], "mass": 47656.0, "length": 425, "protein_name": "Histone-binding protein RBBP4", "gene_name": "Rbbp4", "organism": "Mouse", "refseq_name": "histone-binding protein RBBP4", "refseq_ac": [ { "id": "NP_033056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033056", "type": "external" } ], "gene_names_uniprotkb": "Rbbp4; Rbap48", "gene_names_refseq": "RBAP48; Rbbp4; mRbAp48", "protein_names_uniprotkb": "Histone-binding protein RBBP4; CAF-1 subunit C; CAF-I 48 kDa subunit; CAF-I p48; Chromatin assembly factor 1 subunit C; Chromatin assembly factor I p48 subunit; Nucleosome-remodeling factor subunit RBAP48; RBBP-4; Retinoblastoma-binding protein 4; Retinoblastoma-binding protein p48", "protein_names_refseq": "CAF-1 p48 subunit; CAF-1 subunit C; CAF-I 48 kDa subunit; CAF-I p48; RBBP-4; chromatin assembly factor 1 subunit C; chromatin assembly factor I p48 subunit; histone-binding protein RBBP4; nucleosome-remodeling factor subunit RBAP48; retinoblastoma-binding protein 4; retinoblastoma-binding protein p48", "tax_id": 10090, "disease": "azoospermia (Disease Ontology:DOID:14227)", "pathway": " (mmu:19646); (R-MMU-1538133); (R-MMU-212300); (R-MMU-2559580); (R-MMU-3214815); (R-MMU-3214841); (R-MMU-606279); (R-MMU-6804758); (R-MMU-73762); (R-MMU-8943724); (R-MMU-8953750); (R-MMU-9764725); (R-MMU-9909649); (R-MMU-9937850); (R-MMU-9940951)", "pathway_count": 15, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;10866654;10984530;11788710;16452087;19026780;21750661;22645316;23806337;25428506;28554894;34180153;34428180;35416979;37021556;7503932;9702189", "class_list": "", "function": "Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Component of the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair (By similarity). Component of the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression (By similarity). Component of the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (By similarity). Component of the PRC2 complex, which promotes repression of homeotic genes during development (By similarity). Component of the NURF (nucleosome remodeling factor) complex (By similarity)., [UniProtKB, UniProtKB]; RBBP4 dysfunction reshapes the genomic landscape of H3K27 methylation and acetylation and disrupts gene expression., [RefSeq, PubMed]; RBBP4 is an epigenetic barrier for the induced transition of pluripotent stem cells into totipotent 2C-like cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A875", "ec_number_list": [], "go_molecular_function": "GO:0042826 histone deacetylase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0042393 histone binding;GO:0008094 ATP-dependent activity, acting on DNA", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin;GO:0035098 ESC/E(Z) complex", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q60972-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60870-1", "uniprot_id": [ { "id": "REEP5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60870", "type": "external" } ], "mass": 21051.0, "length": 185, "protein_name": "Receptor expression-enhancing protein 5", "gene_name": "Reep5", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Reep5; Dp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Receptor expression-enhancing protein 5; GP106; Polyposis locus protein 1 homolog; Protein TB2 homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "hereditary spastic paraplegia 31 (Disease Ontology:DOID:0110782)", "pathway": " (mmu:13476)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "19665976;21750661;24668814;25428506;25605945;26740625;28528544;30084848;30779550;32075961;34428180;36288343;37507081;39927985;8647449", "class_list": "", "function": "Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0014701 junctional sarcoplasmic reticulum membrane;GO:0033017 sarcoplasmic reticulum membrane;GO:0071782 endoplasmic reticulum tubular network", "go_biological_process": "GO:0090158 endoplasmic reticulum membrane organization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q60870-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68040-1", "uniprot_id": [ { "id": "RACK1_MOUSE", "url": "https://www.uniprot.org/uniprot/P68040", "type": "external" } ], "mass": 35077.0, "length": 317, "protein_name": "Small ribosomal subunit protein RACK1", "gene_name": "Rack1", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein RACK1", "refseq_ac": [ { "id": "NP_032169", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032169", "type": "external" } ], "gene_names_uniprotkb": "Rack1; Gnb2-rs1; Gnb2l1", "gene_names_refseq": "GB-like; Gnb2-rs1; Gnb2l1; Rack1; p205", "protein_names_uniprotkb": "Small ribosomal subunit protein RACK1; 12-3; Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed; Guanine nucleotide-binding protein subunit beta-2-like 1; Receptor for activated C kinase; Receptor of activated protein C kinase 1, N-terminally processed; Receptor of activated protein C kinase 1; Receptor of activated protein kinase C 1; p205", "protein_names_refseq": "12-3; activated protein kinase C receptor; guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 sequence 1; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; guanine nucleotide binding protein related; guanine nucleotide binding protein, beta 2, related sequence 1; guanine nucleotide-binding protein subunit beta-2-like 1; receptor of activated protein C kinase 1; receptor of activated protein kinase C 1; small ribosomal subunit protein RACK1", "tax_id": 10090, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (mmu:14694); (R-MMU-5357905); (R-MMU-5357956); (R-MMU-5626978); (R-MMU-9766229)", "pathway_count": 5, "publication_count": 29, "publication_id_list": "16414032;18258429;20093473;21183079;21262816;22645316;23806337;25428506;25605945;29187734;29454068;30084848;31113450;33300544;33505023;33725478;34428180;35820727;36210013;36517592;37453647;37507081;37578594;37684678;37828378;39024388;39627609;40068238;7968370", "class_list": "glycogene", "function": "Loss of RACK1 promotes glutamine addiction via activating AKT/mTOR/ASCT2 axis to facilitate tumor growth in gastric cancer., [RefSeq, PubMed]; RACK1 enhances STAT3 stability and promotes T follicular helper cell development and function during blood-stage Plasmodium infection in mice. Publication Status: Online-Only, [RefSeq, PubMed]; RACK1 mediates NLRP3 inflammasome activation during Pasteurella multocida infection. Publication Status: Online-Only, [RefSeq, PubMed]; Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules (PubMed:18258429, PubMed:20093473, PubMed:21262816, PubMed:33505023, PubMed:36517592, PubMed:7968370). Interacts with a wide variety of proteins and plays a role in many cellular processes (PubMed:18258429, PubMed:20093473, PubMed:21262816, PubMed:36517592, PubMed:7968370). Component of the 40S ribosomal subunit involved in translational repression (PubMed:36517592). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (By similarity). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation (By similarity). May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6 (By similarity). Inhibits the activity of SRC kinases including SRC, LCK and YES1 (By similarity). Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle (By similarity). Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer (PubMed:20093473). Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC (By similarity). Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix (By similarity). Involved in PKC-dependent translocation of ADAM12 to the cell membrane (By similarity). Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A (By similarity). Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation (PubMed:21262816). Required for PTK2/FAK1 phosphorylation and dephosphorylation (By similarity). Regulates internalization of the muscarinic receptor CHRM2 (By similarity). Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L (By similarity). Inhibits TRPM6 channel activity (PubMed:18258429). Regulates cell surface expression of some GPCRs such as TBXA2R (By similarity). Plays a role in regulation of FLT1-mediated cell migration (By similarity). Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (By similarity). Acts as an adapter for the dephosphorylation and inactivation of AKT1 by promoting recruitment of PP2A phosphatase to AKT1 (PubMed:33505023)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 12, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P25388;P99049;Q3THP0;Q3THY7;Q3TKQ0;Q3TW88;Q5NCC5;Q5NCC6;Q9CSQ0;Q9ERM6", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:1990630 IRE1-RACK1-PP2A complex;GO:0001891 phagocytic cup;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide;GO:0001934 positive regulation of protein phosphorylation;GO:0010629 negative regulation of gene expression;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P68040-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHD0-1", "uniprot_id": [ { "id": "RB39A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHD0", "type": "external" } ], "mass": 24978.0, "length": 217, "protein_name": "Ras-related protein Rab-39A", "gene_name": "Rab39a", "organism": "Mouse", "refseq_name": "ras-related protein Rab-39A", "refseq_ac": [ { "id": "NP_780771", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780771", "type": "external" } ], "gene_names_uniprotkb": "Rab39a; Rab39", "gene_names_refseq": "C230094F14Rik; Rab39a; Rab39", "protein_names_uniprotkb": "Ras-related protein Rab-39A; 3.6.5.2; Rab-39", "protein_names_refseq": "rab-39; ras-related protein Rab-39A", "tax_id": 10090, "disease": "", "pathway": " (mmu:270160); (R-MMU-6811438); (R-MMU-8873719); (R-MMU-8876198)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "23294242;23624502;24349490;31821587;33300544", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB39A regulates autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex onto lysosomes; this process involves lysosomal RAB39A and autophagosomal RAB2A recruitment of HOPS subcomplexes VPS41-VPS16-VPS18-VPS33A and VPS39-VPS11, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion (By similarity). Also negatively regulates lipopolysaccharide (LPS)-induced autophagosome formation in macrophages, possibly by implicating PI3K (By similarity). Promotes the delivery of MHC-I molecules from the ER to phagosomes and the generation of peptide-loaded MHC-I complexes in phagosomes, thus enhancing antigen cross-presentation by dendritic cells (PubMed:31821587). Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes (By similarity). May be involved in multiple neurite formation (PubMed:23624502)., [UniProtKB, PubMed, UniProtKB, PubMed]; These results suggest that Rab39a negatively regulates the LPS-induced autophagy in macrophages Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0030670 phagocytic vesicle membrane;GO:0045335 phagocytic vesicle", "go_biological_process": "GO:0090383 phagosome acidification;GO:0015031 protein transport;GO:0016192 vesicle-mediated transport;GO:0032482 Rab protein signal transduction;GO:0090385 phagosome-lysosome fusion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BHD0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYS9-1", "uniprot_id": [ { "id": "QKI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYS9", "type": "external" } ], "mass": 37671.0, "length": 341, "protein_name": "KH domain-containing RNA-binding protein QKI", "gene_name": "Qki", "organism": "Mouse", "refseq_name": "KH domain-containing RNA-binding protein QKI isoform 2", "refseq_ac": [ { "id": "NP_001152988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152988", "type": "external" } ], "gene_names_uniprotkb": "Qki; Qk1; Qk", "gene_names_refseq": "1110003F05Rik; 1500005P18; Qki; Qk; l(17)-1Wis; l17Wis1", "protein_names_uniprotkb": "KH domain-containing RNA-binding protein QKI; MqkI; Protein quaking", "protein_names_refseq": "KH domain-containing RNA-binding protein QKI isoform 2; KH domain-containing RNA-binding protein QKI; QKI-5 protein; QKI-6 protein; QKI-7 protein; QKI-7b protein; lethal, Chr 17, U Wisconsin 1; protein quaking", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:19317)", "pathway_count": 1, "publication_count": 53, "publication_id_list": "10.1101/2023.09.13.557529;10328999;10384037;10506177;10535969;10864952;11297509;11892011;11917126;12467586;12529443;12682013;12888522;14706070;15014970;15528192;15568022;16041388;16198329;16470614;20956316;21253564;21750661;22982292;24129315;28188285;29021242;29237092;31868295;32732889;32782141;32848054;33045062;33378678;33397958;33750804;33942715;34021134;36088389;36288343;36627242;36852467;37272356;37460362;39226364;40021952;40885482;40997131;8589716;8987822;9315629;9671495;9778149", "class_list": "", "function": "Cytosolic isoform that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) (By similarity). Interaction with G3BP1 promotes localization of m7G-containing mRNAs into stress granules in response to stress, thereby suppressing their translation (By similarity). Acts as a negative regulator of angiogenesis by binding to mRNAs encoding CDH5, NLGN1 and TNFAIP6, promoting their degradation (PubMed:32732889). Can also induce apoptosis in the cytoplasm (PubMed:11297509). Heterodimerization with other isoforms results in nuclear translocation of isoform QKI7 and suppression of apoptosis (PubMed:11297509). Also binds some microRNAs: promotes stabilitation of miR-122 by mediating recruitment of poly(A) RNA polymerase TENT2, leading to 3' adenylation and stabilization of miR-122 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Nuclear isoform that acts as an indirect regulator of mRNA splicing (PubMed:11917126, PubMed:29021242). Regulates mRNA splicing of MAG pre-mRNA by inhibiting translation of HNRNPA1 mRNA, thereby preventing MAG exon 12 alternative splicing (PubMed:11917126, PubMed:21253564). Involved in oligodendrocyte differentiation by promoting stabilization of SIRT2 mRNA (PubMed:28188285). Acts as a negative regulator of the interferon response by binding to MAVS mRNA, downregulating its expression (By similarity). Also inhibits the interferon response by binding to fibrinectin FN1 pre-mRNA, repressing EDA exon inclusion in FN1 (By similarity). Delays macrophage differentiation by binding to CSF1R mRNA, promoting its degradation (By similarity). In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2, promoting SREBF2/SREBP2-dependent cholesterol biosynthesis (PubMed:33942715, PubMed:34021134). SREBF2/SREBP2-dependent cholesterol biosynthesis participates to myelinization and is required for eye lens transparency (PubMed:33942715, PubMed:34021134)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Qki5 safeguards spinal motor neuron function by defining the motor neuron-specific transcriptome via pre-mRNA processing., [RefSeq, PubMed]; RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation (PubMed:10535969, PubMed:11297509, PubMed:11917126, PubMed:12467586, PubMed:15568022, PubMed:31868295, PubMed:36088389). Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development (PubMed:10535969, PubMed:11297509, PubMed:11917126, PubMed:12467586, PubMed:15568022, PubMed:31868295). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence (PubMed:16041388). Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) (By similarity). Promotes the formation of circular RNAs (circRNAs) during the epithelial to mesenchymal transition and in cardiomyocytes: acts by binding to sites flanking circRNA-forming exons (PubMed:37272356). CircRNAs are produced by back-splicing circularization of pre-mRNAs (PubMed:37272356). Plays a central role in myelinization via 3 distinct mechanisms (PubMed:10864952, PubMed:11917126, PubMed:12467586, PubMed:15568022, PubMed:20956316, PubMed:21253564). First, acts by protecting and promoting stability of target mRNAs such as MBP, SIRT2 and CDKN1B, which promotes oligodendrocyte differentiation (PubMed:10864952, PubMed:15568022, PubMed:28188285). Second, participates in mRNA transport by regulating the nuclear export of MBP mRNA (PubMed:12467586). Finally, indirectly regulates mRNA splicing of MAG pre-mRNA during oligodendrocyte differentiation by acting as a negative regulator of MAG exon 12 alternative splicing: acts by binding to HNRNPA1 mRNA splicing factor, preventing its translation (PubMed:11917126, PubMed:20956316, PubMed:21253564). Involved in microglia differentiation and remyelination by regulating microexon alternative splicing of the Rho GTPase pathway (PubMed:33045062, PubMed:33378678). Involved in macrophage differentiation: promotes monocyte differentiation by regulating pre-mRNA splicing in naive peripheral blood monocytes (PubMed:36088389). Acts as an important regulator of muscle development: required for the contractile function of cardiomyocytes by regulating alternative splicing of cardiomyocyte transcripts (PubMed:33397958, PubMed:36627242). Acts as a negative regulator of thermogenesis by decreasing stability, nuclear export and translation of mRNAs encoding PPARGC1A and UCP1 (PubMed:31868295). Also required for visceral endoderm function and blood vessel development (PubMed:11892011, PubMed:16470614). May also play a role in smooth muscle development (PubMed:14706070). In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2 (PubMed:33942715, PubMed:34021134)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; RNA-binding Protein QKI Inhibits Osteogenic Differentiation Via Suppressing Wnt Pathway., [RefSeq, PubMed]; The RNA-binding protein QKI governs a muscle-specific alternative splicing program that shapes the contractile function of cardiomyocytes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "O88972;Q61110;Q78ZE4;Q78ZE5;Q8K4X9;Q8K4Y0;Q9CW34;Q9QUH4;Q9R2A8;Q9Z246", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0035886 vascular associated smooth muscle cell differentiation;GO:0001570 vasculogenesis;GO:0006397 mRNA processing;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 6.2, "record_id": "Q9QYS9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHX7-1", "uniprot_id": [ { "id": "RFTN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHX7", "type": "external" } ], "mass": 54972.0, "length": 500, "protein_name": "Raftlin-2", "gene_name": "Rftn2", "organism": "Mouse", "refseq_name": "raftlin-2 isoform 1", "refseq_ac": [ { "id": "NP_082989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082989", "type": "external" } ], "gene_names_uniprotkb": "Rftn2", "gene_names_refseq": "2700010E02Rik; 3222401M22Rik; Rftn2", "protein_names_uniprotkb": "Raftlin-2; Raft-linking protein 2", "protein_names_refseq": "raft-linking protein 2; raftlin-2 isoform 1; raftlin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74013)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;19414744;21183079;21750661;27022195;34428180", "class_list": "", "function": "Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195). May regulate B-cell antigen receptor-mediated signaling., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R306;Q9CXJ5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0043330 response to exogenous dsRNA;GO:0033227 dsRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8CHX7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1J5-1", "uniprot_id": [ { "id": "SDE2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1J5", "type": "external" } ], "mass": 48580.0, "length": 448, "protein_name": "Splicing regulator SDE2", "gene_name": "Sde2", "organism": "Mouse", "refseq_name": "splicing regulator SDE2", "refseq_ac": [ { "id": "NP_666055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666055", "type": "external" } ], "gene_names_uniprotkb": "Sde2", "gene_names_refseq": "Sde2", "protein_names_uniprotkb": "Splicing regulator SDE2; Replication stress response regulator SDE2", "protein_names_refseq": "UPF0667 protein C1orf55 homolog; protein SDE2 homolog; replication stress response regulator SDE2; splicing regulator SDE2", "tax_id": 10090, "disease": "", "pathway": " (mmu:208768); (R-MMU-72163)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17242355;19144319;21183079;28135057", "class_list": "", "function": "Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress (By similarity). SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage (By similarity)., [UniProtKB, UniProtKB]; Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content (By similarity). May recruit CACTIN to the spliceosome (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor (By similarity). Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJX1", "ec_number_list": [], "go_molecular_function": "GO:0003684 damaged DNA binding;GO:0030515 snoRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0016485 protein processing;GO:0051301 cell division;GO:0006260 DNA replication;GO:0016567 protein ubiquitination;GO:0034644 cellular response to UV", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K1J5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z315-1", "uniprot_id": [ { "id": "SNUT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z315", "type": "external" } ], "mass": 90885.0, "length": 806, "protein_name": "U4/U6.U5 tri-snRNP-associated protein 1", "gene_name": "Sart1", "organism": "Mouse", "refseq_name": "U4/U6.U5 tri-snRNP-associated protein 1", "refseq_ac": [ { "id": "NP_058578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058578", "type": "external" } ], "gene_names_uniprotkb": "Sart1; Haf", "gene_names_refseq": "Sart1; U5-110K", "protein_names_uniprotkb": "U4/U6.U5 tri-snRNP-associated protein 1; Hypoxia-associated factor; SART-1; Squamous cell carcinoma antigen recognized by T-cells 1; mSART-1", "protein_names_refseq": "SART-1; U4/U6.U5 tri-snRNP-associated protein 1; hypoxia-associated factor; mSART-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:20227); (R-MMU-72163)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10887110;11410364;21183079;21750661;25428506;26799785;31219806;31599954;34887587;39627609;9765622", "class_list": "", "function": "Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA., [UniProtKB, UniProtKB, PubMed]; SART1(+/-) mice showed significant up-regulation of HIF-1alpha in circulating and liver-infiltrating immune cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K155;Q9R1I9;Q9R270", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000481 maturation of 5S rRNA;GO:0045585 positive regulation of cytotoxic T cell differentiation;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9Z315-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35324-1", "uniprot_id": [ { "id": "SH21B_MOUSE", "url": "https://www.uniprot.org/uniprot/O35324", "type": "external" } ], "mass": 15259.0, "length": 132, "protein_name": "SH2 domain-containing protein 1B", "gene_name": "Sh2d1b", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sh2d1b; Eat2a; Eat2; Sh2d1b1", "gene_names_refseq": "", "protein_names_uniprotkb": "SH2 domain-containing protein 1B; EAT-2; EWS/FLI1-activated transcript 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 9, "publication_id_list": "11689425;16127454;16425036;19151721;20962259;21219180;24687958;26432891;9000139", "class_list": "", "function": "Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244. In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4. However, conflicting results are reported which may reflect the use of different strain backgrounds. Proposed to act as an inhibitor of CD244-mediated NK cell function including cytotoxicity and IFN-gamma production, the latter found also by triggering KLRA4 and KLRK1 next to CD244 (PubMed:16127454). Seems to positively regulate CD244- and CD84-dependent NK cell functions implicating CD244-mediated phosphorylation of VAV1. Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (PubMed:19151721, PubMed:20962259, PubMed:24687958). In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse (PubMed:24687958). Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation (PubMed:26432891)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C268", "ec_number_list": [], "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "", "go_biological_process": "GO:0002717 positive regulation of natural killer cell mediated immunity;GO:0002366 leukocyte activation involved in immune response;GO:0002250 adaptive immune response;GO:0009967 positive regulation of signal transduction;GO:0045953 negative regulation of natural killer cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35324-1", "record_type": "protein", "filter_code": "0000000.0100100.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35242-1", "uniprot_id": [ { "id": "SFTPA_MOUSE", "url": "https://www.uniprot.org/uniprot/P35242", "type": "external" } ], "mass": 26157.0, "length": 248, "protein_name": "Pulmonary surfactant-associated protein A", "gene_name": "Sftpa1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sftpa1; Sftp-1; Sftp1; Sftpa", "gene_names_refseq": "", "protein_names_uniprotkb": "Pulmonary surfactant-associated protein A; PSAP; PSP-A; SP-A", "protein_names_refseq": "", "tax_id": 10090, "disease": "sinusitis (Disease Ontology:DOID:0050127); interstitial lung disease 1 (Disease Ontology:DOID:0060941); interstitial lung disease 2 (Disease Ontology:DOID:0060971); adult respiratory distress syndrome (Disease Ontology:DOID:11394); pulmonary edema (Disease Ontology:DOID:11396); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); pulmonary sarcoidosis (Disease Ontology:DOID:13406); cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary fibrosis (Disease Ontology:DOID:3770); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); pneumonia (Disease Ontology:DOID:552); extrinsic allergic alveolitis (Disease Ontology:DOID:841); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-MMU-166016); (R-MMU-391160); (R-MMU-5683826); (R-MMU-5686938)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "1443158;25965346;30084848;31601679", "class_list": "glycogene", "function": "In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages (PubMed:25965346)., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005771 multivesicular body", "go_biological_process": "GO:0007585 respiratory gaseous exchange by respiratory system;GO:0050766 positive regulation of phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P35242-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000011000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CI12-1", "uniprot_id": [ { "id": "SMTL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CI12", "type": "external" } ], "mass": 49523.0, "length": 456, "protein_name": "Smoothelin-like protein 2", "gene_name": "Smtnl2", "organism": "Mouse", "refseq_name": "smoothelin-like protein 2", "refseq_ac": [ { "id": "NP_808444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808444", "type": "external" } ], "gene_names_uniprotkb": "Smtnl2", "gene_names_refseq": "D130058I21Rik; Smtnl2", "protein_names_uniprotkb": "Smoothelin-like protein 2", "protein_names_refseq": "smoothelin-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:276829)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17242355;21183079;21750661;34428180;35551947;39927985", "class_list": "", "function": "Smtnl2 regulates apoptotic germ cell clearance and lactate metabolism in mouse Sertoli cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8CI12-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61466-1", "uniprot_id": [ { "id": "SMRD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61466", "type": "external" } ], "mass": 58245.0, "length": 515, "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1", "gene_name": "Smarcd1", "organism": "Mouse", "refseq_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 isoform 1", "refseq_ac": [ { "id": "NP_114030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114030", "type": "external" } ], "gene_names_uniprotkb": "Smarcd1; Baf60a; D15Kz1", "gene_names_refseq": "Baf60a; D15Kz1; Smarcd1", "protein_names_uniprotkb": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1; 60 kDa BRG-1/Brm-associated factor subunit A; BAF60A; BRG1-associated factor 60A; Protein D15KZ1; SWI/SNF complex 60 kDa subunit", "protein_names_refseq": "60 kDa BRG-1/Brm-associated factor subunit A; BRG1-associated factor 60A; SWI/SNF complex 60 kDa subunit; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 isoform 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1", "tax_id": 10090, "disease": "Coffin-Siris syndrome 11 (Disease Ontology:DOID:0112372); familial hyperlipidemia (Disease Ontology:DOID:1168); alcohol use disorder (Disease Ontology:DOID:1574); Coffin-Siris syndrome (Disease Ontology:DOID:1925)", "pathway": " (mmu:83797); (R-MMU-3214858); (R-MMU-8939243); (R-MMU-9933937); (R-MMU-9933939); (R-MMU-9933946); (R-MMU-9933947); (R-MMU-9934037)", "pathway_count": 8, "publication_count": 12, "publication_id_list": "17640523;21750661;23806337;24129315;25107474;2725507;29272704;29374058;34887587;35822944;8804307;8895581", "class_list": "", "function": "BAF60a Deficiency in Macrophage Promotes Diet-Induced Obesity and Metabolic Inflammation., [RefSeq, PubMed]; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P70384;Q8R0I7", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003682 chromatin binding;GO:0005102 signaling receptor binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0071564 npBAF complex;GO:0016363 nuclear matrix", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:2000819 regulation of nucleotide-excision repair;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q61466-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62233-1", "uniprot_id": [ { "id": "SIX3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62233", "type": "external" } ], "mass": 35593.0, "length": 333, "protein_name": "Homeobox protein SIX3", "gene_name": "Six3", "organism": "Mouse", "refseq_name": "homeobox protein SIX3", "refseq_ac": [ { "id": "NP_035511", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035511", "type": "external" } ], "gene_names_uniprotkb": "Six3", "gene_names_refseq": "E130112M24Rik; Six3alpha; Six3a; Six3beta; Six3b; Six3", "protein_names_uniprotkb": "Homeobox protein SIX3; Sine oculis homeobox homolog 3", "protein_names_refseq": "homeobox protein SIX3; sine oculis homeobox homolog 3; sine oculis-related homeobox 3 homolog", "tax_id": 10090, "disease": "holoprosencephaly 2 (Disease Ontology:DOID:0110872); holoprosencephaly (Disease Ontology:DOID:4621)", "pathway": " (mmu:20473)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "11139622;11458394;12050133;12072567;12163408;12569128;16024294;17066077;17576749;17666527;18094027;18694563;18775421;19606496;20682799;20890044;22071110;23792023;39025297;8575305;8814301", "class_list": "", "function": "The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice., [RefSeq, PubMed]; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon (PubMed:18094027). Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression (PubMed:18775421). In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration (PubMed:22071110). Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 AND CCND2 (PubMed:17576749). During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm (PubMed:17066077). In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation (PubMed:12072567). Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory (PubMed:20890044). Its action during retina development and lens morphogenesis is TLE5 and TLE4-dependent manner. Furthermore, during eye development regulates several genes expression. Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element (PubMed:11139622). Directly activates RHO transcription, or cooperates with CRX or NRL (PubMed:17666527). Six3 also functions in the formation of the proximodistal axis of the optic cup (PubMed:12163408), and promotes the formation of optic vesicles-like structures (PubMed:11458394). During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway (PubMed:18694563). Plays a role in eye development by suppressing WNT1 expression and in dorsal-ventral patterning by repressing BMP signaling pathway (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70176;P70177;Q4QQQ3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005102 signaling receptor binding;GO:0042826 histone deacetylase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0014016 neuroblast differentiation;GO:0030878 thyroid gland development;GO:1990086 lens fiber cell apoptotic process;GO:0061074 regulation of neural retina development;GO:0021536 diencephalon development", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q62233-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TE4-1", "uniprot_id": [ { "id": "SI1L2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TE4", "type": "external" } ], "mass": 189413.0, "length": 1722, "protein_name": "Signal-induced proliferation-associated 1-like protein 2", "gene_name": "Sipa1l2", "organism": "Mouse", "refseq_name": "signal-induced proliferation-associated 1-like protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001074806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074806", "type": "external" } ], "gene_names_uniprotkb": "Sipa1l2; Kiaa0545", "gene_names_refseq": "Sipa1l2; mKIAA1389", "protein_names_uniprotkb": "Signal-induced proliferation-associated 1-like protein 2; SIPA1-like protein 2", "protein_names_refseq": "SIPA1-like protein 2; signal-induced proliferation-associated 1-like protein 2 isoform 1; signal-induced proliferation-associated 1-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:244668)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;16452087;21183079;21750661;22645316;30016717;31784514;34428180;36210013;36852467;38472136;40021952;40885482", "class_list": "", "function": "SIPA1L2, which connects TrkB amphisomes to a dynein motor, orchestrates neuronal amphisomal trafficking of BDNF/TrkB at presynaptic boutons during retrograde transport to the soma. Publication Status: Online-Only, [RefSeq, PubMed]; Testing SIPA1L2 as a modifier of CMT1A using mouse models., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "E9QPK7;Q6PDY1", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098793 presynapse;GO:0099092 postsynaptic density, intracellular component", "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:0098928 presynaptic signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q80TE4-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42227-1", "uniprot_id": [ { "id": "STAT3_MOUSE", "url": "https://www.uniprot.org/uniprot/P42227", "type": "external" } ], "mass": 88054.0, "length": 770, "protein_name": "Signal transducer and activator of transcription 3", "gene_name": "Stat3", "organism": "Mouse", "refseq_name": "signal transducer and activator of transcription 3 isoform 1", "refseq_ac": [ { "id": "NP_998824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998824", "type": "external" } ], "gene_names_uniprotkb": "Stat3; Aprf", "gene_names_refseq": "1110034C02Rik; Aprf; Stat3", "protein_names_uniprotkb": "Signal transducer and activator of transcription 3; Acute-phase response factor", "protein_names_refseq": "acute phase response factor; signal transducer and activator of transcription 3 isoform 1", "tax_id": 10090, "disease": "angiosarcoma (Disease Ontology:DOID:0001816); idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); inflammatory bowel disease (Disease Ontology:DOID:0050589); pre-malignant neoplasm (Disease Ontology:DOID:0060071); lymphoproliferative syndrome (Disease Ontology:DOID:0060704); infantile onset multisystem autoimmune disease 1 (Disease Ontology:DOID:0061160); colorectal carcinoma (Disease Ontology:DOID:0080199); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); nasal type extranodal NK/T-cell lymphoma (Disease Ontology:DOID:0080797); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); chronic lymphocytic leukemia (Disease Ontology:DOID:1040); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); esophageal carcinoma (Disease Ontology:DOID:1107); heart disease (Disease Ontology:DOID:114); neutropenia (Disease Ontology:DOID:1227); Behcet's disease (Disease Ontology:DOID:13241); breast cancer (Disease Ontology:DOID:1612); duodenal ulcer (Disease Ontology:DOID:1724); squamous cell carcinoma (Disease Ontology:DOID:1749); hyperuricemia (Disease Ontology:DOID:1920); atherosclerosis (Disease Ontology:DOID:1936); rectum adenocarcinoma (Disease Ontology:DOID:1996); nephroblastoma (Disease Ontology:DOID:2154); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); colon adenocarcinoma (Disease Ontology:DOID:234); ovarian cancer (Disease Ontology:DOID:2394); Churg-Strauss syndrome (Disease Ontology:DOID:3049); glioblastoma (Disease Ontology:DOID:3068); autosomal dominant hyper-IgE syndrome 1 with recurrent infections (Disease Ontology:DOID:3261); angiomyolipoma (Disease Ontology:DOID:3314); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); skin melanoma (Disease Ontology:DOID:8923); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); psoriatic arthritis (Disease Ontology:DOID:9008); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); peripartum cardiomyopathy (Disease Ontology:DOID:9997)", "pathway": " (mmu:20848); (R-MMU-1059683); (R-MMU-1266695); (R-MMU-1433557); (R-MMU-186763); (R-MMU-201556); (R-MMU-6783783); (R-MMU-6785807); (R-MMU-8849474); (R-MMU-8854691); (R-MMU-8875791); (R-MMU-8983432); (R-MMU-8984722); (R-MMU-8985947); (R-MMU-9008059); (R-MMU-9020933); (R-MMU-9020956); (R-MMU-9020958); (R-MMU-9701898); (R-MMU-9833482); (R-MMU-9958825)", "pathway_count": 21, "publication_count": 420, "publication_id_list": "10.1101/2023.09.13.557529;10878010;10896772;10954736;11161808;11294897;11553624;11591769;11830592;12049654;12594516;12637586;12684046;14617800;14673173;15004007;15007380;15096606;15328362;15705584;15781265;15919823;15936723;16172266;16377083;16401721;16417589;16825198;17064687;17283176;17401459;17583567;17606840;17683579;18025205;18034455;18158318;18234692;18299400;18356286;18403479;18489773;18500982;18519567;18723372;18794085;18795895;19071214;19224205;19284588;19299019;19380824;19538478;19696070;20107108;20151299;20173027;20215569;20300524;20484139;20484733;20595392;20871632;20959490;21056997;21135090;21183079;21223971;21291541;21354226;21480396;21486047;21518725;21617181;21750661;21809363;21810913;21952136;21997191;22074622;22110749;22206672;22268811;22348200;22454509;22511936;22517741;22614008;22645316;22824293;22844518;22872234;22875246;22907754;22911886;22992748;23084476;23109669;23114963;23118721;23166634;23216800;23329648;23364341;23374901;23401489;23416975;23434585;23530005;23531921;23533666;23589566;23593315;23665018;23693126;23750710;23807298;23811270;23842188;23917203;23972987;23979021;24019511;24093616;24130924;24132923;24152426;24223854;24260381;24286865;24302476;24323291;24376586;24410832;24416452;24449804;24508558;24606867;24619572;24655440;24681959;24682898;24744866;24788674;24789104;24806510;24819473;24850910;24887420;24975845;25025494;25147435;25150294;25153642;25200186;25216522;25275304;25331984;25337545;25412315;25428506;25428507;25432886;25460165;25512545;25568075;25581158;25605945;25611086;25741592;25788267;25868979;25880134;26026268;26034351;26061710;26075036;26198700;26241748;26247733;26255791;26260587;26317647;26378915;26380299;26398946;26413468;26444028;26491103;26512963;26556875;26573296;26575024;26612419;26633714;26764350;26775702;26789017;26823495;26826115;26830149;26848037;26866564;26892021;26910359;26911838;26919063;26923837;26980746;27021905;27050378;27050391;27080032;27102301;27215660;27217982;27306323;27384491;27430527;27449092;27524110;27537526;27579617;27582544;27589562;27641629;27706259;27724964;27779705;27795451;27829437;27835873;27840174;27886188;28011936;28066259;28082079;28101184;28106119;28135057;28162277;28178326;28273928;28280036;28320842;28338101;28383060;28383063;28386145;28400195;28415722;28445952;28453725;28508871;28528544;28542400;28554144;28591717;28596565;28625915;28642132;28642362;28669599;28706517;28750090;28848431;28849098;28870220;28903339;28938568;29016674;29047406;29074644;29079839;29202102;29238104;29254203;29262585;29263930;29284516;29304053;29340087;29382715;29458077;29507229;29683527;29729074;29743632;29797458;29867489;29924996;30070632;30084848;30107531;30108694;30143645;30206377;30224299;30266298;30333721;30353167;30364083;30528455;30542122;30559339;30606233;30648776;30741923;30779550;30791634;30818341;30870482;30899259;30918582;30924297;30953001;30988739;30993885;30996264;31049028;31066230;31072360;31073117;31115390;31161238;31176371;31217524;31219806;31292446;31315045;31474764;31474988;31506552;31552035;31581535;31601900;31616917;31683879;31699972;31770366;31780948;31803051;31819365;31862381;31885639;31924750;32025217;32041943;32064174;32183406;32210977;32286285;32308756;32312954;32467752;32483468;32527985;32627301;32694788;32732870;32782141;32797246;32820305;32848054;32871210;32943679;32999332;33040485;33082817;33287358;33294147;33298620;33332446;33361763;33413536;33428604;33491667;33500396;33539470;33595435;33672392;33758164;33803551;33824326;33828598;33859760;33985537;34203471;34428180;35312906;35411090;35452800;35585990;35732128;35806005;35820727;35822049;35917766;35983049;35984892;35995859;36010614;36030776;36210013;36852467;37058110;37828378;38191912;38437956;40021952;40885482;40997131;7512451;7523373;7543024;7568080;8140422;9108058;9388184;9671298", "class_list": "", "function": "Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:23917203, PubMed:26026268). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (By similarity). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes (By similarity). Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acetylation promotes its transcription activity and cell differentiation while deacetylation and oxidation of lysine residues by LOXL3 inhibits differentiation (By similarity). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (By similarity). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (PubMed:12594516). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:16825198). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (By similarity). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (PubMed:20215569). Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (PubMed:19538478). Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (PubMed:23401489). Involved in the oncostatin-M-mediated signaling pathway through both type I OSM receptor complex (heterodimers composed of LIFR and IL6ST) and type II OSM receptor complex (heterodimers composed of OSMR and IL6ST) (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 50, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A2A5D1;B7ZC17", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003723 RNA binding;GO:0005102 signaling receptor binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0070120 ciliary neurotrophic factor-mediated signaling pathway;GO:0038110 interleukin-2-mediated signaling pathway;GO:0048708 astrocyte differentiation;GO:2001171 positive regulation of ATP biosynthetic process;GO:1905564 positive regulation of vascular endothelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 42.9, "record_id": "P42227-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BVK9-1", "uniprot_id": [ { "id": "SP110_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BVK9", "type": "external" } ], "mass": 50140.0, "length": 445, "protein_name": "Sp110 nuclear body protein", "gene_name": "Sp110", "organism": "Mouse", "refseq_name": "sp110 nuclear body protein isoform 1", "refseq_ac": [ { "id": "NP_084470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084470", "type": "external" } ], "gene_names_uniprotkb": "Sp110; Ifi75; Ipr1", "gene_names_refseq": "5031415C07Rik; 52kDa; 5830484A20Rik; Ifi75; Ipr1; Sp110", "protein_names_uniprotkb": "Sp110 nuclear body protein; Intracellular pathogen resistance protein 1", "protein_names_refseq": "interferon-induced protein 75, 52kD; intracellular pathogen resistance 1; intracellular pathogen resistance protein 1; sp110 nuclear body protein isoform 1", "tax_id": 10090, "disease": "hepatic venoocclusive disease with immunodeficiency (Disease Ontology:DOID:0112254); tuberculosis (Disease Ontology:DOID:399)", "pathway": " (mmu:109032)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11471051;15815631;19144319;19892989;20173027;20221700;21183079;21790702;25605945;27802388;27858493;30059200;30084848;30779550;34428180", "class_list": "", "function": "Data indicate that the Ipr1 gene product might have a previously undocumented function in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death and pathogenesis, [RefSeq, PubMed]; Identification and analysis of the genes Sp100, Csprs, and Ifi75 in two members of the genus Mus, M. musculus and M. caroli, [RefSeq, PubMed]; Ipr1 might be involved in apoptosis pathway via MYBBP1A., [RefSeq, PubMed]; May act as a transcription factor. Plays a role in the innate immunity against intracellular pathogens. Required for resistance to M.tuberculosis and L.monocytogenes. Promotes apoptosis of infected cells., [UniProtKB, PubMed]; Mediates RAW 264.7 macrophage cell line resistance to Mycobacterium bovis, [RefSeq, PubMed]; Using mouse models and genetic characteristics of human patients the role of SP110b was studied to determine its role in controlling host immunity and susceptibility to TB by modulating nuclear factor-kappaB (NF-kappaB) activity resulting in down regulation of TNF-alpha production and upregulation of NF-kappaB-induced antipoptotic gene expression suppressing IFN-gamma-mediated monocyte and/or macrophage cell death., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q05D41;Q3UCV7;Q80V00", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043065 positive regulation of apoptotic process;GO:0045087 innate immune response;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8BVK9-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01279-1", "uniprot_id": [ { "id": "EGFR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q01279", "type": "external" } ], "mass": 134853.0, "length": 1210, "protein_name": "Epidermal growth factor receptor", "gene_name": "Egfr", "organism": "Mouse", "refseq_name": "epidermal growth factor receptor isoform 1 precursor", "refseq_ac": [ { "id": "NP_997538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997538", "type": "external" } ], "gene_names_uniprotkb": "Egfr", "gene_names_refseq": "9030024J15Rik; Egfr; Erbb; Errb1; Errp; Wa5; wa-2; wa2", "protein_names_uniprotkb": "Epidermal growth factor receptor; 2.7.10.1", "protein_names_refseq": "avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; epidermal growth factor receptor isoform 1 precursor; waved 2", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); nicotine dependence (Disease Ontology:DOID:0050742); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); neonatal nephrocutaneous inflammatory syndrome (Disease Ontology:DOID:0061191); Coronavirus infectious disease (Disease Ontology:DOID:0080599); Parkinsonism (Disease Ontology:DOID:0080855); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); dilated cardiomyopathy (Disease Ontology:DOID:12930); dementia (Disease Ontology:DOID:1307); lung cancer (Disease Ontology:DOID:1324); peptic esophagitis (Disease Ontology:DOID:13976); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); pulmonary tuberculosis (Disease Ontology:DOID:2957); acute kidney failure (Disease Ontology:DOID:3021); carcinoma (Disease Ontology:DOID:305); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); breast carcinoma (Disease Ontology:DOID:3459); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); median neuropathy (Disease Ontology:DOID:571); aortic valve disease (Disease Ontology:DOID:62); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); lung disease (Disease Ontology:DOID:850); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:13649); (R-MMU-1227986); (R-MMU-1236394); (R-MMU-1250196); (R-MMU-1257604); (R-MMU-177929); (R-MMU-179812); (R-MMU-180292); (R-MMU-180336); (R-MMU-182971); (R-MMU-1963642); (R-MMU-212718); (R-MMU-2179392); (R-MMU-445144); (R-MMU-5673001); (R-MMU-6785631); (R-MMU-6811558); (R-MMU-8847993); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-8857538); (R-MMU-8863795); (R-MMU-9009391); (R-MMU-9013507)", "pathway_count": 24, "publication_count": 36, "publication_id_list": "10.1101/2023.09.13.557529;10953014;1408137;16122376;16420529;16944957;17242355;17330941;17909029;17927446;18515860;1860884;2030916;20639532;21183079;21750661;22872234;23418353;25428506;25744720;27101391;30084848;30779550;30899004;31219806;31599954;32494592;34428180;35131940;37828378;7618084;7618085;7630400;7678348;8125255;8404850", "class_list": "", "function": "Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:8404850). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (By similarity). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (By similarity). Plays a role in enhancing learning and memory performance (PubMed:20639532). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (PubMed:35131940)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 30, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 46, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0004713 protein tyrosine kinase activity;GO:0004888 transmembrane signaling receptor activity;GO:0005102 signaling receptor binding;GO:0005178 integrin binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0098978 glutamatergic synapse;GO:0097708 intracellular vesicle;GO:0000139 Golgi membrane;GO:0005634 nucleus", "go_biological_process": "GO:1902966 positive regulation of protein localization to early endosome;GO:0060252 positive regulation of glial cell proliferation;GO:0001934 positive regulation of protein phosphorylation;GO:0007165 signal transduction;GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 5.1, "record_id": "Q01279-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JID9-1", "uniprot_id": [ { "id": "SH2B2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JID9", "type": "external" } ], "mass": 66557.0, "length": 621, "protein_name": "SH2B adapter protein 2", "gene_name": "Sh2b2", "organism": "Mouse", "refseq_name": "SH2B adapter protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001289867", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289867", "type": "external" } ], "gene_names_uniprotkb": "Sh2b2; Aps", "gene_names_refseq": "Aps; Sh2b2", "protein_names_uniprotkb": "SH2B adapter protein 2; Adapter protein with pleckstrin homology and Src homology 2 domains; SH2 and PH domain-containing adapter protein APS", "protein_names_refseq": "SH2 and PH domain-containing adapter protein APS; SH2B adapter protein 2 isoform 1; SH2B adapter protein 2; adapter protein with pleckstrin homology and Src homology 2 domains; adaptor protein with pleckstrin homology and src homology 2 domains; insulin receptor substrate 5", "tax_id": 10090, "disease": "chromosome 16p11.2 deletion syndrome, 220-kb (Disease Ontology:DOID:0060398)", "pathway": " (mmu:23921); (R-MMU-1433559); (R-MMU-983231)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10872802;11997497;12444928;16141217;17242355;17620296;19144319;21183079;21750661;24358267;39090233", "class_list": "", "function": "Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3 (By similarity)., [UniProtKB]; Control of germinal center B cell survival and IgE production by an adaptor molecule containing PH and SH2 domains, Aps/Sh2b2. Publication Status: Online-Only, [RefSeq, PubMed]; Deletion of liver SH2B1 in SH2B2 null mice attenuated very low-density lipoprotein (VLDL) secretion. Publication Status: Online-Only, [RefSeq, PubMed]; The association between SHIP2 and the adaptor protein Aps has an impact on biochemical properties of both partners., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88936;Q6PG00", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042169 SH2 domain binding;GO:0035591 signaling adaptor activity;GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0001725 stress fiber", "go_biological_process": "GO:0007399 nervous system development;GO:0035556 intracellular signal transduction;GO:0050873 brown fat cell differentiation;GO:0030036 actin cytoskeleton organization;GO:0050776 regulation of immune response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9JID9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZH6-1", "uniprot_id": [ { "id": "ECSIT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZH6", "type": "external" } ], "mass": 49799.0, "length": 435, "protein_name": "Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial", "gene_name": "Ecsit", "organism": "Mouse", "refseq_name": "evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001240826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240826", "type": "external" } ], "gene_names_uniprotkb": "Ecsit; Sitpec", "gene_names_refseq": "Ecsit; Sitpec", "protein_names_uniprotkb": "Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Protein SITPEC", "protein_names_refseq": "ECSIT homolog; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; signaling intermediate in Toll pathway-evolutionarily conserved", "tax_id": 10090, "disease": "", "pathway": " (mmu:26940); (R-MMU-166058); (R-MMU-6799198); (R-MMU-975138); (R-MMU-975871)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "10465784;14633973;21750661;22588174;29291352;29514094;37152948", "class_list": "", "function": "Adapter protein that plays a role in different signaling pathways including TLRs and IL-1 pathways or innate antiviral induction signaling. Plays a role in the activation of NF-kappa-B by forming a signal complex with TRAF6 and TAK1/MAP3K7 to activate TAK1/MAP3K7 leading to activation of IKKs. Once ubiquitinated, interacts with the dissociated RELA and NFKB1 proteins and translocates to the nucleus where it induces NF-kappa-B-dependent gene expression. Plays a role in innate antiviral immune response by bridging the pattern recognition receptors RIGI and MDA5/IFIT1 to the MAVS complex at the mitochondrion. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; As part of the MCIA complex, involved in the assembly of the mitochondrial complex I., [UniProtKB, UniProtKB, UniProtKB, PubMed]; ECSIT is essential for RANKL-induced stimulation of mitochondria in osteoclasts and a target for the anti-osteoclastogenic effects of estrogens. Publication Status: Online-Only, [RefSeq, PubMed]; ECSIT-T419C knock-in mice showed higher peritoneal NADPH oxidase activity than mice with wild-type ECSIT in response to LPS. ECSIT-T419C-transfected ENKTL cell lines produced tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, which induced macrophage activation and massive cytokine secretion in cell culture and mouse xenografts., [RefSeq, PubMed]; Functions as an essential component in two important signal transduction pathways and establishes a novel role for Ecsit as a cofactor for Smad proteins in the bone morphogenetic protein signaling pathway, [RefSeq, PubMed]; These results demonstrate a key role of ECSIT in complex I function, mitochondrial reactive oxygen species production, and mitophagy-dependent mitochondrial quality control., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91V53", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0004857 enzyme inhibitor activity;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045087 innate immune response;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0030509 BMP signaling pathway;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QZH6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35137-1", "uniprot_id": [ { "id": "ALX4_MOUSE", "url": "https://www.uniprot.org/uniprot/O35137", "type": "external" } ], "mass": 42763.0, "length": 399, "protein_name": "Homeobox protein aristaless-like 4", "gene_name": "Alx4", "organism": "Mouse", "refseq_name": "homeobox protein aristaless-like 4", "refseq_ac": [ { "id": "NP_031468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031468", "type": "external" } ], "gene_names_uniprotkb": "Alx4", "gene_names_refseq": "Alx4; lst", "protein_names_uniprotkb": "Homeobox protein aristaless-like 4; ALX-4", "protein_names_refseq": "ALX-4; Aristaless-like 4; Strong's luxoid; aristaless 4; homeobox protein aristaless-like 4", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); parietal foramina (Disease Ontology:DOID:0060285); frontonasal dysplasia 2 (Disease Ontology:DOID:0081046); non-syndromic X-linked intellectual disability 1 (Disease Ontology:DOID:0112038); lung cancer (Disease Ontology:DOID:1324); craniosynostosis (Disease Ontology:DOID:2340); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung adenocarcinoma (Disease Ontology:DOID:3910); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:11695)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;9426253;9636085", "class_list": "", "function": "Transcription factor involved in skull and limb development., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0071837 HMG box domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007517 muscle organ development;GO:0009791 post-embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O35137-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH66-1", "uniprot_id": [ { "id": "ATLA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH66", "type": "external" } ], "mass": 63377.0, "length": 558, "protein_name": "Atlastin-1", "gene_name": "Atl1", "organism": "Mouse", "refseq_name": "atlastin-1", "refseq_ac": [ { "id": "NP_848743", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848743", "type": "external" } ], "gene_names_uniprotkb": "Atl1; Spg3a", "gene_names_refseq": "4930435M24Rik; Adfsp; Atl1; Fsp1; Spg3a; Spg3", "protein_names_uniprotkb": "Atlastin-1; 3.6.5.-; Spastic paraplegia 3A homolog", "protein_names_refseq": "atlastin-1; spastic paraplegia 3A homolog", "tax_id": 10090, "disease": "hereditary sensory neuropathy type 1D (Disease Ontology:DOID:0070156); hereditary spastic paraplegia 3A (Disease Ontology:DOID:0110791); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:73991)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "17242355;19665976;21183079;21750661;21913724;24668814;25428506;26984393;27669642;33300544;35348668", "class_list": "", "function": "Atlastin-1 (ATL1) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect. Two atlastin-1 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle. May also regulate more or less directly Golgi biogenesis (By similarity). Indirectly regulates axonal development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Endoplasmic reticulum morphology is markedly disrupted in ATL1, ATL2, and ATL3 knockout cells., [RefSeq, PubMed]; This gene encodes a member of the dynamin family of GTPases. The encoded protein interacts with tubule-shaping proteins of the endoplasmic reticulum. Mutations in the homologous human gene can cause hereditary spastic paraplegia. [provided by RefSeq, Feb 2010]., [RefSeq]; Transverse endoplasmic reticulum expansion in hereditary spastic paraplegia corticospinal axons., [RefSeq, PubMed]; VCP (valosin-containing protein), together with its cofactor P47 and the endoplasmic reticulum (ER) morphology regulator ATL1 (Atlastin-1), regulates tubular ER formation Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJH5", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0140523 GTPase-dependent fusogenic activity", "go_cellular_component": "GO:1990674 Golgi cis cisterna membrane;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007409 axonogenesis;GO:0051260 protein homooligomerization;GO:1990809 endoplasmic reticulum tubular network membrane organization;GO:0007029 endoplasmic reticulum organization;GO:0016320 endoplasmic reticulum membrane fusion", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BH66-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUL7-1", "uniprot_id": [ { "id": "ARL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUL7", "type": "external" } ], "mass": 20487.0, "length": 182, "protein_name": "ADP-ribosylation factor-like protein 3", "gene_name": "Arl3", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor-like protein 3 isoform 1", "refseq_ac": [ { "id": "NP_062692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062692", "type": "external" } ], "gene_names_uniprotkb": "Arl3", "gene_names_refseq": "Arl3", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 3", "protein_names_refseq": "ADP-ribosylation factor-like protein 3 isoform 1; ADP-ribosylation factor-like protein 3; ADP-ribosylation-like 3", "tax_id": 10090, "disease": "Joubert syndrome (Disease Ontology:DOID:0050777); retinitis pigmentosa 2 (Disease Ontology:DOID:0110415); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); retinitis pigmentosa 83 (Disease Ontology:DOID:0112140)", "pathway": " (mmu:56350); (R-MMU-5624138)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10518933;11188688;15979089;16565502;18376416;21750661;25405894;25428506;36598133;37507081", "class_list": "", "function": "Disrupting the ciliary gradient of active Arl3 affects rod photoreceptor nuclear migration. Publication Status: Online-Only, [RefSeq, PubMed]; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP) (PubMed:18376416). Required for normal cytokinesis and cilia signaling. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (By similarity). Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms (PubMed:15979089). Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (PubMed:25405894)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0015031 protein transport;GO:0001822 kidney development;GO:0007264 small GTPase-mediated signal transduction;GO:0060271 cilium assembly;GO:0000281 mitotic cytokinesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9WUL7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54320-1", "uniprot_id": [ { "id": "ELN_MOUSE", "url": "https://www.uniprot.org/uniprot/P54320", "type": "external" } ], "mass": 71938.0, "length": 860, "protein_name": "Elastin", "gene_name": "Eln", "organism": "Mouse", "refseq_name": "elastin precursor", "refseq_ac": [ { "id": "NP_031951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031951", "type": "external" } ], "gene_names_uniprotkb": "Eln", "gene_names_refseq": "E030024M20Rik; Eln", "protein_names_uniprotkb": "Elastin; Tropoelastin", "protein_names_refseq": "elastin precursor; tropoelastin", "tax_id": 10090, "disease": "pterygium (Disease Ontology:DOID:0002116); autosomal dominant cutis laxa 1 (Disease Ontology:DOID:0070130); polymyositis (Disease Ontology:DOID:0080745); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); Buschke-Ollendorff syndrome (Disease Ontology:DOID:0111536); pigmentation disease (Disease Ontology:DOID:10123); silicosis (Disease Ontology:DOID:10325); primary open angle glaucoma (Disease Ontology:DOID:1070); essential hypertension (Disease Ontology:DOID:10825); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); thromboangiitis obliterans (Disease Ontology:DOID:12918); temporal arteritis (Disease Ontology:DOID:13375); exfoliation syndrome (Disease Ontology:DOID:13641); bladder neck obstruction (Disease Ontology:DOID:13948); aortic valve stenosis (Disease Ontology:DOID:1712); melanoma (Disease Ontology:DOID:1909); Williams-Beuren syndrome (Disease Ontology:DOID:1928); supravalvular aortic stenosis (Disease Ontology:DOID:1929); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); cutis laxa (Disease Ontology:DOID:3144); photosensitivity disease (Disease Ontology:DOID:3159); aortic aneurysm (Disease Ontology:DOID:3627); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); liver cirrhosis (Disease Ontology:DOID:5082); aortic valve disease (Disease Ontology:DOID:62); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); dermatitis herpetiformis (Disease Ontology:DOID:8505); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); polyarteritis nodosa (Disease Ontology:DOID:9810)", "pathway": " (mmu:13717); (R-MMU-1474228); (R-MMU-1566948); (R-MMU-2129379)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "21750661;34203471;34428180;7829060;9607766", "class_list": "", "function": "Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle., [UniProtKB, PubMed]; This gene encodes elastin, the extracellular matrix protein that forms a major structural component of several tissues including lungs and arterial walls. Cleavage of the signal peptide from the encoded precursor generates soluble tropoelastin which undergoes lysine-derived crosslinking to form elastin polymers. Mice lacking the encoded protein exhibit defective lung development, and die of an obstructive arterial disease resulting from subendothelial cell proliferation and reorganization of smooth muscle. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 35, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C9L8", "ec_number_list": [], "go_molecular_function": "GO:0050840 extracellular matrix binding;GO:0030023 extracellular matrix constituent conferring elasticity;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0031012 extracellular matrix;GO:0071953 elastic fiber", "go_biological_process": "GO:0085029 extracellular matrix assembly;GO:0030198 extracellular matrix organization;GO:0001974 blood vessel remodeling;GO:0043149 stress fiber assembly;GO:0003151 outflow tract morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P54320-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52800-1", "uniprot_id": [ { "id": "EFNB2_MOUSE", "url": "https://www.uniprot.org/uniprot/P52800", "type": "external" } ], "mass": 37202.0, "length": 336, "protein_name": "Ephrin-B2", "gene_name": "Efnb2", "organism": "Mouse", "refseq_name": "ephrin-B2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_034241", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034241", "type": "external" } ], "gene_names_uniprotkb": "Efnb2; Elf2; Epl5; Eplg5; Htkl; Lerk5", "gene_names_refseq": "ELF-2; Efnb2; Epl5; Eplg5; Htk-L; LERK-5; Lerk5; NLERK-1", "protein_names_uniprotkb": "Ephrin-B2; ELF-2; EPH-related receptor tyrosine kinase ligand 5; HTK ligand; HTK-L; LERK-5", "protein_names_refseq": "EPH-related receptor tyrosine kinase ligand 5; HTK ligand; ephrin-B2 isoform 1 precursor", "tax_id": 10090, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); stomach cancer (Disease Ontology:DOID:10534); colon carcinoma (Disease Ontology:DOID:1520); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); varicose veins (Disease Ontology:DOID:799); nasopharynx carcinoma (Disease Ontology:DOID:9261); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (mmu:13642); (R-MMU-2682334); (R-MMU-3928662); (R-MMU-3928664); (R-MMU-3928665)", "pathway_count": 5, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;10704386;11703926;11780069;15096211;15240697;21183079;21750661;24129315;25428506;26495903;27446912;30084848;30639848;30899004;31219806;7534404;7651410;8559144", "class_list": "", "function": "Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0046875 ephrin receptor binding;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0099054 presynapse assembly;GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0008284 positive regulation of cell population proliferation;GO:0048013 ephrin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P52800-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TGW2-1", "uniprot_id": [ { "id": "EEPD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TGW2", "type": "external" } ], "mass": 62953.0, "length": 569, "protein_name": "Endonuclease/exonuclease/phosphatase family domain-containing protein 1", "gene_name": "Eepd1", "organism": "Mouse", "refseq_name": "endonuclease/exonuclease/phosphatase family domain-containing protein 1", "refseq_ac": [ { "id": "NP_080465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080465", "type": "external" } ], "gene_names_uniprotkb": "Eepd1; Kiaa1706", "gene_names_refseq": "2310005P05Rik; Eepd1", "protein_names_uniprotkb": "Endonuclease/exonuclease/phosphatase family domain-containing protein 1", "protein_names_refseq": "endonuclease/exonuclease/phosphatase family domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67484)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19144319;21183079;25428506;28082258;30084848;30779550;31219806;34428180;38924647", "class_list": "", "function": "EEPD1 is a novel LXR-regulated gene in macrophages and that it promotes cellular cholesterol efflux by controlling cellular levels and activity of ABCA1., [RefSeq, PubMed]; Obstructive Sleep Apnea Syndrome Exacerbates NASH Progression via Selective Autophagy-Mediated Eepd1 Degradation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZC7;Q8K3B5;Q9D7J3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006281 DNA repair;GO:0010875 positive regulation of cholesterol efflux", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q3TGW2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7J9-1", "uniprot_id": [ { "id": "ECHD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7J9", "type": "external" } ], "mass": 32402.0, "length": 300, "protein_name": "Enoyl-CoA hydratase domain-containing protein 3, mitochondrial", "gene_name": "Echdc3", "organism": "Mouse", "refseq_name": "enoyl-CoA hydratase domain-containing protein 3, mitochondrial precursor", "refseq_ac": [ { "id": "NP_077170", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077170", "type": "external" } ], "gene_names_uniprotkb": "Echdc3", "gene_names_refseq": "2310005D12Rik; Echdc3", "protein_names_uniprotkb": "Enoyl-CoA hydratase domain-containing protein 3, mitochondrial", "protein_names_refseq": "enoyl-CoA hydratase domain-containing protein 3, mitochondrial precursor; enoyl-CoA hydratase domain-containing protein 3, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:67856)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23806337;34428180;37507081", "class_list": "", "function": "May play a role in fatty acid biosynthesis and insulin sensitivity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99LV0", "ec_number_list": [], "go_molecular_function": "GO:0004300 enoyl-CoA hydratase activity;GO:0016836 hydro-lyase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:1900078 positive regulation of cellular response to insulin stimulus;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D7J9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCH4-1", "uniprot_id": [ { "id": "EIF3F_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCH4", "type": "external" } ], "mass": 37984.0, "length": 361, "protein_name": "Eukaryotic translation initiation factor 3 subunit F", "gene_name": "Eif3f", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 3 subunit F", "refseq_ac": [ { "id": "NP_079620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079620", "type": "external" } ], "gene_names_uniprotkb": "Eif3f; Eif3s5", "gene_names_refseq": "0610037M02Rik; Eif3f; Eif3s5", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit F; 3.4.19.12; Deubiquitinating enzyme eIF3f; Eukaryotic translation initiation factor 3 subunit 5; eIF-3-epsilon; eIF3 p47; eIF3f", "protein_names_refseq": "deubiquitinating enzyme eIF3f; eIF-3-epsilon; eIF3 p47; eukaryotic translation initiation factor 3 subunit F; eukaryotic translation initiation factor 3, subunit 5 (epsilon)", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 67 (Disease Ontology:DOID:0081228); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:66085); (R-MMU-156827); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706)", "pathway_count": 7, "publication_count": 16, "publication_id_list": "16541103;17581632;18354498;19073596;25605945;28135057;31026345;31209405;31219806;33300544;33725478;34428180;34887587;37453647;39627609;40997131", "class_list": "", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression., [UniProtKB, HAMAP]; Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling., [UniProtKB, PubMed, HAMAP]; EIF3f depletion impedes mouse embryonic development, reduces adult skeletal muscle mass and amplifies muscle loss during disuse., [RefSeq, PubMed]; Key target that accounts for E3 ubiquitin ligase MAFbx (atrogin1, Fbxo32) function during muscle atrophy; has a major role in skeletal muscle hypertrophy., [RefSeq, PubMed]; MAFbx/Atrogin-1 controls the activity of the initiation factor eIF3-f in skeletal muscle atrophy by targeting multiple C-terminal lysines., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5XJV3", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0003743 translation initiation factor activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0031369 translation initiation factor binding;GO:0140492 metal-dependent deubiquitinase activity", "go_cellular_component": "GO:0045202 synapse;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0075522 IRES-dependent viral translational initiation;GO:0006508 proteolysis;GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9DCH4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64693-1", "uniprot_id": [ { "id": "OBF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64693", "type": "external" } ], "mass": 27692.0, "length": 256, "protein_name": "POU domain class 2-associating factor 1", "gene_name": "Pou2af1", "organism": "Mouse", "refseq_name": "POU domain class 2-associating factor 1", "refseq_ac": [ { "id": "NP_035266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035266", "type": "external" } ], "gene_names_uniprotkb": "Pou2af1; Obf-1", "gene_names_refseq": "BOB.1; Bob-1; Bob1; OBF-1; OBF.1; OCA-B; OCAB; Pou2af1", "protein_names_uniprotkb": "POU domain class 2-associating factor 1; B-cell-specific coactivator OBF-1; BOB-1; BOB1; OCA-B; OCT-binding factor 1", "protein_names_refseq": "B-cell-specific coactivator OBF-1; OCT-binding factor 1; POU domain class 2-associating factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18985)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "18299400;20173027;21750661;23045607;27802388;30084848;30779550;34428180;35603192;35820727;38360857;38386711;8183884;8530384;8657574;8868069", "class_list": "", "function": "Bob1 maintains T follicular helper cells for long-term humoral immunity. Publication Status: Online-Only, [RefSeq, PubMed]; OCA-B/Pou2af1 is sufficient to promote CD4[+] T cell memory and prospectively identifies memory precursors. Erratum:[Proc Natl Acad Sci U S A. 2024 Apr 16;121(16):e2405830121. doi: 10.1073/pnas.2405830121. PMID: 38588436], [RefSeq, PubMed]; T Cell Specific BOB.1/OBF.1 Expression Promotes Germinal Center Response and T Helper Cell Differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2. It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2. It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers (PubMed:23045607). Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator (PubMed:23045607)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0070974 POU domain binding", "go_cellular_component": "GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032755 positive regulation of interleukin-6 production;GO:0002314 germinal center B cell differentiation;GO:0098586 cellular response to virus", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q64693-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JI99-1", "uniprot_id": [ { "id": "SGPP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JI99", "type": "external" } ], "mass": 47744.0, "length": 430, "protein_name": "Sphingosine-1-phosphate phosphatase 1", "gene_name": "Sgpp1", "organism": "Mouse", "refseq_name": "sphingosine-1-phosphate phosphatase 1", "refseq_ac": [ { "id": "NP_109675", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109675", "type": "external" } ], "gene_names_uniprotkb": "Sgpp1; Spp1; Spph1", "gene_names_refseq": "SPP1; SPP; Sgpp1; Spph1", "protein_names_uniprotkb": "Sphingosine-1-phosphate phosphatase 1; 3.1.3.-; SPPase1; SPP; Sphingosine-1-phosphatase 1; mSPP1", "protein_names_refseq": "SPPase1; sphingosine-1-phosphatase 1; sphingosine-1-phosphate phosphatase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:81535); (R-MMU-9845614)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10859351;11756451;12235122;12411432;12815058;17114649;17242355;17895250;19131326;21183079;21750661;23637227;25428506;27869314;30084848;34428180", "class_list": "", "function": "Data indicate that sphingosine-1-phosphate phosphatases 1 (Sgpp1) deficiency in keratinocytes causes sphingosine-1-phosphate (S1P) elevation and accelerates their differentiation., [RefSeq, PubMed]; Regulation of sphingolipid metabolism and apoptosis by SPP1, [RefSeq, PubMed]; Results show that Runx1 regulates glucocorticoid sensitivity in lymphoma cells and identify an established direct target gene, Sgpp1, as an integrator of sphingolipid metabolism and responses to glucocorticoids., [RefSeq, PubMed]; Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P (PubMed:10859351, PubMed:11756451). Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid. Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway. Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger (PubMed:10859351, Ref.2). Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase (PubMed:12235122, PubMed:17895250). In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (PubMed:17895250). Regulates endoplasmic-to-Golgi trafficking of ceramides, resulting in the regulation of ceramide levels in the endoplasmic reticulum, preferentially long-chain ceramide species, and influences the anterograde membrane transport of both ceramide and proteins from the endoplasmic reticulum to the Golgi apparatus (By similarity). The modulation of intracellular ceramide levels in turn regulates apoptosis (PubMed:12235122). Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries. Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels (By similarity). Involved in the regulation of epidermal homeostasis and keratinocyte differentiation (PubMed:23637227)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Sphingosine-1-phosphate phosphatase 1 plays roles in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "3.1.3.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106", "type": "external" }, { "id": "3.6.1.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75", "type": "external" } ], "go_molecular_function": "GO:0070780 dihydrosphingosine-1-phosphate phosphatase activity;GO:0042392 sphingosine-1-phosphate phosphatase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006670 sphingosine metabolic process;GO:0006665 sphingolipid metabolic process;GO:0097191 extrinsic apoptotic signaling pathway;GO:0097193 intrinsic apoptotic signaling pathway;GO:0045616 regulation of keratinocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9JI99-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TTP0-1", "uniprot_id": [ { "id": "SHP1L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TTP0", "type": "external" } ], "mass": 70948.0, "length": 639, "protein_name": "Testicular spindle-associated protein SHCBP1L", "gene_name": "Shcbp1l", "organism": "Mouse", "refseq_name": "testicular spindle-associated protein SHCBP1L", "refseq_ac": [ { "id": "NP_001028334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028334", "type": "external" } ], "gene_names_uniprotkb": "Shcbp1l", "gene_names_refseq": "1700012A16Rik; Shcbp1l", "protein_names_uniprotkb": "Testicular spindle-associated protein SHCBP1L; SHC SH2 domain-binding protein 1-like protein", "protein_names_refseq": "SHC SH2 domain-binding protein 1-like protein; testicular spindle-associated protein SHCBP1L", "tax_id": 10090, "disease": "", "pathway": " (mmu:71836)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;24557841", "class_list": "", "function": "Testis-specific spindle-associated factor that plays a role in spermatogenesis (PubMed:24557841). In association with HSPA2, participates in the maintenance of spindle integrity during meiosis in male germ cells (PubMed:24557841)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0072687 meiotic spindle", "go_biological_process": "GO:2001252 positive regulation of chromosome organization;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0007112 male meiosis cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3TTP0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61165-1", "uniprot_id": [ { "id": "SL9A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61165", "type": "external" } ], "mass": 91468.0, "length": 820, "protein_name": "Sodium/hydrogen exchanger 1", "gene_name": "Slc9a1", "organism": "Mouse", "refseq_name": "sodium/hydrogen exchanger 1 isoform 1", "refseq_ac": [ { "id": "NP_058677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058677", "type": "external" } ], "gene_names_uniprotkb": "Slc9a1; Nhe1", "gene_names_refseq": "Apnh; Mir5122; Nhe1; Slc9a1; mir-5122; swe", "protein_names_uniprotkb": "Sodium/hydrogen exchanger 1; NHE-1; Na(+)/H(+) exchanger 1; Solute carrier family 9 member 1", "protein_names_refseq": "NHE-1; Na(+)/H(+) exchanger 1; Na+/H+ antiporter; Na+/H+, amiloride sensitive; slow-wave epilepsy; sodium/hydrogen exchanger 1 isoform 1; sodium/hydrogen exchanger 1; solute carrier family 9, member 1", "tax_id": 10090, "disease": "autosomal recessive spinocerebellar ataxia 19 (Disease Ontology:DOID:0080065); hypothyroidism (Disease Ontology:DOID:1459); renovascular hypertension (Disease Ontology:DOID:1591); middle cerebral artery infarction (Disease Ontology:DOID:3525); proteinuria (Disease Ontology:DOID:576); congestive heart failure (Disease Ontology:DOID:6000); hyperthyroidism (Disease Ontology:DOID:7998); cataract (Disease Ontology:DOID:83); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:20544); (R-MMU-2160916); (R-MMU-425986)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;10199808;11931388;17114649;17242355;19131326;19144319;19369449;21183079;25428506;25605945;26495903;30084848;30899004;33585583;34428180;38509618;39118129;9335342", "class_list": "", "function": "Acidic preconditioning induced intracellular acid adaptation to protect renal injury via dynamic phosphorylation of focal adhesion kinase-dependent activation of sodium hydrogen exchanger 1. Erratum:[Cell Commun Signal. 2024 Sep 11;22(1):439. doi: 10.1186/s12964-024-01815-3. PMID: 39261884] Publication Status: Online-Only, [RefSeq, PubMed]; Deletion of Slc9a1 in Cx3cr1[+] cells stimulated microglial subcluster CREB1 signaling and microglia-oligodendrocyte crosstalk. Publication Status: Online-Only, [RefSeq, PubMed]; Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (By similarity). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival. In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter. SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 9, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0015386 potassium:proton antiporter activity;GO:0005516 calmodulin binding;GO:0005543 phospholipid binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0070417 cellular response to cold;GO:0086003 cardiac muscle cell contraction;GO:0086092 regulation of the force of heart contraction by cardiac conduction;GO:0030307 positive regulation of cell growth;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q61165-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80U12-1", "uniprot_id": [ { "id": "SGSM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80U12", "type": "external" } ], "mass": 113076.0, "length": 1005, "protein_name": "Small G protein signaling modulator 2", "gene_name": "Sgsm2", "organism": "Mouse", "refseq_name": "small G protein signaling modulator 2 isoform 1", "refseq_ac": [ { "id": "NP_922934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_922934", "type": "external" } ], "gene_names_uniprotkb": "Sgsm2; Kiaa0397; Rutbc1", "gene_names_refseq": "D630003G22Rik; Rutbc1; Sgsm2; mKIAA0397", "protein_names_uniprotkb": "Small G protein signaling modulator 2; RUN and TBC1 domain-containing protein 1", "protein_names_refseq": "RUN and TBC1 domain containing 1; RUN and TBC1 domain-containing protein 1; small G protein signaling modulator 2 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:97761)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "17509819;21183079;25428506;25605945;26620560;30084848;30679156;31219806;34203471;34418053;34428180", "class_list": "", "function": "Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed:26620560)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5SWE0;Q5SWE1;Q6PAP8", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0042470 melanosome", "go_biological_process": "GO:0034499 late endosome to Golgi transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q80U12-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZE3-1", "uniprot_id": [ { "id": "SIG10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80ZE3", "type": "external" } ], "mass": 76884.0, "length": 688, "protein_name": "Sialic acid-binding Ig-like lectin 10", "gene_name": "Siglec10", "organism": "Mouse", "refseq_name": "sialic acid-binding Ig-like lectin 10 isoform 1 precursor", "refseq_ac": [ { "id": "NP_766488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766488", "type": "external" } ], "gene_names_uniprotkb": "Siglec10; Siglecg", "gene_names_refseq": "9830164H23; A630096C01Rik; Siglec-G; Siglec10; Siglecg; mSiglec-G", "protein_names_uniprotkb": "Sialic acid-binding Ig-like lectin 10; Sialic acid-binding Ig-like lectin G; Siglec-10; Siglec-G; mSiglec-G", "protein_names_refseq": "sialic acid binding Ig-like lectin 10; sialic acid-binding Ig-like lectin 10 isoform 1 precursor; siglec-10", "tax_id": 10090, "disease": "", "pathway": " (mmu:243958); (R-MMU-198933); (R-MMU-2172127)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;14559209;17572677;17912374;19264983;20038598;20200274;23374343;23836061;24790146;27548433;34428180;36969253;38042621;39627609", "class_list": "glycogene", "function": "(Microbial infection) During infection by RNA viruses inhibits RIG-I signaling in macrophages by promoting its CBL-dependent ubiquitination and degradation via PTPN11/SHP-2., [UniProtKB, PubMed]; Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus. Publication Status: Online-Only, [RefSeq, PubMed]; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (PubMed:20038598). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (By similarity). Involved in negative regulation of B-cell antigen receptor signaling and specifically acts on B1 cells to inhibit Ca(2+) signaling, cellular expansion and antibody secretion (PubMed:17572677). The inhibition of B cell activation is dependent on PTPN6/SHP-1 (PubMed:23836061). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (PubMed:19264983). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (By similarity). Plays a role in the control of autoimmunity (PubMed:20200274). During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (PubMed:27548433)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Results reveal that the CD24-Siglec G pathway protects the host against a lethal response to pathological cell death and discriminates danger- versus pathogen-associated molecular patterns, [RefSeq, PubMed]; Siglec G-NFkappaB pathway has a critical role in regulating B1a B cell lineage Publication Status: Online-Only, [RefSeq, PubMed]; Siglec-G-dependent negative regulation exists in B1 cells., [RefSeq, PubMed]; The role of Siglec-G on B cells in autoimmune disease and leukemia., [RefSeq, PubMed]; We detected expression of mSiglec-5 (or -F), -10, and -E mRNA in purified mouse eosinophils, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 52, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0033691 sialic acid binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050849 negative regulation of calcium-mediated signaling;GO:0007155 cell adhesion;GO:0045087 innate immune response;GO:0050776 regulation of immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q80ZE3-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100000010001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61753-1", "uniprot_id": [ { "id": "SERA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61753", "type": "external" } ], "mass": 56586.0, "length": 533, "protein_name": "D-3-phosphoglycerate dehydrogenase", "gene_name": "Phgdh", "organism": "Mouse", "refseq_name": "D-3-phosphoglycerate dehydrogenase", "refseq_ac": [ { "id": "NP_058662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058662", "type": "external" } ], "gene_names_uniprotkb": "Phgdh", "gene_names_refseq": "3-PGDH; 3PGDH; 4930479N23; A10; PGAD; PGDH; PGD; Phgdh; SERA", "protein_names_uniprotkb": "D-3-phosphoglycerate dehydrogenase; 1.1.1.95; 3-PGDH; A10", "protein_names_refseq": "3-phosphoglycerate dehyrogenase; D-3-phosphoglycerate dehydrogenase", "tax_id": 10090, "disease": "PHGDH deficiency (Disease Ontology:DOID:0050722); Neu-Laxova syndrome 1 (Disease Ontology:DOID:0080076); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (mmu:236539); (R-MMU-977347)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "14645240;19114063;19892989;20173027;21183079;21540332;21750661;22645316;23806337;24788674;25428506;25605945;29187734;30084848;30779550;31599954;34428180;34887587;36210013;37507081;37828378;39627609", "class_list": "", "function": "Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Does not catalyze the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEE5;Q75SV9;Q8C603", "ec_number_list": [ { "id": "1.1.1.95", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.95", "type": "external" } ], "go_molecular_function": "GO:0051287 NAD binding;GO:0004617 phosphoglycerate dehydrogenase activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043209 myelin sheath", "go_biological_process": "GO:0021782 glial cell development;GO:0021510 spinal cord development;GO:0031175 neuron projection development;GO:0021915 neural tube development;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q61753-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60670-1", "uniprot_id": [ { "id": "SIK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60670", "type": "external" } ], "mass": 85115.0, "length": 779, "protein_name": "Serine/threonine-protein kinase SIK1", "gene_name": "Sik1", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase SIK1", "refseq_ac": [ { "id": "NP_034961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034961", "type": "external" } ], "gene_names_uniprotkb": "Sik1; Msk; Sik; Snf1lk", "gene_names_refseq": "Hrt-20; Msk; Sik-1; Sik1; Sik; Snf1lk", "protein_names_uniprotkb": "Serine/threonine-protein kinase SIK1; 2.7.11.1; HRT-20; Myocardial SNF1-like kinase; SIK-1; Salt-inducible kinase 1; Serine/threonine-protein kinase SNF1-like kinase 1; Serine/threonine-protein kinase SNF1LK", "protein_names_refseq": "Probable serine/threonine protein kinase SNF1LK (HRT-20) (Myocardial SNF1-like kinase); myocardial SNF1-like kinase; salt-inducible protein kinase 1; serine/threonine-protein kinase SIK1; serine/threonine-protein kinase SNF1-like kinase 1; serine/threonine-protein kinase SNF1LK", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 30 (Disease Ontology:DOID:0080465)", "pathway": " (mmu:17691)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "12200423;12943728;15177563;15511237;16148943;16817901;17468767;18946175;19244231;19622832;20140255;23993098;32457359;32599076;34428180;35887274;36210013;36434056;7893599", "class_list": "", "function": "An Epilepsy-Associated Mutation of Salt-Inducible Kinase 1 Increases the Susceptibility to Epileptic Seizures and Interferes with Adrenocorticotropic Hormone Therapy for Infantile Spasms in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Salt-inducible kinase 1-CREB-regulated transcription coactivator 1 signalling in the paraventricular nucleus of the hypothalamus plays a role in depression by regulating the hypothalamic-pituitary-adrenal axis., [RefSeq, PubMed]; Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UR46", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010830 regulation of myotube differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0002028 regulation of sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q60670-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CE50-1", "uniprot_id": [ { "id": "SNX30_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CE50", "type": "external" } ], "mass": 49520.0, "length": 437, "protein_name": "Sorting nexin-30", "gene_name": "Snx30", "organism": "Mouse", "refseq_name": "sorting nexin-30", "refseq_ac": [ { "id": "NP_766056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766056", "type": "external" } ], "gene_names_uniprotkb": "Snx30", "gene_names_refseq": "4732481H14Rik; C030041J06Rik; Snx30", "protein_names_uniprotkb": "Sorting nexin-30", "protein_names_refseq": "novel PX domain containing protein; sorting nexin-30", "tax_id": 10090, "disease": "", "pathway": " (mmu:209131)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;25428506;34428180", "class_list": "", "function": "Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Together with SNX4, involved in autophagosome assembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UHE6", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005769 early endosome;GO:0031901 early endosome membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0015031 protein transport;GO:0000423 mitophagy;GO:0032456 endocytic recycling;GO:0034727 piecemeal microautophagy of the nucleus;GO:0061709 reticulophagy", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CE50-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CI08-1", "uniprot_id": [ { "id": "SLAI2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CI08", "type": "external" } ], "mass": 62378.0, "length": 581, "protein_name": "SLAIN motif-containing protein 2", "gene_name": "Slain2", "organism": "Mouse", "refseq_name": "SLAIN motif-containing protein 2 isoform b", "refseq_ac": [ { "id": "NP_001106894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106894", "type": "external" } ], "gene_names_uniprotkb": "Slain2; Kiaa1458", "gene_names_refseq": "5033405K12Rik; 8030444K12Rik; Slain2", "protein_names_uniprotkb": "SLAIN motif-containing protein 2", "protein_names_refseq": "SLAIN motif-containing protein 2 isoform b; SLAIN motif-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:75991)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19144319;21183079;21646404;21750661;22872234;23077057;24129315;25428506;30084848;30779550;31219806;34428180;36288343;37741612;37817544", "class_list": "", "function": "Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase., [UniProtKB, PubMed]; Circ-Slain2 Alleviates Cartilage Degradation and Inflammation of TMJOA., [RefSeq, PubMed]; Results identify SLAIN2 as a key component of microtubule plus end interaction networks., [RefSeq, PubMed]; SLAIN2 is expressed throughout development and is highly enriched in brain., [RefSeq, PubMed]; Slain2 attenuates brain injury following subarachnoid hemorrhage by controlling axonal microtubule structure in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q05DK1;Q3UJI9;Q6ZPQ5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0036064 ciliary basal body;GO:0035371 microtubule plus-end", "go_biological_process": "GO:0031113 regulation of microtubule polymerization;GO:0007020 microtubule nucleation;GO:0031116 positive regulation of microtubule polymerization;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q8CI08-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LM3-1", "uniprot_id": [ { "id": "SMTL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LM3", "type": "external" } ], "mass": 49525.0, "length": 459, "protein_name": "Smoothelin-like protein 1", "gene_name": "Smtnl1", "organism": "Mouse", "refseq_name": "smoothelin-like protein 1", "refseq_ac": [ { "id": "NP_077192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077192", "type": "external" } ], "gene_names_uniprotkb": "Smtnl1", "gene_names_refseq": "1110030K22Rik; CHASM; Smtnl1", "protein_names_uniprotkb": "Smoothelin-like protein 1; CHASM; Calponin homology-associated smooth muscle protein", "protein_names_refseq": "calponin homology-associated smooth muscle protein; smoothelin-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68678)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15327999;18310078;18477568;20627103;20634291;28320308;30679490;34675885;35508278;35820727;36342379;38883605", "class_list": "", "function": "An interaction between CHASM and tropomyosin, is demonstrated., [RefSeq, PubMed]; CHASM is a novel member of the smoothelin protein family that elicits Ca2+ desensitization in smooth muscle, [RefSeq, PubMed]; Deletion of SMTNL1 contributes to enhancement of pressure-induced contractility of mesenteric resistance vessels by influencing the activity of myosin phosphatase. Publication Status: Online-Only, [RefSeq, PubMed]; Findings define a new conserved pathway in which sexual development and pregnancy mediate smooth and striated muscle adaptations through SMTNL1 and MYPT1., [RefSeq, PubMed]; Mechanisms by which smoothelin-like protein 1 reverses insulin resistance in myotubules and mice., [RefSeq, PubMed]; Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-301 reduces this inhibitory activity., [UniProtKB, PubMed, PubMed]; Revealed a close interaction of SMTNL1-homology with the two Ca(2+) binding loop regions of the C-terminal domain of apo-calmodulin, [RefSeq, PubMed]; SMTNL1 has roles in cGMP/cAMP-mediated adaptations to exercise through mechanisms involving direct modulation of contractile activity GeneRIF: A knock out mouse for this gene shows an exercise adapted phenotype. The encoded protein has a unique expression profile in striated muscle both in mice and human., [RefSeq, PubMed]; Smoothelin-Like Protein 1 Regulates Development and Metabolic Transformation of Skeletal Muscle in Hyperthyroidism. Publication Status: Online-Only, [RefSeq, PubMed]; Smoothelin-like 1 knockout mice display sex-dependent alterations in blood flow and cardiac function., [RefSeq, PubMed]; Smoothelin-like protein 1 promotes insulin sensitivity and modulates the contractile properties of endometrial epithelial cells with insulin resistance. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017020 myosin phosphatase regulator activity;GO:0005516 calmodulin binding;GO:0008157 protein phosphatase 1 binding;GO:0097718 disordered domain specific binding;GO:0005523 tropomyosin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031674 I band;GO:0031430 M band;GO:0043292 contractile muscle fiber", "go_biological_process": "GO:0045892 negative regulation of DNA-templated transcription;GO:0030036 actin cytoskeleton organization;GO:0045907 positive regulation of vasoconstriction;GO:0042310 vasoconstriction;GO:0014823 response to activity", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99LM3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWK8-1", "uniprot_id": [ { "id": "SNX2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWK8", "type": "external" } ], "mass": 58471.0, "length": 519, "protein_name": "Sorting nexin-2", "gene_name": "Snx2", "organism": "Mouse", "refseq_name": "sorting nexin-2 isoform 1", "refseq_ac": [ { "id": "NP_080662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080662", "type": "external" } ], "gene_names_uniprotkb": "Snx2", "gene_names_refseq": "0610030A03Rik; Snx2", "protein_names_uniprotkb": "Sorting nexin-2", "protein_names_refseq": "sorting nexin-2 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67804); (R-MMU-432722)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "12388759;16214895;17242355;21183079;21750661;25183008;29187734;34428180;37507081;39627609;40885482", "class_list": "", "function": "BLOS1 interacts with sorting nexin 2 and the ESCRT-I component TSG101 to mediate the sorting of EGFR into endosomal compartments, [RefSeq, PubMed]; Data describe a functional interaction between Hbeta58, sorting nexin 1 (SNX1), and SNX2 and strongly suggest that SNX2 plays a more critical role than SNX1 in retromer activity during embryonic development., [RefSeq, PubMed]; Data show that mice lacking sorting nexin 1 or sorting nexin 2 are viable and fertile, whereas embryos deficient in both proteins arrest at midgestation., [RefSeq, PubMed]; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Required for retrograde endosome-to-TGN transport of TGN38. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKW3;Q9CQV0", "ec_number_list": [], "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0005154 epidermal growth factor receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0016020 membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0072673 lamellipodium morphogenesis;GO:0042147 retrograde transport, endosome to Golgi;GO:0034498 early endosome to Golgi transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9CWK8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K424-1", "uniprot_id": [ { "id": "TRPV3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K424", "type": "external" } ], "mass": 90663.0, "length": 791, "protein_name": "Transient receptor potential cation channel subfamily V member 3", "gene_name": "Trpv3", "organism": "Mouse", "refseq_name": "transient receptor potential cation channel subfamily V member 3 isoform 1", "refseq_ac": [ { "id": "NP_659567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659567", "type": "external" } ], "gene_names_uniprotkb": "Trpv3", "gene_names_refseq": "1110036I10Rik; Nh; Trpv3; VRL3", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily V member 3; TrpV3", "protein_names_refseq": "TRP ion channel TRPV3; non-hair; transient receptor potential cation channel subfamily V member 3 isoform 1", "tax_id": 10090, "disease": "congenital stationary night blindness (Disease Ontology:DOID:0050534); focal nonepidermolytic palmoplantar keratoderma 2 (Disease Ontology:DOID:0111711); autosomal dominant mutilating palmoplantar keratoderma with periorificial keratotic plaques (Disease Ontology:DOID:0112013); migraine with aura (Disease Ontology:DOID:10024); dermatitis (Disease Ontology:DOID:2723); atopic dermatitis (Disease Ontology:DOID:3310); schizophrenia (Disease Ontology:DOID:5419); rosacea (Disease Ontology:DOID:8881); colorectal cancer (Disease Ontology:DOID:9256); alopecia (Disease Ontology:DOID:987)", "pathway": " (mmu:246788); (R-MMU-3295583)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12016205;25428506;37855862;38365607;38648901;38777204", "class_list": "", "function": "Aging is associated with impaired triggering of TRPV3-mediated cutaneous vasodilation: a crucial process for local heat exposure., [RefSeq, PubMed]; Non-selective calcium permeant cation channel (PubMed:12016205). It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius (By similarity). Activation exhibits an outward rectification (By similarity). The channel pore can dilate to provide permeability to larger cations (By similarity). May associate with TRPV1 and may modulate its activity (By similarity). Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity)., [UniProtKB, PubMed, UniProtKB]; Specifically expressed in keratinocytes;hence,skin cells are capable of detecting heat via molecules similar to those in heat-sensing neurons, [RefSeq, PubMed]; TRPV3 facilitates lipolysis and attenuates diet-induced obesity via activation of the NRF2/FSP1 signaling axis., [RefSeq, PubMed]; TRPV3 promotes sebocyte inflammation via transcriptional modulating TLR2 in acne., [RefSeq, PubMed]; Whole genome sequencing analysis of alpaca suggests TRPV3 as a candidate gene for the suri phenotype. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SV08", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0005262 calcium channel activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0016020 membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007231 osmosensory signaling pathway;GO:0007015 actin filament organization;GO:0009266 response to temperature stimulus;GO:0090280 positive regulation of calcium ion import;GO:0098703 calcium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K424-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWU2-1", "uniprot_id": [ { "id": "ZDH13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWU2", "type": "external" } ], "mass": 70890.0, "length": 622, "protein_name": "Palmitoyltransferase ZDHHC13", "gene_name": "Zdhhc13", "organism": "Mouse", "refseq_name": "palmitoyltransferase ZDHHC13", "refseq_ac": [ { "id": "NP_082307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082307", "type": "external" } ], "gene_names_uniprotkb": "Zdhhc13; Hip14l", "gene_names_refseq": "2410004E01Rik; C530010M18; HIP3RP; Hip14l; Zdhhc13; kojak; skc4", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC13; 2.3.1.225; DHHC-13; HIP14-related protein; Huntingtin-interacting protein 14-related protein; Zinc finger DHHC domain-containing protein 13", "protein_names_refseq": "DHHC-13; HIP14-related protein; huntingtin-interacting protein 14-related protein; palmitoyltransferase ZDHHC13; probable palmitoyltransferase ZDHHC13; zinc finger DHHC domain-containing protein 13", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (mmu:243983)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "18794299;19299482;20548961;21750661;25253725;25428506;26198635;28882895;29038583;30084848;31219806;31669413;34428180", "class_list": "", "function": "Huntingtin interacting protein genes, HIP14 and HIP14L, encode Mg2+ transport proteins that are regulated by their innate palmitoyl acyltransferases thus fulfilling the characteristics of 'chanzymes.', [RefSeq, PubMed]; Palmitoyl Acyltransferase Activity of ZDHHC13 Regulates Skin Barrier Development Partly by Controlling PADi3 and TGM1 Protein Stability., [RefSeq, PubMed]; Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (PubMed:18794299, PubMed:19299482). Palmitoyltransferase for HTT and GAD2 (PubMed:19299482, PubMed:20548961). May play a role in Mg(2+) transport (PubMed:18794299)., [UniProtKB, PubMed, PubMed]; Zdhhc13-dependent Drp1 S-palmitoylation, which acting alone or in concert, enables the normal occurrence of the fission-fusion process. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UK32;Q3UKV1", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0015095 magnesium ion transmembrane transporter activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030660 Golgi-associated vesicle membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9CWU2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10761-1", "uniprot_id": [ { "id": "ZP3_MOUSE", "url": "https://www.uniprot.org/uniprot/P10761", "type": "external" } ], "mass": 46304.0, "length": 424, "protein_name": "Zona pellucida sperm-binding protein 3", "gene_name": "Zp3", "organism": "Mouse", "refseq_name": "zona pellucida sperm-binding protein 3 preproprotein", "refseq_ac": [ { "id": "NP_035906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035906", "type": "external" } ], "gene_names_uniprotkb": "Zp3; Zp-3; Zpc", "gene_names_refseq": "Zp-3; Zp3", "protein_names_uniprotkb": "Zona pellucida sperm-binding protein 3; Sperm receptor; Zona pellucida glycoprotein 3; Zona pellucida protein C; Zp-3", "protein_names_refseq": "sperm receptor; zona pellucida glycoprotein ZP3; zona pellucida protein C; zona pellucida sperm-binding protein 3 preproprotein; zona pellucida sperm-binding protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:22788); (R-MMU-2534343)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "10456839;10713085;10799886;12589785;12799386;1330788;1370297;14673092;16401092;19052627;21730109;21750661;2541416;2842770;3378665;35017645;7491811;7561067;7594562;7650399;8227327;8617983;9600940", "class_list": "", "function": "Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation., [UniProtKB, UniProtKB, UniProtKB]; Transglutaminase 2 crosslinks zona pellucida glycoprotein 3 to prevent polyspermy., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 5, "mined_n_glycosites": 1, "mined_o_glycosites": 4, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 9, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 83, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q4FZI2", "ec_number_list": [], "go_molecular_function": "GO:0035804 structural constituent of egg coat;GO:0032190 acrosin binding;GO:0042802 identical protein binding;GO:0030246 carbohydrate binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0035805 egg coat", "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:2000386 positive regulation of ovarian follicle development;GO:0035803 egg coat formation;GO:0007339 binding of sperm to zona pellucida;GO:0002455 humoral immune response mediated by circulating immunoglobulin", "synthesized_glycan_count": 0, "hit_score": 11.6, "record_id": "P10761-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100110001000.111.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17012-1", "uniprot_id": [ { "id": "ZFX_MOUSE", "url": "https://www.uniprot.org/uniprot/P17012", "type": "external" } ], "mass": 90026.0, "length": 799, "protein_name": "Zinc finger X-chromosomal protein", "gene_name": "Zfx", "organism": "Mouse", "refseq_name": "zinc finger X-chromosomal protein isoform 1", "refseq_ac": [ { "id": "NP_001037851", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037851", "type": "external" } ], "gene_names_uniprotkb": "Zfx", "gene_names_refseq": "6; Zfx5; Zfx6; Zfx", "protein_names_uniprotkb": "Zinc finger X-chromosomal protein", "protein_names_refseq": "X-linked zinc finger protein; zinc finger X-chromosomal protein isoform 1; zinc finger X-chromosomal protein; zinc finger protein X-linked 5; zinc finger protein X-linked 6", "tax_id": 10090, "disease": "syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309)", "pathway": " (mmu:22764)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19144319;2105457;21183079;21750661;28251288;34203471;34324278;38310188;38602753;8188262", "class_list": "", "function": "Blockade of ZFX Alleviates Hypoxia-Induced Pulmonary Vascular Remodeling by Regulating the YAP Signaling., [RefSeq, PubMed]; Circ_0000520 contributes to triple-negative breast cancer progression through mediating the miR-1296/ZFX axis., [RefSeq, PubMed]; Our findings show that RNAi-mediated disruption of Zfx/Zfy in mouse testis affected X/Y spermatogenesis. Additionally, results suggest that the paralogous genes Zfx/Zfy play an important role in the process of X and Y sperm development. The individual interference of Zfx/Zfy may predict the outcome of X and Y haploid sperms. Presented herein is an advanced method developed to control mouse X/Y spermatogenesis and sex rati, [RefSeq, PubMed]; Probable transcriptional activator., [UniProtKB, UniProtKB]; [Expression of Zfx in mouse testicular spermatogenic cells]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P17011", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000785 chromatin", "go_biological_process": "GO:0060746 parental behavior;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0009566 fertilization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P17012-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62700-1", "uniprot_id": [ { "id": "YPEL5_MOUSE", "url": "https://www.uniprot.org/uniprot/P62700", "type": "external" } ], "mass": 13842.0, "length": 121, "protein_name": "Protein yippee-like 5", "gene_name": "Ypel5", "organism": "Mouse", "refseq_name": "protein yippee-like 5 isoform 1", "refseq_ac": [ { "id": "NP_081442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081442", "type": "external" } ], "gene_names_uniprotkb": "Ypel5", "gene_names_refseq": "2310076K21Rik; CGI-127; Ypel5", "protein_names_uniprotkb": "Protein yippee-like 5", "protein_names_refseq": "protein yippee-like 5 isoform 1; protein yippee-like 5; yippee protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:383295); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21183079;21750661;25605945;27705791;31219806;34428180", "class_list": "", "function": "Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Required for normal cell proliferation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Ypel5 is a negative regulator of IFNB1 production and innate immune responses that interacts functionally and physically with TBK1/IKBKE kinases, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543T4;Q8R174;Q9D6M1;Q9UMX7;Q9Y3C9", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0030496 midbody;GO:0000151 ubiquitin ligase complex;GO:0097431 mitotic spindle pole", "go_biological_process": "GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P62700-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0GGX2-1", "uniprot_id": [ { "id": "ZN541_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0GGX2", "type": "external" } ], "mass": 148297.0, "length": 1363, "protein_name": "Zinc finger protein 541", "gene_name": "Znf541", "organism": "Mouse", "refseq_name": "zinc finger protein 541 isoform 2", "refseq_ac": [ { "id": "NP_001092747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092747", "type": "external" } ], "gene_names_uniprotkb": "Znf541; Ship1; Zfp541", "gene_names_refseq": "EG666528; Zfp541; Znf541", "protein_names_uniprotkb": "Zinc finger protein 541; Spermatogenic cell HDAC-interacting protein 1", "protein_names_refseq": "spermatogenic cell HDAC-interacting protein 1; zinc finger protein 541 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:666528)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17662146;18849567;25428506;33961623;34075040;35320728;35341968;35820727;37921559", "class_list": "", "function": "KCTD19 and its associated protein ZFP541 are independently essential for meiosis in male mice. Publication Status: Online-Only, [RefSeq, PubMed]; Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; The Mm.290718/ZFP541 complex is implicated in chromatin remodeling during spermatogenesis and is renamed SHIP1, [RefSeq, PubMed]; Transcription regulator which is essential for male fertility and for the completion of meiotic prophase in spermatocytes (PubMed:18849567, PubMed:33961623, PubMed:34075040, PubMed:35320728, PubMed:35341968). Regulates progression of the pachytene stage of meiotic prophase by activating the expression of genes involved in meiosis and post-meiosis during spermatogenesis (PubMed:35341968). Maintains the repression of pre-pachytene transcriptional programs, including meiotic double-strand breaks (DSB) formation genes in pachytene spermatocytes and suppresses aberrant DSB formation after mid-pachytene, thus ensuring meiosis progression (PubMed:35320728)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; ZFP541 and KCTD19 regulate chromatin organization and transcription programs for male meiotic progression., [RefSeq, PubMed]; ZFP541 maintains the repression of pre-pachytene transcriptional programs and promotes male meiosis progression., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RXS6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q0GGX2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q56A10-1", "uniprot_id": [ { "id": "ZN608_MOUSE", "url": "https://www.uniprot.org/uniprot/Q56A10", "type": "external" } ], "mass": 162345.0, "length": 1511, "protein_name": "Zinc finger protein 608", "gene_name": "Zfp608; Znf608", "organism": "Mouse", "refseq_name": "zinc finger protein 608 isoform 1", "refseq_ac": [ { "id": "NP_786927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786927", "type": "external" } ], "gene_names_uniprotkb": "Zfp608; Znf608; Kiaa1281; Zfp608", "gene_names_refseq": "4932417D18Rik; D430007A19Rik; Zfp608; Znf608", "protein_names_uniprotkb": "Zinc finger protein 608", "protein_names_refseq": "zinc finger protein 608 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:269023)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21750661;22645316;23076336;34428180", "class_list": "", "function": "Transcription factor, which represses ZNF609 transcription., [UniProtKB, PubMed]; Zfp608 represses Rag1 and Rag2 expression indirectly by repressing the expression of Zfp609 in tymocytes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPU8;Q8BIG5;Q8BJ06", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0033085 negative regulation of T cell differentiation in thymus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q56A10-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62522-1", "uniprot_id": [ { "id": "ZPBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62522", "type": "external" } ], "mass": 39232.0, "length": 350, "protein_name": "Zona pellucida-binding protein 1", "gene_name": "Zpbp", "organism": "Mouse", "refseq_name": "zona pellucida-binding protein 1 isoform 1", "refseq_ac": [ { "id": "NP_056600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056600", "type": "external" } ], "gene_names_uniprotkb": "Zpbp; Zpbp1", "gene_names_refseq": "4930486K01Rik; Iam38; Sp38; Zpbp", "protein_names_uniprotkb": "Zona pellucida-binding protein 1; Inner acrosomal membrane IAM38; Sp38", "protein_names_refseq": "inner acrosomal membrane IAM38; zona pellucida-binding protein 1 isoform 1; zona pellucida-binding protein 1", "tax_id": 10090, "disease": "spermatogenic failure 66 (Disease Ontology:DOID:0070565)", "pathway": " (mmu:53604)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17664285;19204925;21750661;34231842", "class_list": "", "function": "Data show that loss of zona pellucida binding proteins 1 and 2 in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. Erratum:[Mol Cell Biol. 2008 Apr;28(7):2495], [RefSeq, PubMed]; Plays a role in acrosome compaction and sperm morphogenesis. Is implicated in sperm-oocyte interaction during fertilization., [UniProtKB, PubMed]; The localization of IAM38 on the extracellular side of both the inner and outer acrosomal membrane during the cap phase of acrosomal development supports the role of this prominent protein in acrosomal compaction., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9CR97", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0001669 acrosomal vesicle;GO:0044297 cell body;GO:0002080 acrosomal membrane;GO:0002199 zona pellucida receptor complex", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0001675 acrosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62522-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SSH7-1", "uniprot_id": [ { "id": "ZZEF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SSH7", "type": "external" } ], "mass": 328312.0, "length": 2924, "protein_name": "Zinc finger ZZ-type and EF-hand domain-containing protein 1", "gene_name": "Zzef1", "organism": "Mouse", "refseq_name": "zinc finger ZZ-type and EF-hand domain-containing protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001039001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039001", "type": "external" } ], "gene_names_uniprotkb": "Zzef1; Kiaa0399", "gene_names_refseq": "8430405D05Rik; C130099L13Rik; NSPA; Zzef1; mKIAA0399", "protein_names_uniprotkb": "Zinc finger ZZ-type and EF-hand domain-containing protein 1", "protein_names_refseq": "KIAA0399-like protein human; neuronal superface P antigen; zinc finger ZZ-type and EF-hand domain-containing protein 1 isoform 2; zinc finger ZZ-type and EF-hand domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:195018)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "17242355;19131326;20485683;21183079;21750661;22872234;25428506;25709106;27802388;30084848;30779550;31219806;34203471;34428180;36210013", "class_list": "", "function": "Histone H3 reader which may act as a transcriptional coactivator for KLF6 and KLF9 transcription factors., [UniProtKB, UniProtKB]; Zzef1 encodes for a protein that was named Neuronal Superface P Antigen (NSPA). NSPA is highly expressed in the hippocampus. The phenotype of Zzef1 knock-in mice includes decreased NMDAR activity and LTP by electrophysiology and impaired memory., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q499C8;Q6ZQC5;Q8C710;Q8CI54", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0042393 histone binding;GO:0061659 ubiquitin-like protein ligase activity", "go_cellular_component": "GO:0009986 cell surface;GO:0045202 synapse;GO:0048786 presynaptic active zone;GO:0098794 postsynapse", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0008542 visual learning;GO:0035249 synaptic transmission, glutamatergic;GO:0048167 regulation of synaptic plasticity;GO:0050730 regulation of peptidyl-tyrosine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q5SSH7-1", "record_type": "protein", "filter_code": "0000000.1000101.001000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSH3-1", "uniprot_id": [ { "id": "ZN516_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TSH3", "type": "external" } ], "mass": 124788.0, "length": 1157, "protein_name": "Zinc finger protein 516", "gene_name": "Zfp516; Znf516", "organism": "Mouse", "refseq_name": "zinc finger protein 516", "refseq_ac": [ { "id": "NP_001170935", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170935", "type": "external" } ], "gene_names_uniprotkb": "Zfp516; Znf516; Kiaa0222; Zfp516", "gene_names_refseq": "C330029B10Rik; D230016L03; Zfp26l; Zfp516; Znf516; mKIAA0222", "protein_names_uniprotkb": "Zinc finger protein 516", "protein_names_refseq": "zinc finger protein 516", "tax_id": 10090, "disease": "", "pathway": " (mmu:329003)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;21913724;25578880;27264172;28528544;29846698;31219806;34180153", "class_list": "", "function": "Through interaction with Zfp516, LSD1 is recruited to UCP1 and other brown adipose tissue-enriched genes., [RefSeq, PubMed]; Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis. May also play a role in the cellular response to replication stress (By similarity)., [UniProtKB, PubMed, UniProtKB]; Zfp217 and Zfp516 facilitate Ctbp2-mediated repression on active embryonic stem cell genes during differentiation., [RefSeq, PubMed]; Zfp516 directly binds to the proximal region of the UCP1 promoter, not to the enhancer region where other transcription factors bind, and interacts with PRDM16 to activate the UCP1 promoter., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0009409 response to cold;GO:0050873 brown fat cell differentiation;GO:0060612 adipose tissue development;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q7TSH3-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0A2-1", "uniprot_id": [ { "id": "ZBT44_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0A2", "type": "external" } ], "mass": 50175.0, "length": 453, "protein_name": "Zinc finger and BTB domain-containing protein 44", "gene_name": "Zbtb44", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 44 isoform a", "refseq_ac": [ { "id": "NP_001108602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108602", "type": "external" } ], "gene_names_uniprotkb": "Zbtb44; Btbd15", "gene_names_refseq": "6030404E16Rik; Btbd15; E230011F09; Zbtb44", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 44; BTB/POZ domain-containing protein 15", "protein_names_refseq": "BTB (POZ) domain containing 15; BTB/POZ domain-containing protein 15; zinc finger and BTB domain-containing protein 44 isoform a; zinc finger and BTB domain-containing protein 44", "tax_id": 10090, "disease": "", "pathway": " (mmu:235132)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17242355;21183079;21750661;40997131", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CB31", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R0A2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q52KG4-1", "uniprot_id": [ { "id": "ZBT45_MOUSE", "url": "https://www.uniprot.org/uniprot/Q52KG4", "type": "external" } ], "mass": 55012.0, "length": 520, "protein_name": "Zinc finger and BTB domain-containing protein 45", "gene_name": "Zbtb45", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 45", "refseq_ac": [ { "id": "NP_001019870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019870", "type": "external" } ], "gene_names_uniprotkb": "Zbtb45; Gm157; Zfp499", "gene_names_refseq": "Gm157; Zbtb45; Zfp499", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 45; Zinc finger protein 499", "protein_names_refseq": "zinc finger and BTB domain-containing protein 45; zinc finger protein 499", "tax_id": 10090, "disease": "", "pathway": " (mmu:232879)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21131782;21750661;40997131", "class_list": "", "function": "Data suggest that Zbtb45 is a novel regulator of glial differentiation., [RefSeq, PubMed]; May be involved in transcriptional regulation (Probable). In the central nervous system, may play a role in glial cell differentiation (PubMed:21131782)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLP9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0002682 regulation of immune system process;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q52KG4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YT7-1", "uniprot_id": [ { "id": "YTHD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YT7", "type": "external" } ], "mass": 62280.0, "length": 579, "protein_name": "YTH domain-containing family protein 2", "gene_name": "Ythdf2", "organism": "Mouse", "refseq_name": "YTH domain-containing family protein 2", "refseq_ac": [ { "id": "NP_663368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663368", "type": "external" } ], "gene_names_uniprotkb": "Ythdf2", "gene_names_refseq": "9430020E02Rik; HGRG8; NY-REN-2; Ythdf2", "protein_names_uniprotkb": "YTH domain-containing family protein 2", "protein_names_refseq": "YTH domain family 2; YTH domain-containing family protein 2", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667)", "pathway": " (mmu:213541)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "21750661;25428506;28867294;29855337;30065315;30107516;30150673;30559377;31959747;32782141;32905781;32943573;34428180;34887587;36765030;36852467;37828378;39425013;40021952;40885482", "class_list": "", "function": "Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability (PubMed:28867294, PubMed:29855337, PubMed:32943573). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:28867294, PubMed:29855337, PubMed:32943573). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT and ribonuclease P/MRP complexes, depending on the context (PubMed:29855337, PubMed:30065315, PubMed:32905781, PubMed:32943573). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:32943573). M6A-containing mRNAs containing a binding site for RIDA/HRSP12 (5'-GGUUC-3') are preferentially degraded by endoribonucleolytic cleavage: cooperative binding of RIDA/HRSP12 and YTHDF2 to transcripts leads to recruitment of the ribonuclease P/MRP complex (By similarity). Other m6A-containing mRNAs undergo deadenylation via direct interaction between YTHDF2 and CNOT1, leading to recruitment of the CCR4-NOT and subsequent deadenylation of m6A-containing mRNAs (PubMed:32905781). Required maternally to regulate oocyte maturation: probably acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence of oocytes to sustain early zygotic development (PubMed:28867294). Also required during spermatogenesis: regulates spermagonial adhesion by promoting degradation of m6A-containing transcripts coding for matrix metallopeptidases (PubMed:31959747). Also involved in hematopoietic stem cells specification by binding to m6A-containing mRNAs, leading to promote their degradation (PubMed:30065315, PubMed:30150673). Also acts as a regulator of neural development by promoting m6A-dependent degradation of neural development-related mRNA targets (PubMed:29855337). Inhibits neural specification of induced pluripotent stem cells by binding to methylated neural-specific mRNAs and promoting their degradation, thereby restraining neural differentiation (By similarity). Regulates circadian regulation of hepatic lipid metabolism: acts by promoting m6A-dependent degradation of PPARA transcripts (By similarity). Regulates the innate immune response to infection by inhibiting the type I interferon response: acts by binding to m6A-containing IFNB transcripts and promoting their degradation (PubMed:30559377). May also act as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation (By similarity). Regulates mitotic entry by promoting the phase-specific m6A-dependent degradation of WEE1 transcripts (By similarity). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (By similarity). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (By similarity). May also recognize and bind RNAs modified by C5-methylcytosine (m5C) and act as a regulator of rRNA processing (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The m(6)A-reader YTHDF2 is an intrinsic determinant of mammalian oocyte competence and early zygotic development., [RefSeq, PubMed]; The study provides the first demonstration of the function of YTHDF2 in adult stem cell maintenance and identifies its important role in regulating HSC ex vivo expansion by regulating the stability of multiple mRNAs critical for HSC self-renewal, thus identifying potential for future clinical applications. Erratum:[Cell Res. 2018 Oct;28(10):1042. doi: 10.1038/s41422-018-0083-x. PMID: 30150672], [RefSeq, PubMed]; These data together suggest that FMRP regulates the stability of its m6A-marked mRNA targets through YTHDF2, which could potentially contribute to the molecular pathogenesis of Fragile X syndrome., [RefSeq, PubMed]; Ythdf2 modulates neural development by promoting m(6)A-dependent degradation of neural development-related mRNA targets. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3TWU3;Q8BM70;Q8K325", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:1990247 N6-methyladenosine-containing RNA reader activity;GO:0062153 C5-methylcytidine-containing RNA reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:1903679 positive regulation of cap-independent translational initiation;GO:2000232 regulation of rRNA processing;GO:0030155 regulation of cell adhesion;GO:0045087 innate immune response;GO:0043488 regulation of mRNA stability", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q91YT7-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PYI1-1", "uniprot_id": [ { "id": "ZN568_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PYI1", "type": "external" } ], "mass": 77116.0, "length": 671, "protein_name": "Zinc finger protein 568", "gene_name": "Zfp568; Znf568", "organism": "Mouse", "refseq_name": "zinc finger protein 568 isoform 1", "refseq_ac": [ { "id": "NP_001028527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028527", "type": "external" } ], "gene_names_uniprotkb": "Zfp568; Znf568; Zfp568; chato", "gene_names_refseq": "Gm1691; Zfp568; Znf568; chato", "protein_names_uniprotkb": "Zinc finger protein 568", "protein_names_refseq": "zinc finger protein 568 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:243905)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "18701545;21094155;21750661;22110054;23071813;27658112;28522536", "class_list": "", "function": "A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568, [RefSeq, PubMed]; Chato regulates convergent extension in the mouse embryo., [RefSeq, PubMed]; Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but also has repression activity independently of this interaction (PubMed:22110054, PubMed:27658112). Essential during embryonic development, where it acts as direct repressor of IGF2-P0, placental-specific transcript of IGF2, in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers (PubMed:18701545, PubMed:22110054, PubMed:28522536). Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta (PubMed:18701545, PubMed:21094155). May enhance proliferation or maintenance of neural stem cells (PubMed:23071813)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The results revealed that TRIM28 is differentially required by ZFP568 and other factors during the early stages of mouse embryogenesis., [RefSeq, PubMed]; ZFP568 controls the production of secreted factors required to promote morphogenesis of extraembryonic tissues., [RefSeq, PubMed]; Zfp568 is both a neural stem cell-maintaining and a brain size-regulating gene., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VGV0;Q3UPK4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "E9PYI1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0P7-1", "uniprot_id": [ { "id": "ZN451_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0P7", "type": "external" } ], "mass": 120070.0, "length": 1056, "protein_name": "E3 SUMO-protein ligase ZNF451", "gene_name": "Zfp451; Znf451", "organism": "Mouse", "refseq_name": "E3 SUMO-protein ligase ZNF451 isoform 2", "refseq_ac": [ { "id": "NP_001277628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277628", "type": "external" } ], "gene_names_uniprotkb": "Zfp451; Znf451; Zfp451", "gene_names_refseq": "4930515K21Rik; 4933435G09Rik; COASTER; Kiaa0576-hp; Zfp451; Znf451; mKIAA1702", "protein_names_uniprotkb": "E3 SUMO-protein ligase ZNF451; 2.3.2.-; E3 SUMO-protein transferase ZNF451; Zinc finger protein 451", "protein_names_refseq": "E3 SUMO-protein ligase ZNF451 isoform 2; E3 SUMO-protein ligase ZNF451; E3 SUMO-protein transferase ZNF451", "tax_id": 10090, "disease": "", "pathway": " (mmu:98403)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;26524493;27343429;34428180;38600524", "class_list": "", "function": "A regulatory role of ZNF451-1 in fine-tuning physiological PML levels, [RefSeq, PubMed]; E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins. Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation. Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11'. Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9'. Plays a role in regulating the transcription of AR targets (By similarity)., [UniProtKB, PubMed, UniProtKB]; Loss of ZNF451 mediates fibroblast activation and promotes lung fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016605 PML body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0016925 protein sumoylation;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0060633 negative regulation of transcription initiation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8C0P7-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VGT4-1", "uniprot_id": [ { "id": "ZGRF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0VGT4", "type": "external" } ], "mass": 205737.0, "length": 1863, "protein_name": "5'-3' DNA helicase ZGRF1", "gene_name": "Zgrf1", "organism": "Mouse", "refseq_name": "5'-3' DNA helicase ZGRF1", "refseq_ac": [ { "id": "NP_932114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932114", "type": "external" } ], "gene_names_uniprotkb": "Zgrf1", "gene_names_refseq": "4930422G04Rik; Zgrf1", "protein_names_uniprotkb": "5'-3' DNA helicase ZGRF1; 5.6.2.3; GRF-type zinc finger domain-containing protein 1", "protein_names_refseq": "5'-3' DNA helicase ZGRF1; GRF-type zinc finger domain-containing protein 1; protein ZGRF1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71643)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "5'-3' DNA helicase which is recruited to sites of DNA damage and promotes repair of replication-blocking DNA lesions through stimulation of homologous recombination (HR). Promotes HR by directly stimulating RAD51-mediated strand exchange activity. Not required to load RAD51 at sites of DNA damage but promotes recombinational repair after RAD51 recruitment. Also promotes HR by positively regulating EXO1-mediated DNA end resection of DNA double-strand breaks. Required for recruitment of replication protein RPA2 to DNA damage sites. Promotes the initiation of the G2/M checkpoint but not its maintenance. Catalyzes Holliday junction branch migration and dissociation of D-loops and DNA flaps., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9Q2K6", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0043139 5'-3' DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body", "go_biological_process": "GO:0000725 recombinational repair;GO:0006369 termination of RNA polymerase II transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0VGT4-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NXK2-1", "uniprot_id": [ { "id": "ZN532_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NXK2", "type": "external" } ], "mass": 110949.0, "length": 1036, "protein_name": "Zinc finger protein 532", "gene_name": "Zfp532; Znf532", "organism": "Mouse", "refseq_name": "zinc finger protein 532 isoform 2", "refseq_ac": [ { "id": "NP_997138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997138", "type": "external" } ], "gene_names_uniprotkb": "Zfp532; Znf532; Kiaa1629; Zfp532", "gene_names_refseq": "C530030I18Rik; Zfp532; Znf532; mKIAA1629", "protein_names_uniprotkb": "Zinc finger protein 532", "protein_names_refseq": "zinc finger protein 532 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:328977); (R-MMU-9940951)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "21183079;21750661;22517741;22645316;23806337;25428506;34839589;36852467;40885482", "class_list": "", "function": "CircZNF532 knockdown protects retinal pigment epithelial cells against high glucose-induced apoptosis and pyroptosis by regulating the miR-20b-5p/STAT3 axis., [RefSeq, PubMed]; May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q504Z6;Q6ZPL1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q6NXK2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PD29-1", "uniprot_id": [ { "id": "ZN513_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PD29", "type": "external" } ], "mass": 58067.0, "length": 541, "protein_name": "Zinc finger protein 513", "gene_name": "Zfp513; Znf513", "organism": "Mouse", "refseq_name": "zinc finger protein 513 isoform 2", "refseq_ac": [ { "id": "NP_001171372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171372", "type": "external" } ], "gene_names_uniprotkb": "Zfp513; Znf513; Zfp513", "gene_names_refseq": "D430028M17Rik; Zfp513; Znf513", "protein_names_uniprotkb": "Zinc finger protein 513", "protein_names_refseq": "zinc finger protein 513 isoform 2", "tax_id": 10090, "disease": "retinitis pigmentosa 58 (Disease Ontology:DOID:0110362)", "pathway": " (mmu:101023)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20797688;21183079;21750661", "class_list": "", "function": "These results suggest that the ZNF513 p.C339R mutation is responsible for retinitis pigmentosa and that ZNF513 plays a key role in the regulation of photoreceptor-specific genes in retinal development and photoreceptor maintenance., [RefSeq, PubMed]; Transcriptional regulator that plays a role in retinal development and maintenance., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4K1;Q8BWH6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0060041 retina development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PD29-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VL9-1", "uniprot_id": [ { "id": "ZBTB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VL9", "type": "external" } ], "mass": 81952.0, "length": 713, "protein_name": "Zinc finger and BTB domain-containing protein 1", "gene_name": "Zbtb1", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_848859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848859", "type": "external" } ], "gene_names_uniprotkb": "Zbtb1", "gene_names_refseq": "9430077A12; Bsg2; C430003J21Rik; Zbtb1", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 1", "protein_names_refseq": "brain specific protein 2; zinc finger and BTB domain-containing protein 1 isoform 1; zinc finger and BTB domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:268564)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;22201126;22753936;27402700;27542215;34290994", "class_list": "", "function": "Acts as a transcriptional repressor (By similarity). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (By similarity). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (By similarity). Plays a key role in the transcriptional regulation of T lymphocyte development (PubMed:22201126, PubMed:22753936)., [UniProtKB, PubMed, PubMed, UniProtKB]; MicroRNA and circRNA Expression Analysis in a Zbtb1 Gene Knockout Monoclonal EL4 Cell Line. Publication Status: Online-Only, [RefSeq, PubMed]; These results indicate that Zbtb1 prevents DNA damage in replicating immune progenitors, allowing the generation of B cells, T cells, and myeloid cells., [RefSeq, PubMed]; These results show that Zbtb1 expression prevents activation of a default myeloid program in LMPP cells, ensuring the generation of lymphoid cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CDP7;Q99LD2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0016604 nuclear body", "go_biological_process": "GO:0002711 positive regulation of T cell mediated immunity;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q91VL9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2D7-1", "uniprot_id": [ { "id": "ZN687_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2D7", "type": "external" } ], "mass": 130350.0, "length": 1237, "protein_name": "Zinc finger protein 687", "gene_name": "Zfp687; Znf687", "organism": "Mouse", "refseq_name": "zinc finger protein 687", "refseq_ac": [ { "id": "NP_084350", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084350", "type": "external" } ], "gene_names_uniprotkb": "Zfp687; Znf687; Kiaa1441; Zfp687", "gene_names_refseq": "4931408L03Rik; Zfp687; Znf687; mKIAA1441", "protein_names_uniprotkb": "Zinc finger protein 687", "protein_names_refseq": "zinc finger protein 687", "tax_id": 10090, "disease": "Paget's disease of bone 6 (Disease Ontology:DOID:0081369)", "pathway": " (mmu:78266); (R-MMU-9940951)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17242355;21183079;21750661;24129315", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PAP3;Q6ZPQ9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D2D7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2U2-1", "uniprot_id": [ { "id": "ZN292_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2U2", "type": "external" } ], "mass": 301048.0, "length": 2698, "protein_name": "Zinc finger protein 292", "gene_name": "Zfp292", "organism": "Mouse", "refseq_name": "zinc finger protein 292 isoform 1", "refseq_ac": [ { "id": "NP_038917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038917", "type": "external" } ], "gene_names_uniprotkb": "Zfp292; Zfp15", "gene_names_refseq": "5730450D02Rik; 5830493J20Rik; 9430062L07Rik; Krox-10; Zfp-15; Zfp15; Zfp292; Zn-15; Zn-16; mKIAA0530", "protein_names_uniprotkb": "Zinc finger protein 292; Zfp-15; Zinc finger protein 15", "protein_names_refseq": "zinc finger protein 15; zinc finger protein 292 isoform 1", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 64 (Disease Ontology:DOID:0061037)", "pathway": " (mmu:30046)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10687855;12166626;21183079;23806337;28319097;34203471;34428180;36852467", "class_list": "", "function": "First in vivo evidence that Zn-16 mRNA abundance correlates with growth hormone expression, [RefSeq, PubMed]; May be involved in transcriptional regulation., [UniProtKB]; This study shows that long noncoding RNA Kdm2b expression sustains the maintenance of Innate lymphoid cells by promoting their proliferation through activation of the transcription factor Zfp292, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B1B0E1;B1B0E2;Q8BQX3;Q8BS87;Q8CGI6;Q922D3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Z2U2-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0G7-1", "uniprot_id": [ { "id": "ZEB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0G7", "type": "external" } ], "mass": 136615.0, "length": 1215, "protein_name": "Zinc finger E-box-binding homeobox 2", "gene_name": "Zeb2", "organism": "Mouse", "refseq_name": "zinc finger E-box-binding homeobox 2", "refseq_ac": [ { "id": "NP_001276450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276450", "type": "external" } ], "gene_names_uniprotkb": "Zeb2; Sip1; Zfhx1b; Zfx1b", "gene_names_refseq": "9130203F04Rik; D130016B08Rik; SIP1; Zeb2; Zfhx1b; Zfx1b; Zfxh1b", "protein_names_uniprotkb": "Zinc finger E-box-binding homeobox 2; Smad-interacting protein 1; Zinc finger homeobox protein 1b", "protein_names_refseq": "smad-interacting protein 1; zinc finger E-box-binding homeobox 2; zinc finger homeobox protein 1b", "tax_id": 10090, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); Mowat-Wilson syndrome (Disease Ontology:DOID:0060485); Hirschsprung's disease (Disease Ontology:DOID:10487); T-cell adult acute lymphocytic leukemia (Disease Ontology:DOID:5602); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:24136); (R-MMU-9762293)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10400677;21183079;21750661;22645316;25428506;30059200;30084848;30779550;34428180;35820727;36210013;39627609", "class_list": "", "function": "Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin. Represses expression of MEOX2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6P9M5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005886 plasma membrane;GO:0000785 chromatin", "go_biological_process": "GO:0010764 negative regulation of fibroblast migration;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9R0G7-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35601-1", "uniprot_id": [ { "id": "RFC1_MOUSE", "url": "https://www.uniprot.org/uniprot/P35601", "type": "external" } ], "mass": 125985.0, "length": 1131, "protein_name": "Replication factor C subunit 1", "gene_name": "Rfc1", "organism": "Mouse", "refseq_name": "replication factor C subunit 1 isoform 2", "refseq_ac": [ { "id": "NP_035388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035388", "type": "external" } ], "gene_names_uniprotkb": "Rfc1; Ibf-1; Recc1", "gene_names_refseq": "140kDa; Alp145; RFC140; Recc1; Rfc1", "protein_names_uniprotkb": "Replication factor C subunit 1; A1 140 kDa subunit; A1-P145; Activator 1 140 kDa subunit; Activator 1 large subunit; Activator 1 subunit 1; Differentiation-specific element-binding protein; ISRE-binding protein; RF-C 140 kDa subunit; RFC140; Replication factor C 140 kDa subunit; Replication factor C large subunit", "protein_names_refseq": "A1 140 kDa subunit; A1-P145; ISRE-binding protein; RF-C 140 kDa subunit; activator 1 140 kDa subunit; activator 1 large subunit; activator 1 subunit 1; differentiation-specific element-binding protein; replication factor C 140 kDa subunit; replication factor C 1; replication factor C large subunit; replication factor C subunit 1 isoform 2; replication factor C subunit 1; replication factor C, 140 kDa", "tax_id": 10090, "disease": "cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (Disease Ontology:DOID:0070148); congenital heart disease (Disease Ontology:DOID:1682); West Nile fever (Disease Ontology:DOID:2366)", "pathway": " (mmu:19687); (R-MMU-110312); (R-MMU-110314); (R-MMU-110320); (R-MMU-174411); (R-MMU-5651801); (R-MMU-5655862); (R-MMU-5656121); (R-MMU-5656169); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5696397); (R-MMU-5696400); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-69091)", "pathway_count": 16, "publication_count": 14, "publication_id_list": "1691767;17242355;19144319;21183079;21750661;25428506;25605945;30084848;34428180;34887587;39627609;7659092;8114700;8265586", "class_list": "", "function": "Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0016887 ATP hydrolysis activity;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032991 protein-containing complex;GO:0031391 Elg1 RFC-like complex;GO:0005663 DNA replication factor C complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P35601-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YK2-1", "uniprot_id": [ { "id": "RRP1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YK2", "type": "external" } ], "mass": 80582.0, "length": 724, "protein_name": "Ribosomal RNA processing protein 1 homolog B", "gene_name": "Rrp1b", "organism": "Mouse", "refseq_name": "ribosomal RNA processing protein 1 homolog B isoform 1", "refseq_ac": [ { "id": "NP_082520", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082520", "type": "external" } ], "gene_names_uniprotkb": "Rrp1b", "gene_names_refseq": "2600005C20Rik; D030064A17; Kiaa0179; Rrp1b; mKIAA0179", "protein_names_uniprotkb": "Ribosomal RNA processing protein 1 homolog B; RRP1-like protein B", "protein_names_refseq": "RRP1-like protein B; ribosomal RNA processing 1 homolog B; ribosomal RNA processing protein 1 homolog B isoform 1; ribosomal RNA processing protein 1 homolog B", "tax_id": 10090, "disease": "", "pathway": " (mmu:72462)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "18081427;19710015;21750661;23604122;24463520;25428506;30084848;30779550;34428180;35820727", "class_list": "", "function": "Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (By similarity). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (By similarity). Involved in regulation of mRNA splicing (PubMed:23604122). Inhibits SIPA1 GTPase activity (PubMed:18081427). Involved in regulating expression of extracellular matrix genes (PubMed:18081427). Associates with chromatin and may play a role in modulating chromatin structure (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; RRP1B suppresses metastatic progression by altering the transcriptome through its interaction with splicing regulators such as SRSF1, [RefSeq, PubMed]; RRP1B, a tumor progression and metastasis susceptibility candidate gene, is potentially a dynamic modulator of transcription and chromatin structure, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0V2W7", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005694 chromosome;GO:0000791 euchromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006397 mRNA processing;GO:0043065 positive regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q91YK2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERD6-1", "uniprot_id": [ { "id": "RGPS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERD6", "type": "external" } ], "mass": 65530.0, "length": 590, "protein_name": "Ras-specific guanine nucleotide-releasing factor RalGPS2", "gene_name": "Ralgps2", "organism": "Mouse", "refseq_name": "ras-specific guanine nucleotide-releasing factor RalGPS2 isoform a", "refseq_ac": [ { "id": "NP_001153437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153437", "type": "external" } ], "gene_names_uniprotkb": "Ralgps2", "gene_names_refseq": "1810020P17Rik; 2210408F11Rik; 4921528G01Rik; 9130014M22Rik; Ralgps2", "protein_names_uniprotkb": "Ras-specific guanine nucleotide-releasing factor RalGPS2; Ral GEF with PH domain and SH3-binding motif 2; RalA exchange factor RalGPS2", "protein_names_refseq": "ral GEF with PH domain and SH3-binding motif 2; ralA exchange factor RalGPS2; ras-specific guanine nucleotide-releasing factor RalGPS2 isoform a; ras-specific guanine nucleotide-releasing factor RalGPS2", "tax_id": 10090, "disease": "", "pathway": " (mmu:78255)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10747847;12485849;16479539;17242355;17462626;21183079;21750661;31219806;34203471;34428180;36210013", "class_list": "", "function": "Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion., [UniProtKB, PubMed]; RalGPS2 was characterized., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPZ6;Q80YA6;Q8BZ37;Q8BZU2;Q9D2Y7", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0032485 regulation of Ral protein signal transduction;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9ERD6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q76KF0-1", "uniprot_id": [ { "id": "SEM6D_MOUSE", "url": "https://www.uniprot.org/uniprot/Q76KF0", "type": "external" } ], "mass": 119815.0, "length": 1073, "protein_name": "Semaphorin-6D", "gene_name": "Sema6d", "organism": "Mouse", "refseq_name": "semaphorin-6D isoform Sema6D-2 precursor", "refseq_ac": [ { "id": "NP_001277926", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277926", "type": "external" } ], "gene_names_uniprotkb": "Sema6d; Kiaa1479", "gene_names_refseq": "1110067B02Rik; D330011G23; Sema6d; mKIAA1479", "protein_names_uniprotkb": "Semaphorin-6D", "protein_names_refseq": "semaphorin-6D isoform Sema6D-2 precursor; semaphorin-6D", "tax_id": 10090, "disease": "", "pathway": " (mmu:214968); (R-MMU-416700)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;14715272;14977921;15543137;16715077;21183079;21750661;22645316;26495903;28011936;32848054;37344233;38329122;39002542;40885482", "class_list": "", "function": "Plexin-S1, with Sema6D, exerts distinct biological activities at adjacent regions, crucial for complex cardiac morphogenesis., [RefSeq, PubMed]; Sema6D coordinates both compact-layer expansion and trabeculation, functioning as both a ligand and a receptor for Plexin-A1., [RefSeq, PubMed]; Sema6D forward signaling impairs T cell activation and proliferation in head and neck cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs., [RefSeq, PubMed]; Semaphorin-6D and Plexin-A1 Act in a Non-Cell-Autonomous Manner to Position and Target Retinal Ganglion Cell Axons., [RefSeq, PubMed]; Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections (By similarity). Ligand of TREM2 with PLXNA1 as coreceptor in dendritic cells, plays a role in the generation of immune responses and skeletal homeostasis (PubMed:16715077)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A2AW72;Q76KF1;Q76KF2;Q76KF3;Q76KF4;Q80TD0", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0045499 chemorepellent activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0014912 negative regulation of smooth muscle cell migration", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q76KF0-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35280-1", "uniprot_id": [ { "id": "CHK1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35280", "type": "external" } ], "mass": 54381.0, "length": 476, "protein_name": "Serine/threonine-protein kinase Chk1", "gene_name": "Chek1", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase Chk1 isoform 1", "refseq_ac": [ { "id": "NP_031717", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031717", "type": "external" } ], "gene_names_uniprotkb": "Chek1; Chk1", "gene_names_refseq": "Chek1; Chk1; rad27", "protein_names_uniprotkb": "Serine/threonine-protein kinase Chk1; 2.7.11.1; CHK1 checkpoint homolog; Checkpoint kinase-1", "protein_names_refseq": "CHK1 checkpoint homolog; checkpoint kinase 1 homolog; rad27 homolog; serine/threonine-protein kinase Chk1 isoform 1; serine/threonine-protein kinase Chk1", "tax_id": 10090, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (mmu:12649); (R-MMU-1433557); (R-MMU-176187); (R-MMU-5693607); (R-MMU-5693616); (R-MMU-6804756); (R-MMU-69473); (R-MMU-69601); (R-MMU-8953750)", "pathway_count": 9, "publication_count": 44, "publication_id_list": "10859163;10859164;15261141;15710331;17376776;18243098;18299400;18381462;18812521;19406993;21183079;21304913;21750661;21921034;21952136;22448250;22872234;23418588;23785666;23950734;24184701;24553354;25428506;25428911;25605945;25690891;27556692;28099140;28572758;30084848;30779550;30975914;31219806;32071282;32571801;33087841;34428180;35768646;35820727;36210013;38917519;39927985;9278511;9382850", "class_list": "", "function": "Critical role of checkpoint kinase 1 in spinal cord injury-induced motor dysfunction in mice., [RefSeq, PubMed]; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:10859163, PubMed:10859164, PubMed:15261141). May also negatively regulate cell cycle progression during unperturbed cell cycles (PubMed:10859163, PubMed:10859164, PubMed:15261141). This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome (PubMed:10859163, PubMed:10859164, PubMed:15261141). Recognizes the substrate consensus sequence [R-X-X-S/T] (PubMed:10859163, PubMed:10859164, PubMed:15261141). Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A. Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A. Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Also phosphorylates NEK6. Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination. Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation. Also promotes repair of DNA cross-links through phosphorylation of FANCE. Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may enhance chromatin assembly both in the presence or absence of DNA damage. May also play a role in replication fork maintenance through regulation of PCNA (By similarity). May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones. Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes (PubMed:18243098). May also phosphorylate RB1 to promote its interaction with the E2F family of transcription factors and subsequent cell cycle arrest. Phosphorylates SPRTN, promoting SPRTN recruitment to chromatin (By similarity). Reduces replication stress and activates the G2/M checkpoint, by phosphorylating and inactivating PABIR1/FAM122A and promoting the serine/threonine-protein phosphatase 2A-mediated dephosphorylation and stabilization of WEE1 levels and activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O54925;Q8CI40;Q9D0N2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0035402 histone H3T11 kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0046602 regulation of mitotic centrosome separation;GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006468 protein phosphorylation;GO:0007077 mitotic nuclear membrane disassembly", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "O35280-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CYP7-1", "uniprot_id": [ { "id": "SESN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CYP7", "type": "external" } ], "mass": 57021.0, "length": 492, "protein_name": "Sestrin-3", "gene_name": "Sesn3", "organism": "Mouse", "refseq_name": "sestrin-3", "refseq_ac": [ { "id": "NP_084537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084537", "type": "external" } ], "gene_names_uniprotkb": "Sesn3", "gene_names_refseq": "5630400E15Rik; SEST3; Sesn3", "protein_names_uniprotkb": "Sestrin-3; 1.11.1.-", "protein_names_refseq": "sestrin-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:75747); (R-MMU-5628897)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "20412774;21750661;22958918;25259925;25377878;34428180;34946801;36210013;36220588;38297375", "class_list": "", "function": "Aerobic exercise ameliorates insulin resistance in C57BL/6 J mice via activating Sestrin3., [RefSeq, PubMed]; Concomitant ablation of Sesn2 and Sesn3 provokes hepatic mTORC1-S6K activation and insulin resistance even in the absence of nutritional overload and obesity., [RefSeq, PubMed]; FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor, [RefSeq, PubMed]; May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25259925). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (PubMed:25377878). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; SESN3 Inhibited SMAD3 to Relieve Its Suppression for MiR-124, Thus Regulating Pre-Adipocyte Adipogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Sestrin1, 2, and 3 are dispensable for female fertility in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2A0", "ec_number_list": [ { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0016684 oxidoreductase activity, acting on peroxide as acceptor;GO:0070728 L-leucine binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0061700 GATOR2 complex", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0042593 glucose homeostasis;GO:0032868 response to insulin;GO:0042149 cellular response to glucose starvation;GO:0016239 positive regulation of macroautophagy", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9CYP7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54804-1", "uniprot_id": [ { "id": "CHKA_MOUSE", "url": "https://www.uniprot.org/uniprot/O54804", "type": "external" } ], "mass": 51985.0, "length": 453, "protein_name": "Choline kinase alpha", "gene_name": "Chka", "organism": "Mouse", "refseq_name": "choline kinase alpha isoform 3", "refseq_ac": [ { "id": "NP_001258425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258425", "type": "external" } ], "gene_names_uniprotkb": "Chka; Chk", "gene_names_refseq": "CK/EK-alpha; CK; Chetk-alpha; Chka; Chk; ChoK; EK; EtnK-alpha", "protein_names_uniprotkb": "Choline kinase alpha; 2.7.1.32; 2.7.1.82; CHETK-alpha; CK; EK; Ethanolamine kinase", "protein_names_refseq": "choline kinase alpha isoform 3; choline/ethanolamine kinase alpha; ethanolamine kinase", "tax_id": 10090, "disease": "colon adenoma (Disease Ontology:DOID:0050912); microcephaly (Disease Ontology:DOID:10907); epilepsy (Disease Ontology:DOID:1826); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (mmu:12660); (R-MMU-1483191); (R-MMU-1483213)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10706593;11964179;16490392;18029352;21750661;26125130;34428180;9714798", "class_list": "", "function": "Experimental evidence for the presence of heteromeric ChoK/EtnK in any source. The activity of ChoK/EtnK in the cell is controlled not only by the level of each isoform but also by their combination to form the active oligomer complex., [RefSeq, PubMed]; Full-length cDNAs or their truncated or alanine-mutated versions for mouse CK-alpha1 and CK-beta were expressed in COS-7 cells., [RefSeq, PubMed]; Hepatic phosphatidylcholine is regulated by the circadian clock through a Bmal1-Rev-erbalpha-Chkalpha axis, [RefSeq, PubMed]; Plays a key role in phospholipid biosynthesis by catalyzing the phosphorylation of free choline to phosphocholine, the first step in phosphatidylcholine biosynthesis. Also phosphorylates ethanolamine, thereby contributing to phosphatidylethanolamine biosynthesis. Has higher activity with choline., [UniProtKB, UniProtKB]; This isoform plays a key role in lipolysis of lipid droplets following glucose deprivation (By similarity). In response to glucose deprivation, phosphorylated by AMPK, promoting localization to lipid droplets (By similarity). Phosphorylation is followed by acetylation by KAT5, leading to dissociation of the homodimer into a monomer (By similarity). Monomeric CHKA isoform 1 is converted into a tyrosine-protein kinase, which phosphorylates lipid droplet structural proteins PLIN2 and PLIN3, leading to lipolysis of lipid droplets (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G5E853;Q8BPL3;Q8BPW6;Q9CXP3;Q9QX56", "ec_number_list": [ { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0033265 choline binding;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0019695 choline metabolic process;GO:0006580 ethanolamine metabolic process;GO:0006657 CDP-choline pathway;GO:0006656 phosphatidylcholine biosynthetic process;GO:0042149 cellular response to glucose starvation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O54804-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A690-1", "uniprot_id": [ { "id": "TANC2_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A690", "type": "external" } ], "mass": 220263.0, "length": 1994, "protein_name": "Protein TANC2", "gene_name": "Tanc2", "organism": "Mouse", "refseq_name": "protein TANC2 isoform 2", "refseq_ac": [ { "id": "NP_851416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851416", "type": "external" } ], "gene_names_uniprotkb": "Tanc2; Kiaa1148", "gene_names_refseq": "3526402J09Rik; 5730590C14Rik; Tanc2", "protein_names_uniprotkb": "Protein TANC2; Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2", "protein_names_refseq": "Protein TANC2; protein TANC2 isoform 2; tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2", "tax_id": 10090, "disease": "intellectual developmental disorder with autistic features and language delay, with or without seizures (Disease Ontology:DOID:0081430)", "pathway": " (mmu:77097)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;16452087;20571061;21183079;21750661;22645316;24129315;32782141;32848054;33976205;34203471;34428180;34678516;34964047;35820727;35822049;38092135;40021952;40885482", "class_list": "", "function": "Post-synaptic scaffold protein TANC2 in psychiatric and somatic disease risk., [RefSeq, PubMed]; Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation., [RefSeq, PubMed]; Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons. Erratum:[Nat Commun. 2022 Nov 1;13(1):6544. doi: 10.1038/s41467-022-33972-9. PMID: 36319630] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "A2A683;Q3TRZ3;Q5EBP6;Q69ZQ7", "ec_number_list": [], "go_molecular_function": "GO:0098919 structural constituent of postsynaptic density", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0014069 postsynaptic density;GO:0030424 axon;GO:0043197 dendritic spine;GO:0099092 postsynaptic density, intracellular component", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0060998 regulation of dendritic spine development;GO:0061001 regulation of dendritic spine morphogenesis;GO:0099519 dense core granule cytoskeletal transport", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "A2A690-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35681-1", "uniprot_id": [ { "id": "SYT3_MOUSE", "url": "https://www.uniprot.org/uniprot/O35681", "type": "external" } ], "mass": 63254.0, "length": 587, "protein_name": "Synaptotagmin-3", "gene_name": "Syt3", "organism": "Mouse", "refseq_name": "synaptotagmin-3", "refseq_ac": [ { "id": "NP_001107588", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107588", "type": "external" } ], "gene_names_uniprotkb": "Syt3", "gene_names_refseq": "Syt3; sytIII", "protein_names_uniprotkb": "Synaptotagmin-3; Synaptotagmin III; SytIII", "protein_names_refseq": "synaptotagmin-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:20981)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10531343;10531344;21750661;24129315;27399837;33300544;36261524;36892998", "class_list": "", "function": "Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis. Plays a role in dendrite formation by melanocytes., [UniProtKB, UniProtKB, UniProtKB]; Fast resupply of synaptic vesicles requires synaptotagmin-3., [RefSeq, PubMed]; Synaptotagmin-3 interactions with GluA2 mediate brain damage and impair functional recovery in stroke., [RefSeq, PubMed]; The combined inactivation of all 3 E-Syt genes has no effect on mouse viability or fertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97791;Q80WV1", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0030658 transport vesicle membrane;GO:0098794 postsynapse;GO:0097060 synaptic membrane", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0030154 cell differentiation;GO:0051592 response to calcium ion;GO:0007268 chemical synaptic transmission;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O35681-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R173-1", "uniprot_id": [ { "id": "ZDHC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R173", "type": "external" } ], "mass": 34041.0, "length": 299, "protein_name": "Palmitoyltransferase ZDHHC3", "gene_name": "Zdhhc3", "organism": "Mouse", "refseq_name": "palmitoyltransferase ZDHHC3 isoform 2", "refseq_ac": [ { "id": "NP_081193", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081193", "type": "external" } ], "gene_names_uniprotkb": "Zdhhc3; Godz; Gramp1", "gene_names_refseq": "1110020O22Rik; 1810006O10Rik; 2210017C02Rik; DHHC-3; GODZ; Gramp1; Zdhhc3; Zfp373", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC3; 2.3.1.-; 2.3.1.225; Acyltransferase ZDHHC3; DHHC-3; GABA-A receptor-associated membrane protein 1; Golgi-specific DHHC zinc finger protein; Zinc finger DHHC domain-containing protein 3", "protein_names_refseq": "GABA-A receptor-associated membrane protein 1; acyltransferase ZDHHC3; golgi-specific DHHC zinc finger protein; palmitoyltransferase ZDHHC3 isoform 2; palmitoyltransferase ZDHHC3; zinc finger DHHC domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:69035)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "12163046;15229235;15603741;16129400;17151279;18596047;19001095;19955568;21750661;23687301;23793055;25253725;25428506;26487721;27247265;27613864;27875292;28167757;28734079;30084848;33788965;34428180;37544897;39327467", "class_list": "", "function": "GODZ-mediated palmitoylation is a novel posttranslational modification that is selective for gamma-subunit-containing GABA(A) receptor subtypes, a mechanism that may be important for regulated trafficking of these receptors in the secretory pathway., [RefSeq, PubMed]; GODZ-mediated palmitoylation of GABA(A) receptor gamma 2 subunit, and possibly other substrates, contributes selectively to the formation and normal function of GABAergic inhibitory synapses., [RefSeq, PubMed]; Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:15229235, PubMed:15603741, PubMed:16129400, PubMed:19001095, PubMed:23793055, PubMed:25253725, PubMed:26487721). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (Probable). Plays an important role in G protein-coupled receptor signaling pathways involving GNAQ and potentially other heterotrimeric G proteins by regulating their dynamic association with the plasma membrane (PubMed:19001095). Palmitoylates ITGA6 and ITGB4, thereby regulating the alpha-6/beta-4 integrin localization, expression and function in cell adhesion to laminin (By similarity). Plays a role in the TRAIL-activated apoptotic signaling pathway most probably through the palmitoylation and localization to the plasma membrane of TNFRSF10A (By similarity). In the brain, by palmitoylating the gamma subunit GABRG2 of GABA(A) receptors and regulating their postsynaptic accumulation, plays a role in synaptic GABAergic inhibitory function and GABAergic innervation (PubMed:15229235, PubMed:17151279, PubMed:27875292). Palmitoylates the neuronal protein GAP43 which is also involved in the formation of GABAergic synapses (PubMed:27875292). Palmitoylates NCDN thereby regulating its association with endosome membranes (PubMed:23687301). Probably palmitoylates PRCD and is involved in its proper localization within the photoreceptor (PubMed:27613864). Could mediate the palmitoylation of NCAM1 and regulate neurite outgrowth (PubMed:27247265). Could palmitoylate DNAJC5 and regulate its localization to Golgi membranes (PubMed:18596047). Also constitutively palmitoylates DLG4 (PubMed:15603741). May also palmitoylate SNAP25 (PubMed:25253725). Could palmitoylate the glutamate receptors GRIA1 and GRIA2 but this has not been confirmed in vivo (PubMed:16129400, PubMed:27875292). Could also palmitoylate the D(2) dopamine receptor DRD2 (By similarity). May also palmitoylate LAMTOR1, promoting its localization to lysosomal membranes (By similarity). Palmitoylates the Toll-like receptor 9/TLR9 in the Golgi and thereby regulates TLR9 trafficking to endosomes (By similarity). May palmitoylate CALHM1 and CALHM3 subunits of gustatory voltage-gated ion channels and modulate channel gating and kinetics (PubMed:33788965). Catalyzes the palmitoylation of CADM4 at 'Cys-347', ensuring its localization to the plasma membrane (PM) and protein stability (PubMed:39327467). The presence of CADM4 at the PM is essential for its function in CNS myelination, particularly through its associations with other cell adhesion molecules (PubMed:39327467)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; IFI27 Integrates Succinate and Fatty Acid Oxidation to Promote Adipocyte Thermogenic Adaption., [RefSeq, PubMed]; May also function as a calcium transporter., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6EMK3", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity;GO:0019705 protein-cysteine S-myristoyltransferase activity;GO:0140439 protein-cysteine S-stearoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0072659 protein localization to plasma membrane;GO:0006605 protein targeting;GO:0006612 protein targeting to membrane;GO:0032230 positive regulation of synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q8R173-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JL25-1", "uniprot_id": [ { "id": "RGS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JL25", "type": "external" } ], "mass": 24107.0, "length": 209, "protein_name": "Regulator of G protein signaling 1", "gene_name": "Rgs1", "organism": "Mouse", "refseq_name": "regulator of G-protein signaling 1", "refseq_ac": [ { "id": "NP_056626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056626", "type": "external" } ], "gene_names_uniprotkb": "Rgs1", "gene_names_refseq": "BL34; Rgs1", "protein_names_uniprotkb": "Regulator of G protein signaling 1; RGS1", "protein_names_refseq": "regulator of G-protein signaling 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:50778); (R-MMU-416476); (R-MMU-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10779778;21750661;34428180;34852285;37153600;37696381", "class_list": "", "function": "Inhibiting RGS1 attenuates secondary inflammation response and tissue degradation via the TLR/TRIF/NF-kappaB pathway in macrophage post spinal cord injury., [RefSeq, PubMed]; RGS1 mediates renal interstitial fibrosis through activation of the inflammatory response., [RefSeq, PubMed]; Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12 (PubMed:10779778). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (By similarity)., [UniProtKB, UniProtKB, PubMed]; Regulator of G-protein signaling 1 critically supports CD8[+] TRM cell-mediated intestinal immunity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBD1;Q3TC18;Q3TD56;Q3U477", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0043547 positive regulation of GTPase activity;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JL25-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58735-1", "uniprot_id": [ { "id": "S26A1_MOUSE", "url": "https://www.uniprot.org/uniprot/P58735", "type": "external" } ], "mass": 75788.0, "length": 704, "protein_name": "Sulfate anion transporter 1", "gene_name": "Slc26a1", "organism": "Mouse", "refseq_name": "sulfate anion transporter 1 isoform 2", "refseq_ac": [ { "id": "NP_001297621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297621", "type": "external" } ], "gene_names_uniprotkb": "Slc26a1; Sat1", "gene_names_refseq": "Sat1; Slc26a1", "protein_names_uniprotkb": "Sulfate anion transporter 1; SAT-1; Solute carrier family 26 member 1", "protein_names_refseq": "sulfate anion transporter 1 isoform 2; sulfate anion transporter 1", "tax_id": 10090, "disease": "calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652)", "pathway": " (mmu:231583); (R-MMU-174362); (R-MMU-427601)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "12217875;12590734;17242355;20160351;21183079;21750661;22517357;27210743;30059200;30084848;30383413;34428180;38111663", "class_list": "glycogene", "function": "First characterization of the structure and regulation of the Sat1 gene encoding a SO(4)(2-)/chloride/oxalate anion transporter, [RefSeq, PubMed]; Sat1 regulates both oxalate and sulfate homeostasis and may be critical to the development of calcium oxalate urolithiasis and hepatotoxicity., [RefSeq, PubMed]; Slc26a1 is not essential for spermatogenesis and male fertility in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Sodium-independent sulfate anion transporter (PubMed:12217875, PubMed:12590734, PubMed:20160351, PubMed:27210743). Can transport other anions including bicarbonate, thiosulfate and oxalate by mediating sulfate-hydrogencarbonate, sulfate-oxalate and oxalate-hydrogencarbonate anion exchange (PubMed:12217875, PubMed:12590734, PubMed:20160351, PubMed:27210743). Mediates sulfate-thiosulfate anion exchange (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Study concludes that a DIDS-sensitive basolateral transporter is involved in mediating oxalate secretion across mouse duodenum, but Sat1 itself is dispensable for this process, [RefSeq, PubMed]; That SAT-1 has a major role in oxalate excretion via the intestine, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 36, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q80WF6", "ec_number_list": [], "go_molecular_function": "GO:0005452 solute:inorganic anion antiporter activity;GO:0015108 chloride transmembrane transporter activity;GO:0019531 oxalate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity;GO:0140900 chloride:bicarbonate antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0019532 oxalate transport;GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport;GO:1902358 sulfate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P58735-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000010001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62203-1", "uniprot_id": [ { "id": "SF3A2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62203", "type": "external" } ], "mass": 49911.0, "length": 475, "protein_name": "Splicing factor 3A subunit 2", "gene_name": "Sf3a2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sf3a2; Sap62", "gene_names_refseq": "", "protein_names_uniprotkb": "Splicing factor 3A subunit 2; SAP 62; SF3a66; Spliceosome-associated protein 62", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:20222); (R-MMU-72163); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11602354;21750661;23806337;26495903;31219806;37507081;40997131;8541848", "class_list": "", "function": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A2 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex. Interacts directly with the duplex formed by U2 snRNA and the intron., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0000375 RNA splicing, via transesterification reactions;GO:0006397 mRNA processing;GO:0010976 positive regulation of neuron projection development;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q62203-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0N8-1", "uniprot_id": [ { "id": "SYT6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0N8", "type": "external" } ], "mass": 57204.0, "length": 511, "protein_name": "Synaptotagmin-6", "gene_name": "Syt6", "organism": "Mouse", "refseq_name": "synaptotagmin-6 isoform 1", "refseq_ac": [ { "id": "NP_061270", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061270", "type": "external" } ], "gene_names_uniprotkb": "Syt6", "gene_names_refseq": "3110037A08Rik; Syt6; sytVI", "protein_names_uniprotkb": "Synaptotagmin-6; Synaptotagmin VI; SytVI", "protein_names_refseq": "synaptotagmin-6 isoform 1; synaptotagmin-6", "tax_id": 10090, "disease": "", "pathway": " (mmu:54524)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10531343;10531344;10871604;15774481;21750661", "class_list": "", "function": "May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (PubMed:15774481)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QJV2;Q9QUK7", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0048306 calcium-dependent protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0097038 perinuclear endoplasmic reticulum", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0007340 acrosome reaction;GO:0016192 vesicle-mediated transport;GO:0017158 regulation of calcium ion-dependent exocytosis;GO:0060478 acrosomal vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9R0N8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62281-1", "uniprot_id": [ { "id": "RS11_MOUSE", "url": "https://www.uniprot.org/uniprot/P62281", "type": "external" } ], "mass": 18431.0, "length": 158, "protein_name": "Small ribosomal subunit protein uS17", "gene_name": "Rps11", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS17", "refseq_ac": [ { "id": "NP_038753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038753", "type": "external" } ], "gene_names_uniprotkb": "Rps11", "gene_names_refseq": "Rps11", "protein_names_uniprotkb": "Small ribosomal subunit protein uS17; 40S ribosomal protein S11", "protein_names_refseq": "40S ribosomal protein S11; small ribosomal subunit protein uS17", "tax_id": 10090, "disease": "", "pathway": " (mmu:27207); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 18, "publication_id_list": "10580157;21750661;22645316;23806337;24129315;24463520;24788674;25605945;34428180;35820727;35984892;36210013;36288343;36517592;37453647;39627609;39927985;40997131", "class_list": "", "function": "Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, PubMed]; Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P04643", "ec_number_list": [], "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse;GO:0005840 ribosome", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis;GO:0140236 translation at presynapse;GO:0140242 translation at postsynapse;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P62281-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TIR3-1", "uniprot_id": [ { "id": "RIC8A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TIR3", "type": "external" } ], "mass": 59847.0, "length": 530, "protein_name": "Chaperone Ric-8A", "gene_name": "Ric8a", "organism": "Mouse", "refseq_name": "chaperone Ric-8A", "refseq_ac": [ { "id": "NP_444424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444424", "type": "external" } ], "gene_names_uniprotkb": "Ric8a; Ric8", "gene_names_refseq": "RIC-8; Ric8a; Ric8", "protein_names_uniprotkb": "Chaperone Ric-8A; Synembryn-A", "protein_names_refseq": "chaperone Ric-8A; resistance to inhibitors of cholinesterase 8 homolog; synembryn-A", "tax_id": 10090, "disease": "", "pathway": " (mmu:101489)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10985349;12971991;16221497;16629901;17242355;21158412;21183079;21750661;22114146;29380551;29844055;30084848;31219806;34039624;34428180", "class_list": "", "function": "Based on these results we can conclude the importance of ric-8 in the regulation of memory and emotional behavior., [RefSeq, PubMed]; Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ (PubMed:22114146). Does not fold G(s) G-alpha proteins GNAS nor GNAL (PubMed:22114146). Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP (By similarity). Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; CircPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1., [RefSeq, PubMed]; Here we show that during the early development in mice (E9.5-E12.0) ric-8 (synembryn) is expressed in the developing nervous system, [RefSeq, PubMed]; In conditional Ric8a knockout mice the absence of RIC8A severely affected the attachment and positioning of radial glial processes, Cajal-Retzius' cells, and the arachnoid trabeculae, and these mice displayed additional defects in the lens, skeletal muscles, and heart development. All the discovered defects might be linked to aberrancies in cell adhesion and migration., [RefSeq, PubMed]; These results suggested that Ric-8A potentiates Gq-mediated signal transduction by acting as a novel-type regulator in intact cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEY3;Q99JW0;Q9ERR6", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0001965 G-protein alpha-subunit binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0016020 membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0008542 visual learning;GO:0042074 cell migration involved in gastrulation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q3TIR3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXW4-1", "uniprot_id": [ { "id": "RL11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXW4", "type": "external" } ], "mass": 20252.0, "length": 178, "protein_name": "Large ribosomal subunit protein uL5", "gene_name": "Rpl11", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL5", "refseq_ac": [ { "id": "NP_080195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080195", "type": "external" } ], "gene_names_uniprotkb": "Rpl11", "gene_names_refseq": "2010203J19Rik; Rpl11", "protein_names_uniprotkb": "Large ribosomal subunit protein uL5; 60S ribosomal protein L11", "protein_names_refseq": "60S ribosomal protein L11; large ribosomal subunit protein uL5", "tax_id": 10090, "disease": "Diamond-Blackfan anemia 7 (Disease Ontology:DOID:0111878); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603)", "pathway": " (mmu:67025); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 17, "publication_id_list": "15195100;21750661;21804542;22645316;25605945;30084848;33300544;34428180;35820727;35984892;36210013;36435197;36517592;37453647;37507081;37828378;39627609", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:36517592). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:36517592). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:36517592). As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:36517592). It also couples ribosome biogenesis to p53/TP53 activation (PubMed:21804542). As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:21804542). Promotes nucleolar location of PML (PubMed:15195100)., [UniProtKB, PubMed, PubMed, PubMed]; Ribosomal protein RPL11 haploinsufficiency causes anemia in mice via activation of the RP-MDM2-p53 pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPE3;Q6ZWY0", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0031625 ubiquitin protein ligase binding;GO:0042975 peroxisome proliferator activated receptor binding;GO:1990948 ubiquitin ligase inhibitor activity;GO:0008097 5S rRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0010628 positive regulation of gene expression;GO:0006605 protein targeting;GO:0042273 ribosomal large subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9CXW4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14148-1", "uniprot_id": [ { "id": "RL7_MOUSE", "url": "https://www.uniprot.org/uniprot/P14148", "type": "external" } ], "mass": 31420.0, "length": 270, "protein_name": "Large ribosomal subunit protein uL30", "gene_name": "Rpl7", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL30", "refseq_ac": [ { "id": "NP_035421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035421", "type": "external" } ], "gene_names_uniprotkb": "Rpl7", "gene_names_refseq": "Rpl7a; Rpl7; Surf-3", "protein_names_uniprotkb": "Large ribosomal subunit protein uL30; 60S ribosomal protein L7", "protein_names_refseq": "60S ribosomal protein L7; large ribosomal subunit protein uL30", "tax_id": 10090, "disease": "", "pathway": " (mmu:19989); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 24, "publication_id_list": "16393994;21750661;2365680;23806337;25428506;25605945;26100019;26495903;26740625;28011936;30084848;31219806;33300544;34428180;35820727;36210013;36288343;36517592;37453647;37507081;37828378;39627609;39927985;8441630", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Binds to G-rich structures in 28S rRNA and in mRNAs (By similarity). Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity)., [UniProtKB, UniProtKB, PubMed]; Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80UR0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0042802 identical protein binding;GO:0008097 5S rRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0042273 ribosomal large subunit biogenesis;GO:0006412 translation;GO:0006941 striated muscle contraction", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P14148-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12970-1", "uniprot_id": [ { "id": "RL7A_MOUSE", "url": "https://www.uniprot.org/uniprot/P12970", "type": "external" } ], "mass": 29977.0, "length": 266, "protein_name": "Large ribosomal subunit protein eL8", "gene_name": "Rpl7a", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL8", "refseq_ac": [ { "id": "NP_038749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038749", "type": "external" } ], "gene_names_uniprotkb": "Rpl7a; Surf-3; Surf3", "gene_names_refseq": "Rpl7a; Surf3", "protein_names_uniprotkb": "Large ribosomal subunit protein eL8; 60S ribosomal protein L7a; Surfeit locus protein 3", "protein_names_refseq": "60S ribosomal protein L7a; large ribosomal subunit protein eL8; surfeit 3; surfeit locus protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:27176)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "19129230;25428506;25605945;29969783;30084848;31219806;3221868;33725478;34428180;34678516;35820727;36288343;36517592;37453647;37507081;39627609", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]; Findings reveal that the nuclear import of FKBP25 and binding with 60S ribosomal protein L7a are protective stress responses to ischemia/nitrosaive stress injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91YM3", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation;GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P12970-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48381-1", "uniprot_id": [ { "id": "RFX3_MOUSE", "url": "https://www.uniprot.org/uniprot/P48381", "type": "external" } ], "mass": 83512.0, "length": 749, "protein_name": "Transcription factor RFX3", "gene_name": "Rfx3", "organism": "Mouse", "refseq_name": "transcription factor RFX3 isoform 1", "refseq_ac": [ { "id": "NP_001159886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159886", "type": "external" } ], "gene_names_uniprotkb": "Rfx3", "gene_names_refseq": "C230093O12Rik; MRFX3; Rfx3", "protein_names_uniprotkb": "Transcription factor RFX3; Regulatory factor X 3", "protein_names_refseq": "regulatory factor X 3; transcription factor RFX3 isoform 1; transcription factor RFX3", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545)", "pathway": " (mmu:19726)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "15121860;15229132;16930429;17229940;19671664;20485683;21750661;25428506;30084848;31235600;32725242;34203471;34428180;35997120;8289803", "class_list": "", "function": "Downregulation of microRNA-342-3p Eases Insulin Resistance and Liver Gluconeogenesis via Regulating Rfx3 in Gestational Diabetes Mellitus., [RefSeq, PubMed]; Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis., [RefSeq, PubMed]; RFX3 is essential for the differentiation of nodal monocilia and hence for LR body axis determination., [RefSeq, PubMed]; These data suggest that Rnf20 functions at the Rfx3 locus regulating cilia motility and cardiac situs and identify H2Bub1 as an upstream transcriptional regulator controlling tissue-specific expression of cilia genes. Our findings mechanistically link the two functional gene ontologies that have been implicated in human CHD: chromatin remodeling and cilia function., [RefSeq, PubMed]; These results demonstrate that regulatory factor X3 is necessary for ciliated ependymal cell differentiation in the mouse., [RefSeq, PubMed]; Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells (PubMed:15121860, PubMed:19671664). Also required for ciliated ependymal cell differentiation (PubMed:16930429). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells (PubMed:17229940). Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (By similarity). Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5). Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLW2;Q8C0R3;Q8VBY6", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0072560 type B pancreatic cell maturation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P48381-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63323-1", "uniprot_id": [ { "id": "RS12_MOUSE", "url": "https://www.uniprot.org/uniprot/P63323", "type": "external" } ], "mass": 14515.0, "length": 132, "protein_name": "Small ribosomal subunit protein eS12", "gene_name": "Rps12", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein eS12 isoform a", "refseq_ac": [ { "id": "NP_035425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035425", "type": "external" } ], "gene_names_uniprotkb": "Rps12", "gene_names_refseq": "Rps12", "protein_names_uniprotkb": "Small ribosomal subunit protein eS12; 40S ribosomal protein S12", "protein_names_refseq": "40S ribosomal protein S12; small ribosomal subunit protein eS12 isoform a; small ribosomal subunit protein eS12", "tax_id": 10090, "disease": "", "pathway": " (mmu:20042); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 10, "publication_id_list": "12477932;21540332;21750661;22645316;23806337;2780296;28528544;36288343;37272618;37507081", "class_list": "", "function": "Haploinsufficiency of the essential gene Rps12 causes defects in erythropoiesis and hematopoietic stem cell maintenance. Publication Status: Online-Only, [RefSeq, PubMed]; Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Subunit of the 40S ribosomal complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P09388;P12728;Q6ZWZ6", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse", "go_biological_process": "GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:1990145 maintenance of translational fidelity;GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis;GO:0140236 translation at presynapse", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P63323-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3URD2-1", "uniprot_id": [ { "id": "RPRML_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3URD2", "type": "external" } ], "mass": 12348.0, "length": 117, "protein_name": "Reprimo-like protein", "gene_name": "Rprml", "organism": "Mouse", "refseq_name": "reprimo-like protein", "refseq_ac": [ { "id": "NP_001028384", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028384", "type": "external" } ], "gene_names_uniprotkb": "Rprml", "gene_names_refseq": "Rprml", "protein_names_uniprotkb": "Reprimo-like protein", "protein_names_refseq": "reprimo-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:104582)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3URD2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69ZJ7-1", "uniprot_id": [ { "id": "RIC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69ZJ7", "type": "external" } ], "mass": 158829.0, "length": 1422, "protein_name": "Guanine nucleotide exchange factor subunit RIC1", "gene_name": "Ric1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ric1; C030046E11Rik; Kiaa1432", "gene_names_refseq": "", "protein_names_uniprotkb": "Guanine nucleotide exchange factor subunit RIC1; Protein RIC1 homolog; RAB6A-GEF complex partner protein 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:226089); (R-MMU-6811438); (R-MMU-6811440); (R-MMU-8876198)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "21183079;21750661;25428506;27878435;31219806;31599954;34428180", "class_list": "", "function": "The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may thereby be required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. Is a regulator of procollagen transport and secretion, and is required for correct cartilage morphogenesis and development of the craniofacial skeleton., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4GZ02;Q3U0Q6;Q3UWK1", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0034066 Ric1-Rgp1 guanyl-nucleotide exchange factor complex;GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0016020 membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0006886 intracellular protein transport;GO:0043547 positive regulation of GTPase activity;GO:0042147 retrograde transport, endosome to Golgi;GO:0042177 negative regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q69ZJ7-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AIW0-1", "uniprot_id": [ { "id": "ENTR1_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AIW0", "type": "external" } ], "mass": 48025.0, "length": 432, "protein_name": "Endosome-associated-trafficking regulator 1", "gene_name": "Entr1", "organism": "Mouse", "refseq_name": "endosome-associated-trafficking regulator 1 isoform 3", "refseq_ac": [ { "id": "NP_001078876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078876", "type": "external" } ], "gene_names_uniprotkb": "Entr1; Sdccag3", "gene_names_refseq": "C330016H24Rik; C630038K21Rik; Entr1; Sdccag3", "protein_names_uniprotkb": "Endosome-associated-trafficking regulator 1; Serologically defined colon cancer antigen 3", "protein_names_refseq": "endosome-associated-trafficking regulator 1 isoform 3; serologically defined colon cancer antigen 3 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68112)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16332174;21183079;21750661;23108400;27373827;27767179", "class_list": "", "function": "Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis. Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1. Plays a role in the formation of cilia. Involved in cargo protein localization, such as PKD2, at primary cilia (By similarity). Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (PubMed:16332174)., [UniProtKB, PubMed, UniProtKB]; May be involved in modulation of TNF response. May be involved in presentation of TNFRSF1A on the cell surface (PubMed:16332174). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (By similarity)., [UniProtKB, PubMed, UniProtKB]; SDCCAG3 has a role in ciliogenesis and in localization of cargo to primary cilia Publication Status: Online-Only, [RefSeq, PubMed]; These findings suggest that SDCCAG3 might function in endosomal trafficking downstream of Arf6., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AIW1;Q3TQC5;Q6P8W2;Q8BIV5;Q8K0I8;Q9D1V2;Q9D4S1;Q9D5W1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005813 centrosome;GO:0055037 recycling endosome;GO:0030496 midbody", "go_biological_process": "GO:0015031 protein transport;GO:0051301 cell division;GO:0030030 cell projection organization;GO:0032456 endocytic recycling;GO:1903566 positive regulation of protein localization to cilium", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A2AIW0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PGE7-1", "uniprot_id": [ { "id": "SC6A7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PGE7", "type": "external" } ], "mass": 71066.0, "length": 637, "protein_name": "Sodium-dependent proline transporter", "gene_name": "Slc6a7", "organism": "Mouse", "refseq_name": "sodium-dependent proline transporter isoform 1", "refseq_ac": [ { "id": "NP_958741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958741", "type": "external" } ], "gene_names_uniprotkb": "Slc6a7", "gene_names_refseq": "PROT; Slc6a7", "protein_names_uniprotkb": "Sodium-dependent proline transporter; Solute carrier family 6 member 7", "protein_names_refseq": "sodium-dependent proline transporter isoform 1; sodium-dependent proline transporter; solute carrier family 6 member 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:240332); (R-MMU-442660); (R-MMU-71288)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;19029042;21183079", "class_list": "", "function": "Brain specific sodium (and chloride)-dependent proline transporter. Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals., [UniProtKB, UniProtKB]; We assessed two candidates for the betaine/proline transporter: SIT1 (IMINO; encoded by Slc6a20a) and PROT (Slc6a7). mRNA from both genes was present in eggs and 1-cell embryos., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80UM1", "ec_number_list": [], "go_molecular_function": "GO:0015193 L-proline transmembrane transporter activity;GO:0005298 proline:sodium symporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0030672 synaptic vesicle membrane;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0015824 proline transport;GO:0035524 proline transmembrane transport;GO:0035725 sodium ion transmembrane transport;GO:0030163 protein catabolic process;GO:0006836 neurotransmitter transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6PGE7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80UK7-1", "uniprot_id": [ { "id": "SAS6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80UK7", "type": "external" } ], "mass": 74054.0, "length": 654, "protein_name": "Spindle assembly abnormal protein 6 homolog", "gene_name": "Sass6", "organism": "Mouse", "refseq_name": "spindle assembly abnormal protein 6 homolog isoform 3", "refseq_ac": [ { "id": "NP_001276497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276497", "type": "external" } ], "gene_names_uniprotkb": "Sass6; Sas6", "gene_names_refseq": "2810453L12Rik; SAS-6; Sass6", "protein_names_uniprotkb": "Spindle assembly abnormal protein 6 homolog; SAS-6; Spindle assembly defective protein 6", "protein_names_refseq": "spindle assembly 6 homolog; spindle assembly abnormal protein 6 homolog isoform 3; spindle assembly abnormal protein 6 homolog; spindle assembly defective protein 6", "tax_id": 10090, "disease": "primary autosomal recessive microcephaly 14 (Disease Ontology:DOID:0070279)", "pathway": " (mmu:72776)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;24240477;30084848;31219806;32782141;36852467;38407237", "class_list": "", "function": "Central scaffolding component of the centrioles ensuring their 9-fold symmetry (By similarity). Required for centrosome biogenesis and duplication (PubMed:24240477, PubMed:38407237). Required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (PubMed:24240477). Not required for centriole formation in embryonic stem cells but necessary to maintain centriole architecture (PubMed:38407237). Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9CYT4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005814 centriole;GO:0098536 deuterosome;GO:0120099 procentriole replication complex", "go_biological_process": "GO:0046601 positive regulation of centriole replication;GO:1905832 positive regulation of spindle assembly;GO:0007283 spermatogenesis;GO:1900087 positive regulation of G1/S transition of mitotic cell cycle;GO:0060236 regulation of mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q80UK7-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z132-1", "uniprot_id": [ { "id": "RSPO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z132", "type": "external" } ], "mass": 29332.0, "length": 265, "protein_name": "R-spondin-1", "gene_name": "Rspo1", "organism": "Mouse", "refseq_name": "R-spondin-1 precursor", "refseq_ac": [ { "id": "NP_619624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619624", "type": "external" } ], "gene_names_uniprotkb": "Rspo1", "gene_names_refseq": "R-spondin; Rspo1; Rspondin", "protein_names_uniprotkb": "R-spondin-1; Cristin-3; Cysteine-rich and single thrombospondin domain-containing protein 3; Roof plate-specific spondin-1; mCristin-3", "protein_names_refseq": "R-spondin homolog; R-spondin-1 precursor; cristin-3; cysteine-rich and single thrombospondin domain-containing protein 3; mCristin-3; roof plate-specific spondin-1; thrombospondin type 1 domain containing gene Rspondin", "tax_id": 10090, "disease": "type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:192199); (R-MMU-4641263)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14732490;15469841;16543246;17041600;21693646;21750661;38376238", "class_list": "", "function": "Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes (PubMed:21693646). Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination (By similarity). Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1 (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Inefficient Sox9 upregulation and absence of Rspo1 repression lead to sex reversal in the B6.XYTIR mouse gonaddagger., [RefSeq, PubMed]; R-spondin might be a novel marker of the boundary between the roof plate and neuroepithelium and may contribute to the development of dorsal neural tube under the regulation of Wnts., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 2, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1S3", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005576 extracellular region", "go_biological_process": "GO:1903999 negative regulation of eating behavior;GO:2000254 regulation of male germ cell proliferation;GO:0001934 positive regulation of protein phosphorylation;GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z132-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000011100.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR88-1", "uniprot_id": [ { "id": "RT14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR88", "type": "external" } ], "mass": 14920.0, "length": 128, "protein_name": "Small ribosomal subunit protein uS14m", "gene_name": "Mrps14", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS14m isoform 1", "refseq_ac": [ { "id": "NP_079750", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079750", "type": "external" } ], "gene_names_uniprotkb": "Mrps14", "gene_names_refseq": "1810032L21Rik; Mrps14; Rpms14", "protein_names_uniprotkb": "Small ribosomal subunit protein uS14m; 28S ribosomal protein S14, mitochondrial; MRP-S14; S14mt", "protein_names_refseq": "28S ribosomal protein S14, mitochondrial; MRP-S14; S14mt; small ribosomal subunit protein uS14m isoform 1; small ribosomal subunit protein uS14m", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 38 (Disease Ontology:DOID:0111466)", "pathway": " (mmu:64659); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "21750661;21952136;25369936;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNI7", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031965 nuclear membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CR88-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02614-1", "uniprot_id": [ { "id": "S30BP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q02614", "type": "external" } ], "mass": 33832.0, "length": 308, "protein_name": "SAP30-binding protein", "gene_name": "Sap30bp", "organism": "Mouse", "refseq_name": "SAP30-binding protein isoform 1", "refseq_ac": [ { "id": "NP_065229", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065229", "type": "external" } ], "gene_names_uniprotkb": "Sap30bp; Hcngp", "gene_names_refseq": "2700016D05Rik; Hcngp; Sap30bp", "protein_names_uniprotkb": "SAP30-binding protein; Transcriptional regulator protein HCNGP", "protein_names_refseq": "SAP30-binding protein isoform 1; transcriptional regulator protein (Hcngp); transcriptional regulator protein HCNGP", "tax_id": 10090, "disease": "", "pathway": " (mmu:57230)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;1459361;21183079;21606357;22517741;22645316;23443134;25428506;25428507;25605945;26192747;29125738;30059200;30084848;30779550;32782141;32848054;34428180;34678516;35822049;36852467;37828378;40021952;40885482;40997131", "class_list": "", "function": "Plays a role in transcriptional repression by promoting histone deacetylase activity, leading to deacetylation of histone H3 (By similarity). Acts as a regulator of pre-mRNA splicing by facilitating assembly of the cyclin-L-CDK11 cyclin-dependent protein kinase complex, thereby promoting phosphorylation of SF3B1 (By similarity). May be involved in the regulation of beta-2-microglobulin genes (PubMed:1459361)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 18, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 18, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 18, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "Q8VDJ5", "ec_number_list": [], "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0045111 intermediate filament cytoskeleton", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0006355 regulation of DNA-templated transcription;GO:0009615 response to virus;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "Q02614-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQX8-1", "uniprot_id": [ { "id": "KGD4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQX8", "type": "external" } ], "mass": 11101.0, "length": 102, "protein_name": "Alpha-ketoglutarate dehydrogenase component 4", "gene_name": "Kgd4", "organism": "Mouse", "refseq_name": "alpha-ketoglutarate dehydrogenase component 4 isoform 1", "refseq_ac": [ { "id": "NP_079645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079645", "type": "external" } ], "gene_names_uniprotkb": "Kgd4; Mrps36", "gene_names_refseq": "1110018B13Rik; Kdg4; Kgd4; Mrps36; S36mt", "protein_names_uniprotkb": "Alpha-ketoglutarate dehydrogenase component 4; Alpha-ketoglutarate dehydrogenase subunit 4", "protein_names_refseq": "28S ribosomal protein S36, mitochondrial; alpha-ketoglutarate dehydrogenase component 4 isoform 1; alpha-ketoglutarate dehydrogenase component 4; mitochondrial ribosomal protein S36", "tax_id": 10090, "disease": "", "pathway": " (mmu:66128); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-6783984); (R-MMU-9853506); (R-MMU-9937383)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "17242355;21183079;23806337;25165143;25605945;36288343;36854377", "class_list": "", "function": "Molecular adapter that is necessary to form a stable 2-oxoglutarate dehydrogenase enzyme complex (OGDHC). Enables the specific recruitment of E3 subunit to E2 subunit in the 2-oxoglutarate dehydrogenase complex (OGDHC)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4VA25", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0045252 oxoglutarate dehydrogenase complex", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006103 2-oxoglutarate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CQX8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIK9-1", "uniprot_id": [ { "id": "RT34_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIK9", "type": "external" } ], "mass": 25827.0, "length": 218, "protein_name": "Small ribosomal subunit protein mS34", "gene_name": "Mrps34", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein mS34", "refseq_ac": [ { "id": "NP_075749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075749", "type": "external" } ], "gene_names_uniprotkb": "Mrps34; Tce2", "gene_names_refseq": "0610007F04Rik; 5330430D13Rik; Mrps34; Tce2", "protein_names_uniprotkb": "Small ribosomal subunit protein mS34; 28S ribosomal protein S34, mitochondrial; MRP-S34; S34mt; T-complex expressed gene 2 protein", "protein_names_refseq": "28S ribosomal protein S34, mitochondrial; MRP-S34; S34mt; T-complex expressed gene 2 protein; small ribosomal subunit protein mS34", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 32 (Disease Ontology:DOID:0111492)", "pathway": " (mmu:79044); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10899141;25816300;35820727", "class_list": "", "function": "Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation., [UniProtKB, PubMed]; The Mrps34 mutation causes tissue-specific molecular changes that result in heterogeneous pathology involving alterations in fractional shortening of the heart and pronounced liver dysfunction that is exacerbated with age Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D2B0;Q9D957", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JIK9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJ05-1", "uniprot_id": [ { "id": "ZC3HE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJ05", "type": "external" } ], "mass": 82409.0, "length": 735, "protein_name": "Zinc finger CCCH domain-containing protein 14", "gene_name": "Zc3h14", "organism": "Mouse", "refseq_name": "zinc finger CCCH domain-containing protein 14 isoform b", "refseq_ac": [ { "id": "NP_001008506", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008506", "type": "external" } ], "gene_names_uniprotkb": "Zc3h14", "gene_names_refseq": "1010001P15Rik; 1700016A15Rik; 2700069A02Rik; Zc3h14", "protein_names_uniprotkb": "Zinc finger CCCH domain-containing protein 14", "protein_names_refseq": "zinc finger CCCH domain-containing protein 14 isoform b; zinc finger CCCH domain-containing protein 14", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308); autosomal recessive intellectual developmental disorder 56 (Disease Ontology:DOID:0081217); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:75553)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.3389/fragi.2021.757801;17242355;19303045;21183079;21734151;21750661;28666327;32782141;32848054;34428180;34678516;35822049;36852467;39461343;40885482;40997131", "class_list": "", "function": "Among the proteins increased in the hippocampi of Zc3h14Deltaex13/Deltaex13 mice compared to control are key synaptic proteins including CaMK2a. This newly generated mouse serves as a tool to study the function of ZC3H14 in vivo., [RefSeq, PubMed]; RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (By similarity). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (By similarity). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:28666327)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "A0PJE7;A1A4A9;Q3TU70;Q8BIY8;Q8R3Q8;Q8R3R2;Q9DAA8", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0008270 zinc ion binding;GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0032839 dendrite cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0048255 mRNA stabilization;GO:0043488 regulation of mRNA stability;GO:0160091 spliceosome-depend formation of circular RNA", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q8BJ05-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TZ9-1", "uniprot_id": [ { "id": "RERE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TZ9", "type": "external" } ], "mass": 171755.0, "length": 1558, "protein_name": "Arginine-glutamic acid dipeptide repeats protein", "gene_name": "Rere", "organism": "Mouse", "refseq_name": "arginine-glutamic acid dipeptide repeats protein", "refseq_ac": [ { "id": "NP_001078961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078961", "type": "external" } ], "gene_names_uniprotkb": "Rere; Atr2; Kiaa0458", "gene_names_refseq": "1110033A15Rik; ARG; ARP; ATN1L; Atr2; DNB1; Rere; eye; eyes3; mKIAA0458", "protein_names_uniprotkb": "Arginine-glutamic acid dipeptide repeats protein; Atrophin-2", "protein_names_refseq": "arginine-glutamic acid dipeptide repeats protein; atrophin-2", "tax_id": 10090, "disease": "dentatorubral-pallidoluysian atrophy (Disease Ontology:DOID:0060162)", "pathway": " (mmu:68703)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;14645126;17150957;17242355;21183079;21750661;22517741;23806337;25428506;29237092;30061196;30084848;31219806;33742727;33772547;34428180;34678516;36852467;40021952;40885482", "class_list": "", "function": "Act as transcriptional co-repressor during embryonic development., [RefSeq, PubMed]; Atrophin-1 and the short form of Atrophin-2 can act as potent and evolutionarily conserved transcriptional activators., [RefSeq, PubMed]; Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival., [UniProtKB, PubMed]; RERE deficiency causes retinal and optic nerve atrophy through degeneration of retinal cells., [RefSeq, PubMed]; RERE deficiency contributes to the development of orofacial clefts in humans and mice., [RefSeq, PubMed]; Rere and Gata4 interact genetically in the development of congenital heart defects. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "A2A7T4", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0016605 PML body;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0048755 branching morphogenesis of a nerve;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0048813 dendrite morphogenesis;GO:0021549 cerebellum development", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q80TZ9-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCC8-1", "uniprot_id": [ { "id": "RPGF3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCC8", "type": "external" } ], "mass": 103533.0, "length": 918, "protein_name": "Rap guanine nucleotide exchange factor 3", "gene_name": "Rapgef3", "organism": "Mouse", "refseq_name": "rap guanine nucleotide exchange factor 3 isoform 1", "refseq_ac": [ { "id": "NP_001171281", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171281", "type": "external" } ], "gene_names_uniprotkb": "Rapgef3; Epac1; Epac", "gene_names_refseq": "2310016P22Rik; 9330170P05Rik; Epac1; Epac; Rapgef3", "protein_names_uniprotkb": "Rap guanine nucleotide exchange factor 3; EPAC 1; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; cAMP-GEFI; cAMP-regulated guanine nucleotide exchange factor I", "protein_names_refseq": "Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; cAMP-GEFI; cAMP-regulated guanine nucleotide exchange factor I; exchange protein directly activated by cAMP 1; rap guanine nucleotide exchange factor 3 isoform 1; rap guanine nucleotide exchange factor 3", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:223864); (R-MMU-354192); (R-MMU-381676); (R-MMU-392517); (R-MMU-422356)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "12707305;12887090;16172130;17077580;20173027;21183079;21750661;25428506;30084848;38750790", "class_list": "", "function": "Epac is present in spermatogenic cells and exhibits a preferential subplasmalemmal localization; data show that cAMP activates Rap1 in differentiating male germ cells which express Epac, suggesting that this activation might occur directly through Epac, [RefSeq, PubMed]; Forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling, [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Leishmania exploits host cAMP/EPAC/calcineurin signaling to induce an IL-33-mediated anti-inflammatory environment for the establishment of infection., [RefSeq, PubMed]; Possible co-localization of Epac1 and Rap1 proteins in the heads of epididymal spermatozoa, [RefSeq, PubMed]; Rap1 plays a pivotal role in chemokine-induced integrin activation and migration. Rap1 was activated by secondary lymphoid tissue chemokine (SLC; CCL21) and stromal-derived factor 1 (CXCL4) treatment in lymphocytes within seconds., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZK9;Q8R1R1", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0044325 transmembrane transporter binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0030426 growth cone;GO:0043025 neuronal cell body", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0061028 establishment of endothelial barrier;GO:0032486 Rap protein signal transduction;GO:0001525 angiogenesis;GO:0001934 positive regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8VCC8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61124-1", "uniprot_id": [ { "id": "CLN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61124", "type": "external" } ], "mass": 47657.0, "length": 438, "protein_name": "Battenin", "gene_name": "Cln3", "organism": "Mouse", "refseq_name": "battenin isoform 1", "refseq_ac": [ { "id": "NP_001139783", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139783", "type": "external" } ], "gene_names_uniprotkb": "Cln3", "gene_names_refseq": "Cln3", "protein_names_uniprotkb": "Battenin; Protein CLN3", "protein_names_refseq": "battenin isoform 1; battenin; ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)", "tax_id": 10090, "disease": "neuronal ceroid lipofuscinosis 1 (Disease Ontology:DOID:0110721); neuronal ceroid lipofuscinosis 3 (Disease Ontology:DOID:0110731); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503)", "pathway": " (mmu:12752); (R-MMU-9845576)", "pathway_count": 2, "publication_count": 26, "publication_id_list": "10191118;10440905;10527801;11590129;12374761;15588329;16714284;17189291;17855597;17962032;18621045;19144319;19284480;19941651;20219947;21750661;24227717;24792215;25878248;26450516;29135436;29780879;31219806;34428180;8812504;9151313", "class_list": "", "function": "Mediates microtubule-dependent, anterograde transport connecting the Golgi network, endosomes, autophagosomes, lysosomes and plasma membrane, and participates in several cellular processes such as regulation of lysosomal pH, lysosome protein degradation, receptor-mediated endocytosis, autophagy, transport of proteins and lipids from the TGN, apoptosis and synaptic transmission (PubMed:10191118, PubMed:15588329, PubMed:16714284, PubMed:17855597, PubMed:24227717, PubMed:25878248, PubMed:26450516, PubMed:29780879). Facilitates the proteins transport from trans-Golgi network (TGN)-to other membrane compartments such as transport of microdomain-associated proteins to the plasma membrane, IGF2R transport to the lysosome where it regulates the CTSD release leading to regulation of CTSD maturation and thereby APP intracellular processing (PubMed:24227717). Moreover regulates CTSD activity in response to osmotic stress (By similarity). Also binds galactosylceramide and transports it from the trans Golgi to the rafts, which may have immediate and downstream effects on cell survival by modulating ceramide synthesis (PubMed:10191118). At the plasma membrane, regulates actin-dependent events including filopodia formation, cell migration, and pinocytosis through ARF1-CDC42 pathway and also the cytoskeleton organization through interaction with MYH10 and fodrin leading to the regulation of the plasma membrane association of Na+, K+ ATPase complex (PubMed:18621045, PubMed:24792215). Regulates synaptic transmission in the amygdala, hippocampus, and cerebellum through regulation of synaptic vesicles density and their proximity to active zones leading to modulation of short-term plasticity and age-dependent anxious behavior, learning and memory (PubMed:29135436, PubMed:29780879). Regulates autophagic vacuoles (AVs) maturation by modulating the trafficking between endocytic and autophagolysosomal/lysosomal compartments, which involves vesicle fusion leading to regulation of degradation process (PubMed:16714284, PubMed:25878248, PubMed:26450516). Also participates in cellular homeostasis of compounds such as, water, ions, amino acids, proteins and lipids in several tissue namely in brain and kidney through regulation of their transport and synthesis (PubMed:19284480, PubMed:20219947, PubMed:25878248)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a transmembrane protein called battenin that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis genes, cause a number of neurodegenerative diseases collectively known as neuronal ceroid lipofuscinoses, the most common of which is juvenile neuronal ceroid-lipofuscinosis (Batten disease). Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O35934;P70400", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0051861 glycolipid binding;GO:0120146 sulfatide binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome", "go_biological_process": "GO:0097352 autophagosome maturation;GO:2001288 positive regulation of caveolin-mediated endocytosis;GO:0010762 regulation of fibroblast migration;GO:0046836 glycolipid transport;GO:0048172 regulation of short-term neuronal synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q61124-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZWQ0-1", "uniprot_id": [ { "id": "SYNE2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZWQ0", "type": "external" } ], "mass": 782725.0, "length": 6874, "protein_name": "Nesprin-2", "gene_name": "Syne2", "organism": "Mouse", "refseq_name": "nesprin-2", "refseq_ac": [ { "id": "NP_001005510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005510", "type": "external" } ], "gene_names_uniprotkb": "Syne2", "gene_names_refseq": "6820443O06Rik; Cpfl8; D12Ertd777e; KASH2; NUA; Nesp2g; Syne2; dice; mKIAA1011", "protein_names_uniprotkb": "Nesprin-2; KASH domain-containing protein 2; KASH2; Nuclear envelope spectrin repeat protein 2; Nucleus and actin connecting element protein; Protein NUANCE; Synaptic nuclear envelope protein 2; Syne-2", "protein_names_refseq": "KASH domain-containing protein 2; diminished cone electroretinogram; nesprin 2; nesprin-2; nuance; nuclear envelope spectrin repeat protein 2; nucleus and actin connecting element protein; synaptic nuclear envelope 2; synaptic nuclear envelope protein 2", "tax_id": 10090, "disease": "autosomal dominant Emery-Dreifuss muscular dystrophy 5 (Disease Ontology:DOID:0070250); cryptorchidism (Disease Ontology:DOID:11383); Emery-Dreifuss muscular dystrophy (Disease Ontology:DOID:11726)", "pathway": " (mmu:319565)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;18299400;18477613;19596800;19874786;20484733;20724637;21177258;21183079;21540332;21750661;22872234;23071752;25428506;25605945;30084848;31219806;31599954;34428180;34678516;35820727;36210013;38569934", "class_list": "", "function": "Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 seem to act redundantly in cerebellum, midbrain, brain stem, and other brain regions except cerebral cortex and hippocampus. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in the cardiomyocyte sarcomere., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 9, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 3, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q640M5", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0140444 cytoskeleton-nuclear membrane anchor activity", "go_cellular_component": "GO:0031981 nuclear lumen;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0021817 nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration;GO:0031022 nuclear migration along microfilament;GO:0030335 positive regulation of cell migration;GO:0034504 protein localization to nucleus;GO:0006998 nuclear envelope organization", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q6ZWQ0-1", "record_type": "protein", "filter_code": "0000000.1100111.000010.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80VG1-1", "uniprot_id": [ { "id": "SCML4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80VG1", "type": "external" } ], "mass": 44445.0, "length": 408, "protein_name": "Sex comb on midleg-like protein 4", "gene_name": "Scml4", "organism": "Mouse", "refseq_name": "sex comb on midleg-like protein 4 isoform 2", "refseq_ac": [ { "id": "NP_766526", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766526", "type": "external" } ], "gene_names_uniprotkb": "Scml4", "gene_names_refseq": "9330161D17; Scml4; mFLJ00197", "protein_names_uniprotkb": "Sex comb on midleg-like protein 4", "protein_names_refseq": "sex comb on midleg-like 4; sex comb on midleg-like protein 4 isoform 2; sex comb on midleg-like protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:268297)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TA16;Q3V358;Q5DU61;Q8CC08", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80VG1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88427-1", "uniprot_id": [ { "id": "CAC1H_MOUSE", "url": "https://www.uniprot.org/uniprot/O88427", "type": "external" } ], "mass": 262030.0, "length": 2365, "protein_name": "Voltage-dependent T-type calcium channel subunit alpha-1H", "gene_name": "Cacna1h", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cacna1h; Kiaa1120", "gene_names_refseq": "", "protein_names_uniprotkb": "Voltage-dependent T-type calcium channel subunit alpha-1H; Voltage-gated calcium channel subunit alpha Cav3.2", "protein_names_refseq": "", "tax_id": 10090, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); childhood absence epilepsy (Disease Ontology:DOID:1825); primary hyperaldosteronism (Disease Ontology:DOID:446)", "pathway": " (mmu:58226)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;20173027;21750661;22872234;27149520;30084848;30779550;32826759;34428180;36210013;9670923", "class_list": "", "function": "Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons. In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 2, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "B2RQQ0;E9QNT0;Q80TJ2;Q9JKU5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0097110 scaffold protein binding;GO:0005244 voltage-gated monoatomic ion channel activity;GO:0005245 voltage-gated calcium channel activity;GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:0042391 regulation of membrane potential;GO:0055085 transmembrane transport;GO:0006816 calcium ion transport;GO:0086010 membrane depolarization during action potential", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O88427-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23475-1", "uniprot_id": [ { "id": "XRCC6_MOUSE", "url": "https://www.uniprot.org/uniprot/P23475", "type": "external" } ], "mass": 69484.0, "length": 608, "protein_name": "DNA repair protein Ku70", "gene_name": "Xrcc6", "organism": "Mouse", "refseq_name": "DNA repair protein Ku70 isoform 1", "refseq_ac": [ { "id": "NP_034377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034377", "type": "external" } ], "gene_names_uniprotkb": "Xrcc6; G22p1; Ku70", "gene_names_refseq": "70kDa; G22p1; Ku70; Xrcc6", "protein_names_uniprotkb": "DNA repair protein Ku70; 4.2.99.18; 5'-dRP/AP lyase Ku70; 5'-deoxyribose-5-phosphate lyase Ku70; 5.6.2.4; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; Ku autoantigen protein p70 homolog; Ku70; X-ray repair cross-complementing protein 6", "protein_names_refseq": "5'-dRP/AP lyase Ku70; 5'-deoxyribose-5-phosphate lyase Ku70; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein Ku70 isoform 1; DNA repair protein Ku70; DNA repair protein XRCC6; Ku p70; X-ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair cross-complementing protein 6; ku autoantigen protein p70 homolog; thyroid autoantigen 70 kDa", "tax_id": 10090, "disease": "squamous cell carcinoma (Disease Ontology:DOID:1749); basal cell carcinoma (Disease Ontology:DOID:2513)", "pathway": " (mmu:14375); (R-MMU-5693571); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "11471062;12145306;12551933;15023334;1701785;20173027;21750661;30017584;30084848;31219806;32103174;32355287;35545041;38277448;8605992;8661113;9582343", "class_list": "", "function": "DNA-binding protein critical for the DNA damage response, specifically in repairing double-strand breaks (DSBs) via the classical non-homologous end joining (NHEJ) pathway. It forms a heterodimer with XRCC5 (Ku80), creating the Ku70:Ku80 heterodimer (Ku complex), which serves as a DNA end-binding complex. It primarily binds DSBs and recruits essential repair factors, assembling the core long-range NHEJ complex to facilitate the alignment and ligation of broken DNA ends. This pathway ensures the rapid repair of cytotoxic and mutagenic DSBs and contributes to the generation of diversity in T-cell receptors and antibodies through mechanisms such as V(D)J recombination. Likely acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), catalyzing the beta-elimination of the 5'-deoxyribose-5-phosphate at abasic sites near DSBs. This activity cleans the termini of abasic sites, a common form of nucleotide damage, preparing broken ends for ligation. It may also possess 3'-5' DNA helicase activity, although this has not been confirmed in vivo, and its physiological significance remains unclear. Beyond DNA repair, the protein contributes to telomere maintenance (By similarity). It is also implicated in transcriptional regulation, acting as a cofactor for various transcription factors (PubMed:12145306). It plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (By similarity). Can also bind RNAs and recruits PRKDC to a wide range of cellular RNAs, including the U3 small nucleolar RNA, playing a role in the biogenesis of ribosomal RNAs (By similarity). Additionally, it negatively regulates apoptosis by interacting with BAX, sequestering it from the mitochondria, and may possess deubiquitination activity targeting BAX (PubMed:15023334, PubMed:35545041)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Ku70 senses cytosolic DNA and assembles a tumor-suppressive signalosome., [RefSeq, PubMed]; SETD4-mediated KU70 methylation suppresses apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88212;Q3UJL8;Q62027;Q62382;Q62453;Q6GTV8;Q8QZX7", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.14.11.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.51", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.33", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.33", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0051575 5'-deoxyribose-5-phosphate lyase activity;GO:0005524 ATP binding;GO:0003684 damaged DNA binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0070419 nonhomologous end joining complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0097680 double-strand break repair via classical nonhomologous end joining;GO:0006351 DNA-templated transcription;GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P23475-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924Z6-1", "uniprot_id": [ { "id": "XPO6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q924Z6", "type": "external" } ], "mass": 128664.0, "length": 1125, "protein_name": "Exportin-6", "gene_name": "Xpo6", "organism": "Mouse", "refseq_name": "exportin-6 isoform 1", "refseq_ac": [ { "id": "NP_001298072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298072", "type": "external" } ], "gene_names_uniprotkb": "Xpo6; Ranbp20", "gene_names_refseq": "2610005L19Rik; C230091E20Rik; Ranbp20; Xpo6; exp6; mKIAA0370", "protein_names_uniprotkb": "Exportin-6; Exp6; Ran-binding protein 20", "protein_names_refseq": "RAN binding protein 20; exportin-6 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74204)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21750661;22323606;34203471;34428180;38788453", "class_list": "", "function": "Exportin XPO6 upregulation activates the TLR2/MyD88/NF-kappaB signaling by facilitating TLR2 mRNA nuclear export in COPD pulmonary monocytes., [RefSeq, PubMed]; Measurements of nuclear export rates and depletion studies clarified that nuclear export of actin is mediated by exportin 6., [RefSeq, PubMed]; Mediates the nuclear export of actin and profilin-actin complexes in somatic cells., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3K7;Q6PEF3;Q9D0K9", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0005049 nuclear export signal receptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006611 protein export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q924Z6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTU3-1", "uniprot_id": [ { "id": "SCN8A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTU3", "type": "external" } ], "mass": 225141.0, "length": 1978, "protein_name": "Sodium channel protein type 8 subunit alpha", "gene_name": "Scn8a", "organism": "Mouse", "refseq_name": "sodium channel protein type 8 subunit alpha isoform 1", "refseq_ac": [ { "id": "NP_001070967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070967", "type": "external" } ], "gene_names_uniprotkb": "Scn8a; Nbna1", "gene_names_refseq": "C630029C19Rik; NaCh6; Nav1.6; Scn8a; dmu; med; mnd-2; mnd2; nmf2; nmf335; nmf58; nur14; seal", "protein_names_uniprotkb": "Sodium channel protein type 8 subunit alpha; Sodium channel protein type VIII subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.6", "protein_names_refseq": "ataxia 3; sodium channel protein type 8 subunit alpha isoform 1; sodium channel protein type 8 subunit alpha; sodium channel protein type VIII subunit alpha; voltage-gated sodium channel alpha subunit; voltage-gated sodium channel subunit alpha Nav1.6", "tax_id": 10090, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); Dravet syndrome (Disease Ontology:DOID:0080422); developmental and epileptic encephalopathy 13 (Disease Ontology:DOID:0080445); benign familial infantile seizures 5 (Disease Ontology:DOID:0081118); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); epilepsy (Disease Ontology:DOID:1826); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:20273)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11532991;15123669;16014723;19136557;20678086;21750661;23942337;28842554;7670495;8663325;8815882;9295353;9828131", "class_list": "", "function": "Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; More specifically expressed in non-neuronal cells, could play a role in sodium release from intracellular compartments and participate in the control of podosomes formation and macrophages adhesion and movement., [UniProtKB, PubMed]; Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient. Contributes to neuronal excitability by regulating action potential threshold and propagation., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q3TYI3;Q60828;Q60858;Q62449", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0031402 sodium ion binding;GO:0005248 voltage-gated sodium channel activity;GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030054 cell junction", "go_biological_process": "GO:0007626 locomotory behavior;GO:0019228 neuronal action potential;GO:0001508 action potential;GO:0019233 sensory perception of pain;GO:0086010 membrane depolarization during action potential", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9WTU3-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61025-1", "uniprot_id": [ { "id": "CKS1_MOUSE", "url": "https://www.uniprot.org/uniprot/P61025", "type": "external" } ], "mass": 9660.0, "length": 79, "protein_name": "Cyclin-dependent kinases regulatory subunit 1", "gene_name": "Cks1b", "organism": "Mouse", "refseq_name": "cyclin-dependent kinases regulatory subunit 1", "refseq_ac": [ { "id": "NP_058600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058600", "type": "external" } ], "gene_names_uniprotkb": "Cks1b; Cks1; Sid1334", "gene_names_refseq": "2410005G18Rik; 2610005D03Rik; Cks1b; Cks1; sid1334", "protein_names_uniprotkb": "Cyclin-dependent kinases regulatory subunit 1; CKS-1; Sid 1334", "protein_names_refseq": "CKS-1; cyclin-dependent kinase regulatory subunit 1; cyclin-dependent kinases regulatory subunit 1; sid 1334", "tax_id": 10090, "disease": "", "pathway": " (mmu:54124); (R-MMU-187577); (R-MMU-69231)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15513912;21750661;30988159", "class_list": "", "function": "Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data revealed that CKS1 could compensate for CKS2 in mammalian meiosis in vivo but that its expression in the germ line is deleterious for early embryonic development. Publication Status: Online-Only, [RefSeq, PubMed]; FGFR kinase regulates the cell cycle through phosphorylation-dependent release of Cks1 from FGFR substrate 2, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P33551;Q6ZWX7", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042393 histone binding;GO:0043130 ubiquitin binding;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0044772 mitotic cell cycle phase transition;GO:0008283 cell population proliferation;GO:0051301 cell division;GO:0006355 regulation of DNA-templated transcription;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P61025-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06890-1", "uniprot_id": [ { "id": "CLUS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q06890", "type": "external" } ], "mass": 51656.0, "length": 448, "protein_name": "Clusterin", "gene_name": "Clu", "organism": "Mouse", "refseq_name": "clusterin preproprotein", "refseq_ac": [ { "id": "NP_038520", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038520", "type": "external" } ], "gene_names_uniprotkb": "Clu; Apoj; Msgp-2", "gene_names_refseq": "ApoJ; Cli; Clu; D14Ucla3; SP-40; Sgp-2; Sgp2; Sugp-2", "protein_names_uniprotkb": "Clusterin; Apo-J; Apolipoprotein J; Clustrin; SGP-2; Sulfated glycoprotein 2", "protein_names_refseq": "Apolipoprotein J; clusterin preproprotein; clustrin; complement lysis inhibitor; sulfated glycoprotein 2; testosterone repressed prostate message-2", "tax_id": 10090, "disease": "Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); renal fibrosis (Disease Ontology:DOID:0050855); gelatinous drop-like corneal dystrophy (Disease Ontology:DOID:0060449); muscular disease (Disease Ontology:DOID:0080000); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); prostatic hypertrophy (Disease Ontology:DOID:11132); Fuchs' endothelial dystrophy (Disease Ontology:DOID:11555); cicatricial pemphigoid (Disease Ontology:DOID:11656); Kawasaki disease (Disease Ontology:DOID:13378); exfoliation syndrome (Disease Ontology:DOID:13641); breast cancer (Disease Ontology:DOID:1612); atherosclerosis (Disease Ontology:DOID:1936); brain ischemia (Disease Ontology:DOID:2316); prostate adenocarcinoma (Disease Ontology:DOID:2526); invasive ductal carcinoma (Disease Ontology:DOID:3008); acute kidney failure (Disease Ontology:DOID:3021); coronary artery disease (Disease Ontology:DOID:3393); inclusion body myositis (Disease Ontology:DOID:3429); systemic scleroderma (Disease Ontology:DOID:418); conjunctival disease (Disease Ontology:DOID:4251); macular retinal edema (Disease Ontology:DOID:4449); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); nasal cavity adenocarcinoma (Disease Ontology:DOID:4930); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); chronic kidney disease (Disease Ontology:DOID:784); retinal degeneration (Disease Ontology:DOID:8466); mycosis fungoides (Disease Ontology:DOID:8691); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:12759); (R-MMU-114608); (R-MMU-166665); (R-MMU-6803157); (R-MMU-977606)", "pathway_count": 5, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;11067863;11865066;12551933;14741101;16944957;17330941;20571061;21750661;26495903;28011936;30084848;30899004;32152506;34428180;36288343;36852467;37453647;37507081;40997131;8169523;8352774;8354695", "class_list": "", "function": "Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins (By similarity). Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro) (PubMed:14741101). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement: inhibits assembly of the complement membrane attack complex (MAC) by preventing polymerization of C9 pore component of the MAC complex. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity (By similarity). Following stress, promotes apoptosis (PubMed:12551933). Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation. Following ER stress, suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5. When secreted, does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (By similarity). When secreted, acts as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (PubMed:11865066)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; The protein encoded by this gene is a secreted chaperone that can, under some stress conditions, also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. The encoded preproprotein undergoes proteolytic processing to generate a disulfide-linked heterodimeric mature protein comprised of alpha and beta subunits. Mice lacking the encoded protein exhibit increased severity of autoimmune myocarditis, faster progression of the acute inflammation to myocardial scarring and decreased brain injury following neonatal hypoxic-ischemic injury. [provided by RefSeq, Nov 2015]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 34, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0051082 unfolded protein binding;GO:0001540 amyloid-beta binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0002434 immune complex clearance;GO:0001774 microglial cell activation;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "Q06890-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJV9-1", "uniprot_id": [ { "id": "SCN5A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJV9", "type": "external" } ], "mass": 227576.0, "length": 2019, "protein_name": "Sodium channel protein type 5 subunit alpha", "gene_name": "Scn5a", "organism": "Mouse", "refseq_name": "sodium channel protein type 5 subunit alpha isoform 2", "refseq_ac": [ { "id": "NP_001240789", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240789", "type": "external" } ], "gene_names_uniprotkb": "Scn5a", "gene_names_refseq": "Nav1.5c; Nav1.5; Scn5a; SkM1; SkM2; mH1", "protein_names_uniprotkb": "Sodium channel protein type 5 subunit alpha; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein type V subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.5; mH1", "protein_names_refseq": "sodium channel protein cardiac muscle subunit alpha; sodium channel protein type 5 subunit alpha isoform 2; sodium channel protein type 5 subunit alpha; sodium channel protein type V subunit alpha; sodium channel, voltage-gated, type V, alpha polypeptide; voltage-gated sodium channel subunit alpha Nav1.5", "tax_id": 10090, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); familial atrial fibrillation (Disease Ontology:DOID:0050650); generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); Dravet syndrome (Disease Ontology:DOID:0080422); Brugada syndrome 1 (Disease Ontology:DOID:0110218); dilated cardiomyopathy 1E (Disease Ontology:DOID:0110433); long QT syndrome 3 (Disease Ontology:DOID:0110646); progressive familial heart block type IA (Disease Ontology:DOID:0111074); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); sick sinus syndrome (Disease Ontology:DOID:13884); epilepsy (Disease Ontology:DOID:1826); brain ischemia (Disease Ontology:DOID:2316); long QT syndrome (Disease Ontology:DOID:2843); congestive heart failure (Disease Ontology:DOID:6000); sudden infant death syndrome (Disease Ontology:DOID:9007)", "pathway": " (mmu:20271)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11834499;11972032;17124532;21183079;21750661;21817159;23420830;23570977;24129315;26187182;29306897;29932771;30779550;33500550;9412493", "class_list": "", "function": "Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient., [UniProtKB, UniProtKB, UniProtKB]; Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes (By similarity). Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient (By similarity). The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:11834499, PubMed:23420830). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11834499, PubMed:23420830, PubMed:29306897). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (PubMed:29306897)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a, [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 9, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9536, "biomarker_type": "", "glycan_count": 6, "disease_count": 15, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "E9Q1D2;Q3UH91", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0086060 voltage-gated sodium channel activity involved in AV node cell action potential;GO:0086061 voltage-gated sodium channel activity involved in bundle of His cell action potential;GO:0086063 voltage-gated sodium channel activity involved in SA node cell action potential;GO:0005516 calmodulin binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization;GO:0086048 membrane depolarization during bundle of His cell action potential;GO:0003231 cardiac ventricle development;GO:0019228 neuronal action potential;GO:0019233 sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q9JJV9-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1K8-1", "uniprot_id": [ { "id": "YLAT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1K8", "type": "external" } ], "mass": 55677.0, "length": 510, "protein_name": "Y+L amino acid transporter 1", "gene_name": "Slc7a7", "organism": "Mouse", "refseq_name": "Y+L amino acid transporter 1", "refseq_ac": [ { "id": "NP_001240608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240608", "type": "external" } ], "gene_names_uniprotkb": "Slc7a7", "gene_names_refseq": "Slc7a7; my+lat1", "protein_names_uniprotkb": "Y+L amino acid transporter 1; Solute carrier family 7 member 7; Y+LAT1; y(+)L-type amino acid transporter 1; y+LAT-1", "protein_names_refseq": "Y+L amino acid transporter 1; solute carrier family 7 member 7; y(+)L-type amino acid transporter 1; y+LAT-1; y+LAT1", "tax_id": 10090, "disease": "lysinuric protein intolerance (Disease Ontology:DOID:0060439)", "pathway": " (mmu:20540); (R-MMU-210991); (R-MMU-352230)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "15178563;17003226;17242355;17376816;19144319;20173027;21183079;21750661;32504080;35431492;9878049", "class_list": "", "function": "A global Slc7a7 knockout mouse model demonstrates characteristic phenotypes of human lysinuric protein intolerance., [RefSeq, PubMed]; Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine (PubMed:9878049). Also mediates L-arginine transport in non-polarized cells, such as monocytes, and is essential for the correct function of these cells (By similarity). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (By similarity). In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Increased LAT1 expression can be induced by lipid oxidation products relevant to inflammatory responses in atherogenesis. LAT1 mediates lysophosphatidylcholine-enhanced cytokine production by endothelial cells. Erratum:[Arterioscler Thromb Vasc Biol. 2004 Dec;24(12):2425], [RefSeq, PubMed]; Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis., [RefSeq, PubMed]; Selective regulation of SNAT3 and y(+)LAT1 expression may serve a major role in the renal adaptation to acid secretion and thus for systemic acid-base balance., [RefSeq, PubMed]; The Slc7a7(-/-) mouse displayed intrauterine growth restriction, leading to neonatal lethality. After heavy protein ingestion, the surviving adult animals presented metabolic derangement consistent with lysinuric protein intolerance., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9QWS1", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0015174 basic amino acid transmembrane transporter activity;GO:0061459 L-arginine transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:1902495 transmembrane transporter complex;GO:0016020 membrane", "go_biological_process": "GO:0015820 L-leucine transport;GO:0003333 amino acid transmembrane transport;GO:1903826 L-arginine transmembrane transport;GO:0089718 amino acid import across plasma membrane;GO:0006865 amino acid transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Z1K8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P8Y1-1", "uniprot_id": [ { "id": "CAPSL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P8Y1", "type": "external" } ], "mass": 24115.0, "length": 208, "protein_name": "Calcyphosin-like protein", "gene_name": "Capsl", "organism": "Mouse", "refseq_name": "calcyphosin-like protein isoform 1", "refseq_ac": [ { "id": "NP_083617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083617", "type": "external" } ], "gene_names_uniprotkb": "Capsl", "gene_names_refseq": "1700028N11Rik; Capsl", "protein_names_uniprotkb": "Calcyphosin-like protein", "protein_names_refseq": "Calcyphosine; calcyphosin-like protein isoform 1; calcyphosin-like protein", "tax_id": 10090, "disease": "exudative vitreoretinopathy (Disease Ontology:DOID:0050535)", "pathway": " (mmu:75568)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U5X2;Q9D9U6", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0060041 retina development in camera-type eye;GO:0043542 endothelial cell migration;GO:0001935 endothelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P8Y1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z3K2-1", "uniprot_id": [ { "id": "CIP1_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z3K2", "type": "external" } ], "mass": 31386.0, "length": 276, "protein_name": "E3 ubiquitin-protein ligase CCNB1IP1", "gene_name": "Ccnb1ip1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase CCNB1IP1", "refseq_ac": [ { "id": "NP_001104589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104589", "type": "external" } ], "gene_names_uniprotkb": "Ccnb1ip1; Gm288; Hei10; Mei4", "gene_names_refseq": "Ccnb1ip1; Gm288; Hei10; mei4", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase CCNB1IP1; 2.3.2.27; Cyclin-B1-interacting protein 1; RING-type E3 ubiquitin transferase CCNB1IP1", "protein_names_refseq": "E3 ubiquitin-protein ligase CCNB1IP1; RING-type E3 ubiquitin transferase CCNB1IP1", "tax_id": 10090, "disease": "", "pathway": " (mmu:239083)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17784788;20551173;21750661;21779533;24390283;31219806", "class_list": "", "function": "Cloning and characterization of the mei4 ortholog of Hei10 (also known as Gm288 in mouse) demonstrates a novel link between cell cycle regulation and mismatch repair during prophase I., [RefSeq, PubMed]; Mei4 and Rec114, are evolutionarily conserved in most eukaryotes and Mei4(-/-) mice are deficient in meiotic DSB formation, thus showing the functional conservation of Mei4 in mice, [RefSeq, PubMed]; Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over. Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0007286 spermatid development;GO:0016567 protein ubiquitination;GO:0007131 reciprocal meiotic recombination;GO:0001825 blastocyst formation;GO:0051026 chiasma assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "D3Z3K2-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PFX6-1", "uniprot_id": [ { "id": "CAD24_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PFX6", "type": "external" } ], "mass": 84104.0, "length": 781, "protein_name": "Cadherin-24", "gene_name": "Cdh24", "organism": "Mouse", "refseq_name": "cadherin-24 precursor", "refseq_ac": [ { "id": "NP_955764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955764", "type": "external" } ], "gene_names_uniprotkb": "Cdh24", "gene_names_refseq": "1700040A22Rik; Cdh24", "protein_names_uniprotkb": "Cadherin-24", "protein_names_refseq": "EY-cadherin; cadherin-24 precursor; cadherin-24", "tax_id": 10090, "disease": "", "pathway": " (mmu:239096); (R-MMU-418990)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;31219806", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding;GO:0045294 alpha-catenin binding;GO:0070097 delta-catenin binding", "go_cellular_component": "GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0016342 catenin complex;GO:0016020 membrane", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0098609 cell-cell adhesion;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6PFX6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GYP7-1", "uniprot_id": [ { "id": "RGPA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6GYP7", "type": "external" } ], "mass": 229389.0, "length": 2035, "protein_name": "Ral GTPase-activating protein subunit alpha-1", "gene_name": "Ralgapa1", "organism": "Mouse", "refseq_name": "ral GTPase-activating protein subunit alpha-1 isoform 3", "refseq_ac": [ { "id": "NP_001003719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003719", "type": "external" } ], "gene_names_uniprotkb": "Ralgapa1; Garnl1; Kiaa0884; Tulip1", "gene_names_refseq": "2310003F20Rik; 4930400K19Rik; GRIPE; Garnl1; Ralgapa1; Tulip1; mKIAA0884", "protein_names_uniprotkb": "Ral GTPase-activating protein subunit alpha-1; GAP-related-interacting partner to E12; GRIPE; GTPase-activating RapGAP domain-like 1; Tuberin-like protein 1; p240", "protein_names_refseq": "GAP-related interacting partner to E12; GTPase activating RANGAP domain-like 1; GTPase-activating RapGAP domain-like 1; p240; ral GTPase-activating protein alpha subunit 1; ral GTPase-activating protein subunit alpha-1 isoform 3; ral GTPase-activating protein subunit alpha-1; tuberin-like protein 1; tulip 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:56784); (R-MMU-9013407)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;12200424;15498464;17242355;19144319;21183079;21750661;22872234;31219806;34428180;35820727;35879328", "class_list": "", "function": "Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB (By similarity). May interact with the HLH region of TCF3/isoform E12., [UniProtKB]; Interacts with transcription factor E12 in developing forebrain, [RefSeq, PubMed]; The RalGAPalpha1-RalA signal module protects cardiac function through regulating calcium homeostasis. Erratum:[Nat Commun. 2022 Oct 10;13(1):5981. doi: 10.1038/s41467-022-33574-5. PMID: 36216830] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6GYP6;Q6ZQ28;Q8BNJ5;Q8C9G8;Q8CIW4;Q9JMC4", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:0090630 activation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q6GYP7-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHG2-1", "uniprot_id": [ { "id": "RCAN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHG2", "type": "external" } ], "mass": 22025.0, "length": 197, "protein_name": "Calcipressin-2", "gene_name": "Rcan2", "organism": "Mouse", "refseq_name": "calcipressin-2 isoform 2", "refseq_ac": [ { "id": "NP_001273583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273583", "type": "external" } ], "gene_names_uniprotkb": "Rcan2; Dscr1l1; Zaki4", "gene_names_refseq": "Csp2; Dscr1l1; MCIP2; Rcan2; ZAKI-4", "protein_names_uniprotkb": "Calcipressin-2; Calcineurin inhibitory protein ZAKI-4; Down syndrome candidate region 1-like protein 1; MCIP2; Myocyte-enriched calcineurin-interacting protein 2; Regulator of calcineurin 2", "protein_names_refseq": "Down syndrome critical region gene 1-like 1; calcineurin inhibitory protein ZAKI-4; calcipressin-2 isoform 2; calcipressin-2; down syndrome candidate region 1-like protein 1; myocyte-enriched calcineurin interactin protein 2; myocyte-enriched calcineurin-interacting protein 2", "tax_id": 10090, "disease": "Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (mmu:53901)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10722714;11080588;21183079;21750661;28624805;34146582;34348766;36267816", "class_list": "", "function": "A novel transcriptional complex on the VE-cadherin promoter regulated the downregulation of VE-cadherin in the Down Syndrome Candidate Region 1 isoform 1L-mediated angiogenesis., [RefSeq, PubMed]; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; NUAK2 and RCan2 participate in the p53 mutant pro-tumorigenic network. Publication Status: Online-Only, [RefSeq, PubMed]; Our results indicate that Rcan2 and estradiol might regulate body weight through different mechanisms in female mice. Rcan2 increases food intake and promotes weight gain, while estradiol increases energy expenditure possibly by regulating physical activity., [RefSeq, PubMed]; The Overexpression of miR-377 Aggravates Sepsis-Induced Myocardial Hypertrophy by Binding to Rcan2 and Mediating CaN Activity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VIP5", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0007219 Notch signaling pathway;GO:0019722 calcium-mediated signaling;GO:0007614 short-term memory;GO:0031987 locomotion involved in locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JHG2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49935-1", "uniprot_id": [ { "id": "CATH_MOUSE", "url": "https://www.uniprot.org/uniprot/P49935", "type": "external" } ], "mass": 37170.0, "length": 333, "protein_name": "Pro-cathepsin H", "gene_name": "Ctsh", "organism": "Mouse", "refseq_name": "pro-cathepsin H isoform 2", "refseq_ac": [ { "id": "NP_001299578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299578", "type": "external" } ], "gene_names_uniprotkb": "Ctsh", "gene_names_refseq": "Ctsh", "protein_names_uniprotkb": "Pro-cathepsin H; Cathepsin B3; Cathepsin BA", "protein_names_refseq": "Cat H; cathepsin B3; cathepsin BA; pro-cathepsin H isoform 2; pro-cathepsin H", "tax_id": 10090, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); Huntington's disease (Disease Ontology:DOID:12858); transitional cell carcinoma (Disease Ontology:DOID:2671); glioblastoma (Disease Ontology:DOID:3068)", "pathway": " (mmu:13036); (R-MMU-2132295); (R-MMU-5683826); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10395917;21750661;23830514;25428506;26740625;29470604;31599954;34376208;34428180;7722423", "class_list": "", "function": "CatH deficiency impaired toll-like receptor 3-mediated activation of interferon regulatory factor 3 and consequent secretion of IFN-beta, [RefSeq, PubMed]; Cathepsin H deficiency decreases hypoxia-ischemia-induced hippocampal atrophy in neonatal mice through attenuated TLR3/IFN-beta signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Important for the overall degradation of proteins in lysosomes., [UniProtKB]; This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin H mini, heavy, and light chains. In rat and human, these three chains can associate to form the mature enzyme, which has both aminopeptidase and endopeptidase activities. Homozygous knockout mice for this gene exhibit impaired lung surfactant processing and reduced tumorigenesis in a pancreatic cancer model. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UCD6", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0070324 thyroid hormone binding", "go_cellular_component": "GO:0001520 outer dense fiber;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005764 lysosome;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006508 proteolysis;GO:0006955 immune response;GO:0007283 spermatogenesis;GO:0010628 positive regulation of gene expression;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P49935-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V0E1-1", "uniprot_id": [ { "id": "S31G1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V0E1", "type": "external" } ], "mass": 130387.0, "length": 1183, "protein_name": "Spermatogenesis-associated protein 31G1", "gene_name": "Spata31g1", "organism": "Mouse", "refseq_name": "spermatogenesis-associated protein 31G1", "refseq_ac": [ { "id": "NP_080364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080364", "type": "external" } ], "gene_names_uniprotkb": "Spata31g1; 1700022I11Rik", "gene_names_refseq": "1700022I11Rik; Spata31g1", "protein_names_uniprotkb": "Spermatogenesis-associated protein 31G1", "protein_names_refseq": "spermatogenesis-associated protein 31G1; uncharacterized protein C9orf131 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67317)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;36871790", "class_list": "", "function": "C9orf131 and C10orf120 are not essential for male fertility in humans or mice., [RefSeq, PubMed]; Dispensable for normal development and fertility., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AG32;Q9CVP8;Q9CVW7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3V0E1-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06684-1", "uniprot_id": [ { "id": "CO5_MOUSE", "url": "https://www.uniprot.org/uniprot/P06684", "type": "external" } ], "mass": 188878.0, "length": 1680, "protein_name": "Complement C5", "gene_name": "C5; Hc", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "C5; Hc; Hc", "gene_names_refseq": "", "protein_names_uniprotkb": "Complement C5; Complement C5 alpha' chain; Hemolytic complement", "protein_names_refseq": "", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); paroxysmal nocturnal hemoglobinuria (Disease Ontology:DOID:0060284); adult respiratory distress syndrome (Disease Ontology:DOID:11394); factor VIII deficiency (Disease Ontology:DOID:12134); neutropenia (Disease Ontology:DOID:1227); cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); brain edema (Disease Ontology:DOID:4724); liver cirrhosis (Disease Ontology:DOID:5082); pneumonia (Disease Ontology:DOID:552); complement component 5 deficiency (Disease Ontology:DOID:8158)", "pathway": " (mmu:15139); (R-MMU-166665); (R-MMU-174577); (R-MMU-375276); (R-MMU-418594); (R-MMU-977606)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;16944957;1711041;17322886;17330941;21750661;2303408;2436653;26495903;26740625;31219806;34428180;35820727;37507081", "class_list": "", "function": "Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. Complement C5b is generated following cleavage by C5 convertase and initiates formation of the MAC complex: C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9. During MAC complex assembly, the C5b6 subcomplex, composed of complement C5b and C6, associates with the outer leaflet of target cell membrane, reducing the energy for membrane bending., [UniProtKB, UniProtKB]; Mediator of local inflammatory process released following cleavage by C5 convertase. Acts by binding to its receptor (C5AR1 or C5AR2), activating G protein-coupled receptor signaling and inducing a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation., [UniProtKB, UniProtKB]; Precursor of the C5a anaphylatoxin and complement C5b components of the complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Activated downstream of classical, alternative, lectin and GZMK complement pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 12, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2AS36", "ec_number_list": [], "go_molecular_function": "GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005579 membrane attack complex;GO:0044218 other organism cell membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0006954 inflammatory response;GO:0045766 positive regulation of angiogenesis;GO:0031640 killing of cells of another organism;GO:0001867 complement activation, lectin pathway;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P06684-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66K08-1", "uniprot_id": [ { "id": "CILP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q66K08", "type": "external" } ], "mass": 132334.0, "length": 1184, "protein_name": "Cartilage intermediate layer protein 1", "gene_name": "Cilp", "organism": "Mouse", "refseq_name": "cartilage intermediate layer protein 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_775561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775561", "type": "external" } ], "gene_names_uniprotkb": "Cilp", "gene_names_refseq": "9830114D16; C130036G17Rik; CILP-1; Cilp", "protein_names_uniprotkb": "Cartilage intermediate layer protein 1; CILP-1", "protein_names_refseq": "cartilage intermediate layer protein 1 isoform 1 precursor; cartilage intermediate layer protein 1", "tax_id": 10090, "disease": "osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (mmu:214425); (R-MMU-2404192)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "19224205;20173027;21750661;21880736;24631904;26495903;29438665;30084848;31209405;34428180;34610755", "class_list": "", "function": "CILP-1 is a novel extracellular matrix protein possessing anti-fibrotic ability in pressure overload-induced fibrotic remodeling., [RefSeq, PubMed]; Matricellular Protein Cilp1 Promotes Myocardial Fibrosis in Response to Myocardial Infarction., [RefSeq, PubMed]; Overexpression of CILP in the nucleus pulposus cells promotes disc degeneration, indicating that CILP plays a direct role in the pathogenesis of lumbar disc disease., [RefSeq, PubMed]; Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSS0;Q7TSS1;Q8BV01", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway;GO:0060392 negative regulation of SMAD protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q66K08-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q504P2-1", "uniprot_id": [ { "id": "CL12A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q504P2", "type": "external" } ], "mass": 30757.0, "length": 267, "protein_name": "C-type lectin domain family 12 member A", "gene_name": "Clec12a", "organism": "Mouse", "refseq_name": "C-type lectin domain family 12 member A", "refseq_ac": [ { "id": "NP_808354", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808354", "type": "external" } ], "gene_names_uniprotkb": "Clec12a; Micl; klrl1", "gene_names_refseq": "CLL-1; Clec12a; D230024O04; KLRL1; Micl; mKLRL1; mMICL", "protein_names_uniprotkb": "C-type lectin domain family 12 member A; Killer cell C-type lectin-like receptor L1; MICL; Myeloid inhibitory C-type lectin-like receptor; mKLRL1; mMICL", "protein_names_refseq": "C-type lectin domain family 12 member A; C-type lectin-like molecule 1; killer cell C-type lectin-like receptor L1; myeloid inhibitory C-type lectin-like receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:232413); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;14739280;15238421;17609428;18350551;19494282;21750661;24631154;26275430;30787988;31269448;31451663;34428180;34638548;36542980;39143217", "class_list": "glycogene", "function": "Anti-Clec12A mAb alone produced only moderate responses, but these were amplified by coinjecting only small amounts of LPS as a dendritic cell activation agent, [RefSeq, PubMed]; CLL-1 expression is also present on the CD34(+)CD38(-) stem- cell compartment in acute myeloid leukemia, [RefSeq, PubMed]; MMICL recognises an endogenous ligand in a variety of murine tissues, suggesting that the receptor plays a role in homeostasis, [RefSeq, PubMed]; Mycobacterial mycolic acids trigger inhibitory receptor Clec12A to suppress host immune responses., [RefSeq, PubMed]; Myeloid inhibitory C-type lectin receptor that acts as a negative regulator of myeloid cell activation (PubMed:14739280, PubMed:15238421, PubMed:18350551, PubMed:24631154, PubMed:39143217). Myeloid cell inhibition is required to limit proinflammatory pathways and protect against excessive inflammation (PubMed:26275430, PubMed:39143217). Specifically recognizes and binds various structures, such as neutrophil extracellular traps (NETs) or monosodium urate crystals (PubMed:39143217). Also acts as a pattern-recognition receptor for pathogen-associated molecules, such as plasmodium hemozoin or mycobacterial micolic acid (PubMed:31269448, PubMed:36542980). Ligand-binding induces phosphorylation of its ITIM motif, followed by recruitment of tyrosine-protein phosphatases PTPN6 and PTPN11, which counteract tyrosine-protein kinase SYK, thereby preventing myeloid cell activation (PubMed:18350551, PubMed:24631154, PubMed:39143217). Acts as a pattern-recognition receptor for NETs in neutrophils: specifically recognizes DNA in NETs, leading to inhibit neutrophil activation and limit further NET formation (PubMed:39143217). This regulation is essential for controlling key neutrophil responses and limit NET-mediated inflammatory conditions (PubMed:39143217). Also recognizes dead cells by acting as a receptor for monosodium urate crystals, leading to down-regulate neutrophil activation (PubMed:24631154). Binding to monosodium urate crystals also promotes the type I interferon response (PubMed:31451663). Acts as an inhibitor of natural killer (NK) cell cytotoxicity (By similarity). Also acts as an inhibitor of dendritic cell maturation in an IL10-dependent manner (PubMed:30787988)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Recognition and control of neutrophil extracellular trap formation by MICL., [RefSeq, PubMed]; Study observed that the uric acid crystal receptor Clec12A functions as a positive modulator of the IFN-I response, which amplifies nucleic acid-sensing pattern recognition receptors signals through the TBK1-IRF3 axis. Clec12a-/- mice exhibit increased susceptibility to acute lymphocytic choriomeningitis virus (LCMV) infection and improved virus clearance during chronic LCMV infection in vivo., [RefSeq, PubMed]; The molecular cloning, tissue distribution, and functional characterization of a novel NK cell receptor, KLRL1, from human and mouse dendritic cells [KLRL1], [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BN96", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0030246 carbohydrate binding;GO:0019903 protein phosphatase binding;GO:0038187 pattern recognition receptor activity;GO:0030545 signaling receptor regulator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007165 signal transduction;GO:0050728 negative regulation of inflammatory response;GO:0050776 regulation of immune response;GO:0050777 negative regulation of immune response;GO:0032481 positive regulation of type I interferon production", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q504P2-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000010001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H584-1", "uniprot_id": [ { "id": "CO6A5_MOUSE", "url": "https://www.uniprot.org/uniprot/A6H584", "type": "external" } ], "mass": 289575.0, "length": 2640, "protein_name": "Collagen alpha-5(VI) chain", "gene_name": "Col6a5", "organism": "Mouse", "refseq_name": "collagen alpha-5(VI) chain precursor", "refseq_ac": [ { "id": "NP_001161395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161395", "type": "external" } ], "gene_names_uniprotkb": "Col6a5; Col29a1; Gm7455", "gene_names_refseq": "Col29a1; Col6a5; EG665033; Gm7455", "protein_names_uniprotkb": "Collagen alpha-5(VI) chain; Collagen alpha-1(XXIX) chain", "protein_names_refseq": "collagen alpha-1(XXIX) chain; collagen alpha-5(VI) chain precursor; collagen alpha-5(VI) chain", "tax_id": 10090, "disease": "", "pathway": " (mmu:665033); (R-MMU-1442490); (R-MMU-1650814); (R-MMU-186797); (R-MMU-2022090); (R-MMU-216083); (R-MMU-3000178); (R-MMU-419037); (R-MMU-8948216)", "pathway_count": 9, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;18276594;18400749;21477648;21750661;22872234;30084848;30779550;31599954;34418053;34428180;35820727;38523187", "class_list": "", "function": "Analysis of collagen VI chains alpha4, alpha5, and alpha6with high homology to the alpha3 chain, [RefSeq, PubMed]; Collagen VI acts as a cell-binding protein., [UniProtKB, UniProtKB, UniProtKB]; Discovery of three additional collagen VI chains doubles the collagen VI family and adds a layer of complexity to collagen VI assembly and function in the extracellular matrix, [RefSeq, PubMed]; The COL6A5-p.Glu2272* mutation induces chronic itch in mice., [RefSeq, PubMed]; The collagen VI alpha 5 chain is present in perimysium and at the neuromuscular junctions in skeletal muscle, skin, kidney glomerulus, interfollicular stroma in ovary and in the tunica albuginea of testis, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "A6H585;A6H586;E9Q1B5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0005589 collagen type VI trimer", "go_biological_process": "GO:0007155 cell adhesion;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "A6H584-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AX52-1", "uniprot_id": [ { "id": "CO6A4_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AX52", "type": "external" } ], "mass": 250798.0, "length": 2309, "protein_name": "Collagen alpha-4(VI) chain", "gene_name": "Col6a4", "organism": "Mouse", "refseq_name": "collagen alpha-4(VI) chain precursor", "refseq_ac": [ { "id": "NP_081039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039", "type": "external" } ], "gene_names_uniprotkb": "Col6a4; Dvwa", "gene_names_refseq": "1110001D15Rik; Col6a4; Dvwa; EG235580; Vwa6", "protein_names_uniprotkb": "Collagen alpha-4(VI) chain", "protein_names_refseq": "collagen alpha-4(VI) chain precursor; collagen alpha-4(VI) chain; double von Willebrand factor A domains; dual von Willebrand factor A domains", "tax_id": 10090, "disease": "", "pathway": " (mmu:68553)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "18276594;18400749;21057832;21477648;21750661;25428506;30084848;31219806;34428180;35820727", "class_list": "", "function": "Analysis of collagen VI chains alpha4, alpha5, and alpha6with high homology to the alpha3 chain, [RefSeq, PubMed]; Collagen VI acts as a cell-binding protein., [UniProtKB]; DVWA is evolutionally very unique, which, together with its specific expression in articular cartilage, suggests its specific role in human cartilage metabolism., [RefSeq, PubMed]; Discovery of three additional collagen VI chains doubles the collagen VI family and adds a layer of complexity to collagen VI assembly and function in the extracellular matrix, [RefSeq, PubMed]; The collagen VI alpha 4 chain is strongly expressed in the intestinal smooth muscle, surrounding the follicles in ovary, and in testis, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2AX53;A2AX54;A9CR35", "ec_number_list": [], "go_molecular_function": "GO:0005518 collagen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0032991 protein-containing complex;GO:0005589 collagen type VI trimer", "go_biological_process": "GO:0007155 cell adhesion;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A2AX52-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DFV1-1", "uniprot_id": [ { "id": "CNDG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6DFV1", "type": "external" } ], "mass": 130894.0, "length": 1138, "protein_name": "Condensin-2 complex subunit G2", "gene_name": "Ncapg2", "organism": "Mouse", "refseq_name": "condensin-2 complex subunit G2", "refseq_ac": [ { "id": "NP_598523", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598523", "type": "external" } ], "gene_names_uniprotkb": "Ncapg2; Luzp5; Mtb", "gene_names_refseq": "5830426I05Rik; CAP-G2; Luzp5; Mtb; Ncapg2; mCAP-G2", "protein_names_uniprotkb": "Condensin-2 complex subunit G2; CAP-G2; Chromosome-associated protein G2; Leucine zipper protein 5; More than blood protein; Non-SMC condensin II complex subunit G2", "protein_names_refseq": "chromosome-associated protein G2; condensin-2 complex subunit G2; leucine zipper protein 5; more than blood protein", "tax_id": 10090, "disease": "autosomal recessive disease (Disease Ontology:DOID:0050737)", "pathway": " (mmu:76044); (R-MMU-2299718)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "14729962;16673016;21750661;28528544;30059200;30084848;31219806;34203471;34428180;34887587", "class_list": "", "function": "Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. Is required for early embryonic development and is essential for viability and expansion of the inner cell mass (ICM) of the implanting blastocyst., [UniProtKB, PubMed]; The condensin II subunit MTB/mCAP-G2 plays a novel function during erythropoiesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QP71;Q6SLL0;Q922D1", "ec_number_list": [], "go_molecular_function": "GO:0043425 bHLH transcription factor binding;GO:0140117 histone H4K20me1 reader activity", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0000796 condensin complex", "go_biological_process": "GO:1905820 positive regulation of chromosome separation;GO:0051984 positive regulation of chromosome segregation;GO:0051301 cell division;GO:0021987 cerebral cortex development;GO:0007076 mitotic chromosome condensation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6DFV1-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AGT5-1", "uniprot_id": [ { "id": "CKAP5_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AGT5", "type": "external" } ], "mass": 225635.0, "length": 2032, "protein_name": "Cytoskeleton-associated protein 5", "gene_name": "Ckap5", "organism": "Mouse", "refseq_name": "cytoskeleton-associated protein 5 isoform 2", "refseq_ac": [ { "id": "NP_083713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083713", "type": "external" } ], "gene_names_uniprotkb": "Ckap5", "gene_names_refseq": "3110043H24Rik; 4930432B04Rik; Ckap5; D730027C18Rik; mKIAA0097", "protein_names_uniprotkb": "Cytoskeleton-associated protein 5", "protein_names_refseq": "cytoskeleton-associated protein 5 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:75786); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-5663220); (R-MMU-68877); (R-MMU-8854518); (R-MMU-9648025)", "pathway_count": 15, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;19224205;20173027;21183079;21646404;21750661;22645316;23077057;25428506;25428507;28177917;28528544;30016717;30084848;30779550;31219806;34428180;37507081;37828378;38413710;40885482", "class_list": "", "function": "Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Ch-TOG promotes axonal development and is expressed in brain throughout development., [RefSeq, PubMed]; Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Our results demonstrate that CKAP5 is important in oocyte maturation and early embryo development, and CKAP5 might work together with CLTC in mouse oocyte maturation, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A0PJ77;A2AGT6;B2RRC4;Q0VGR0;Q3TML9;Q3UDY6;Q4VAE7;Q9CUN0", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0043021 ribonucleoprotein complex binding;GO:0051010 microtubule plus-end binding;GO:0061863 microtubule plus end polymerase", "go_cellular_component": "GO:0000922 spindle pole;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0046959 habituation;GO:0032289 central nervous system myelin formation;GO:0010609 mRNA localization resulting in post-transcriptional regulation of gene expression;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "A2AGT5-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88507-1", "uniprot_id": [ { "id": "CNTFR_MOUSE", "url": "https://www.uniprot.org/uniprot/O88507", "type": "external" } ], "mass": 40801.0, "length": 372, "protein_name": "Ciliary neurotrophic factor receptor subunit alpha", "gene_name": "Cntfr", "organism": "Mouse", "refseq_name": "ciliary neurotrophic factor receptor subunit alpha preproprotein", "refseq_ac": [ { "id": "NP_001129528", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129528", "type": "external" } ], "gene_names_uniprotkb": "Cntfr", "gene_names_refseq": "Cntfralpha; Cntfr", "protein_names_uniprotkb": "Ciliary neurotrophic factor receptor subunit alpha; CNTF receptor subunit alpha; CNTFR-alpha", "protein_names_refseq": "CNTF receptor subunit alpha; ciliary neurotrophic factor receptor subunit alpha preproprotein; ciliary neurotrophic factor receptor subunit alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:12804); (R-MMU-6788467)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;19349973;21750661;30554447;30899004;31932351;33300544", "class_list": "", "function": "Functions either as a membrane-anchored non-signaling receptor via a GPI anchor or, after proteolytic release, as a soluble ligand-binding chaperone, and mediates signaling of CNTF-related cytokines, including ciliary neurotrophic factor (CNTF), cardiotrophin-like cytokine factor 1 (CLCF1), and the heterodimeric cytokine formed by CLCF1 and the cytokine receptor-like factor 1 (CRLF1). Involved namely in cell survival of motor neurons and regulation of oligodendrocyte progenitor proliferation. Functions within the ciliary neurotrophic factor receptor (CNTFR) complex as a membrane-anchored non-signaling receptor subunit associated with two other signaling receptor subunits IL6ST/gp130 and LIFR. Alternatively functions as a soluble ligand-binding chaperone that binds ligand in the extracellular space, forming a cytokine complex which is delivered to the IL6ST/gp130 and LIFR signaling receptor subunits. Mechanistically, ligand binding to the CNTFR induces dimerization of the IL6ST/gp130 and LIFR (or IL27RA/WSX1 in the case of MT-RNR2/humanin), which activate JAK tyrosine kinases (JAK1 or JAK2 and to lesser extent TYK2) bound to their intracellular domains. These kinases subsequently phosphorylate IL6ST/gp130 and LIFR (or IL27RA/WSX1). The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activators of transcription (STAT3 and to lesser extent STAT1)., [UniProtKB, UniProtKB]; The present data add to the evidence suggesting that enhancing muscle CNTFRalpha expression may promote motor neuron regeneration in trauma and disease., [RefSeq, PubMed]; These studies uncover new physiological roles for GDE3 in gliogenesis and identify GDE3 as a key regulator of CNTF-dependent regulation of oligodendrocyte precursor proliferation through release of CNTFRalpha. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes the alpha subunit of the ciliary neurotrophic factor (CNTF) receptor that triggers the assembly of a trimolecular complex upon binding to CNTF, and initiate a downstream signaling process. The encoded preproprotein undergoes proteolytic processing to generate a glycosylphosphatidylinositol-linked cell surface protein. Mice lacking the encoded protein die shortly after birth and exhibit a reduction of motoneuron number at birth. The transgenic disruption of this gene specifically in the skeletal muscle followed by a peripheral nerve lesion impairs motor neuron axonal regeneration across the lesion site. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q80T01", "ec_number_list": [], "go_molecular_function": "GO:0004897 ciliary neurotrophic factor receptor activity;GO:0004921 interleukin-11 receptor activity;GO:0019970 interleukin-11 binding;GO:0005102 signaling receptor binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0070110 ciliary neurotrophic factor receptor complex;GO:0005615 extracellular space;GO:0009897 external side of plasma membrane;GO:0016324 apical plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0003360 brainstem development;GO:0060538 skeletal muscle organ development;GO:0070120 ciliary neurotrophic factor-mediated signaling pathway;GO:0070446 negative regulation of oligodendrocyte progenitor proliferation;GO:0001967 suckling behavior", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "O88507-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06138-1", "uniprot_id": [ { "id": "CAB39_MOUSE", "url": "https://www.uniprot.org/uniprot/Q06138", "type": "external" } ], "mass": 39843.0, "length": 341, "protein_name": "Calcium-binding protein 39", "gene_name": "Cab39", "organism": "Mouse", "refseq_name": "calcium-binding protein 39 isoform 1", "refseq_ac": [ { "id": "NP_598542", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598542", "type": "external" } ], "gene_names_uniprotkb": "Cab39; Mo25", "gene_names_refseq": "Cab39; MO25alpha; MO25", "protein_names_uniprotkb": "Calcium-binding protein 39; MO25alpha; Protein Mo25", "protein_names_refseq": "calcium binding protein, 39 kDa; calcium-binding protein 39 isoform 1", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); hepatocellular carcinoma (Disease Ontology:DOID:684); hyperthyroidism (Disease Ontology:DOID:7998)", "pathway": " (mmu:12283); (R-MMU-380972); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "21750661;21903876;22844503;24811174;29269522;31219806;34428180;35412939;8418809", "class_list": "", "function": "Cab39 differentially interacts with WNK4 and SPAK/OSR1 to switch the classic two kinase cascade into a signal kinase transduction, [RefSeq, PubMed]; Calcium-binding protein 39 overexpression promotes macrophages from 'M1' into 'M2' phenotype and improves chondrocyte damage in osteoarthritis by activating the AMP-activated protein kinase/sirtuin 1 axis., [RefSeq, PubMed]; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Elevated miR-195 targets the LKB1/AMPK signaling axis in hypertrophic cardiomyopathy, [RefSeq, PubMed]; MiR-144/451 facilitates recovery from acute anemia by repressing Cab39/AMPK/mTOR, [RefSeq, PubMed]; Quantitative PCR revealed significantly reduced LKB1, MO25alpha, and STRADbeta mRNA in LKB1(-/-) muscle. These findings demonstrate that the LKB1-MO25-STRAD complex is the principal AMPKK in skeletal muscle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VDZ8", "ec_number_list": [], "go_molecular_function": "GO:0030295 protein kinase activator activity;GO:0005509 calcium ion binding;GO:0019900 kinase binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0120283 protein serine/threonine kinase binding", "go_cellular_component": "GO:1902554 serine/threonine protein kinase complex;GO:0005737 cytoplasm;GO:0030018 Z disc;GO:0032991 protein-containing complex", "go_biological_process": "GO:0071476 cellular hypotonic response;GO:1901380 negative regulation of potassium ion transmembrane transport;GO:0007165 signal transduction;GO:0035556 intracellular signal transduction;GO:0032147 activation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q06138-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02788-1", "uniprot_id": [ { "id": "CO6A2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q02788", "type": "external" } ], "mass": 110334.0, "length": 1034, "protein_name": "Collagen alpha-2(VI) chain", "gene_name": "Col6a2", "organism": "Mouse", "refseq_name": "collagen alpha-2(VI) chain isoform 2 precursor", "refseq_ac": [ { "id": "NP_001334136", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334136", "type": "external" } ], "gene_names_uniprotkb": "Col6a2", "gene_names_refseq": "Col6a-2; Col6a2", "protein_names_uniprotkb": "Collagen alpha-2(VI) chain", "protein_names_refseq": "collagen alpha-2(VI) chain isoform 2 precursor; collagen alpha-2(VI) chain; procollagen, type VI, alpha 2", "tax_id": 10090, "disease": "Ullrich congenital muscular dystrophy 1B (Disease Ontology:DOID:0060942); Bethlem myopathy 1A (Disease Ontology:DOID:0061198); Bethlem myopathy 1B (Disease Ontology:DOID:0061199); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:12834); (R-MMU-1442490); (R-MMU-1650814); (R-MMU-186797); (R-MMU-2022090); (R-MMU-216083); (R-MMU-3000178); (R-MMU-419037); (R-MMU-8948216)", "pathway_count": 9, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;1709252;21750661;25428506;30084848;30779550;30899004;31219806;31599954;34428180;35820727;37507081;37828378;8380980;8489506", "class_list": "", "function": "Collagen VI acts as a cell-binding protein., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 4, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q05505;Q8C972;Q8K229", "ec_number_list": [], "go_molecular_function": "GO:0005518 collagen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0042383 sarcolemma", "go_biological_process": "GO:0007155 cell adhesion;GO:0051402 neuron apoptotic process;GO:0009411 response to UV;GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q02788-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z7H8-1", "uniprot_id": [ { "id": "CILP2_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z7H8", "type": "external" } ], "mass": 125934.0, "length": 1162, "protein_name": "Cartilage intermediate layer protein 2", "gene_name": "Cilp2", "organism": "Mouse", "refseq_name": "cartilage intermediate layer protein 2 precursor", "refseq_ac": [ { "id": "NP_081094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081094", "type": "external" } ], "gene_names_uniprotkb": "Cilp2", "gene_names_refseq": "1110031K21Rik; CLIP-2; Cilp2", "protein_names_uniprotkb": "Cartilage intermediate layer protein 2", "protein_names_refseq": "cartilage intermediate layer protein 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:68709)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21880736;34887587;38816545", "class_list": "", "function": "CILP2 is a potential biomarker for the prediction and therapeutic target of peritoneal metastases in colorectal cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Cartilage intermediate layer protein 2 (CILP-2) is expressed in articular and meniscal cartilage and down-regulated in experimental osteoarthritis., [RefSeq, PubMed]; May play a role in cartilage scaffolding., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "D3Z7H8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08093-1", "uniprot_id": [ { "id": "CNN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08093", "type": "external" } ], "mass": 33156.0, "length": 305, "protein_name": "Calponin-2", "gene_name": "Cnn2", "organism": "Mouse", "refseq_name": "calponin-2", "refseq_ac": [ { "id": "NP_031751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031751", "type": "external" } ], "gene_names_uniprotkb": "Cnn2", "gene_names_refseq": "Calpo2; Cnn2", "protein_names_uniprotkb": "Calponin-2; Calponin H2, smooth muscle; Neutral calponin", "protein_names_refseq": "calponin H2, smooth muscle; calponin-2; h2-calponin; neutral calponin", "tax_id": 10090, "disease": "", "pathway": " (mmu:12798); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "12388067;21540332;21750661;22645316;23806337;24788674;25153642;25428506;26495903;27802388;28135057;28528544;29187734;30084848;30779550;31599954;34428180;36117313;36963615;37751293;38336796;40021952;8370452", "class_list": "", "function": "Calponin 2 harnesses metabolic reprogramming to determine kidney fibrosis., [RefSeq, PubMed]; Calponin 2 regulates ketogenesis to mitigate acute kidney injury. Publication Status: Online-Only, [RefSeq, PubMed]; Expressed h2-calponin is associated with actin-tropomyosin microfilaments and may regulate cytokinesis by inhibiting the activity of the actin cytoskeleton., [RefSeq, PubMed]; Loss of Calponin 2 causes age-progressive proteinuria in mice., [RefSeq, PubMed]; Loss of Calponin 2 causes premature ovarian insufficiency in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0001725 stress fiber", "go_biological_process": "GO:0007015 actin filament organization;GO:0010628 positive regulation of gene expression;GO:0042127 regulation of cell population proliferation;GO:0030336 negative regulation of cell migration;GO:0031032 actomyosin structure organization", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q08093-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UY34-1", "uniprot_id": [ { "id": "CSTOS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UY34", "type": "external" } ], "mass": 27631.0, "length": 256, "protein_name": "Protein CUSTOS", "gene_name": "2210016L21Rik; Custos", "organism": "Mouse", "refseq_name": "protein CUSTOS", "refseq_ac": [ { "id": "NP_082487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082487", "type": "external" } ], "gene_names_uniprotkb": "2210016L21Rik; Custos", "gene_names_refseq": "2210016L21Rik; Custos", "protein_names_uniprotkb": "Protein CUSTOS", "protein_names_refseq": "protein CUSTOS; uncharacterized protein C12orf43 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:72357)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25153642;28135057", "class_list": "", "function": "Plays a role in the regulation of Wnt signaling pathway during early development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TX98;Q8K0K9;Q9CVB7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005730 nucleolus", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway;GO:0060061 Spemann organizer formation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3UY34-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01149-1", "uniprot_id": [ { "id": "CO1A2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q01149", "type": "external" } ], "mass": 129557.0, "length": 1372, "protein_name": "Collagen alpha-2(I) chain", "gene_name": "Col1a2", "organism": "Mouse", "refseq_name": "collagen alpha-2(I) chain preproprotein", "refseq_ac": [ { "id": "NP_031769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031769", "type": "external" } ], "gene_names_uniprotkb": "Col1a2; Cola2", "gene_names_refseq": "Col1a-2; Col1a2; Cola-2; Cola2; oim", "protein_names_uniprotkb": "Collagen alpha-2(I) chain; Alpha-2 type I collagen", "protein_names_refseq": "alpha-2 type I collagen; collagen COL1A2; collagen alpha-2(I) chain preproprotein; collagen alpha-2(I) chain; procollagen, type I, alpha 2", "tax_id": 10090, "disease": "scoliosis (Disease Ontology:DOID:0060249); Ehlers-Danlos syndrome arthrochalasia type 2 (Disease Ontology:DOID:0080728); Ehlers-Danlos syndrome cardiac valvular type (Disease Ontology:DOID:0080730); osteogenesis imperfecta type 3 (Disease Ontology:DOID:0110339); osteogenesis imperfecta type 4 (Disease Ontology:DOID:0110340); osteogenesis imperfecta type 2 (Disease Ontology:DOID:0110341); intracranial aneurysm (Disease Ontology:DOID:10941); osteoporosis (Disease Ontology:DOID:11476); osteogenesis imperfecta (Disease Ontology:DOID:12347); dilated cardiomyopathy (Disease Ontology:DOID:12930); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); hypothyroidism (Disease Ontology:DOID:1459); pulmonary fibrosis (Disease Ontology:DOID:3770); heart valve disease (Disease Ontology:DOID:4079); ureteral obstruction (Disease Ontology:DOID:5199); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (mmu:12843); (R-MMU-114604); (R-MMU-1650814); (R-MMU-430116); (R-MMU-76009)", "pathway_count": 5, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;1505972;16479539;1748823;20485683;20713358;21750661;26495903;28011936;3039494;31219806;32152506;34428180;36210013;36288343;37828378;8133041", "class_list": "", "function": "This gene encodes the alpha-2 subunit of the fibril-forming type I collagen, the most abundant protein of bone, skin and tendon extracellular matrices. The encoded protein, in association with alpha-1 subunit, forms heterotrimeric type I procollagen that undergoes proteolytic processing during fibril formation. Mice harboring certain mutations in the encoded gene exhibit symptoms of moderate to severe forms of osteogenesis imperfecta. [provided by RefSeq, Dec 2015]., [RefSeq]; Type I collagen is a member of group I collagen (fibrillar forming collagen)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 16, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8CGA5", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix;GO:0005581 collagen trimer;GO:0005584 collagen type I trimer", "go_biological_process": "GO:0085029 extracellular matrix assembly;GO:0008217 regulation of blood pressure;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0001501 skeletal system development;GO:0007266 Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q01149-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M8N0-1", "uniprot_id": [ { "id": "CNRP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5M8N0", "type": "external" } ], "mass": 18612.0, "length": 164, "protein_name": "CB1 cannabinoid receptor-interacting protein 1", "gene_name": "Cnrip1", "organism": "Mouse", "refseq_name": "CB1 cannabinoid receptor-interacting protein 1", "refseq_ac": [ { "id": "NP_084137", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084137", "type": "external" } ], "gene_names_uniprotkb": "Cnrip1", "gene_names_refseq": "1500041B16Rik; 3110054C06Rik; 5330437A18Rik; C2orf32; Cnrip1", "protein_names_uniprotkb": "CB1 cannabinoid receptor-interacting protein 1; CRIP-1", "protein_names_refseq": "CB1 cannabinoid receptor-interacting protein 1; CRIP-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:380686)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17895407;21750661;25446256;25657338;31134094;31327715;34418434;34638827", "class_list": "", "function": "CRIP1a appears to act as a broad negative regulator of CB1 receptor function, [RefSeq, PubMed]; Cannabinoid Receptor Type 1 Regulates Drug Reward Behavior via Glutamate Decarboxylase 67 Transcription. Publication Status: Online-Only, [RefSeq, PubMed]; Cannabinoid receptor interacting protein 1a interacts with myristoylated Galphai N terminus via a unique gapped beta-barrel structure., [RefSeq, PubMed]; Endogenous levels of CRIP1a modulate CB1R-mediated signal transduction by facilitating a Gi/o protein subtype preference for Gi1 and Gi2, accompanied by an overall suppression of G-protein-mediated signaling in neuronal cells., [RefSeq, PubMed]; Pharmacological blockade or genetic deletion of anterior piriform cortex (aPC)-CB1 receptors specifically impaired the retrieval of conditioned odor preference. Interestingly, expression of conditioned odor aversion was unaffected by local CB1 receptor blockade, indicating that the role of aPC endocannabinoid signaling is selective for retrieval of appetitive memory., [RefSeq, PubMed]; Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels., [UniProtKB, UniProtKB, UniProtKB]; These data demonstrate that blocking CB1 receptors leads to upregulation of miR-30e-5p and down regulation of DLL4 in adipose tissue macrophages, which in turn suppress DLL4-Notch signaling-induced polarization of inflammatory Th1 cells and adipocyte energy storage. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAC7;Q3UFR2", "ec_number_list": [], "go_molecular_function": "GO:0031718 type 1 cannabinoid receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043209 myelin sheath", "go_biological_process": "GO:2000272 negative regulation of signaling receptor activity;GO:0010469 regulation of signaling receptor activity;GO:0150036 regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5M8N0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06683-1", "uniprot_id": [ { "id": "CO9_MOUSE", "url": "https://www.uniprot.org/uniprot/P06683", "type": "external" } ], "mass": 62002.0, "length": 548, "protein_name": "Complement component C9", "gene_name": "C9", "organism": "Mouse", "refseq_name": "complement component C9 isoform 1 precursor", "refseq_ac": [ { "id": "NP_038513", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038513", "type": "external" } ], "gene_names_uniprotkb": "C9", "gene_names_refseq": "C9", "protein_names_uniprotkb": "Complement component C9", "protein_names_refseq": "complement component C9 isoform 1 precursor; complement component C9", "tax_id": 10090, "disease": "complement component 9 deficiency (Disease Ontology:DOID:0060303); polycystic kidney disease (Disease Ontology:DOID:0080322); age related macular degeneration 15 (Disease Ontology:DOID:0110027); opiate dependence (Disease Ontology:DOID:2559); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (mmu:12279); (R-MMU-166665); (R-MMU-977606)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;2443347;27444648;30111885;34428180;8437623", "class_list": "", "function": "Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Constitutes the pore-forming subunit of the MAC complex: during MAC assembly, C9 associates with the C5b8 intermediate complex, and polymerizes to complete the pore., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results not only confirm the critical role of C5b-9 in complement-mediated hemolysis and but also highlight the critical role of C5b-9 in inflammasome activation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q91XA7", "ec_number_list": [], "go_molecular_function": "GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:1902495 transmembrane transporter complex;GO:0005579 membrane attack complex;GO:0044218 other organism cell membrane", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0055085 transmembrane transport;GO:0031640 killing of cells of another organism;GO:0050778 positive regulation of immune response;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P06683-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35089-1", "uniprot_id": [ { "id": "CNIH2_MOUSE", "url": "https://www.uniprot.org/uniprot/O35089", "type": "external" } ], "mass": 18931.0, "length": 160, "protein_name": "Protein cornichon homolog 2", "gene_name": "Cnih2", "organism": "Mouse", "refseq_name": "protein cornichon homolog 2 isoform 1", "refseq_ac": [ { "id": "NP_034050", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034050", "type": "external" } ], "gene_names_uniprotkb": "Cnih2; Cnil", "gene_names_refseq": "CNIH-2; Cnih2; Cnil", "protein_names_uniprotkb": "Protein cornichon homolog 2; CNIH-2; Cornichon family AMPA receptor auxiliary protein 2; Cornichon-like protein", "protein_names_refseq": "cornichon-like protein; protein cornichon homolog 2 isoform 1; protein cornichon homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:12794); (R-MMU-204005); (R-MMU-5694530)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10022955;20805473;21172611;21343286;21750661;25428506;30779550;33981040;34079129;36210013", "class_list": "", "function": "Cornichon homolog 2 (CNIH-2) associates with TARP gamma-8 in hippocampus postsynaptic densities; CNIH-2 protein levels are diminished in transmembrane AMPA receptor regulatory protein (TARP) gamma-8 knockout mice., [RefSeq, PubMed]; Gating and modulation of a hetero-octameric AMPA glutamate receptor., [RefSeq, PubMed]; Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors., [UniProtKB, PubMed, PubMed]; This gene encodes a protein that is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. This protein is similar to a Drosophila protein involved in anterior-posterior and dorsal-ventral patterning. Cnih2 conditional knockout mice exhibit reduced AMPA receptor synaptic transmission in the hippocampus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]., [RefSeq]; Transmembrane AMPA receptor regulatory proteins and cornichon-2 allosterically regulate AMPA receptor antagonists and potentiators., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0016247 channel regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0014069 postsynaptic density;GO:0030425 dendrite;GO:0043197 dendritic spine;GO:0043198 dendritic shaft", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:2000310 regulation of NMDA receptor activity;GO:0035249 synaptic transmission, glutamatergic;GO:0016192 vesicle-mediated transport;GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O35089-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35740-1", "uniprot_id": [ { "id": "CITE2_MOUSE", "url": "https://www.uniprot.org/uniprot/O35740", "type": "external" } ], "mass": 28321.0, "length": 269, "protein_name": "Cbp/p300-interacting transactivator 2", "gene_name": "Cited2", "organism": "Mouse", "refseq_name": "cbp/p300-interacting transactivator 2", "refseq_ac": [ { "id": "NP_034958", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034958", "type": "external" } ], "gene_names_uniprotkb": "Cited2; Mrg1; Msg2", "gene_names_refseq": "Cited2; ER154-like; Mrg1; Msg2; p35srj", "protein_names_uniprotkb": "Cbp/p300-interacting transactivator 2; MRG-1; MSG-related protein 1; P35srj", "protein_names_refseq": "MSG-related protein 1; cbp/p300-interacting transactivator 2; melanocyte specific gene 2", "tax_id": 10090, "disease": "mitochondrial complex IV deficiency nuclear type 8 (Disease Ontology:DOID:0070495); atrial heart septal defect 8 (Disease Ontology:DOID:0110113); ventricular septal defect (Disease Ontology:DOID:1657); congenital heart disease (Disease Ontology:DOID:1682); brain ischemia (Disease Ontology:DOID:2316); osteosarcoma (Disease Ontology:DOID:3347); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (mmu:17684); (R-MMU-1234158); (R-MMU-8866907)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10593900;11694877;15051727;15475956;15750185;16619037;17537799;19457926;21224256;21750661;23082118;36358994;36736544;38922923;9434189;9533950", "class_list": "", "function": "Cited2 is a key regulator of placental development and plasticity. Review article, [RefSeq, PubMed]; Gut microbiota-induced microRNA-206-3p increases anxiety-like behaviors by inhibiting expression of Cited2 and STK39., [RefSeq, PubMed]; Pathophysiological Role of Variants of the Promoter Region of CITED2 Gene in Sporadic Tetralogy of Fallot Patients with Cellular Function Verification. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Also acts as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35741;O35742;O35743;O55198;Q6PGA9", "ec_number_list": [], "go_molecular_function": "GO:0050693 LBD domain binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0019904 protein domain specific binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0003156 regulation of animal organ formation;GO:0007530 sex determination;GO:0022409 positive regulation of cell-cell adhesion;GO:0035802 adrenal cortex formation;GO:0060971 embryonic heart tube left/right pattern formation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O35740-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28481-3", "uniprot_id": [ { "id": "CO2A1_MOUSE", "url": "https://www.uniprot.org/uniprot/P28481", "type": "external" } ], "mass": 141973.0, "length": 1487, "protein_name": "Collagen alpha-1(II) chain", "gene_name": "Col2a1", "organism": "Mouse", "refseq_name": "collagen alpha-1(II) chain isoform 2 precursor", "refseq_ac": [ { "id": "NP_001106987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106987", "type": "external" } ], "gene_names_uniprotkb": "Col2a1", "gene_names_refseq": "Col2a-1; Col2a1; Col2a; Col2; Del1; Dmm; Lpk; M100413; Rgsc413; Rgsc856", "protein_names_uniprotkb": "Collagen alpha-1(II) chain; Alpha-1 type II collagen", "protein_names_refseq": "alpha-1 type II collagen; chondrocalcin; collagen alpha-1(II) chain isoform 2 precursor; procollagen, type II, alpha 1", "tax_id": 10090, "disease": "spondyloepimetaphyseal dysplasia (Disease Ontology:DOID:0080027); spondyloepimetaphyseal dysplasia, Strudwick type (Disease Ontology:DOID:0080028); hypochondrogenesis (Disease Ontology:DOID:0080044); Kniest dysplasia (Disease Ontology:DOID:0080045); Stickler syndrome (Disease Ontology:DOID:0080046); achondrogenesis type II (Disease Ontology:DOID:0080056); Stickler syndrome 1 (Disease Ontology:DOID:0080676); multiple epiphyseal dysplasia with myopia and deafness (Disease Ontology:DOID:0111348); Torrance type platyspondylic dysplasia (Disease Ontology:DOID:0111508); spondyloperipheral dysplasia (Disease Ontology:DOID:0112195); spondyloepiphyseal dysplasia Stanescu type (Disease Ontology:DOID:0112281); spondylometaphyseal dysplasia Algerian type (Disease Ontology:DOID:0112296); osteonecrosis (Disease Ontology:DOID:10159); spondyloarthropathy (Disease Ontology:DOID:1123); myopia (Disease Ontology:DOID:11830); Legg-Calve-Perthes disease (Disease Ontology:DOID:14415); hypothyroidism (Disease Ontology:DOID:1459); spondyloepiphyseal dysplasia congenita (Disease Ontology:DOID:14789); osteochondrodysplasia (Disease Ontology:DOID:2256); chondrosarcoma (Disease Ontology:DOID:3371); retinal detachment (Disease Ontology:DOID:5327); eye disease (Disease Ontology:DOID:5614); cleft palate (Disease Ontology:DOID:674); osteoarthritis (Disease Ontology:DOID:8398); chorioretinitis (Disease Ontology:DOID:8886); degenerative disc disease (Disease Ontology:DOID:90)", "pathway": " (mmu:12824); (R-MMU-1442490); (R-MMU-1566977); (R-MMU-1650814); (R-MMU-186797); (R-MMU-2022090); (R-MMU-216083); (R-MMU-3000171); (R-MMU-3000178); (R-MMU-419037); (R-MMU-8874081); (R-MMU-8948216)", "pathway_count": 12, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10605045;12968670;1378019;14734614;16125192;16813664;1797232;1879363;1885613;2054384;27270603;8565294;9418130", "class_list": "", "function": "This gene encodes the alpha-1 subunit of the fibril-forming type II collagen, the major component of cartilage and the vitreous humor of the eye. The encoded preproprotein forms homotrimeric, triple helical procollagen that undergoes proteolytic processing during fibirl formation. Mice harboring certain mutations in this gene exhibit severe chondrodysplasia characterized by short limbs and trunch, craniofacial deformities and cleft palate. A complete lack of the encoded protein in mice results in postnatal lethality. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Dec 2015]., [RefSeq]; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces., [UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 0, "predicted_o_glycosites": 11, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 26, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q61428;Q62031;Q62032;Q62033;Q641K3;Q6LDB1;Q6LDI8;Q6LDI9;Q80VY3;Q80X38;Q8CEF7;Q8K0N6", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0043394 proteoglycan binding;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0005581 collagen trimer", "go_biological_process": "GO:0042472 inner ear morphogenesis;GO:0001894 tissue homeostasis;GO:0007417 central nervous system development;GO:0001501 skeletal system development;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P28481-3", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46737-1", "uniprot_id": [ { "id": "BRCC3_MOUSE", "url": "https://www.uniprot.org/uniprot/P46737", "type": "external" } ], "mass": 33340.0, "length": 291, "protein_name": "Lys-63-specific deubiquitinase BRCC36", "gene_name": "Brcc3", "organism": "Mouse", "refseq_name": "lys-63-specific deubiquitinase BRCC36", "refseq_ac": [ { "id": "NP_001159929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159929", "type": "external" } ], "gene_names_uniprotkb": "Brcc3; Brcc36; C6.1a", "gene_names_refseq": "Brcc3; C6.1A", "protein_names_uniprotkb": "Lys-63-specific deubiquitinase BRCC36; 3.4.19.-; BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 36; BRCA1/BRCA2-containing complex subunit 3; BRISC complex subunit BRCC36", "protein_names_refseq": "6.1A protein; BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 36; BRISC complex subunit BRCC36; lys-63-specific deubiquitinase BRCC36", "tax_id": 10090, "disease": "", "pathway": " (mmu:210766); (R-MMU-5689901); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-69473)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "21750661;23246432;28943315;34180153;39227917;39627609;8247530", "class_list": "", "function": "BRCC36 regulates beta-catenin ubiquitination to alleviate vascular calcification in chronic kidney disease. Publication Status: Online-Only, [RefSeq, PubMed]; Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:23246432, PubMed:34180153). Does not have activity toward 'Lys-48'-linked polyubiquitin chains (By similarity). Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs) (By similarity). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) (By similarity). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (By similarity). Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (By similarity). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (By similarity). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (By similarity). Acts as a regulator of the NLRP3 inflammasome by mediating deubiquitination of NLRP3, leading to NLRP3 inflammasome assembly (PubMed:23246432, PubMed:28943315). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (By similarity). Deubiquitinates HDAC1 and PWWP2B leading to their stabilization (PubMed:34180153)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KGA9;A8Y5K0;Q3UDZ4;Q9D025", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0046872 metal ion binding;GO:0030234 enzyme regulator activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0070552 BRISC complex", "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:0044546 NLRP3 inflammasome complex assembly;GO:0006338 chromatin remodeling;GO:0006508 proteolysis;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P46737-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97766-1", "uniprot_id": [ { "id": "CFC1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97766", "type": "external" } ], "mass": 21792.0, "length": 202, "protein_name": "Cryptic protein", "gene_name": "Cfc1", "organism": "Mouse", "refseq_name": "cryptic protein precursor", "refseq_ac": [ { "id": "NP_031711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031711", "type": "external" } ], "gene_names_uniprotkb": "Cfc1", "gene_names_refseq": "Cfc1; b2b970Clo; cryptic", "protein_names_uniprotkb": "Cryptic protein", "protein_names_refseq": "cripto, FRL-1, cryptic family 1; cryptic protein precursor", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); visceral heterotaxy 2 (Disease Ontology:DOID:0051017); dextro-looped transposition of the great arteries (Disease Ontology:DOID:0060770); right atrial isomerism (Disease Ontology:DOID:0060856); double outlet right ventricle (Disease Ontology:DOID:6406); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (mmu:12627)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10574770;11024280;33730615;9053319", "class_list": "", "function": "Maternal Cripto is critical for proper development of the mouse placenta and the placental vasculature., [RefSeq, PubMed]; Nodal coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q496U5;Q9JIB7", "ec_number_list": [], "go_molecular_function": "GO:0038100 nodal binding;GO:0070697 activin receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0098552 side of membrane", "go_biological_process": "GO:0001889 liver development;GO:0007507 heart development;GO:0007565 female pregnancy;GO:0001568 blood vessel development;GO:0003007 heart morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P97766-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03059-1", "uniprot_id": [ { "id": "CLAT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q03059", "type": "external" } ], "mass": 71853.0, "length": 641, "protein_name": "Choline O-acetyltransferase", "gene_name": "Chat", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Chat", "gene_names_refseq": "", "protein_names_uniprotkb": "Choline O-acetyltransferase; 2.3.1.6; CHOACTase; ChAT; Choline acetylase", "protein_names_refseq": "", "tax_id": 10090, "disease": "congenital myasthenic syndrome 6 (Disease Ontology:DOID:0110671); Alzheimer's disease (Disease Ontology:DOID:10652); depressive disorder (Disease Ontology:DOID:1596); asthma (Disease Ontology:DOID:2841); congenital myasthenic syndrome (Disease Ontology:DOID:3635)", "pathway": " (R-MMU-1483191); (R-MMU-264642)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1400357;2160042;21750661;32069316", "class_list": "", "function": "Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.6", "type": "external" } ], "go_molecular_function": "GO:0004102 choline O-acetyltransferase activity;GO:0033265 choline binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0045202 synapse", "go_biological_process": "GO:0007529 establishment of synaptic specificity at neuromuscular junction;GO:0007274 neuromuscular synaptic transmission;GO:0007613 memory;GO:0016358 dendrite development;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q03059-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04857-1", "uniprot_id": [ { "id": "CO6A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q04857", "type": "external" } ], "mass": 108489.0, "length": 1025, "protein_name": "Collagen alpha-1(VI) chain", "gene_name": "Col6a1", "organism": "Mouse", "refseq_name": "collagen alpha-1(VI) chain precursor", "refseq_ac": [ { "id": "NP_034063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034063", "type": "external" } ], "gene_names_uniprotkb": "Col6a1", "gene_names_refseq": "Col6a-1; Col6a1", "protein_names_uniprotkb": "Collagen alpha-1(VI) chain", "protein_names_refseq": "collagen alpha-1(VI) chain precursor; collagen alpha-1(VI) chain; procollagen, type VI, alpha 1", "tax_id": 10090, "disease": "Ullrich congenital muscular dystrophy (Disease Ontology:DOID:0050558); Bethlem myopathy (Disease Ontology:DOID:0050663); Ullrich congenital muscular dystrophy 1A (Disease Ontology:DOID:0060946); Bethlem myopathy 1A (Disease Ontology:DOID:0061198)", "pathway": " (mmu:12833); (R-MMU-1442490); (R-MMU-1650814); (R-MMU-186797); (R-MMU-2022090); (R-MMU-216083); (R-MMU-3000178); (R-MMU-419037); (R-MMU-8948216)", "pathway_count": 9, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;25428506;25605945;28011936;28135057;29187734;31599954;34428180;35857791;36288343;37272555;37507081;37828378;39927985;8326912;8489506", "class_list": "", "function": "Collagen VI acts as a cell-binding protein., [UniProtKB]; Collagen VI promotes recovery from colitis by inducing lymphangiogenesis and drainage of inflammatory cells., [RefSeq, PubMed]; Lack of COL6/collagen VI causes megakaryocyte dysfunction by impairing autophagy and inducing apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 17, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005518 collagen binding;GO:0048407 platelet-derived growth factor binding", "go_cellular_component": "GO:0097708 intracellular vesicle;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0031012 extracellular matrix", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0060538 skeletal muscle organ development;GO:0010657 muscle cell apoptotic process;GO:0050954 sensory perception of mechanical stimulus;GO:0085029 extracellular matrix assembly", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "Q04857-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07409-1", "uniprot_id": [ { "id": "CNTN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q07409", "type": "external" } ], "mass": 113232.0, "length": 1028, "protein_name": "Contactin-3", "gene_name": "Cntn3", "organism": "Mouse", "refseq_name": "contactin-3 precursor", "refseq_ac": [ { "id": "NP_032805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032805", "type": "external" } ], "gene_names_uniprotkb": "Cntn3; Pang; Pcs", "gene_names_refseq": "Cntn3; Pang", "protein_names_uniprotkb": "Contactin-3; BIG-1; Brain-derived immunoglobulin superfamily protein 1; Plasmacytoma-associated neuronal glycoprotein", "protein_names_refseq": "BIG-1; brain-derived immunoglobulin superfamily protein 1; contactin-3 precursor; plasmacytoma-associated neuronal glycoprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:18488); (R-MMU-163125)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;20133774;27539848;30084848;30779550;30899004;31318883;8108413", "class_list": "", "function": "Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity)., [UniProtKB]; Protein-tyrosine phosphatase receptor type G (RPTPgamma/PTPRG) interacts in vitro with contactin-3-6 (CNTN3-6), a group of glycophosphatidylinositol-anchored cell adhesion molecules involved in the wiring of the nervous system, [RefSeq, PubMed]; These experiments define the regions of direct contact that mediate the binding interaction between APP and CNTN3. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 11, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 11, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 11, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 11, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 13, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "G5E878", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection;GO:0098552 side of membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q07409-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P523-1", "uniprot_id": [ { "id": "CIB3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0P523", "type": "external" } ], "mass": 18668.0, "length": 160, "protein_name": "Calcium and integrin-binding family member 3", "gene_name": "Cib3", "organism": "Mouse", "refseq_name": "calcium and integrin-binding family member 3 isoform 2", "refseq_ac": [ { "id": "NP_001074281", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074281", "type": "external" } ], "gene_names_uniprotkb": "Cib3", "gene_names_refseq": "C730014M21Rik; Cib3; Gm1107; KIP3", "protein_names_uniprotkb": "Calcium and integrin-binding family member 3", "protein_names_refseq": "calcium and integrin-binding family member 3 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:234421)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18989529;21750661;29255404;34089643;37001993", "class_list": "", "function": "Acts as an auxiliary subunit of the sensory mechanoelectrical transduction (MET) channel in hair cells (PubMed:34089643). Plays a role in regulating hair cell MET channel localization and function (PubMed:34089643)., [UniProtKB, PubMed]; CIB2 and CIB3 Regulate Stereocilia Maintenance and Mechanoelectrical Transduction in Mouse Vestibular Hair Cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005509 calcium ion binding", "go_cellular_component": "", "go_biological_process": "GO:0055074 calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q0P523-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32NY4-1", "uniprot_id": [ { "id": "CNNM3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q32NY4", "type": "external" } ], "mass": 76279.0, "length": 713, "protein_name": "Metal transporter CNNM3", "gene_name": "Cnnm3", "organism": "Mouse", "refseq_name": "metal transporter CNNM3 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001034640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034640", "type": "external" } ], "gene_names_uniprotkb": "Cnnm3; Acdp3", "gene_names_refseq": "Acdp3; Clp3; Cnnm3; mACDP3", "protein_names_uniprotkb": "Metal transporter CNNM3; Ancient conserved domain-containing protein 3; Cyclin-M3; mACDP3", "protein_names_refseq": "ancient conserved domain-containing protein 3; metal transporter CNNM3 isoform 2 precursor; metal transporter CNNM3", "tax_id": 10090, "disease": "", "pathway": " (mmu:94218)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14723793;19144319;21183079;22399287;24632616;25428506;39927985", "class_list": "", "function": "Oncogenic PRL-2 controls tumor growth by modulating intracellular magnesium levels through binding with the CNNM3 magnesium transporter., [RefSeq, PubMed]; Probable metal transporter., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A3KML7;Q3UFE5;Q7TSZ4;Q8C342;Q9JIM6", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0010960 magnesium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q32NY4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KNL4-1", "uniprot_id": [ { "id": "CJ053_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3KNL4", "type": "external" } ], "mass": 10386.0, "length": 93, "protein_name": "UPF0728 protein C10orf53 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "UPF0728 protein C10orf53 homolog", "refseq_ac": [ { "id": "NP_001029209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029209", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "1700024G13Rik; C10orf53", "protein_names_uniprotkb": "UPF0728 protein C10orf53 homolog", "protein_names_refseq": "UPF0728 protein C10orf53 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67085)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17971504", "class_list": "", "function": "1700024G13Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3KNL4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TTJ4-1", "uniprot_id": [ { "id": "CH048_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TTJ4", "type": "external" } ], "mass": 33319.0, "length": 293, "protein_name": "Uncharacterized protein C8orf48 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C8orf48 homolog", "refseq_ac": [ { "id": "NP_001034309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034309", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "AI429214", "protein_names_uniprotkb": "Uncharacterized protein C8orf48 homolog", "protein_names_refseq": "uncharacterized protein C8orf48 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:621080)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34418053", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3TTJ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U6N9-1", "uniprot_id": [ { "id": "CH033_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U6N9", "type": "external" } ], "mass": 24465.0, "length": 222, "protein_name": "UPF0488 protein C8orf33 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "UPF0488 protein C8orf33 homolog isoform 1", "refseq_ac": [ { "id": "NP_001334469", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334469", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "1110038F14Rik", "protein_names_uniprotkb": "UPF0488 protein C8orf33 homolog", "protein_names_refseq": "UPF0488 protein C8orf33 homolog isoform 1; UPF0488 protein C8orf33 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:117171)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3URI5;Q9D0Z5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3U6N9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UHX9-1", "uniprot_id": [ { "id": "SPOUT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UHX9", "type": "external" } ], "mass": 42958.0, "length": 385, "protein_name": "28S rRNA (uridine-N(3))-methyltransferase", "gene_name": "Spout1", "organism": "Mouse", "refseq_name": "28S rRNA (uridine-N(3))-methyltransferase", "refseq_ac": [ { "id": "NP_766248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766248", "type": "external" } ], "gene_names_uniprotkb": "Spout1; D2Wsu81e", "gene_names_refseq": "9930028P05; CENP-32; D2Wsu81e; Spout1", "protein_names_uniprotkb": "28S rRNA (uridine-N(3))-methyltransferase; 2.1.1.-; CENP-32; Centromere protein 32; Kinetochore-associated protein; Methyltransferase C9orf114 homolog; SPOUT domain-containing methyltransferase 1", "protein_names_refseq": "28S rRNA (uridine-N(3))-methyltransferase; centromere protein 32; kinetochore-associated protein; putative methyltransferase C9orf114 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:227695)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "34428180;35820727", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase. Specifically methylates the N3 position of a uridine in 28S rRNA. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase, ensuring proper spindle organization. Also involved in chromosome alignment. May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis. Binds specifically to miRNA MIR145 hairpin, regulates MIR145 expression at a postranscriptional level., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQY9", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0008168 methyltransferase activity;GO:0035198 miRNA binding;GO:0070042 rRNA (uridine-N3-)-methyltransferase activity;GO:0008173 RNA methyltransferase activity;GO:1904047 S-adenosyl-L-methionine binding", "go_cellular_component": "GO:0000776 kinetochore;GO:0031616 spindle pole centrosome;GO:0072686 mitotic spindle", "go_biological_process": "GO:0051301 cell division;GO:0010608 post-transcriptional regulation of gene expression;GO:0051661 maintenance of centrosome location;GO:0035196 miRNA processing;GO:0070475 rRNA base methylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UHX9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U901-1", "uniprot_id": [ { "id": "CBPA6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5U901", "type": "external" } ], "mass": 51143.0, "length": 438, "protein_name": "Carboxypeptidase A6", "gene_name": "Cpa6", "organism": "Mouse", "refseq_name": "carboxypeptidase A6 isoform 2", "refseq_ac": [ { "id": "NP_001276426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276426", "type": "external" } ], "gene_names_uniprotkb": "Cpa6", "gene_names_refseq": "9030616D13Rik; Cpa6", "protein_names_uniprotkb": "Carboxypeptidase A6; 3.4.17.-", "protein_names_refseq": "carboxypeptidase A6 isoform 2; metallocarboxypeptidase", "tax_id": 10090, "disease": "familial temporal lobe epilepsy 5 (Disease Ontology:DOID:0060752); familial febrile seizures 11 (Disease Ontology:DOID:0111308)", "pathway": " (mmu:329093)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15950771;18178555;21750661", "class_list": "", "function": "CPA6 may have a role in the regulation of neuropeptides in the extracellular environment within the olfactory bulb and other parts of the brain, [RefSeq, PubMed]; May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensin II. Releases a C-terminal amino acid, with preference for large hydrophobic C-terminal amino acids and shows only very weak activity toward small amino acids and histidine., [UniProtKB]; The distribution of Cpa6 suggests a specific role in a limited number of tissues, and it is possible that this role involves an aspect of cell migration., [RefSeq, PubMed]; This gene encodes a protein that belongs to the metallocarboxypeptidase family of proteins that catalyze the release of a C-terminal amino acid from the target protein. The encoded preproprotein undergoes proteolytic cleavage to yield the mature form which is thought to play a role in cell migration. In humans, this protein regulates neuropeptides in the brain and mutations in this gene are associated with a recessive familial form of febrile seizures and with temporal lobe epilepsy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVD0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5U901-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60649-1", "uniprot_id": [ { "id": "CLPB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60649", "type": "external" } ], "mass": 76004.0, "length": 677, "protein_name": "Mitochondrial disaggregase", "gene_name": "Clpb", "organism": "Mouse", "refseq_name": "mitochondrial disaggregase isoform 1 precursor", "refseq_ac": [ { "id": "NP_033217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033217", "type": "external" } ], "gene_names_uniprotkb": "Clpb; Skd3", "gene_names_refseq": "Clpb; Skd3", "protein_names_uniprotkb": "Mitochondrial disaggregase; 3.6.1.-; Suppressor of potassium transport defect 3", "protein_names_refseq": "ClpB caseinolytic peptidase B homolog; caseinolytic peptidase B protein homolog; mitochondrial disaggregase isoform 1 precursor; mitochondrial disaggregase; suppressor of K+ transport defect 3; suppressor of potassium transport defect 3", "tax_id": 10090, "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590); 3-methylglutaconic aciduria type 7a (Disease Ontology:DOID:0081133); 3-methylglutaconic aciduria type 7b (Disease Ontology:DOID:0081134)", "pathway": " (mmu:20480)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;34428180;7835694", "class_list": "", "function": "Functions as a regulatory ATPase and participates in secretion/protein trafficking process. Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6. Plays a role in granulocyte differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140545 ATP-dependent protein disaggregase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0030851 granulocyte differentiation;GO:0034605 cellular response to heat;GO:0039529 RIG-I signaling pathway;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q60649-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63870-1", "uniprot_id": [ { "id": "CO7A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q63870", "type": "external" } ], "mass": 295232.0, "length": 2944, "protein_name": "Collagen alpha-1(VII) chain", "gene_name": "Col7a1", "organism": "Mouse", "refseq_name": "collagen alpha-1(VII) chain precursor", "refseq_ac": [ { "id": "NP_031764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031764", "type": "external" } ], "gene_names_uniprotkb": "Col7a1", "gene_names_refseq": "Col7a1", "protein_names_uniprotkb": "Collagen alpha-1(VII) chain; LC collagen; Long-chain collagen", "protein_names_refseq": "LC collagen; collagen alpha-1(VII) chain precursor; collagen alpha-1(VII) chain; long-chain collagen; procollagen, type VII, alpha 1", "tax_id": 10090, "disease": "recessive dystrophic epidermolysis bullosa (Disease Ontology:DOID:0060642); nonsyndromic congenital nail disorder 8 (Disease Ontology:DOID:0080086); autosomal dominant dystrophic epidermolysis bullosa (Disease Ontology:DOID:0080224); pretibial dystrophic epidermolysis bullosa (Disease Ontology:DOID:0080988); transient bullous dermolysis of the newborn (Disease Ontology:DOID:0111345); epidermolysis bullosa with congenital localized absence of skin and deformity of nails (Disease Ontology:DOID:0111347); epidermolysis bullosa dystrophica (Disease Ontology:DOID:4959)", "pathway": " (mmu:12836); (R-MMU-1442490); (R-MMU-1566977); (R-MMU-1650814); (R-MMU-204005); (R-MMU-216083); (R-MMU-2214320); (R-MMU-5694530); (R-MMU-8948216)", "pathway_count": 9, "publication_count": 10, "publication_id_list": "10523500;14675198;20173027;25428506;31219806;34428180;35690907;38876908;8325648;8752674", "class_list": "", "function": "Histological and molecular restoration of type VII collagen in Recessive dystrophic epidermolysis bullosa mouse skin by topical injection of keratinocyte-like cells differentiated from human adipose-derived mesenchymal stromal cells., [RefSeq, PubMed]; Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen., [UniProtKB, UniProtKB, PubMed]; Therapeutic base editing and prime editing of COL7A1 mutations in recessive dystrophic epidermolysis bullosa., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 3, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q78EC6", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0042802 identical protein binding;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0030198 extracellular matrix organization;GO:0030199 collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q63870-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DG52-1", "uniprot_id": [ { "id": "CHUR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6DG52", "type": "external" } ], "mass": 12858.0, "length": 112, "protein_name": "Protein Churchill", "gene_name": "Churc1", "organism": "Mouse", "refseq_name": "protein Churchill", "refseq_ac": [ { "id": "NP_996257", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996257", "type": "external" } ], "gene_names_uniprotkb": "Churc1", "gene_names_refseq": "1700030P15Rik; Churc1; My015; chch", "protein_names_uniprotkb": "Protein Churchill", "protein_names_refseq": "protein Churchill", "tax_id": 10090, "disease": "", "pathway": " (mmu:211151)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Transcriptional activator that mediates FGF signaling during neural development (By similarity). Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCP1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007498 mesoderm development;GO:0008543 fibroblast growth factor receptor signaling pathway;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6DG52-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PGK7-1", "uniprot_id": [ { "id": "CHSTA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PGK7", "type": "external" } ], "mass": 42055.0, "length": 356, "protein_name": "Carbohydrate sulfotransferase 10", "gene_name": "Chst10", "organism": "Mouse", "refseq_name": "carbohydrate sulfotransferase 10", "refseq_ac": [ { "id": "NP_001355709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001355709", "type": "external" } ], "gene_names_uniprotkb": "Chst10", "gene_names_refseq": "Chst10; Hnk-1st; ST", "protein_names_uniprotkb": "Carbohydrate sulfotransferase 10; 2.8.2.-; HNK-1 sulfotransferase; HNK-1ST; HNK1ST", "protein_names_refseq": "HNK-1 sulfotransferase; HNK1ST; carbohydrate sulfotransferase 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:98388); (R-MMU-975578); (R-MMU-9939291)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12213450;12358771;16262627;17157030;21750661;23269668", "class_list": "glycan-modifying enzyme;glycogene;glycosyltransferase", "function": "Catalyzes the transfer of sulfate from 3'-phosphoadenylyl sulfate (PAPS) to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure 3-O-sulfo-beta-D-GlcA-(1->3)-beta-D-Gal-(1->4)-D-GlcNAc-R, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis (PubMed:12213450, PubMed:12358771). Sulfates terminal glucuronyl residue of the laminin globular (LG)-domain binding epitope on DAG1/alpha-dystroglycan and prevents further polymerization by LARGE1 glycosyltransferase. Likely defines the chain length of LG epitope, conferring binding specificity to extracellular matrix components (By similarity). Plays a role in down-regulating the steroid hormones. Sulfates glucuronidated estrogens and androgens with an impact in hormone cycle and fertility. Has a preference for glucuronyl moiety at the 3-hydroxyl group of a sterol ring rather than the 17-hydroxyl group, showing high catalytic efficiency for 17beta-estradiol 3-O-(beta-D-glucuronate) and dehydroepiandrosterone 3-O-(beta-D-glucuronate) hormones (By similarity) (PubMed:23269668)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Chst10 likely functions in widespread regulation of steroid hormones in vivo, [RefSeq, PubMed]; These findings reveal alterations in ST-/- mice that differ from EEG abnormalities of mice deficient in the HNK-1 carrier molecule tenascin-R., [RefSeq, PubMed]; This study conclude that in ST-/- mice which show morphological, electrophysiological and behavioural abnormalities, the ECS is reduced and its geometry altered., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKU3;Q8BL08;Q8R2Y5;Q91Y40", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0016232 HNK-1 sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0016051 carbohydrate biosynthetic process;GO:0007612 learning;GO:0008209 androgen metabolic process;GO:0007616 long-term memory", "synthesized_glycan_count": 16, "hit_score": 1.0, "record_id": "Q6PGK7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.11010", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZQK0-1", "uniprot_id": [ { "id": "CNDD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZQK0", "type": "external" } ], "mass": 169432.0, "length": 1506, "protein_name": "Condensin-2 complex subunit D3", "gene_name": "Ncapd3", "organism": "Mouse", "refseq_name": "condensin-2 complex subunit D3 isoform 1", "refseq_ac": [ { "id": "NP_835214", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_835214", "type": "external" } ], "gene_names_uniprotkb": "Ncapd3; Kiaa0056", "gene_names_refseq": "2810487N22Rik; 4632407J06Rik; B130055D15Rik; Ncapd3; mKIAA0056", "protein_names_uniprotkb": "Condensin-2 complex subunit D3; Non-SMC condensin II complex subunit D3", "protein_names_refseq": "Jacobsen syndrome region 2; condensin-2 complex subunit D3 isoform 1; condensin-2 complex subunit D3", "tax_id": 10090, "disease": "primary autosomal recessive microcephaly 22 (Disease Ontology:DOID:0051033)", "pathway": " (mmu:78658); (R-MMU-2299718)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;34428180;36852467", "class_list": "", "function": "Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QPR0;Q9CS21", "ec_number_list": [], "go_molecular_function": "GO:0042393 histone binding;GO:0140117 histone H4K20me1 reader activity", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005654 nucleoplasm;GO:0000793 condensed chromosome;GO:0000776 kinetochore;GO:0000796 condensin complex", "go_biological_process": "GO:1905820 positive regulation of chromosome separation;GO:0051984 positive regulation of chromosome segregation;GO:0051307 meiotic chromosome separation;GO:0051301 cell division;GO:0021987 cerebral cortex development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6ZQK0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSN2-1", "uniprot_id": [ { "id": "CLM4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TSN2", "type": "external" } ], "mass": 25206.0, "length": 228, "protein_name": "CMRF-35-like molecule 4", "gene_name": "Cd300c2", "organism": "Mouse", "refseq_name": "CMRF-35-like molecule 4 precursor", "refseq_ac": [ { "id": "NP_598919", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598919", "type": "external" } ], "gene_names_uniprotkb": "Cd300c2; AF251705; Cd300c; Clm4; Igsf7; Lmir2", "gene_names_refseq": "CLM-4; CLM4; Cd300c2; Cd300c; Cd300d; DIgR1; Igsf7; Lmir2; MAIR-II", "protein_names_uniprotkb": "CMRF-35-like molecule 4; CD300C molecule 2; CLM-4; DIgR1; Dendritic cell-derived Ig-like receptor 1; IgSF7; Immunoglobulin superfamily member 7; Leukocyte mono-Ig-like receptor 2; MAIR-2; MAIR-II; Myeloid-associated immunoglobulin-like receptor 2", "protein_names_refseq": "CLM; CMRF-35-like molecule 4 precursor; CMRF-35-like molecule 4; CMRF35-like molecule; Cd300C antigen; Cd300D antigen; MAIR-2; dendritic cell-derived Ig-like receptor 1; dendritic cell-derived immunoglobulin receptor 1; immunoglobulin superfamily, member 7; leukocyte mono-Ig-like receptor 2; myeloid-associated immunoglobulin-like receptor 2; myeloid-associated immunoglobulin-like receptor II", "tax_id": 10090, "disease": "", "pathway": " (mmu:140497)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11549249;12456026;12874256;12893283;14662855;17202337;21727189;21750661;25134989;31757863;33140535", "class_list": "", "function": "Acts as an activating receptor in mast cells and macrophages., [UniProtKB, PubMed, PubMed, PubMed]; DAP12-coupled MAIR-II negatively regulates B cell-mediated adaptive immune responses., [RefSeq, PubMed]; MAIR-II deficiency ameliorates cardiac remodelling post-myocardial infarction by suppressing TLR9-mediated macrophage activation., [RefSeq, PubMed]; Molecular cloning and characterization of leukocyte mono-immunoglobulin-like receptor1 and 2 derived from mast cells [LMIR1] [LMIR2], [RefSeq, PubMed]; Our findings demonstrate that CD300c2 contributes to BLM-induced inflammatory responses mediated by alveolar macrophages., [RefSeq, PubMed]; Structure and tissue distribution Review article, [RefSeq, PubMed]; Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated inflammatory monocyte migration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TN55;Q8JZM5", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0001819 positive regulation of cytokine production;GO:0002376 immune system process;GO:0045088 regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7TSN2-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80W69-1", "uniprot_id": [ { "id": "CL071_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80W69", "type": "external" } ], "mass": 34755.0, "length": 301, "protein_name": "Uncharacterized protein C12orf71 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C12orf71 homolog isoform 2", "refseq_ac": [ { "id": "NP_001157708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157708", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "1700034J05Rik", "protein_names_uniprotkb": "Uncharacterized protein C12orf71 homolog", "protein_names_refseq": "uncharacterized protein C12orf71 homolog isoform 2; uncharacterized protein C12orf71 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:73344)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C629;Q8CDR6;Q9D9Q1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q80W69-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZQ3-1", "uniprot_id": [ { "id": "CH074_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80ZQ3", "type": "external" } ], "mass": 33958.0, "length": 298, "protein_name": "Uncharacterized protein C8orf74 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C8orf74 homolog", "refseq_ac": [ { "id": "NP_080635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080635", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "4930578I06Rik", "protein_names_uniprotkb": "Uncharacterized protein C8orf74 homolog", "protein_names_refseq": "uncharacterized protein C8orf74 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67750)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CVZ7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q80ZQ3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BG92-1", "uniprot_id": [ { "id": "CLVS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BG92", "type": "external" } ], "mass": 37954.0, "length": 327, "protein_name": "Clavesin-2", "gene_name": "Clvs2", "organism": "Mouse", "refseq_name": "clavesin-2 isoform 1", "refseq_ac": [ { "id": "NP_780657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780657", "type": "external" } ], "gene_names_uniprotkb": "Clvs2; Rlbp1l2", "gene_names_refseq": "A330019N05Rik; Clvs2; Rlbp1l2", "protein_names_uniprotkb": "Clavesin-2; Retinaldehyde-binding protein 1-like 2", "protein_names_refseq": "clavesin-2 isoform 1; retinaldehyde-binding protein 1-like 2; retinaldehyde-binding protein 1-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:215890); (R-MMU-432720)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKA5", "ec_number_list": [], "go_molecular_function": "GO:1902936 phosphatidylinositol bisphosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005768 endosome;GO:0031901 early endosome membrane;GO:0030136 clathrin-coated vesicle;GO:0005802 trans-Golgi network;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007040 lysosome organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BG92-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGN9-1", "uniprot_id": [ { "id": "RDD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGN9", "type": "external" } ], "mass": 15388.0, "length": 141, "protein_name": "Required for drug-induced death protein 1", "gene_name": "", "organism": "Mouse", "refseq_name": "required for drug-induced death protein 1", "refseq_ac": [ { "id": "NP_848807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848807", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "C130074G19Rik", "protein_names_uniprotkb": "Required for drug-induced death protein 1", "protein_names_refseq": "required for drug-induced death protein 1; uncharacterized protein C1orf115 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:226777)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates drug efflux through modulation of ABCB1 localization and activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0097731 9+0 non-motile cilium", "go_biological_process": "GO:2001023 regulation of response to drug", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BGN9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGU2-1", "uniprot_id": [ { "id": "CBLN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGU2", "type": "external" } ], "mass": 24051.0, "length": 224, "protein_name": "Cerebellin-2", "gene_name": "Cbln2", "organism": "Mouse", "refseq_name": "cerebellin-2 precursor", "refseq_ac": [ { "id": "NP_001289285", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289285", "type": "external" } ], "gene_names_uniprotkb": "Cbln2", "gene_names_refseq": "6330593N19Rik; A730004O05; Cbln2", "protein_names_uniprotkb": "Cerebellin-2", "protein_names_refseq": "cerebellin-2 precursor; cerebellin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:12405)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;16930405;17030622;17331201;21410790;22220752;23853053;29691328;29782851;30287486;30899004;33300544;34135511", "class_list": "", "function": "Acts as a synaptic organizer in specific subsets of neurons in the brain (PubMed:21410790, PubMed:29691328). Essential for long-term maintenance but not establishment of excitatory synapses (PubMed:29691328, PubMed:30287486). Functions as part of a trans-synaptic complex by binding to postsynaptic GRID1 and presynaptic neurexins. This interaction helps regulate the activity of NMDA and AMPA receptors at hippocampal synapses without affecting synapse formation. NRXN1B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic NMDAR response. NRXN3B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic AMPAR response (PubMed:34135511)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; That neurons expressing Cblns 1, 2, and 4 tend to occupy different laminar positions within the dorsal spinal cord, [RefSeq, PubMed]; The protein encoded by this gene belongs to a family of secreted neuronal glycoproteins. The transcript is broadly expressed in the embryonic and adult brain with higher levels in some regions including the olfactory bulb, thalamus, and cerebral cortex. The protein can bind to presynaptic neurexins and induce synaptogenesis in cultured neurons. Null mutant mice are viable, fertile and do not display obvious neuroanatomical defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030545 signaling receptor regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0045202 synapse;GO:0043083 synaptic cleft;GO:0098820 trans-synaptic protein complex", "go_biological_process": "GO:0050808 synapse organization;GO:0051965 positive regulation of synapse assembly;GO:0099558 maintenance of synapse structure;GO:0099557 trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission;GO:0099550 trans-synaptic signaling, modulating synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q8BGU2-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH59-1", "uniprot_id": [ { "id": "S2512_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH59", "type": "external" } ], "mass": 74570.0, "length": 677, "protein_name": "Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial", "gene_name": "Slc25a12", "organism": "Mouse", "refseq_name": "electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial", "refseq_ac": [ { "id": "NP_766024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766024", "type": "external" } ], "gene_names_uniprotkb": "Slc25a12", "gene_names_refseq": "2610002D09Rik; B230107K20Rik; Slc25a12", "protein_names_uniprotkb": "Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial; Solute carrier family 25 member 12", "protein_names_refseq": "calcium-binding mitochondrial carrier protein Aralar1; electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial; mitochondrial aspartate glutamate carrier 1", "tax_id": 10090, "disease": "Asperger syndrome (Disease Ontology:DOID:0050432); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); autism spectrum disorder (Disease Ontology:DOID:0060041); neonatal-onset type II citrullinemia (Disease Ontology:DOID:0070341); developmental and epileptic encephalopathy 39 (Disease Ontology:DOID:0080349); autistic disorder (Disease Ontology:DOID:12849); intrahepatic cholestasis (Disease Ontology:DOID:1852); common bile duct disease (Disease Ontology:DOID:4137); citrullinemia (Disease Ontology:DOID:9273)", "pathway": " (mmu:78830); (R-MMU-8963693); (R-MMU-9856872)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "12084073;15987682;21750661;25428506;29187734;31219806;33300544;34203471;34428180;37453647;37507081;39627609;39927985", "class_list": "", "function": "Expression of the aspartate/glutamate mitochondrial carriers aralar1 and citrin during development, [RefSeq, PubMed]; Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle. Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (By similarity). Lacks transport activity towards L-glutamine or gamma-aminobutyric acid (GABA) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; These results show that aralar plays an important role in myelin formation by providing aspartate for the synthesis of N-acetylaspartate in neuronal cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BFG0", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0005313 L-glutamate transmembrane transporter activity;GO:0015172 acidic amino acid transmembrane transporter activity;GO:0015183 L-aspartate transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0043209 myelin sheath", "go_biological_process": "GO:2001171 positive regulation of ATP biosynthetic process;GO:0051592 response to calcium ion;GO:0010907 positive regulation of glucose metabolic process;GO:0031643 positive regulation of myelination;GO:0006537 glutamate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8BH59-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ND34-1", "uniprot_id": [ { "id": "WDR81_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5ND34", "type": "external" } ], "mass": 211945.0, "length": 1934, "protein_name": "WD repeat-containing protein 81", "gene_name": "Wdr81", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 81", "refseq_ac": [ { "id": "NP_620400", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620400", "type": "external" } ], "gene_names_uniprotkb": "Wdr81", "gene_names_refseq": "Gm883; Wdr81; mFLJ00182; nur5", "protein_names_uniprotkb": "WD repeat-containing protein 81", "protein_names_refseq": "WD repeat-containing protein 81; shakey 5", "tax_id": 10090, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 2 (Disease Ontology:DOID:0070557); microcephaly (Disease Ontology:DOID:10907); hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (mmu:192652)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "19144319;21750661;21885617;23595742;27802388;28404643;30531936;31219806;34428180", "class_list": "", "function": "Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (By similarity). May also be involved in maintenance of normal mitochondrial structure and organization (PubMed:23595742)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; This study provided evidence that the nur5 mutant mouse strain, which displays tremor and an abnormal gait, as well as Purkinje cell degeneration and photoreceptor cell loss, [RefSeq, PubMed]; WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGFbeta signaling., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "G5E8V0;Q3TA90;Q3TUS9;Q6KAR1", "ec_number_list": [], "go_molecular_function": "GO:0070530 K63-linked polyubiquitin modification-dependent protein binding;GO:0035014 phosphatidylinositol 3-kinase regulator activity;GO:0141039 phosphatidylinositol 3-kinase inhibitor activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0050821 protein stabilization;GO:0045022 early endosome to late endosome transport;GO:0007005 mitochondrion organization;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0035973 aggrephagy", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q5ND34-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U4F6-1", "uniprot_id": [ { "id": "DC2I2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5U4F6", "type": "external" } ], "mass": 58174.0, "length": 537, "protein_name": "Cytoplasmic dynein 2 intermediate chain 2", "gene_name": "Dync2i2", "organism": "Mouse", "refseq_name": "cytoplasmic dynein 2 intermediate chain 2", "refseq_ac": [ { "id": "NP_001008498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008498", "type": "external" } ], "gene_names_uniprotkb": "Dync2i2; Wdr34", "gene_names_refseq": "3200002I06Rik; Dync2i2; Wdr34", "protein_names_uniprotkb": "Cytoplasmic dynein 2 intermediate chain 2; Dynein 2 intermediate chain 2; WD repeat-containing protein 34", "protein_names_refseq": "WD repeat domain 34; WD repeat-containing protein 34; cytoplasmic dynein 2 intermediate chain 2", "tax_id": 10090, "disease": "neural tube defect (Disease Ontology:DOID:0080074); short-rib thoracic dysplasia 11 with or without polydactyly (Disease Ontology:DOID:0110095)", "pathway": " (mmu:71820); (R-MMU-5620924)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "19521662;21183079;24183451;28379358;31219806;35820727", "class_list": "", "function": "Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation., [UniProtKB, UniProtKB]; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. DYNC2I2 plays a major role in retrograde ciliary protein trafficking and in ciliogenesis (PubMed:28379358). Required also to maintain a functional transition zone (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BE91", "ec_number_list": [], "go_molecular_function": "GO:0045503 dynein light chain binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0060271 cilium assembly;GO:0042073 intraciliary transport;GO:0035721 intraciliary retrograde transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5U4F6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZPG2-1", "uniprot_id": [ { "id": "WDR90_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZPG2", "type": "external" } ], "mass": 202972.0, "length": 1874, "protein_name": "WD repeat-containing protein 90", "gene_name": "Wdr90", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 90 isoform 1", "refseq_ac": [ { "id": "NP_001157238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157238", "type": "external" } ], "gene_names_uniprotkb": "Wdr90; Kiaa1924", "gene_names_refseq": "3230401M21Rik; Wdr90; mKIAA1924", "protein_names_uniprotkb": "WD repeat-containing protein 90", "protein_names_refseq": "WD repeat-containing protein 90 isoform 1; WD repeat-containing protein 90", "tax_id": 10090, "disease": "", "pathway": " (mmu:106618)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20485683;21183079;21750661;25428506;31219806;34428180", "class_list": "", "function": "Microtubule-binding protein that plays a crucial role in ensuring inner core protein localization within the centriole core, as well as in maintaining the microtubule wall integrity and the overall centriole roundness and stability. Required for efficient primary cilium formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80VI2;Q8BI97;Q8R3G7;Q921X4", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0005814 centriole;GO:0034451 centriolar satellite", "go_biological_process": "GO:0060271 cilium assembly;GO:0061511 centriole elongation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6ZPG2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TMQ7-1", "uniprot_id": [ { "id": "WDR91_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TMQ7", "type": "external" } ], "mass": 83421.0, "length": 748, "protein_name": "WD repeat-containing protein 91", "gene_name": "Wdr91", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 91", "refseq_ac": [ { "id": "NP_001013384", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013384", "type": "external" } ], "gene_names_uniprotkb": "Wdr91", "gene_names_refseq": "9530020G05Rik; Wdr91", "protein_names_uniprotkb": "WD repeat-containing protein 91", "protein_names_refseq": "WD repeat-containing protein 91", "tax_id": 10090, "disease": "", "pathway": " (mmu:101240)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17242355;19144319;21750661;27346680;28860274;31219806;34028500;34428180", "class_list": "", "function": "Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (By similarity). May play a role in meiosis (PubMed:27346680)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; The Rab7 effector WDR91 promotes autophagy-lysosome degradation in neurons by regulating lysosome fusion., [RefSeq, PubMed]; WDR91 serves as a Rab7 effector that is essential for neuronal development by facilitating endosome conversion in the endosome-lysosome pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80XN1", "ec_number_list": [], "go_molecular_function": "GO:0035014 phosphatidylinositol 3-kinase regulator activity;GO:0141039 phosphatidylinositol 3-kinase inhibitor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane;GO:0010008 endosome membrane;GO:0005769 early endosome", "go_biological_process": "GO:0045022 early endosome to late endosome transport;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0042176 regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7TMQ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AKX3-1", "uniprot_id": [ { "id": "SETX_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AKX3", "type": "external" } ], "mass": 297589.0, "length": 2646, "protein_name": "Helicase senataxin", "gene_name": "Setx", "organism": "Mouse", "refseq_name": "helicase senataxin", "refseq_ac": [ { "id": "NP_932150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150", "type": "external" } ], "gene_names_uniprotkb": "Setx; Als4; Kiaa0625", "gene_names_refseq": "A130090N03; A930037J23Rik; AOA2; Als4; SCAR1; Sen1; Setx; mKIAA0625", "protein_names_uniprotkb": "Helicase senataxin; 5.6.2.3; Amyotrophic lateral sclerosis 4 protein homolog; RNA:DNA and DNA:DNA 5'-3' helicase Setx; SEN1 homolog", "protein_names_refseq": "SEN1 homolog; amyotrophic lateral sclerosis 4 homolog; amyotrophic lateral sclerosis 4 protein homolog; helicase senataxin; probable helicase senataxin", "tax_id": 10090, "disease": "spinocerebellar ataxia with axonal neuropathy 2 (Disease Ontology:DOID:0050755); amyotrophic lateral sclerosis type 4 (Disease Ontology:DOID:0060196)", "pathway": " (mmu:269254)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;14770181;16644229;18299400;20173027;21183079;21750661;22767893;23593030;25428506;30084848;30779550;31219806;31599954;34418053;34428180;36852467;37801077", "class_list": "", "function": "ATP-dependent 5'-3' helicase that preferentially unwinds RNA:DNA substrates over DNA:DNA substrates, playing a crucial role in resolving 5'-overhang RNA:DNA hybrids (R-loops) and promoting transcription termination. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription. Contributes to the mRNA splicing efficiency and splice site selection. Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (By similarity). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (PubMed:22767893). Involved in DNA double-strand breaks damage response generated by oxidative stress. In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (By similarity). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (PubMed:23593030). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis. May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; New allele of mouse DNA/RNA helicase senataxin causes meiotic arrest and infertility. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2AKX4;A2AR33;Q6IMG6;Q6PED8;Q6ZQ81;Q80V90;Q8C5P1;Q8C859;Q8C8P6", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0033677 DNA/RNA helicase activity;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0030424 axon", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0006310 DNA recombination;GO:0007283 spermatogenesis;GO:0007399 nervous system development;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "A2AKX3-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3USH5-1", "uniprot_id": [ { "id": "SFSWA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3USH5", "type": "external" } ], "mass": 104190.0, "length": 945, "protein_name": "Splicing factor, suppressor of white-apricot homolog", "gene_name": "Sfswap", "organism": "Mouse", "refseq_name": "splicing factor, suppressor of white-apricot homolog isoform 1", "refseq_ac": [ { "id": "NP_758480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758480", "type": "external" } ], "gene_names_uniprotkb": "Sfswap; Sfrs8; Srsf8; Swap", "gene_names_refseq": "1190005N23Rik; 6330437E22Rik; SWAP; Sfrs8; Sfswap; Srsf8", "protein_names_uniprotkb": "Splicing factor, suppressor of white-apricot homolog; Splicing factor, arginine/serine-rich 8; Suppressor of white apricot protein homolog", "protein_names_refseq": "serine/arginine-rich splicing factor 8; splicing factor, arginine/serine-rich 8; splicing factor, suppressor of white-apricot homolog isoform 1; splicing factor, suppressor of white-apricot homolog; suppressor of white apricot protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:231769)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17242355;17525332;21183079;21750661;24391519;31219806;34428180;34887587;36210013;40997131", "class_list": "", "function": "Plays a role as an alternative splicing regulator. Regulates its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10 (By similarity)., [UniProtKB]; We show that Jag1; Sfswap compound mutants have inner ear defects that are more severe than expected from simple additive effects of the single mutants, indicating a genetic interaction between Sfswap and Jag1, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8CCZ1", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0000380 alternative mRNA splicing, via spliceosome;GO:0000395 mRNA 5'-splice site recognition;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3USH5-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88569-1", "uniprot_id": [ { "id": "ROA2_MOUSE", "url": "https://www.uniprot.org/uniprot/O88569", "type": "external" } ], "mass": 37403.0, "length": 353, "protein_name": "Heterogeneous nuclear ribonucleoproteins A2/B1", "gene_name": "Hnrnpa2b1", "organism": "Mouse", "refseq_name": "heterogeneous nuclear ribonucleoproteins A2/B1 isoform 1", "refseq_ac": [ { "id": "NP_058086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058086", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpa2b1; Hnrpa2b1", "gene_names_refseq": "9130414A06Rik; Hnrnpa2b1; Hnrpa2b1; Hnrpa2; hnrnp-A", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2/B1", "protein_names_refseq": "heterogeneous nuclear ribonucleoproteins A2/B1 isoform 1; heterogeneous nuclear ribonucleoproteins A2/B1; heterogenous nuclear ribonucleoprotein A2/B1; hnRNP A2/B1", "tax_id": 10090, "disease": "inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2 (Disease Ontology:DOID:0111384); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); transient cerebral ischemia (Disease Ontology:DOID:224); lung non-small cell carcinoma (Disease Ontology:DOID:3908); pancreatic carcinoma (Disease Ontology:DOID:4905); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (mmu:53379); (R-MMU-72163); (R-MMU-72203); (R-MMU-9770562)", "pathway_count": 4, "publication_count": 28, "publication_id_list": "12242009;12243756;12546712;16393994;17242355;18630941;20485683;21183079;21750661;22872234;24129315;28011936;30084848;30779550;31219806;31320558;33725478;34428180;35820727;35984892;36288343;37453647;37507081;38017546;39349455;39627609;8133041;8265661", "class_list": "", "function": "Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (By similarity). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts. Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs. Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (By similarity). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity). Also plays a role in the activation of the innate immune response. Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6. In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; HnRNPA2B1 promotes the occurrence and progression of hepatocellular carcinoma by downregulating PCK1 mRNA via a m6A RNA methylation manner. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EJ02;Q3UVJ5;Q6PCV9;Q8C2A0;Q8CJ71;Q91ZR9;Q9R204", "ec_number_list": [], "go_molecular_function": "GO:0001069 regulatory region RNA binding;GO:0097157 pre-mRNA intronic binding;GO:0098505 G-rich strand telomeric DNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0014069 postsynaptic density", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0016233 telomere capping;GO:0048025 negative regulation of mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "O88569-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5IRJ6-1", "uniprot_id": [ { "id": "ZNT9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5IRJ6", "type": "external" } ], "mass": 62875.0, "length": 567, "protein_name": "Proton-coupled zinc antiporter SLC30A9, mitochondrial", "gene_name": "Slc30a9", "organism": "Mouse", "refseq_name": "proton-coupled zinc antiporter SLC30A9, mitochondrial isoform 2", "refseq_ac": [ { "id": "NP_001297558", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297558", "type": "external" } ], "gene_names_uniprotkb": "Slc30a9", "gene_names_refseq": "2310024J23Rik; GAC63; HUEL; Slc30a9; znT-9", "protein_names_uniprotkb": "Proton-coupled zinc antiporter SLC30A9, mitochondrial; GAC63; GRIP1-associated coactivator 63; Solute carrier family 30 member 9; Zinc transporter 9; ZnT-9", "protein_names_refseq": "GRIP1-associated coactivator 1; GRIP1-associated coactivator 63; proton-coupled zinc antiporter SLC30A9, mitochondrial isoform 2; proton-coupled zinc antiporter SLC30A9, mitochondrial; zinc transporter 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:109108)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11906820;15988012;16513642;17344318;21750661", "class_list": "", "function": "Acts as a zinc transporter involved in intracellular zinc homeostasis (By similarity). Functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtypes (PubMed:15988012). Plays a role in transcriptional activation of Wnt-responsive genes (PubMed:17344318)., [UniProtKB, PubMed, UniProtKB, PubMed]; GAC63 has a role in transcriptional activation mediated by the aryl hydrocarbon receptor, [RefSeq, PubMed]; GAC63 is a physiologically relevant part of the p160 coactivator signaling pathway that mediates transcriptional activation by nuclear receptors., [RefSeq, PubMed]; Mitochondrial proton-coupled zinc ion antiporter mediating the export of zinc from the mitochondria and involved in zinc homeostasis, zinc mobilization as well as mitochondrial morphology and health (By similarity). In nucleus, functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtypes. Plays a role in transcriptional activation of Wnt-responsive genes (PubMed:15988012, PubMed:17344318)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q66L46;Q7TNE9;Q8BGX8;Q8BUR1;Q8BZP2;Q8K2E0;Q8K376;Q8R0P1;Q9JK46", "ec_number_list": [], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0015297 antiporter activity;GO:0016922 nuclear receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005856 cytoskeleton;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006829 zinc ion transport;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006882 intracellular zinc ion homeostasis;GO:0010821 regulation of mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5IRJ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63325-1", "uniprot_id": [ { "id": "RS10_MOUSE", "url": "https://www.uniprot.org/uniprot/P63325", "type": "external" } ], "mass": 18916.0, "length": 165, "protein_name": "Small ribosomal subunit protein eS10", "gene_name": "Rps10", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein eS10 isoform 1", "refseq_ac": [ { "id": "NP_080239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080239", "type": "external" } ], "gene_names_uniprotkb": "Rps10", "gene_names_refseq": "2210402A09Rik; Rps10", "protein_names_uniprotkb": "Small ribosomal subunit protein eS10; 40S ribosomal protein S10", "protein_names_refseq": "40S ribosomal protein S10; small ribosomal subunit protein eS10 isoform 1; small ribosomal subunit protein eS10", "tax_id": 10090, "disease": "Diamond-Blackfan anemia 9 (Disease Ontology:DOID:0111884)", "pathway": " (mmu:67097); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 13, "publication_id_list": "15345747;17242355;17947660;21183079;21750661;24129315;31219806;34428180;35820727;36288343;36517592;37453647;37507081", "class_list": "", "function": "Component of the 40S ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]; Component of the 40S ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P09900;Q9DCR5", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0000049 tRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000028 ribosomal small subunit assembly;GO:0140236 translation at presynapse;GO:0140242 translation at postsynapse", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P63325-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TUF7-1", "uniprot_id": [ { "id": "YETS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TUF7", "type": "external" } ], "mass": 148950.0, "length": 1407, "protein_name": "YEATS domain-containing protein 2", "gene_name": "Yeats2", "organism": "Mouse", "refseq_name": "YEATS domain-containing protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001028409", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028409", "type": "external" } ], "gene_names_uniprotkb": "Yeats2; Kiaa1197", "gene_names_refseq": "Yeats2; mKIAA1197", "protein_names_uniprotkb": "YEATS domain-containing protein 2", "protein_names_refseq": "YEATS domain-containing protein 2 isoform 2; YEATS domain-containing protein 2", "tax_id": 10090, "disease": "familial adult myoclonic epilepsy 4 (Disease Ontology:DOID:0111693)", "pathway": " (mmu:208146); (R-MMU-9772755)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21606357;21750661;21952136;22517741;22645316;22872234;25428506;29237092;30084848;30779550;32782141;32848054;34428180;34678516;35820727;35822049;36852467;38619971;40021952;40885482;40997131", "class_list": "", "function": "Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Repression of YEATS2 induces cellular senescence in hepatocellular carcinoma and inhibits tumor growth., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 16, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 16, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 16, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "Q6PGF8;Q80TI2;Q8CG86", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0042393 histone binding;GO:0140030 modification-dependent protein binding;GO:0017025 TBP-class protein binding;GO:0140566 histone reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035267 NuA4 histone acetyltransferase complex;GO:0072686 mitotic spindle;GO:0140672 ATAC complex", "go_biological_process": "GO:0090043 regulation of tubulin deacetylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "Q3TUF7-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZX6-1", "uniprot_id": [ { "id": "SENP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZX6", "type": "external" } ], "mass": 67579.0, "length": 588, "protein_name": "Sentrin-specific protease 2", "gene_name": "Senp2", "organism": "Mouse", "refseq_name": "sentrin-specific protease 2 isoform 1", "refseq_ac": [ { "id": "NP_083733", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083733", "type": "external" } ], "gene_names_uniprotkb": "Senp2; Smt3ip2; Supr1", "gene_names_refseq": "2310007L05Rik; 4930538C18Rik; Senp2; Smt3ip2; SuPr-1; mKIAA1331", "protein_names_uniprotkb": "Sentrin-specific protease 2; 3.4.22.-; Axam2; SUMO-1 protease 1; SUMO-1/Smt3-specific isopeptidase 2; Sentrin/SUMO-specific protease SENP2; Smt3ip2; SuPr-1", "protein_names_refseq": "SUMO-1 protease-1; SUMO-1/Smt3-specific isopeptidase 2; SUMO/sentrin specific protease 2; axam2; sentrin-specific protease 2 isoform 1; sentrin-specific protease 2; sentrin/SUMO-specific protease SENP2", "tax_id": 10090, "disease": "", "pathway": " (mmu:75826); (R-MMU-3065679)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11489887;12419228;19090619;20194620;21750661;25689261;27637147;34428180;36543805;36872063;37301920;37462038", "class_list": "", "function": "Activates transcription., [UniProtKB, PubMed]; Data reveal a key genetic pathway, SENP2-Mdm2-p53, underlying trophoblast lineage development, suggesting its pivotal role in cell cycle progression of mitosis and endoreduplication., [RefSeq, PubMed]; Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Protease that catalyzes two essential functions in the SUMO pathway (PubMed:11489887, PubMed:20194620). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (By similarity). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:11489887, PubMed:20194620, PubMed:27637147). May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (PubMed:11489887). Deconjugates SUMO2 from MTA1 (By similarity). Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620). Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection (PubMed:27637147)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Role of SUMO-Specific Protease 2 in Leptin-Induced Fatty Acid Metabolism in White Adipocytes., [RefSeq, PubMed]; SENP2 restrains the generation of pathogenic Th17 cells in mouse models of colitis. Publication Status: Online-Only, [RefSeq, PubMed]; SENP2-mediated SERCA2a deSUMOylation increases calcium overload in cardiomyocytes to aggravate myocardial ischemia/reperfusion injury., [RefSeq, PubMed]; SUMO-1 protease-1 regulates gene transcription through PML., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q544T8;Q811R3;Q9D4Z0", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" } ], "go_molecular_function": "GO:0016929 deSUMOylase activity;GO:0019904 protein domain specific binding;GO:0070139 SUMO-specific endopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0007507 heart development;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q91ZX6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47708-1", "uniprot_id": [ { "id": "RP3A_MOUSE", "url": "https://www.uniprot.org/uniprot/P47708", "type": "external" } ], "mass": 75489.0, "length": 681, "protein_name": "Rabphilin-3A", "gene_name": "Rph3a", "organism": "Mouse", "refseq_name": "rabphilin-3A isoform 1", "refseq_ac": [ { "id": "NP_001289273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289273", "type": "external" } ], "gene_names_uniprotkb": "Rph3a", "gene_names_refseq": "2900002P20Rik; Rph3a", "protein_names_uniprotkb": "Rabphilin-3A; Exophilin-1", "protein_names_refseq": "Doc2 family; exophilin-1; rabphilin-3A isoform 1", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (mmu:19894)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10407024;12578829;17114649;18945677;21183079;21750661;22517741;22645316;24129315;30059200;31924649;32848054;33753311;40885482;7822236", "class_list": "", "function": "Ca(2+) sensor proteins in spontaneous release and synaptic plasticity: Limited contribution of Doc2c, rabphilin-3a and synaptotagmin 7 in hippocampal glutamatergic neurons., [RefSeq, PubMed]; Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (By similarity). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone (By similarity)., [UniProtKB, UniProtKB]; Small GTPase ARF6 Is a Coincidence-Detection Code for RPH3A Polarization in Neutrophil Polarization., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0030141 secretory granule;GO:0031594 neuromuscular junction;GO:0043197 dendritic spine;GO:0045202 synapse", "go_biological_process": "GO:0006886 intracellular protein transport;GO:2000310 regulation of NMDA receptor activity;GO:0097061 dendritic spine organization;GO:0045956 positive regulation of calcium ion-dependent exocytosis;GO:0061669 spontaneous neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P47708-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97760-1", "uniprot_id": [ { "id": "RPB3_MOUSE", "url": "https://www.uniprot.org/uniprot/P97760", "type": "external" } ], "mass": 31443.0, "length": 275, "protein_name": "DNA-directed RNA polymerase II subunit RPB3", "gene_name": "Polr2c", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase II subunit RPB3", "refseq_ac": [ { "id": "NP_033116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033116", "type": "external" } ], "gene_names_uniprotkb": "Polr2c; Rpo2-3", "gene_names_refseq": "33kDa; Polr2c; RPB3; Rpo2-3; mRBP31", "protein_names_uniprotkb": "DNA-directed RNA polymerase II subunit RPB3; DNA-directed RNA polymerase II 33 kDa polypeptide; DNA-directed RNA polymerase II subunit C; RNA polymerase II subunit 3; RNA polymerase II subunit B3; RPB31; RPB33", "protein_names_refseq": "DNA-directed RNA polymerase II 33 kDa polypeptide; DNA-directed RNA polymerase II subunit C; DNA-directed RNA polymerase II subunit RPB3; RNA polymerase II subunit 3; RNA polymerase II subunit B3; RPB31; RPB33", "tax_id": 10090, "disease": "", "pathway": " (mmu:20021); (R-MMU-112382); (R-MMU-113418); (R-MMU-674695); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6796648); (R-MMU-6803529); (R-MMU-6807505); (R-MMU-72086); (R-MMU-72163); (R-MMU-72165); (R-MMU-72203); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-75955); (R-MMU-76042); (R-MMU-77075); (R-MMU-9018519); (R-MMU-9770562)", "pathway_count": 22, "publication_count": 5, "publication_id_list": "16452087;21750661;25428506;34428180;9034305", "class_list": "", "function": "Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99M46", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005665 RNA polymerase II, core complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P97760-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z138-1", "uniprot_id": [ { "id": "ROR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z138", "type": "external" } ], "mass": 105005.0, "length": 944, "protein_name": "Tyrosine-protein kinase transmembrane receptor ROR2", "gene_name": "Ror2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ror2", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein kinase transmembrane receptor ROR2; 2.7.10.1; Neurotrophic tyrosine kinase, receptor-related 2; mROR2", "protein_names_refseq": "", "tax_id": 10090, "disease": "autosomal recessive Robinow syndrome (Disease Ontology:DOID:0060764); brachydactyly type B1 (Disease Ontology:DOID:0110969); cleft palate (Disease Ontology:DOID:674)", "pathway": " (R-MMU-5140745)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10231392;10700181;19785987;21750661;24129315;35820727", "class_list": "", "function": "Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (PubMed:10700181). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation. In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QKB3", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0005109 frizzled binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0017147 Wnt-protein binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon", "go_biological_process": "GO:0007165 signal transduction;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0030154 cell differentiation;GO:0030335 positive regulation of cell migration;GO:0042472 inner ear morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Z138-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925F4-1", "uniprot_id": [ { "id": "RNF37_MOUSE", "url": "https://www.uniprot.org/uniprot/Q925F4", "type": "external" } ], "mass": 58732.0, "length": 539, "protein_name": "RING finger protein 37", "gene_name": "Ubox5", "organism": "Mouse", "refseq_name": "RING finger protein 37", "refseq_ac": [ { "id": "NP_001242922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001242922", "type": "external" } ], "gene_names_uniprotkb": "Ubox5; Rnf37; Uip5", "gene_names_refseq": "1500010O06Rik; C330018L13Rik; Rnf37; UIP5; Ubce7ip5; Ube7ip5; Ubox5", "protein_names_uniprotkb": "RING finger protein 37; 2.3.2.27; RING-type E3 ubiquitin transferase RNF37; U-box domain-containing protein 5; UbcM4-interacting protein 5", "protein_names_refseq": "RING finger protein 37; RING-type E3 ubiquitin transferase RNF37; U-box domain-containing protein 5; UbcM4-interacting protein 5; ubiquitin-conjugating enzyme 7-interacting protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:140629); (R-MMU-983168)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11274149;11435423;15189447;21750661;34428180", "class_list": "", "function": "May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0061630 ubiquitin protein ligase activity;GO:0034450 ubiquitin-ubiquitin ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005925 focal adhesion;GO:0016604 nuclear body", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0044528 regulation of mitochondrial mRNA stability", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q925F4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQ00-1", "uniprot_id": [ { "id": "ROP1L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQ00", "type": "external" } ], "mass": 24516.0, "length": 218, "protein_name": "Ropporin-1-like protein", "gene_name": "Ropn1l", "organism": "Mouse", "refseq_name": "ropporin-1-like protein", "refseq_ac": [ { "id": "NP_665851", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665851", "type": "external" } ], "gene_names_uniprotkb": "Ropn1l; Asp", "gene_names_refseq": "ASP; Akapasp; Ropn1l", "protein_names_uniprotkb": "Ropporin-1-like protein; AKAP-associated sperm protein", "protein_names_refseq": "A-kinase anchoring protein-associated sperm protein; AKAP-associated sperm protein; ropporin-1-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:252967)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11278869;12021058;22021175;23303679;25428506;27398160;36417862", "class_list": "", "function": "Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia (PubMed:36417862). Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation., [UniProtKB, PubMed, PubMed]; Mutations in ROPN1 and ROPN1L can cause defects in fibrous sheath integrity, sperm motility, and PKA-dependent signaling processes, leading to male infertility. Publication Status: Online-Only, [RefSeq, PubMed]; Northern blot analysis of testis RNA from 5-, 15-, 25-, and 40-day-old mice showed expression of the ASP gene and in situ hybridization analysis localized the ASP mRNA to the germ cell compartment of the seminiferous tubules in the testis, [RefSeq, PubMed]; The beat frequency of cilia from mice lacking ASP is significantly slower than wild type, indicating that ASP signaling may regulate ciliary motility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P8Z9", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0001534 radial spoke;GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0030317 flagellated sperm motility;GO:0048240 sperm capacitation;GO:0001932 regulation of protein phosphorylation;GO:0003341 cilium movement", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9EQ00-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYK7-1", "uniprot_id": [ { "id": "RNF11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYK7", "type": "external" } ], "mass": 17458.0, "length": 154, "protein_name": "RING finger protein 11", "gene_name": "Rnf11", "organism": "Mouse", "refseq_name": "RING finger protein 11", "refseq_ac": [ { "id": "NP_038904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038904", "type": "external" } ], "gene_names_uniprotkb": "Rnf11; N4wbp2; Sid1669", "gene_names_refseq": "Rnf11", "protein_names_uniprotkb": "RING finger protein 11; NEDD4 WW domain-binding protein 2; Sid 1669", "protein_names_refseq": "NEDD4 WW domain-binding protein 2; RING finger protein 11; sid 1669", "tax_id": 10090, "disease": "", "pathway": " (mmu:29864)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10673045;11042109;19131965;19144319;21183079;21750661;22975135;26495903;28011936;34642330", "class_list": "", "function": "Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism. Publication Status: Online-Only, [RefSeq, PubMed]; Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome., [UniProtKB, UniProtKB, UniProtKB]; Microglial RNF11 is a negative regulator of NF-kappaB signalling pathway and could be a strong potential target for modulating inflammatory responses in neurodegenerative diseases., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AU36;B1AU37;Q9EQI1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005769 early endosome;GO:0055037 recycling endosome;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9QYK7-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99NB9-1", "uniprot_id": [ { "id": "SF3B1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99NB9", "type": "external" } ], "mass": 145816.0, "length": 1304, "protein_name": "Splicing factor 3B subunit 1", "gene_name": "Sf3b1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sf3b1; Sap155", "gene_names_refseq": "", "protein_names_uniprotkb": "Splicing factor 3B subunit 1; Pre-mRNA-splicing factor SF3b 155 kDa subunit; SAP 155; SF3b155; Spliceosome-associated protein 155", "protein_names_refseq": "", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); uterine corpus endometrial carcinoma (Disease Ontology:DOID:0050939); bladder urothelial carcinoma (Disease Ontology:DOID:4006); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:81898); (R-MMU-5250924); (R-MMU-72163); (R-MMU-72165); (R-MMU-9770562)", "pathway_count": 5, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;11252167;17242355;18299400;18938227;20484733;21183079;21750661;21952136;23806337;24463520;25428506;26255770;29187734;29617656;30084848;31219806;33300544;34203471;34428180;34887587;35820727;36210013;39627609", "class_list": "", "function": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (By similarity). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (By similarity). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (By similarity). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (By similarity). May also be involved in the assembly of the 'E' complex (By similarity). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (PubMed:26255770)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 37, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 5, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q9CSK5", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:1990935 splicing factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0016363 nuclear matrix", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification;GO:0045945 positive regulation of transcription by RNA polymerase III;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q99NB9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QUR8-1", "uniprot_id": [ { "id": "SEM7A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QUR8", "type": "external" } ], "mass": 74994.0, "length": 664, "protein_name": "Semaphorin-7A", "gene_name": "Sema7a", "organism": "Mouse", "refseq_name": "semaphorin-7A precursor", "refseq_ac": [ { "id": "NP_035482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035482", "type": "external" } ], "gene_names_uniprotkb": "Sema7a; Cd108; Semal; Semk1", "gene_names_refseq": "2900057C09Rik; CDw108; H-Sema K1; H-Sema-L; M-Sema-L; Sema7a; Semal; sema K1; sema L", "protein_names_uniprotkb": "Semaphorin-7A; Sema K1; Sema L; Semaphorin-K1; Semaphorin-L", "protein_names_refseq": "semaphorin-7A precursor; semaphorin-7A; semaphorin-K1; semaphorin-L", "tax_id": 10090, "disease": "progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221)", "pathway": " (mmu:20361); (R-MMU-416700)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10885563;12879062;16713976;17377534;21750661;24129315;26495903;28011936;30899004;32152506;34428180;34585848;37828378;9721204;9878861", "class_list": "", "function": "Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 10, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O88371", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0030215 semaphorin receptor binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0098793 presynapse", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0006954 inflammatory response;GO:0007229 integrin-mediated signaling pathway;GO:0030335 positive regulation of cell migration;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q9QUR8-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2B3-1", "uniprot_id": [ { "id": "SDHA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2B3", "type": "external" } ], "mass": 72585.0, "length": 664, "protein_name": "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "gene_name": "Sdha", "organism": "Mouse", "refseq_name": "succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor", "refseq_ac": [ { "id": "NP_075770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075770", "type": "external" } ], "gene_names_uniprotkb": "Sdha", "gene_names_refseq": "1500032O14Rik; 2310034D06Rik; 4921513A11; FP; SDH2; SDHF; Sdha", "protein_names_uniprotkb": "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; 1.1.5.-; 1.3.5.1; Flavoprotein subunit of complex II; Fp; Malate dehydrogenase [quinone] flavoprotein subunit", "protein_names_refseq": "E3-10 Sdha; flavoprotein subunit of complex II; malate dehydrogenase [quinone] flavoprotein subunit; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); pheochromocytoma (Disease Ontology:DOID:0050771); paraganglioma (Disease Ontology:DOID:0050773); mitochondrial complex II deficiency (Disease Ontology:DOID:0060537); pheochromocytoma/paraganglioma syndrome 5 (Disease Ontology:DOID:0061220); dilated cardiomyopathy 1GG (Disease Ontology:DOID:0110435); leukodystrophy (Disease Ontology:DOID:10579); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); Leigh disease (Disease Ontology:DOID:3652); pituitary adenoma (Disease Ontology:DOID:3829); lung non-small cell carcinoma (Disease Ontology:DOID:3908); gastrointestinal stromal tumor (Disease Ontology:DOID:9253)", "pathway": " (mmu:66945); (R-MMU-71403); (R-MMU-9854311)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "16751257;21750661;21858060;23576753;23806337;26495903;29187734;33300544;34428180;34887587;36288343;37453647;37507081;37828378;39927985", "class_list": "glycogene", "function": "Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity). Can act as a tumor suppressor (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 30, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0QF19;Q3UH25;Q3UKP7;Q3V4B1;Q921P5;Q9Z1Z4", "ec_number_list": [ { "id": "1.3.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.5.1", "type": "external" }, { "id": "1.1.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.5.-", "type": "external" } ], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0050660 flavin adenine dinucleotide binding;GO:0008177 succinate dehydrogenase (quinone) activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0043209 myelin sheath", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0007399 nervous system development;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0022904 respiratory electron transport chain;GO:0006105 succinate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8K2B3-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70274-1", "uniprot_id": [ { "id": "SEPP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P70274", "type": "external" } ], "mass": 42706.0, "length": 380, "protein_name": "Selenoprotein P", "gene_name": "Selenop", "organism": "Mouse", "refseq_name": "selenoprotein P precursor", "refseq_ac": [ { "id": "NP_001036078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036078", "type": "external" } ], "gene_names_uniprotkb": "Selenop; Selp; Sepp1", "gene_names_refseq": "D15Ucla1; Se-P; Selenop; Sepp1; selp", "protein_names_uniprotkb": "Selenoprotein P; Plasma selenoprotein P; SeP", "protein_names_refseq": "plasma selenoprotein P; seP; selenoprotein P precursor; selenoprotein P, plasma, 1", "tax_id": 10090, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal carcinoma (Disease Ontology:DOID:0080199); systemic scleroderma (Disease Ontology:DOID:418)", "pathway": " (mmu:20363)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;18174160;21750661;22872234;23064117;26495903;31219806;32152506;34428180;36947851;37166989;37984217;9288402;9687017", "class_list": "", "function": "Differences in serum selenoprotein P profile between C57BL/6 and BALB/c mice fed high-fat diet., [RefSeq, PubMed]; Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium (By similarity). May supply selenium to tissues such as brain and testis., [UniProtKB]; Results emphasize the importance of non-coding transcript variations as a regulatory means for Sepp1 expression in different tissues and stages of development; presence of a variant localized in the hippocampus and regulated by a microRNA may have implications for deficits in synaptic function caused by genetic deletion of Sepp1, [RefSeq, PubMed]; SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions. Publication Status: Online-Only, [RefSeq, PubMed]; Selenoprotein P deficiency protects against immobilization-induced muscle atrophy by suppressing atrophy-related E3 ubiquitin ligases., [RefSeq, PubMed]; This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in mouse), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. Alternatively spliced transcript variants differing in 5' non-coding region have been described for this gene. Expression of these variants varies in different tissues and developmental stages (PMID:23064117). [provided by RefSeq, Feb 2017]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJ31;Q3TXG8;Q6PKE7;Q80T08;Q80UF3;Q9Z2T7", "ec_number_list": [], "go_molecular_function": "GO:0008430 selenium binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007626 locomotory behavior;GO:0040008 regulation of growth;GO:0007420 brain development;GO:0009791 post-embryonic development;GO:0010269 response to selenium ion", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P70274-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EP97-1", "uniprot_id": [ { "id": "SENP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EP97", "type": "external" } ], "mass": 64403.0, "length": 568, "protein_name": "Sentrin-specific protease 3", "gene_name": "Senp3", "organism": "Mouse", "refseq_name": "sentrin-specific protease 3", "refseq_ac": [ { "id": "NP_001157043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157043", "type": "external" } ], "gene_names_uniprotkb": "Senp3; Smt3ip1; Smt3ip", "gene_names_refseq": "Senp3; Smt3ip1; Smt3ip", "protein_names_uniprotkb": "Sentrin-specific protease 3; 3.4.22.-; SUMO-1-specific protease 3; Sentrin/SUMO-specific protease SENP3; Smt3-specific isopeptidase 1; Smt3ip1", "protein_names_refseq": "SUMO-1-specific protease 3; SUMO/sentrin specific protease 3; sentrin-specific protease 3; sentrin/SUMO-specific protease SENP3; smt3-specific isopeptidase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:80886); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10806345;11029585;17242355;18948745;21183079;21750661;22872234;22872859;25153642;27802388;28528544;31219806;36210013;38925188;39025016", "class_list": "", "function": "Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:11029585). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (By similarity). Deconjugates SUMO2 and SUMO3 from CDCA8 (By similarity). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (By similarity). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (By similarity). Plays a role in the regulation of sumoylation status of ZNF148 (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (By similarity). Catalyzes desumoylation of MRE11 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; SENP3 sensitizes macrophages to ferroptosis via de-SUMOylation of FSP1., [RefSeq, PubMed]; SENP3-regulated Nodal signaling plays a potential role in cardiac left-right asymmetry development., [RefSeq, PubMed]; The p53-independent tumor suppressive functions of p19(Arf) may be mediated by its ability to antagonize Senp3, thereby inducing cell cycle arrest by abnormally elevating the cellular levels of SUMOylated proteins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5F2A5;Q8BRD5;Q8C2H5", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" } ], "go_molecular_function": "GO:0016929 deSUMOylase activity;GO:0008234 cysteine-type peptidase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0006508 proteolysis;GO:0016926 protein desumoylation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9EP97-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62205-1", "uniprot_id": [ { "id": "SCN9A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62205", "type": "external" } ], "mass": 225813.0, "length": 1984, "protein_name": "Sodium channel protein type 9 subunit alpha", "gene_name": "Scn9a", "organism": "Mouse", "refseq_name": "sodium channel protein type 9 subunit alpha isoform a", "refseq_ac": [ { "id": "NP_001277603", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277603", "type": "external" } ], "gene_names_uniprotkb": "Scn9a; Kiaa4197", "gene_names_refseq": "Nav1.7; PN1; Scn9a; mKIAA4197", "protein_names_uniprotkb": "Sodium channel protein type 9 subunit alpha; PN1; Peripheral sodium channel 1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7", "protein_names_refseq": "peripheral sodium channel 1; sodium channel 25; sodium channel protein type 9 subunit alpha isoform a; sodium channel protein type 9 subunit alpha; sodium channel, voltage-gated, type IX, alpha polypeptide; voltage-gated sodium channel alpha subunit Nav1.7", "tax_id": 10090, "disease": "generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); Dravet syndrome (Disease Ontology:DOID:0080422); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); paroxysmal extreme pain disorder (Disease Ontology:DOID:0111537); epilepsy (Disease Ontology:DOID:1826); anxiety disorder (Disease Ontology:DOID:2030); erythromelalgia (Disease Ontology:DOID:9240)", "pathway": " (mmu:20274)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;15123669;15314237;21750661;31647222;34428180;37117223", "class_list": "", "function": "Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient., [UniProtKB, UniProtKB, UniProtKB]; Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes (By similarity). Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient (By similarity). The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (By similarity). Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain (PubMed:15314237)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 5, "disease_count": 7, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A2ASI7;Q5DTI0", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005272 sodium channel activity;GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0043679 axon terminus;GO:0033268 node of Ranvier;GO:0001518 voltage-gated sodium channel complex", "go_biological_process": "GO:0061368 behavioral response to formalin induced pain;GO:0006954 inflammatory response;GO:0019228 neuronal action potential;GO:0019233 sensory perception of pain;GO:0050965 detection of temperature stimulus involved in sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q62205-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54951-1", "uniprot_id": [ { "id": "SEM6B_MOUSE", "url": "https://www.uniprot.org/uniprot/O54951", "type": "external" } ], "mass": 95467.0, "length": 886, "protein_name": "Semaphorin-6B", "gene_name": "Sema6b", "organism": "Mouse", "refseq_name": "semaphorin-6B precursor", "refseq_ac": [ { "id": "NP_001123928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123928", "type": "external" } ], "gene_names_uniprotkb": "Sema6b; Seman", "gene_names_refseq": "Sema6b; Seman; Sema; VIb; semaZ", "protein_names_uniprotkb": "Semaphorin-6B; Sema N; Sema VIB; Semaphorin VIB; Semaphorin-N", "protein_names_refseq": "sema N; sema VIB; semaphorin VIB; semaphorin-6B precursor; semaphorin-6B; semaphorin-N", "tax_id": 10090, "disease": "progressive myoclonus epilepsy (Disease Ontology:DOID:891)", "pathway": " (mmu:20359)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20484647;24129315;25428506;32169168;9361278", "class_list": "", "function": "Functions as a cell surface repellent for mossy fibers of developing neurons in the hippocampus where it plays a role in axon guidance (PubMed:20484647). May function through the PLXNA4 receptor expressed by mossy cell axons (PubMed:20484647)., [UniProtKB, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0021766 hippocampus development;GO:0007417 central nervous system development;GO:0001755 neural crest cell migration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O54951-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TKT4-1", "uniprot_id": [ { "id": "SMCA4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TKT4", "type": "external" } ], "mass": 181427.0, "length": 1613, "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4", "gene_name": "Smarca4", "organism": "Mouse", "refseq_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 isoform 1", "refseq_ac": [ { "id": "NP_001167549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001167549", "type": "external" } ], "gene_names_uniprotkb": "Smarca4; Baf190a; Brg1; Snf2b; Snf2l4", "gene_names_refseq": "BAF190A; Brg1; HP1-BP72; SNF2beta; SW1/SNF; Smarca4; b2b508.1Clo; b2b692Clo", "protein_names_uniprotkb": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; 3.6.4.-; BAF190A; BRG1-associated factor 190A; Protein brahma homolog 1; SMARCA4; SNF2-beta; Transcription activator BRG1", "protein_names_refseq": "ATP-dependent helicase SMARCA4; BRG1-associated factor 190A; SNF2-beta; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 isoform 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; protein brahma homolog 1; transcription activator BRG1", "tax_id": 10090, "disease": "opportunistic bacterial infectious disease (Disease Ontology:DOID:0050340); rhabdoid tumor predisposition syndrome 2 (Disease Ontology:DOID:0060997); Coffin-Siris syndrome 4 (Disease Ontology:DOID:0070046); Nicolaides-Baraitser syndrome (Disease Ontology:DOID:0081441); prostate cancer (Disease Ontology:DOID:10283); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:20586); (R-MMU-1266695); (R-MMU-201722); (R-MMU-3214858); (R-MMU-3247509); (R-MMU-8939243); (R-MMU-9764725); (R-MMU-9933937); (R-MMU-9933939); (R-MMU-9933946); (R-MMU-9933947); (R-MMU-9934037)", "pathway_count": 12, "publication_count": 25, "publication_id_list": "16424906;17242355;17640523;19144319;21095589;21183079;21750661;22162999;22872234;22952240;25428506;26138476;26601204;29187734;29374058;30084848;30779550;31219806;32459350;34203471;34428180;34910916;36852467;37399313;39627609", "class_list": "", "function": "ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:17640523). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role in regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (PubMed:17640523). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (By similarity). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (PubMed:26138476). Binds to RNA in a promiscuous manner (PubMed:26138476). In brown adipose tissue, involved in the regulation of thermogenic genes expression (PubMed:34910916)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUD7;Q6AXG8", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.37", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005726 perichromatin fibrils;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016514 SWI/SNF complex", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:1902459 positive regulation of stem cell population maintenance;GO:1902661 positive regulation of glucose mediated signaling pathway;GO:2000819 regulation of nucleotide-excision repair;GO:0060318 definitive erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q3TKT4-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ER00-1", "uniprot_id": [ { "id": "STX12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ER00", "type": "external" } ], "mass": 31195.0, "length": 274, "protein_name": "Syntaxin-12", "gene_name": "Stx12", "organism": "Mouse", "refseq_name": "syntaxin-12", "refseq_ac": [ { "id": "NP_598648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598648", "type": "external" } ], "gene_names_uniprotkb": "Stx12", "gene_names_refseq": "Stx12; Stx13", "protein_names_uniprotkb": "Syntaxin-12", "protein_names_refseq": "syntaxin 13; syntaxin-12", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305)", "pathway": " (mmu:100226)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12070131;12172780;16075062;17322886;19144319;20098723;25428506;26495903;28855648;30084848;30779550;34428180;35820727", "class_list": "", "function": "SNARE promoting fusion of transport vesicles with target membranes. Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting., [UniProtKB, UniProtKB]; The developmentally regulated syntaxin 13 expression in various neuronal populations is consistent with its involvement in endocytic trafficking and neurite outgrowth., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UIV9;Q921T9", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098837 postsynaptic recycling endosome;GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006886 intracellular protein transport;GO:0033344 cholesterol efflux;GO:0050821 protein stabilization;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9ER00-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2I9-1", "uniprot_id": [ { "id": "SUCB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2I9", "type": "external" } ], "mass": 50114.0, "length": 463, "protein_name": "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial", "gene_name": "Sucla2", "organism": "Mouse", "refseq_name": "succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_035636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035636", "type": "external" } ], "gene_names_uniprotkb": "Sucla2", "gene_names_refseq": "4930547K18Rik; A-SCS; SCS-betaA; Sucla2", "protein_names_uniprotkb": "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; 6.2.1.-; 6.2.1.5; 6.2.1.9; A-SCS; ATP-specific succinyl-CoA synthetase subunit beta; Itaconyl--CoA ligase [ADP-forming] subunit beta; Malyl--CoA ligase [ADP-forming] subunit beta; SCS-betaA; Succinyl-CoA synthetase beta-A chain", "protein_names_refseq": "ATP-specific succinyl-CoA synthetase subunit beta; itaconyl--CoA ligase [ADP-forming] subunit beta; malyl--CoA ligase [ADP-forming] subunit beta; succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial isoform 1 precursor; succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial; succinyl-CoA synthetase beta-A chain", "tax_id": 10090, "disease": "mitochondrial DNA depletion syndrome 5 (Disease Ontology:DOID:0080124)", "pathway": " (mmu:20916); (R-MMU-71403)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "15234968;17114649;17242355;21183079;22645316;23576753;23806337;24271779;28769029;33300544;33991485;34428180;36288343;37453647;37507081;39927985;9765291", "class_list": "", "function": "ADP and GDP succinyl-CoA synthetases have different expression patterns and specificity, [RefSeq, PubMed]; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Also able to act as an ATP-specific itaconyl- and malyl-CoA synthetase., [UniProtKB, HAMAP]; SCS A-beta loss mediates severe mitochondrial dysfunction including compromised OXPHOS efficiency, increased ROS generation, mtDNA depletion as well as altered mitochondrial dynamics towards fusion. Publication Status: Online-Only, [RefSeq, PubMed]; SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells., [RefSeq, PubMed]; Sucla2(SAbetageo) homozygotes exhibited recessive lethality, with most mutants dying late in gestation (e18.5). Mutant placenta and embryonic (e17.5) brain, heart and muscle showed varying degrees of mitochondrial DNA depletion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVH1;Q8BGS6", "ec_number_list": [ { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "6.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.5", "type": "external" }, { "id": "6.2.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.9", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0004775 succinate-CoA ligase (ADP-forming) activity;GO:0004774 succinate-CoA ligase activity;GO:0050074 malate-CoA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0043209 myelin sheath;GO:1902494 catalytic complex;GO:0042709 succinate-CoA ligase complex", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006104 succinyl-CoA metabolic process;GO:0006105 succinate metabolic process;GO:0006108 malate metabolic process;GO:0110052 toxic metabolite repair", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9Z2I9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJL8-1", "uniprot_id": [ { "id": "SYSM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJL8", "type": "external" } ], "mass": 58316.0, "length": 518, "protein_name": "Serine--tRNA ligase, mitochondrial", "gene_name": "Sars2", "organism": "Mouse", "refseq_name": "serine--tRNA ligase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_076126", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076126", "type": "external" } ], "gene_names_uniprotkb": "Sars2; Sarsm", "gene_names_refseq": "2410015F05Rik; D7Ertd353e; Sars2; SerRSmt; SerRS", "protein_names_uniprotkb": "Serine--tRNA ligase, mitochondrial; 6.1.1.11; SerRSmt; SerRS; Seryl-tRNA synthetase; Seryl-tRNA(Ser/Sec) synthetase", "protein_names_refseq": "serine--tRNA ligase, mitochondrial precursor; serine--tRNA ligase, mitochondrial; seryl-tRNA synthetase, mitochondrial; seryl-tRNA(Ser/Sec) synthetase", "tax_id": 10090, "disease": "", "pathway": " (mmu:71984)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10764807;15081407;17179180;21750661;23576753;23806337;25428506;28135057;30084848", "class_list": "", "function": "Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)., [UniProtKB, UniProtKB]; Identification of an array of 4 CCAAT box elements required for efficient transcription of the Sars2 gene., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q68FL2;Q9CWP1", "ec_number_list": [ { "id": "6.1.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.11", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0004828 serine-tRNA ligase activity;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006434 seryl-tRNA aminoacylation;GO:0070158 mitochondrial seryl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9JJL8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0N9-1", "uniprot_id": [ { "id": "SYT9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0N9", "type": "external" } ], "mass": 56265.0, "length": 491, "protein_name": "Synaptotagmin-9", "gene_name": "Syt9", "organism": "Mouse", "refseq_name": "synaptotagmin-9", "refseq_ac": [ { "id": "NP_068689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068689", "type": "external" } ], "gene_names_uniprotkb": "Syt9; Syt5", "gene_names_refseq": "Syt9", "protein_names_uniprotkb": "Synaptotagmin-9; Synaptotagmin IX; Synaptotagmin V; SytIX", "protein_names_refseq": "synaptotagmin V; synaptotagmin-9; sytIX", "tax_id": 10090, "disease": "", "pathway": " (mmu:60510); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10531343;10531344;10871604;20847230;21183079;21750661;36732068;36898834;37432648", "class_list": "", "function": "Genetic ablation of synaptotagmin-9 alters tomosyn-1 function to increase insulin secretion from pancreatic beta-cells improving glucose clearance., [RefSeq, PubMed]; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis., [UniProtKB]; Synaptotagmin 9 Modulates Spontaneous Neurotransmitter Release in Striatal Neurons by Regulating Substance P Secretion., [RefSeq, PubMed]; The Cytidine N-Acetyltransferase NAT10 Participates in Peripheral Nerve Injury-Induced Neuropathic Pain by Stabilizing SYT9 Expression in Primary Sensory Neurons., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0R7;Q8C280", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030141 secretory granule;GO:0030672 synaptic vesicle membrane;GO:0070382 exocytic vesicle;GO:0031045 dense core granule", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0050796 regulation of insulin secretion;GO:0016192 vesicle-mediated transport;GO:0031340 positive regulation of vesicle fusion;GO:0045956 positive regulation of calcium ion-dependent exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9R0N9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UFJ6-1", "uniprot_id": [ { "id": "T184A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UFJ6", "type": "external" } ], "mass": 46818.0, "length": 425, "protein_name": "Transmembrane protein 184A", "gene_name": "Tmem184a", "organism": "Mouse", "refseq_name": "transmembrane protein 184A isoform 1", "refseq_ac": [ { "id": "NP_001155020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155020", "type": "external" } ], "gene_names_uniprotkb": "Tmem184a; Sdmg1", "gene_names_refseq": "Sdmg1; Tmem184a", "protein_names_uniprotkb": "Transmembrane protein 184A; Sexually dimorphic expressed in male gonads 1", "protein_names_refseq": "sexually dimorphic expressed in male gonads 1; transmembrane protein 184A isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:231832)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;17616727;18321981;19097053;21750661;30084848", "class_list": "", "function": "Acts as a heparin receptor in vascular cells (By similarity). May be involved in vesicle transport in exocrine cells and Sertoli cells (PubMed:18321981, PubMed:19097053)., [UniProtKB, UniProtKB, PubMed, PubMed]; Identified a conserved transmembrane protein, Sdmg1, owing to its male-specific expression in embryonic gonads, [RefSeq, PubMed]; These data suggest that Sdmg1 is a component of regulated secretory granules in exocrine secretory cells and that the developmental regulation of Sdmg1 expression is related to a role for Sdmg1 in post-Golgi membrane trafficking., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BII8;Q8K1B0", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0030658 transport vesicle membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0032880 regulation of protein localization;GO:0051046 regulation of secretion;GO:0018992 germ-line sex determination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3UFJ6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88935-2", "uniprot_id": [ { "id": "SYN1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88935", "type": "external" } ], "mass": 74097.0, "length": 706, "protein_name": "Synapsin-1", "gene_name": "Syn1", "organism": "Mouse", "refseq_name": "synapsin-1 isoform b", "refseq_ac": [ { "id": "NP_001104250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104250", "type": "external" } ], "gene_names_uniprotkb": "Syn1; Syn-1", "gene_names_refseq": "Syn-1; Syn1-S; Syn1", "protein_names_uniprotkb": "Synapsin-1; Synapsin I", "protein_names_refseq": "synapsin-1 isoform b; synapsin-1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); non-syndromic X-linked intellectual disability 50 (Disease Ontology:DOID:0112029); X-linked epilepsy with variable learning disabilities and behavior disorders (Disease Ontology:DOID:0112122); major depressive disorder (Disease Ontology:DOID:1470)", "pathway": " (mmu:20964); (R-MMU-181429); (R-MMU-212676)", "pathway_count": 3, "publication_count": 29, "publication_id_list": "11571277;15345747;16452087;16452088;18034455;21183079;22517741;22645316;22826440;23807304;24081492;24129315;24280219;25428506;26192747;26495903;28657654;29078407;32782141;32848054;34318818;34678516;35822049;35908196;40021952;40885482;7568107;8034599;9890964", "class_list": "", "function": "Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (By similarity). Also involved in the regulation of axon outgrowth and synaptogenesis (PubMed:7568107). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxide functions at a presynaptic level (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 10, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 39, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 39, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 39, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 42, "binding_glycan_count": 0, "secondary_ac_list": "Q62279;Q8QZT8", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding", "go_cellular_component": "GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0060203 clathrin-sculpted glutamate transport vesicle membrane;GO:0005794 Golgi apparatus;GO:0005856 cytoskeleton;GO:0014069 postsynaptic density", "go_biological_process": "GO:0097091 synaptic vesicle clustering;GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0099504 synaptic vesicle cycle;GO:0050808 synapse organization;GO:0007269 neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 7.0, "record_id": "O88935-2", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100010001001.111.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64332-1", "uniprot_id": [ { "id": "SYN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64332", "type": "external" } ], "mass": 63373.0, "length": 586, "protein_name": "Synapsin-2", "gene_name": "Syn2", "organism": "Mouse", "refseq_name": "synapsin-2 isoform IIa", "refseq_ac": [ { "id": "NP_001104485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104485", "type": "external" } ], "gene_names_uniprotkb": "Syn2", "gene_names_refseq": "2900074L19Rik; Syn2", "protein_names_uniprotkb": "Synapsin-2; Synapsin II", "protein_names_refseq": "synapsin-2 isoform IIa; synapsin-2", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); epilepsy (Disease Ontology:DOID:1826); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:20965); (R-MMU-181429); (R-MMU-212676)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;21183079;22517741;22645316;22673524;32848054;33300544;34678516;35822049;40021952;40684658;40885482;8034599", "class_list": "", "function": "Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 20, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 20, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 20, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 22, "binding_glycan_count": 0, "secondary_ac_list": "Q6NZR0;Q9QWV7", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043209 myelin sheath", "go_biological_process": "GO:0097091 synaptic vesicle clustering;GO:0099504 synaptic vesicle cycle;GO:0050808 synapse organization;GO:0007269 neurotransmitter secretion;GO:0017156 calcium-ion regulated exocytosis", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q64332-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZWR6-1", "uniprot_id": [ { "id": "SYNE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZWR6", "type": "external" } ], "mass": 1009926.0, "length": 8799, "protein_name": "Nesprin-1", "gene_name": "Syne1", "organism": "Mouse", "refseq_name": "nesprin-1 isoform 3", "refseq_ac": [ { "id": "NP_001073154", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073154", "type": "external" } ], "gene_names_uniprotkb": "Syne1", "gene_names_refseq": "8B; A330049M09Rik; C130039F11Rik; CPG2; KASH1; Myne1; Syne1; mKIAA1756; myne-1", "protein_names_uniprotkb": "Nesprin-1; Enaptin; KASH domain-containing protein 1; KASH1; Myne-1; Myocyte nuclear envelope protein 1; Nuclear envelope spectrin repeat protein 1; Synaptic nuclear envelope protein 1; Syne-1", "protein_names_refseq": "KASH domain-containing protein 1; enaptin165; enaptin; myocyte nuclear envelope protein 1; nesprin 1; nesprin-1 isoform 3; nuclear envelope spectrin repeat protein 1; synaptic nuclear envelope 1; synaptic nuclear envelope protein 1", "tax_id": 10090, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); autosomal dominant Emery-Dreifuss muscular dystrophy 4 (Disease Ontology:DOID:0070249); arthrogryposis multiplex congenita (Disease Ontology:DOID:0080954); arthrogryposis multiplex congenita-3 (Disease Ontology:DOID:0080979); autosomal recessive spinocerebellar ataxia 8 (Disease Ontology:DOID:0111618); Emery-Dreifuss muscular dystrophy (Disease Ontology:DOID:11726); bipolar disorder (Disease Ontology:DOID:3312); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:64009)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;10878022;12958361;15093733;16452087;19509342;19596800;19874786;21183079;21750661;22518138;22872234;25428506;26621829;30899004;31219806;31616917;34203471;34418053;34428180;35820727;36210013;40885482", "class_list": "", "function": "Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 seem to act redundantly in cerebellum, midbrain, brain stem, and other brain regions except cerebral cortex and hippocampus. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 8, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q8K3T7;Q9ERT7;Q9ERT8", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:2001054 negative regulation of mesenchymal cell apoptotic process;GO:0090292 nuclear matrix anchoring at nuclear membrane;GO:0007283 spermatogenesis;GO:0048814 regulation of dendrite morphogenesis;GO:0048260 positive regulation of receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q6ZWR6-1", "record_type": "protein", "filter_code": "0000000.1000111.000010.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0N4-1", "uniprot_id": [ { "id": "SYT10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0N4", "type": "external" } ], "mass": 59019.0, "length": 523, "protein_name": "Synaptotagmin-10", "gene_name": "Syt10", "organism": "Mouse", "refseq_name": "synaptotagmin-10", "refseq_ac": [ { "id": "NP_061273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061273", "type": "external" } ], "gene_names_uniprotkb": "Syt10", "gene_names_refseq": "Syt10", "protein_names_uniprotkb": "Synaptotagmin-10; Synaptotagmin X; SytX", "protein_names_refseq": "synaptotagmin-10; sytX", "tax_id": 10090, "disease": "", "pathway": " (mmu:54526)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10531343;10531344;10871604;21183079;21496647;23345244", "class_list": "", "function": "Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb (PubMed:21496647). Exocytosis of IGF1 is required for sensory perception of smell (PubMed:21496647). Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (PubMed:21496647). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity)., [UniProtKB, PubMed, UniProtKB]; Study shows that olfactory bulb neurons secrete IGF-1 by an activity-dependent pathway of exocytosis, and that Syt10 functions as the Ca(2+)-sensor that triggers IGF-1 exocytosis in these neurons. GeneRIF: Syt10 knockout mice imply that Syt10 protein acts to trigger insulin-like growth factor 1 (IGF-1) secretion in the olfactory bulb, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030658 transport vesicle membrane;GO:0070382 exocytic vesicle;GO:0098793 presynapse", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0016192 vesicle-mediated transport;GO:0007608 sensory perception of smell;GO:0045956 positive regulation of calcium ion-dependent exocytosis;GO:0017158 regulation of calcium ion-dependent exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9R0N4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61264-1", "uniprot_id": [ { "id": "STX1B_MOUSE", "url": "https://www.uniprot.org/uniprot/P61264", "type": "external" } ], "mass": 33245.0, "length": 288, "protein_name": "Syntaxin-1B", "gene_name": "Stx1b", "organism": "Mouse", "refseq_name": "syntaxin-1B", "refseq_ac": [ { "id": "NP_077725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077725", "type": "external" } ], "gene_names_uniprotkb": "Stx1b; Stx1b1; Stx1b2", "gene_names_refseq": "Stx1b2; Stx1bl; Stx1b; Syn1b", "protein_names_uniprotkb": "Syntaxin-1B", "protein_names_refseq": "syntaxin 1B1; syntaxin 1B2; syntaxin-1B", "tax_id": 10090, "disease": "generalized epilepsy with febrile seizures plus 9 (Disease Ontology:DOID:0111301); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:56216); (R-MMU-5682910)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;15774481;16452087;17055430;21183079;21750661;33300544", "class_list": "", "function": "Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity). May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm., [UniProtKB, PubMed]; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2RSB4;O35525;P32853", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0006886 intracellular protein transport;GO:2000463 positive regulation of excitatory postsynaptic potential;GO:0010977 negative regulation of neuron projection development;GO:0016192 vesicle-mediated transport;GO:0072657 protein localization to membrane", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P61264-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08583-1", "uniprot_id": [ { "id": "THOC4_MOUSE", "url": "https://www.uniprot.org/uniprot/O08583", "type": "external" } ], "mass": 26940.0, "length": 255, "protein_name": "THO complex subunit 4", "gene_name": "Alyref", "organism": "Mouse", "refseq_name": "THO complex subunit 4", "refseq_ac": [ { "id": "NP_035698", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035698", "type": "external" } ], "gene_names_uniprotkb": "Alyref; Aly; Ref1; Refbp1; THOC4", "gene_names_refseq": "Alyref; Aly; Ref1-I; Ref1; Refbp1; Tho4; Thoc4", "protein_names_uniprotkb": "THO complex subunit 4; Ally of AML-1 and LEF-1; Aly/REF export factor; REF1-I; RNA and export factor-binding protein 1; Tho4; Transcriptional coactivator Aly/REF", "protein_names_refseq": "RNA and export factor binding protein 1; THO complex 4; THO complex subunit 4; Tcra enhancer-binding factor interacting protein 1; ally of AML-1 and LEF-1; transcriptional coactivator Aly/REF", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:21681); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-72163); (R-MMU-72187)", "pathway_count": 7, "publication_count": 12, "publication_id_list": "10786854;11158589;12809490;17322886;23806337;24129315;24463520;25605945;34428180;37640449;8746565;9119228", "class_list": "", "function": "Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway) (PubMed:10786854, PubMed:11158589, PubMed:9119228). Functions as an mRNA export adapter; component of the transcription/export (TREX) complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Plays a key role in mRNP recognition and mRNA packaging by bridging the mRNP-bound EJC and the TREX core complex. TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in mRNA export of C5-methylcytosine (m5C)-containing mRNAs: specifically recognizes and binds m5C mRNAs and mediates their nucleo-cytoplasmic shuttling. Acts as a chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation. Involved in transcription elongation and genome stability (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Incomplete activation of Alyref and Gabpb1 leads to preimplantation arrest in cloned mouse embryos. Publication Status: Online-Only, [RefSeq, PubMed]; Structure of the nuclear factor ALY provides insights into post-transcriptional regulatory and mRNA nuclear export processes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0VBL5;Q8CBM4;Q9JJW7", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003697 single-stranded DNA binding;GO:0062153 C5-methylcytidine-containing RNA reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0071013 catalytic step 2 spliceosome;GO:0000346 transcription export complex", "go_biological_process": "GO:0016071 mRNA metabolic process;GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0008380 RNA splicing;GO:0006405 RNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O08583-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23949-1", "uniprot_id": [ { "id": "TISD_MOUSE", "url": "https://www.uniprot.org/uniprot/P23949", "type": "external" } ], "mass": 50070.0, "length": 484, "protein_name": "mRNA decay activator protein ZFP36L2", "gene_name": "Zfp36l2", "organism": "Mouse", "refseq_name": "mRNA decay activator protein ZFP36L2", "refseq_ac": [ { "id": "NP_001001806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001806", "type": "external" } ], "gene_names_uniprotkb": "Zfp36l2; Tis11d", "gene_names_refseq": "Brf2; ERF2; Tis11d; Zfp36l2", "protein_names_uniprotkb": "mRNA decay activator protein ZFP36L2; Butyrate response factor 2; TPA-induced sequence 11d; ZFP36-like 2; Zinc finger protein 36, C3H1 type-like 2", "protein_names_refseq": "TPA-induced sequence 11d; ZFP36-like 2; butyrate response factor 2; mRNA decay activator protein ZFP36L2; zinc finger protein 36, C3H1 type-like 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:12193)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "11796723;15342461;19633199;1996120;20622884;22367205;22701344;23046558;23748442;24733888;24830504;25428506;25505318;25815583;27102483;28135057;31219806;34428180;37828378;38604490", "class_list": "", "function": "Zinc finger protein 36 like 2-histone deacetylase 1 axis is involved in the bone responses to mechanical stress., [RefSeq, PubMed]; Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:22367205, PubMed:22701344, PubMed:24830504, PubMed:25505318, PubMed:27102483). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (By similarity). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:22367205, PubMed:22701344, PubMed:24830504, PubMed:25505318). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (By similarity). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (PubMed:22701344). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA (PubMed:25505318). Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA (PubMed:24830504). Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation (PubMed:19633199, PubMed:23748442). In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation (PubMed:27102483). Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (PubMed:20622884)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EIF6;Q3TCE3;Q3TU59", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0008270 zinc ion binding;GO:0035925 mRNA 3'-UTR AU-rich region binding;GO:0160134 protein-RNA sequence-specific adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0045577 regulation of B cell differentiation;GO:0000165 MAPK cascade;GO:0043488 regulation of mRNA stability;GO:0009611 response to wounding;GO:0070371 ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P23949-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K467-1", "uniprot_id": [ { "id": "TMIE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K467", "type": "external" } ], "mass": 17027.0, "length": 153, "protein_name": "Transmembrane inner ear expressed protein", "gene_name": "Tmie", "organism": "Mouse", "refseq_name": "transmembrane inner ear expressed protein precursor", "refseq_ac": [ { "id": "NP_666372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666372", "type": "external" } ], "gene_names_uniprotkb": "Tmie", "gene_names_refseq": "5131400L21Rik; Mm.87012; Tmie; sr", "protein_names_uniprotkb": "Transmembrane inner ear expressed protein", "protein_names_refseq": "spinner; transmembrane inner ear expressed protein precursor; transmembrane inner ear expressed protein", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 6 (Disease Ontology:DOID:0110512); sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (mmu:20776)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12140191;17219777;36191207", "class_list": "", "function": "Auxiliary subunit of the mechanotransducer (MET) non-specific cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system (PubMed:36191207). The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15 (PubMed:36191207). May contribute to the formation of the pore (PubMed:36191207)., [UniProtKB, PubMed]; Characterized the circling mutation as a 40-kilobase deletion that includes the transmembrane inner ear (tmie) gene, [RefSeq, PubMed]; Mutation of the novel gene Tmie results in sensory cell defects in the inner ear of spinner, a mouse model of human hearing loss DFNB6., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0042472 inner ear morphogenesis;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K467-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BQ33-1", "uniprot_id": [ { "id": "TICRR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BQ33", "type": "external" } ], "mass": 208335.0, "length": 1889, "protein_name": "Treslin", "gene_name": "Ticrr", "organism": "Mouse", "refseq_name": "treslin", "refseq_ac": [ { "id": "NP_084111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084111", "type": "external" } ], "gene_names_uniprotkb": "Ticrr", "gene_names_refseq": "5730590G19Rik; Lrrk1; Ticrr", "protein_names_uniprotkb": "Treslin; TopBP1-interacting checkpoint and replication regulator; TopBP1-interacting, replication-stimulating protein", "protein_names_refseq": "leucine-rich repeat kinase 1; topBP1-interacting, replication-stimulating protein; treslin", "tax_id": 10090, "disease": "", "pathway": " (mmu:77011); (R-MMU-69273)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "19144319;21183079;21750661;25428506;30084848", "class_list": "", "function": "Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RY55;Q8C9N4;Q8CCI2", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0010212 response to ionizing radiation;GO:0007095 mitotic G2 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BQ33-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AI08-1", "uniprot_id": [ { "id": "TPRN_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AI08", "type": "external" } ], "mass": 80089.0, "length": 749, "protein_name": "Taperin", "gene_name": "Tprn", "organism": "Mouse", "refseq_name": "taperin", "refseq_ac": [ { "id": "NP_780495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780495", "type": "external" } ], "gene_names_uniprotkb": "Tprn", "gene_names_refseq": "C430004E15Rik; Tprn", "protein_names_uniprotkb": "Taperin", "protein_names_refseq": "taperin", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 79 (Disease Ontology:DOID:0110526)", "pathway": " (mmu:97031)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;19144319;20170898;20170899;21183079;24285636;27693694;30159668;30380417;31219806;32782141;35752427;37952086", "class_list": "", "function": "Critical role of TPRN rings in the stereocilia for hearing. Erratum:[Mol Ther. 2025 Jan 8;33(1):419-420. doi: 10.1016/j.ymthe.2024.12.004. PMID: 39672160], [RefSeq, PubMed]; Essential for hearing (PubMed:30380417, PubMed:35752427, PubMed:37952086). Required for maintenance of stereocilia on both inner and outer hair cells (PubMed:27693694). Necessary for the integrity of the stereociliary rootlet (PubMed:30159668). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (PubMed:30380417). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (PubMed:37952086). Acts as a strong inhibitor of PPP1CA phosphatase activity (By similarity). Recruited to sites of DNA damage and may play a role in DNA damage repair (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Reducing Taperin Expression Restores Hearing in Grxcr2 Mutant Mice., [RefSeq, PubMed]; Stereocilia lacking GRXCR2 are longer than normal and disorganized due to the mislocalization of taperin, which could modulate the actin cytoskeleton in stereocilia., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAJ8;Q3TMR8;Q5FWB3;Q7TNG3;Q8BNM5;Q8R1G4", "ec_number_list": [], "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity;GO:0003779 actin binding;GO:0008157 protein phosphatase 1 binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005902 microvillus;GO:0032420 stereocilium", "go_biological_process": "GO:0007605 sensory perception of sound;GO:0060088 auditory receptor cell stereocilium organization;GO:0120045 stereocilium maintenance", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "A2AI08-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6ZDS4-1", "uniprot_id": [ { "id": "TPR_MOUSE", "url": "https://www.uniprot.org/uniprot/F6ZDS4", "type": "external" } ], "mass": 273990.0, "length": 2431, "protein_name": "Nucleoprotein TPR", "gene_name": "Tpr", "organism": "Mouse", "refseq_name": "nucleoprotein TPR", "refseq_ac": [ { "id": "NP_598541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598541", "type": "external" } ], "gene_names_uniprotkb": "Tpr", "gene_names_refseq": "2610029M07Rik; Tpr", "protein_names_uniprotkb": "Nucleoprotein TPR; NPC-associated intranuclear protein; Translocated promoter region and nuclear basket protein", "protein_names_refseq": "NPC-associated intranuclear protein; nuclear pore complex-associated protein Tpr; nucleoprotein TPR; translocated promoter region and nuclear basket protein", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (mmu:108989); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885)", "pathway_count": 18, "publication_count": 20, "publication_id_list": "12424524;12513910;17242355;17525332;19131326;19144319;21183079;21750661;23806337;24129315;25428506;25605945;30779550;31219806;34203471;34428180;36210013;36852467;40021952;40885482", "class_list": "", "function": "Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Plays a limited role in the regulation of nuclear protein export. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q8R4A0;Q921B9", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003729 mRNA binding;GO:0042803 protein homodimerization activity;GO:0031072 heat shock protein binding;GO:0051019 mitogen-activated protein kinase binding", "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005737 cytoplasm", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0046832 negative regulation of RNA export from nucleus;GO:0035457 cellular response to interferon-alpha;GO:0006999 nuclear pore organization;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "F6ZDS4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UU67-1", "uniprot_id": [ { "id": "TRAT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UU67", "type": "external" } ], "mass": 21330.0, "length": 187, "protein_name": "T-cell receptor-associated transmembrane adapter 1", "gene_name": "Trat1", "organism": "Mouse", "refseq_name": "T-cell receptor-associated transmembrane adapter 1", "refseq_ac": [ { "id": "NP_938039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_938039", "type": "external" } ], "gene_names_uniprotkb": "Trat1", "gene_names_refseq": "C030046M14Rik; Tcrim; Trat1; Trim", "protein_names_uniprotkb": "T-cell receptor-associated transmembrane adapter 1; T-cell receptor-interacting molecule; TRIM", "protein_names_refseq": "T-cell receptor-associated transmembrane adapter 1; T-cell receptor-interacting molecule", "tax_id": 10090, "disease": "", "pathway": " (mmu:77647); (R-MMU-1257604); (R-MMU-202424); (R-MMU-6811558)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "11439161;16612002;18941181;21183079;21750661", "class_list": "", "function": "Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells., [UniProtKB]; TRIM and Src homology domain-containing tyrosine phosphatase 2-interacting transmembrane adaptor protein (SIT) regulate cell fate of developing thymocytes and are essential regulators of central tolerance., [RefSeq, PubMed]; TRIM is dispensable for T-cell development and peripheral immune functions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SXD9;Q3SXE0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042101 T cell receptor complex;GO:0034451 centriolar satellite;GO:0072686 mitotic spindle", "go_biological_process": "GO:0050850 positive regulation of calcium-mediated signaling;GO:0050862 positive regulation of T cell receptor signaling pathway;GO:0002250 adaptive immune response;GO:0001920 negative regulation of receptor recycling;GO:0051051 negative regulation of transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3UU67-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UHF7-1", "uniprot_id": [ { "id": "ZEP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UHF7", "type": "external" } ], "mass": 266705.0, "length": 2430, "protein_name": "Transcription factor HIVEP2", "gene_name": "Hivep2", "organism": "Mouse", "refseq_name": "transcription factor HIVEP2", "refseq_ac": [ { "id": "NP_034567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034567", "type": "external" } ], "gene_names_uniprotkb": "Hivep2; Mibp1", "gene_names_refseq": "Gm20114; Hivep2; MIBP-1; MIBP1; Schnurri-2; Shn-2", "protein_names_uniprotkb": "Transcription factor HIVEP2; Human immunodeficiency virus type I enhancer-binding protein 2 homolog; MIBP-1; Myc intron-binding protein 1", "protein_names_refseq": "human immunodeficiency virus type I enhancer-binding protein 2 homolog; myc intron-binding protein 1; transcription factor HIVEP2", "tax_id": 10090, "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787); autosomal dominant intellectual developmental disorder 43 (Disease Ontology:DOID:0070073); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); asthma (Disease Ontology:DOID:2841); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:15273)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10207097;15699073;16836985;19458039;21183079;21750661;21952136;22517741;22645316;25428506;25605945;30084848;30285890;30779550;31219806;32782141;32848054;34203471;34428180;34678516;35218885;35822049;40021952;40885482;40997131", "class_list": "", "function": "Data suggest that Schnurri-2 plays a crucial role in the control of T helper type 2 cell differentiation by regulating NF-kappaB function., [RefSeq, PubMed]; Schnurri-2 Promotes the Expression of Excitatory Glutamate Receptors and Contributes to Neuropathic Pain., [RefSeq, PubMed]; Shn-2 plays a critical role in locomotion and anxiety-like behavior. Stress-induced corticosterone levels were significantly higher in Shn-2(-/-) mice compared to wild-type controls., [RefSeq, PubMed]; Specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation (By similarity)., [UniProtKB, PubMed]; The Shn2 deficiency attenuates bidirectional short-term synaptic plasticity at the medial perforant path-granule cell synapse. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 46, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 46, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 46, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 48, "binding_glycan_count": 0, "secondary_ac_list": "O55140;Q3UVD4;Q3UVH5", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007165 signal transduction;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 7.3, "record_id": "Q3UHF7-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04736-1", "uniprot_id": [ { "id": "YES_MOUSE", "url": "https://www.uniprot.org/uniprot/Q04736", "type": "external" } ], "mass": 60630.0, "length": 541, "protein_name": "Tyrosine-protein kinase Yes", "gene_name": "Yes1", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase Yes", "refseq_ac": [ { "id": "NP_001192061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192061", "type": "external" } ], "gene_names_uniprotkb": "Yes1; Yes", "gene_names_refseq": "Yes1; Yes; p61-Yes", "protein_names_uniprotkb": "Tyrosine-protein kinase Yes; 2.7.10.2; Proto-oncogene c-Yes; p61-Yes", "protein_names_refseq": "Yamaguchi sarcoma viral (v-yes) oncogene homolog 1; proto-oncogene c-Yes; proto-oncogene tyrosine-protein kinase Yes; tyrosine-protein kinase Yes; viral oncogene yes homolog", "tax_id": 10090, "disease": "intestinal cancer (Disease Ontology:DOID:10155); Goldenhar syndrome (Disease Ontology:DOID:2907); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:22612); (R-MMU-1227986); (R-MMU-1433557); (R-MMU-1433559); (R-MMU-2029481); (R-MMU-210990); (R-MMU-389356); (R-MMU-389513); (R-MMU-3928662); (R-MMU-3928663); (R-MMU-3928665); (R-MMU-912631)", "pathway_count": 12, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;18034455;21750661;22645316;26979622;32804340;34006931;34105991;34428180;34678516;37828378;7681396;7958873;8206383;8437854;9058199", "class_list": "", "function": "AAV-mediated YAP expression in cardiac fibroblasts promotes inflammation and increases fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; Cold-induced Yes-associated-protein expression through miR-429 mediates the browning of white adipose tissue., [RefSeq, PubMed]; Differential effects of the Src family tyrosine kinases Yes and Fyn on lipopolysaccharide-induced lung injury in ice. Erratum:[Am J Physiol Lung Cell Mol Physiol. 2021 Nov 1;321(5):L988. doi: 10.1152/ajplung.00181.2020_COR. PMID: 34748448], [RefSeq, PubMed]; Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis (By similarity). Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005884 actin filament", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071300 cellular response to retinoic acid;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q04736-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIM5-1", "uniprot_id": [ { "id": "YIPF7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIM5", "type": "external" } ], "mass": 27490.0, "length": 254, "protein_name": "Protein YIPF7", "gene_name": "Yipf7", "organism": "Mouse", "refseq_name": "protein YIPF7", "refseq_ac": [ { "id": "NP_076273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076273", "type": "external" } ], "gene_names_uniprotkb": "Yipf7; Yip1b", "gene_names_refseq": "2310016N21Rik; Yip1b; Yipf7", "protein_names_uniprotkb": "Protein YIPF7; YIP1 family member 7", "protein_names_refseq": "protein YIPF7", "tax_id": 10090, "disease": "azoospermia (Disease Ontology:DOID:14227)", "pathway": " (mmu:75581)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11489904;21750661;25208654", "class_list": "", "function": "The following skeletal muscle development, the expression of the Yip1A decreases and is replaced by the muscle-specific Yip1B isoform., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005801 cis-Golgi network;GO:0005802 trans-Golgi network;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment;GO:0005737 cytoplasm", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization;GO:0048280 vesicle fusion with Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JIM5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62960-1", "uniprot_id": [ { "id": "YBOX1_MOUSE", "url": "https://www.uniprot.org/uniprot/P62960", "type": "external" } ], "mass": 35730.0, "length": 322, "protein_name": "Y-box-binding protein 1", "gene_name": "Ybx1", "organism": "Mouse", "refseq_name": "Y-box-binding protein 1", "refseq_ac": [ { "id": "NP_035862", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035862", "type": "external" } ], "gene_names_uniprotkb": "Ybx1; Msy-1; Msy1; Nsep1; Yb1", "gene_names_refseq": "1700102N10Rik; EF1A; MSY1; Nsep1; YB-1; Ybx1; dbpB; mYB-1a", "protein_names_uniprotkb": "Y-box-binding protein 1; CBF-A; CCAAT-binding transcription factor I subunit A; DBPB; DNA-binding protein B; EFI-A; Enhancer factor I subunit A; Nuclease-sensitive element-binding protein 1; Y-box transcription factor; YB-1", "protein_names_refseq": "CBF-A; CCAAT-binding transcription factor I subunit A; DNA-binding protein B; EFI-A; Y-box transcription factor; Y-box-binding protein 1; enhancer factor I subunit A; nuclease-sensitive element-binding protein 1", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:22608); (R-MMU-72163); (R-MMU-72165); (R-MMU-72203); (R-MMU-877300); (R-MMU-9017802); (R-MMU-9770562)", "pathway_count": 7, "publication_count": 26, "publication_id_list": "10318844;11162447;15345747;15899865;1622927;17242355;17322886;1741293;19131326;19470752;20665223;20713358;21183079;21750661;27064749;28784777;29712925;31219806;31387591;33725478;34887587;36288343;37453647;37828378;39927985;8505341", "class_list": "", "function": "DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:29712925, PubMed:8505341). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (By similarity). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (By similarity). Component of the CRD-mediated complex that promotes MYC mRNA stability (By similarity). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (By similarity). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (By similarity). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (By similarity). Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (PubMed:20713358). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (By similarity). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (By similarity). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (By similarity). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (By similarity). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P22568;P27817;P43482", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003676 nucleic acid binding;GO:0051020 GTPase binding", "go_cellular_component": "GO:0071204 histone pre-mRNA 3'end processing complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:1903608 protein localization to cytoplasmic stress granule;GO:0070934 CRD-mediated mRNA stabilization;GO:2000767 positive regulation of cytoplasmic translation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P62960-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46938-1", "uniprot_id": [ { "id": "YAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P46938", "type": "external" } ], "mass": 52383.0, "length": 488, "protein_name": "Transcriptional coactivator YAP1", "gene_name": "Yap1", "organism": "Mouse", "refseq_name": "transcriptional coactivator YAP1 isoform 1", "refseq_ac": [ { "id": "NP_001164618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164618", "type": "external" } ], "gene_names_uniprotkb": "Yap1; Yap65; Yap", "gene_names_refseq": "Yap1; Yap65; Yap; Yki; Yorkie", "protein_names_uniprotkb": "Transcriptional coactivator YAP1; Protein yorkie homolog; Yes-associated protein 1; Yes-associated protein YAP65 homolog", "protein_names_refseq": "65 kDa Yes-associated protein; Yes-associated protein isoform a474; Yes-associated protein isoform a475; Yes-associated protein isoform a476; Yes-associated protein isoform b309; Yes-associated protein isoform b313; Yes-associated protein isoform b325; protein yorkie homolog; transcriptional coactivator YAP1 isoform 1; transcriptional coactivator YAP1; yes-associated protein YAP65 homolog; yes-associated protein, 65 kDa; yorkie homolog", "tax_id": 10090, "disease": "cone dystrophy (Disease Ontology:DOID:0050795); uveal coloboma-cleft lip and palate-intellectual disability (Disease Ontology:DOID:0111249); intestinal cancer (Disease Ontology:DOID:10155); heart disease (Disease Ontology:DOID:114); coloboma (Disease Ontology:DOID:12270); neurodegenerative disease (Disease Ontology:DOID:1289); cancer (Disease Ontology:DOID:162); ovarian cancer (Disease Ontology:DOID:2394); carcinoma (Disease Ontology:DOID:305); nephrolithiasis (Disease Ontology:DOID:585); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:22601); (R-MMU-1251985); (R-MMU-2028269); (R-MMU-2032785); (R-MMU-8939236); (R-MMU-8951671); (R-MMU-9860927)", "pathway_count": 7, "publication_count": 30, "publication_id_list": "12807903;15345747;16461361;17242355;17525332;19131326;20123908;21145499;21183079;21205866;21750661;24462371;25601544;26985001;28087714;28124973;28474680;28492365;29340023;29400695;31599954;31723125;32782141;33630828;33725478;34428180;36852467;7644498;7782338;9407065", "class_list": "", "function": "This gene encodes a protein which binds to the SH3 domain of the Yes proto-oncogene product, a tyrosine kinase. This protein contains a WW domain, consisting of four conserved aromatic amino acids including two tryptophan residues. This conserved WW domain is found in various structural, regulatory and signaling molecules in various species, and may play a role in protein-protein interaction. Following cellular damage, phosphorylation of this encoded protein may suppress apoptosis. This protein may be involved in malignant transformation in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]., [RefSeq]; Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:29400695). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes. The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization. It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (By similarity). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:21145499). Synergizes with WBP2 to enhance PGR activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q52KJ5;Q91WL1", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0003714 transcription corepressor activity;GO:0070064 proline-rich region binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0061026 cardiac muscle tissue regeneration;GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation;GO:1902459 positive regulation of stem cell population maintenance;GO:1904036 negative regulation of epithelial cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P46938-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DU37-1", "uniprot_id": [ { "id": "ZFY26_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5DU37", "type": "external" } ], "mass": 282961.0, "length": 2529, "protein_name": "Zinc finger FYVE domain-containing protein 26", "gene_name": "Zfyve26", "organism": "Mouse", "refseq_name": "zinc finger FYVE domain-containing protein 26", "refseq_ac": [ { "id": "NP_001008550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008550", "type": "external" } ], "gene_names_uniprotkb": "Zfyve26; Kiaa0321", "gene_names_refseq": "4930465A13; 9330197E15Rik; A630028O16Rik; Gm893; Zfyve26; mKIAA0321", "protein_names_uniprotkb": "Zinc finger FYVE domain-containing protein 26", "protein_names_refseq": "zinc finger FYVE domain-containing protein 26", "tax_id": 10090, "disease": "hereditary spastic paraplegia 15 (Disease Ontology:DOID:0110768)", "pathway": " (mmu:211978)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21183079;21750661;24367272;31219806;34203471;34428180;36210013", "class_list": "", "function": "Increased levels of lysosomal enzymes in brains of aged knockout mice further support an alteration of the lysosomal compartment upon disruption of Zfyve26, [RefSeq, PubMed]; Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EJ71;Q3TEM9;Q3V1N3;Q8BY74;Q8CDR8;Q923B4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005813 centrosome;GO:0005764 lysosome;GO:0005770 late endosome;GO:0030496 midbody", "go_biological_process": "GO:0007040 lysosome organization;GO:0000281 mitotic cytokinesis;GO:0000724 double-strand break repair via homologous recombination;GO:1905037 autophagosome organization;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5DU37-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62511-1", "uniprot_id": [ { "id": "ZFP91_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62511", "type": "external" } ], "mass": 63389.0, "length": 572, "protein_name": "E3 ubiquitin-protein ligase ZFP91", "gene_name": "Zfp91", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase ZFP91", "refseq_ac": [ { "id": "NP_443735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443735", "type": "external" } ], "gene_names_uniprotkb": "Zfp91; Pzf", "gene_names_refseq": "9130014I08Rik; A530054C17Rik; Pzf; Zfp-91; Zfp91", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase ZFP91; 2.3.2.27; Penta Zf protein; RING-type E3 ubiquitin transferase ZFP91; Zfp-91; Zinc finger protein 91 homolog; Zinc finger protein PZF", "protein_names_refseq": "E3 ubiquitin-protein ligase ZFP91; RING-type E3 ubiquitin transferase ZFP91; penta Zf protein; zinc finger protein 91 homolog", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:109910)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17242355;20804734;21183079;22872234;25428506;31219806;34825365;7835706", "class_list": "", "function": "Convallatoxin inhibits IL-1beta production by suppressing zinc finger protein 91 (ZFP91)-mediated pro-IL-1beta ubiquitination and caspase-8 inflammasome activity., [RefSeq, PubMed]; DNA-binding transcription factor. Also acts as an atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis., [UniProtKB, UniProtKB]; Functional analysis of the human ZFP91 protein., [RefSeq, PubMed]; The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. The homologous human protein has been shown to function as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. A read-through transcript variant composed of Zfp91 and the downstream Cntf gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of Zfp91 and Cntf has been observed in both human and mouse. A Zfp91-related pseudogene has also been identified on chromosome 17. [provided by RefSeq, Oct 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEQ3;Q3UH61;Q62509;Q6P219;Q6PG06;Q8BPY3;Q8C2B4;Q8CDZ3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0070534 protein K63-linked ubiquitination;GO:0007250 activation of NF-kappaB-inducing kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q62511-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6KAQ7-1", "uniprot_id": [ { "id": "ZZZ3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6KAQ7", "type": "external" } ], "mass": 102307.0, "length": 910, "protein_name": "ZZ-type zinc finger-containing protein 3", "gene_name": "Zzz3", "organism": "Mouse", "refseq_name": "ZZ-type zinc finger-containing protein 3 isoform a", "refseq_ac": [ { "id": "NP_001074224", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074224", "type": "external" } ], "gene_names_uniprotkb": "Zzz3", "gene_names_refseq": "3110065C23Rik; 6430567E01Rik; Zzz3", "protein_names_uniprotkb": "ZZ-type zinc finger-containing protein 3", "protein_names_refseq": "ZZ-type zinc finger-containing protein 3 isoform a; ZZ-type zinc finger-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:108946); (R-MMU-9772755)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "21750661;23806337;31219806;34203471;34418053;34428180;34887587;36210013;40885482", "class_list": "", "function": "Histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation (By similarity). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMK6;Q3V189", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0072686 mitotic spindle;GO:0140672 ATAC complex", "go_biological_process": "GO:0090043 regulation of tubulin deacetylation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q6KAQ7-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PIU9-1", "uniprot_id": [ { "id": "YJ005_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PIU9", "type": "external" } ], "mass": 37705.0, "length": 354, "protein_name": "Uncharacterized protein FLJ45252 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein FLJ45252 homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "17242355;19144319;21183079;23806337;32782141", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BPJ9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6PIU9-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BG89-1", "uniprot_id": [ { "id": "ZN365_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BG89", "type": "external" } ], "mass": 46860.0, "length": 408, "protein_name": "Protein ZNF365", "gene_name": "Znf365", "organism": "Mouse", "refseq_name": "protein ZNF365", "refseq_ac": [ { "id": "NP_848794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848794", "type": "external" } ], "gene_names_uniprotkb": "Znf365; Dbz; Kiaa0844; Zfp365", "gene_names_refseq": "DBZ; Su48; Zfp365; Znf365; talanin", "protein_names_uniprotkb": "Protein ZNF365; DISC1-binding zinc-finger protein; Su48", "protein_names_refseq": "DISC1-binding zinc-finger protein; protein ZNF365", "tax_id": 10090, "disease": "uric acid nephrolithiasis (Disease Ontology:DOID:580)", "pathway": " (mmu:216049)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15363853;16617106;21183079;23776040;23912123;23966166;24481677;25983680;36139424", "class_list": "", "function": "Contributes to genomic stability by preventing telomere dysfunction (PubMed:23776040). Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis (PubMed:23912123). Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth (PubMed:24481677). Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (PubMed:25983680). Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth. Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) by HR. Is required for recovery of stalled replication forks, and directly contributes to genomic stability. Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Lack of ZNF365 Drives Senescence and Exacerbates Experimental Lung Fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80TQ4;Q8BK39;Q8BXT2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005813 centrosome", "go_biological_process": "GO:0048714 positive regulation of oligodendrocyte differentiation;GO:0140059 dendrite arborization;GO:0010977 negative regulation of neuron projection development;GO:0000723 telomere maintenance;GO:0010975 regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BG89-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGK6-1", "uniprot_id": [ { "id": "YLAT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGK6", "type": "external" } ], "mass": 56771.0, "length": 515, "protein_name": "Y+L amino acid transporter 2", "gene_name": "Slc7a6", "organism": "Mouse", "refseq_name": "Y+L amino acid transporter 2 isoform 1", "refseq_ac": [ { "id": "NP_848913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848913", "type": "external" } ], "gene_names_uniprotkb": "Slc7a6; Kiaa0245", "gene_names_refseq": "LAT-2; LAT3; Slc7a6; y+LAT-2", "protein_names_uniprotkb": "Y+L amino acid transporter 2; Solute carrier family 7 member 6; Y+LAT2; y(+)L-type amino acid transporter 2; y+LAT-2", "protein_names_refseq": "Y+L amino acid transporter 2 isoform 1; solute carriersolute carrier family 7 (cationic amino acid transporter, y+ system), member 6; y(+)L-type amino acid transporter 2; y+L amino acid transporter 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:330836); (R-MMU-210991); (R-MMU-352230)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10903140;19144319;19443642;21750661;24599290;25428506;25945809;30084848;31219806;37828378", "class_list": "", "function": "Both transcripts and protein of one y+L isoform, SLC7A6 (y+LAT2), are present in cumulus oocyte complexes, with little or no expression in isolated germinal vesicle (GV)-stage oocytes, MII eggs, or one-cell embryos. Publication Status: Online-Only, [RefSeq, PubMed]; Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis (By similarity). Also exchanges L-arginine with L-lysine in a sodium-independent manner (By similarity). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (By similarity). Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (By similarity). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells (By similarity). May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (PubMed:24599290)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; LAT3 may play a crucial role in the development and maintenance of podocyte structure and function by regulating protein synthesis and the actin cytoskeleton., [RefSeq, PubMed]; These data help to elucidate the molecular mechanisms and role of Lat2 in thyroid hormone transport., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMY5;Q3U084;Q6ZQF5;Q8CFY3", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0034618 arginine binding;GO:0015174 basic amino acid transmembrane transporter activity;GO:0061459 L-arginine transmembrane transporter activity;GO:0106439 L-lysine:L-arginine antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:1902495 transmembrane transporter complex", "go_biological_process": "GO:0015820 L-leucine transport;GO:0031460 glycine betaine transport;GO:0015804 neutral amino acid transport;GO:0006809 nitric oxide biosynthetic process;GO:0003333 amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BGK6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZ47-1", "uniprot_id": [ { "id": "ZN609_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZ47", "type": "external" } ], "mass": 151117.0, "length": 1413, "protein_name": "Zinc finger protein 609", "gene_name": "Zfp609; Znf609", "organism": "Mouse", "refseq_name": "zinc finger protein 609", "refseq_ac": [ { "id": "NP_766124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766124", "type": "external" } ], "gene_names_uniprotkb": "Zfp609; Znf609; Kiaa0295; Zfp609", "gene_names_refseq": "9830165N24; Zfp609; Znf609; mKIAA0295", "protein_names_uniprotkb": "Zinc finger protein 609", "protein_names_refseq": "zinc finger protein 609", "tax_id": 10090, "disease": "", "pathway": " (mmu:214812)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "17242355;21183079;21750661;23076336;25428506;25921068;28041881;28344082;30201567;34418053;34678516;35820727;38105235;40997131", "class_list": "", "function": "CircZNF609 regulates pulmonary fibrosis via miR-145-5p/KLF4 axis and its translation function. Publication Status: Online-Only, [RefSeq, PubMed]; Depletion of Zfp609 or Nipbl from cortical neural progenitors in vivo is detrimental to neuronal migration. Zfp609 and Nipbl overlap at genomic binding sites independently of cohesin and regulate genes that control cortical neuron migration., [RefSeq, PubMed]; Involved in regulation of myoblast proliferation during myogenesis., [UniProtKB, PubMed]; Transcription factor, which activates RAG1, and possibly RAG2, transcription (PubMed:23076336). Through the regulation of RAG1/2 expression, may regulate thymocyte maturation (PubMed:23076336). Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process (PubMed:28041881). Preferentially binds promoters containing paused RNA polymerase II (PubMed:28041881). Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (PubMed:28041881)., [UniProtKB, PubMed, PubMed]; Zfp609 circular RNA regulates myoblast differentiation by sponging miR-194-5p, [RefSeq, PubMed]; Zfp609 is necessary for Rag1 and Rag2 expression in developing thymocytes., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q05DD7;Q6PD47;Q6ZQE3", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0033089 positive regulation of T cell differentiation in thymus;GO:0007517 muscle organ development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8BZ47-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CIE2-1", "uniprot_id": [ { "id": "ZMIZ2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CIE2", "type": "external" } ], "mass": 96719.0, "length": 920, "protein_name": "Zinc finger MIZ domain-containing protein 2", "gene_name": "Zmiz2", "organism": "Mouse", "refseq_name": "zinc finger MIZ domain-containing protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001005867", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005867", "type": "external" } ], "gene_names_uniprotkb": "Zmiz2; D11Bwg0280e; Zimp7", "gene_names_refseq": "Zimp7; Zmiz2", "protein_names_uniprotkb": "Zinc finger MIZ domain-containing protein 2; PIAS-like protein Zimp7", "protein_names_refseq": "PIAS-like protein Zimp7; zinc finger MIZ domain-containing protein 2 isoform 2; zinc finger MIZ domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:52915)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19931425;20159969;24129315;24174533;40997131", "class_list": "", "function": "A novel interaction between ZMIZ2 and beta-caten, [RefSeq, PubMed]; Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors., [UniProtKB]; There is an interaction between Zimp7 and PIAS proteins with higher preference for PIAS3, in androgen receptor-mediated transcription, [RefSeq, PubMed]; Zimp7 is expressed in germ cells of the embryonic gonad and the adult testis., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5SVX4;Q5SVX5;Q5SVX6;Q6P558;Q6P9Q5;Q8BJ00", "ec_number_list": [], "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0000785 chromatin", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0016925 protein sumoylation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8CIE2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQQ2-1", "uniprot_id": [ { "id": "YIPF5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQQ2", "type": "external" } ], "mass": 27873.0, "length": 257, "protein_name": "Protein YIPF5", "gene_name": "Yipf5", "organism": "Mouse", "refseq_name": "protein YIPF5", "refseq_ac": [ { "id": "NP_075800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075800", "type": "external" } ], "gene_names_uniprotkb": "Yipf5; Yip1a", "gene_names_refseq": "2610311I19Rik; Yip1a; Yipf5", "protein_names_uniprotkb": "Protein YIPF5; YIP1 family member 5; YPT-interacting protein 1 A", "protein_names_refseq": "YIP1 family member 5; YPT-interacting protein 1 A; protein YIPF5", "tax_id": 10090, "disease": "azoospermia (Disease Ontology:DOID:14227)", "pathway": " (mmu:67180)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11489904;15254263;31219806", "class_list": "", "function": "Plays a role in transport between endoplasmic reticulum and Golgi. In pancreatic beta cells, required to transport proinsulin from endoplasmic reticulum into the Golgi., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0060628 regulation of ER to Golgi vesicle-mediated transport;GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization;GO:0048280 vesicle fusion with Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9EQQ2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKB3-1", "uniprot_id": [ { "id": "YBOX3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKB3", "type": "external" } ], "mass": 38814.0, "length": 361, "protein_name": "Y-box-binding protein 3", "gene_name": "Ybx3", "organism": "Mouse", "refseq_name": "Y-box-binding protein 3 short isoform", "refseq_ac": [ { "id": "NP_035863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035863", "type": "external" } ], "gene_names_uniprotkb": "Ybx3; Csda; Msy4", "gene_names_refseq": "Csda; Dpba; MSY3; MSY4; Yb2; Ybx3; dbpA; oxyR", "protein_names_uniprotkb": "Y-box-binding protein 3; Cold shock domain-containing protein A; DNA-binding protein A; Y-box protein 3", "protein_names_refseq": "DNA-binding protein A; Y-box-binding protein 3 short isoform; Y-box-binding protein 3; cold shock domain protein A; cold shock domain-containing protein A", "tax_id": 10090, "disease": "", "pathway": " (mmu:56449)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10772793;10956549;11564883;12117816;21183079;24129315;25428506;26146542;28315936;33725478;34428180;34887587;37408260;38159852;38821446;39032963;39927985", "class_list": "", "function": "Binds to the GM-CSF promoter. Seems to act as a repressor (By similarity). Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression., [UniProtKB, PubMed]; Cold Shock Domain Protein DbpA Orchestrates Tubular Cell Damage and Interstitial Fibrosis in Inflammatory Kidney Disease. Publication Status: Online-Only, [RefSeq, PubMed]; DNA-binding protein-A promotes kidney ischemia/reperfusion injury and participates in mitochondrial function., [RefSeq, PubMed]; DNA-binding protein-A: a multitool in tubular epithelial cells., [RefSeq, PubMed]; The YBX3 RNA-binding protein posttranscriptionally controls SLC1A5 mRNA in proliferating and differentiating skeletal muscle cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80WG4;Q9EQF7;Q9EQF8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0043021 ribonucleoprotein complex binding;GO:0003676 nucleic acid binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0005921 gap junction", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0009566 fertilization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9JKB3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UH66-1", "uniprot_id": [ { "id": "WNK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UH66", "type": "external" } ], "mass": 227527.0, "length": 2149, "protein_name": "Serine/threonine-protein kinase WNK2", "gene_name": "Wnk2", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase WNK2 isoform a", "refseq_ac": [ { "id": "NP_001277240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277240", "type": "external" } ], "gene_names_uniprotkb": "Wnk2; Kiaa1760", "gene_names_refseq": "1810073P09Rik; ESTM15; Wnk2; mKIAA1760", "protein_names_uniprotkb": "Serine/threonine-protein kinase WNK2; 2.7.11.1; Protein kinase lysine-deficient 2; Protein kinase with no lysine 2", "protein_names_refseq": "protein kinase lysine-deficient 2; protein kinase with no lysine 2; serine/threonine-protein kinase WNK2 isoform a; serine/threonine-protein kinase WNK2", "tax_id": 10090, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224); pseudohypoaldosteronism (Disease Ontology:DOID:4479)", "pathway": " (mmu:75607)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "21183079;21733846;21750661;22517741;22645316;22826440;24129315;30016717;32848054;33437477;34428180;34678516;40021952;40885482", "class_list": "", "function": "Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (By similarity). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (By similarity). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q3V387;Q6PAN9;Q6ZPI6;Q7TNS1;Q811F2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0008285 negative regulation of cell population proliferation;GO:0035556 intracellular signal transduction;GO:0046777 protein autophosphorylation;GO:0070373 negative regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q3UH66-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D684-1", "uniprot_id": [ { "id": "RIN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D684", "type": "external" } ], "mass": 101559.0, "length": 903, "protein_name": "Ras and Rab interactor 2", "gene_name": "Rin2", "organism": "Mouse", "refseq_name": "ras and Rab interactor 2 isoform 1", "refseq_ac": [ { "id": "NP_083000", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083000", "type": "external" } ], "gene_names_uniprotkb": "Rin2", "gene_names_refseq": "2010003K16Rik; 4632403N06Rik; RASSF4; Rin2", "protein_names_uniprotkb": "Ras and Rab interactor 2; Ras interaction/interference protein 2", "protein_names_refseq": "ras and Rab interactor 2 isoform 1; ras interaction/interference protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74030); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "19144319;21183079;21750661;31219806;34428180;35820727;37827343", "class_list": "", "function": "NAA20 recruits Rin2 and promotes triple-negative breast cancer progression by regulating Rab5A-mediated activation of EGFR signaling., [RefSeq, PubMed]; Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8Y5L0;Q3U6Z8;Q3UAK3;Q3UC54;Q99K06", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0030139 endocytic vesicle;GO:0005737 cytoplasm", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0010595 positive regulation of endothelial cell migration;GO:2001214 positive regulation of vasculogenesis;GO:1904906 positive regulation of endothelial cell-matrix adhesion via fibronectin", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D684-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59808-1", "uniprot_id": [ { "id": "SASH1_MOUSE", "url": "https://www.uniprot.org/uniprot/P59808", "type": "external" } ], "mass": 135591.0, "length": 1230, "protein_name": "SAM and SH3 domain-containing protein 1", "gene_name": "Sash1", "organism": "Mouse", "refseq_name": "SAM and SH3 domain-containing protein 1", "refseq_ac": [ { "id": "NP_780364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780364", "type": "external" } ], "gene_names_uniprotkb": "Sash1", "gene_names_refseq": "1100001C18Rik; 2500002E12Rik; A330076K04Rik; Sash1; mKIAA0790", "protein_names_uniprotkb": "SAM and SH3 domain-containing protein 1", "protein_names_refseq": "SAM and SH3 domain-containing protein 1; putative adapter and scaffold protein 1", "tax_id": 10090, "disease": "dyschromatosis universalis hereditaria (Disease Ontology:DOID:0060304)", "pathway": " (mmu:70097)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12771949;16137664;16452087;17242355;19144319;21183079;21750661;23776175;28528544;31067462", "class_list": "", "function": "Endothelial Sash1 regulates alveolar epithelial cell maturation and promotes pulmonary surfactant production through nitric oxide signaling., [RefSeq, PubMed]; Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Not expressed in the investigated haematopoietic cell lines, while transcripts were found in whole splenic B-cells from both wild type and Btk-defective mice., [RefSeq, PubMed]; SASH1 acts to assemble a signaling complex downstream of TLR4 to activate early endothelial responses to receptor activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0001965 G-protein alpha-subunit binding;GO:0031435 mitogen-activated protein kinase kinase kinase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0010595 positive regulation of endothelial cell migration;GO:0045766 positive regulation of angiogenesis;GO:1900745 positive regulation of p38MAPK cascade;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P59808-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDC0-1", "uniprot_id": [ { "id": "SYLM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDC0", "type": "external" } ], "mass": 101480.0, "length": 902, "protein_name": "Probable leucine--tRNA ligase, mitochondrial", "gene_name": "Lars2", "organism": "Mouse", "refseq_name": "probable leucine--tRNA ligase, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_001335096", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001335096", "type": "external" } ], "gene_names_uniprotkb": "Lars2", "gene_names_refseq": "Kiaa0028; LEURS; Lars2", "protein_names_uniprotkb": "Probable leucine--tRNA ligase, mitochondrial; 6.1.1.4; LeuRS; Leucyl-tRNA synthetase", "protein_names_refseq": "probable leucine--tRNA ligase, mitochondrial isoform 1; probable leucine--tRNA ligase, mitochondrial", "tax_id": 10090, "disease": "Perrault syndrome (Disease Ontology:DOID:0050857); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:102436)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12461651;21750661;23576753;25428506;30084848;35659337;37507081", "class_list": "", "function": "Leucine-tRNA-synthase-2-expressing B cells contribute to colorectal cancer immunoevasion. Erratum:[Immunity. 2022 Sep 13;55(9):1748. doi: 10.1016/j.immuni.2022.07.017. PMID: 36103860], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6H6S4", "ec_number_list": [ { "id": "6.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.4", "type": "external" } ], "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0004823 leucine-tRNA ligase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005737 cytoplasm", "go_biological_process": "GO:0006429 leucyl-tRNA aminoacylation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8VDC0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2H2-1", "uniprot_id": [ { "id": "RGS6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2H2", "type": "external" } ], "mass": 54531.0, "length": 472, "protein_name": "Regulator of G protein signaling 6", "gene_name": "Rgs6", "organism": "Mouse", "refseq_name": "regulator of G-protein signaling 6 isoform 2", "refseq_ac": [ { "id": "NP_001268990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268990", "type": "external" } ], "gene_names_uniprotkb": "Rgs6", "gene_names_refseq": "Rgs6", "protein_names_uniprotkb": "Regulator of G protein signaling 6; RGS6", "protein_names_refseq": "regulator of G-protein signaling 6 isoform 2", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:50779); (R-MMU-418594); (R-MMU-6814122)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;15632198;15897264;20616094;21750661;30059200;36929333;38066447;38332109;38409136", "class_list": "", "function": "A splice acceptor variant in RGS6 associated with intellectual disability, microcephaly, and cataracts disproportionately promotes expression of a subset of RGS6 isoforms., [RefSeq, PubMed]; RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21. Publication Status: Online-Only, [RefSeq, PubMed]; RGS6 negatively regulates inhibitory G protein signaling in dopamine neurons and positively regulates binge-like alcohol consumption in mice., [RefSeq, PubMed]; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity., [UniProtKB, UniProtKB]; Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Rgs16 and Rgs8 are likely to control aspects of islet progenitor cell activation, differentiation and beta-cell expansion in embryos and metabolically stressed adults., [RefSeq, PubMed]; This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP (Dishevelled, Egl-10, and Pleckstrin) and GGL (G-protein gamma like)domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Mice lacking this gene exhibit decreased heart rate. Alternative splicing results in multiple transcript variants, however, the full-length nature of some of these variants is not known. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q08AT5;Q8BGI8", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0043547 positive regulation of GTPase activity;GO:0045666 positive regulation of neuron differentiation;GO:0009968 negative regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9Z2H2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60695-1", "uniprot_id": [ { "id": "RGL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60695", "type": "external" } ], "mass": 86324.0, "length": 768, "protein_name": "Ral guanine nucleotide dissociation stimulator-like 1", "gene_name": "Rgl1", "organism": "Mouse", "refseq_name": "ral guanine nucleotide dissociation stimulator-like 1 isoform 1", "refseq_ac": [ { "id": "NP_001333046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333046", "type": "external" } ], "gene_names_uniprotkb": "Rgl1; Rgl", "gene_names_refseq": "Rgl1; Rgl; mKIAA0959", "protein_names_uniprotkb": "Ral guanine nucleotide dissociation stimulator-like 1; RalGDS-like 1", "protein_names_refseq": "ral guanine nucleotide dissociation stimulator-like 1 isoform 1; ralGDS-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:19731); (R-MMU-5673001)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "19144319;20173027;21183079;21750661;24887395;25428506;30084848;30779550;34428180;7935463;9891982", "class_list": "", "function": "Probable guanine nucleotide exchange factor., [UniProtKB]; Rgl1 expression was strongly reduced by COX-2 deletion across all examined tissues. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the Ras-like (Ral) -selective guanine nucleotide exchange factor (RalGEF) family of small GTPase activators which function both as downstream effectors of activated Ras GTPase and as regulators of certain Ral GTPases in the RalGEF - Ral GTPase signaling pathway. The encoded protein, like other RalGEFs, has an N-terminal ras exchanger motif domain, a catalytic CDC25 homology domain, and a C-terminal ras binding domain that stimulates guanine nucleotide exchange when bound to a Ral GTPase. RalGEF family members bridge the Ras and Ral signaling pathways and are thought to play a role in oncogenic transformation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VD09", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007265 Ras protein signal transduction;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q60695-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UH06-1", "uniprot_id": [ { "id": "RREB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UH06", "type": "external" } ], "mass": 184154.0, "length": 1700, "protein_name": "Ras-responsive element-binding protein 1", "gene_name": "Rreb1", "organism": "Mouse", "refseq_name": "ras-responsive element-binding protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001034277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034277", "type": "external" } ], "gene_names_uniprotkb": "Rreb1", "gene_names_refseq": "1110037N09Rik; B930013M22Rik; Rreb1; sao", "protein_names_uniprotkb": "Ras-responsive element-binding protein 1; RAS-responsive zinc finger transcription factor RREB; RREB-1", "protein_names_refseq": "RAS-responsive zinc finger transcription factor RREB; ras-responsive element-binding protein 1 isoform 1", "tax_id": 10090, "disease": "RASopathy (Disease Ontology:DOID:0080690)", "pathway": " (mmu:68750)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12700664;17242355;21183079;21750661;25605945;27923061;30084848;31219806;34428180;34678516;36852467;38198538;38248872;40997131", "class_list": "", "function": "RREB1 regulates neuronal proteostasis and the microtubule network., [RefSeq, PubMed]; Rreb1 is a key transcription factor in Sertoli cell maturation and function and spermatogenesis in mouse., [RefSeq, PubMed]; Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:12700664). Represses the angiotensinogen gene (By similarity). Negatively regulates the transcriptional activity of AR (By similarity). Potentiates the transcriptional activity of NEUROD1 (By similarity). Binds specifically to the allelic variant of the CDKN2A promoter present in Balb/c mice, which leads to a down-regulation of CDKN2A expression in this strain, and, as a consequence, to an elevated susceptibility to pristane-induced tumors (PubMed:12700664). Promotes brown adipocyte differentiation (PubMed:27923061). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "B8JJE2;B8JJE3;Q3TB97;Q4ZE88;Q66JZ8", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0001650 fibrillar center", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q3UH06-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCH6-1", "uniprot_id": [ { "id": "ZFAN6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCH6", "type": "external" } ], "mass": 24001.0, "length": 223, "protein_name": "AN1-type zinc finger protein 6", "gene_name": "Zfand6", "organism": "Mouse", "refseq_name": "AN1-type zinc finger protein 6 isoform a", "refseq_ac": [ { "id": "NP_075361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075361", "type": "external" } ], "gene_names_uniprotkb": "Zfand6; Awp1; Za20d3", "gene_names_refseq": "3110005P07Rik; Awp1; Za20d3; Zfand6", "protein_names_uniprotkb": "AN1-type zinc finger protein 6; Associated with PRK1 protein; Zinc finger A20 domain-containing protein 3", "protein_names_refseq": "AN1-type zinc finger protein 6 isoform a; AN1-type zinc finger protein 6; associated with PRK1 protein; associated with Prkcl1; zinc finger A20 domain-containing protein 3; zinc finger, A20 domain containing 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:65098); (R-MMU-9033241)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11054541;21750661;21980954;23806337;31219806", "class_list": "", "function": "AWP1 is a novel cofactor of Pex6 involved in the regulation of Pex5 export during peroxisome biogenesis., [RefSeq, PubMed]; Involved in regulation of TNF induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1 (By similarity). Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ER79", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0015031 protein transport;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0071356 cellular response to tumor necrosis factor;GO:0043122 regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DCH6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R205-1", "uniprot_id": [ { "id": "ZC3HA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R205", "type": "external" } ], "mass": 46121.0, "length": 435, "protein_name": "Zinc finger CCCH domain-containing protein 10", "gene_name": "Zc3h10", "organism": "Mouse", "refseq_name": "zinc finger CCCH domain-containing protein 10", "refseq_ac": [ { "id": "NP_598764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598764", "type": "external" } ], "gene_names_uniprotkb": "Zc3h10", "gene_names_refseq": "Zc3h10", "protein_names_uniprotkb": "Zinc finger CCCH domain-containing protein 10", "protein_names_refseq": "zinc finger CCCH domain-containing protein 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:103284)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21750661;24129315;29507079;31775033;33107819;33566069;34887587;37828378;40997131", "class_list": "", "function": "Dot1l interacts with Zc3h10 to activate Ucp1 and other thermogenic genes. Publication Status: Online-Only, [RefSeq, PubMed]; Our study identifies Zc3h10 as a novel mitochondrial regulator., [RefSeq, PubMed]; Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5'-GCAGCGC-3' on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Zc3h10 regulates adipogenesis by controlling translation and F-actin/mitochondria interaction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0035198 miRNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:1903799 negative regulation of miRNA processing;GO:0010608 post-transcriptional regulation of gene expression;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8R205-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924D0-1", "uniprot_id": [ { "id": "RT4I1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q924D0", "type": "external" } ], "mass": 43371.0, "length": 396, "protein_name": "NAD(P)H oxidoreductase RTN4IP1, mitochondrial", "gene_name": "Rtn4ip1", "organism": "Mouse", "refseq_name": "NAD(P)H oxidoreductase RTN4IP1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_570962", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570962", "type": "external" } ], "gene_names_uniprotkb": "Rtn4ip1; Nimp", "gene_names_refseq": "D10Ertd690e; NIMP; Rtn4ip1", "protein_names_uniprotkb": "NAD(P)H oxidoreductase RTN4IP1, mitochondrial; 1.6.5.-; NOGO-interacting mitochondrial protein; Reticulon-4-interacting protein 1", "protein_names_refseq": "NAD(P)H oxidoreductase RTN4IP1, mitochondrial precursor; NAD(P)H oxidoreductase RTN4IP1, mitochondrial; NOGO-interacting mitochondrial protein; reticulon-4-interacting protein 1, mitochondrial", "tax_id": 10090, "disease": "optic atrophy 10 (Disease Ontology:DOID:0111434)", "pathway": " (mmu:170728)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12067236;21750661;26593267;30084848;34418053;37507081;37884807", "class_list": "", "function": "Mitochondrial matrix RTN4IP1/OPA10 is an oxidoreductase for coenzyme Q synthesis., [RefSeq, PubMed]; NAD(P)H oxidoreductase involved in the ubiquinone biosynthetic pathway (PubMed:37884807). Required for the O-methyltransferase activity of COQ3 (By similarity). Able to catalyze the oxidoreduction of 3-demethylubiquinone into 3-demethylubiquinol in vitro (By similarity). However, it is unclear if 3-demethylubiquinone constitutes a substrate in vivo (By similarity). May also play a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve (PubMed:26593267). Appears to be a potent inhibitor of regeneration following spinal cord injury (PubMed:12067236)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; NAD(P)H oxidoreductase involved in the ubiquinone biosynthetic pathway. Required for the O-methyltransferase activity of COQ3. Able to catalyze the oxidoreduction of 3-demethylubiquinone into 3-demethylubiquinol in vitro. However, it is unclear if 3-demethylubiquinone constitutes a substrate in vivo. May also play a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1T0", "ec_number_list": [ { "id": "1.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0018455 alcohol dehydrogenase [NAD(P)+] activity;GO:0008270 zinc ion binding;GO:0000166 nucleotide binding;GO:0008753 NADPH dehydrogenase (quinone) activity;GO:0050136 NADH dehydrogenase (quinone) (non-electrogenic) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0007399 nervous system development;GO:0006744 ubiquinone biosynthetic process;GO:0050773 regulation of dendrite development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q924D0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CH09-1", "uniprot_id": [ { "id": "SUGP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CH09", "type": "external" } ], "mass": 118103.0, "length": 1067, "protein_name": "SURP and G-patch domain-containing protein 2", "gene_name": "Sugp2", "organism": "Mouse", "refseq_name": "SURP and G-patch domain-containing protein 2", "refseq_ac": [ { "id": "NP_001161762", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161762", "type": "external" } ], "gene_names_uniprotkb": "Sugp2; Sfrs14; Srsf14", "gene_names_refseq": "Sfrs14; Srsf14; Sugp2; mKIAA0365", "protein_names_uniprotkb": "SURP and G-patch domain-containing protein 2; Arginine/serine-rich-splicing factor 14; Splicing factor, arginine/serine-rich 14", "protein_names_refseq": "SURP and G-patch domain-containing protein 2; arginine/serine-rich-splicing factor 14; putative splicing factor, arginine/serine-rich 14; serine/arginine-rich splicing factor 14; splicing factor, arginine/serine-rich 14", "tax_id": 10090, "disease": "", "pathway": " (mmu:234373)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12594045;21183079;21750661;34428180;35820727", "class_list": "", "function": "May play a role in mRNA splicing., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6PG19;Q80UY8;Q8BY32;Q8CFM0", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8CH09-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42209-1", "uniprot_id": [ { "id": "SEPT1_MOUSE", "url": "https://www.uniprot.org/uniprot/P42209", "type": "external" } ], "mass": 42020.0, "length": 366, "protein_name": "Septin-1", "gene_name": "Septin1", "organism": "Mouse", "refseq_name": "septin-1", "refseq_ac": [ { "id": "NP_059489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059489", "type": "external" } ], "gene_names_uniprotkb": "Septin1; Diff6; Pnutl3; Sept1", "gene_names_refseq": "Diff6; Pnutl3; Sept1; Septin1", "protein_names_uniprotkb": "Septin-1; Differentiation protein 6; Peanut-like protein 3; Protein Diff6", "protein_names_refseq": "differentiation 6 (deoxyguanosine triphosphate triphosphohydrolase); differentiation protein 6; peanut-like protein 3; protein Diff6; septin-1", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:54204)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19043408;20173027;21183079;2174398;21750661;21932310;25428506;30084848;30779550;32146512", "class_list": "", "function": "Biochemical and morphological characterization of SEPT1 in mouse brain., [RefSeq, PubMed]; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)., [UniProtKB]; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis., [UniProtKB, UniProtKB]; Results show that septin1 is a key player in spindle assembly and chromosome congression in mouse meiosis., [RefSeq, PubMed]; These data suggest that septins tune actomyosin forces during motility and probably regulate lymphocyte trafficking in confined tissues., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RU74", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005940 septin ring;GO:0005813 centrosome;GO:0015630 microtubule cytoskeleton;GO:0030496 midbody;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis;GO:0017157 regulation of exocytosis;GO:0007056 spindle assembly involved in female meiosis;GO:0051311 meiotic metaphase chromosome alignment", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P42209-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D662-1", "uniprot_id": [ { "id": "SC23B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D662", "type": "external" } ], "mass": 86437.0, "length": 767, "protein_name": "Protein transport protein Sec23B", "gene_name": "Sec23b", "organism": "Mouse", "refseq_name": "protein transport protein Sec23B isoform 1", "refseq_ac": [ { "id": "NP_001239472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239472", "type": "external" } ], "gene_names_uniprotkb": "Sec23b", "gene_names_refseq": "Sec23b", "protein_names_uniprotkb": "Protein transport protein Sec23B; SEC23-related protein B", "protein_names_refseq": "SEC23-related protein B; protein transport protein Sec23B isoform 1; protein transport protein Sec23B", "tax_id": 10090, "disease": "craniolenticulosutural dysplasia (Disease Ontology:DOID:0070307); Cowden syndrome 7 (Disease Ontology:DOID:0081003); congenital dyserythropoietic anemia type II (Disease Ontology:DOID:0111401); Roberts syndrome (Disease Ontology:DOID:5325)", "pathway": " (mmu:27054)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;20173027;21750661;22745161;23806337;26495903;27297878;28539403;30065114;34887587;34954140;35820727;36210013;39627609", "class_list": "", "function": "A common human missense mutation of vesicle coat protein SEC23B leads to growth restriction and chronic pancreatitis in mice., [RefSeq, PubMed]; Acinar Sec23b deletion results in induction of ER stress and increased apoptosis in the pancreas, potentially explaining the loss of pancreatic cells and decreased pancreatic weight. These findings demonstrate that SEC23B is required for normal function of pancreatic acinar cells in adult mice., [RefSeq, PubMed]; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In SEC23B-deficient embryonic pancreas, defects occur in exocrine and endocrine tissues shortly after differentiation., [RefSeq, PubMed]; SEC23B but not SEC23A is essential for murine pancreatic development. Publication Status: Online-Only, [RefSeq, PubMed]; These data demonstrate an equivalent function for SEC23A/B, with evolutionary shifts in the transcription program likely accounting for the distinct phenotypes of SEC23A/B deficiency within and across species, a paradigm potentially applicable to other sets of paralogous genes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ANA1;Q3U6B3;Q99K49;Q9QZ68", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0015031 protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9D662-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97764-1", "uniprot_id": [ { "id": "WBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97764", "type": "external" } ], "mass": 33165.0, "length": 304, "protein_name": "WW domain-binding protein 1", "gene_name": "Wbp1", "organism": "Mouse", "refseq_name": "WW domain-binding protein 1 isoform 3", "refseq_ac": [ { "id": "NP_001077392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077392", "type": "external" } ], "gene_names_uniprotkb": "Wbp1", "gene_names_refseq": "Wbp1", "protein_names_uniprotkb": "WW domain-binding protein 1; WBP-1", "protein_names_refseq": "WBP-1; WW domain-binding protein 1 isoform 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:22377)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11042109;21750661;21841196;34428180;36210013;7644498", "class_list": "", "function": "Mcl-1 is a determinant of cell fate, and ATF6 mediates apoptosis via specific suppression of Mcl-1 through up-regulation of WBP1, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8WUP5;Q99J20", "ec_number_list": [], "go_molecular_function": "GO:0050699 WW domain binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P97764-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1X4-1", "uniprot_id": [ { "id": "TIM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1X4", "type": "external" } ], "mass": 137503.0, "length": 1197, "protein_name": "Protein timeless homolog", "gene_name": "Timeless", "organism": "Mouse", "refseq_name": "protein timeless homolog isoform 1", "refseq_ac": [ { "id": "NP_001129554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129554", "type": "external" } ], "gene_names_uniprotkb": "Timeless; Tim1; Timeless1", "gene_names_refseq": "Debt69; Timeless; tim", "protein_names_uniprotkb": "Protein timeless homolog; mTim", "protein_names_refseq": "mTim; protein timeless homolog isoform 1; protein timeless homolog", "tax_id": 10090, "disease": "advanced sleep phase syndrome 4 (Disease Ontology:DOID:0061006); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:21853); (R-MMU-5693607)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10231394;10428031;10963667;12875843;14564007;21750661;23418588;24489120;31138685;34418053;34428180;37043347;39627609;9856465;9856466;9891984", "class_list": "", "function": "Circadian protein TIMELESS regulates synaptic function and memory by modulating cAMP signaling., [RefSeq, PubMed]; Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:10428031, PubMed:12875843, PubMed:23418588, PubMed:31138685, PubMed:9856465). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:12875843). During DNA replication, inhibits the CMG complex ATPase activity and activates DNA polymerases catalytic activities, coupling DNA unwinding and DNA synthesis (By similarity). TIMELESS promotes TIPIN nuclear localization (PubMed:12875843, PubMed:31138685). Plays a role in maintaining processive DNA replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures, possibly together with DDX11 (By similarity). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:12875843). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (By similarity). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:23418588). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:10428031, PubMed:23418588, PubMed:31138685). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:9856465). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (PubMed:10963667)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q63ZX9;Q6P204;Q6PDL4;Q7TPV8;Q8R0Q2;Q9R268;Q9Z0E7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008047 enzyme activator activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0031298 replication fork protection complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0035861 site of double-strand break", "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9R1X4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WS1-1", "uniprot_id": [ { "id": "RIMKB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80WS1", "type": "external" } ], "mass": 42528.0, "length": 387, "protein_name": "Beta-citrylglutamate synthase B", "gene_name": "Rimklb", "organism": "Mouse", "refseq_name": "beta-citrylglutamate synthase B", "refseq_ac": [ { "id": "NP_081940", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081940", "type": "external" } ], "gene_names_uniprotkb": "Rimklb; Fam80b; Kiaa1238", "gene_names_refseq": "4931417E21Rik; 4933426K21Rik; Naags; Rimklb", "protein_names_uniprotkb": "Beta-citrylglutamate synthase B; 6.3.1.17; 6.3.2.41; N-acetyl-aspartylglutamate synthetase B; NAAG synthetase B; NAAGS; Ribosomal protein S6 modification-like protein B", "protein_names_refseq": "N-acetyl-aspartyl-glutamate synthetase B; N-acetyl-aspartylglutamate synthetase B; N-acetylaspartyl-glutamate synthetase B; NAAG synthetase B; beta-citryl-glutamate synthase B; beta-citrylglutamate synthase B; ribosomal protein S6 modification-like protein B", "tax_id": 10090, "disease": "", "pathway": " (mmu:108653); (R-MMU-8964539)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "20643647;20657015;21750661;33633267", "class_list": "", "function": "Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate., [UniProtKB, PubMed, PubMed]; Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase., [RefSeq, PubMed]; Rimklb mutation causes male infertility in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZN3;Q8CA77;Q9D3Z1", "ec_number_list": [ { "id": "6.3.2.41", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.41", "type": "external" }, { "id": "6.3.2.42", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.42", "type": "external" }, { "id": "6.3.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.17", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity;GO:0072591 citrate-L-glutamate ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80WS1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DA48-1", "uniprot_id": [ { "id": "SACA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DA48", "type": "external" } ], "mass": 33343.0, "length": 305, "protein_name": "Sperm acrosome membrane-associated protein 1", "gene_name": "Spaca1", "organism": "Mouse", "refseq_name": "sperm acrosome membrane-associated protein 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_080569", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080569", "type": "external" } ], "gene_names_uniprotkb": "Spaca1", "gene_names_refseq": "1700124L11Rik; 4930540L03Rik; Spaca1", "protein_names_uniprotkb": "Sperm acrosome membrane-associated protein 1", "protein_names_refseq": "sperm acrosome membrane-associated protein 1 isoform 1 precursor; sperm acrosome membrane-associated protein 1", "tax_id": 10090, "disease": "spermatogenic failure 85 (Disease Ontology:DOID:0070584)", "pathway": " (mmu:67652)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21750661;22949614;31836887;34231842", "class_list": "", "function": "Cleavage of SPACA1 regulates assembly of sperm-egg membrane fusion machinery in mature spermatozoadagger., [RefSeq, PubMed]; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis. Important for male fertility., [UniProtKB, PubMed]; SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001669 acrosomal vesicle;GO:0002080 acrosomal membrane;GO:0002079 inner acrosomal membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0001675 acrosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DA48-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88878-1", "uniprot_id": [ { "id": "ZFAN5_MOUSE", "url": "https://www.uniprot.org/uniprot/O88878", "type": "external" } ], "mass": 23058.0, "length": 213, "protein_name": "AN1-type zinc finger protein 5", "gene_name": "Zfand5", "organism": "Mouse", "refseq_name": "AN1-type zinc finger protein 5", "refseq_ac": [ { "id": "NP_033577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033577", "type": "external" } ], "gene_names_uniprotkb": "Zfand5; Za20d2; Zfp216; Znf216", "gene_names_refseq": "2310057A04Rik; 5830475F03Rik; Za20d2; Zfand5; Zfp216", "protein_names_uniprotkb": "AN1-type zinc finger protein 5; Zinc finger A20 domain-containing protein 2; Zinc finger protein 216", "protein_names_refseq": "AN1-type zinc finger protein 5; zinc finger A20 domain-containing protein 2; zinc finger protein 216; zinc finger, A20 domain containing 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:22682)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;14754897;16194934;16424905;21183079;21750661;23806337;26495903;30254168;37595557;9758550", "class_list": "", "function": "Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Also inhibits tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation., [UniProtKB, PubMed, PubMed]; Molecular mechanism for activation of the 26S proteasome by ZFAND5., [RefSeq, PubMed]; Unlike other proteasome regulators, ZFAND5 enhances multiple 26S activities and overall cellular protein breakdown. Erratum:[Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1458. doi: 10.1073/pnas.1822050116. PMID: 30642959], [RefSeq, PubMed]; ZNF216 functions in protein degradation via the UPS and plays a crucial role in muscle atrophy., [RefSeq, PubMed]; ZNF216 is a potent inhibitory factor for osteoclast differentiation and the mechanism is unlikely due to direct attenuation of the NF-kappa B pathway, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3B7K8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0003016 respiratory system process;GO:0060324 face development;GO:0048705 skeletal system morphogenesis;GO:0001944 vasculature development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O88878-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZWN5-1", "uniprot_id": [ { "id": "RS9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZWN5", "type": "external" } ], "mass": 22591.0, "length": 194, "protein_name": "Small ribosomal subunit protein uS4", "gene_name": "Rps9", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS4 isoform 1", "refseq_ac": [ { "id": "NP_084043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084043", "type": "external" } ], "gene_names_uniprotkb": "Rps9", "gene_names_refseq": "3010033P07Rik; Rps9", "protein_names_uniprotkb": "Small ribosomal subunit protein uS4; 40S ribosomal protein S9", "protein_names_refseq": "40S ribosomal protein S9; small ribosomal subunit protein uS4 isoform 1; small ribosomal subunit protein uS4", "tax_id": 10090, "disease": "", "pathway": " (mmu:76846); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 13, "publication_id_list": "21750661;22645316;23806337;24788674;33300544;33725478;34428180;36210013;36288343;36517592;37453647;37507081;39627609", "class_list": "", "function": "Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, PubMed]; Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBF1;Q8K2D1", "ec_number_list": [], "go_molecular_function": "GO:0019843 rRNA binding;GO:1990932 5.8S rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q6ZWN5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70281-1", "uniprot_id": [ { "id": "SYCP3_MOUSE", "url": "https://www.uniprot.org/uniprot/P70281", "type": "external" } ], "mass": 29347.0, "length": 254, "protein_name": "Synaptonemal complex protein 3", "gene_name": "Sycp3", "organism": "Mouse", "refseq_name": "synaptonemal complex protein 3", "refseq_ac": [ { "id": "NP_035647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035647", "type": "external" } ], "gene_names_uniprotkb": "Sycp3; Scp3", "gene_names_refseq": "Cor1; Scp3; Sycp3", "protein_names_uniprotkb": "Synaptonemal complex protein 3; SCP-3", "protein_names_refseq": "SCP-3; synaptonemal complex protein 3", "tax_id": 10090, "disease": "spermatogenic failure 4 (Disease Ontology:DOID:0070176); azoospermia (Disease Ontology:DOID:14227)", "pathway": " (mmu:20962)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10678170;11311943;12004129;16717126;21183079;21750661;22346761;22761579;24287868;25428506;27932493;30272023;30746471;30949703;9133341", "class_list": "", "function": "Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:11311943, PubMed:22761579). Required for centromere pairing during meiosis in male germ cells (PubMed:22761579). Required for normal meiosis during spermatogenesis and male fertility (PubMed:10678170). Plays a lesser role in female fertility (PubMed:10678170, PubMed:12004129). Required for efficient phosphorylation of HORMAD1 and HORMAD2 (PubMed:22346761)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2A4;Q549A7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000775 chromosome, centromeric region;GO:0000793 condensed chromosome", "go_biological_process": "GO:0016321 female meiosis chromosome segregation;GO:0007066 female meiosis sister chromatid cohesion;GO:0000278 mitotic cell cycle;GO:0007283 spermatogenesis;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P70281-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQJ4-1", "uniprot_id": [ { "id": "RING2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQJ4", "type": "external" } ], "mass": 37623.0, "length": 336, "protein_name": "E3 ubiquitin-protein ligase RING2", "gene_name": "Rnf2", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RING2", "refseq_ac": [ { "id": "NP_035407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035407", "type": "external" } ], "gene_names_uniprotkb": "Rnf2; DinG; Ring1b", "gene_names_refseq": "Ring1B; Rnf2; dinG", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RING2; 2.3.2.27; RING finger protein 1B; RING finger protein 2; RING-type E3 ubiquitin transferase RING2; RING1b", "protein_names_refseq": "E3 ubiquitin-protein ligase RING2; RING finger protein 1B; RING-type E3 ubiquitin transferase RING2", "tax_id": 10090, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); developmental disorder of mental health (Disease Ontology:DOID:0060037); Luo-Schoch-Yamamoto syndrome (Disease Ontology:DOID:0070416); spina bifida (Disease Ontology:DOID:0080016); cancer (Disease Ontology:DOID:162); pancreatic ductal carcinoma (Disease Ontology:DOID:3587)", "pathway": " (mmu:19821); (R-MMU-3108214); (R-MMU-3899300); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-8939243); (R-MMU-8943724); (R-MMU-8953750)", "pathway_count": 8, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10369680;12183370;15509584;15525528;16024804;16710298;19170609;21750661;22226355;22325148;22872859;24034696;24980959;28596365;28900001;31219806;34428180;36210013;9312051", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15525528, PubMed:22325148, PubMed:28596365). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals (PubMed:15525528, PubMed:28596365). May be involved in the initiation of both imprinted and random X inactivation (PubMed:15525528). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16710298, PubMed:22325148). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:15525528, PubMed:16710298, PubMed:22325148). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:16710298). Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (PubMed:15525528, PubMed:16710298). Plays a role in the transcriptional repression of genes that are required for pluripotency in embryonic stem cells, thereby contributing to differentiation of the ectodermal and endodermal germ layers (PubMed:22226355). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (PubMed:24034696). Also acts as a negative regulator of autophagy by mediating ubiquitination of AMBRA1, leading to its subsequent degradation (PubMed:24980959)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35699;O35729;Q4FJV5;Q8C1X8", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.356", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.356", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0071535 RING-like zinc finger domain binding;GO:0140862 histone H2AK119 ubiquitin ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0000278 mitotic cell cycle;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9CQJ4-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61180-1", "uniprot_id": [ { "id": "SCNNA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61180", "type": "external" } ], "mass": 78893.0, "length": 699, "protein_name": "Epithelial sodium channel subunit alpha", "gene_name": "Scnn1a", "organism": "Mouse", "refseq_name": "epithelial sodium channel subunit alpha isoform 1", "refseq_ac": [ { "id": "NP_035454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035454", "type": "external" } ], "gene_names_uniprotkb": "Scnn1a", "gene_names_refseq": "ENaC; SCNEA; Scnn1a; Scnn1; mENaC", "protein_names_uniprotkb": "Epithelial sodium channel subunit alpha; Alpha-ENaC; Alpha-NaCH; Amiloride-sensitive sodium channel subunit alpha; Epithelial Na(+) channel subunit alpha; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA", "protein_names_refseq": "ENaC alpha; alpha-ENaC; alpha-NaCH; amiloride-sensitive epithelial sodium channel; amiloride-sensitive sodium channel subunit alpha; epithelial Na(+) channel subunit alpha; epithelial sodium channel alpha subunit; epithelial sodium channel subunit alpha isoform 1; epithelial sodium channel subunit alpha; nonvoltage-gated sodium channel 1 subunit alpha; sodium channel, nonvoltage-gated, type I, alpha polypeptide", "tax_id": 10090, "disease": "Liddle syndrome (Disease Ontology:DOID:0050477); stroke (Disease Ontology:DOID:0051061); bronchiectasis 2 (Disease Ontology:DOID:0080527); nephrotic syndrome (Disease Ontology:DOID:1184); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); neurodegenerative disease (Disease Ontology:DOID:1289); hypokalemic periodic paralysis (Disease Ontology:DOID:14452); cystic fibrosis (Disease Ontology:DOID:1485); ischemia (Disease Ontology:DOID:326); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); pseudohypoaldosteronism (Disease Ontology:DOID:4479); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (mmu:20276); (R-MMU-2672351); (R-MMU-9730628)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10409305;11244092;12424229;15007080;15123669;18650438;21750661;22207244;24480829;30659401;36210013;38305875;38349781;8589728;9284273;9326675", "class_list": "", "function": "A mathematical model of ENaC and Slc26a6 regulation by CFTR in salivary gland ducts., [RefSeq, PubMed]; Comprehensive mapping of Epithelial Na[+] channel alpha expression in the mouse brain., [RefSeq, PubMed]; This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:10409305, PubMed:8589728, PubMed:9326675, PubMed:15007080). ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically (PubMed:24480829, PubMed:8589728, PubMed:9326675). It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys (PubMed:9326675). Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance (PubMed:8589728)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9WU37", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0050699 WW domain binding;GO:0015280 ligand-gated sodium channel activity;GO:0005272 sodium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031514 motile cilium", "go_biological_process": "GO:0008217 regulation of blood pressure;GO:1904117 cellular response to vasopressin;GO:0006883 intracellular sodium ion homeostasis;GO:0035725 sodium ion transmembrane transport;GO:1904045 cellular response to aldosterone", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q61180-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28661-1", "uniprot_id": [ { "id": "SEPT4_MOUSE", "url": "https://www.uniprot.org/uniprot/P28661", "type": "external" } ], "mass": 54936.0, "length": 478, "protein_name": "Septin-4", "gene_name": "Septin4", "organism": "Mouse", "refseq_name": "septin-4 isoform 2", "refseq_ac": [ { "id": "NP_001271321", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271321", "type": "external" } ], "gene_names_uniprotkb": "Septin4; Bh5; Gm11492; Pnutl2; Sep4; Sept4", "gene_names_refseq": "ARTS; Bh5; Gm11492; Pnutl2; Sept4; Septin4; hCDCREL-2", "protein_names_uniprotkb": "Septin-4; Bradeion beta; Brain protein H5; CE5B3 beta; Cell division control-related protein 2; Peanut-like protein 2; hCDCREL-2", "protein_names_refseq": "CE5B3 beta; M-Septin; bradeion beta; brain protein H5; cell division control-related protein 2b; peanut-like 2 homolog; peanut-like protein 2; septin H5; septin-4 isoform 2", "tax_id": 10090, "disease": "Lewy body dementia (Disease Ontology:DOID:12217); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:18952); (R-MMU-111457); (R-MMU-111469)", "pathway_count": 3, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;12106288;12581152;15737930;15737931;16452087;17242355;17296554;17546647;18938227;20181826;20952537;21183079;21679490;21750661;23479728;23788729;27811987;28346465;30084848;30389919;34189751;34428180;36715674;36786216;38171099", "class_list": "", "function": "ARTS is essential for di-2-ethylhexyl phthalate (DEHP)-induced apoptosis of mouse Leydig cells., [RefSeq, PubMed]; Deacetylation of Septin4 by SIRT2 (Silent Mating Type Information Regulation 2 Homolog-2) Mitigates Damaging of Hypertensive Nephropathy., [RefSeq, PubMed]; Filament-forming cytoskeletal GTPase (Probable). Pro-apoptotic protein involved in LGR5-positive intestinal stem cell and Paneth cell expansion in the intestines, via its interaction with XIAP (PubMed:30389919). May also play a role in the regulation of cell fate in the intestine (PubMed:30389919). Positive regulator of apoptosis involved in hematopoietic stem cell homeostasis; via its interaction with XIAP (PubMed:20952537). Negative regulator of repair and hair follicle regeneration in response to injury, due to inhibition of hair follicle stem cell proliferation, potentially via its interaction with XIAP (PubMed:23788729). Plays an important role in male fertility and sperm motility (PubMed:15737930, PubMed:15737931). During spermiogenesis, essential for the establishment of the annulus (a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum) which is a requisite for the structural and mechanical integrity of the sperm (PubMed:15737930, PubMed:15737931). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (PubMed:20181826). Required for dopaminergic metabolism in presynaptic autoreceptors; potentially via activity as a presynaptic scaffold protein (PubMed:17296554)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Proper phosphorylation of septin 12 regulates septin 4 and soluble adenylyl cyclase expression to induce sperm capacitation., [RefSeq, PubMed]; Septin 4 controls CCNB1 stabilization via APC/C(CDC20) during meiotic G2/M transition in mouse oocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2KGM3;B2KGM6;Q3UVH1;Q3UZC3;Q5ND10;Q5ND15;Q5ND16;Q5ND19;Q7TPM7;Q80VX1", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0097227 sperm annulus;GO:0005940 septin ring;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0030382 sperm mitochondrion organization;GO:0048729 tissue morphogenesis;GO:2000647 negative regulation of stem cell proliferation;GO:0043065 positive regulation of apoptotic process;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P28661-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PP2-1", "uniprot_id": [ { "id": "ZN318_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PP2", "type": "external" } ], "mass": 246324.0, "length": 2237, "protein_name": "Zinc finger protein 318", "gene_name": "Zfp318; Znf318", "organism": "Mouse", "refseq_name": "zinc finger protein 318 isoform 2", "refseq_ac": [ { "id": "NP_067321", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067321", "type": "external" } ], "gene_names_uniprotkb": "Zfp318; Znf318; Tzf; Zfp318", "gene_names_refseq": "2610034E08Rik; D530032D06Rik; TZF; Zfp318; Znf318", "protein_names_uniprotkb": "Zinc finger protein 318; Testicular zinc finger protein", "protein_names_refseq": "testicular zinc finger protein; zinc finger protein 318 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:57908)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10873617;12589823;15882980;16446156;21183079;21606357;21750661;22645316;24616512;25057009;25428506;27385512;28011936;30084848;30779550;31160601;31219806;34418053;34428180;36852467;40885482;40997131", "class_list": "", "function": "Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and in particular, during meiotic division., [UniProtKB, PubMed, PubMed]; Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and in particular, during meiotic division., [UniProtKB, PubMed, PubMed, PubMed]; Ampk regulates IgD expression but not energy stress with B cell activation. Publication Status: Online-Only, [RefSeq, PubMed]; Findings identify ZFP318 as a crucial factor regulating the expression of the two major antibody isotypes on the surface of most mature B cells, [RefSeq, PubMed]; In the unique regulation system of AR-mediated transactivation, two spliced isoforms of TZF act as coactivator and corepressor, respectively, [RefSeq, PubMed]; Molecular cloning and characteristics of a novel zinc finger protein and its splice variant whose transcripts are expressed during spermatogenesis., [RefSeq, PubMed]; This finding indicates that Zfp318, in a novel manner, functions by repressing recognition of the transcriptional termination site at the 3' end of the terminal IgM-encoding exon, [RefSeq, PubMed]; Zfp318 is expressed as a functional protein in testicular germ cells and plays an important role in meiosis during spermatogenesis., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "B0V2M3;B9EK88;Q3TZL5;Q8BMX9;Q9JJ01", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q99PP2-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00724-1", "uniprot_id": [ { "id": "RET4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q00724", "type": "external" } ], "mass": 23206.0, "length": 201, "protein_name": "Retinol-binding protein 4", "gene_name": "Rbp4", "organism": "Mouse", "refseq_name": "retinol-binding protein 4 isoform 1", "refseq_ac": [ { "id": "NP_001152959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152959", "type": "external" } ], "gene_names_uniprotkb": "Rbp4", "gene_names_refseq": "Rbp-4; Rbp4", "protein_names_uniprotkb": "Retinol-binding protein 4; PRBP; Plasma retinol-binding protein; RBP", "protein_names_refseq": "PRBP; RBP; plasma retinol-binding protein; retinol binding protein 4, cellular; retinol-binding protein 4 isoform 1; retinol-binding protein 4", "tax_id": 10090, "disease": "colon adenoma (Disease Ontology:DOID:0050912); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); diabetic angiopathy (Disease Ontology:DOID:11713); gestational diabetes (Disease Ontology:DOID:11714); dilated cardiomyopathy (Disease Ontology:DOID:12930); severe pre-eclampsia (Disease Ontology:DOID:13129); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); familial hypercholesterolemia (Disease Ontology:DOID:13810); atherosclerosis (Disease Ontology:DOID:1936); hyperinsulinism (Disease Ontology:DOID:2018); gallbladder cancer (Disease Ontology:DOID:3121); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); systemic scleroderma (Disease Ontology:DOID:418); liver cirrhosis (Disease Ontology:DOID:5082); acute pyelonephritis (Disease Ontology:DOID:559); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); chronic kidney disease (Disease Ontology:DOID:784); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:19662); (R-MMU-2453902); (R-MMU-975634)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "1613076;21750661;22872234;24129315;26495903;34428180;37453647;37507081;39031684;9721191", "class_list": "", "function": "RBP4 promotes denervation-induced muscle atrophy through STRA6-dependent pathway., [RefSeq, PubMed]; Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 25, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70357;Q566I5", "ec_number_list": [], "go_molecular_function": "GO:0019841 retinol binding;GO:0044877 protein-containing complex binding;GO:0016918 retinal binding;GO:0034632 retinol transmembrane transporter activity;GO:0140104 molecular carrier activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0001523 retinoid metabolic process;GO:0007283 spermatogenesis;GO:0007507 heart development;GO:0032024 positive regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q00724-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97428-1", "uniprot_id": [ { "id": "RGS16_MOUSE", "url": "https://www.uniprot.org/uniprot/P97428", "type": "external" } ], "mass": 22691.0, "length": 201, "protein_name": "Regulator of G protein signaling 16", "gene_name": "Rgs16", "organism": "Mouse", "refseq_name": "regulator of G-protein signaling 16", "refseq_ac": [ { "id": "NP_035397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035397", "type": "external" } ], "gene_names_uniprotkb": "Rgs16; Rgsr", "gene_names_refseq": "Rgs14; Rgs16; Rgsr", "protein_names_uniprotkb": "Regulator of G protein signaling 16; A28-RGS14P; RGS-r; RGS16; Retinal-specific RGS; Retinally abundant regulator of G protein signaling", "protein_names_refseq": "A28-RGS14P; RGS-R; regulator of G-protein signaling 16; retinal-specific RGS; retinally abundant regulator of G-protein signaling", "tax_id": 10090, "disease": "", "pathway": " (mmu:19734); (R-MMU-416476); (R-MMU-418594); (R-MMU-418597)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10373502;11522288;18434540;28235863;30791801;35622904;38141114;8917514;9079700;9223279;9469939", "class_list": "", "function": "Cytoplasm, GTPase activator, signal transduction and G-protein coupled receptor protein signaling pathway, [RefSeq, PubMed]; Phosphorylation of RGS16 at Tyr168 promote HBeAg-mediated macrophage activation by ERK pathway to accelerate liver injury., [RefSeq, PubMed]; RGS 16 has critical roles in regulating hemostatic and thrombotic functions of platelets in mice., [RefSeq, PubMed]; Regulates G protein-coupled receptor signaling cascades (PubMed:9079700). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:10373502). Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha (PubMed:8917514). May regulate extra and intracellular mitogenic signals., [UniProtKB, PubMed, PubMed]; Rgs16 promotes antitumor CD8(+) T cell exhaustion., [RefSeq, PubMed]; This study reveals how RGS proteins modulate Galphai2 signaling to facilitate thymocyte egress and T cell trafficking., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09091;P97420;Q80V16", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0043547 positive regulation of GTPase activity;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P97428-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SVD0-1", "uniprot_id": [ { "id": "RFLB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SVD0", "type": "external" } ], "mass": 23380.0, "length": 216, "protein_name": "Refilin-B", "gene_name": "Rflnb", "organism": "Mouse", "refseq_name": "refilin-B", "refseq_ac": [ { "id": "NP_083934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083934", "type": "external" } ], "gene_names_uniprotkb": "Rflnb; Cfm1; Fam101b", "gene_names_refseq": "1500005K14Rik; Fam101b; RefilinB; Rflnb; cfm", "protein_names_uniprotkb": "Refilin-B; RefilinB; Regulator of filamin protein B", "protein_names_refseq": "family with sequence similarity 101, member B; filamin-interacting protein FAM101B; protein FAM101B; refilin-B; regulator of filamin protein B", "tax_id": 10090, "disease": "", "pathway": " (mmu:76566)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21709252;24436304", "class_list": "", "function": "Filamin a, b-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeleton., [RefSeq, PubMed]; Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DB69", "ec_number_list": [], "go_molecular_function": "GO:0031005 filamin binding", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0032432 actin filament bundle", "go_biological_process": "GO:1900158 negative regulation of bone mineralization involved in bone maturation;GO:0061572 actin filament bundle organization;GO:0030036 actin cytoskeleton organization;GO:0048705 skeletal system morphogenesis;GO:0001837 epithelial to mesenchymal transition", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5SVD0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62301-1", "uniprot_id": [ { "id": "RS13_MOUSE", "url": "https://www.uniprot.org/uniprot/P62301", "type": "external" } ], "mass": 17222.0, "length": 151, "protein_name": "Small ribosomal subunit protein uS15", "gene_name": "Rps13", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS15", "refseq_ac": [ { "id": "NP_080809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080809", "type": "external" } ], "gene_names_uniprotkb": "Rps13", "gene_names_refseq": "2700063M04Rik; Rps13", "protein_names_uniprotkb": "Small ribosomal subunit protein uS15; 40S ribosomal protein S13", "protein_names_refseq": "40S ribosomal protein S13; small ribosomal subunit protein uS15", "tax_id": 10090, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (mmu:68052); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 14, "publication_id_list": "21750661;23806337;25605945;26740625;28315936;31219806;34428180;35820727;35984892;36210013;36288343;36517592;37453647;39627609", "class_list": "", "function": "Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:1990932 5.8S rRNA binding;GO:0048027 mRNA 5'-UTR binding;GO:0003735 structural constituent of ribosome;GO:0070181 small ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:0033119 negative regulation of RNA splicing;GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P62301-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62908-1", "uniprot_id": [ { "id": "RS3_MOUSE", "url": "https://www.uniprot.org/uniprot/P62908", "type": "external" } ], "mass": 26674.0, "length": 243, "protein_name": "Small ribosomal subunit protein uS3", "gene_name": "Rps3", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS3", "refseq_ac": [ { "id": "NP_036182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036182", "type": "external" } ], "gene_names_uniprotkb": "Rps3", "gene_names_refseq": "D7Ertd795e; Rps3; Rs_3", "protein_names_uniprotkb": "Small ribosomal subunit protein uS3; 4.2.99.18; 40S ribosomal protein S3", "protein_names_refseq": "40S ribosomal protein S3; small ribosomal subunit protein uS3", "tax_id": 10090, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (mmu:27050); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 26, "publication_id_list": "14988002;17114649;17242355;19129230;19144319;21183079;21540332;21750661;23806337;24145029;26740625;28575669;30213050;31219806;33300544;34428180;34678516;34887587;35984892;36288343;36517592;37453647;39627609;39927985;40021952;7775413", "class_list": "", "function": "Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (By similarity). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (By similarity). Has also been shown to bind with similar affinity to intact and damaged DNA (By similarity). Stimulates the N-glycosylase activity of the base excision protein OGG1 (By similarity). Enhances the uracil excision activity of UNG1 (By similarity). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (By similarity). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (By similarity). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (By similarity). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (By similarity). Represses its own translation by binding to its cognate mRNA (By similarity). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (By similarity). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (By similarity). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (By similarity). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P17073;P47933", "ec_number_list": [ { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "1.14.11.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.51", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.33", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.33", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0032357 oxidized purine DNA binding;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0007059 chromosome segregation;GO:0010628 positive regulation of gene expression;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P62908-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62245-1", "uniprot_id": [ { "id": "RS15A_MOUSE", "url": "https://www.uniprot.org/uniprot/P62245", "type": "external" } ], "mass": 14840.0, "length": 130, "protein_name": "Small ribosomal subunit protein uS8", "gene_name": "Rps15a", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS8", "refseq_ac": [ { "id": "NP_733769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_733769", "type": "external" } ], "gene_names_uniprotkb": "Rps15a", "gene_names_refseq": "A630031B11Rik; Rps15a", "protein_names_uniprotkb": "Small ribosomal subunit protein uS8; 40S ribosomal protein S15a", "protein_names_refseq": "40S ribosomal protein S15a; small ribosomal subunit protein uS8", "tax_id": 10090, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); Diamond-Blackfan anemia 20 (Disease Ontology:DOID:0111891)", "pathway": " (mmu:267019); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 23, "publication_id_list": "18299400;20173027;21750661;21913724;21952136;22645316;23806337;25428506;25428507;25605945;30084848;30779550;31599954;33649389;34428180;35820727;36210013;36517592;37378633;37453647;37507081;39627609;7522249", "class_list": "", "function": "Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Required for proper erythropoiesis (By similarity)., [UniProtKB, UniProtKB, PubMed]; Elevated FBXL18 promotes RPS15A ubiquitination and SMAD3 activation to drive HCC. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P39027;P39031;Q8C023;Q9BV24", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0009615 response to virus;GO:0045787 positive regulation of cell cycle;GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P62245-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60867-1", "uniprot_id": [ { "id": "RS20_MOUSE", "url": "https://www.uniprot.org/uniprot/P60867", "type": "external" } ], "mass": 13373.0, "length": 119, "protein_name": "Small ribosomal subunit protein uS10", "gene_name": "Rps20", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS10", "refseq_ac": [ { "id": "NP_080423", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080423", "type": "external" } ], "gene_names_uniprotkb": "Rps20", "gene_names_refseq": "4632426K06Rik; Dsk4; Rps20", "protein_names_uniprotkb": "Small ribosomal subunit protein uS10; 40S ribosomal protein S20", "protein_names_refseq": "40S ribosomal protein S20; small ribosomal subunit protein uS10", "tax_id": 10090, "disease": "Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (mmu:67427); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 9, "publication_id_list": "23806337;25605945;28575669;34428180;35820727;36288343;36517592;37453647;39627609", "class_list": "", "function": "Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]; Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P17075", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0097371 MDM2/MDM4 family protein binding;GO:1990948 ubiquitin ligase inhibitor activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse", "go_biological_process": "GO:1901798 positive regulation of signal transduction by p53 class mediator;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P60867-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62702-1", "uniprot_id": [ { "id": "RS4X_MOUSE", "url": "https://www.uniprot.org/uniprot/P62702", "type": "external" } ], "mass": 29598.0, "length": 263, "protein_name": "Small ribosomal subunit protein eS4", "gene_name": "Rps4x", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein eS4 isoform 2", "refseq_ac": [ { "id": "NP_033120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033120", "type": "external" } ], "gene_names_uniprotkb": "Rps4x; Rps4", "gene_names_refseq": "Rps4-1; Rps4x; Rps4", "protein_names_uniprotkb": "Small ribosomal subunit protein eS4; 40S ribosomal protein S4, X isoform", "protein_names_refseq": "small ribosomal subunit protein eS4 isoform 2; small ribosomal subunit protein eS4", "tax_id": 10090, "disease": "", "pathway": " (mmu:20102); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;1740345;1783379;23806337;25605945;31219806;33300544;34428180;35820727;36288343;36517592;37453647;37507081;37828378;39627609", "class_list": "", "function": "Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P12631;P12750;P27576;P55831;Q14727;Q9CXN0", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0005840 ribosome", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0006412 translation;GO:0045727 positive regulation of translation;GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P62702-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62918-1", "uniprot_id": [ { "id": "RL8_MOUSE", "url": "https://www.uniprot.org/uniprot/P62918", "type": "external" } ], "mass": 28025.0, "length": 257, "protein_name": "Large ribosomal subunit protein uL2", "gene_name": "Rpl8", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL2", "refseq_ac": [ { "id": "NP_036183", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036183", "type": "external" } ], "gene_names_uniprotkb": "Rpl8", "gene_names_refseq": "Rpl8", "protein_names_uniprotkb": "Large ribosomal subunit protein uL2; 60S ribosomal protein L8", "protein_names_refseq": "60S ribosomal protein L8; large ribosomal subunit protein uL2", "tax_id": 10090, "disease": "Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (mmu:26961); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-9629569); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 12, "publication_count": 17, "publication_id_list": "19129230;25428506;26495903;26740625;29187734;31219806;33300544;33725478;34428180;35820727;35984892;36210013;36288343;36517592;37453647;37828378;39627609", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P25120;Q3V288", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:1990932 5.8S rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation;GO:0140236 translation at presynapse", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P62918-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62983-1", "uniprot_id": [ { "id": "RS27A_MOUSE", "url": "https://www.uniprot.org/uniprot/P62983", "type": "external" } ], "mass": 17951.0, "length": 156, "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "Rps27a", "organism": "Mouse", "refseq_name": "ubiquitin-ribosomal protein eS31 fusion protein precursor", "refseq_ac": [ { "id": "NP_001029037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029037", "type": "external" } ], "gene_names_uniprotkb": "Rps27a; Uba80; Ubcep1", "gene_names_refseq": "0610006J14Rik; Rps27a; Uba52; Ubb; Ubc", "protein_names_uniprotkb": "Ubiquitin-ribosomal protein eS31 fusion protein; 40S ribosomal protein S27a; Ubiquitin carboxyl extension protein 80", "protein_names_refseq": "ubiquitin carboxyl extension protein 80; ubiquitin-40S ribosomal protein S27a; ubiquitin-ribosomal protein eS31 fusion protein precursor; ubiquitin-ribosomal protein eS31 fusion protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:78294); (R-MMU-110312); (R-MMU-110314); (R-MMU-110320); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1253288); (R-MMU-1295596); (R-MMU-1358803); (R-MMU-168638); (R-MMU-174048); (R-MMU-174084); (R-MMU-174113); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-179409); (R-MMU-182971); (R-MMU-187577); (R-MMU-195253); (R-MMU-201681); (R-MMU-202424); (R-MMU-205043); (R-MMU-209543); (R-MMU-209560); (R-MMU-2122948); (R-MMU-2173788); (R-MMU-2173791); (R-MMU-2173795); (R-MMU-2173796); (R-MMU-2467813); (R-MMU-2559580); (R-MMU-2559582); (R-MMU-2559585); (R-MMU-2565942); (R-MMU-2672351); (R-MMU-2871837); (R-MMU-3134975); (R-MMU-349425); (R-MMU-3769402); (R-MMU-382556); (R-MMU-445989); (R-MMU-450302); (R-MMU-450321); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-4641263); (R-MMU-5205685); (R-MMU-532668); (R-MMU-5357905); (R-MMU-5357956); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5654726); (R-MMU-5654727); (R-MMU-5654732); (R-MMU-5654733); (R-MMU-5655862); (R-MMU-5656121); (R-MMU-5656169); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5675221); (R-MMU-5675482); (R-MMU-5676590); (R-MMU-5684264); (R-MMU-5685942); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689877); (R-MMU-5689880); (R-MMU-5689896); (R-MMU-5689901); (R-MMU-5693537); (R-MMU-5693565); (R-MMU-5693607); (R-MMU-5696394); (R-MMU-5696395); (R-MMU-5696397); (R-MMU-5696400); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6783310); (R-MMU-6804756); (R-MMU-6804757); (R-MMU-6804760); (R-MMU-6807004); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69231); (R-MMU-69481); (R-MMU-69541); (R-MMU-69601); (R-MMU-75815); (R-MMU-8849469); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-8863795); (R-MMU-8866427); (R-MMU-8866652); (R-MMU-8866654); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948747); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-901032); (R-MMU-9010553); (R-MMU-9013507); (R-MMU-9020702); (R-MMU-9033241); (R-MMU-909733); (R-MMU-912631); (R-MMU-917729); (R-MMU-917937); (R-MMU-936440); (R-MMU-936964); (R-MMU-937039); (R-MMU-937041); (R-MMU-937042); (R-MMU-937072); (R-MMU-9645460); (R-MMU-9646399); (R-MMU-9648002); (R-MMU-9664873); (R-MMU-9705462); (R-MMU-9706369); (R-MMU-9708530); (R-MMU-975144); (R-MMU-975163); (R-MMU-9755511); (R-MMU-9758274); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-9770562); (R-MMU-9824878); (R-MMU-983168); (R-MMU-9861718); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9931295); (R-MMU-9932298); (R-MMU-9954709); (R-MMU-9954716); (R-MMU-9958810); (R-MMU-9958825)", "pathway_count": 158, "publication_count": 14, "publication_id_list": "11180120;16075062;19754430;21540332;22158882;23806337;25605945;33300544;33725478;34428180;35820727;36288343;37453647;37828378", "class_list": "", "function": "Component of the 40S subunit of the ribosome (PubMed:19754430). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, PubMed]; Effector of HBx protein-mediated hepatocarcinogenesis, [RefSeq, PubMed]; Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02248;P02249;P02250;P49664;P62991;Q29120;Q62317;Q64223;Q8VCH1;Q91887;Q91888;Q9CXY4;Q9CZM0;Q9D1R5;Q9D2W3;Q9D8D9;Q9ET23;Q9ET24;Q9Z0H9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0019941 modification-dependent protein catabolic process;GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis;GO:0140236 translation at presynapse", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P62983-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63276-1", "uniprot_id": [ { "id": "RS17_MOUSE", "url": "https://www.uniprot.org/uniprot/P63276", "type": "external" } ], "mass": 15524.0, "length": 135, "protein_name": "Small ribosomal subunit protein eS17", "gene_name": "Rps17", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein eS17", "refseq_ac": [ { "id": "NP_033118", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033118", "type": "external" } ], "gene_names_uniprotkb": "Rps17", "gene_names_refseq": "Rps17", "protein_names_uniprotkb": "Small ribosomal subunit protein eS17; 40S ribosomal protein S17", "protein_names_refseq": "40S ribosomal protein S17; small ribosomal subunit protein eS17", "tax_id": 10090, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); hyperphosphatasia with impaired intellectual development syndrome 1 (Disease Ontology:DOID:0070433); Diamond-Blackfan anemia 4 (Disease Ontology:DOID:0111890); Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (mmu:20068); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 13, "publication_count": 14, "publication_id_list": "15345747;21183079;22645316;23806337;25605945;28528544;31219806;33725478;34428180;35820727;36517592;37453647;37507081;7748157", "class_list": "", "function": "Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P06584", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse;GO:0005840 ribosome", "go_biological_process": "GO:0006412 translation;GO:0034101 erythrocyte homeostasis;GO:0006364 rRNA processing;GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P63276-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NS46-1", "uniprot_id": [ { "id": "RRP5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NS46", "type": "external" } ], "mass": 207779.0, "length": 1862, "protein_name": "Protein RRP5 homolog", "gene_name": "Pdcd11", "organism": "Mouse", "refseq_name": "protein RRP5 homolog", "refseq_ac": [ { "id": "NP_035183", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035183", "type": "external" } ], "gene_names_uniprotkb": "Pdcd11; Alg4; Kiaa0185", "gene_names_refseq": "1110021I22Rik; ALG-4; Pdcd11; Pdcd7; mKIAA0185", "protein_names_uniprotkb": "Protein RRP5 homolog; Apoptosis-linked gene 4 protein; Programmed cell death protein 11", "protein_names_refseq": "apoptosis-linked gene 4 protein; programmed cell death protein 11; programmed cell death protein 7; protein RRP5 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:18572); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10229231;21183079;22645316;22872234;25428506;25428507;25605945;30084848;30779550;31219806;34428180;35820727;36210013;37828378", "class_list": "", "function": "Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSU4;Q3UGG2;Q3URK0;Q6PIA8;Q6ZQH2;Q7TPE2;Q9CTD8;Q9R1Z2;Q9WTU7", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0051059 NF-kappaB binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0032040 small-subunit processome", "go_biological_process": "GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q6NS46-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BYM7-1", "uniprot_id": [ { "id": "RSH4A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BYM7", "type": "external" } ], "mass": 80146.0, "length": 716, "protein_name": "Radial spoke head protein 4 homolog A", "gene_name": "Rsph4a", "organism": "Mouse", "refseq_name": "radial spoke head protein 4 homolog A", "refseq_ac": [ { "id": "NP_001156429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156429", "type": "external" } ], "gene_names_uniprotkb": "Rsph4a; Rshl3", "gene_names_refseq": "A230081C05; Rshl3; Rsph4a", "protein_names_uniprotkb": "Radial spoke head protein 4 homolog A; Radial spoke head-like protein 3", "protein_names_refseq": "radial spoke head protein 4 homolog A; radial spoke head-like protein 3; radial spokehead-like 3", "tax_id": 10090, "disease": "primary ciliary dyskinesia 11 (Disease Ontology:DOID:0110602)", "pathway": " (mmu:212892)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;30239614;32203505;34871179", "class_list": "", "function": "Functions as part of axonemal radial spoke complexes that play an important role in ciliary motility (PubMed:32203505, PubMed:34871179). Essential for triplet radial spokes (RS1, RS2 and RS3) head assembly in the motile cilia (PubMed:32203505)., [UniProtKB, PubMed, PubMed]; Results suggest Rsph4a is a generic component of radial spoke heads, and could explain the severe phenotype of human PCD patients with RSPH4A mutation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RQN0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001534 radial spoke;GO:0005576 extracellular region;GO:0005929 cilium;GO:0005930 axoneme;GO:0097729 9+2 motile cilium", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0003341 cilium movement;GO:0035082 axoneme assembly;GO:0062177 radial spoke assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BYM7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99K70-1", "uniprot_id": [ { "id": "RRAGC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99K70", "type": "external" } ], "mass": 44121.0, "length": 398, "protein_name": "Ras-related GTP-binding protein C", "gene_name": "Rragc", "organism": "Mouse", "refseq_name": "ras-related GTP-binding protein C", "refseq_ac": [ { "id": "NP_059503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059503", "type": "external" } ], "gene_names_uniprotkb": "Rragc", "gene_names_refseq": "Gtr2; RAGC; Rragc; TIB929; YGR163W", "protein_names_uniprotkb": "Ras-related GTP-binding protein C; 3.6.5.-; GTPase-interacting protein 2; Rag C; RagC; TIB929", "protein_names_refseq": "GTPase-interacting protein 2; rag C; ras-related GTP-binding protein C; small GTPase, homolog", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); follicular lymphoma (Disease Ontology:DOID:0050873); candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:54170); (R-MMU-1632852); (R-MMU-165159); (R-MMU-166208); (R-MMU-380972); (R-MMU-5628897); (R-MMU-8943724); (R-MMU-9639288)", "pathway_count": 8, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10660099;19144319;22442136;22645316;25153642;25259925;28135057;28528544;29158492;29644770;30595499;31219806;33300544;34203471;34253722;34428180;37507081", "class_list": "", "function": "Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form: RagC/RRAGC is in its active form when GDP-bound RagC/RRAGC forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagC/RRAGC heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB). In its GDP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the MTOR signaling cascade by amino acids. Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3: GDP-bound RagC/RRAGC mediates recruitment of MiT/TFE factors TFEB and TFE3., [UniProtKB, UniProtKB]; TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism. Publication Status: Online-Only, [RefSeq, PubMed]; The constitutively active RagA-RagC heterodimer blocks the inhibitory effect of alcohol (EtOH)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2A7K7;Q3TL69;Q6IQZ6;Q8CFT7;Q9Z124", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046982 protein heterodimerization activity;GO:0051020 GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005764 lysosome", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0000045 autophagosome assembly;GO:1900181 negative regulation of protein localization to nucleus;GO:0007040 lysosome organization;GO:0010507 negative regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q99K70-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PL5-1", "uniprot_id": [ { "id": "RRBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PL5", "type": "external" } ], "mass": 172879.0, "length": 1605, "protein_name": "Ribosome-binding protein 1", "gene_name": "Rrbp1", "organism": "Mouse", "refseq_name": "ribosome-binding protein 1 isoform a", "refseq_ac": [ { "id": "NP_077243", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077243", "type": "external" } ], "gene_names_uniprotkb": "Rrbp1", "gene_names_refseq": "1700087N07Rik; 5730465C04Rik; ES/130; Rrbp1; mKIAA1398; mRRp0; mRRp1.8; mRRp10; mRRp15a; mRRp15b; mRRp16.8; mRRp2; mRRp41; mRRp47; mRRp5.4; p180", "protein_names_uniprotkb": "Ribosome-binding protein 1; RRp; Ribosome receptor protein; mRRp", "protein_names_refseq": "RRp; mRRp; ribosome receptor protein; ribosome-binding protein 1 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:81910)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;11167022;18630941;20173027;21183079;21750661;22645316;22872234;23806337;26495903;26740625;33649389;34203471;34418053;34428180;34887587;35820727;36170592;36210013;36288343;37453647;37828378;39627609;40021952;40885482", "class_list": "", "function": "Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane., [UniProtKB, UniProtKB, UniProtKB]; Mitochondria-ER cooperation: NLRX1 detects mitochondrial protein import stress and promotes mitophagy through the ER protein RRBP1., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A2AVJ8;Q99PK5;Q99PK6;Q99PK7;Q99PK8;Q99PK9;Q99PL0;Q99PL1;Q99PL2;Q99PL3;Q99PL4;Q9CS20", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q99PL5-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMD8-1", "uniprot_id": [ { "id": "SCMC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMD8", "type": "external" } ], "mass": 52902.0, "length": 475, "protein_name": "Mitochondrial adenyl nucleotide antiporter SLC25A24", "gene_name": "Slc25a24", "organism": "Mouse", "refseq_name": "mitochondrial adenyl nucleotide antiporter SLC25A24", "refseq_ac": [ { "id": "NP_766273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766273", "type": "external" } ], "gene_names_uniprotkb": "Slc25a24; Scamc1", "gene_names_refseq": "2610016M12Rik; SCaMC-1; Slc25a24", "protein_names_uniprotkb": "Mitochondrial adenyl nucleotide antiporter SLC25A24; SCaMC-1; Small calcium-binding mitochondrial carrier protein 1; Solute carrier family 25 member 24", "protein_names_refseq": "calcium-binding mitochondrial carrier protein SCaMC-1; mitochondrial adenyl nucleotide antiporter SLC25A24; small calcium-binding mitochondrial carrier protein 1; solute carrier family 25 member 24", "tax_id": 10090, "disease": "", "pathway": " (mmu:229731)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15054102;21750661;22015608;23806337;25599384;31219806;34203471;38164038", "class_list": "", "function": "Arginine-methylated c-Myc affects mitochondrial mitophagy in mouse acute kidney injury via Slc25a24., [RefSeq, PubMed]; Electroneutral antiporter that mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenyl nucleotide pool, could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways. In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides. May play a role in protecting cells against oxidative stress-induced cell death, by buffering calcium levels in the mitochondrial matrix through the formation of calcium-phosphate precipitates., [UniProtKB, UniProtKB]; Genetic analyses in human and mouse models revealed the importance of SLC25A24/Slc25a24 in the regulation of body fat mass and adipogenesis., [RefSeq, PubMed]; SCaMC-1 exerts a negative feedback control between cellular Ca(2+) overload and mPT-dependent cell death, suggesting that the carrier might represent a novel target for cancer therapy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCQ2;Q3THY3;Q7TPC2", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0000295 adenine nucleotide transmembrane transporter activity;GO:0005347 ATP transmembrane transporter activity;GO:0140987 ATP:phosphate antiporter activity;GO:0140988 ADP:phosphate antiporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0006839 mitochondrial transport;GO:0071277 cellular response to calcium ion;GO:0034599 cellular response to oxidative stress;GO:0015866 ADP transport;GO:0015867 ATP transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BMD8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BUH8-1", "uniprot_id": [ { "id": "SENP7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BUH8", "type": "external" } ], "mass": 116346.0, "length": 1037, "protein_name": "Sentrin-specific protease 7", "gene_name": "Senp7", "organism": "Mouse", "refseq_name": "sentrin-specific protease 7 isoform 1", "refseq_ac": [ { "id": "NP_079759", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079759", "type": "external" } ], "gene_names_uniprotkb": "Senp7; Kiaa1707; Susp2", "gene_names_refseq": "2410152H17Rik; 2810413I22Rik; 2900036C23Rik; 6030449K19Rik; Senp7", "protein_names_uniprotkb": "Sentrin-specific protease 7; 3.4.22.-; SUMO-1-specific protease 2; Sentrin/SUMO-specific protease SENP7", "protein_names_refseq": "SUMO-1-specific protease 2; SUMO1/sentrin specific protease 7; sentrin-specific protease 7 isoform 1; sentrin-specific protease 7; sentrin/SUMO-specific protease SENP7", "tax_id": 10090, "disease": "acute promyelocytic leukemia (Disease Ontology:DOID:0060318)", "pathway": " (mmu:66315)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;22388734;28095500;28528544;30084848;30779550;34428180;38677512", "class_list": "", "function": "Depletion of Senp7 delocalizes HP1 alpha from pericentric heterochromatin without affecting H3K9me3 levels. Publication Status: Online-Only, [RefSeq, PubMed]; Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS (PubMed:28095500). Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (PubMed:28095500). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (By similarity). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (By similarity). Has very low efficiency in processing full-length SUMO proteins to their mature forms (By similarity)., [UniProtKB, UniProtKB, PubMed]; Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation., [RefSeq, PubMed]; This gene encodes a SUMO deconjugating enzyme of the Sentrin/SUMO-specific protease (SENP) family. The encoded protein is a protease that exhibits deSUMOylating activity towards proteins involved in chromatin remodeling and promotes chromatin relaxation for DNA repair or transcription. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P398;Q80TA3", "ec_number_list": [], "go_molecular_function": "GO:0070139 SUMO-specific endopeptidase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0099523 presynaptic cytosol;GO:0099524 postsynaptic cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016926 protein desumoylation;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8BUH8-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHW4-1", "uniprot_id": [ { "id": "SELB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHW4", "type": "external" } ], "mass": 63539.0, "length": 583, "protein_name": "Selenocysteine-specific elongation factor", "gene_name": "Eefsec", "organism": "Mouse", "refseq_name": "selenocysteine-specific elongation factor isoform 1", "refseq_ac": [ { "id": "NP_075547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075547", "type": "external" } ], "gene_names_uniprotkb": "Eefsec; Selb", "gene_names_refseq": "Eefsec; Selb; mSelB; sec", "protein_names_uniprotkb": "Selenocysteine-specific elongation factor; 3.6.5.-; Elongation factor sec; Eukaryotic elongation factor, selenocysteine-tRNA-specific; mSelB", "protein_names_refseq": "MJ0495-like protein SelB; elongation factor sec; selenocysteine-specific elongation factor isoform 1; selenocysteine-specific elongation factor", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:65967)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10970870;11265756;20173027;21183079;21750661;22992746;24129315;27802322;34428180", "class_list": "", "function": "SBP2/SECIS complex activates eEFSec by directing functional interactions between Domain IV and the ribosome to promote Sec-tRNA(Sec) binding and accommodation into the ribosomal A-site, [RefSeq, PubMed]; This study examined the subcellular localization of eEFSec in the context of altered Selenocysteine incorporation to demonstrate that reduced selenoprotein production does not correlate with changes in the nuclear localization of eEFSec. Publication Status: Online-Only, [RefSeq, PubMed]; Translation factor required for the incorporation of the rare amino acid selenocysteine encoded by UGA codons (PubMed:10970870, PubMed:11265756, PubMed:22992746). Replaces the eRF1-eRF3-GTP ternary complex for the insertion of selenocysteine directed by the UGA codon (PubMed:10970870, PubMed:11265756, PubMed:22992746). Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling (By similarity). (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation (By similarity). (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6GTZ5", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0035368 selenocysteine insertion sequence binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0043021 ribonucleoprotein complex binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0001514 selenocysteine incorporation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JHW4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1N6-1", "uniprot_id": [ { "id": "SFRP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1N6", "type": "external" } ], "mass": 40342.0, "length": 351, "protein_name": "Secreted frizzled-related sequence protein 4", "gene_name": "Sfrp4", "organism": "Mouse", "refseq_name": "secreted frizzled-related sequence protein 4 precursor", "refseq_ac": [ { "id": "NP_057896", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057896", "type": "external" } ], "gene_names_uniprotkb": "Sfrp4", "gene_names_refseq": "Sfrp4", "protein_names_uniprotkb": "Secreted frizzled-related sequence protein 4; FRP-4; sFRP-4", "protein_names_refseq": "FRP-4; frizzled-related protein 4; sFRP-4; secreted frizzled-related sequence protein 4 precursor; secreted frizzled-related sequence protein 4", "tax_id": 10090, "disease": "metaphyseal dysplasia (Disease Ontology:DOID:0080019)", "pathway": " (mmu:20379)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10072424;11485313;12960062;21750661;27355534;35820727;37931101;38411359;9096311;9739103", "class_list": "", "function": "JMJD2A mediates transcriptional activation of SFRP4 and regulates oxidative stress and mitochondrial dysfunction in heart failure., [RefSeq, PubMed]; Sfrp4 is required to maintain Ctsk-lineage periosteal stem cell niche function., [RefSeq, PubMed]; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (PubMed:27355534). SFRP4 plays a role in bone morphogenesis (PubMed:27355534). May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q91ZX9", "ec_number_list": [], "go_molecular_function": "GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0005576 extracellular region", "go_biological_process": "GO:1902174 positive regulation of keratinocyte apoptotic process;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9Z1N6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88974-1", "uniprot_id": [ { "id": "SETB1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88974", "type": "external" } ], "mass": 144549.0, "length": 1307, "protein_name": "Histone-lysine N-methyltransferase SETDB1", "gene_name": "Setdb1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Setdb1; Eset; Kiaa0067", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SETDB1; 2.1.1.366; ERG-associated protein with SET domain; ESET; SET domain bifurcated 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); autistic disorder (Disease Ontology:DOID:12849); Huntington's disease (Disease Ontology:DOID:12858); lung cancer (Disease Ontology:DOID:1324); melanoma (Disease Ontology:DOID:1909); high grade glioma (Disease Ontology:DOID:3070); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:84505); (R-MMU-3214841); (R-MMU-9843940)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "11791185;12398767;14522075;20164836;21183079;21750661;22939622;25428506;25605945;27237050;29728365;30084848;30779550;31112734;32782141;34428180;34887587;36852467;39096901", "class_list": "", "function": "Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) (PubMed:11791185, PubMed:22939622). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones (PubMed:11791185, PubMed:22939622). Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes (PubMed:27237050, PubMed:39096901). H3 'Lys-9' trimethylation is coordinated with DNA methylation (By similarity). Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (By similarity). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (By similarity). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins (By similarity). Required for HUSH-mediated heterochromatin formation and gene silencing (By similarity). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (By similarity). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (By similarity). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (PubMed:20164836, PubMed:27237050, PubMed:29728365). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (By similarity). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (By similarity). Also catalyzes mono- and dimethylation of 'Lys-9' of free histone H3 (H3K9me1 and H3K9me2) during translation in the cytoplasm, which is then transported to the nucleus and incorporated into nucleosomes (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6AXH8;Q78N64;Q78N65;Q80U84;Q8BTV6;Q8CIX7;Q922K1", "ec_number_list": [ { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.366", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.366", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:1990841 promoter-specific chromatin binding;GO:0046974 histone H3K9 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression;GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate;GO:0060348 bone development", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "O88974-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XJV7-1", "uniprot_id": [ { "id": "SETD5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5XJV7", "type": "external" } ], "mass": 157426.0, "length": 1441, "protein_name": "Histone-lysine N-methyltransferase SETD5", "gene_name": "Setd5", "organism": "Mouse", "refseq_name": "histone-lysine N-methyltransferase SETD5 isoform 1", "refseq_ac": [ { "id": "NP_082661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082661", "type": "external" } ], "gene_names_uniprotkb": "Setd5; Kiaa1757", "gene_names_refseq": "2900045N06Rik; C330007C20; Setd5; mKIAA1757", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SETD5; 2.1.1.359; 2.1.1.367; SET domain-containing protein 5", "protein_names_refseq": "SET domain-containing protein 5; histone-lysine N-methyltransferase SETD5 isoform 1; histone-lysine N-methyltransferase SETD5", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 23 (Disease Ontology:DOID:0070053); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748)", "pathway": " (mmu:72895)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "17242355;21183079;22939622;25428506;27864380;30084848;30455454;30655503;30779550;31515109;34428180;36349512;37264456;38857283", "class_list": "", "function": "Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission (PubMed:30455454, PubMed:31515109). May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics (PubMed:31515109). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (PubMed:22939622). The relevance of histone methyltransferase activity is however subject to discussion (PubMed:27864380, PubMed:30455454)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; SETD5 haploinsufficiency affects mitochondrial compartment in neural cells. Publication Status: Online-Only, [RefSeq, PubMed]; Setd5, but not Setd2, is indispensable for retinal cell survival and proliferation., [RefSeq, PubMed]; Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q80T94;Q8BKD5;Q8BX30", "ec_number_list": [ { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.366", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.366", "type": "external" }, { "id": "2.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.372", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" } ], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0046975 histone H3K36 methyltransferase activity;GO:0046974 histone H3K9 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0000791 euchromatin;GO:0034967 Set3 complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0050890 cognition;GO:0006355 regulation of DNA-templated transcription;GO:0051963 regulation of synapse assembly;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q5XJV7-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60520-2", "uniprot_id": [ { "id": "SIN3A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60520", "type": "external" } ], "mass": 145088.0, "length": 1274, "protein_name": "Paired amphipathic helix protein Sin3a", "gene_name": "Sin3a", "organism": "Mouse", "refseq_name": "paired amphipathic helix protein Sin3a isoform 2", "refseq_ac": [ { "id": "NP_001103820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103820", "type": "external" } ], "gene_names_uniprotkb": "Sin3a; Kiaa4126", "gene_names_refseq": "Sin3a; Sin3; mKIAA4126; mSin3A", "protein_names_uniprotkb": "Paired amphipathic helix protein Sin3a; Histone deacetylase complex subunit Sin3a; Transcriptional corepressor Sin3a", "protein_names_refseq": "histone deacetylase complex subunit Sin3a; paired amphipathic helix protein Sin3a isoform 2; paired amphipathic helix protein Sin3a; transcriptional corepressor Sin3a; transcriptional regulator, SIN3 yeast homolog A; transcriptional regulator, SIN3A", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); chromosome 15q24 deletion syndrome (Disease Ontology:DOID:0060395); Huntington's disease (Disease Ontology:DOID:12858); cancer (Disease Ontology:DOID:162); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (mmu:20466); (R-MMU-3899300); (R-MMU-400206); (R-MMU-8936459); (R-MMU-9022692); (R-MMU-9707564); (R-MMU-9824594); (R-MMU-9825892)", "pathway_count": 8, "publication_count": 47, "publication_id_list": "10734093;10950960;11106735;11390640;11882901;11909966;12130660;12198165;12398767;15345747;15774581;16805913;17242355;19144721;20173027;21183079;21454521;21490601;21606357;21680841;22476904;22517741;22826440;23806337;23835259;25402684;25428506;25785643;27399968;28554894;29187734;34428180;34678516;34887587;35944274;36852467;36929576;39627609;40128797;40885482;40997131;7601471;7889570;8521822;8649810;9139820;9702189", "class_list": "", "function": "Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (PubMed:22476904). Required for cortical neuron differentiation and callosal axon elongation (PubMed:27399968)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; An Overfeeding-Induced Obesity Mouse Model Reveals Necessity for Sin3a in Postnatal Peak beta-Cell Mass Acquisition., [RefSeq, PubMed]; The transcriptional regulator Sin3A balances IL-17A and Foxp3 expression in primary CD4 T cells., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q570Z7;Q60820;Q62139;Q62140;Q7TPU8;Q7TSZ2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003714 transcription corepressor activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0017053 transcription repressor complex;GO:0005667 transcription regulator complex", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 5.3, "record_id": "Q60520-2", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TML3-1", "uniprot_id": [ { "id": "S35F2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TML3", "type": "external" } ], "mass": 41635.0, "length": 375, "protein_name": "Queuine/queuosine transporter SLC35F2", "gene_name": "Slc35f2", "organism": "Mouse", "refseq_name": "queuine/queuosine transporter SLC35F2", "refseq_ac": [ { "id": "NP_082336", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082336", "type": "external" } ], "gene_names_uniprotkb": "Slc35f2", "gene_names_refseq": "1500009K05Rik; Slc35f2", "protein_names_uniprotkb": "Queuine/queuosine transporter SLC35F2; Solute carrier family 35 member F2", "protein_names_refseq": "queuine/queuosine transporter SLC35F2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72022)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;25605945;34428180", "class_list": "", "function": "High affinity plasma membrane importer of the nucleobase queuine (q) and its nucleoside queuosine (Q), two bacterially derived micronutrients acquired from the gut microbiome and diet. Following cellular uptake, queuosine is incorporated at the wobble base (position 34) of tRNAs that decode histidine, tyrosine, aspartate, and asparagine codons, which is important for efficient translation. Also involved in choline transport, although the underlying transport mechanism remains to be elucidated (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DB62", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015220 choline transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0015871 choline transport;GO:0160254 tRNA queuosine(34) biosynthetic process from salvaged queuosine or its precursors;GO:0160255 tRNA queuosine(34) biosynthetic process from salvaged queuine", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TML3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQD6-1", "uniprot_id": [ { "id": "SARCO_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQD6", "type": "external" } ], "mass": 3808.0, "length": 31, "protein_name": "Sarcolipin", "gene_name": "Sln", "organism": "Mouse", "refseq_name": "sarcolipin", "refseq_ac": [ { "id": "NP_079816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079816", "type": "external" } ], "gene_names_uniprotkb": "Sln", "gene_names_refseq": "2310045A07Rik; Sln", "protein_names_uniprotkb": "Sarcolipin", "protein_names_refseq": "sarcolipin", "tax_id": 10090, "disease": "", "pathway": " (mmu:66402)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12645548;15201433;15556994;15801907;16036219;21697544;22961106;26816378;27923914;31449798;38564291", "class_list": "", "function": "Improved mitochondrial function in the hearts of sarcolipin-deficient dystrophin and utrophin double-knockout mice. Publication Status: Online-Only, [RefSeq, PubMed]; Retention of sarcolipin in the endoplasmic reticulum is mediated through its association with other components through the C-terminal RSYQY sequence, [RefSeq, PubMed]; Reversibly inhibits the activity of ATP2A1/SERCA1 and ATP2A2/SERCA2 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) (PubMed:21697544, PubMed:22961106, PubMed:26816378, PubMed:31449798). Also inhibits the activity of ATP2A3/SERCA3 (PubMed:27923914). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle (PubMed:21697544, PubMed:26816378). Required for muscle-based, non-shivering thermogenesis (PubMed:22961106)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; SLN overexpression inhibits SERCA2a through stabilization of SERCA2a-phospholamban interaction in the absence of PLN., [RefSeq, PubMed]; Sarcolipin is likely to be an atrial chamber-specific regulator of Ca2+ cycling in heart, [RefSeq, PubMed]; Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008]., [RefSeq]; The expression of SLN and PLB mRNA and protein relative to SERCA1 or SERCA2 was assessed in ventricle, atrium, and skeltal msucle of mouse, rat, rabbit and pig., [RefSeq, PubMed]; We generated left-sided pressure-overload models by transverse aortic constriction (TAC) in ddY mice. TAC significantly decreased the expression of sarcolipin, SERCA2a, and phospholamban mRNAs in the left atrium (LA) than those in the right atrium (RA)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0016529 sarcoplasmic reticulum;GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:1901894 regulation of ATPase-coupled calcium transmembrane transporter activity;GO:1901895 negative regulation of ATPase-coupled calcium transmembrane transporter activity;GO:0051924 regulation of calcium ion transport;GO:0070296 sarcoplasmic reticulum calcium ion transport;GO:1901077 regulation of relaxation of muscle", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CQD6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JI13-1", "uniprot_id": [ { "id": "SAS10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JI13", "type": "external" } ], "mass": 53399.0, "length": 469, "protein_name": "Something about silencing protein 10", "gene_name": "Utp3", "organism": "Mouse", "refseq_name": "something about silencing protein 10", "refseq_ac": [ { "id": "NP_075541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075541", "type": "external" } ], "gene_names_uniprotkb": "Utp3; Crl1; Crlz1; Sas10", "gene_names_refseq": "2400011K09Rik; Crl-1; Crl1; Crlz1; Sas10; Utp3", "protein_names_uniprotkb": "Something about silencing protein 10; Charged amino acid-rich leucine zipper 1; Crl-1; Disrupter of silencing SAS10; UTP3 homolog", "protein_names_refseq": "UTP3 homolog; charged amino acid-rich leucine zipper 1; disrupter of silencing SAS10; something about silencing protein 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:65961); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "11404095;16962668;17015728;19735751;23525569;23806337;24129315;24463520;27226553;31219806;31586036;34428180;36210013", "class_list": "", "function": "Crlz-1, which is induced by canonical Wnt/beta-catenin signaling, controls Germinal Center reaction by regulating the expression of Bcl-6 in centroblasts., [RefSeq, PubMed]; Data show that the cytoplasmic CBFbeta was shown to be mobilized into the nucleus when it was coexpressed with the nuclear Crlz1., [RefSeq, PubMed]; Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Expression of the Crlz-1 gene in mouse testis, [RefSeq, PubMed]; H3 and H4 histones toward the chromatin of the Crlz1 gene are found to be hyperacetylated, especially on H3, in the pre-B cells, whereas those toward the chromatin of the IgJ gene are found to be hyperacetylated in the plasma cells, [RefSeq, PubMed]; Identifies the HSS3/4 enhancer of Crlz1-IgJ locus as another target of EBG in early developmental stage of B cells, [RefSeq, PubMed]; The mechanistic view that the proliferative function of Crlz-1 is caused by relaying Wnt/beta-catenin to pre-B cell receptor signaling pathways through the regulation of Runx/CBFbeta heterodimerization was verified, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UL95;Q8R5C6;Q9JJ12", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:0007420 brain development;GO:0006325 chromatin organization;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9JI13-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FL6-1", "uniprot_id": [ { "id": "SYMC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q68FL6", "type": "external" } ], "mass": 101431.0, "length": 902, "protein_name": "Methionine--tRNA ligase, cytoplasmic", "gene_name": "Mars1", "organism": "Mouse", "refseq_name": "methionine--tRNA ligase, cytoplasmic isoform 2", "refseq_ac": [ { "id": "NP_001003913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003913", "type": "external" } ], "gene_names_uniprotkb": "Mars1; Mars", "gene_names_refseq": "Mars1; Mars; Metrs; Mtrns", "protein_names_uniprotkb": "Methionine--tRNA ligase, cytoplasmic; 6.1.1.10; MetRS; Methionyl-tRNA synthetase", "protein_names_refseq": "methionine tRNA ligase; methionine--tRNA ligase, cytoplasmic isoform 2; methionine--tRNA ligase, cytoplasmic; methionyl-tRNA synthetase, cytoplasmic", "tax_id": 10090, "disease": "nonphotosensitive trichothiodystrophy 9 (Disease Ontology:DOID:0061024); hereditary spastic paraplegia 70 (Disease Ontology:DOID:0070454); Charcot-Marie-Tooth disease axonal type 2U (Disease Ontology:DOID:0110173); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120)", "pathway": " (mmu:216443); (R-MMU-9856649)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;12060739;21183079;21750661;21952136;25428506;26495903;30084848;30779550;31219806;34428180;37828378;39627609;40021952;40885482", "class_list": "", "function": "Catalyzes the specific attachment of L-methionine to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus (By similarity). In addition, can prevent the misincorporation of homocysteine into tRNA and protein by catalyzing a tRNA-independent hydrolysis of the misactivated homocysteinyl-AMP intermediate. The homocysteinyl-AMP intermediate undergoes an intramolecular cyclization reaction in which the thiolate side chain of homocysteine displaces the AMP group, forming homocysteine-thiolactone and AMP (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus., [UniProtKB, UniProtKB]; The encoded protein belongs to the class I family of tRNA synthetases, a class of enzymes that charge tRNAs with their cognate amino acids. The related human gene product is essential for the translation initiation of mRNAs. This gene has an overlapping 3' UTR tail-to-tail arrangement with an adjacent gene on the opposite strand that encodes an inhibitor of the CCAAT/enhancer-binding protein's DNA binding activity. This arrangement, conserved in human and mouse, may be involved in mRNA stability and possible functional and regulatory interaction of these adjacent overlapping genes. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "6.1.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.10", "type": "external" }, { "id": "6.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.4", "type": "external" }, { "id": "6.1.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.18", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "6.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.6", "type": "external" }, { "id": "6.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.19", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0004825 methionine-tRNA ligase activity", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0009303 rRNA transcription;GO:0071364 cellular response to epidermal growth factor stimulus;GO:0036120 cellular response to platelet-derived growth factor stimulus;GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I;GO:0006431 methionyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q68FL6-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CC35-1", "uniprot_id": [ { "id": "SYNPO_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CC35", "type": "external" } ], "mass": 99552.0, "length": 929, "protein_name": "Synaptopodin", "gene_name": "Synpo", "organism": "Mouse", "refseq_name": "synaptopodin isoform B", "refseq_ac": [ { "id": "NP_001103445", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103445", "type": "external" } ], "gene_names_uniprotkb": "Synpo; Kiaa1029", "gene_names_refseq": "9030217H17Rik; 9130229N11; 9330140I15Rik; Synpo", "protein_names_uniprotkb": "Synaptopodin", "protein_names_refseq": "synaptopodin isoform B", "tax_id": 10090, "disease": "chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:104027)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;12357430;12928494;16452087;16452088;17242355;19131326;21183079;21750661;22517741;22645316;24129315;26192747;32848054;33300544;34428180;34678516;35820727;35822049;38247806;38566234;39927985;40021952;40885482;9314539", "class_list": "", "function": "Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity., [UniProtKB, PubMed]; Synaptopodin Regulates Denervation-Induced Plasticity at Hippocampal Mossy Fiber Synapses. Publication Status: Online-Only, [RefSeq, PubMed]; Synaptopodin is required for long-term depression at Schaffer collateral-CA1 synapses. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 19, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 19, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 19, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 22, "binding_glycan_count": 0, "secondary_ac_list": "Q99JI0", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0008542 visual learning;GO:0048169 regulation of long-term neuronal synaptic plasticity;GO:0051492 regulation of stress fiber assembly;GO:0030865 cortical cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 5.1, "record_id": "Q8CC35-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZB0-1", "uniprot_id": [ { "id": "RGS17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZB0", "type": "external" } ], "mass": 24345.0, "length": 210, "protein_name": "Regulator of G protein signaling 17", "gene_name": "Rgs17", "organism": "Mouse", "refseq_name": "regulator of G-protein signaling 17 isoform 1", "refseq_ac": [ { "id": "NP_001155294", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155294", "type": "external" } ], "gene_names_uniprotkb": "Rgs17; Rgsz2", "gene_names_refseq": "6430507P11Rik; Rgs17; Rgsz2", "protein_names_uniprotkb": "Regulator of G protein signaling 17; RGS17; Regulator of Gz-selective protein signaling 2", "protein_names_refseq": "regulator of G-protein signaling 17 isoform 1; regulator of G-protein signaling Z2; regulator of Gz-selective protein signaling 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:56533); (R-MMU-416476); (R-MMU-418594); (R-MMU-418597)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "15827571;16900103;18034455;18652891;21348811;21750661;22163035;31088288", "class_list": "", "function": "Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G proteins., [UniProtKB, UniProtKB, PubMed, PubMed]; SUMO-SIM interactions regulate the activity of RGSZ2 proteins, [RefSeq, PubMed]; These results indicate that the NMDAR/nNOS cascade, activated via MORs, provide the free zinc ions required for inactive PKCgamma to bind to HINT1/RGSZ complex at the C terminus of the receptor., [RefSeq, PubMed]; This RGSZ2-dependent regulation of NMDAR activity is relevant to persistent pain disorders associated with heightened NMDAR-mediated glutamate responses and the reduced antinociceptive capacity of opioids., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543T9", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0043005 neuron projection;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0001975 response to amphetamine;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0009968 negative regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QZB0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQU5-1", "uniprot_id": [ { "id": "SET_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQU5", "type": "external" } ], "mass": 33378.0, "length": 289, "protein_name": "Protein SET", "gene_name": "Set", "organism": "Mouse", "refseq_name": "protein SET isoform 2", "refseq_ac": [ { "id": "NP_001191804", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191804", "type": "external" } ], "gene_names_uniprotkb": "Set", "gene_names_refseq": "2610030F17Rik; 5730420M11Rik; I-2PP2A; Set; StF-IT-1; TAF-I", "protein_names_uniprotkb": "Protein SET; I-2PP2A; Phosphatase 2A inhibitor I2PP2A; TAF-I; Template-activating factor I", "protein_names_refseq": "SET nuclear oncogene; SET translocation; phosphatase 2A inhibitor I2PP2A; protein SET isoform 2; protein SET; template-activating factor I", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 58 (Disease Ontology:DOID:0061032)", "pathway": " (mmu:56086); (R-MMU-2299718); (R-MMU-450520)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "11078917;11231286;17947660;19524510;20668449;21750661;22872234;22872859;23806337;28315936;31219806;31557212;32152506;33296674;33725478;34428180;35728284;36210013;37453647", "class_list": "", "function": "Co-immunofluorescent staining of mouse gastrointestinal tissues revealed that even though the positive rate is much lower than epithelial cells, SET protein is also expressed in non-epithelial cells, such as monocytes/macrophages, neural cells, myofibroblasts, and smooth muscle cells. Results indicate an extensive role of SET in a variety of cell types. Publication Status: Online-Only, [RefSeq, PubMed]; Embryonic Stem Cell Differentiation Is Regulated by SET through Interactions with p53 and beta-Catenin., [RefSeq, PubMed]; Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; SET improved oocyte maturation by serine/threonine protein phosphatase 2A and inhibited oocyte apoptosis in mouse oocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BE95;Q9CY82;Q9D0A9;Q9Z181", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet", "go_biological_process": "GO:0045892 negative regulation of DNA-templated transcription;GO:0043524 negative regulation of neuron apoptotic process;GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9EQU5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQV1-1", "uniprot_id": [ { "id": "TIM16_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQV1", "type": "external" } ], "mass": 13785.0, "length": 125, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM16", "gene_name": "Pam16l; Pam16", "organism": "Mouse", "refseq_name": "mitochondrial import inner membrane translocase subunit TIM16", "refseq_ac": [ { "id": "NP_079847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079847", "type": "external" } ], "gene_names_uniprotkb": "Pam16l; Pam16; Magmas; Tim16; Timm16", "gene_names_refseq": "2010110I09Rik; CGI-136; Magmas; Pam16; Tim16; Timm16", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM16; Mitochondria-associated granulocyte macrophage CSF-signaling molecule; Presequence translocated-associated motor subunit PAM16", "protein_names_refseq": "magmas processed gene 1; mitochondria associated granulocyte macrophage CSF signaling molecule; mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction; mitochondrial import inner membrane translocase subunit TIM16; presequence translocase-asssociated motor 16 homolog; presequence translocated-associated motor subunit PAM16", "tax_id": 10090, "disease": "spondylometaphyseal dysplasia Megarbane-Dagher-Melike type (Disease Ontology:DOID:0112304); osteochondrodysplasia (Disease Ontology:DOID:2256)", "pathway": " (mmu:66449)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11750097;15984936;21183079;21750661;24786642;24856930", "class_list": "", "function": "Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6EIX1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005744 TIM23 mitochondrial import inner membrane translocase complex;GO:0001405 PAM complex, Tim23 associated import motor", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0001503 ossification;GO:2001234 negative regulation of apoptotic signaling pathway;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CQV1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P5E6-1", "uniprot_id": [ { "id": "GGA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P5E6", "type": "external" } ], "mass": 66049.0, "length": 603, "protein_name": "ADP-ribosylation factor-binding protein GGA2", "gene_name": "Gga2", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor-binding protein GGA2", "refseq_ac": [ { "id": "NP_083034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083034", "type": "external" } ], "gene_names_uniprotkb": "Gga2; Kiaa1080", "gene_names_refseq": "1200007E24Rik; Gga2; mKIAA1080", "protein_names_uniprotkb": "ADP-ribosylation factor-binding protein GGA2; Gamma-adaptin-related protein 2; Golgi-localized, gamma ear-containing, ARF-binding protein 2", "protein_names_refseq": "ADP-ribosylation factor-binding protein GGA2; gamma-adaptin-related protein 2; golgi-localized, gamma ear-containing, ARF-binding protein 2", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); lysosomal storage disease (Disease Ontology:DOID:3211)", "pathway": " (mmu:74105)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11950392;19864490;22762444;25153642;26495903;31219806;36210013", "class_list": "", "function": "GGA2 binds to the internal DXXLL motif of the LRP9, [RefSeq, PubMed]; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U374;Q6PFX3;Q6ZPY8;Q8BM76;Q9DC15", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0035091 phosphatidylinositol binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0031901 early endosome membrane;GO:0030136 clathrin-coated vesicle;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0043001 Golgi to plasma membrane protein transport;GO:0034394 protein localization to cell surface;GO:0006893 Golgi to plasma membrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6P5E6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70392-1", "uniprot_id": [ { "id": "RGRF2_MOUSE", "url": "https://www.uniprot.org/uniprot/P70392", "type": "external" } ], "mass": 135668.0, "length": 1189, "protein_name": "Ras-specific guanine nucleotide-releasing factor 2", "gene_name": "Rasgrf2", "organism": "Mouse", "refseq_name": "ras-specific guanine nucleotide-releasing factor 2", "refseq_ac": [ { "id": "NP_033053", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033053", "type": "external" } ], "gene_names_uniprotkb": "Rasgrf2; Grf2", "gene_names_refseq": "6330417G04Rik; Grf2; Ras-GRF2; Rasgrf2", "protein_names_uniprotkb": "Ras-specific guanine nucleotide-releasing factor 2; Ras guanine nucleotide exchange factor 2; Ras-GRF2", "protein_names_refseq": "ras guanine nucleotide exchange factor 2; ras-specific guanine nucleotide-releasing factor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:19418); (R-MMU-193648); (R-MMU-416482); (R-MMU-5673001); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 7, "publication_count": 23, "publication_id_list": "10373510;10733575;11238945;11500499;11856323;11909944;14749369;15029245;15128856;16407208;16467520;16649990;21183079;21750661;22517741;22645316;30016717;30084848;34428180;40021952;40885482;9032266;9707409", "class_list": "", "function": "Data show that Ras-GRF1 and Ras-GRF2 couple NMDA glutamate receptors to the activation of the Ras/Erk signaling cascade and to the maintenance of CREB transcription factor activity in cortical neurons of adult mice., [RefSeq, PubMed]; Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3TYN3;Q9QX51", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0098794 postsynapse", "go_biological_process": "GO:2000310 regulation of NMDA receptor activity;GO:0007265 Ras protein signal transduction;GO:0060291 long-term synaptic potentiation;GO:0034976 response to endoplasmic reticulum stress;GO:0099170 postsynaptic modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P70392-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TT28-1", "uniprot_id": [ { "id": "REXO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TT28", "type": "external" } ], "mass": 130790.0, "length": 1213, "protein_name": "RNA exonuclease 1 homolog", "gene_name": "Rexo1", "organism": "Mouse", "refseq_name": "RNA exonuclease 1 homolog", "refseq_ac": [ { "id": "NP_080128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080128", "type": "external" } ], "gene_names_uniprotkb": "Rexo1; Kiaa1138; Tceb3bp1", "gene_names_refseq": "1700021P10Rik; 2610511M11Rik; EloA-BP1; Rex1; Rexo1; Tceb3bp1", "protein_names_uniprotkb": "RNA exonuclease 1 homolog; 3.1.-.-; Transcription elongation factor B polypeptide 3-binding protein 1", "protein_names_refseq": "REX1, RNA exonuclease 1 homolog; RNA exonuclease 1 homolog; elongin A binding protein 1; transcription elongation factor B polypeptide 3 binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66932)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21750661;31219806;34428180;35820727", "class_list": "", "function": "Seems to have no detectable effect on transcription elongation in vitro., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMP1;Q69ZR0;Q6NSQ6;Q6PI95;Q9DA29", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0004527 exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0031125 rRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7TT28-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61329-1", "uniprot_id": [ { "id": "ZFHX3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61329", "type": "external" } ], "mass": 406570.0, "length": 3726, "protein_name": "Zinc finger homeobox protein 3", "gene_name": "Zfhx3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zfhx3; Atbf1", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger homeobox protein 3; AT motif-binding factor 1; AT-binding transcription factor 1; Alpha-fetoprotein enhancer-binding protein; ZFH-3; Zinc finger homeodomain protein 3", "protein_names_refseq": "", "tax_id": 10090, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); spinocerebellar ataxia 4 (Disease Ontology:DOID:0050957); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); autoimmune hepatitis (Disease Ontology:DOID:2048); mucinous adenocarcinoma (Disease Ontology:DOID:3030); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); cervical cancer (Disease Ontology:DOID:4362); tubular adenocarcinoma (Disease Ontology:DOID:4929); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); colorectal cancer (Disease Ontology:DOID:9256); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11906); (R-MMU-8941855)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "11312261;18299400;21183079;21606357;21750661;21952136;22872234;23022192;26232227;31219806;32782141;34428180;36852467;37449401;40997131;8654949;9171351", "class_list": "", "function": "Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (By similarity). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (PubMed:26232227). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer. In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 15, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0016604 nuclear body", "go_biological_process": "GO:1904059 regulation of locomotor rhythm;GO:0071559 response to transforming growth factor beta;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q61329-1", "record_type": "protein", "filter_code": "0000000.1100111.001000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97493-1", "uniprot_id": [ { "id": "THIOM_MOUSE", "url": "https://www.uniprot.org/uniprot/P97493", "type": "external" } ], "mass": 18255.0, "length": 166, "protein_name": "Thioredoxin, mitochondrial", "gene_name": "Txn2", "organism": "Mouse", "refseq_name": "thioredoxin, mitochondrial precursor", "refseq_ac": [ { "id": "NP_064297", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064297", "type": "external" } ], "gene_names_uniprotkb": "Txn2", "gene_names_refseq": "2510006J11Rik; Trx2; Txn2", "protein_names_uniprotkb": "Thioredoxin, mitochondrial; MTRX; Mt-Trx; Thioredoxin-2", "protein_names_refseq": "MTRX; mt-Trx; thioredoxin nuclear gene encoding mitochondrial protein; thioredoxin, mitochondrial precursor; thioredoxin, mitochondrial", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 29 (Disease Ontology:DOID:0111501)", "pathway": " (mmu:56551); (R-MMU-1614558); (R-MMU-3299685)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "12529397;21750661;23806337;31219806;34428180;35202005;38003443;38349408", "class_list": "", "function": "Brown adipose TRX2 deficiency activates mtDNA-NLRP3 to impair thermogenesis and protect against diet-induced insulin resistance., [RefSeq, PubMed]; Homozygous mutant embryos do not survive to birth and die after implantation at Theiler stage 15/16., [RefSeq, PubMed]; Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Is involved in various redox reactions including the reduction of protein disulfide bonds, through the reversible oxidation of its active center dithiol to a disulfide., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; ScAAV2-Mediated Expression of Thioredoxin 2 and C3 Transferase Prevents Retinal Ganglion Cell Death and Lowers Intraocular Pressure in a Mouse Model of Glaucoma. Publication Status: Online-Only, [RefSeq, PubMed]; Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A440;Q545D5", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0015035 protein-disulfide reductase activity;GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor", "go_cellular_component": "GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P97493-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2C8-1", "uniprot_id": [ { "id": "YBOX2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2C8", "type": "external" } ], "mass": 38271.0, "length": 360, "protein_name": "Y-box-binding protein 2", "gene_name": "Ybx2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ybx2; Msy2", "gene_names_refseq": "", "protein_names_uniprotkb": "Y-box-binding protein 2; FRGY2 homolog; Germ cell-specific Y-box-binding protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:53422)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10076007;10772793;11564883;11566752;12297523;12648488;15031116;15665108;15824319;21183079;21750661;31598710;37507081;9780336", "class_list": "", "function": "Major constituent of messenger ribonucleoprotein particles (mRNPs) (PubMed:10076007, PubMed:12297523, PubMed:12648488). Involved in the regulation of the stability and/or translation of germ cell mRNAs (PubMed:15031116). Binds to Y-box consensus promoter element (PubMed:10076007, PubMed:12297523, PubMed:12648488). Binds to full-length mRNA with high affinity in a sequence-independent manner (PubMed:10076007, PubMed:12297523, PubMed:12648488). Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity (PubMed:10076007, PubMed:12297523, PubMed:12648488). Its binding with maternal mRNAs is necessary for its cytoplasmic retention (PubMed:10076007, PubMed:12297523, PubMed:12648488). May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (PubMed:15665108)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5NCW8;Q5NCW9;Q9Z2C7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003729 mRNA binding;GO:0043021 ribonucleoprotein complex binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0048255 mRNA stabilization;GO:0007286 spermatid development;GO:0017148 negative regulation of translation;GO:0010468 regulation of gene expression;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9Z2C8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BU31-1", "uniprot_id": [ { "id": "RAP2C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BU31", "type": "external" } ], "mass": 20745.0, "length": 183, "protein_name": "Ras-related protein Rap-2c", "gene_name": "Rap2c", "organism": "Mouse", "refseq_name": "ras-related protein Rap-2c", "refseq_ac": [ { "id": "NP_766001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766001", "type": "external" } ], "gene_names_uniprotkb": "Rap2c", "gene_names_refseq": "2010200P20Rik; Rap2c", "protein_names_uniprotkb": "Ras-related protein Rap-2c; 3.6.5.2", "protein_names_refseq": "ras-related protein Rap-2c", "tax_id": 10090, "disease": "", "pathway": " (mmu:72065); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "19061864;28714326;29457987;33300544;37828378", "class_list": "", "function": "Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription., [UniProtKB, PubMed]; Study found that SCII upregulated the expression of miR-204 and downregulated the expression of RAP2C; that hypoxia increased the expression of miR-204 and decreased the expression of RAP2C, and overexpression of RAP2C attenuates the effect of hypoxia on apoptosis rate; and miR-204 could directly bind to RAP2C, and could regulate the expression of RAP2C., [RefSeq, PubMed]; The Rap2c GTPase facilitates B cell receptor-induced reorientation of the microtubule-organizing center., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q504Q0;Q6P1Y7;Q810J4;Q8R2P4", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.3.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.78", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016020 membrane", "go_biological_process": "GO:0032486 Rap protein signal transduction;GO:0030336 negative regulation of cell migration;GO:0090557 establishment of endothelial intestinal barrier;GO:0031954 positive regulation of protein autophosphorylation;GO:0061097 regulation of protein tyrosine kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BU31-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQE5-1", "uniprot_id": [ { "id": "RGS10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQE5", "type": "external" } ], "mass": 21151.0, "length": 181, "protein_name": "Regulator of G protein signaling 10", "gene_name": "Rgs10", "organism": "Mouse", "refseq_name": "regulator of G-protein signaling 10 isoform 1", "refseq_ac": [ { "id": "NP_080694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080694", "type": "external" } ], "gene_names_uniprotkb": "Rgs10", "gene_names_refseq": "2310010N19Rik; Rgs10", "protein_names_uniprotkb": "Regulator of G protein signaling 10; RGS10", "protein_names_refseq": "regulator of G-protein signaling 10 isoform 1; regulator of G-protein signaling 10", "tax_id": 10090, "disease": "opioid abuse (Disease Ontology:DOID:11206)", "pathway": " (mmu:67865)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21750661;34428180;36041584;37092953;37879890", "class_list": "", "function": "Inhibition of RGS10 Aggravates Periapical Periodontitis via Upregulation of the NF-kappaB Pathway., [RefSeq, PubMed]; RGS10 inhibits proliferation and migration of pulmonary arterial smooth muscle cell in pulmonary hypertension via AKT/mTORC1 signaling., [RefSeq, PubMed]; RGS10 negatively regulates apical periodontitis via TFEB-mediated autophagy in BABL/c mice model and in vitro., [RefSeq, PubMed]; Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to CHRM2 signaling. Activity on GNAZ is inhibited by palmitoylation of the G protein., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D3L2", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0043197 dendritic spine", "go_biological_process": "GO:0007213 G protein-coupled acetylcholine receptor signaling pathway;GO:0043547 positive regulation of GTPase activity;GO:0009968 negative regulation of signal transduction;GO:0008277 regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CQE5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97492-1", "uniprot_id": [ { "id": "RGS14_MOUSE", "url": "https://www.uniprot.org/uniprot/P97492", "type": "external" } ], "mass": 59847.0, "length": 547, "protein_name": "Regulator of G protein signaling 14", "gene_name": "Rgs14", "organism": "Mouse", "refseq_name": "regulator of G-protein signaling 14 isoform 1", "refseq_ac": [ { "id": "NP_058038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058038", "type": "external" } ], "gene_names_uniprotkb": "Rgs14", "gene_names_refseq": "RPIP1; Rgs14", "protein_names_uniprotkb": "Regulator of G protein signaling 14; RAP1/RAP2-interacting protein; RGS14; RPIP1", "protein_names_refseq": "RAP1/RAP2-interacting protein; rap1/rap2 interacting protein; regulator of G-protein signaling 14 isoform 1", "tax_id": 10090, "disease": "nephrolithiasis (Disease Ontology:DOID:585)", "pathway": " (mmu:51791); (R-MMU-418594)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10926822;15112653;15337739;15520006;15525537;15917656;16246175;17635935;20837545;21158412;21183079;21750661;25605945;29414686;34455616;36905127;36971428;37075948;40684658", "class_list": "", "function": "Exercise enhancement by RGS14 disruption is mediated by brown adipose tissue., [RefSeq, PubMed]; Mechanisms of mGluR-dependent plasticity in hippocampal area CA2., [RefSeq, PubMed]; RGS14 limits seizure-induced mitochondrial oxidative stress and pathology in hippocampus., [RefSeq, PubMed]; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3 (PubMed:29414686). May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerization and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division; required for completion of the first mitotic division of the embryo. Involved in visual memory processing capacity; when overexpressed in the V2 secondary visual cortex area. Involved in hippocampal-based learning and memory; acts as a suppressor of synaptic plasticity in CA2 neurons. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Regulator of G-protein signaling 14 protects the liver from ischemia-reperfusion injury by suppressing TGF-beta-activated kinase 1 activation., [RefSeq, PubMed]; The RGS14 GoLoco domain discriminates among Galphai isoforms, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K2R4;Q9DCD1", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0001965 G-protein alpha-subunit binding;GO:0032794 GTPase activating protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006913 nucleocytoplasmic transport;GO:0006979 response to oxidative stress;GO:0007059 chromosome segregation;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P97492-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PFX8-1", "uniprot_id": [ { "id": "RIMKA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PFX8", "type": "external" } ], "mass": 41504.0, "length": 380, "protein_name": "N-acetylaspartylglutamate synthase A", "gene_name": "Rimkla", "organism": "Mouse", "refseq_name": "N-acetylaspartylglutamate synthase A", "refseq_ac": [ { "id": "NP_808240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808240", "type": "external" } ], "gene_names_uniprotkb": "Rimkla; Fam80a; Rimk", "gene_names_refseq": "B930030J24; NAAGS-II; NAAGS; Rimkla; Rimk", "protein_names_uniprotkb": "N-acetylaspartylglutamate synthase A; 6.3.2.41; 6.3.2.42; N-acetylaspartylglutamylglutamate synthase A; NAAG synthetase A; NAAGS; Ribosomal protein S6 modification-like protein A", "protein_names_refseq": "N-acetylaspartyl-glutamate synthetase A; N-acetylaspartylglutamate synthase A; N-acetylaspartylglutamylglutamate synthase A; NAAG synthetase A; ribosomal protein S6 modification-like protein A", "tax_id": 10090, "disease": "", "pathway": " (mmu:194237); (R-MMU-8964539)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "20657015;21183079;21454531;39117631", "class_list": "", "function": "Catalyzes the synthesis of N-acetyl-L-aspartyl-L-glutamate (NAAG) and N-acetyl-L-aspartyl-L-glutamyl-L-glutamate., [UniProtKB, PubMed, PubMed]; Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase., [RefSeq, PubMed]; Ribosomal modification protein rimK-like family member A (Rimkla) gene is a NAAG synthetase (NAAGS-II), which synthesizes the N-acetylated tripeptide N-acetylaspartylglutamylglutamate (NAAG(2)), [RefSeq, PubMed]; Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis. Erratum:[Signal Transduct Target Ther. 2024 Dec 11;9(1):360. doi: 10.1038/s41392-024-02054-1. PMID: 39663370] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BXH0", "ec_number_list": [ { "id": "6.3.2.41", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.41", "type": "external" }, { "id": "6.3.2.42", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.42", "type": "external" }, { "id": "6.3.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.17", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PFX8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QI06-1", "uniprot_id": [ { "id": "RICTR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6QI06", "type": "external" } ], "mass": 191570.0, "length": 1708, "protein_name": "Rapamycin-insensitive companion of mTOR", "gene_name": "Rictor", "organism": "Mouse", "refseq_name": "rapamycin-insensitive companion of mTOR", "refseq_ac": [ { "id": "NP_084444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084444", "type": "external" } ], "gene_names_uniprotkb": "Rictor; Kiaa1999", "gene_names_refseq": "4921505C17Rik; 6030405M08Rik; AVO3; D530039E11Rik; Rictor", "protein_names_uniprotkb": "Rapamycin-insensitive companion of mTOR; AVO3 homolog; Protein pianissimo; mAVO3", "protein_names_refseq": "AVO3 homolog; mAVO3; protein pianissimo; rapamycin-insensitive companion of mTOR", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); colon cancer (Disease Ontology:DOID:219); breast ductal carcinoma (Disease Ontology:DOID:3007); gallbladder cancer (Disease Ontology:DOID:3121); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung small cell carcinoma (Disease Ontology:DOID:5409); hepatocellular carcinoma (Disease Ontology:DOID:684); tongue cancer (Disease Ontology:DOID:8649); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:78757); (R-MMU-1257604); (R-MMU-389357); (R-MMU-5218920); (R-MMU-6804757); (R-MMU-9856530)", "pathway_count": 6, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;15467718;16221682;16962653;16962829;17141160;21183079;21952136;23142081;23388827;24670654;25418727;25428506;25605945;29232555;30084848;30779550;33294856;33378666;33850054;34428180;35820727;37828378", "class_list": "", "function": "Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:16221682, PubMed:16962653, PubMed:17141160, PubMed:24670654, PubMed:29232555, PubMed:33850054). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:16221682, PubMed:16962653, PubMed:17141160, PubMed:24670654, PubMed:33850054). In contrast to mTORC1, mTORC2 is nutrient-insensitive (By similarity). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (By similarity). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (By similarity). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:16221682, PubMed:16962653, PubMed:17141160). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (PubMed:33850054). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (PubMed:23142081, PubMed:23388827). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (By similarity). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (By similarity). Plays an essential role in embryonic growth and development (PubMed:16962829)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 30, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 12, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QPE0;Q0VAV4;Q69Z40;Q6PDL2;Q6RI74;Q8BPH9;Q8CBF2", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:1902554 serine/threonine protein kinase complex;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0009792 embryo development ending in birth or egg hatching;GO:0008610 lipid biosynthetic process;GO:0030307 positive regulation of cell growth;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q6QI06-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCD6-1", "uniprot_id": [ { "id": "REEP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCD6", "type": "external" } ], "mass": 28437.0, "length": 254, "protein_name": "Receptor expression-enhancing protein 2", "gene_name": "Reep2", "organism": "Mouse", "refseq_name": "receptor expression-enhancing protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001191843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191843", "type": "external" } ], "gene_names_uniprotkb": "Reep2", "gene_names_refseq": "Reep2", "protein_names_uniprotkb": "Receptor expression-enhancing protein 2", "protein_names_refseq": "receptor expression-enhancing protein 2 isoform 2; receptor expression-enhancing protein 2", "tax_id": 10090, "disease": "hereditary spastic paraplegia 72B (Disease Ontology:DOID:0070642); hereditary spastic paraplegia 31 (Disease Ontology:DOID:0110782); hereditary spastic paraplegia 72A (Disease Ontology:DOID:0110817)", "pathway": " (mmu:225362)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15550249;20943918;21183079;25428506;34428180", "class_list": "", "function": "REEP2 recruits sweet receptors into lipid raft microdomains localized near the taste cell's apical region, thereby improving G-protein-coupled receptor signaling and promoting receptor access to tastants arriving through the apical taste pore., [RefSeq, PubMed]; Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0031883 taste receptor binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005881 cytoplasmic microtubule;GO:0071782 endoplasmic reticulum tubular network", "go_biological_process": "GO:0032386 regulation of intracellular transport;GO:0071786 endoplasmic reticulum tubular network organization;GO:0032596 protein transport into membrane raft;GO:0050913 sensory perception of bitter taste;GO:0050916 sensory perception of sweet taste", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VCD6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBU3-1", "uniprot_id": [ { "id": "RIOK3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBU3", "type": "external" } ], "mass": 58704.0, "length": 519, "protein_name": "Serine/threonine-protein kinase RIO3", "gene_name": "Riok3", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase RIO3", "refseq_ac": [ { "id": "NP_077144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077144", "type": "external" } ], "gene_names_uniprotkb": "Riok3", "gene_names_refseq": "1200013N13Rik; D18Ertd331e; E130306C24Rik; Riok3; Sudd", "protein_names_uniprotkb": "Serine/threonine-protein kinase RIO3; 2.7.11.1; RIO kinase 3", "protein_names_refseq": "serine/threonine-protein kinase RIO3; sudD, suppressor of bimD6 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66878); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "18630941;21183079;21196494;21750661;25428506;25605945;28315936;30084848;34161773;34428180;37866658", "class_list": "", "function": "Down-regulation of miR-191 is essential for erythroid chromatin condensation and enucleation by allowing up-regulation of Riok3 and Mxi1, [RefSeq, PubMed]; RIOK3 potentially regulates osteogenesis-related pathways in ankylosing spondylitis and the differentiation of bone marrow mesenchymal stem cells., [RefSeq, PubMed]; Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation., [RefSeq, PubMed]; Serine/threonine-protein kinase involved in a ribosome quality control that takes place when ribosomes have stalled, leading to 18S non-functional rRNA decay and degradation of the 40S ribosomal subunit. Acts downstream of RNF10: specifically recognizes and binds RPS2/us5 and RPS3/us3 monoubiquitinated by RNF10, promoting degradation of the 40S ribosomal subunit in a kinase-dependent manner. The RNF10-RIOK3 ribosome quality control takes place in response to ribosome subunit imbalance or downstream the EIF2AK4/GCN2-mediated integrated stress response (ISR). Also involved in regulation of type I interferon (IFN)-dependent immune response, possibly by acting as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7-mediated activation of the NF-kappa-B signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UI51;Q8CIC1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0089720 caspase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0022626 cytosolic ribosome;GO:0030688 preribosome, small subunit precursor", "go_biological_process": "GO:0071359 cellular response to dsRNA;GO:0070651 nonfunctional rRNA decay;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0043124 negative regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9DBU3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1M8-1", "uniprot_id": [ { "id": "RED_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1M8", "type": "external" } ], "mass": 65616.0, "length": 557, "protein_name": "Protein Red", "gene_name": "Ik", "organism": "Mouse", "refseq_name": "protein Red", "refseq_ac": [ { "id": "NP_036009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036009", "type": "external" } ], "gene_names_uniprotkb": "Ik; Red; Rer", "gene_names_refseq": "Ik; MuRED", "protein_names_uniprotkb": "Protein Red; Cytokine IK; IK factor; Protein RER", "protein_names_refseq": "IK factor; arginine/glutamic acid/aspartic acid repeat containing protein; cytokine IK; protein Red", "tax_id": 10090, "disease": "", "pathway": " (mmu:24010); (R-MMU-72163)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10216252;16452087;21183079;21750661;23409929;23806337;24996188;25428506;25605945;28071693;30084848;34428180", "class_list": "", "function": "IK is an essential protein for achieving correct mitotic progress through the regulation of mitotic kinases and phosphatases, [RefSeq, PubMed]; Involved in pre-mRNA splicing as a component of the spliceosome. Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species. Required for normal mitotic cell cycle progression. Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint. Required for normal accumulation of SMU1., [UniProtKB, UniProtKB]; Our observations suggest that tIK cytokine can counterbalance the induction of inflammatory cells related to rheumatoid arthritis(RA) and thus could be a new therapeutic agent for the treatment of RA. Publication Status: Online-Only, [RefSeq, PubMed]; Taken together, these results imply that IK plays a role in downregulating MHC class II expression on B cells during coxsackievirus B3 infection through the induction of cAMP., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0P0;Q95H93", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005694 chromosome", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0000398 mRNA splicing, via spliceosome;GO:0034501 protein localization to kinetochore", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9Z1M8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31648-1", "uniprot_id": [ { "id": "SC6A1_MOUSE", "url": "https://www.uniprot.org/uniprot/P31648", "type": "external" } ], "mass": 67001.0, "length": 599, "protein_name": "Sodium- and chloride-dependent GABA transporter 1", "gene_name": "Slc6a1", "organism": "Mouse", "refseq_name": "sodium- and chloride-dependent GABA transporter 1", "refseq_ac": [ { "id": "NP_848818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848818", "type": "external" } ], "gene_names_uniprotkb": "Slc6a1; Gabt1; Gat-1; Gat1", "gene_names_refseq": "A730043E01; GABATHG; GABATR; GAT-1; Gabt1; Gabt; Gat1; Slc6a1; XT-1; Xtrp1", "protein_names_uniprotkb": "Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1", "protein_names_refseq": "gamma-aminobutyric acid (GABA-A) transporter 1; sodium- and chloride-dependent GABA transporter 1; solute carrier family 6 member 1", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); epilepsy (Disease Ontology:DOID:1826); brain ischemia (Disease Ontology:DOID:2316); temporal lobe epilepsy (Disease Ontology:DOID:3328); cerebral infarction (Disease Ontology:DOID:3526); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:232333); (R-MMU-442660); (R-MMU-888593)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "15234345;16150932;1631167;21183079;21750661;30270321;31219806;33300544;8420981;9858742", "class_list": "", "function": "Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:15234345, PubMed:16150932, PubMed:30270321, PubMed:8420981). The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (By similarity). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (By similarity). Can also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA (PubMed:30270321)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 3, "mined_n_glycosites": 3, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005332 gamma-aminobutyric acid:sodium:chloride symporter activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005283 amino acid:sodium symporter activity;GO:0015378 sodium:chloride symporter activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007612 learning;GO:0007613 memory;GO:0008306 associative learning;GO:0014074 response to purine-containing compound;GO:0050808 synapse organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P31648-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100100000001.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62267-1", "uniprot_id": [ { "id": "RS23_MOUSE", "url": "https://www.uniprot.org/uniprot/P62267", "type": "external" } ], "mass": 15808.0, "length": 143, "protein_name": "Small ribosomal subunit protein uS12", "gene_name": "Rps23", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS12", "refseq_ac": [ { "id": "NP_077137", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077137", "type": "external" } ], "gene_names_uniprotkb": "Rps23", "gene_names_refseq": "2410044J15Rik; Rps23", "protein_names_uniprotkb": "Small ribosomal subunit protein uS12; 40S ribosomal protein S23", "protein_names_refseq": "40S ribosomal protein S23; small ribosomal subunit protein uS12", "tax_id": 10090, "disease": "brachycephaly, trichomegaly, and developmental delay (Disease Ontology:DOID:0070415)", "pathway": " (mmu:66475); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-9629569); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 14, "publication_count": 14, "publication_id_list": "20650958;23806337;25428506;28011936;29125738;31219806;33725478;34428180;35820727;35984892;36517592;37453647;37507081;39627609", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:36517592). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:36517592). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:36517592). Plays an important role in translational accuracy (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, PubMed]; Retroposition of Rps23 mRNA occurred multiple times in different species but only generated another functionally expressed Rps23rg1-homologous gene, Rps23rg2, in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P39028;Q542K7", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005791 rough endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0006412 translation;GO:0034063 stress granule assembly;GO:1990145 maintenance of translational fidelity;GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P62267-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TPM5-1", "uniprot_id": [ { "id": "SACA9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TPM5", "type": "external" } ], "mass": 19482.0, "length": 168, "protein_name": "Sperm acrosome-associated protein 9", "gene_name": "Spaca9", "organism": "Mouse", "refseq_name": "sperm acrosome-associated protein 9", "refseq_ac": [ { "id": "NP_081559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081559", "type": "external" } ], "gene_names_uniprotkb": "Spaca9", "gene_names_refseq": "1700026L06Rik; MAST; Spaca9", "protein_names_uniprotkb": "Sperm acrosome-associated protein 9; Acrosome and sperm tail protein; MAST", "protein_names_refseq": "acrosome and sperm tail protein; sperm acrosome-associated protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:69987)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "24256100;27914912;37865089;37989994", "class_list": "", "function": "Identified a mouse acrosomal protein, MAST, that is expressed testis specifically. MAST does not contain any known motifs for protein interactions; yet it complexes with calcium-binding proteins localizing to the acrosome. Publication Status: Online-Only, [RefSeq, PubMed]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) of multiciliated respiratory cells and the distal singlet microtubules of monoflagellated spermatozoa (PubMed:37865089, PubMed:37989994). Forms an extensive interaction network cross-linking the lumen of axonemal doublet microtubules (PubMed:37865089)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTJ0;Q3U293;Q9D9W4", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0048306 calcium-dependent protein binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0035082 axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7TPM5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C3K6-1", "uniprot_id": [ { "id": "SC5A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C3K6", "type": "external" } ], "mass": 73449.0, "length": 665, "protein_name": "Sodium/glucose cotransporter 1", "gene_name": "Slc5a1", "organism": "Mouse", "refseq_name": "sodium/glucose cotransporter 1", "refseq_ac": [ { "id": "NP_062784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062784", "type": "external" } ], "gene_names_uniprotkb": "Slc5a1; Nagt; Sglt1", "gene_names_refseq": "Sglt1; Slc5a1", "protein_names_uniprotkb": "Sodium/glucose cotransporter 1; High affinity sodium-glucose cotransporter; Na(+)/glucose cotransporter 1; Solute carrier family 5 member 1", "protein_names_refseq": "Na(+)/glucose cotransporter 1; high affinity sodium-glucose cotransporter; sodium/glucose cotransporter 1; solute carrier family 5, member 1; solute carrier family 5, member alpha 1", "tax_id": 10090, "disease": "glucose-galactose malabsorption (Disease Ontology:DOID:0070563)", "pathway": " (mmu:20537); (R-MMU-189200); (R-MMU-8981373)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;21183079;22124465;28974690;30084848;34428180;37350393;38282316;38308715", "class_list": "glycogene", "function": "Deletion of the Sodium Glucose Cotransporter 1 (Sglt-1) impairs mouse sperm movement., [RefSeq, PubMed]; Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:22124465, PubMed:28974690). Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis (PubMed:22124465). Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules (PubMed:22124465). Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception (PubMed:28974690). Acts as a water channel enabling passive water transport in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity comparable to aquaporins and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine., [UniProtKB, UniProtKB, PubMed, PubMed]; Increased intestinal permeability and downregulation of absorptive ion transporters Nhe3, Dra, and Sglt1 contribute to diarrhea during Clostridioides difficile infection., [RefSeq, PubMed]; Involvement of sodium-glucose cotransporter-1 activities in maintaining oscillatory Cl[-] currents from mouse submandibular acinar cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005412 D-glucose:sodium symporter activity;GO:0005372 water transmembrane transporter activity;GO:0055056 D-glucose transmembrane transporter activity;GO:0015371 galactose:sodium symporter activity;GO:0015151 alpha-glucoside transmembrane transporter activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0005911 cell-cell junction", "go_biological_process": "GO:0035623 renal D-glucose absorption;GO:1904659 D-glucose transmembrane transport;GO:0001951 intestinal D-glucose absorption;GO:0050892 intestinal absorption;GO:0001656 metanephros development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8C3K6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.100.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VBW1-2", "uniprot_id": [ { "id": "SC6A8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VBW1", "type": "external" } ], "mass": 70571.0, "length": 635, "protein_name": "Sodium- and chloride-dependent creatine transporter 1", "gene_name": "Slc6a8", "organism": "Mouse", "refseq_name": "sodium- and chloride-dependent creatine transporter 1 isoform 2", "refseq_ac": [ { "id": "NP_001136281", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136281", "type": "external" } ], "gene_names_uniprotkb": "Slc6a8; Crt", "gene_names_refseq": "CRTR; CRT; CT1; CTR5; Creat; Slc6a8", "protein_names_uniprotkb": "Sodium- and chloride-dependent creatine transporter 1; CT1; Creatine transporter 1; Solute carrier family 6 member 8", "protein_names_refseq": "creatine transporter, solute carrier family 6, member 8; sodium- and chloride-dependent creatine transporter 1 isoform 2; sodium- and chloride-dependent creatine transporter 1; solute carrier family 6, member 8", "tax_id": 10090, "disease": "cerebral creatine deficiency syndrome 1 (Disease Ontology:DOID:0050800); intellectual disability (Disease Ontology:DOID:1059); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (mmu:102857); (R-MMU-71288)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12439290;21183079;35822049;40021952;40885482", "class_list": "", "function": "Creatine:sodium symporter which mediates the uptake of creatine (PubMed:12439290). Plays an important role in supplying creatine to the brain via the blood-brain barrier (PubMed:12439290)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2ALM4;Q80YC9;Q8K4R3;Q8R1L0", "ec_number_list": [], "go_molecular_function": "GO:0005332 gamma-aminobutyric acid:sodium:chloride symporter activity;GO:0015220 choline transmembrane transporter activity;GO:0005309 creatine:sodium symporter activity;GO:0005308 creatine transmembrane transporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006865 amino acid transport;GO:0035725 sodium ion transmembrane transport;GO:0030163 protein catabolic process;GO:0015881 creatine transmembrane transport;GO:0006836 neurotransmitter transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8VBW1-2", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQS4-1", "uniprot_id": [ { "id": "S2546_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQS4", "type": "external" } ], "mass": 46224.0, "length": 418, "protein_name": "Mitochondrial outer membrane protein SLC25A46", "gene_name": "Slc25a46", "organism": "Mouse", "refseq_name": "mitochondrial outer membrane protein SLC25A46 isoform 1", "refseq_ac": [ { "id": "NP_080441", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080441", "type": "external" } ], "gene_names_uniprotkb": "Slc25a46", "gene_names_refseq": "1200007B05Rik; Slc25a46", "protein_names_uniprotkb": "Mitochondrial outer membrane protein SLC25A46; Solute carrier family 25 member 46", "protein_names_refseq": "mitochondrial outer membrane protein SLC25A46 isoform 1; mitochondrial outer membrane protein SLC25A46", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 6 (Disease Ontology:DOID:0080068); pontocerebellar hypoplasia type 1E (Disease Ontology:DOID:0112330); neuropathy (Disease Ontology:DOID:870)", "pathway": " (mmu:67453)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17242355;21183079;21750661;28376083;28376086;33300544;34428180;35820727", "class_list": "", "function": "Our mutant mice provide a valid model for understanding the mechanistic basis of the complex SLC25A46-mediated pathologies, as well as for screening potential therapeutic interventions. Publication Status: Online-Only, [RefSeq, PubMed]; Transmembrane protein of the mitochondrial outer membrane that controls mitochondrial organization. May regulate the assembly of the MICOS (mitochondrial contact site and cristae organizing system) complex which is essential to the biogenesis and dynamics of mitochondrial cristae, the inwards folds of the inner mitochondrial membrane. Through its interaction with the EMC (endoplasmic reticulum membrane protein complex), could regulate mitochondrial lipid homeostasis and thereby mitochondrial fission., [UniProtKB, UniProtKB]; We showed that the Slc25a46 disruption caused a fusion/fission imbalance and an abnormal mitochondrial architecture that disturbed mitochondrial metabolism. These data extended the range of phenotypes associated with Slc25a46 dysfunction. Moreover, this Slc25a46 knock-out mouse model should be useful to further elucidate the role of SLC25A46 in mitochondrial dynamics Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUD3;Q3UGG7;Q8VDX9", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0090149 mitochondrial membrane fission;GO:0048936 peripheral nervous system neuron axonogenesis;GO:0006839 mitochondrial transport;GO:0016358 dendrite development;GO:0007416 synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9CQS4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80UF4-1", "uniprot_id": [ { "id": "SDCG8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80UF4", "type": "external" } ], "mass": 82979.0, "length": 717, "protein_name": "Serologically defined colon cancer antigen 8 homolog", "gene_name": "Sdccag8", "organism": "Mouse", "refseq_name": "serologically defined colon cancer antigen 8 homolog isoform 1", "refseq_ac": [ { "id": "NP_084032", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084032", "type": "external" } ], "gene_names_uniprotkb": "Sdccag8; Cccap", "gene_names_refseq": "2700048G21Rik; 5730470G24Rik; Cccap; Sdccag8", "protein_names_uniprotkb": "Serologically defined colon cancer antigen 8 homolog; Centrosomal colon cancer autoantigen protein; mCCCAP", "protein_names_refseq": "centrosomal colon cancer autoantigen protein; serologically defined colon cancer antigen 8 homolog isoform 1; serologically defined colon cancer antigen 8 homolog", "tax_id": 10090, "disease": "Senior-Loken syndrome (Disease Ontology:DOID:0050576); Bardet-Biedl syndrome 16 (Disease Ontology:DOID:0110138); nephronophthisis (Disease Ontology:DOID:12712)", "pathway": " (mmu:76816); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 8, "publication_id_list": "12559564;20835237;21750661;24722439;25088364;27224062;29444170;35503560", "class_list": "", "function": "Ascribe the patterning defects in the limb and the secondary palate as well as lung abnormalities to loss of SDCCAG8, while the developmental defects in the brain are likely due to the loss of AKT3 Publication Status: Online-Only, [RefSeq, PubMed]; Characterization of two novel knock-in mouse models of syndromic retinal ciliopathy carrying hypomorphic Sdccag8 mutations., [RefSeq, PubMed]; Our analysis of Sdccag8(gt/gt) mice indicates that the pleiotropic phenotypes in these mice may arise through multiple tissue-specific disease mechanisms., [RefSeq, PubMed]; Plays a role in the establishment of cell polarity and epithelial lumen formation (PubMed:20835237). Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed:27224062)., [UniProtKB, PubMed, PubMed]; Results reveal a critical role for SDCCAG8 in controlling centrosomal properties and function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0097733 photoreceptor cell cilium;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0001764 neuron migration;GO:0030030 cell projection organization;GO:0007098 centrosome cycle;GO:0030010 establishment of cell polarity;GO:1902017 regulation of cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80UF4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K136-1", "uniprot_id": [ { "id": "SCNM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K136", "type": "external" } ], "mass": 25823.0, "length": 229, "protein_name": "Sodium channel modifier 1", "gene_name": "Scnm1", "organism": "Mouse", "refseq_name": "sodium channel modifier 1", "refseq_ac": [ { "id": "NP_001396781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001396781", "type": "external" } ], "gene_names_uniprotkb": "Scnm1; Scnm1-ps", "gene_names_refseq": "3110001I17Rik; Scnm1-ps; Scnm1", "protein_names_uniprotkb": "Sodium channel modifier 1", "protein_names_refseq": "sodium channel modifier 1, pseudogene; sodium channel modifier 1", "tax_id": 10090, "disease": "orofaciodigital syndrome XIX (Disease Ontology:DOID:0060960)", "pathway": " (mmu:69269)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12920299;13679025;17656373;19144319;21750661;28528544;32782141;32848054", "class_list": "", "function": "As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:12920299, PubMed:17656373). Plays a role in the regulation of primary cilia length and Hedgehog signaling (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Mutations in the voltage-gated sodium channel gene Scn8a lead to neurological problems in mice. For one particular mutation, Scn8amedJ, mice live to adulthood but have tremors and muscle weakness, among other problems, in all strains except those derived from C57BL6 mice. In these strains, the product of the Scnm1 gene (229 aa) partially overcomes the effects of the Scn8amedJ mutation. However, in C57BL6-derived mice, a one nt change in the penultimate exon creates a premature stop codon, truncating the Scnm1 protein at 186 aa. This truncated protein lacks the ability to overcome the effects of the Scn8amedJ mutation, and these mice suffer paralysis and juvenile death. [provided by RefSeq, Jul 2009]., [RefSeq]; Scnm1 is the first example of a modifier gene which influences disease severity through a trans-effect on splicing of the disease gene transcript., [RefSeq, PubMed]; Variation between inbred strains of mice can be used to identify modifier genes affecting the susceptibility to inherited disease. The severity of the neurological disorder is determined by the modifier locus Scnm1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CXV5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0005689 U12-type spliceosomal complex;GO:0071016 U12-type precatalytic spliceosome", "go_biological_process": "GO:0008380 RNA splicing;GO:0000380 alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8K136-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920H1-2", "uniprot_id": [ { "id": "SG3A2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q920H1", "type": "external" } ], "mass": 9819.0, "length": 91, "protein_name": "Secretoglobin family 3A member 2", "gene_name": "Scgb3a2", "organism": "Mouse", "refseq_name": "secretoglobin family 3A member 2 isoform 1", "refseq_ac": [ { "id": "NP_001276572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276572", "type": "external" } ], "gene_names_uniprotkb": "Scgb3a2; Pnsp1; Ugrp1", "gene_names_refseq": "LuLeu1; Pnsp1; Scgb3a2; UGRP1; Utgrp1", "protein_names_uniprotkb": "Secretoglobin family 3A member 2; PnSP-1; Pneumo secretory protein 1; Uteroglobin-related protein 1", "protein_names_refseq": "pneumo secretory protein 1; secretoglobin family 3A member 2 isoform 1; uteroglobin related protein 1", "tax_id": 10090, "disease": "sinusitis (Disease Ontology:DOID:0050127); asthma (Disease Ontology:DOID:2841); lung non-small cell carcinoma (Disease Ontology:DOID:3908); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483)", "pathway": " (mmu:117158)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11682631;12175512;12406855;12915772;16456148;18535256;24213919;24514953;25242865;26559674", "class_list": "", "function": "Highest HIN-1 and UGRP-1 expression is detected in the lung, while lower level HIN-1 expression is also detected in the stomach, heart, small intestine, uterine and mammary glands, [RefSeq, PubMed]; Secreted cytokine-like protein (By similarity). Binds to the scavenger receptor MARCO (By similarity). Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast (By similarity). Strongly inhibits phospholipase A2 (PLA2G1B) activity (PubMed:24213919). Seems to have anti-inflammatory effects in respiratory epithelium (PubMed:16456148, PubMed:25242865). Also has anti-fibrotic activity in lung (PubMed:24213919, PubMed:26559674). May play a role in fetal lung development and maturation (PubMed:18535256). Promotes branching morphogenesis during early stages of lung development (PubMed:18535256). In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) (PubMed:24514953)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; UGRP1 does not play a major role in the development of bronchial asthma in our Caucasian population., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5D060;Q920H2;Q920H3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q920H1-2", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SS91-1", "uniprot_id": [ { "id": "SUN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SS91", "type": "external" } ], "mass": 36758.0, "length": 320, "protein_name": "SUN domain-containing protein 3", "gene_name": "Sun3", "organism": "Mouse", "refseq_name": "SUN domain-containing protein 3 isoform a", "refseq_ac": [ { "id": "NP_001277448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277448", "type": "external" } ], "gene_names_uniprotkb": "Sun3; Sunc1", "gene_names_refseq": "Sun3; Sunc1", "protein_names_uniprotkb": "SUN domain-containing protein 3; Sad1/unc-84 domain-containing protein 1", "protein_names_refseq": "SUN domain-containing protein 3 isoform a; SUN domain-containing protein 3; Sad1 and UNC84 domain containing 1; sad1/unc-84 domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:194974)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20711465;26621829;32156700", "class_list": "", "function": "As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenesis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette., [UniProtKB, PubMed]; The testis-specific LINC component SUN3 is essential for sperm head shaping during mouse spermiogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHY0", "ec_number_list": [], "go_molecular_function": "GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005637 nuclear inner membrane;GO:0034993 meiotic nuclear membrane microtubule tethering complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5SS91-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R3N6-1", "uniprot_id": [ { "id": "THOC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R3N6", "type": "external" } ], "mass": 75436.0, "length": 657, "protein_name": "THO complex subunit 1", "gene_name": "Thoc1", "organism": "Mouse", "refseq_name": "THO complex subunit 1 isoform 1", "refseq_ac": [ { "id": "NP_705780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705780", "type": "external" } ], "gene_names_uniprotkb": "Thoc1; Hpr1", "gene_names_refseq": "3110002N20Rik; NMP-84; Thoc1; tho1", "protein_names_uniprotkb": "THO complex subunit 1; Nuclear matrix protein p84", "protein_names_refseq": "THO complex subunit 1 isoform 1; THO complex subunit 1; nuclear matrix protein p84", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 86 (Disease Ontology:DOID:0070610)", "pathway": " (mmu:225160); (R-MMU-159236); (R-MMU-72187)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;16705185;16909111;17242355;19307311;21183079;21750661;25428506;27001308;30084848;31219806;32776944;34428180", "class_list": "", "function": "Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (By similarity). Required for efficient export of polyadenylated RNA (By similarity). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B (By similarity). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (By similarity). Regulates transcriptional elongation of a subset of genes (By similarity). Involved in genome stability by preventing co-transcriptional R-loop formation (By similarity). May play a role in hair cell formation, hence may be involved in hearing (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1 (By similarity). Essential for early embryonic development. Required for normal gene expression during postnatal testis development., [UniProtKB, PubMed, PubMed]; Results found that Thoc1 deficiency delays embryo death, and suggest that Thoc1 is required to support increased expression of E2f and apoptotic regulatory genes that trigger apoptosis upon Rb1 loss. Publication Status: Online-Only, [RefSeq, PubMed]; The generation and phenotypic characterization of mice containing a null allele of the Thoc1 gene is described., [RefSeq, PubMed]; These findings support the notion that Thoc1-mediated RNP assembly contributes to the coordinated expression of genes necessary for normal differentiation and development in vivo., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWD5;Q8BXY3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0000347 THO complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0007165 signal transduction;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8R3N6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHL3-1", "uniprot_id": [ { "id": "TB10B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHL3", "type": "external" } ], "mass": 87275.0, "length": 798, "protein_name": "TBC1 domain family member 10B", "gene_name": "Tbc1d10b", "organism": "Mouse", "refseq_name": "TBC1 domain family member 10B", "refseq_ac": [ { "id": "NP_653105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653105", "type": "external" } ], "gene_names_uniprotkb": "Tbc1d10b", "gene_names_refseq": "1110003P22Rik; Tbc1d10b", "protein_names_uniprotkb": "TBC1 domain family member 10B; Protein wz3-85", "protein_names_refseq": "TBC1 domain family member 10B; protein wz3-85", "tax_id": 10090, "disease": "", "pathway": " (mmu:68449); (R-MMU-8854214)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "17114649;19144319;21183079;21750661;22517741;22645316;23671284;24129315;26495903;30059200;31219806;34678516;35822049;36852467;39084876;40021952;40885482", "class_list": "", "function": "Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A and RAB35. Does not act on RAB2A and RAB6A., [UniProtKB, UniProtKB]; EPI64B can serve as a potential physiological GAP for Rab27B and thereby participate in the regulation of exocytosis in pancreatic acinar cells., [RefSeq, PubMed]; Rit1-TBC1D10B signaling modulates FcgammaR-mediated phagosome formation in RAW264 macrophages. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q6GQW9;Q6PIZ5;Q91XR3", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0043087 regulation of GTPase activity;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q8BHL3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YYM4-1", "uniprot_id": [ { "id": "WDR72_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YYM4", "type": "external" } ], "mass": 124410.0, "length": 1114, "protein_name": "WD repeat-containing protein 72", "gene_name": "Wdr72", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 72 isoform 1", "refseq_ac": [ { "id": "NP_001028672", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028672", "type": "external" } ], "gene_names_uniprotkb": "Wdr72", "gene_names_refseq": "D230040E23; Wdr72", "protein_names_uniprotkb": "WD repeat-containing protein 72", "protein_names_refseq": "WD repeat-containing protein 72 isoform 1; WD repeat-containing protein 72", "tax_id": 10090, "disease": "amelogenesis imperfecta hypomaturation type 2A3 (Disease Ontology:DOID:0110061)", "pathway": " (mmu:546144)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19853237;21183079;21750661;25008349;26247047;31336344;35301423", "class_list": "", "function": "Identification of the C-terminal region in Amelogenesis Imperfecta causative protein WDR72 required for Golgi localization. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a major role in formation of tooth enamel (PubMed:25008349, PubMed:26247047). Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins (PubMed:25008349, PubMed:26247047). May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane (PubMed:26247047)., [UniProtKB, PubMed, PubMed]; TGF-beta1 affects enamel mineralization by modulating RUNX2 and thus affecting the expression of Wdr72., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0006897 endocytosis;GO:0016485 protein processing;GO:0022617 extracellular matrix disassembly;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "D3YYM4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20239-1", "uniprot_id": [ { "id": "ZP2_MOUSE", "url": "https://www.uniprot.org/uniprot/P20239", "type": "external" } ], "mass": 80210.0, "length": 713, "protein_name": "Zona pellucida sperm-binding protein 2", "gene_name": "Zp2", "organism": "Mouse", "refseq_name": "zona pellucida sperm-binding protein 2 isoform 1 preproprotein", "refseq_ac": [ { "id": "NP_035905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035905", "type": "external" } ], "gene_names_uniprotkb": "Zp2; Zp-2; Zpa", "gene_names_refseq": "Zp-2; Zp2", "protein_names_uniprotkb": "Zona pellucida sperm-binding protein 2; Zona pellucida glycoprotein 2; Zona pellucida protein A; Zp-2", "protein_names_refseq": "zona pellucida glycoprotein ZP2; zona pellucida protein A; zona pellucida sperm-binding protein 2 isoform 1 preproprotein; zona pellucida sperm-binding protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:22787); (R-MMU-2534343)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10713085;12799386;14673092;1690843;17559063;21750661;22472438;26811476;28622512;30084848;3845123", "class_list": "", "function": "Characterization of native mouse zona pellucida proteins by mass spectrometry, [RefSeq, PubMed]; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor., [UniProtKB, PubMed]; This gene encodes a member of the zona pellucida family of glycoproteins that play an important role in the survival of growing oocytes, successful fertilization and the passage of early embryos through the oviduct. The encoded preproprotein undergoes proteolytic processing to generate the mature polypeptide that is incorporated into the extracellular matrix surrounding mouse oocytes. Mice lacking the encoded protein develop defective zonae pellucidae that disrupt folliculogenesis, fertility and development. [provided by RefSeq, Sep 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 5, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 71, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035804 structural constituent of egg coat;GO:0032190 acrosin binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0005771 multivesicular body;GO:0035805 egg coat", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0060468 prevention of polyspermy", "synthesized_glycan_count": 0, "hit_score": 9.1, "record_id": "P20239-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1100000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61967-1", "uniprot_id": [ { "id": "ZFP90_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61967", "type": "external" } ], "mass": 72423.0, "length": 636, "protein_name": "Zinc finger protein 90", "gene_name": "Zfp90", "organism": "Mouse", "refseq_name": "zinc finger protein 90 isoform 2", "refseq_ac": [ { "id": "NP_035894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035894", "type": "external" } ], "gene_names_uniprotkb": "Zfp90; Nk10", "gene_names_refseq": "6430515L01Rik; KRAB17; NK10; Zfp64; Zfp83; Zfp90; mKIAA1954", "protein_names_uniprotkb": "Zinc finger protein 90; Zfp-90; Zinc finger protein NK10", "protein_names_refseq": "Nk10 expressed protein; zfp-90; zinc finger protein 83; zinc finger protein 90 homolog; zinc finger protein 90 isoform 2; zinc finger protein NK10", "tax_id": 10090, "disease": "", "pathway": " (mmu:22751); (R-MMU-212436)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21284946;21750661;29880802;34428180;7576184", "class_list": "", "function": "Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes., [UniProtKB, PubMed, PubMed]; Zfp90 was highly expressed in hematopoietic stem cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4J5;Q543I6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q61967-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CU65-1", "uniprot_id": [ { "id": "ZMYM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CU65", "type": "external" } ], "mass": 154642.0, "length": 1376, "protein_name": "Zinc finger MYM-type protein 2", "gene_name": "Zmym2", "organism": "Mouse", "refseq_name": "zinc finger MYM-type protein 2 isoform 1", "refseq_ac": [ { "id": "NP_083774", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083774", "type": "external" } ], "gene_names_uniprotkb": "Zmym2; Zfp198; Znf198", "gene_names_refseq": "5830413P05Rik; FIM; MYM; RAMP; SCLL; Zfp198; Zmym2; Znf198", "protein_names_uniprotkb": "Zinc finger MYM-type protein 2; Zinc finger protein 198", "protein_names_refseq": "zinc finger MYM-type protein 2 isoform 1; zinc finger MYM-type protein 2; zinc finger protein 198", "tax_id": 10090, "disease": "", "pathway": " (mmu:76007); (R-MMU-9764725)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "17242355;20173027;21183079;21527531;21750661;22872234;25428506;30084848;30779550;32891193;34203471;34428180;37395395", "class_list": "", "function": "Involved in the negative regulation of transcription., [UniProtKB, UniProtKB]; The study demonstrates frequent, constitutive activation of Notch1 and its downstream target genes in T-cell lymphomas that arose in a murine model of Zmym2-Fgfr1 stem cell leukemia-lymphoma syndrome., [RefSeq, PubMed]; This gene encodes a protein that contains nine MYM-type zinc finger motifs. Expression of this gene may mediate the inhibition of hematopoietic cell development during ontogeny, and the encoded protein may also play a role in transforming growth factor-beta signaling as a Smad binding protein. [provided by RefSeq, Feb 2011]., [RefSeq]; ZMYM2 is essential for methylation of germline genes and active transposons in embryonic development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RUS2;Q3UUZ8;Q3UXK7;Q80XP0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016605 PML body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9CU65-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDM1-1", "uniprot_id": [ { "id": "ZGPAT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDM1", "type": "external" } ], "mass": 56411.0, "length": 511, "protein_name": "Zinc finger CCCH-type with G patch domain-containing protein", "gene_name": "Zgpat", "organism": "Mouse", "refseq_name": "zinc finger CCCH-type with G patch domain-containing protein", "refseq_ac": [ { "id": "NP_001041613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041613", "type": "external" } ], "gene_names_uniprotkb": "Zgpat; Kiaa1847", "gene_names_refseq": "1500006I01Rik; Zgpat", "protein_names_uniprotkb": "Zinc finger CCCH-type with G patch domain-containing protein", "protein_names_refseq": "zinc finger CCCH-type with G patch domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:229007)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AU20;A2AU21;Q3TW85;Q69Z90;Q8BWW2", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0007175 negative regulation of epidermal growth factor-activated receptor activity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VDM1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UPF5-4", "uniprot_id": [ { "id": "ZCCHV_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UPF5", "type": "external" } ], "mass": 112533.0, "length": 996, "protein_name": "Zinc finger CCCH-type antiviral protein 1", "gene_name": "Zc3hav1", "organism": "Mouse", "refseq_name": "zinc finger CCCH-type antiviral protein 1 isoform 3", "refseq_ac": [ { "id": "NP_001334051", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334051", "type": "external" } ], "gene_names_uniprotkb": "Zc3hav1", "gene_names_refseq": "1200014N16Rik; 2900058M19Rik; 9130009D18Rik; 9830115L13Rik; ARTD13; D6Bwg1452e; PARP-13; PARP13; ZAP; Zc3hav1", "protein_names_uniprotkb": "Zinc finger CCCH-type antiviral protein 1; ADP-ribosyltransferase diphtheria toxin-like 13; ARTD13; Inactive Poly [ADP-ribose] polymerase 13; PARP-13", "protein_names_refseq": "ADP-ribosyltransferase diphtheria toxin-like 13; inactive Poly [ADP-ribose] polymerase 13; zinc finger CCCH-type antiviral protein 1 isoform 3; zinc finger CCCH-type antiviral protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:78781)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "17242355;17947660;19131326;19144319;21102435;21183079;22951821;23776219;25428506;30084848;30779550;31219806;31599954;31914396;32782141;34428180;35820727;37828378;39478149;40997131", "class_list": "", "function": "Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae, such as murine leukemia virus (MoMLV), filoviridae and togaviridae., [UniProtKB, UniProtKB]; Exhibits stronger antiviral activity than isoform 3 against Sindbis virus (SINV) infection. Increased antiviral activity may be due to more efficient targeting to endocytic membranes through S-farnesylation., [UniProtKB, PubMed]; Molecular Mechanism of RNA Recognition by Zinc-Finger Antiviral Protein., [RefSeq, PubMed]; Positive regulator of RIGI signaling during the innate antiviral immune response. Associates with RIGI to promote its oligomerization and ATPase activity stimulation, leading to robust activation of IRF3 and NF-kappa-B transcription factors and eventually to the expression of type I IFNs and IFN stimulated genes (ISGs)., [UniProtKB, PubMed]; ZAP inhibits M2 expression and regulates the maintenance of MHV-68 latency, [RefSeq, PubMed]; ZC3HAV1 facilitates STING activation and enhances inflammation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3Z5I1;G3X9X5;Q8K302;Q9CTU4;Q9DBS7", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0017151 DEAD/H-box RNA helicase binding;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0032727 positive regulation of interferon-alpha production;GO:0050691 regulation of defense response to virus by host;GO:0045087 innate immune response;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q3UPF5-4", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDZ4-1", "uniprot_id": [ { "id": "ZDHC5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDZ4", "type": "external" } ], "mass": 77501.0, "length": 715, "protein_name": "Palmitoyltransferase ZDHHC5", "gene_name": "Zdhhc5", "organism": "Mouse", "refseq_name": "palmitoyltransferase ZDHHC5", "refseq_ac": [ { "id": "NP_659136", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659136", "type": "external" } ], "gene_names_uniprotkb": "Zdhhc5; Kiaa1748", "gene_names_refseq": "1110032A17Rik; Zdhhc5; Zisp", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC5; 2.3.1.225; DHHC-5; Zinc finger DHHC domain-containing protein 5", "protein_names_refseq": "DHHC-5; palmitoyltransferase ZDHHC5; probable palmitoyltransferase ZDHHC5; zinc finger DHHC domain-containing protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:228136)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "16075062;17242355;18034455;19144319;20178993;21183079;21820437;22081607;22645316;24129315;24562000;25428506;30605677;31219806;34428180;34724258;38530158;41182177", "class_list": "", "function": "Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:22081607, PubMed:38530158). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:24562000). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (By similarity). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (By similarity). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (By similarity). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (By similarity). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:30605677). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:30605677). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (PubMed:34724258). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (By similarity). Palmitoylates NLRP3 to promote inflammasome assembly and activation (By similarity). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158). Palmitoylates IFT81 and may contribute to maintaining its protein stability during spermatogenesis thereby supporting proper sperm tail assembly (PubMed:41182177)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q2TGE8;Q69ZB5;Q8R2X7", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0044546 NLRP3 inflammasome complex assembly;GO:0007283 spermatogenesis;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8VDZ4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NS65-1", "uniprot_id": [ { "id": "GPR17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NS65", "type": "external" } ], "mass": 37839.0, "length": 339, "protein_name": "Uracil nucleotide/cysteinyl leukotriene receptor", "gene_name": "Gpr17", "organism": "Mouse", "refseq_name": "uracil nucleotide/cysteinyl leukotriene receptor", "refseq_ac": [ { "id": "NP_001020552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020552", "type": "external" } ], "gene_names_uniprotkb": "Gpr17", "gene_names_refseq": "Gpr17", "protein_names_uniprotkb": "Uracil nucleotide/cysteinyl leukotriene receptor; G protein-coupled receptor 17; UDP/CysLT receptor", "protein_names_refseq": "UDP/CysLT receptor; uracil nucleotide/cysteinyl leukotriene receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:574402); (R-MMU-391906); (R-MMU-416476); (R-MMU-417957); (R-MMU-418594)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "12679517;18974869;19561298;19838178;20574000;36815579;37783234;37990234", "class_list": "", "function": "Analysis of the GPR17 receptor in NG2-glia under physiological conditions unravels a new subset of oligodendrocyte progenitor cells with distinct functions., [RefSeq, PubMed]; Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia (By similarity)., [UniProtKB]; G protein-coupled receptor 17 is regulated by WNT pathway during oligodendrocyte precursor cell differentiation., [RefSeq, PubMed]; GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4., [RefSeq, PubMed]; GPR17 may act as a 'sensor' that is activated upon brain injury on several embryonically distinct cell types, and may play a key role in both inducing neuronal death inside the ischemic core and in orchestrating the local remodeling/repair response., [RefSeq, PubMed]; GPR17 negatively regulates type 1 cysteinyl leukotriene receptor (CysLT1R)-mediated inflammatory cell accumulation in the bronchoalveolar lavage fluid and lung, in both the antigen presentation and downstream phases of allergic pulmonary inflammation. Erratum:[J Immunol. 2010 Oct 1;185(7):4506], [RefSeq, PubMed]; GPR17 orchestrates the transition between immature and myelinating oligodendrocytes via an ID protein-mediated negative regulation and may serve as a potential therapeutic target for CNS myelin repair., [RefSeq, PubMed]; Knockdown and inhibition of hippocampal GPR17 attenuates lipopolysaccharide-induced cognitive impairment in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80UD2", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033612 receptor serine/threonine kinase binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0002862 negative regulation of inflammatory response to antigenic stimulus;GO:0048709 oligodendrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6NS65-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R002-1", "uniprot_id": [ { "id": "IFI2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R002", "type": "external" } ], "mass": 50466.0, "length": 445, "protein_name": "Interferon-activable protein 202", "gene_name": "Ifi202", "organism": "Mouse", "refseq_name": "interferon-activable protein 202", "refseq_ac": [ { "id": "NP_032353", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032353", "type": "external" } ], "gene_names_uniprotkb": "Ifi202; Ifi202a; Ifi202b", "gene_names_refseq": "Ifbip-1; Ifi202a; Ifi202b; Ifi202c; Ifi202; p202", "protein_names_uniprotkb": "Interferon-activable protein 202; Ifi-202; Interferon-inducible protein p202; Lupus susceptibility protein p202", "protein_names_refseq": "Interferon-activatable protein 202a (Ifi-202a) (Interferon-inducible protein p202a); ifi-202; interferon activated gene 202A; interferon-activable protein 202; interferon-inducible protein p202; lupus susceptibility protein p202", "tax_id": 10090, "disease": "", "pathway": " (mmu:26388)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10493828;11567633;14764608;16670293;19131592;22299025;23567559;23850291;24419611;2477366;29853536;30104205;30246031;31219806;36210013;37062941;8454910;8524315;8910340;9821952", "class_list": "", "function": "DNA-binding protein involved in innate immune response and has anti-inflammatory activity (PubMed:19131592, PubMed:23567559, PubMed:23850291). Inhibits caspase activation in response to cytosolic DNA by preventing activation of the AIM2 inflammasome, probably by sequestering cytoplasmic DNA and preventing its being bound by AIM2 (PubMed:19131592, PubMed:23567559, PubMed:23850291). Also inhibits activation of the AIM2 inflammasome via a direct interaction with AIM2, which prevents the interaction between AIM2 and PYCARD and formation of the AIM2 inflammasome (PubMed:23850291). Binds double-stranded DNA (dsDNA) in the cytosol (PubMed:19131592, PubMed:23567559, PubMed:23850291, PubMed:24419611). Has anti-apoptotic effects due to inhibition of the transcriptional activity of TP53/p53 (PubMed:16670293). Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin (PubMed:8524315)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Enforced expression of IFI16-b inhibits the activation of AIM2 inflammasome, whereas knockdown of IFI16-b augments interleukin-1b secretion triggered by dsDNA but not dsRNA Thus, cytoplasm-localized IFI16-b is functionally equivalent to mouse p202 that exerts an inhibitory effect on AIM2 inflammasome. ., [RefSeq, PubMed]; IFI16/Ifi202 released from breast cancer induces secretion of inflammatory cytokines from macrophages and promotes tumor growth., [RefSeq, PubMed]; P202 promotes osteogenesis in mouse bone marrow stromal cells. Publication Status: Online-Only, [RefSeq, PubMed]; The expression level of Ifi202b showed the most sex difference in correlation with known immune-related genes Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 37, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QLD9;P15091;Q38JF1;Q7TMN6;Q8VEL7", "ec_number_list": [], "go_molecular_function": "GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0051260 protein homooligomerization;GO:0051289 protein homotetramerization;GO:0002218 activation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9R002-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z123-1", "uniprot_id": [ { "id": "SEM4F_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z123", "type": "external" } ], "mass": 84490.0, "length": 777, "protein_name": "Semaphorin-4F", "gene_name": "Sema4f", "organism": "Mouse", "refseq_name": "semaphorin-4F isoform a precursor", "refseq_ac": [ { "id": "NP_035480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035480", "type": "external" } ], "gene_names_uniprotkb": "Sema4f; Semaw", "gene_names_refseq": "Sema W; Sema4f", "protein_names_uniprotkb": "Semaphorin-4F; Sema W; Semaphorin-W", "protein_names_refseq": "semaphorin-4F isoform a precursor; semaphorin-4F; semaphorin-W", "tax_id": 10090, "disease": "", "pathway": " (mmu:20355); (R-MMU-9696264)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10051670;11483650;21183079;21750661;21945643;30899004;35820727", "class_list": "", "function": "Probable cell surface receptor that regulates oligodendroglial precursor cell migration (PubMed:21945643). Might also regulate differentiation of oligodendroglial precursor cells (By similarity). Has growth cone collapse activity against retinal ganglion-cell axons (By similarity)., [UniProtKB, PubMed, UniProtKB]; This gene encodes a member of semaphorin family of membrane-bound and secreted proteins that are involved in guiding axonal growth. The encoded protein is a transmembrane protein localized to the glutamatergic synapses via its association with a synapse-associated scaffolding protein. In oligodendrocyte precursor cells, the encoded protein contributes to the outward migration and differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q505G0;Q9R1Y1", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0050919 negative chemotaxis;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9Z123-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SSN7-1", "uniprot_id": [ { "id": "SFT2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SSN7", "type": "external" } ], "mass": 17923.0, "length": 159, "protein_name": "Vesicle transport protein SFT2A", "gene_name": "Sft2d1", "organism": "Mouse", "refseq_name": "vesicle transport protein SFT2A isoform 1", "refseq_ac": [ { "id": "NP_598875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598875", "type": "external" } ], "gene_names_uniprotkb": "Sft2d1", "gene_names_refseq": "5630401J11Rik; Sft2d1", "protein_names_uniprotkb": "Vesicle transport protein SFT2A; SFT2 domain-containing protein 1", "protein_names_refseq": "SFT2 domain-containing protein 1; vesicle transport protein SFT2A isoform 1; vesicle transport protein SFT2A", "tax_id": 10090, "disease": "", "pathway": " (mmu:106489)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18250455;19144319;21750661;25605945;34428180", "class_list": "", "function": "May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L3Q4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0015031 protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5SSN7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q93092-1", "uniprot_id": [ { "id": "TALDO_MOUSE", "url": "https://www.uniprot.org/uniprot/Q93092", "type": "external" } ], "mass": 37387.0, "length": 337, "protein_name": "Transaldolase", "gene_name": "Taldo1", "organism": "Mouse", "refseq_name": "transaldolase", "refseq_ac": [ { "id": "NP_035658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035658", "type": "external" } ], "gene_names_uniprotkb": "Taldo1; Taldo; Tal", "gene_names_refseq": "Taldo1", "protein_names_uniprotkb": "Transaldolase; 2.2.1.2", "protein_names_refseq": "transaldolase", "tax_id": 10090, "disease": "carbohydrate metabolic disorder (Disease Ontology:DOID:2978)", "pathway": " (mmu:21351); (R-MMU-163754); (R-MMU-71336)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "17003133;19436114;21183079;21750661;23806337;27703206;34428180;36288343;37507081;37528662;39927985;9524206", "class_list": "", "function": "Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Reduced beta-catenin phosphorylation and enhanced c-Jun expression in Taldo1-/- livers reflected adaptation to oxidative stress, [RefSeq, PubMed]; These data reveal an essential role of transaldolase in sperm-cell mitochondrial function and, thus, male fertility., [RefSeq, PubMed]; These results demonstrate that the nucleocytoplasmic distribution of TALDO1, modulated via alternative translational initiation and dimer formation, plays an important role in a wide range of metabolic networks Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a key enzyme of the nonoxidative pentose phosphate pathway that provides ribose-5-phosphate for nucleic acid synthesis and nicotinamide adenine dinucleotide phosphate (NADPH) for lipid biosynthesis. The encoded protein is important for maintaining structure and function of mitochondria. Studies in knockout mice identify that deficiency of this gene product is a cause of sperm dysmotility and male infertility. Deficiency of this protein has also been identified as a cause of hepatocarcinogenesis in mice. Two related pseudogenes have been identified on chromosome 10. [provided by RefSeq, Mar 2010]., [RefSeq]; Transaldolase inhibits CD36 expression by modulating glutathione-p38 signaling, exerting protective effects against macrophage foam cell formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70358;P70703;Q52KM4", "ec_number_list": [ { "id": "2.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0030246 carbohydrate binding;GO:0004801 transaldolase activity;GO:0048029 monosaccharide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0019682 glyceraldehyde-3-phosphate metabolic process;GO:0009052 pentose-phosphate shunt, non-oxidative branch;GO:0005975 carbohydrate metabolic process;GO:0006098 pentose-phosphate shunt;GO:0006002 fructose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q93092-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0N3-1", "uniprot_id": [ { "id": "SYT11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0N3", "type": "external" } ], "mass": 48333.0, "length": 430, "protein_name": "Synaptotagmin-11", "gene_name": "Syt11", "organism": "Mouse", "refseq_name": "synaptotagmin-11", "refseq_ac": [ { "id": "NP_061274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061274", "type": "external" } ], "gene_names_uniprotkb": "Syt11", "gene_names_refseq": "1500004A13Rik; 3632445O20Rik; 5430404N14Rik; 6530420C11Rik; Syt11", "protein_names_uniprotkb": "Synaptotagmin-11; Synaptotagmin XI; SytXI", "protein_names_refseq": "synaptotagmin-11; sytXI", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:229521); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10531343;18322192;21183079;21750661;23303671;24882364;26450452;27278822;28686317;29311685;30808661;31219806;32976921;34428180;36210013;36787382;37474308;37924268;38698221", "class_list": "", "function": "Palmitoylation of the Parkinson's disease-associated protein synaptotagmin-11 links its turnover to alpha-synuclein homeostasis., [RefSeq, PubMed]; Parkin-dependent and -independent degradation of synaptotagmin-11 in neurons and astrocytes., [RefSeq, PubMed]; Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+) (Probable). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval (PubMed:29311685). Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process (PubMed:29311685). Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity (PubMed:30808661). In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis (PubMed:23303671, PubMed:28686317). In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane (PubMed:26450452). Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway (PubMed:27278822)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Synaptotagmin-11 Inhibits Synaptic Vesicle Endocytosis via Endophilin A1., [RefSeq, PubMed]; Synaptotagmin-11 facilitates assembly of a presynaptic signaling complex in post-Golgi cargo vesicles., [RefSeq, PubMed]; Synaptotagmin-11 regulates immune functions of microglia in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQG8", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0005544 calcium-dependent phospholipid binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0001891 phagocytic cup;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0001778 plasma membrane repair;GO:1903979 negative regulation of microglial cell activation;GO:0045806 negative regulation of endocytosis;GO:0007612 learning;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9R0N3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZP2-1", "uniprot_id": [ { "id": "SYN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZP2", "type": "external" } ], "mass": 63315.0, "length": 579, "protein_name": "Synapsin-3", "gene_name": "Syn3", "organism": "Mouse", "refseq_name": "synapsin-3 isoform 1", "refseq_ac": [ { "id": "NP_038750", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038750", "type": "external" } ], "gene_names_uniprotkb": "Syn3", "gene_names_refseq": "Syn3", "protein_names_uniprotkb": "Synapsin-3; Synapsin III", "protein_names_refseq": "synapsin IIIa; synapsin-3 isoform 1; synapsin-3", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:27204); (R-MMU-181429); (R-MMU-212676)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11471062;16452087;17114649;20173027;21183079;21750661;25428506;37907739", "class_list": "", "function": "May be involved in the regulation of neurotransmitter release and synaptogenesis. Binds ATP with high affinity and ADP with a lower affinity. This is consistent with a catalytic role of the C-domain in which ADP would be dissociated by cellular ATP after bound ATP was hydrolyzed (By similarity)., [UniProtKB]; PLCgamma1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QNQ6", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0014069 postsynaptic density;GO:0045202 synapse;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0097091 synaptic vesicle clustering;GO:0099504 synaptic vesicle cycle;GO:0050808 synapse organization;GO:0007269 neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8JZP2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58802-1", "uniprot_id": [ { "id": "TB10A_MOUSE", "url": "https://www.uniprot.org/uniprot/P58802", "type": "external" } ], "mass": 56202.0, "length": 500, "protein_name": "TBC1 domain family member 10A", "gene_name": "Tbc1d10a", "organism": "Mouse", "refseq_name": "TBC1 domain family member 10A", "refseq_ac": [ { "id": "NP_598784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598784", "type": "external" } ], "gene_names_uniprotkb": "Tbc1d10a; Epi64; Tbc1d10", "gene_names_refseq": "EPI64; Tbc1d10a; Tbc1d10; mFLJ00288", "protein_names_uniprotkb": "TBC1 domain family member 10A; EBP50-PDX interactor of 64 kDa; EPI64 protein", "protein_names_refseq": "EBP50-PDX interactor of 64 kDa; TBC1 domain family member 10A", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); Ewing sarcoma (Disease Ontology:DOID:3369)", "pathway": " (mmu:103724); (R-MMU-8854214)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11285285;16923811;21183079;21750661;22645316;25428506;34428180;40885482", "class_list": "", "function": "EPI64 is a GTPase-activating protein specific for Rab27A, [RefSeq, PubMed]; GTPase-activating protein (GAP) specific for RAB27A and RAB35. Does not show GAP activity for RAB2A, RAB3A and RAB4A., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005902 microvillus", "go_biological_process": "GO:0042147 retrograde transport, endosome to Golgi;GO:0045862 positive regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P58802-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXJ1-1", "uniprot_id": [ { "id": "SYEM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXJ1", "type": "external" } ], "mass": 58326.0, "length": 523, "protein_name": "Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial", "gene_name": "Ears2", "organism": "Mouse", "refseq_name": "nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_080416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080416", "type": "external" } ], "gene_names_uniprotkb": "Ears2; Kiaa1970", "gene_names_refseq": "3230401I01Rik; Ears2; mKIAA1970; mtGluRS", "protein_names_uniprotkb": "Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial; 6.1.1.17; 6.1.1.24; GluRS; Glutamate--tRNA(Gln) ligase EARS2, mitochondrial; Glutamyl-tRNA synthetase; Mitochondrial glutamyl-tRNA synthetase; mtGluRS", "protein_names_refseq": "gluRS; glutamate--tRNA ligase; glutamate--tRNA(Gln) ligase EARS2, mitochondrial; glutamyl-tRNA synthetase 2 (mitochondrial)(putative); mitochondrial glutamyl-tRNA synthetase; nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial precursor; nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial; probable glutamate--tRNA ligase, mitochondrial; probable glutamyl-tRNA synthetase, mitochondrial", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 12 (Disease Ontology:DOID:0111493)", "pathway": " (mmu:67417)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23806337;25428506;30084848", "class_list": "", "function": "Non-discriminating glutamyl-tRNA synthetase that catalyzes aminoacylation of both mitochondrial tRNA(Glu) and tRNA(Gln) and participates in RNA aminoacylation for mitochondrial protein translation. Attachs glutamate to tRNA(Glu) or tRNA(Gln) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) or tRNA(Gln). In vitro, cytoplasmic tRNA(Gln) is slightly glutamylated, but with low activity., [UniProtKB, UniProtKB]; This gene encodes a putative member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in a similar gene in human have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12). [provided by RefSeq, Mar 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJB3", "ec_number_list": [ { "id": "6.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.15", "type": "external" }, { "id": "6.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.17", "type": "external" }, { "id": "6.1.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.24", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0000049 tRNA binding;GO:0004818 glutamate-tRNA ligase activity;GO:0050561 glutamate-tRNA(Gln) ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006424 glutamyl-tRNA aminoacylation;GO:0070127 tRNA aminoacylation for mitochondrial protein translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CXJ1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZ16-1", "uniprot_id": [ { "id": "T178A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZ16", "type": "external" } ], "mass": 33082.0, "length": 297, "protein_name": "Transmembrane protein 178A", "gene_name": "Tmem178a", "organism": "Mouse", "refseq_name": "transmembrane protein 178A precursor", "refseq_ac": [ { "id": "NP_080792", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080792", "type": "external" } ], "gene_names_uniprotkb": "Tmem178a; Tmem178", "gene_names_refseq": "2810417M05Rik; Tmem178a; Tmem178", "protein_names_uniprotkb": "Transmembrane protein 178A", "protein_names_refseq": "transmembrane protein 178A precursor; transmembrane protein 178A", "tax_id": 10090, "disease": "", "pathway": " (mmu:68027)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;26644563;30879886;37534578", "class_list": "", "function": "Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1 (PubMed:26644563)., [UniProtKB, PubMed]; Data identify a novel Plcgamma2/Tmem178 axis as a modulator of inflammatory cytokine production by monocytes/macrophages., [RefSeq, PubMed]; Tmem178 Negatively Regulates IL-1beta Production Through Inhibition of the NLRP3 Inflammasome., [RefSeq, PubMed]; Tmem178 localizes to the ER membrane and regulates RANKL-induced Ca(2+) fluxes, thus controlling NFATc1 induction, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9577, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F8VPV2;Q8CEU4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0051480 regulation of cytosolic calcium ion concentration;GO:0045671 negative regulation of osteoclast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CZ16-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DA32-1", "uniprot_id": [ { "id": "SUN5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DA32", "type": "external" } ], "mass": 42653.0, "length": 373, "protein_name": "SUN domain-containing protein 5", "gene_name": "Sun5", "organism": "Mouse", "refseq_name": "SUN domain-containing protein 5 isoform 1", "refseq_ac": [ { "id": "NP_001291977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291977", "type": "external" } ], "gene_names_uniprotkb": "Sun5; Spag4l", "gene_names_refseq": "1700021O15Rik; SPAG4L-2; SRG4; Spag4l; Sun5", "protein_names_uniprotkb": "SUN domain-containing protein 5; Sperm-associated antigen 4-like protein", "protein_names_refseq": "SUN domain-containing protein 5 isoform 1; SUN domain-containing protein 5; sperm-associated antigen 4-like protein; spermatogenesis-related gene 4", "tax_id": 10090, "disease": "spermatogenic failure 16 (Disease Ontology:DOID:0070184)", "pathway": " (mmu:76407)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "15552040;17618558;17650487;21159740;21711156;21750661;25775128;28945193;29298896;34389728;38870534", "class_list": "", "function": "Required for male fertility (PubMed:38870534). Plays an essential role in maintenance of sperm head-to-tail attachment during late stages of spermiogenesis, via promoting secure attachment of the nuclear envelope to the flagellum coupling apparatus (PubMed:28945193, PubMed:38870534). Component of the LMNB1/SUN5/SEPT12 bridge that connects the sperm proximal centriole to the implantation fossa, the bridge functions to prevent detachment of the proximal centriole from the posterior nucleus during in spermatids during spermiogenesis (PubMed:38870534). Required for localization of SEPT12 at the implantation fossa of sperm cells during spermiogenesis (PubMed:38870534)., [UniProtKB, PubMed, PubMed]; Results indicated that the expression of SRG4 was regulated by development, and SRG4 was mainly expressed in the cytoplasm of spermatocytes and round spermatids., [RefSeq, PubMed]; SPAG4L may play an important role in the meiotic stage of spermatogenesis, [RefSeq, PubMed]; SPAG4L-2 and SPAG4L are transmembrane proteins that localize to the nuclear envelope., [RefSeq, PubMed]; SRG4 was cloned into pUCm-T vectors and sequenced, subcloned into a prokaryotic expression vector and expression of induced by IPTG., [RefSeq, PubMed]; The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D2DR64;Q5DT38", "ec_number_list": [], "go_molecular_function": "GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005794 Golgi apparatus;GO:0005637 nuclear inner membrane;GO:0034993 meiotic nuclear membrane microtubule tethering complex;GO:0120212 sperm head-tail coupling apparatus", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007286 spermatid development;GO:0032880 regulation of protein localization;GO:0065003 protein-containing complex assembly;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9DA32-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPM5-1", "uniprot_id": [ { "id": "SYNCI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EPM5", "type": "external" } ], "mass": 53630.0, "length": 470, "protein_name": "Syncoilin", "gene_name": "Sync", "organism": "Mouse", "refseq_name": "syncoilin", "refseq_ac": [ { "id": "NP_075974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075974", "type": "external" } ], "gene_names_uniprotkb": "Sync; Sync1", "gene_names_refseq": "1110057H03Rik; SNIP4; Sync", "protein_names_uniprotkb": "Syncoilin; Syncoilin intermediate filament 1; Syncoilin-1", "protein_names_refseq": "syncoilin intermediate filament 1; syncoilin-1; syncoilin", "tax_id": 10090, "disease": "", "pathway": " (mmu:68828)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11053421;11694502;17629480;18367591;21183079;24043511;30016717;34052184", "class_list": "", "function": "Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins., [UniProtKB, PubMed, PubMed]; In the liver, syncoilin is predominantly expressed by activated Hepatic stellate cells and displays very low-expression levels in other liver cell types, making it a good marker of activated Hepatic stellate cells., [RefSeq, PubMed]; Single-cell brain atlas of Parkinson's disease mouse model., [RefSeq, PubMed]; Syncoilin may play a supportive role for desmin in the efficient coupling of mechanical stress between the myofibril and muscle fiber exterior., [RefSeq, PubMed]; The data show that absence of alpha-dystrobrevin or desmin leads to dynamic changes in syncoilin that may compensate for, or participate in, different muscle myopathies., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3KP79;Q3TKN1;Q3TUH9;Q8C4J4;Q9CT88", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031594 neuromuscular junction;GO:0048471 perinuclear region of cytoplasm;GO:0005882 intermediate filament", "go_biological_process": "GO:0045103 intermediate filament-based process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9EPM5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C1A5-1", "uniprot_id": [ { "id": "THOP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C1A5", "type": "external" } ], "mass": 78026.0, "length": 687, "protein_name": "Thimet oligopeptidase", "gene_name": "Thop1", "organism": "Mouse", "refseq_name": "thimet oligopeptidase", "refseq_ac": [ { "id": "NP_073144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073144", "type": "external" } ], "gene_names_uniprotkb": "Thop1", "gene_names_refseq": "EP24.15; Thop1", "protein_names_uniprotkb": "Thimet oligopeptidase; 3.4.24.15", "protein_names_refseq": "endopeptidase 24.15; thimet oligopeptidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:50492); (R-MMU-983168)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10969067;18034455;20456597;21183079;21750661;22645316;24216478;24788674;25153642;28528544;32079362;35820727;37507081", "class_list": "", "function": "Data show that Thimet oligopeptidase (TOP) is coexpressed with estrogen receptor alpha, and estradiol regulates TOP expression in a brain region-specific manner in female mice., [RefSeq, PubMed]; Involved in the metabolism of neuropeptides under 20 amino acid residues long (PubMed:10969067). Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (By similarity). Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments. Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1., [UniProtKB, UniProtKB]; The Relevance of Thimet Oligopeptidase in the Regulation of Energy Metabolism and Diet-Induced Obesity. Publication Status: Online-Only, [RefSeq, PubMed]; The cellular peptidases dipeptidyl peptidase 3 (DPP-3) and thimet oligopeptidase 1 (TOP-1), both of which are present in nonimmunogenic necrotic cells, eliminated proteasomal degradation products and blocked Ag cross-presentation, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0J9;Q8K2D4;Q9EPX1", "ec_number_list": [ { "id": "3.4.24.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.15", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0042277 peptide binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0035556 intracellular signal transduction;GO:0043171 peptide catabolic process;GO:0006518 peptide metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8C1A5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHV6-1", "uniprot_id": [ { "id": "TAD2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHV6", "type": "external" } ], "mass": 51339.0, "length": 443, "protein_name": "Transcriptional adapter 2-alpha", "gene_name": "Tada2a", "organism": "Mouse", "refseq_name": "transcriptional adapter 2-alpha", "refseq_ac": [ { "id": "NP_766150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766150", "type": "external" } ], "gene_names_uniprotkb": "Tada2a; Tada2l", "gene_names_refseq": "D030022J10Rik; Tada2a; Tada2l", "protein_names_uniprotkb": "Transcriptional adapter 2-alpha; ADA2-like protein; Transcriptional adapter 2-like", "protein_names_refseq": "ADA2-like protein; transcriptional adapter 2-alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:217031); (R-MMU-9772755)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "16299514;17428495;21750661;31219806;34065515", "class_list": "", "function": "Alpha-Synuclein A53T Binds to Transcriptional Adapter 2-Alpha and Blocks Histone H3 Acetylation. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA (PubMed:16299514). Binds dinucleosomes, probably at the linker region between neighboring nucleosomes (PubMed:16299514). Plays a role in chromatin remodeling (By similarity). May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (By similarity). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZD7;Q8BNK0;Q8R3H5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0070461 SAGA-type complex;GO:0005634 nucleus;GO:0000124 SAGA complex;GO:0072686 mitotic spindle;GO:0140672 ATAC complex", "go_biological_process": "GO:0090043 regulation of tubulin deacetylation;GO:0000278 mitotic cell cycle;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CHV6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01853-1", "uniprot_id": [ { "id": "TERA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q01853", "type": "external" } ], "mass": 89322.0, "length": 806, "protein_name": "Transitional endoplasmic reticulum ATPase", "gene_name": "Vcp", "organism": "Mouse", "refseq_name": "transitional endoplasmic reticulum ATPase", "refseq_ac": [ { "id": "NP_033529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033529", "type": "external" } ], "gene_names_uniprotkb": "Vcp", "gene_names_refseq": "3110001E05; CDC48; Vcp; p97/VCP; p97", "protein_names_uniprotkb": "Transitional endoplasmic reticulum ATPase; 15S Mg(2+)-ATPase p97 subunit; 3.6.4.6; TER ATPase; VCP; Valosin-containing protein", "protein_names_refseq": "15S Mg(2+)-ATPase p97 subunit; AAA ATPase p97; Inv protein; TER ATPase; homolog of yeast cdc48; transitional endoplasmic reticulum ATPase", "tax_id": 10090, "disease": "inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); frontotemporal dementia and/or amyotrophic lateral sclerosis 6 (Disease Ontology:DOID:0060205); Charcot-Marie-Tooth disease type 2Y (Disease Ontology:DOID:0110168); inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1 (Disease Ontology:DOID:0111385); neurodegenerative disease (Disease Ontology:DOID:1289); dementia (Disease Ontology:DOID:1307); inclusion body myositis (Disease Ontology:DOID:3429); Paget's disease of bone (Disease Ontology:DOID:5408); primary ovarian insufficiency (Disease Ontology:DOID:5426); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (mmu:269523); (R-MMU-110320); (R-MMU-3371511); (R-MMU-382556); (R-MMU-532668); (R-MMU-5358346); (R-MMU-5689877); (R-MMU-5689896); (R-MMU-6798695); (R-MMU-8876725); (R-MMU-8951664); (R-MMU-9013407); (R-MMU-9755511); (R-MMU-9931269)", "pathway_count": 14, "publication_count": 42, "publication_id_list": "11163219;12949490;1382975;14643202;14988733;15189447;15456787;15592455;15740751;16139798;16249333;16709668;17018057;17141156;21183079;22948820;23806337;24160817;25009997;25428506;26265139;26337389;26495903;26740625;29743287;30084848;31219806;33300544;33590678;34428180;35430615;35820727;36288343;36300783;37453647;37507081;37828378;38685170;38912971;38928151;39627609;39927985", "class_list": "", "function": "Cardiac-Specific Suppression of Valosin-Containing Protein Induces Progressive Heart Failure and Premature Mortality Correlating with Temporal Dysregulations in mTOR Complex 2 and Protein Phosphatase 1. Publication Status: Online-Only, [RefSeq, PubMed]; Dual role of valosin-containing protein (VCP/p97) in mouse sperm during capacitation. Publication Status: Online-Only, [RefSeq, PubMed]; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (By similarity). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Involved in clearance process by mediating G3BP1 extraction from stress granules (By similarity). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage. Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (By similarity). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (PubMed:33590678). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (By similarity). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation. Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy. Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI. May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation. May more particularly play a role in caveolins sorting in cells. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; Valosin-containing protein acts as a target and mediator of S-nitrosylation in the heart through distinct mechanisms., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TFH9;Q3TIM2;Q3TXN9;Q6PI18;Q8BSR6;Q8CEG4", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.5.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.52", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0140036 ubiquitin-modified protein reader activity;GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:1990730 VCP-NSFL1C complex;GO:0098978 glutamatergic synapse;GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0097352 autophagosome maturation;GO:2001171 positive regulation of ATP biosynthetic process;GO:1903006 positive regulation of protein K63-linked deubiquitination;GO:0043335 protein unfolding;GO:1905634 regulation of protein localization to chromatin", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "Q01853-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99KW3-3", "uniprot_id": [ { "id": "TARA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99KW3", "type": "external" } ], "mass": 223368.0, "length": 2014, "protein_name": "TRIO and F-actin-binding protein", "gene_name": "Triobp", "organism": "Mouse", "refseq_name": "TRIO and F-actin-binding protein isoform 4", "refseq_ac": [ { "id": "NP_001034244", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034244", "type": "external" } ], "gene_names_uniprotkb": "Triobp; Kiaa1662; Tara", "gene_names_refseq": "EST478828; Tara; Triobp; mKIAA1662", "protein_names_uniprotkb": "TRIO and F-actin-binding protein; Protein Tara; Trio-associated repeat on actin", "protein_names_refseq": "TRIO and F-actin-binding protein isoform 4; protein Tara; trio-associated repeat on actin", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 28 (Disease Ontology:DOID:0110486)", "pathway": " (mmu:110253)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "16385457;16385458;17242355;19144319;20510926;24129315;28135057;28209736;29187734;31217345;31219806;34418053;34428180;35175278;35737845", "class_list": "", "function": "ANKRD24 organizes TRIOBP to reinforce stereocilia insertion points., [RefSeq, PubMed]; May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TRIOBP and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover., [UniProtKB, UniProtKB]; Plays a pivotal role in the formation of rootlets., [UniProtKB, PubMed]; This gene encodes a protein that interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility, and cell growth. The encoded protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. Mutations in the human gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants have been described [provided by RefSeq, Sep 2012]., [RefSeq]; Unbalanced bidirectional radial stiffness gradients within the organ of Corti promoted by TRIOBP., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q2PZW9;Q2Q402;Q2Q403;Q2Q404;Q6ZPK4;Q8C6T3;Q8CG90", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0030496 midbody", "go_biological_process": "GO:0051301 cell division;GO:0051017 actin filament bundle assembly;GO:1900026 positive regulation of substrate adhesion-dependent cell spreading;GO:0007605 sensory perception of sound;GO:0060088 auditory receptor cell stereocilium organization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q99KW3-3", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJR8-1", "uniprot_id": [ { "id": "TMM9B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJR8", "type": "external" } ], "mass": 22607.0, "length": 199, "protein_name": "Transmembrane protein 9B", "gene_name": "Tmem9b", "organism": "Mouse", "refseq_name": "transmembrane protein 9B precursor", "refseq_ac": [ { "id": "NP_064434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064434", "type": "external" } ], "gene_names_uniprotkb": "Tmem9b", "gene_names_refseq": "2310004K06Rik; D7H11orf15; ICRFP703B1614Q5.3; Tmem9b", "protein_names_uniprotkb": "Transmembrane protein 9B", "protein_names_refseq": "ICRFP703N2430Q5.3; transmembrane protein 9B precursor; transmembrane protein 9B", "tax_id": 10090, "disease": "", "pathway": " (mmu:56786)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;11528127;19144319;21750661", "class_list": "", "function": "Enhances production of pro-inflammatory cytokines induced by TNF, IL1B, and TLR ligands. Has a role in TNF activation of both the NF-kappaB and MAPK pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0031901 early endosome membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JJR8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08122-3", "uniprot_id": [ { "id": "TLE3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08122", "type": "external" } ], "mass": 83447.0, "length": 772, "protein_name": "Transducin-like enhancer protein 3", "gene_name": "Tle3", "organism": "Mouse", "refseq_name": "transducin-like enhancer protein 3 isoform 1", "refseq_ac": [ { "id": "NP_001077396", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077396", "type": "external" } ], "gene_names_uniprotkb": "Tle3; Esg", "gene_names_refseq": "2610103N05Rik; ESG; Grg3a; Grg3b; Tle3; mKIAA1547", "protein_names_uniprotkb": "Transducin-like enhancer protein 3; ESG; Grg-3", "protein_names_refseq": "grg-3; transducin-like enhancer of split 3, homolog of Drosophila E(spl); transducin-like enhancer protein 3 isoform 1; transducin-like enhancer protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:21887); (R-MMU-201722); (R-MMU-3769402); (R-MMU-4641265); (R-MMU-9018519)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "11266540;15345747;17242355;17584735;18254933;21183079;21459326;23473036;23990468;29237092;32782141;36852467;37392376;38177411;40885482;8365415", "class_list": "", "function": "The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma., [RefSeq, PubMed]; Transcriptional coregulator that binds to a number of transcription factors (PubMed:21459326). Acts as a regulator of adipogenesis both by acting as a corepressor of Wnt signaling and coactivator for PPARG (PubMed:21459326, PubMed:23473036). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (By similarity). Promotes diffentiation of white adipocytes by acting as a coactivator for PPARG and preventing the association between PRDM16 and PPARG, thereby preventing browning of white adipocytes (PubMed:23473036)., [UniProtKB, UniProtKB, PubMed, PubMed]; Zeb1 and Tle3 are trans-factors that differentially regulate the expression of myosin heavy chain-embryonic and skeletal muscle differentiation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q6PHP0;Q923A4", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:1990907 beta-catenin-TCF complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0050872 white fat cell differentiation;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q08122-3", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQA1-1", "uniprot_id": [ { "id": "TPPC5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQA1", "type": "external" } ], "mass": 20795.0, "length": 188, "protein_name": "Trafficking protein particle complex subunit 5", "gene_name": "Trappc5", "organism": "Mouse", "refseq_name": "trafficking protein particle complex subunit 5", "refseq_ac": [ { "id": "NP_079977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079977", "type": "external" } ], "gene_names_uniprotkb": "Trappc5", "gene_names_refseq": "4021401A16Rik; TRS31; Trappc5", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 5", "protein_names_refseq": "trafficking protein particle complex subunit 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:66682); (R-MMU-204005); (R-MMU-8876198)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "25428506;30084848;31219806;34428180", "class_list": "", "function": "May play a role in vesicular transport from endoplasmic reticulum to Golgi., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJX6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:1990072 TRAPPIII protein complex;GO:1990070 TRAPPI protein complex;GO:0030008 TRAPP complex", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048208 COPII vesicle coating;GO:0006901 vesicle coating;GO:0099022 vesicle tethering", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CQA1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBS2-1", "uniprot_id": [ { "id": "TPRGL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBS2", "type": "external" } ], "mass": 29814.0, "length": 266, "protein_name": "Tumor protein p63-regulated gene 1-like protein", "gene_name": "Tprg1l", "organism": "Mouse", "refseq_name": "tumor protein p63-regulated gene 1-like protein", "refseq_ac": [ { "id": "NP_080664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080664", "type": "external" } ], "gene_names_uniprotkb": "Tprg1l; Fam79a; Mover; Tprgl", "gene_names_refseq": "1200015A19Rik; Svap30; Tprg1l; Tprgl; mover", "protein_names_uniprotkb": "Tumor protein p63-regulated gene 1-like protein; Mossy fiber terminal-associated vertebrate-specific presynaptic protein; Protein FAM79A", "protein_names_refseq": "mossy-fiber terminal-associated vertebrate-specific presynaptic protein; synaptic vesicle associated protein of 30 kD; transformation related protein 63 regulated like; tumor protein p63-regulated gene 1-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67808)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17114649;17869247;18256694;21183079;21750661;31787876;33431696;34428180", "class_list": "", "function": "Mover may act in concert with generally expressed scaffolding proteins in distinct sets of presynaptic terminals, [RefSeq, PubMed]; Presynaptic protein involved in the synaptic transmission tuning. Regulates synaptic release probability by decreasing the calcium sensitivity of release., [UniProtKB, UniProtKB]; Regulation of a subset of release-ready vesicles by the presynaptic protein Mover., [RefSeq, PubMed]; Tprgl is a ubiquitously expressed gene located upstream of the p73 gene. Its encoded protein displays 44% amino acid identity with the protein encoded by Tprg, a p63 target gene that is located upstream of the p63 gene., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AX99;Q8BTC6", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0044305 calyx of Held;GO:0005737 cytoplasm;GO:0048786 presynaptic active zone", "go_biological_process": "GO:0050805 negative regulation of synaptic transmission;GO:0051966 regulation of synaptic transmission, glutamatergic;GO:0033173 calcineurin-NFAT signaling cascade;GO:0016081 synaptic vesicle docking;GO:2000300 regulation of synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9DBS2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TS55-1", "uniprot_id": [ { "id": "TNF18_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TS55", "type": "external" } ], "mass": 19732.0, "length": 173, "protein_name": "Tumor necrosis factor ligand superfamily member 18", "gene_name": "Tnfsf18", "organism": "Mouse", "refseq_name": "tumor necrosis factor ligand superfamily member 18", "refseq_ac": [ { "id": "NP_899247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899247", "type": "external" } ], "gene_names_uniprotkb": "Tnfsf18; Gitrl", "gene_names_refseq": "Gitrl; Tnfsf18; Tnlg2a", "protein_names_uniprotkb": "Tumor necrosis factor ligand superfamily member 18; GITR ligand; GITRL; Glucocorticoid-induced TNF-related ligand", "protein_names_refseq": "GITR ligand; glucocorticoid-induced TNF-related ligand; glucocorticoid-induced-tumor necrosis factor receptor ligand; tumor necrosis factor ligand 2a; tumor necrosis factor ligand superfamily member 18", "tax_id": 10090, "disease": "", "pathway": " (mmu:240873); (R-MMU-5669034)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "14521928;14608036;14647196;15128759;15470044;18178614;18182486;19390148;23892569;24107315;34293591;36301339;38321001;38589318", "class_list": "", "function": "A GITRL-mTORC1-GM-CSF Positive Loop Promotes Pathogenic Th17 Response in Primary Sjogren Syndrome., [RefSeq, PubMed]; A soluble form of mouse GITR ligand (sGITR-L) induces GITR-dependent NF-kappa B activation and blocks in vitro suppression mediated by both resting and preactivated polyclonal and antigen-specific regulatory T (Treg) cells., [RefSeq, PubMed]; Blockade of GITRL/GITR signaling pathway attenuates house dust mite-induced allergic asthma in mice through inhibition of MAPKs and NF-kappaB signaling., [RefSeq, PubMed]; Cytokine that binds to TNFRSF18/AITR/GITR (PubMed:14521928, PubMed:14647196). Regulates T-cell responses (PubMed:14647196). Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation (PubMed:14608036, PubMed:15128759). Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B (PubMed:14521928, PubMed:14647196, PubMed:18178614). Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (By similarity). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (PubMed:24107315)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; GITR-L provides an important signal for CD25- T cells, rendering them resistant to CD25+ -mediated regulation at the initiation of the immune response., [RefSeq, PubMed]; GITRL impairs hepatocyte repopulation by liver progenitor cells to aggravate inflammation and fibrosis by GITR[+]CD8[+] T lymphocytes in CDE Mice. Publication Status: Online-Only, [RefSeq, PubMed]; GITRL impairs the immunosuppressive function of MDSCs via PTEN-mediated signaling pathway in experimental Sjogren syndrome., [RefSeq, PubMed]; Glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNY2;Q80YG2", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0032813 tumor necrosis factor receptor superfamily binding;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0045785 positive regulation of cell adhesion;GO:0090026 positive regulation of monocyte chemotaxis;GO:0002250 adaptive immune response;GO:0050729 positive regulation of inflammatory response;GO:0033209 tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q7TS55-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CB49-1", "uniprot_id": [ { "id": "TPRG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CB49", "type": "external" } ], "mass": 31269.0, "length": 279, "protein_name": "Tumor protein p63-regulated gene 1 protein", "gene_name": "Tprg1", "organism": "Mouse", "refseq_name": "tumor protein p63-regulated gene 1 protein", "refseq_ac": [ { "id": "NP_780374", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780374", "type": "external" } ], "gene_names_uniprotkb": "Tprg1; Fam79b; Tprg", "gene_names_refseq": "5430420C16Rik; Tprg1; Tprg", "protein_names_uniprotkb": "Tumor protein p63-regulated gene 1 protein; Protein FAM79B", "protein_names_refseq": "tumor protein p63-regulated gene 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:71338)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18256694", "class_list": "", "function": "Tprg gene is predominantly expressed in skin, is physically associated with the p63 gene during evolution, and directly regulated by p63 through a long-distance enhancer located within the Tprg locus. GeneRIF: The Tprg gene is predominantly expressed in keratinocytes, is physically associated with the p63 gene during evolution, and is directly regulated by p63 through a long-distance enhancer located within the Tprg locus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CB49-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SXI5-1", "uniprot_id": [ { "id": "ZN496_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SXI5", "type": "external" } ], "mass": 66577.0, "length": 585, "protein_name": "Zinc finger protein 496", "gene_name": "Znf496", "organism": "Mouse", "refseq_name": "zinc finger protein 496 isoform 2", "refseq_ac": [ { "id": "NP_001124001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124001", "type": "external" } ], "gene_names_uniprotkb": "Znf496; Nizp11; Zfp496; Zkscan17", "gene_names_refseq": "Nizp1; Zfp496; Zkscan17; Znf496", "protein_names_uniprotkb": "Zinc finger protein 496; NSD1-interacting zinc finger protein 1; Zinc finger protein with KRAB and SCAN domains 17", "protein_names_refseq": "NSD1-interacting zinc finger protein 1; zinc finger protein 496 isoform 2; zinc finger protein 496; zinc finger protein with KRAB and SCAN domains 17", "tax_id": 10090, "disease": "", "pathway": " (mmu:268417); (R-MMU-212436)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15169884;17521633;21183079;35820727", "class_list": "", "function": "A novel NSD1-interacting protein(Nizp1), [RefSeq, PubMed]; DNA-binding transcription factor that can both act as an activator and a repressor., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TC40;Q3UTL1;Q8BKK0;Q8CGF9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5SXI5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VM3-1", "uniprot_id": [ { "id": "WIPI4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VM3", "type": "external" } ], "mass": 39787.0, "length": 360, "protein_name": "WD repeat domain phosphoinositide-interacting protein 4", "gene_name": "Wdr45", "organism": "Mouse", "refseq_name": "WD repeat domain phosphoinositide-interacting protein 4 isoform a", "refseq_ac": [ { "id": "NP_001277721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277721", "type": "external" } ], "gene_names_uniprotkb": "Wdr45; DXImx38e; Wdrx1; Wipi4", "gene_names_refseq": "DXImx38e; JM5; Sfc19; WIPI-4; Wdr45; Wdrx1", "protein_names_uniprotkb": "WD repeat domain phosphoinositide-interacting protein 4; WD repeat domain X-linked 1; WD repeat-containing protein 45; WIPI-4", "protein_names_refseq": "WD repeat domain phosphoinositide-interacting protein 4 isoform a; WD repeat domain phosphoinositide-interacting protein 4; WD repeat domain, X-linked 1; WD repeat-containing protein 45", "tax_id": 10090, "disease": "neurodegeneration with brain iron accumulation 5 (Disease Ontology:DOID:0110739)", "pathway": " (mmu:54636); (R-MMU-1632852)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10857745;18250455;21750661;21952136;26000824;31204559;31219806;31238825;34043061;34428180;34799629;35820727;37828378;39183331", "class_list": "", "function": "A comprehensive phenotypic characterization of a whole-body Wdr45 knock-out mouse., [RefSeq, PubMed]; Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Probably recruited to membranes through its PtdIns3P activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Nes-Wdr45(fl/Y) mice recapitulate some hallmarks of beta-propeller protein-associated neurodegeneration, including cognitive impairment and defective axonal homeostasis, [RefSeq, PubMed]; Pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency. Publication Status: Online-Only, [RefSeq, PubMed]; Physiological significance of WDR45, a responsible gene for beta-propeller protein associated neurodegeneration (BPAN), in brain development. Publication Status: Online-Only, [RefSeq, PubMed]; Role of Wdr45b in maintaining neural autophagy and cognitive function., [RefSeq, PubMed]; WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AEV3;A2AEV4;Q9CVF7;Q9JIG9", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:1901981 phosphatidylinositol phosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005829 cytosol;GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006914 autophagy;GO:0034497 protein localization to phagophore assembly site;GO:0009267 cellular response to starvation;GO:0000422 autophagy of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q91VM3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJG7-1", "uniprot_id": [ { "id": "ISPD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5RJG7", "type": "external" } ], "mass": 49136.0, "length": 447, "protein_name": "D-ribitol-5-phosphate cytidylyltransferase", "gene_name": "Crppa", "organism": "Mouse", "refseq_name": "D-ribitol-5-phosphate cytidylyltransferase isoform 2", "refseq_ac": [ { "id": "NP_001276431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276431", "type": "external" } ], "gene_names_uniprotkb": "Crppa; Ispd", "gene_names_refseq": "4930579E17Rik; Crppa; Ispd", "protein_names_uniprotkb": "D-ribitol-5-phosphate cytidylyltransferase; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein; 2.7.7.40; Isoprenoid synthase domain-containing protein", "protein_names_refseq": "2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein; D-ribitol-5-phosphate cytidylyltransferase isoform 2; D-ribitol-5-phosphate cytidylyltransferase; isoprenoid synthase domain containing; isoprenoid synthase domain-containing protein; notch1-induced protein", "tax_id": 10090, "disease": "Walker-Warburg syndrome (Disease Ontology:DOID:0050560); autosomal recessive limb-girdle muscular dystrophy type 2U (Disease Ontology:DOID:0110295); congenital muscular dystrophy-dystroglycanopathy type A7 (Disease Ontology:DOID:0111234)", "pathway": " (mmu:75847); (R-MMU-9939291)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;23161489;23217742;30059200", "class_list": "", "function": "Cytidylyltransferase required for protein O-linked mannosylation (By similarity). Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate (By similarity). CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity). Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively (By similarity). Not involved in dolichol production (By similarity)., [UniProtKB, UniProtKB]; Cytidylyltransferase required for protein O-linked mannosylation. Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate. CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively. Not involved in dolichol production., [UniProtKB, UniProtKB, UniProtKB]; This study demonistrated that the axonal guidance defects observed in ispd mutant mice., [RefSeq, PubMed]; We show that activated NOTCH1 and ZMIZ1 collaborate to induce T-ALL in mice, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q148Q0;Q501J8;Q8BR14;Q8C934;Q8CAE0;Q8CIF0", "ec_number_list": [ { "id": "2.7.7.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.40", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0047349 D-ribitol-5-phosphate cytidylyltransferase activity;GO:0070567 cytidylyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0007411 axon guidance;GO:0035269 protein O-linked glycosylation via mannose;GO:0008299 isoprenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5RJG7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D565-1", "uniprot_id": [ { "id": "WDR64_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D565", "type": "external" } ], "mass": 123893.0, "length": 1086, "protein_name": "WD repeat-containing protein 64", "gene_name": "Wdr64", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Wdr64", "gene_names_refseq": "", "protein_names_uniprotkb": "WD repeat-containing protein 64", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:75820)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;39386799", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CUP8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D565-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWY2-1", "uniprot_id": [ { "id": "CLC1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWY2", "type": "external" } ], "mass": 30958.0, "length": 269, "protein_name": "C-type lectin domain family 1 member A", "gene_name": "Clec1a", "organism": "Mouse", "refseq_name": "C-type lectin domain family 1 member A isoform 2", "refseq_ac": [ { "id": "NP_001334404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334404", "type": "external" } ], "gene_names_uniprotkb": "Clec1a", "gene_names_refseq": "5930406N14Rik; Clec1a", "protein_names_uniprotkb": "C-type lectin domain family 1 member A", "protein_names_refseq": "C-type lectin domain family 1 member A isoform 2", "tax_id": 10090, "disease": "aspergillosis (Disease Ontology:DOID:13564)", "pathway": " (mmu:243653)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;35135958", "class_list": "glycogene", "function": "The C-type lectin receptor Clec1A plays an important role in the development of experimental autoimmune encephalomyelitis by enhancing antigen presenting ability of dendritic cells and inducing inflammatory cytokine IL-17., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPX7;Q8BMH5", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0030246 carbohydrate binding;GO:0030545 signaling receptor regulator activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007165 signal transduction;GO:0050832 defense response to fungus;GO:0008037 cell recognition", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BWY2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CYT6-1", "uniprot_id": [ { "id": "CAP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CYT6", "type": "external" } ], "mass": 52862.0, "length": 476, "protein_name": "Adenylyl cyclase-associated protein 2", "gene_name": "Cap2", "organism": "Mouse", "refseq_name": "adenylyl cyclase-associated protein 2", "refseq_ac": [ { "id": "NP_080332", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080332", "type": "external" } ], "gene_names_uniprotkb": "Cap2", "gene_names_refseq": "2810452G09Rik; Cap2", "protein_names_uniprotkb": "Adenylyl cyclase-associated protein 2; CAP 2", "protein_names_refseq": "CAP, adenylate cyclase-associated protein, 2; adenylyl cyclase-associated protein 2", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:67252)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17114649;17805484;21750661;26616005;34428180;37507081;37863260;39927985", "class_list": "", "function": "CAP2 is significantly expressed only in brain, heart and skeletal muscle, and skin, a C-terminal fragment of CAP2 interacts with actin, indicating that CAP2 has the capacity to bind to actin, [RefSeq, PubMed]; Cyclase-associated protein interacts with actin filament barbed ends to promote depolymerization and formin displacement., [RefSeq, PubMed]; Involved in the regulation of actin polymerization., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80YU7;Q9D6L0", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0042802 identical protein binding;GO:0008179 adenylate cyclase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0098794 postsynapse", "go_biological_process": "GO:0007015 actin filament organization;GO:0000902 cell morphogenesis;GO:0099140 presynaptic actin cytoskeleton organization;GO:1905274 regulation of modification of postsynaptic actin cytoskeleton;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9CYT6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80UN1-1", "uniprot_id": [ { "id": "KCTD9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80UN1", "type": "external" } ], "mass": 36994.0, "length": 339, "protein_name": "BTB/POZ domain-containing protein KCTD9", "gene_name": "Kctd9", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing protein KCTD9 isoform a", "refseq_ac": [ { "id": "NP_001104498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104498", "type": "external" } ], "gene_names_uniprotkb": "Kctd9", "gene_names_refseq": "Kctd9", "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD9", "protein_names_refseq": "BTB/POZ domain-containing protein KCTD9 isoform a; BTB/POZ domain-containing protein KCTD9", "tax_id": 10090, "disease": "", "pathway": " (mmu:105440)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;22433305;29940856;31024568;31219806", "class_list": "", "function": "A novel potassium channel gene KCTD9 was highly expressed in hepatic NK cells and T cells of fulminant hepatitis mice induced by MHV-3., [RefSeq, PubMed]; Interference with potassium channel tetramerisation domain containing 9 (KCTD9) expression exert beneficial effect in viral fulminant hepatitis therapy, which may be mediated by impairment of NK cell activation. Publication Status: Online-Only, [RefSeq, PubMed]; Kctd9 Deficiency Impairs Natural Killer Cell Development and Effector Function. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLH9;Q3TY35", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0097602 cullin family protein binding", "go_cellular_component": "", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0035556 intracellular signal transduction;GO:0051260 protein homooligomerization;GO:0009615 response to virus;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80UN1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81066-1", "uniprot_id": [ { "id": "IRX2_MOUSE", "url": "https://www.uniprot.org/uniprot/P81066", "type": "external" } ], "mass": 49484.0, "length": 474, "protein_name": "Iroquois-class homeodomain protein IRX-2", "gene_name": "Irx2", "organism": "Mouse", "refseq_name": "iroquois-class homeodomain protein IRX-2", "refseq_ac": [ { "id": "NP_034704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034704", "type": "external" } ], "gene_names_uniprotkb": "Irx2; Irx6; Irxa2", "gene_names_refseq": "Irx2", "protein_names_uniprotkb": "Iroquois-class homeodomain protein IRX-2; Homeodomain protein IRXA2; Iroquois homeobox protein 2; Iroquois-class homeobox protein Irx6", "protein_names_refseq": "Iroquois related homeobox 2; homeodomain protein IRXA2; iroquois homeobox protein 2; iroquois-class homeodomain protein IRX-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:16372)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10704856;10926765;17875669;21750661;9486539", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O55121;Q3UFG3;Q9ERN1;Q9JLL4", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0072086 specification of loop of Henle identity;GO:0072272 proximal/distal pattern formation involved in metanephric nephron development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P81066-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BND3-1", "uniprot_id": [ { "id": "WDR35_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BND3", "type": "external" } ], "mass": 133991.0, "length": 1181, "protein_name": "WD repeat-containing protein 35", "gene_name": "Wdr35", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 35 isoform 2", "refseq_ac": [ { "id": "NP_001152999", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152999", "type": "external" } ], "gene_names_uniprotkb": "Wdr35", "gene_names_refseq": "4930459M12Rik; 4931430C06; Wdr35; mKIAA1336", "protein_names_uniprotkb": "WD repeat-containing protein 35", "protein_names_refseq": "WD repeat-containing protein 35 isoform 2; WD repeat-containing protein 35", "tax_id": 10090, "disease": "cranioectodermal dysplasia 2 (Disease Ontology:DOID:0080804); short-rib thoracic dysplasia 7 with or without polydactyly (Disease Ontology:DOID:0110090); Ellis-Van Creveld syndrome (Disease Ontology:DOID:12714); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (mmu:74682); (R-MMU-5610787); (R-MMU-5620924)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21473986;21750661;25428506;30084848;34428180;34734804;39853433", "class_list": "", "function": "A WDR35-dependent coat protein complex transports ciliary membrane cargo vesicles to cilia. Publication Status: Online-Only, [RefSeq, PubMed]; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking (PubMed:21473986). May promote CASP3 activation and TNF-stimulated apoptosis (By similarity)., [UniProtKB, PubMed, UniProtKB]; In a mutation screen for developmental phenotypes, we identified a mutation in Wdr35 as the cause of midgestation lethality, with abnormalities characteristic of defects in the Hedgehog signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QLW3;Q8CDL4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0005930 axoneme;GO:0036064 ciliary basal body;GO:0030991 intraciliary transport particle A", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:1990830 cellular response to leukemia inhibitory factor;GO:0045907 positive regulation of vasoconstriction;GO:0060271 cilium assembly;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BND3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWR1-1", "uniprot_id": [ { "id": "WDR73_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWR1", "type": "external" } ], "mass": 40856.0, "length": 371, "protein_name": "Integrator complex assembly factor WDR73", "gene_name": "Wdr73", "organism": "Mouse", "refseq_name": "integrator complex assembly factor WDR73", "refseq_ac": [ { "id": "NP_082302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082302", "type": "external" } ], "gene_names_uniprotkb": "Wdr73", "gene_names_refseq": "1200011I23Rik; 2410008B13Rik; Wdr73", "protein_names_uniprotkb": "Integrator complex assembly factor WDR73; WD repeat-containing protein 73", "protein_names_refseq": "WD repeat-containing protein 73; integrator complex assembly factor WDR73", "tax_id": 10090, "disease": "Galloway-Mowat syndrome 1 (Disease Ontology:DOID:0060364)", "pathway": " (mmu:71968)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex. Associates with INTS9 and INTS11 in the cytoplasm, stabilizing the INTS9-INTS11 heterodimer and blocking the active site of INTS11. BRAT1 then joins the complex and plugs the active site of INTS11, leading to WDR73 release and nuclear import of INTS9 and INTS11., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q05C70;Q3TEN7;Q571I2;Q8BSB9;Q8CF62", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032154 cleavage furrow", "go_biological_process": "GO:0006997 nucleus organization;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CWR1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQK1-1", "uniprot_id": [ { "id": "INT7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQK1", "type": "external" } ], "mass": 106861.0, "length": 966, "protein_name": "Integrator complex subunit 7", "gene_name": "Ints7", "organism": "Mouse", "refseq_name": "integrator complex subunit 7 isoform 2", "refseq_ac": [ { "id": "NP_001293132", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001293132", "type": "external" } ], "gene_names_uniprotkb": "Ints7", "gene_names_refseq": "5930412E23Rik; Ints7; int7", "protein_names_uniprotkb": "Integrator complex subunit 7; Int7", "protein_names_refseq": "integrator complex subunit 7 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:77065); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21750661;22872234;30084848;31219806;34203471;34428180;39627609", "class_list": "", "function": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex. Plays a role in DNA damage response (DDR) signaling during the S phase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C3A9;Q8C3N4;Q8C3N6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0005694 chromosome;GO:0032039 integrator complex", "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0071479 cellular response to ionizing radiation;GO:0000077 DNA damage checkpoint signaling;GO:0016180 snRNA processing;GO:0034472 snRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q7TQK1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69ZQ2-1", "uniprot_id": [ { "id": "ISY1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69ZQ2", "type": "external" } ], "mass": 32989.0, "length": 285, "protein_name": "Pre-mRNA-splicing factor ISY1 homolog", "gene_name": "Isy1", "organism": "Mouse", "refseq_name": "pre-mRNA-splicing factor ISY1 homolog isoform 2", "refseq_ac": [ { "id": "NP_598695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598695", "type": "external" } ], "gene_names_uniprotkb": "Isy1; Kiaa1160", "gene_names_refseq": "5830446M03Rik; Isy1", "protein_names_uniprotkb": "Pre-mRNA-splicing factor ISY1 homolog", "protein_names_refseq": "pre-mRNA-splicing factor ISY1 homolog isoform 2; pre-mRNA-splicing factor ISY1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:57905); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-72163)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "21750661;26255770;29804889", "class_list": "", "function": "Component of the spliceosome C complex required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation (PubMed:26255770, PubMed:29804889). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (PubMed:26255770). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (PubMed:29804889). Required during the transition of embryonic stem cells (ESCs) from the naive to primed state (PubMed:29804889). By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an intermediate state of poised pluripotency, which precedes the transition to the primed state (PubMed:29804889). Involved in pre-mRNA splicing as component of the spliceosome., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VDX4;Q9D3E2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0071014 post-mRNA release spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000350 generation of catalytic spliceosome for second transesterification step;GO:0000389 mRNA 3'-splice site recognition", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q69ZQ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLK3-1", "uniprot_id": [ { "id": "CABP5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLK3", "type": "external" } ], "mass": 19730.0, "length": 173, "protein_name": "Calcium-binding protein 5", "gene_name": "Cabp5", "organism": "Mouse", "refseq_name": "calcium-binding protein 5 isoform 1", "refseq_ac": [ { "id": "NP_038905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038905", "type": "external" } ], "gene_names_uniprotkb": "Cabp5", "gene_names_refseq": "Cabp5", "protein_names_uniprotkb": "Calcium-binding protein 5; CaBP5", "protein_names_refseq": "calcium-binding protein 5 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:29865)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10625670;17947313;18586882;21750661;22039235", "class_list": "", "function": "Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials (PubMed:18586882). Involved in the transmission of light signals (PubMed:18586882). May positively regulate neurotransmitter vesicle endocytosis and exocytosis in a salt-dependent manner (PubMed:22039235). May play a role in the extension and network organization of neurites (PubMed:22039235)., [UniProtKB, PubMed, PubMed]; This study shows that CaBP5 interacts with Munc18-1 and myosin VI, two proteins involved in the synaptic vesicle cycle stimulating neurite outgrowth and vesicle exocytosis Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005246 calcium channel regulator activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0007601 visual perception;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JLK3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q3K4-1", "uniprot_id": [ { "id": "E9Q3K4_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q3K4", "type": "external" } ], "mass": 7298.0, "length": 67, "protein_name": "Small integral membrane protein 10 like 1", "gene_name": "Smim10l1", "organism": "Mouse", "refseq_name": "small integral membrane protein 10-like protein 1 isoform 3", "refseq_ac": [ { "id": "NP_001156917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156917", "type": "external" } ], "gene_names_uniprotkb": "Smim10l1; 2700089E24Rik", "gene_names_refseq": "2700089E24Rik; Smim10l1", "protein_names_uniprotkb": "Small integral membrane protein 10 like 1", "protein_names_refseq": "small integral membrane protein 10-like protein 1 isoform 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:381820)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q3K4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q349-1", "uniprot_id": [ { "id": "WDR25_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q349", "type": "external" } ], "mass": 58480.0, "length": 535, "protein_name": "WD repeat-containing protein 25", "gene_name": "Wdr25", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 25", "refseq_ac": [ { "id": "NP_808270", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808270", "type": "external" } ], "gene_names_uniprotkb": "Wdr25", "gene_names_refseq": "B930090D16Rik; Wdr25", "protein_names_uniprotkb": "WD repeat-containing protein 25", "protein_names_refseq": "WD repeat-containing protein 25", "tax_id": 10090, "disease": "", "pathway": " (mmu:212198)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C4T7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9Q349-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CJ53-1", "uniprot_id": [ { "id": "CIP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CJ53", "type": "external" } ], "mass": 68489.0, "length": 603, "protein_name": "Cdc42-interacting protein 4", "gene_name": "Trip10", "organism": "Mouse", "refseq_name": "cdc42-interacting protein 4 isoform 1", "refseq_ac": [ { "id": "NP_001229318", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229318", "type": "external" } ], "gene_names_uniprotkb": "Trip10; Cip4", "gene_names_refseq": "Cip4; Trip10", "protein_names_uniprotkb": "Cdc42-interacting protein 4; TR-interacting protein 10; TRIP-10; Thyroid receptor-interacting protein 10", "protein_names_refseq": "Cdc42 interacting protein-4; TR-interacting protein 10; TRIP-10; cdc42-interacting protein 4 isoform 1; cdc42-interacting protein 4; thyroid receptor-interacting protein 10", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (mmu:106628); (R-MMU-8856828); (R-MMU-9013406)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "12054674;12242347;16418535;16735024;17189207;21183079;21750661;22920438;23572514;23881916;28720386;34428180", "class_list": "", "function": "CIP4 coordinates with phospholipids and actin-associated proteins to localize to the protruding edge and produce actin ribs and veils., [RefSeq, PubMed]; CIP4 is a new component in the highly coordinated system of megakaryocytic membrane and cytoskeletal remodeling affecting platelet production., [RefSeq, PubMed]; CIP4 silencing can efficiently alleviate Streptozotocin-induced pulmonary fibrosis in mice, perhaps through suppressing Wnt/GSK-3beta/beta-catenin signaling., [RefSeq, PubMed]; Data suggest that down-regulation of CIP4 in osteosarcoma changes cell morphology (reduces actin; alters cytoskeleton), inhibits primary tumor growth, impairs invasiveness and migration of tumor cells, delays metastasis, and prolongs survival time., [RefSeq, PubMed]; Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms (CIP4), [RefSeq, PubMed]; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL (By similarity). Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTR8;Q8R433;Q99LI0", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005874 microtubule;GO:0005938 cell cortex", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0001837 epithelial to mesenchymal transition;GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development;GO:0010667 negative regulation of cardiac muscle cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8CJ53-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AUY3-1", "uniprot_id": [ { "id": "B1AUY3_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AUY3", "type": "external" } ], "mass": 107603.0, "length": 965, "protein_name": "Rho GTPase activating protein 4", "gene_name": "Arhgap4", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Arhgap4", "gene_names_refseq": "", "protein_names_uniprotkb": "Rho GTPase activating protein 4", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:171207); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0030426 growth cone", "go_biological_process": "GO:0007165 signal transduction;GO:0010764 negative regulation of fibroblast migration;GO:0007399 nervous system development;GO:0030336 negative regulation of cell migration;GO:0051963 regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1AUY3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AVD1-1", "uniprot_id": [ { "id": "XPP2_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AVD1", "type": "external" } ], "mass": 76434.0, "length": 674, "protein_name": "Xaa-Pro aminopeptidase 2", "gene_name": "Xpnpep2", "organism": "Mouse", "refseq_name": "xaa-Pro aminopeptidase 2 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001276658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276658", "type": "external" } ], "gene_names_uniprotkb": "Xpnpep2", "gene_names_refseq": "9030008G12Rik; Xpnpep2; mAPP", "protein_names_uniprotkb": "Xaa-Pro aminopeptidase 2; 3.4.11.9; Membrane-bound APP; Membrane-bound aminopeptidase P; X-prolyl aminopeptidase 2; mAPP", "protein_names_refseq": "X-prolyl aminopeptidase 2; membrane-bound APP; membrane-bound aminopeptidase P; xaa-Pro aminopeptidase 2 isoform 2 precursor; xaa-Pro aminopeptidase 2", "tax_id": 10090, "disease": "acquired angioedema (Disease Ontology:DOID:0080941)", "pathway": " (mmu:170745); (R-MMU-163125)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;12941294;21750661", "class_list": "", "function": "Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3TA51;Q3TPA9;Q8BVD6;Q91Y31;Q91ZH9", "ec_number_list": [ { "id": "3.4.11.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.9", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.1.4.50", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.50", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.4.17.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.12", "type": "external" }, { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0098552 side of membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "B1AVD1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TEK5-1", "uniprot_id": [ { "id": "VKORL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6TEK5", "type": "external" } ], "mass": 19779.0, "length": 176, "protein_name": "Vitamin K epoxide reductase complex subunit 1-like protein 1", "gene_name": "Vkorc1l1", "organism": "Mouse", "refseq_name": "vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 1", "refseq_ac": [ { "id": "NP_081397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081397", "type": "external" } ], "gene_names_uniprotkb": "Vkorc1l1", "gene_names_refseq": "2310024K08Rik; Vkorc1l1", "protein_names_uniprotkb": "Vitamin K epoxide reductase complex subunit 1-like protein 1; 1.17.4.4; VKORC1-like protein 1", "protein_names_refseq": "VKORC1-like protein 1; vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 1; vitamin K epoxide reductase complex subunit 1-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69568); (R-MMU-6806664)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14765194;21750661;23928358;25747820;29321368;29963761;30084848;34428180;37467745", "class_list": "", "function": "Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K, and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins., [UniProtKB, PubMed]; Molecular cloning, [RefSeq, PubMed]; Quantified mRNA levels for VKORC1, VKORC1L1, GGCX, and NQO1 and measured VKOR enzymatic activities in 29 different tissues, [RefSeq, PubMed]; Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism., [RefSeq, PubMed]; The involvement of VKORC1L1 in VKOR activity partly explains the low susceptibility of some extrahepatic tissues to vitamin K antagonists., [RefSeq, PubMed]; VKORC1L1 supports vitamin K-dependent (VKD) protein protein carboxylation in vivo. Publication Status: Online-Only, [RefSeq, PubMed]; Vkorc1l1 promotes adipogenesis and possibly obesity. Downregulation of Vkorc1l1 increases intracellular vitamin K2 level and impedes preadipocyte differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q05AD4", "ec_number_list": [ { "id": "1.17.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.17.4.4", "type": "external" } ], "go_molecular_function": "GO:0047057 vitamin-K-epoxide reductase (warfarin-sensitive) activity;GO:0048038 quinone binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0017187 peptidyl-glutamic acid carboxylation;GO:0042373 vitamin K metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6TEK5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23906-1", "uniprot_id": [ { "id": "IRF2_MOUSE", "url": "https://www.uniprot.org/uniprot/P23906", "type": "external" } ], "mass": 39453.0, "length": 349, "protein_name": "Interferon regulatory factor 2", "gene_name": "Irf2", "organism": "Mouse", "refseq_name": "interferon regulatory factor 2", "refseq_ac": [ { "id": "NP_032417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032417", "type": "external" } ], "gene_names_uniprotkb": "Irf2", "gene_names_refseq": "9830146E22Rik; Irf-2; Irf2", "protein_names_uniprotkb": "Interferon regulatory factor 2; IRF-2", "protein_names_refseq": "interferon regulatory factor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:16363)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10487755;21750661;2208287;2475256;29899829;34428180;34488926;34878155;35088417;38194130;8402903;8475044;9562558", "class_list": "", "function": "DNA-binding transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible genes and regulates their expression (PubMed:2208287, PubMed:2475256, PubMed:8402903, PubMed:8475044). Mainly acts as a transcription repressor, repressing expression (PubMed:2208287, PubMed:2475256). Also acts as an activator for several genes including H4 and IL7 (By similarity). Constitutively binds to the ISRE promoter to activate IL7 (By similarity). Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth (By similarity). Antagonizes IRF1 transcriptional activation (PubMed:2208287, PubMed:2475256)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Effect of interferon regulatory factor 2 on inflammatory response and oxidative stress in lipopolysaccharide-induced acute kidney injury., [RefSeq, PubMed]; IRF2 contributes to myocardial infarction via regulation of GSDMD induced pyroptosis., [RefSeq, PubMed]; IRF2 enhances RANKL-induced osteoclast differentiation via regulating NF-kappaB/NFATc1 signaling., [RefSeq, PubMed]; Mesenchymal stem cells (MSCs) from the mouse bone marrow show differential expression of interferon regulatory factors IRF-1 and IRF-2. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0030054 cell junction", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P23906-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q4R4-1", "uniprot_id": [ { "id": "E9Q4R4_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q4R4", "type": "external" } ], "mass": 63944.0, "length": 555, "protein_name": "Zinc finger protein 882", "gene_name": "Zfp882", "organism": "Mouse", "refseq_name": "zinc finger protein 882", "refseq_ac": [ { "id": "NP_001160117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160117", "type": "external" } ], "gene_names_uniprotkb": "Zfp882", "gene_names_refseq": "Gm15468; Zfp882", "protein_names_uniprotkb": "Zinc finger protein 882", "protein_names_refseq": "zinc finger protein 882", "tax_id": 10090, "disease": "", "pathway": " (mmu:382019); (R-MMU-212436)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q4R4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJZ8-1", "uniprot_id": [ { "id": "CNGA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJZ8", "type": "external" } ], "mass": 72702.0, "length": 631, "protein_name": "Cyclic nucleotide-gated channel alpha-3", "gene_name": "Cnga3", "organism": "Mouse", "refseq_name": "cyclic nucleotide-gated channel alpha-3 isoform 1", "refseq_ac": [ { "id": "NP_001268939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268939", "type": "external" } ], "gene_names_uniprotkb": "Cnga3; Cng3", "gene_names_refseq": "CNG-3; CNG3; Cnga3", "protein_names_uniprotkb": "Cyclic nucleotide-gated channel alpha-3; CNG channel alpha-3; CNG-3; CNG3; CNGgust; Cone photoreceptor cGMP-gated channel subunit alpha-3; Gustatory cyclic nucleotide-gated cation channel", "protein_names_refseq": "CNG channel alpha-3; CNGgust; cone photoreceptor cGMP-gated channel subunit alpha-3; cone photoreceptor cGMP-gated channel subunit alpha; cyclic nucleotide-gated cation channel alpha-3; cyclic nucleotide-gated channel alpha-3 isoform 1; cyclic nucleotide-gated channel subunit alpha 3; gustatory cyclic nucleotide-gated cation channel", "tax_id": 10090, "disease": "achromatopsia 2 (Disease Ontology:DOID:0110007); color blindness (Disease Ontology:DOID:13399)", "pathway": " (mmu:12790)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10377453;10662822;10813773;11764791;21750661", "class_list": "", "function": "Pore-forming subunit of the cone cyclic nucleotide-gated channel. Mediates cone photoresponses at bright light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade (By similarity) (PubMed:10377453, PubMed:10662822). Pore-forming subunit of the gustatory cyclic nucleotide-gated channel. In the taste buds, may sense oral extracellular pH and conduct ion currents that modulate the excitability of taste cells (By similarity). Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFV6;Q9WV01", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0045296 cadherin binding;GO:0017022 myosin binding;GO:0005223 intracellularly cGMP-activated cation channel activity;GO:0005272 sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043204 perikaryon;GO:0043194 axon initial segment", "go_biological_process": "GO:0034220 monoatomic ion transmembrane transport;GO:0051899 membrane depolarization;GO:0007601 visual perception;GO:0060041 retina development in camera-type eye;GO:0098655 monoatomic cation transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JJZ8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1P4-1", "uniprot_id": [ { "id": "CHRD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1P4", "type": "external" } ], "mass": 37351.0, "length": 331, "protein_name": "Cysteine and histidine-rich domain-containing protein 1", "gene_name": "Chordc1", "organism": "Mouse", "refseq_name": "cysteine and histidine-rich domain-containing protein 1", "refseq_ac": [ { "id": "NP_080120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080120", "type": "external" } ], "gene_names_uniprotkb": "Chordc1; Chp1; Morgana", "gene_names_refseq": "1110001O09Rik; Chordc1; Chp-1; morgana", "protein_names_uniprotkb": "Cysteine and histidine-rich domain-containing protein 1; CHORD domain-containing protein 1; CHORD-containing protein 1; Chp-1; Protein morgana", "protein_names_refseq": "CHORD domain-containing protein 1; CHORD-containing protein 1; cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1; cysteine and histidine-rich domain-containing protein 1; protein morgana", "tax_id": 10090, "disease": "chronic myeloid leukemia (Disease Ontology:DOID:8552)", "pathway": " (mmu:66917)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "12965203;15642353;16083881;17242355;17253150;20230755;20493909;21750661;22872234;23184943;24615293;25678499;29158506;31599954;34428180;36210013", "class_list": "", "function": "Chp-1 and melusin can interact with cochaperones PP5 and Sgt1 and with each other in an ATP-dependent manner, [RefSeq, PubMed]; Full length sequence, gene structure and expression of Chp-1., [RefSeq, PubMed]; Loss of Morgana expression is associated with drug resistance and chronic myeloid leukemia., [RefSeq, PubMed]; Morgana causes PTEN destabilization, by inhibiting ROCK activity, [RefSeq, PubMed]; Morgana silencing blocks metastasis formation in breast cancer mouse models and this phenotype is reverted by IkappaBalpha downregulation. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755). Proposed to act as co-chaperone for HSP90 (PubMed:16083881). May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed:16083881). In vitro, has intrinsic chaperone activity (PubMed:20230755). This function may be achieved by inhibiting association of ROCK2 with NPM1 (PubMed:20230755). Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (By similarity). Involved in stress response (PubMed:20493909). Prevents tumorigenesis (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling. Involved in stress response. Prevents tumorigenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results suggest that Chordc1 mRNA is under complex and widespread transcriptional regulation during development and implicate Chordc1 in circadian and/or homeostatic mechanisms in mammalian brain., [RefSeq, PubMed]; The first biochemical evidence demonstrating that mammalian Chp-1 is a novel Hsp90-interacting protein., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CSI5", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0043531 ADP binding;GO:0051879 Hsp90 protein binding", "go_cellular_component": "", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:2000299 negative regulation of Rho-dependent protein serine/threonine kinase activity;GO:1900034 regulation of cellular response to heat;GO:0006457 protein folding;GO:0051298 centrosome duplication", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9D1P4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ80-1", "uniprot_id": [ { "id": "VPS25_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ80", "type": "external" } ], "mass": 20748.0, "length": 176, "protein_name": "Vacuolar protein-sorting-associated protein 25", "gene_name": "Vps25", "organism": "Mouse", "refseq_name": "vacuolar protein-sorting-associated protein 25 isoform 1", "refseq_ac": [ { "id": "NP_001271340", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271340", "type": "external" } ], "gene_names_uniprotkb": "Vps25; D11Wsu68e", "gene_names_refseq": "1110020N13Rik; D11Wsu68e; Vps25", "protein_names_uniprotkb": "Vacuolar protein-sorting-associated protein 25; ESCRT-II complex subunit VPS25", "protein_names_refseq": "ESCRT-II complex subunit VPS25; vacuolar protein-sorting-associated protein 25 isoform 1; vacuolar protein-sorting-associated protein 25", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305)", "pathway": " (mmu:28084); (R-MMU-917729)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;25373905;25428506;26495903;30779550;34428180", "class_list": "", "function": "Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Vps25(ENU/ENU) mutants survive until late gestation. Their limbs display FGF signaling enhancement and consequent hyperactivation of the FGF-SHH feedback loop causing polydactyly., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A4J9;A2A4K1;Q3UBT0;Q9D167", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0000814 ESCRT II complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0006351 DNA-templated transcription;GO:0016236 macroautophagy;GO:0007175 negative regulation of epidermal growth factor-activated receptor activity;GO:0071985 multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CQ80-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1G2-1", "uniprot_id": [ { "id": "CMBL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1G2", "type": "external" } ], "mass": 27902.0, "length": 245, "protein_name": "Carboxymethylenebutenolidase homolog", "gene_name": "Cmbl", "organism": "Mouse", "refseq_name": "carboxymethylenebutenolidase homolog", "refseq_ac": [ { "id": "NP_853619", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_853619", "type": "external" } ], "gene_names_uniprotkb": "Cmbl", "gene_names_refseq": "2310016A09Rik; Cmbl", "protein_names_uniprotkb": "Carboxymethylenebutenolidase homolog; 3.1.-.-", "protein_names_refseq": "carboxymethylenebutenolidase homolog; carboxymethylenebutenolidase-like (Pseudomonas)", "tax_id": 10090, "disease": "", "pathway": " (mmu:69574); (R-MMU-211945)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;37453647;37507081;39927985", "class_list": "", "function": "Cysteine hydrolase whose endogenous substrates and physiological function are unknown. In vitro, catalyzes the hydrolytic activation of several ester-based prodrugs, by cleaving the dioxolone ring to yield their respective active metabolites, diacetyl and CO2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1N1", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R1G2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAJ4-1", "uniprot_id": [ { "id": "WDR83_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAJ4", "type": "external" } ], "mass": 34444.0, "length": 315, "protein_name": "WD repeat domain-containing protein 83", "gene_name": "Wdr83", "organism": "Mouse", "refseq_name": "WD repeat domain-containing protein 83", "refseq_ac": [ { "id": "NP_080675", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080675", "type": "external" } ], "gene_names_uniprotkb": "Wdr83; Morg1", "gene_names_refseq": "1500041N16Rik; Morg1; Wdr83", "protein_names_uniprotkb": "WD repeat domain-containing protein 83; MAPK organizer 1; Mitogen-activated protein kinase organizer 1", "protein_names_refseq": "MAPK cascade scaffold protein; MAPK organizer 1; WD repeat domain-containing protein 83; mitogen-activated protein kinase organizer 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67836); (R-MMU-5674135)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "15118098;19726548;21750661;22555025;22982595;29402223;31219806;37509073;38450633", "class_list": "", "function": "MORG1 heterozygosity protects against histological renal damage and shows anti-inflammatory effects in a murine endotoxemia model. Publication Status: Online-Only, [RefSeq, PubMed]; Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing. Participates in tight junction development by regulating apico-basal polarity, a key step in tissue development and organization. Mechanistically, regulates the translocation of PAR6-aPKC from the cytoplasm to the apical surface by acting as an adapter between PARD6B AND CRB3. Also acts as a negative regulator of mTORC1 under nutrient-rich conditions by binding to the active Rag GTPases to inhibit mTORC1 localization to the lysosome and phosphorylation of downstream targets. This facilitates constitutive basal autophagy during nutrient availability (By similarity)., [UniProtKB, PubMed, UniProtKB]; Morg1 may be a novel therapeutic target to limit renal injury after ischemia-reperfusion, [RefSeq, PubMed]; Targeted Disruption of the MORG1 Gene in Mice Causes Embryonic Resorption in Early Phase of Development. Publication Status: Online-Only, [RefSeq, PubMed]; The major finding of this study is that Morg1+/- mice are partially protected from cerebral ischemia and reperfusion injury in comparison to the WT (Morg1+/+) animals, [RefSeq, PubMed]; This study shows for the first time in various renal cells that ANG II modulates Morg1 expression and HIF-1alpha transcriptional activity via cell type-specific mechanisms, demonstrating a novel mechanism by which ANG II may contribute to renal disease., [RefSeq, PubMed]; WDR83/MORG1 inhibits RRAG GTPase-MTORC1 signaling to facilitate basal autophagy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q505C2;Q8VEB7;Q99JX9;Q9D235", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0005764 lysosome;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0000375 RNA splicing, via transesterification reactions;GO:0032496 response to lipopolysaccharide;GO:0001666 response to hypoxia;GO:0009611 response to wounding;GO:0001843 neural tube closure", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9DAJ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true } ]