[ { "uniprot_canonical_ac": "Q5QD11-1", "uniprot_id": [ { "id": "TAA7B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5QD11", "type": "external" } ], "mass": 40231.0, "length": 358, "protein_name": "Trace amine-associated receptor 7b", "gene_name": "Taar7b", "organism": "Mouse", "refseq_name": "trace amine-associated receptor 7b", "refseq_ac": [ { "id": "NP_001010827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010827", "type": "external" } ], "gene_names_uniprotkb": "Taar7b; Gm698", "gene_names_refseq": "Gm698; Taar7b; taR-7b", "protein_names_uniprotkb": "Trace amine-associated receptor 7b; TaR-7b; Trace amine receptor 7b; mTaar7b", "protein_names_refseq": "mTaar7b; trace amine-associated receptor 7b", "tax_id": 10090, "disease": "", "pathway": " (mmu:209517)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15718104;16878137;22545963;23624375", "class_list": "", "function": "Olfactory receptor specific for N,N-dimethylalkylamines trace amines, such as N,N-dimethylcyclohexylamine (PubMed:22545963). Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors (PubMed:22545963). Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS) (Probable)., [UniProtKB, PubMed]; Previous studies reported TAAR expression in brain. This paper found TAAR expression only in olfactory epithelial cells and that each TAAR detects a unique set of amine ligands. TAARs seem to function as a family of chemosensory receptors for amines., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5QD11-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5QD12-1", "uniprot_id": [ { "id": "TAA7A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5QD12", "type": "external" } ], "mass": 40368.0, "length": 358, "protein_name": "Trace amine-associated receptor 7a", "gene_name": "Taar7a", "organism": "Mouse", "refseq_name": "trace amine-associated receptor 7a", "refseq_ac": [ { "id": "NP_001010829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010829", "type": "external" } ], "gene_names_uniprotkb": "Taar7a; Gm229", "gene_names_refseq": "Gm229; Taar7a; taR-7a", "protein_names_uniprotkb": "Trace amine-associated receptor 7a; TaR-7a; Trace amine receptor 7a; mTaar7a", "protein_names_refseq": "mTaar7a; trace amine-associated receptor 7a", "tax_id": 10090, "disease": "", "pathway": " (mmu:215856)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15718104;16878137;23624375", "class_list": "", "function": "Olfactory receptor specific for N,N-dimethylalkylamines trace amines. Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors. Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS)., [UniProtKB, UniProtKB]; Previous studies reported TAAR expression in brain. This paper found TAAR expression only in olfactory epithelial cells and that each TAAR detects a unique set of amine ligands. TAARs seem to function as a family of chemosensory receptors for amines., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5QD12-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62395-1", "uniprot_id": [ { "id": "TFF3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62395", "type": "external" } ], "mass": 8808.0, "length": 81, "protein_name": "Trefoil factor 3", "gene_name": "Tff3", "organism": "Mouse", "refseq_name": "trefoil factor 3 precursor", "refseq_ac": [ { "id": "NP_035705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035705", "type": "external" } ], "gene_names_uniprotkb": "Tff3; Itf", "gene_names_refseq": "ITF; Tff3; mITF", "protein_names_uniprotkb": "Trefoil factor 3; Intestinal trefoil factor; mITF", "protein_names_refseq": "intestinal trefoil factor; trefoil factor 3 precursor", "tax_id": 10090, "disease": "pre-malignant neoplasm (Disease Ontology:DOID:0060071); prostate cancer (Disease Ontology:DOID:10283); colon cancer (Disease Ontology:DOID:219)", "pathway": " (mmu:21786)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11290420;37108475;38003531;7575467;7741746;8666281;8824194", "class_list": "", "function": "Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen)., [UniProtKB, PubMed]; Tff3 Deficiency Differentially Affects the Morphology of Male and Female Intestines in a Long-Term High-Fat-Diet-Fed Mouse Model. Publication Status: Online-Only, [RefSeq, PubMed]; Tff3[-/-] Knock-Out Mice with Altered Lipid Metabolism Exhibit a Lower Level of Inflammation following the Dietary Intake of Sodium Chloride for One Week. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64352", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0010906 regulation of glucose metabolic process;GO:0030277 maintenance of gastrointestinal epithelium", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62395-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6X6Z7-1", "uniprot_id": [ { "id": "TEKT3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6X6Z7", "type": "external" } ], "mass": 56673.0, "length": 490, "protein_name": "Tektin-3", "gene_name": "Tekt3", "organism": "Mouse", "refseq_name": "tektin-3", "refseq_ac": [ { "id": "NP_081936", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081936", "type": "external" } ], "gene_names_uniprotkb": "Tekt3", "gene_names_refseq": "4933407G07Rik; Tekt3", "protein_names_uniprotkb": "Tektin-3", "protein_names_refseq": "tektin-3", "tax_id": 10090, "disease": "spermatogenic failure 81 (Disease Ontology:DOID:0070580)", "pathway": " (mmu:71062)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14735490;18951373;30084848;36206347;37295417;37865089;37989994", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme (PubMed:37295417, PubMed:37865089, PubMed:37989994). Forms filamentous polymers in the walls of ciliary and flagellar microtubules (PubMed:37295417). Required for normal sperm mobility (PubMed:18951373)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Study reports the functional characterization of tektin 3 (TEKT3) in spermatozoa, flagellar motility, and male reproductive physiology, [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 4, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005737 cytoplasm;GO:0015630 microtubule cytoskeleton;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0060378 regulation of brood size;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6X6Z7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TM95-1", "uniprot_id": [ { "id": "TIGD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TM95", "type": "external" } ], "mass": 52223.0, "length": 470, "protein_name": "Tigger transposable element-derived protein 3", "gene_name": "Tigd3", "organism": "Mouse", "refseq_name": "tigger transposable element-derived protein 3", "refseq_ac": [ { "id": "NP_941036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_941036", "type": "external" } ], "gene_names_uniprotkb": "Tigd3", "gene_names_refseq": "Tigd3", "protein_names_uniprotkb": "Tigger transposable element-derived protein 3", "protein_names_refseq": "tigger transposable element derived 3 homolog; tigger transposable element-derived protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:332359)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7TM95-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TMM9-1", "uniprot_id": [ { "id": "TBB2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TMM9", "type": "external" } ], "mass": 49907.0, "length": 445, "protein_name": "Tubulin beta-2A chain", "gene_name": "Tubb2a", "organism": "Mouse", "refseq_name": "tubulin beta-2A chain", "refseq_ac": [ { "id": "NP_033476", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033476", "type": "external" } ], "gene_names_uniprotkb": "Tubb2a; Tubb2", "gene_names_refseq": "M(beta)2; Tubb2a; Tubb2", "protein_names_uniprotkb": "Tubulin beta-2A chain", "protein_names_refseq": "tubulin beta-2A chain; tubulin, beta polypeptide", "tax_id": 10090, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome (Disease Ontology:DOID:0050997); ptosis (Disease Ontology:DOID:0060260); complex cortical dysplasia with other brain malformations 7 (Disease Ontology:DOID:0090132); complex cortical dysplasia with other brain malformations 5 (Disease Ontology:DOID:0090135); tubulinopathy (Disease Ontology:DOID:0112227); facial paralysis (Disease Ontology:DOID:13934)", "pathway": " (mmu:22151); (R-MMU-190840); (R-MMU-2132295); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-3371497); (R-MMU-380320); (R-MMU-437239); (R-MMU-5610787); (R-MMU-5620920); (R-MMU-5620924); (R-MMU-5626467); (R-MMU-5663220); (R-MMU-6807878); (R-MMU-6811434); (R-MMU-6811436); (R-MMU-68877); (R-MMU-8852276); (R-MMU-8955332); (R-MMU-9646399); (R-MMU-9648025); (R-MMU-9668328); (R-MMU-983189); (R-MMU-9833482)", "pathway_count": 24, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;15890843;19524510;19737534;22645316;23897886;31386652;33300544;33414192;33725478;34418053;34428180;35984892;37453647;40684658", "class_list": "", "function": "Study shows that loss of Tubb2a or Tubb2b does not impair survival but does lead to relatively mild cortical malformation phenotypes. In contrast, loss of Tuba1a is perinatal lethal and leads to significant forebrain dysmorphology. The ability of the mouse to survive in the absence of some tubulin genes known to cause disease in humans suggests future intervention strategies for these devastating tubulinopathy diseases. Publication Status: Online-Only, [RefSeq, PubMed]; Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 6, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton;GO:0045171 intercellular bridge", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0001764 neuron migration;GO:0021987 cerebral cortex development;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q7TMM9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80W35-1", "uniprot_id": [ { "id": "TM202_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80W35", "type": "external" } ], "mass": 31551.0, "length": 275, "protein_name": "Transmembrane protein 202", "gene_name": "Tmem202", "organism": "Mouse", "refseq_name": "transmembrane protein 202 isoform 1", "refseq_ac": [ { "id": "NP_848475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848475", "type": "external" } ], "gene_names_uniprotkb": "Tmem202", "gene_names_refseq": "4930425N13Rik; Tmem202", "protein_names_uniprotkb": "Transmembrane protein 202", "protein_names_refseq": "transmembrane protein 202 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:73893)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q80W35-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGV3-1", "uniprot_id": [ { "id": "TACD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGV3", "type": "external" } ], "mass": 35574.0, "length": 317, "protein_name": "Tumor-associated calcium signal transducer 2", "gene_name": "Tacstd2", "organism": "Mouse", "refseq_name": "tumor-associated calcium signal transducer 2 precursor", "refseq_ac": [ { "id": "NP_064431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064431", "type": "external" } ], "gene_names_uniprotkb": "Tacstd2; Trop2", "gene_names_refseq": "EGP-1; GA733-1; Ly97; TROP2; Tacstd2", "protein_names_uniprotkb": "Tumor-associated calcium signal transducer 2; Cell surface glycoprotein Trop-2", "protein_names_refseq": "cell surface glycoprotein Trop-2; lymphocyte antigen 97; tumor-associated calcium signal transducer 2 precursor; tunor-associated calcium signal transducer 2", "tax_id": 10090, "disease": "gelatinous drop-like corneal dystrophy (Disease Ontology:DOID:0060449); corneal dystrophy (Disease Ontology:DOID:2566)", "pathway": " (mmu:56753)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19088204;20858281;28011936;9462726", "class_list": "", "function": "May function as a growth factor receptor., [UniProtKB]; Study also provides the first indication of a molecular signaling pathway activated by Trop2 which has important implications for cancer cell growth and survival. Publication Status: Online-Only, [RefSeq, PubMed]; Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O55130", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0010633 negative regulation of epithelial cell migration;GO:0050678 regulation of epithelial cell proliferation;GO:1900028 negative regulation of ruffle assembly;GO:1900025 negative regulation of substrate adhesion-dependent cell spreading;GO:2000146 negative regulation of cell motility", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BGV3-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH24-1", "uniprot_id": [ { "id": "TM9S4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH24", "type": "external" } ], "mass": 74693.0, "length": 643, "protein_name": "Transmembrane 9 superfamily member 4", "gene_name": "Tm9sf4", "organism": "Mouse", "refseq_name": "transmembrane 9 superfamily member 4 precursor", "refseq_ac": [ { "id": "NP_598608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598608", "type": "external" } ], "gene_names_uniprotkb": "Tm9sf4; Kiaa0255", "gene_names_refseq": "B930079E06; Tm9sf4; mKIAA0255", "protein_names_uniprotkb": "Transmembrane 9 superfamily member 4", "protein_names_refseq": "transmembrane 9 superfamily member 4 precursor; transmembrane 9 superfamily protein member 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:99237)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;26495903;30084848;31219806;34428180;34774100", "class_list": "", "function": "Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface., [UniProtKB, UniProtKB]; TM9SF4 is a novel regulator in lineage commitment of bone marrow mesenchymal stem cells to either osteoblasts or adipocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q2TBF8;Q3TB27;Q8BU80;Q8BXB4;Q8CHH4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:2000010 positive regulation of protein localization to cell surface;GO:0001666 response to hypoxia;GO:0006909 phagocytosis;GO:0072657 protein localization to membrane", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BH24-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHW5-1", "uniprot_id": [ { "id": "T255A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHW5", "type": "external" } ], "mass": 38633.0, "length": 351, "protein_name": "Transmembrane protein 255A", "gene_name": "Tmem255a", "organism": "Mouse", "refseq_name": "transmembrane protein 255A isoform 2", "refseq_ac": [ { "id": "NP_001276656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276656", "type": "external" } ], "gene_names_uniprotkb": "Tmem255a; Fam70a", "gene_names_refseq": "4933417N17; 6430550H21Rik; Fam70a; Tmem255a", "protein_names_uniprotkb": "Transmembrane protein 255A; Protein FAM70A", "protein_names_refseq": "family with sequence similarity 70, member A; protein FAM70A; transmembrane protein 255A isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:245386)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17660561;32391621;34428180;35820727", "class_list": "", "function": "Fam70A regulates meiosis and quality of mouse oocytes through both canonical and non-canonical Wnt5a signalling pathways., [RefSeq, PubMed]; Transcripts highly enriched in ovary; gene identified as candidate female fertility factor., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P5C9;Q8BHV8;Q8BHZ6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BHW5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BP07-1", "uniprot_id": [ { "id": "TM220_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BP07", "type": "external" } ], "mass": 18324.0, "length": 167, "protein_name": "Transmembrane protein 220", "gene_name": "Tmem220", "organism": "Mouse", "refseq_name": "transmembrane protein 220 isoform 2", "refseq_ac": [ { "id": "NP_001277971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277971", "type": "external" } ], "gene_names_uniprotkb": "Tmem220", "gene_names_refseq": "Tmem220", "protein_names_uniprotkb": "Transmembrane protein 220", "protein_names_refseq": "transmembrane protein 220 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:338369)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2TB06;Q8C936", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BP07-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BUY5-1", "uniprot_id": [ { "id": "TIDC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BUY5", "type": "external" } ], "mass": 31791.0, "length": 285, "protein_name": "Complex I assembly factor TIMMDC1, mitochondrial", "gene_name": "Timmdc1", "organism": "Mouse", "refseq_name": "complex I assembly factor TIMMDC1, mitochondrial", "refseq_ac": [ { "id": "NP_077235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077235", "type": "external" } ], "gene_names_uniprotkb": "Timmdc1", "gene_names_refseq": "2810021C21Rik; 4930455C21Rik; Timmdc1", "protein_names_uniprotkb": "Complex I assembly factor TIMMDC1, mitochondrial; TIMM domain containing protein 1; Translocase of inner mitochondrial membrane domain-containing protein 1", "protein_names_refseq": "TIMM domain containing-protein 1; complex I assembly factor TIMMDC1, mitochondrial; translocase of inner mitochondrial membrane domain-containing protein 1; transmembrane protein C3orf1 homolog", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 31 (Disease Ontology:DOID:0112071)", "pathway": " (mmu:76916); (R-MMU-6799198)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "36288343", "class_list": "", "function": "Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99LS9;Q9CSI1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BUY5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C176-1", "uniprot_id": [ { "id": "TAF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C176", "type": "external" } ], "mass": 126997.0, "length": 1104, "protein_name": "Transcription initiation factor TFIID subunit 2", "gene_name": "Taf2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Taf2", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 2; TAF(II)150; TAFII-150; TAFII150; TBP-associated factor 150 kDa; Transcription initiation factor TFIID 150 kDa subunit", "protein_names_refseq": "", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 40 (Disease Ontology:DOID:0081205)", "pathway": " (R-MMU-674695); (R-MMU-6804756); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-76042)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF2 forms a promoter DNA binding subcomplex of TFIID, together with TAF7 and TAF1., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKQ7", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0033276 transcription factor TFTC complex;GO:0005634 nucleus;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0000086 G2/M transition of mitotic cell cycle;GO:0045893 positive regulation of DNA-templated transcription;GO:0006367 transcription initiation at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C176-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CCM6-2", "uniprot_id": [ { "id": "TIM21_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CCM6", "type": "external" } ], "mass": 27911.0, "length": 244, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim21", "gene_name": "Timm21", "organism": "Mouse", "refseq_name": "mitochondrial import inner membrane translocase subunit Tim21", "refseq_ac": [ { "id": "NP_080245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080245", "type": "external" } ], "gene_names_uniprotkb": "Timm21; Tim21", "gene_names_refseq": "1700034H14Rik; 2700002I20Rik; Timm21", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim21; TIM21-like protein, mitochondrial", "protein_names_refseq": "TIM21-like protein, mitochondrial; mitochondrial import inner membrane translocase subunit Tim21; tranlocase of inner mitochondrial membrane 21", "tax_id": 10090, "disease": "", "pathway": " (mmu:67105); (R-MMU-9864848)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16075062", "class_list": "", "function": "Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3THX0;Q8CE44;Q9CYU8;Q9CZS4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005744 TIM23 mitochondrial import inner membrane translocase complex", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CCM6-2", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGF7-1", "uniprot_id": [ { "id": "TCRG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CGF7", "type": "external" } ], "mass": 123788.0, "length": 1100, "protein_name": "Transcription elongation regulator 1", "gene_name": "Tcerg1", "organism": "Mouse", "refseq_name": "transcription elongation regulator 1 isoform 1", "refseq_ac": [ { "id": "NP_001034563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034563", "type": "external" } ], "gene_names_uniprotkb": "Tcerg1; Taf2s", "gene_names_refseq": "2410022J09Rik; 2900090C16Rik; CA150b; FBP23; FBP28; Taf2s; Tcerg1; ca150; p144", "protein_names_uniprotkb": "Transcription elongation regulator 1; FBP 28; Formin-binding protein 28; TATA box-binding protein-associated factor 2S; Transcription factor CA150; p144", "protein_names_refseq": "TATA box binding protein (TBP)-associated factor, RNA polymerase II, S, 150kD; TATA box-binding protein-associated factor 2S; coactivator of 150 kD; formin-binding protein 28; transcription elongation regulator 1 isoform 1; transcription factor CA150b", "tax_id": 10090, "disease": "", "pathway": " (mmu:56070); (R-MMU-72163); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10578054;10802733;15485897;17355961;21365688;21750661;24129315;25605945;33300544;34428180;34887587;39627609;40997131;8605874", "class_list": "", "function": "The study examines the order of formation of two beta-hairpins, the folding mechanism of each individual beta-hairpin, and transition state ensemble of formin-binding protein 28, FBP28 WW domain., [RefSeq, PubMed]; Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q61051;Q8C490;Q8CHT8;Q9R0R5", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity;GO:0070064 proline-rich region binding;GO:0070063 RNA polymerase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8CGF7-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K0Z7-1", "uniprot_id": [ { "id": "TACO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K0Z7", "type": "external" } ], "mass": 32314.0, "length": 294, "protein_name": "Translational activator of cytochrome c oxidase 1", "gene_name": "Taco1", "organism": "Mouse", "refseq_name": "translational activator of cytochrome c oxidase 1", "refseq_ac": [ { "id": "NP_081622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081622", "type": "external" } ], "gene_names_uniprotkb": "Taco1; Ccdc44", "gene_names_refseq": "2310066I18Rik; Ccdc44; Taco1", "protein_names_uniprotkb": "Translational activator of cytochrome c oxidase 1; Coiled-coil domain-containing protein 44; Translational activator of mitochondrially-encoded cytochrome c oxidase 1", "protein_names_refseq": "coiled-coil domain-containing protein 44; translational activator of cytochrome c oxidase 1; translational activator of mitochondrially-encoded cytochrome c oxidase 1", "tax_id": 10090, "disease": "mitochondrial complex IV deficiency nuclear type 8 (Disease Ontology:DOID:0070495)", "pathway": " (mmu:70207)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "23576753;25428506;27319982;30084848;34105348;34428180;37507081", "class_list": "", "function": "Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1., [UniProtKB]; The Taco1 mutant mice develop a late-onset visual impairment, motor dysfunction and cardiac hypertrophy and thus provide a useful model for future treatment trials for mitochondrial disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AR86;Q3TI86;Q3USS8;Q9CV09", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0019843 rRNA binding;GO:0097177 mitochondrial ribosome binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0061743 motor learning;GO:0070129 regulation of mitochondrial translation;GO:1904959 regulation of cytochrome-c oxidase activity;GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0070131 positive regulation of mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8K0Z7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1H7-1", "uniprot_id": [ { "id": "T11L2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1H7", "type": "external" } ], "mass": 57889.0, "length": 517, "protein_name": "T-complex protein 11-like protein 2", "gene_name": "Tcp11l2", "organism": "Mouse", "refseq_name": "T-complex protein 11-like protein 2", "refseq_ac": [ { "id": "NP_666120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666120", "type": "external" } ], "gene_names_uniprotkb": "Tcp11l2", "gene_names_refseq": "E430026E19Rik; Tcp11l2", "protein_names_uniprotkb": "T-complex protein 11-like protein 2", "protein_names_refseq": "T-complex protein 11-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:216198)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19224205;20173027;34428180", "class_list": "", "function": "Promotes the migration of muscle-derived satellite cells (MDSCs) during differentiation throught interaction with FMNL2 and therefore may participate in microfilament assembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2D5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0016607 nuclear speck", "go_biological_process": "GO:0007165 signal transduction;GO:0014812 muscle cell migration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K1H7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0A0-1", "uniprot_id": [ { "id": "T2FB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0A0", "type": "external" } ], "mass": 28381.0, "length": 249, "protein_name": "General transcription factor IIF subunit 2", "gene_name": "Gtf2f2", "organism": "Mouse", "refseq_name": "general transcription factor IIF subunit 2 isoform 1", "refseq_ac": [ { "id": "NP_081092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081092", "type": "external" } ], "gene_names_uniprotkb": "Gtf2f2", "gene_names_refseq": "1110031C13Rik; Gtf2f2; TFIIF-beta", "protein_names_uniprotkb": "General transcription factor IIF subunit 2; TFIIF-beta; Transcription initiation factor IIF subunit beta", "protein_names_refseq": "ATP-dependent helicase GTF2F2; general transcription factor IIF subunit 2 isoform 1; general transcription factor IIF subunit 2; transcription initiation factor IIF subunit beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:68705); (R-MMU-112382); (R-MMU-113418); (R-MMU-674695); (R-MMU-6796648); (R-MMU-6803529); (R-MMU-6807505); (R-MMU-72086); (R-MMU-72163); (R-MMU-72165); (R-MMU-72203); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-75955); (R-MMU-76042); (R-MMU-77075); (R-MMU-9018519); (R-MMU-9770562)", "pathway_count": 19, "publication_count": 5, "publication_id_list": "14612417;23806337;32782141;34428180;34678516", "class_list": "", "function": "TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0015630 microtubule cytoskeleton;GO:0005675 transcription factor TFIIH holo complex;GO:0005674 transcription factor TFIIF complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R0A0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDR7-1", "uniprot_id": [ { "id": "TGDS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDR7", "type": "external" } ], "mass": 40570.0, "length": 355, "protein_name": "UDP-D-glucose 4,6-dehydratase", "gene_name": "Tgds", "organism": "Mouse", "refseq_name": "UDP-D-glucose 4,6-dehydratase", "refseq_ac": [ { "id": "NP_083854", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083854", "type": "external" } ], "gene_names_uniprotkb": "Tgds", "gene_names_refseq": "2610017J16Rik; 2610025M23Rik; Tgds", "protein_names_uniprotkb": "UDP-D-glucose 4,6-dehydratase; 4.2.1.76; dTDP-D-glucose 4,6-dehydratase", "protein_names_refseq": "UDP-D-glucose 4,6-dehydratase; dTDP-D-glucose 4,6-dehydratase", "tax_id": 10090, "disease": "Catel Manzke syndrome (Disease Ontology:DOID:0081122)", "pathway": " (mmu:76355)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;21952136;25428507;25605945;31219806;34428180;37828378;40836090", "class_list": "glycogene", "function": "UDP-glucose 4,6-dehydratase that converts UDP-glucose into UDP-4-keto-6-deoxyglucose, and which is required for glycosaminoglycan biosynthesis and skeletal development (PubMed:40836090). UDP-4-keto-6-deoxyglucose is a mimic of the reaction intermediate of UXS1 and acts as an enzyme-rescue metabolite to promote the completion of UXS1 catalytic cycle when NAD(+) levels are low (PubMed:40836090). Under low NAD(+) conditions, UXS1 forms an inactive UDP-4-ketoxylose intermediate bound to NADH, impairing the synthesis of specific glycans that are essential for skeletal development (PubMed:40836090). UDP-4-keto-6-deoxyglucose is used by the inactive NADH-bound UXS1 to produce UDP-6-deoxyglucose and NAD(+) within the catalytic pocket of UXS1, regenerating the essential cofactor NAD(+) (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4A6", "ec_number_list": [ { "id": "4.2.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.76", "type": "external" } ], "go_molecular_function": "GO:0008460 dTDP-glucose 4,6-dehydratase activity;GO:0050377 UDP-glucose 4,6-dehydratase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006024 glycosaminoglycan biosynthetic process;GO:0009225 nucleotide-sugar metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VDR7-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q922F4-1", "uniprot_id": [ { "id": "TBB6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q922F4", "type": "external" } ], "mass": 50090.0, "length": 447, "protein_name": "Tubulin beta-6 chain", "gene_name": "Tubb6", "organism": "Mouse", "refseq_name": "tubulin beta-6 chain", "refseq_ac": [ { "id": "NP_080749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080749", "type": "external" } ], "gene_names_uniprotkb": "Tubb6", "gene_names_refseq": "2310057H16Rik; Tubb6", "protein_names_uniprotkb": "Tubulin beta-6 chain", "protein_names_refseq": "tubulin beta-6 chain", "tax_id": 10090, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome (Disease Ontology:DOID:0050997); ptosis (Disease Ontology:DOID:0060260); complex cortical dysplasia with other brain malformations 7 (Disease Ontology:DOID:0090132); tubulinopathy (Disease Ontology:DOID:0112227); facial paralysis (Disease Ontology:DOID:13934)", "pathway": " (mmu:67951); (R-MMU-190840); (R-MMU-2132295); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-3371497); (R-MMU-380320); (R-MMU-437239); (R-MMU-5610787); (R-MMU-5620920); (R-MMU-5620924); (R-MMU-5626467); (R-MMU-5663220); (R-MMU-6807878); (R-MMU-6811434); (R-MMU-6811436); (R-MMU-68877); (R-MMU-8852276); (R-MMU-8955332); (R-MMU-9646399); (R-MMU-9648025); (R-MMU-9668328); (R-MMU-983189); (R-MMU-9833482)", "pathway_count": 24, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;15890843;18553364;19524510;20665223;22645316;23897886;25605945;32265273;33300544;33414192;33725478;34428180;35984892", "class_list": "", "function": "Primary myeloid cell proteomics and transcriptomics: importance of beta-tubulin isotypes for osteoclast function. Publication Status: Online-Only, [RefSeq, PubMed]; The results provide the first evidence that a specific isoform of beta-tubulin is required for mitosis.[beta5 tubulin], [RefSeq, PubMed]; Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 5, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton;GO:0045171 intercellular bridge;GO:0072686 mitotic spindle", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q922F4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99J36-1", "uniprot_id": [ { "id": "THUM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99J36", "type": "external" } ], "mass": 38885.0, "length": 350, "protein_name": "THUMP domain-containing protein 1", "gene_name": "Thumpd1", "organism": "Mouse", "refseq_name": "THUMP domain-containing protein 1", "refseq_ac": [ { "id": "NP_663560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663560", "type": "external" } ], "gene_names_uniprotkb": "Thumpd1", "gene_names_refseq": "6330575P11Rik; Thumpd1", "protein_names_uniprotkb": "THUMP domain-containing protein 1", "protein_names_refseq": "THUMP domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:233802)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17242355;18630941;19131326;21183079;30779550;34428180", "class_list": "", "function": "Functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation modifying cytidine to N4-acetylcytidine (ac4C)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U6Y3", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "", "go_biological_process": "GO:0006400 tRNA modification", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99J36-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LQ7-1", "uniprot_id": [ { "id": "PEDS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LQ7", "type": "external" } ], "mass": 31134.0, "length": 271, "protein_name": "Plasmanylethanolamine desaturase 1", "gene_name": "Peds1", "organism": "Mouse", "refseq_name": "plasmanylethanolamine desaturase 1", "refseq_ac": [ { "id": "NP_663513", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663513", "type": "external" } ], "gene_names_uniprotkb": "Peds1; Peds; Tmem189", "gene_names_refseq": "Kua; Peds1; Tmem189", "protein_names_uniprotkb": "Plasmanylethanolamine desaturase 1; 1.14.19.77; Transmembrane protein 189", "protein_names_refseq": "plasmanylethanolamine desaturase 1; plasmanylethanolamine desaturase; transmembrane protein 189", "tax_id": 10090, "disease": "", "pathway": " (mmu:407243)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "32209662;34428180;35347434", "class_list": "", "function": "Essential role of a conserved aspartate for the enzymatic activity of plasmanylethanolamine desaturase. Publication Status: Online-Only, [RefSeq, PubMed]; Plasmanylethanolamine desaturase involved in plasmalogen biogenesis in the endoplasmic reticulum membrane. Plasmalogens are glycerophospholipids with a hydrocarbon chain linked by a vinyl ether bond at the glycerol sn-1 position, and are involved in antioxidative and signaling mechanisms., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.19.77", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.77", "type": "external" } ], "go_molecular_function": "GO:0050207 plasmanylethanolamine desaturase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0008611 ether lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99LQ7-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR76-1", "uniprot_id": [ { "id": "TM186_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR76", "type": "external" } ], "mass": 24632.0, "length": 216, "protein_name": "Transmembrane protein 186", "gene_name": "Tmem186", "organism": "Mouse", "refseq_name": "transmembrane protein 186 isoform 1", "refseq_ac": [ { "id": "NP_079984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079984", "type": "external" } ], "gene_names_uniprotkb": "Tmem186", "gene_names_refseq": "2810440M13Rik; 4432406C05Rik; Tmem186", "protein_names_uniprotkb": "Transmembrane protein 186", "protein_names_refseq": "transmembrane protein 186 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66690); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "25428506;30084848;30779550;34428180", "class_list": "", "function": "As part of the MCIA complex, required for efficient assembly of the mitochondrial complex I., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHA7;Q8BHT1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0160295 mitochondrial complex I intermediate assembly complex", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CR76-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0D5-1", "uniprot_id": [ { "id": "T2EA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0D5", "type": "external" } ], "mass": 49593.0, "length": 440, "protein_name": "General transcription factor IIE subunit 1", "gene_name": "Gtf2e1", "organism": "Mouse", "refseq_name": "general transcription factor IIE subunit 1", "refseq_ac": [ { "id": "NP_083088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083088", "type": "external" } ], "gene_names_uniprotkb": "Gtf2e1", "gene_names_refseq": "2610024P03Rik; 56kDa; FE; Gtf2e1; TFIIE-A", "protein_names_uniprotkb": "General transcription factor IIE subunit 1; General transcription factor IIE 56 kDa subunit; TFIIE-alpha; Transcription initiation factor IIE subunit alpha", "protein_names_refseq": "TFIIE-alpha; general transcription factor II E, polypeptide 1 (alpha subunit, 56kDa); general transcription factor IIE 56 kDa subunit; general transcription factor IIE subunit 1; general transcription factor IIE, polypeptide 1 (alpha subunit, 56kDa); transcription initiation factor IIE subunit alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:74197); (R-MMU-674695); (R-MMU-6807505); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-76042)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q544T0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005673 transcription factor TFIIE complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D0D5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D5W8-1", "uniprot_id": [ { "id": "TEX47_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D5W8", "type": "external" } ], "mass": 29423.0, "length": 253, "protein_name": "Testis-expressed protein 47", "gene_name": "Tex47", "organism": "Mouse", "refseq_name": "testis-expressed protein 47", "refseq_ac": [ { "id": "NP_081879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081879", "type": "external" } ], "gene_names_uniprotkb": "Tex47", "gene_names_refseq": "4921511H03Rik; Tex47", "protein_names_uniprotkb": "Testis-expressed protein 47", "protein_names_refseq": "testis-expressed protein 47; uncharacterized protein C7orf62 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:70920)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D5W8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D6F9-1", "uniprot_id": [ { "id": "TBB4A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D6F9", "type": "external" } ], "mass": 49586.0, "length": 444, "protein_name": "Tubulin beta-4A chain", "gene_name": "Tubb4a", "organism": "Mouse", "refseq_name": "tubulin beta-4A chain", "refseq_ac": [ { "id": "NP_033477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033477", "type": "external" } ], "gene_names_uniprotkb": "Tubb4a; Tubb4", "gene_names_refseq": "M(beta)4; Tubb4a; Tubb4; Tubb", "protein_names_uniprotkb": "Tubulin beta-4A chain; Tubulin beta-4 chain", "protein_names_refseq": "tubulin beta-4 chain; tubulin beta-4A chain", "tax_id": 10090, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome (Disease Ontology:DOID:0050997); ptosis (Disease Ontology:DOID:0060260); hypomyelinating leukodystrophy 6 (Disease Ontology:DOID:0060798); torsion dystonia 4 (Disease Ontology:DOID:0090041); complex cortical dysplasia with other brain malformations 7 (Disease Ontology:DOID:0090132); tubulinopathy (Disease Ontology:DOID:0112227); facial paralysis (Disease Ontology:DOID:13934); demyelinating disease (Disease Ontology:DOID:3213)", "pathway": " (mmu:22153); (R-MMU-190840); (R-MMU-2132295); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-2565942); (R-MMU-3371497); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-437239); (R-MMU-5610787); (R-MMU-5620912); (R-MMU-5620920); (R-MMU-5620924); (R-MMU-5626467); (R-MMU-5663220); (R-MMU-6807878); (R-MMU-6811434); (R-MMU-6811436); (R-MMU-68877); (R-MMU-8852276); (R-MMU-8854518); (R-MMU-8955332); (R-MMU-9646399); (R-MMU-9648025); (R-MMU-9668328); (R-MMU-983189); (R-MMU-9833482)", "pathway_count": 30, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;15890843;19524510;22645316;23897886;33300544;33414192;33725478;34260942;34428180;3839797;40684658", "class_list": "glycogene", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 26, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q62364;Q80Y54", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0033269 internode region of axon;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005929 cilium", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization;GO:0030030 cell projection organization;GO:0031115 negative regulation of microtubule polymerization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9D6F9-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8U2-1", "uniprot_id": [ { "id": "TM41A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8U2", "type": "external" } ], "mass": 29370.0, "length": 264, "protein_name": "Transmembrane protein 41A", "gene_name": "Tmem41a", "organism": "Mouse", "refseq_name": "transmembrane protein 41A precursor", "refseq_ac": [ { "id": "NP_079969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079969", "type": "external" } ], "gene_names_uniprotkb": "Tmem41a", "gene_names_refseq": "2900010K02Rik; 5730578N08Rik; Tmem41a", "protein_names_uniprotkb": "Transmembrane protein 41A", "protein_names_refseq": "transmembrane protein 41A precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:66664)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;25428506;30015937;30084848;31219806;34428180", "class_list": "", "function": "The present study demonstrated a reduction in TMEM41A expression levels in a pair of GC cell lines, and revealed that high TMEM41A expression levels may promote GC-associated metastasis, which may be mediated by the downregulation of E-cadherin expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D8U2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQH4-1", "uniprot_id": [ { "id": "TAF8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQH4", "type": "external" } ], "mass": 33988.0, "length": 308, "protein_name": "Transcription initiation factor TFIID subunit 8", "gene_name": "Taf8", "organism": "Mouse", "refseq_name": "transcription initiation factor TFIID subunit 8 isoform 1", "refseq_ac": [ { "id": "NP_071298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071298", "type": "external" } ], "gene_names_uniprotkb": "Taf8; Tbn", "gene_names_refseq": "Taf8; Tbn", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 8; Protein taube nuss; TBP-associated factor 8", "protein_names_refseq": "TBP-associated factor 8; protein taube nuss; transcription initiation factor TFIID subunit 8 isoform 1; transcription initiation factor TFIID subunit 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:63856); (R-MMU-674695); (R-MMU-6804756); (R-MMU-6807505); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-76042)", "pathway_count": 8, "publication_count": 6, "publication_id_list": "11076765;14580349;29648665;34428180;34634302;35361962", "class_list": "", "function": "In contrast, loss of TAF8 in mouse embryonic stem cells and blastocysts leads to cell death and to a global decrease in Pol II transcription, [RefSeq, PubMed]; Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death., [RefSeq, PubMed]; TAF8 regions important for TFIID lobe B assembly or for TAF2 interactions are required for embryonic stem cell survival., [RefSeq, PubMed]; The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (By similarity). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (By similarity). TAF8 is involved in forming the TFIID-B module, together with TAF5 (By similarity). Mediates both basal and activator-dependent transcription (By similarity). Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts (PubMed:14580349). Required for the integration of TAF10 in the TAF complex (By similarity). May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (PubMed:11076765)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSE4;Q6PES8;Q8C382;Q8C664;Q8C7L7", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0097225 sperm midpiece;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0030154 cell differentiation;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0042789 mRNA transcription by RNA polymerase II;GO:0051457 maintenance of protein location in nucleus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9EQH4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHJ7-1", "uniprot_id": [ { "id": "TEST_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHJ7", "type": "external" } ], "mass": 36175.0, "length": 324, "protein_name": "Testisin", "gene_name": "Prss21", "organism": "Mouse", "refseq_name": "testisin precursor", "refseq_ac": [ { "id": "NP_065233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065233", "type": "external" } ], "gene_names_uniprotkb": "Prss21", "gene_names_refseq": "1700023E12Rik; Prss21; TESP5; mT4; testisin", "protein_names_uniprotkb": "Testisin; 3.4.21.-; Serine protease 21; Tryptase 4", "protein_names_refseq": "protease, serine 21; testicular serine protease 5; testisin precursor; tryptase 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:57256); (R-MMU-163125)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11231276;11259427;18754795;22362218;25428506;30911775;31219806;32511276;35820727", "class_list": "", "function": "ACR or PRSS21 or both may function cooperatively with SPAM1 in sperm/cumulus penetration, [RefSeq, PubMed]; Could regulate proteolytic events associated with testicular germ cell maturation., [UniProtKB]; Testisin inhibits metastatic ovarian tumor burden and ascites production. Testisin activity antagonizes ANG2 and ANGPTL4 synthesis and secretion. Erratum:[J Mol Med (Berl). 2019 Sep;97(9):1375. doi: 10.1007/s00109-019-01820-x. PMID: 31327018], [RefSeq, PubMed]; Testisin/Prss21 deficiency causes increased vascular permeability and a hemorrhagic phenotype during luteal angiogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; The reduced fertility of Prss21-null epididymal sperm was rescued by exposure of the sperm to the uterine microenvironment and by in vitro treatment of the sperm with uterine fluids., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9DA14", "ec_number_list": [ { "id": "3.4.11.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.9", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.1.4.50", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.50", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.4.17.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.12", "type": "external" }, { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JHJ7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJZ2-1", "uniprot_id": [ { "id": "TBA8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJZ2", "type": "external" } ], "mass": 50052.0, "length": 449, "protein_name": "Tubulin alpha-8 chain", "gene_name": "Tuba8", "organism": "Mouse", "refseq_name": "tubulin alpha-8 chain", "refseq_ac": [ { "id": "NP_059075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059075", "type": "external" } ], "gene_names_uniprotkb": "Tuba8", "gene_names_refseq": "Tuba8", "protein_names_uniprotkb": "Tubulin alpha-8 chain; 3.6.5.-; Alpha-tubulin 8", "protein_names_refseq": "alpha tubulin 8; tubulin alpha-8 chain", "tax_id": 10090, "disease": "lissencephaly (Disease Ontology:DOID:0050453); autosomal dominant isolated macrothrombocytopenia 2 (Disease Ontology:DOID:0060995); polymicrogyria (Disease Ontology:DOID:0080918); complex cortical dysplasia with other brain malformations 7 (Disease Ontology:DOID:0090132); lissencephaly 3 (Disease Ontology:DOID:0112232); microlissencephaly (Disease Ontology:DOID:0112234)", "pathway": " (mmu:53857); (R-MMU-190840); (R-MMU-2132295); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-3371497); (R-MMU-380320); (R-MMU-437239); (R-MMU-5620920); (R-MMU-5626467); (R-MMU-5663220); (R-MMU-6807878); (R-MMU-6811434); (R-MMU-6811436); (R-MMU-68877); (R-MMU-8852276); (R-MMU-8955332); (R-MMU-9646399); (R-MMU-9648025); (R-MMU-9668328); (R-MMU-983189); (R-MMU-9833482)", "pathway_count": 22, "publication_count": 10, "publication_id_list": "10772959;15890843;19524510;19896110;20466094;22645316;23897886;30033487;33414192;37507081", "class_list": "", "function": "Data (including data from studies conducted in knockout mice) suggest that Snta1 is involved in regulation of expression of Tuba8 in hepatocytes (but not in hepatic stellate cells); here, Snta1 protein levels are inversely related to Tuba8 protein expression in hepatocyte cell line. (Snta1 = syntrophin alpha-1; Tuba8 = tubulin alpha-8 chain), [RefSeq, PubMed]; This gene encodes a member of the tubulin family of cytoskeletal proteins that form the integral component of microtubules. This gene is preferentially expressed in heart, skeletal muscle and testis. The encoded protein may play a role in liver tumorigenesis in mice. [provided by RefSeq, Sep 2015]., [RefSeq]; Tuba8 is expressed at low levels in the developing mouse brain., [RefSeq, PubMed]; Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D4P911;Q9CV57", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" }, { "id": "6.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.-.-.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "5.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.1.108", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.108", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.124", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007283 spermatogenesis;GO:0007286 spermatid development;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JJZ2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKT3-1", "uniprot_id": [ { "id": "TA2R4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKT3", "type": "external" } ], "mass": 34202.0, "length": 297, "protein_name": "Taste receptor type 2 member 4", "gene_name": "Tas2r4", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 4", "refseq_ac": [ { "id": "NP_065248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065248", "type": "external" } ], "gene_names_uniprotkb": "Tas2r4; Tas2r108; Tas2r8", "gene_names_refseq": "T2R108; T2r8; Tas2r108; Tas2r4; Tas2r8; mGR08; mt2r8", "protein_names_uniprotkb": "Taste receptor type 2 member 4; T2R4; T2R8; Taste receptor type 2 member 8", "protein_names_refseq": "T2R4; candidate taste receptor T2R8; taste receptor T2R8; taste receptor type 2 member 4; taste receptor type 2 member 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:57253); (R-MMU-418594); (R-MMU-420499); (R-MMU-9717207)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10761934;10761935;11696554;12139982;12581520;14627538;15886333;21606356;26692363", "class_list": "", "function": "Data show that brush cells of the mouse trachea express the receptors Tas2R105 and Tas2R108., [RefSeq, PubMed]; Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity)., [UniProtKB]; The role of Tas2R108 in the development of obesity and adipocyte metabolism Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q53Z44", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0060170 ciliary membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JKT3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLR5-1", "uniprot_id": [ { "id": "TCF23_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLR5", "type": "external" } ], "mass": 22895.0, "length": 209, "protein_name": "Transcription factor 23", "gene_name": "Tcf23", "organism": "Mouse", "refseq_name": "transcription factor 23", "refseq_ac": [ { "id": "NP_444315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444315", "type": "external" } ], "gene_names_uniprotkb": "Tcf23; Out", "gene_names_refseq": "2010002O16Rik; Out; Tcf23; bHLHa24", "protein_names_uniprotkb": "Transcription factor 23; Basic helix-loop-helix transcription factor OUT; Ovary, uterus and testis protein; TCF-23", "protein_names_refseq": "TCF-23; basic helix-loop-helix transcription factor OUT; ovary, uterus and testis protein; transcription factor 23", "tax_id": 10090, "disease": "", "pathway": " (mmu:69852)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10652346;11701948;24571987;39014976", "class_list": "", "function": "Genomic organization and chromosome 2 mapping, [RefSeq, PubMed]; Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. May be involved in the regulation or modulation of smooth muscle contraction of the uterus during pregnancy and particularly around the time of delivery. Seems to play a role in the inhibition of myogenesis., [UniProtKB, PubMed]; Transcription Factor 23 is an Essential Determinant of Murine Term Parturition., [RefSeq, PubMed]; Transcription factor 23 (Tcf23), a basic-helix-loop-helix transcription factor, is a new progesterone-induced target gene that requires SRC-2 for full induction. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0140416 transcription regulator inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000791 euchromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation;GO:0007517 muscle organ development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JLR5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXE4-1", "uniprot_id": [ { "id": "T53I1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXE4", "type": "external" } ], "mass": 26935.0, "length": 239, "protein_name": "Tumor protein p53-inducible nuclear protein 1", "gene_name": "Trp53inp1", "organism": "Mouse", "refseq_name": "tumor protein p53-inducible nuclear protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001186034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186034", "type": "external" } ], "gene_names_uniprotkb": "Trp53inp1; Sip", "gene_names_refseq": "2700057G22Rik; SIP18; SIP27; SIP; Stinp; Teap; Tp53inp1; Trp53inp1; p53DINP1", "protein_names_uniprotkb": "Tumor protein p53-inducible nuclear protein 1; Stress-induced protein; TEAP; Thymus-expressed acidic protein; p53-dependent damage-inducible nuclear protein 1; p53DINP1", "protein_names_refseq": "p53-dependent damage-inducible nuclear protein 1; stress induced protein; thymus-expressed acidic protein; tumor protein p53-inducible nuclear protein 1 isoform 2; tumor protein p53-inducible nuclear protein 1", "tax_id": 10090, "disease": "abdominal obesity-metabolic syndrome 1 (Disease Ontology:DOID:14221)", "pathway": " (mmu:60599); (R-MMU-6804756)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10630289;11557757;12067065;16044147;19118006;21339733", "class_list": "", "function": "Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Data show that induction of the stress-induced proteins (SIPs) SIP18 and SIP27, in human- and mouse-derived cell lines, is absent from cells with deleted, mutated or inactive p53, suggesting that regulation of SIP gene expression is dependent on p53., [RefSeq, PubMed]; TP53INP1s are functionally associated with p73 to regulate cell cycle progression and apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q923I6", "ec_number_list": [], "go_molecular_function": "GO:0016209 antioxidant activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle;GO:0005776 autophagosome;GO:0016605 PML body", "go_biological_process": "GO:1904761 negative regulation of myofibroblast differentiation;GO:0000045 autophagosome assembly;GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9QXE4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1Q8-1", "uniprot_id": [ { "id": "TAGL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1Q8", "type": "external" } ], "mass": 22471.0, "length": 199, "protein_name": "Transgelin-3", "gene_name": "Tagln3", "organism": "Mouse", "refseq_name": "transgelin-3", "refseq_ac": [ { "id": "NP_062728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062728", "type": "external" } ], "gene_names_uniprotkb": "Tagln3; Np25", "gene_names_refseq": "2700038H05Rik; 2900005O10Rik; Np25; Tagln3", "protein_names_uniprotkb": "Transgelin-3; Neuronal protein NP25", "protein_names_refseq": "neuronal protein Np25; transgelin-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:56370)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40885482", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005634 nucleus;GO:0015629 actin cytoskeleton;GO:0043209 myelin sheath;GO:0045202 synapse", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9R1Q8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55055-1", "uniprot_id": [ { "id": "TRDMT_MOUSE", "url": "https://www.uniprot.org/uniprot/O55055", "type": "external" } ], "mass": 46794.0, "length": 415, "protein_name": "tRNA (cytosine(38)-C(5))-methyltransferase", "gene_name": "Trdmt1", "organism": "Mouse", "refseq_name": "tRNA (cytosine(38)-C(5))-methyltransferase isoform 1", "refseq_ac": [ { "id": "NP_034197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034197", "type": "external" } ], "gene_names_uniprotkb": "Trdmt1; Dnmt2; Met2", "gene_names_refseq": "Dnmt2; Rnmt2; Trdmt1; m.MmuIIP; met-2", "protein_names_uniprotkb": "tRNA (cytosine(38)-C(5))-methyltransferase; 2.1.1.204; DNA (cytosine-5)-methyltransferase-like protein 2; DNA MTase homolog MmuIIP; DNA methyltransferase homolog MmuIIP; Dnmt2; M.MmuIIP; Met-2", "protein_names_refseq": "DNA (cytosine-5)-methyltransferase-like protein 2; DNA MTase homolog MmuIIP; DNA methyltransferase 2; DNA methyltransferase homolog MmuIIP; tRNA (cytosine(38)-C(5))-methyltransferase isoform 1; tRNA (cytosine(38)-C(5))-methyltransferase; tRNA (cytosine-5-)-methyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:13434)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16424344;21750661;22885326;26271101;30715423;33929014;37979214;9425235;9592134", "class_list": "", "function": "Dnmt2-null sperm block maternal transmission of a paramutant phenotypedagger., [RefSeq, PubMed]; Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp) (PubMed:21183079, PubMed:22885326, PubMed:26271101). Has higher activity on tRNA(Asp) modified with queuosine at position 34 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Suppression of DNMT2/3 by proinflammatory cytokines inhibits CtBP1/2-dependent genes to promote the occurrence of atrophic nonunion., [RefSeq, PubMed]; We also show that Q-dependent stimulation of Dnmt2 is conserved in mice. Our findings reveal a direct mechanism for the regulation of translational speed and fidelity in eukaryotes by a nutrient originating from bacteria., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35212", "ec_number_list": [ { "id": "2.1.1.204", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.204", "type": "external" } ], "go_molecular_function": "GO:0008175 tRNA methyltransferase activity;GO:0016428 tRNA (cytidine-5-)-methyltransferase activity;GO:0003723 RNA binding;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0140640 catalytic activity, acting on a nucleic acid", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0008033 tRNA processing;GO:0006400 tRNA modification;GO:0030488 tRNA methylation;GO:0036416 tRNA stabilization;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O55055-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D709-1", "uniprot_id": [ { "id": "TMM79_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D709", "type": "external" } ], "mass": 43464.0, "length": 391, "protein_name": "Transmembrane protein 79", "gene_name": "Tmem79", "organism": "Mouse", "refseq_name": "transmembrane protein 79", "refseq_ac": [ { "id": "NP_077208", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077208", "type": "external" } ], "gene_names_uniprotkb": "Tmem79; Matt", "gene_names_refseq": "2310042N02Rik; 2310074C17Rik; Matt; Tmem79; ma", "protein_names_uniprotkb": "Transmembrane protein 79; Mattrin", "protein_names_refseq": "mattrin; transmembrane protein 79", "tax_id": 10090, "disease": "atopic dermatitis (Disease Ontology:DOID:3310)", "pathway": " (mmu:71913)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21750661;24060273;24084074;25428506;31219806;34428180;35752300;35820727;37474531", "class_list": "", "function": "Contributes to the epidermal integrity and skin barrier function. Plays a role in the lamellar granule (LG) secretory system and in the stratum corneum (SC) epithelial cell formation., [UniProtKB, PubMed]; Involvement of skin TRPV3 in temperature detection regulated by TMEM79 in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Microbiota-Independent Spontaneous Dermatitis Associated with Increased Sebaceous Lipid Production in Tmem79-Deficient Mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032588 trans-Golgi network membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0042335 cuticle development;GO:0045055 regulated exocytosis;GO:0061436 establishment of skin barrier;GO:0031069 hair follicle morphogenesis;GO:0002070 epithelial cell maturation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9D709-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHB3-1", "uniprot_id": [ { "id": "TIMP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHB3", "type": "external" } ], "mass": 25774.0, "length": 224, "protein_name": "Metalloproteinase inhibitor 4", "gene_name": "Timp4", "organism": "Mouse", "refseq_name": "metalloproteinase inhibitor 4 isoform 1 precursor", "refseq_ac": [ { "id": "NP_542370", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542370", "type": "external" } ], "gene_names_uniprotkb": "Timp4", "gene_names_refseq": "Timp-4; Timp4", "protein_names_uniprotkb": "Metalloproteinase inhibitor 4; TIMP-4; Tissue inhibitor of metalloproteinases 4", "protein_names_refseq": "metalloproteinase inhibitor 4 isoform 1 precursor; metalloproteinase inhibitor 4; tissue inhibitor of metalloproteinases 4", "tax_id": 10090, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); renal hypertension (Disease Ontology:DOID:1073); endometrial cancer (Disease Ontology:DOID:1380); nephroblastoma (Disease Ontology:DOID:2154); endometrial carcinoma (Disease Ontology:DOID:2871); ovarian carcinoma (Disease Ontology:DOID:4001); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); congestive heart failure (Disease Ontology:DOID:6000); abdominal aortic aneurysm (Disease Ontology:DOID:7693); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (mmu:110595)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;31677819;33792349;36459450;9013889", "class_list": "", "function": "Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor., [UniProtKB, UniProtKB, UniProtKB]; Loss of TIMP4 (Tissue Inhibitor of Metalloproteinase 4) Promotes Atherosclerotic Plaque Deposition in the Abdominal Aorta Despite Suppressed Plasma Cholesterol Levels., [RefSeq, PubMed]; The CRN2 increased the secretion of TIMP4 as well as the catalytic activity of MMP14., [RefSeq, PubMed]; Tissue inhibitor of metalloproteinase-4 deletion in mice impacts maternal cardiac function during pregnancy and postpartum., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q924B7", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008191 metalloendopeptidase inhibitor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0030017 sarcomere;GO:0005576 extracellular region", "go_biological_process": "GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:0007219 Notch signaling pathway;GO:0034097 response to cytokine;GO:0009725 response to hormone", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JHB3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VX9-1", "uniprot_id": [ { "id": "TM168_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VX9", "type": "external" } ], "mass": 79674.0, "length": 697, "protein_name": "Transmembrane protein 168", "gene_name": "Tmem168", "organism": "Mouse", "refseq_name": "transmembrane protein 168", "refseq_ac": [ { "id": "NP_083266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083266", "type": "external" } ], "gene_names_uniprotkb": "Tmem168", "gene_names_refseq": "5730526F17Rik; 8430437G11Rik; Tmem168", "protein_names_uniprotkb": "Transmembrane protein 168", "protein_names_refseq": "transmembrane protein 168", "tax_id": 10090, "disease": "", "pathway": " (mmu:101118)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;25428506;26740625;29211814;32175648;34086898;34428180", "class_list": "", "function": "Plays a key role in maintaining the cardiac electrical stability by modulating cell surface expression of SCN5A (PubMed:32175648). Plays a role i the modulation of anxiety behavior by regulating GABAergic neuronal system in the nucleus accumbens (PubMed:29211814)., [UniProtKB, PubMed, PubMed]; Transmembrane protein 168 mutation reduces cardiomyocyte cell surface expression of Nav1.5 through alphaB-crystallin intracellular dynamics. Erratum:[J Biochem. 2022 Mar 31;171(4):467. doi: 10.1093/jb/mvab152. PMID: 35137094], [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDA5", "ec_number_list": [], "go_molecular_function": "GO:0017080 sodium channel regulator activity", "go_cellular_component": "GO:0031965 nuclear membrane;GO:0030133 transport vesicle", "go_biological_process": "GO:1905150 regulation of voltage-gated sodium channel activity;GO:2000058 regulation of ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91VX9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VBF2-1", "uniprot_id": [ { "id": "TM52B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0VBF2", "type": "external" } ], "mass": 20312.0, "length": 186, "protein_name": "Transmembrane protein 52B", "gene_name": "Tmem52b", "organism": "Mouse", "refseq_name": "transmembrane protein 52B precursor", "refseq_ac": [ { "id": "NP_001074655", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074655", "type": "external" } ], "gene_names_uniprotkb": "Tmem52b", "gene_names_refseq": "D630042F21Rik; Tmem52b", "protein_names_uniprotkb": "Transmembrane protein 52B", "protein_names_refseq": "transmembrane protein 52B precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:330428)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VBF2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q149F5-1", "uniprot_id": [ { "id": "TMM71_MOUSE", "url": "https://www.uniprot.org/uniprot/Q149F5", "type": "external" } ], "mass": 31871.0, "length": 287, "protein_name": "Transmembrane protein 71", "gene_name": "Tmem71", "organism": "Mouse", "refseq_name": "transmembrane protein 71", "refseq_ac": [ { "id": "NP_766102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766102", "type": "external" } ], "gene_names_uniprotkb": "Tmem71", "gene_names_refseq": "E430024D12; Tmem71", "protein_names_uniprotkb": "Transmembrane protein 71", "protein_names_refseq": "transmembrane protein 71", "tax_id": 10090, "disease": "", "pathway": " (mmu:213068)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2F7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q149F5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83626-1", "uniprot_id": [ { "id": "TNR26_MOUSE", "url": "https://www.uniprot.org/uniprot/P83626", "type": "external" } ], "mass": 22708.0, "length": 204, "protein_name": "Tumor necrosis factor receptor superfamily member 26", "gene_name": "Tnfrsf26", "organism": "Mouse", "refseq_name": "tumor necrosis factor receptor superfamily member 26 precursor", "refseq_ac": [ { "id": "NP_783580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783580", "type": "external" } ], "gene_names_uniprotkb": "Tnfrsf26; Tnfrh3", "gene_names_refseq": "Tnfrh3; Tnfrsf24; Tnfrsf26", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 26; TNF receptor homolog 3", "protein_names_refseq": "TNF receptor homolog 3; tumor necrosis factor receptor superfamily member 26 precursor; tumor necrosis factor receptor superfamily, member 24", "tax_id": 10090, "disease": "", "pathway": " (mmu:244237)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12466268;21750661", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P83626-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCC8-1", "uniprot_id": [ { "id": "TOM20_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCC8", "type": "external" } ], "mass": 16284.0, "length": 145, "protein_name": "Mitochondrial import receptor subunit TOM20 homolog", "gene_name": "Tomm20", "organism": "Mouse", "refseq_name": "mitochondrial import receptor subunit TOM20 homolog", "refseq_ac": [ { "id": "NP_077176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077176", "type": "external" } ], "gene_names_uniprotkb": "Tomm20", "gene_names_refseq": "1810060K07Rik; Gm19268; MAS20; MOM19; TOM20; Tomm20; mKIAA0016", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM20 homolog; Mitochondrial 20 kDa outer membrane protein; Outer mitochondrial membrane receptor Tom20", "protein_names_refseq": "mitochondrial 20 kDa outer membrane protein; mitochondrial import receptor subunit TOM20 homolog; outer mitochondrial membrane receptor Tom20; translocase of outer mitochondrial membrane 20 homolog", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (mmu:67952); (R-MMU-5205685); (R-MMU-5689880)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "19492028;21183079;21750661;32976492;34428180", "class_list": "", "function": "Central receptor component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). Together with TOMM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0015450 protein-transporting ATPase activity;GO:0030943 mitochondrion targeting sequence binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005740 mitochondrial envelope;GO:0005741 mitochondrial outer membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site;GO:0071944 cell periphery", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006626 protein targeting to mitochondrion;GO:0014850 response to muscle activity;GO:0030150 protein import into mitochondrial matrix;GO:1905242 response to 3,3',5-triiodo-L-thyronine", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DCC8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHJ0-1", "uniprot_id": [ { "id": "TMOD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JHJ0", "type": "external" } ], "mass": 39503.0, "length": 352, "protein_name": "Tropomodulin-3", "gene_name": "Tmod3", "organism": "Mouse", "refseq_name": "tropomodulin-3 isoform 1", "refseq_ac": [ { "id": "NP_058659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058659", "type": "external" } ], "gene_names_uniprotkb": "Tmod3", "gene_names_refseq": "Tmod3; U-Tmod; UTMOD", "protein_names_uniprotkb": "Tropomodulin-3; U-Tmod; Ubiquitous tropomodulin", "protein_names_refseq": "tropomodulin 3; tropomodulin-3 isoform 1; ubiquitous tropomodulin", "tax_id": 10090, "disease": "nemaline myopathy (Disease Ontology:DOID:3191)", "pathway": " (mmu:50875); (R-MMU-390522); (R-MMU-9013418); (R-MMU-9696264)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10662549;18299400;21183079;21750661;22645316;24788674;28528544;33959097;34428180;34718575;35195928;36210013;37126682;37453647", "class_list": "", "function": "Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity)., [UniProtKB]; Erythroid differentiation in mouse erythroleukemia cells depends on Tmod3-mediated regulation of actin filament assembly into the erythroblast membrane skeleton., [RefSeq, PubMed]; Heterozygous Tropomodulin 3 mice have improved lung vascularization after chronic hypoxia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIT1", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005523 tropomyosin binding;GO:0051011 microtubule minus-end binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0030027 lamellipodium;GO:0005865 striated muscle thin filament;GO:0001726 ruffle;GO:0030016 myofibril", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0030036 actin cytoskeleton organization;GO:0048870 cell motility;GO:0048821 erythrocyte development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9JHJ0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D4V6-1", "uniprot_id": [ { "id": "TO20L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D4V6", "type": "external" } ], "mass": 17580.0, "length": 152, "protein_name": "TOMM20-like protein 1", "gene_name": "Tomm20l", "organism": "Mouse", "refseq_name": "TOMM20-like protein 1", "refseq_ac": [ { "id": "NP_083503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083503", "type": "external" } ], "gene_names_uniprotkb": "Tomm20l", "gene_names_refseq": "4930553D19Rik; Tomm20l", "protein_names_uniprotkb": "TOMM20-like protein 1", "protein_names_refseq": "TOMM20-like protein 1; translocase of outer mitochondrial membrane 20 homolog-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:75266)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030943 mitochondrion targeting sequence binding", "go_cellular_component": "GO:0005742 mitochondrial outer membrane translocase complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006605 protein targeting;GO:0030150 protein import into mitochondrial matrix;GO:0016031 tRNA import into mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D4V6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2ACG1-1", "uniprot_id": [ { "id": "TLDC2_MOUSE", "url": "https://www.uniprot.org/uniprot/A2ACG1", "type": "external" } ], "mass": 21987.0, "length": 198, "protein_name": "TLD domain-containing protein 2", "gene_name": "Tldc2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tldc2; Gm1332", "gene_names_refseq": "", "protein_names_uniprotkb": "TLD domain-containing protein 2; TBC/LysM-associated domain-containing protein 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "cerebellar hyplasia/atrophy, epilepsy, and global developmental delay (Disease Ontology:DOID:0070339)", "pathway": " (mmu:383766)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;26668325;34811399;40358928", "class_list": "", "function": "Inhibits the activity of the vacuolar-type ATPase (V-ATPase) by inducing disassembly of the V-ATPase complex (By similarity). Protects neuronal cells against oxidative stress (PubMed:26668325). Required for kidney bicarbonate secretion (PubMed:40358928)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006979 response to oxidative stress;GO:1900408 negative regulation of cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2ACG1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH55-1", "uniprot_id": [ { "id": "THNS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH55", "type": "external" } ], "mass": 83100.0, "length": 747, "protein_name": "Threonine synthase-like 1", "gene_name": "Thnsl1", "organism": "Mouse", "refseq_name": "threonine synthase-like 1 isoform b", "refseq_ac": [ { "id": "NP_001001297", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001297", "type": "external" } ], "gene_names_uniprotkb": "Thnsl1", "gene_names_refseq": "Thnsl1", "protein_names_uniprotkb": "Threonine synthase-like 1; TSH1", "protein_names_refseq": "TSH1; threonine synthase-like 1 isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:208967)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;30084848;30779550", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BH55-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1ATG9-1", "uniprot_id": [ { "id": "TIKI2_MOUSE", "url": "https://www.uniprot.org/uniprot/B1ATG9", "type": "external" } ], "mass": 57368.0, "length": 517, "protein_name": "Metalloprotease TIKI2", "gene_name": "Trabd2b", "organism": "Mouse", "refseq_name": "metalloprotease TIKI2 precursor", "refseq_ac": [ { "id": "NP_001079018", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001079018", "type": "external" } ], "gene_names_uniprotkb": "Trabd2b; Gm12824; Hkat; Tiki2", "gene_names_refseq": "Gm12824; Hkat; Trabd2b", "protein_names_uniprotkb": "Metalloprotease TIKI2; 3.4.-.-; Heart, kidney and adipose-enriched transmembrane protein; TRAB domain-containing protein 2B", "protein_names_refseq": "TRAB domain-containing protein 2B; UPF0632 protein A; heart, kidney and adipose-enriched transmembrane protein; metalloprotease TIKI2 precursor; metalloprotease TIKI2", "tax_id": 10090, "disease": "", "pathway": " (mmu:666048)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23152936;34428180", "class_list": "", "function": "Hkat (Gm12824) is a novel nutritionally regulated gene that is potentially involved in metabolism., [RefSeq, PubMed]; Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 2, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0031090 organelle membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0031334 positive regulation of protein-containing complex assembly;GO:0016055 Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B1ATG9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P69525-1", "uniprot_id": [ { "id": "TMPS9_MOUSE", "url": "https://www.uniprot.org/uniprot/P69525", "type": "external" } ], "mass": 114486.0, "length": 1065, "protein_name": "Transmembrane protease serine 9", "gene_name": "Tmprss9", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tmprss9", "gene_names_refseq": "", "protein_names_uniprotkb": "Transmembrane protease serine 9; 3.4.21.-; Polyserase-1; Polyserase-I; Polyserine protease 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:432478)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12886014;21750661", "class_list": "", "function": "Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0031639 plasminogen activation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P69525-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R183-1", "uniprot_id": [ { "id": "TIMD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R183", "type": "external" } ], "mass": 33504.0, "length": 305, "protein_name": "T-cell immunoglobulin and mucin domain-containing protein 2", "gene_name": "Timd2", "organism": "Mouse", "refseq_name": "T-cell immunoglobulin and mucin domain-containing protein 2 precursor", "refseq_ac": [ { "id": "NP_001154827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001154827", "type": "external" } ], "gene_names_uniprotkb": "Timd2; Tim2", "gene_names_refseq": "G9D3; TIM-2; Tim2; Timd2", "protein_names_uniprotkb": "T-cell immunoglobulin and mucin domain-containing protein 2; T-cell immunoglobulin mucin receptor 2; T-cell membrane protein 2; TIM-2; TIMD-2", "protein_names_refseq": "T-cell immunoglobulin and mucin domain-containing protein 2 precursor; T-cell immunoglobulin and mucin domain-containing protein 2; T-cell immunoglobulin mucin receptor 2; T-cell membrane protein 2; TIMD-2", "tax_id": 10090, "disease": "essential hypertension (Disease Ontology:DOID:10825); hydronephrosis (Disease Ontology:DOID:11111); acute kidney tubular necrosis (Disease Ontology:DOID:12556); renovascular hypertension (Disease Ontology:DOID:1591); hyperuricemia (Disease Ontology:DOID:1920); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); asthma (Disease Ontology:DOID:2841); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); atopic dermatitis (Disease Ontology:DOID:3310); renal cell carcinoma (Disease Ontology:DOID:4450); kidney disease (Disease Ontology:DOID:557); hepatocellular carcinoma (Disease Ontology:DOID:684); vesicoureteral reflux (Disease Ontology:DOID:9620)", "pathway": " (mmu:171284)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11725301;12374982;16043519;16203866;17015678;17363299;21750661;21886823;22469568;33065090;34428180", "class_list": "", "function": "Cell surface glycoprotein that participates in iron homeostasis in the liver, the kidney, the retina and oligodendrocytes by acting as a receptor of H-ferritin (PubMed:16203866, PubMed:33065090). Mechanistically, mediates iron-containing ferritin uptake via an endocytic pathway, trafficking to endosomes and subsequently to lysosomes (PubMed:16043519, PubMed:21886823). Plays also an important role in the regulation of Th2 immunity (PubMed:16043519). Receptor for SEMA4A involved in the regulation of T-cell function, enhancing T-cell activation (PubMed:12374982)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Expression of TIM-2 significantly impairs the induction of NFAT and AP-1 transcriptional reporters, [RefSeq, PubMed]; TIM-2 can function as an iron uptake pathway., [RefSeq, PubMed]; TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis., [RefSeq, PubMed]; We concluded that pro-apoptotic effects on Th1 population through galectin-9-Tim-3 pathway and the up-regulation of Tim-2 on Th2 cells might be critical to Th2-biased response of host with schistosomiasis japonica., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8VBW0", "ec_number_list": [], "go_molecular_function": "GO:0070287 ferritin receptor activity;GO:0001618 virus receptor activity;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031514 motile cilium", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0006826 iron ion transport;GO:0033005 positive regulation of mast cell activation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8R183-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52875-1", "uniprot_id": [ { "id": "TM165_MOUSE", "url": "https://www.uniprot.org/uniprot/P52875", "type": "external" } ], "mass": 34791.0, "length": 323, "protein_name": "Putative divalent cation/proton antiporter TMEM165", "gene_name": "Tmem165", "organism": "Mouse", "refseq_name": "putative divalent cation/proton antiporter TMEM165 precursor", "refseq_ac": [ { "id": "NP_035756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035756", "type": "external" } ], "gene_names_uniprotkb": "Tmem165; Tparl", "gene_names_refseq": "Tmem165; Tpardl; Tparl; pFT27", "protein_names_uniprotkb": "Putative divalent cation/proton antiporter TMEM165; TPA-regulated locus protein; Transmembrane protein 165; Transmembrane protein PFT27; Transmembrane protein TPARL", "protein_names_refseq": "TPA regulated locus; TPA-regulated locus protein; putative divalent cation/proton antiporter TMEM165 precursor; putative divalent cation/proton antiporter TMEM165; transmembrane protein 164; transmembrane protein PFT27; transmembrane protein TPARL", "tax_id": 10090, "disease": "congenital disorder of glycosylation type II (Disease Ontology:DOID:0050571); congenital disorder of glycosylation type IIk (Disease Ontology:DOID:0070263)", "pathway": " (mmu:21982)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11116088;21750661;24530912;25428506;30622138;3202867;34930890", "class_list": "", "function": "Putative divalent cation:proton antiporter that exchanges calcium or manganese ions for protons across the Golgi membrane. Mediates the reversible transport of calcium or manganese to the Golgi lumen driven by the proton gradient and possibly the membrane potential generated by V-ATPase. Provides calcium or manganese cofactors to resident Golgi enzymes and contributes to the maintenance of an acidic luminal Golgi pH required for proper functioning of the secretory pathway (By similarity). Promotes Ca(2+) storage within the Golgi lumen of the mammary epithelial cells to be then secreted into milk (PubMed:30622138). The transport mechanism and stoichiometry remains to be elucidated (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; TMEM165 a new player in proteoglycan synthesis: loss of TMEM165 impairs elongation of chondroitin- and heparan-sulfate glycosaminoglycan chains of proteoglycans and triggers early chondrocyte differentiation and hypertrophy. Publication Status: Online-Only, [RefSeq, PubMed]; The timing, magnitude of TMEM165 expression and its Golgi location supports a role for this Golgi Ca2+/H+ antiporter as a contributor to mammary Golgi calcium transport needs, in addition to the better-characterized roles of SPCA1 and 2., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9R292", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0015085 calcium ion transmembrane transporter activity;GO:0005384 manganese ion transmembrane transporter activity;GO:0046873 metal ion transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0032588 trans-Golgi network membrane;GO:0005765 lysosomal membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0006487 protein N-linked glycosylation;GO:0070588 calcium ion transmembrane transport;GO:0006828 manganese ion transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P52875-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KL18-1", "uniprot_id": [ { "id": "TM171_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4KL18", "type": "external" } ], "mass": 34585.0, "length": 322, "protein_name": "Transmembrane protein 171", "gene_name": "Tmem171", "organism": "Mouse", "refseq_name": "transmembrane protein 171 isoform 2", "refseq_ac": [ { "id": "NP_001020777", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020777", "type": "external" } ], "gene_names_uniprotkb": "Tmem171; Gm905", "gene_names_refseq": "Gm905; Tmem171", "protein_names_uniprotkb": "Transmembrane protein 171", "protein_names_refseq": "transmembrane protein 171 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:380863)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4KL18-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25119-1", "uniprot_id": [ { "id": "TNR1B_MOUSE", "url": "https://www.uniprot.org/uniprot/P25119", "type": "external" } ], "mass": 50320.0, "length": 474, "protein_name": "Tumor necrosis factor receptor superfamily member 1B", "gene_name": "Tnfrsf1b", "organism": "Mouse", "refseq_name": "tumor necrosis factor receptor superfamily member 1B precursor", "refseq_ac": [ { "id": "NP_035740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035740", "type": "external" } ], "gene_names_uniprotkb": "Tnfrsf1b; Tnfr-2; Tnfr2", "gene_names_refseq": "CD120b; TNF-R-II; TNF-R2; TNF-R75; TNF-alphaR2; TNFBR; TNFR80; TNFRII; TNFalpha-R2; Tnfr-1; Tnfr2; Tnfrsf1b; p75", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 1B; TNF-R2; TNF-RII; TNFR-II; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor type II; p75; p80 TNF-alpha receptor", "protein_names_refseq": "TNF receptor beta chain; TNF-RII; TNFR-II; p75 TNFR; p80 TNF-alpha receptor; tumor necrosis factor receptor 2; tumor necrosis factor receptor superfamily member 1B precursor; tumor necrosis factor receptor type II", "tax_id": 10090, "disease": "cryptogenic organizing pneumonia (Disease Ontology:DOID:0050157); lupus nephritis (Disease Ontology:DOID:0080162); polymyositis (Disease Ontology:DOID:0080745); Parkinsonism (Disease Ontology:DOID:0080855); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); kidney failure (Disease Ontology:DOID:1074); essential hypertension (Disease Ontology:DOID:10825); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); osteoporosis (Disease Ontology:DOID:11476); pulmonary sarcoidosis (Disease Ontology:DOID:13406); endometrial cancer (Disease Ontology:DOID:1380); familial combined hyperlipidemia (Disease Ontology:DOID:13809); colon carcinoma (Disease Ontology:DOID:1520); ovarian cancer (Disease Ontology:DOID:2394); endometriosis (Disease Ontology:DOID:289); glomerulonephritis (Disease Ontology:DOID:2921); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); tuberculosis (Disease Ontology:DOID:399); renal cell carcinoma (Disease Ontology:DOID:4450); ureteral obstruction (Disease Ontology:DOID:5199); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); acne (Disease Ontology:DOID:6543); ankylosing spondylitis (Disease Ontology:DOID:7147); end stage renal disease (Disease Ontology:DOID:783); extrinsic allergic alveolitis (Disease Ontology:DOID:841); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:21938); (R-MMU-5668541); (R-MMU-5669034); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "11801660;1645445;1849278;21750661;9740674", "class_list": "", "function": "Receptor with high affinity for TNFSF2/TNF and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity)., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 2, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 35, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O88734;P97893", "ec_number_list": [], "go_molecular_function": "GO:0043120 tumor necrosis factor binding;GO:0031625 ubiquitin protein ligase binding;GO:0005031 tumor necrosis factor receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0045121 membrane raft", "go_biological_process": "GO:0050779 RNA destabilization;GO:0002718 regulation of cytokine production involved in immune response;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P25119-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR75-1", "uniprot_id": [ { "id": "TNR12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR75", "type": "external" } ], "mass": 13641.0, "length": 129, "protein_name": "Tumor necrosis factor receptor superfamily member 12A", "gene_name": "Tnfrsf12a", "organism": "Mouse", "refseq_name": "tumor necrosis factor receptor superfamily member 12A isoform 2", "refseq_ac": [ { "id": "NP_001155218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155218", "type": "external" } ], "gene_names_uniprotkb": "Tnfrsf12a; Fgfrp2; Fn14", "gene_names_refseq": "Fn14; HPIP; TWEAK-R; Tnfrsf12a; TweakR", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 12A; FGF-inducible 14; Fibroblast growth factor-inducible immediate-early response protein 14; Fibroblast growth factor-regulated protein 2; Tweak-receptor; TweakR", "protein_names_refseq": "FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 14; fibroblast growth factor-regulated protein 2; tumor necrosis factor receptor superfamily member 12A isoform 2; tweak-receptor; type I transmembrane protein Fn14", "tax_id": 10090, "disease": "", "pathway": " (mmu:27279); (R-MMU-5668541); (R-MMU-5676594)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10551889;12529173;12794080;21750661", "class_list": "", "function": "Findings show that the Fn14/TWEAK receptor (TweakR) was not responsible for the osteoclastic effect of TWEAK on RAW cells, [RefSeq, PubMed]; Receptor for TNFSF12/TWEAK (By similarity). Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins., [UniProtKB]; Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins., [UniProtKB, UniProtKB]; The cytoplasmic tail of this protein binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVG8;Q9QZW3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0001726 ruffle", "go_biological_process": "GO:0061041 regulation of wound healing;GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0030154 cell differentiation;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CR75-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D4Y8-1", "uniprot_id": [ { "id": "TM269_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D4Y8", "type": "external" } ], "mass": 28198.0, "length": 254, "protein_name": "Transmembrane protein 269", "gene_name": "Tmem269", "organism": "Mouse", "refseq_name": "transmembrane protein 269", "refseq_ac": [ { "id": "NP_083474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083474", "type": "external" } ], "gene_names_uniprotkb": "Tmem269; 4930538K18Rik", "gene_names_refseq": "4930538K18Rik; Tmem269", "protein_names_uniprotkb": "Transmembrane protein 269", "protein_names_refseq": "transmembrane protein 269", "tax_id": 10090, "disease": "", "pathway": " (mmu:75180)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D4Y8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49813-1", "uniprot_id": [ { "id": "TMOD1_MOUSE", "url": "https://www.uniprot.org/uniprot/P49813", "type": "external" } ], "mass": 40466.0, "length": 359, "protein_name": "Tropomodulin-1", "gene_name": "Tmod1", "organism": "Mouse", "refseq_name": "tropomodulin-1 isoform 1", "refseq_ac": [ { "id": "NP_068683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068683", "type": "external" } ], "gene_names_uniprotkb": "Tmod1; Tmod", "gene_names_refseq": "E-Tmod; Tmod1; Tmod", "protein_names_uniprotkb": "Tropomodulin-1; E-Tmod; Erythrocyte tropomodulin", "protein_names_refseq": "erythrocyte tropomodulin; tropomodulin-1 isoform 1", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:21916); (R-MMU-390522)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "11054557;18299400;20173027;21750661;21952136;25428506;25605945;30084848;30779550;33552047;34203471;34428180;35820727;39276234;7851652", "class_list": "", "function": "Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity)., [UniProtKB]; Tropomodulin1 Expression Increases Upon Maturation in Dendritic Cells and Promotes Their Maturation and Immune Functions. Publication Status: Online-Only, [RefSeq, PubMed]; Tropomodulin1 exacerbates inflammatory response in macrophages by negatively regulating LPS-induced TLR4 endocytosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KP84;Q9ERR9", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005523 tropomyosin binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005884 actin filament;GO:0016020 membrane;GO:0005865 striated muscle thin filament;GO:0030017 sarcomere", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0008344 adult locomotory behavior;GO:0051694 pointed-end actin filament capping;GO:0070307 lens fiber cell development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P49813-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80W03-1", "uniprot_id": [ { "id": "TOX3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80W03", "type": "external" } ], "mass": 63174.0, "length": 575, "protein_name": "TOX high mobility group box family member 3", "gene_name": "Tox3", "organism": "Mouse", "refseq_name": "TOX high mobility group box family member 3 isoform 1", "refseq_ac": [ { "id": "NP_766501", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766501", "type": "external" } ], "gene_names_uniprotkb": "Tox3; Tnrc9", "gene_names_refseq": "500-9; C230068E13; CAGF9; Tnrc9; Tox3", "protein_names_uniprotkb": "TOX high mobility group box family member 3; Trinucleotide repeat-containing gene 9 protein", "protein_names_refseq": "TOX high mobility group box family member 3 isoform 1; trinucleotide repeat containing 9; trinucleotide repeat-containing gene 9 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:244579)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;38145825", "class_list": "", "function": "TOX3 deficiency mitigates hyperglycemia by suppressing hepatic gluconeogenesis through FoxO1., [RefSeq, PubMed]; Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BIV8", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0042803 protein homodimerization activity;GO:0051219 phosphoprotein binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0019722 calcium-mediated signaling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80W03-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62077-1", "uniprot_id": [ { "id": "TIM8B_MOUSE", "url": "https://www.uniprot.org/uniprot/P62077", "type": "external" } ], "mass": 9286.0, "length": 83, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim8 B", "gene_name": "Timm8b", "organism": "Mouse", "refseq_name": "mitochondrial import inner membrane translocase subunit Tim8 B", "refseq_ac": [ { "id": "NP_038925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038925", "type": "external" } ], "gene_names_uniprotkb": "Timm8b; Ddp2; Tim8b", "gene_names_refseq": "Tim8b; Timm8b", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim8 B; Deafness dystonia protein 2 homolog", "protein_names_refseq": "deafness dystonia protein 2 homolog; mitochondrial import inner membrane translocase subunit Tim8 B; translocase of inner mitochondrial membrane 8 homolog b", "tax_id": 10090, "disease": "deafness-dystonia-optic neuronopathy syndrome (Disease Ontology:DOID:0050757)", "pathway": " (mmu:30057)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10611480;30084848;34428180", "class_list": "", "function": "Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TF77;Q9QUT4", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P62077-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06806-1", "uniprot_id": [ { "id": "TIE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q06806", "type": "external" } ], "mass": 124583.0, "length": 1134, "protein_name": "Tyrosine-protein kinase receptor Tie-1", "gene_name": "Tie1", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase receptor Tie-1 precursor", "refseq_ac": [ { "id": "NP_035717", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035717", "type": "external" } ], "gene_names_uniprotkb": "Tie1; Tie-1; Tie", "gene_names_refseq": "D430008P04Rik; TIE; Tie1; tie-1", "protein_names_uniprotkb": "Tyrosine-protein kinase receptor Tie-1; 2.7.10.1", "protein_names_refseq": "tyrosine kinase receptor 1; tyrosine-protein kinase receptor Tie-1 precursor; tyrosine-protein kinase receptor Tie-1", "tax_id": 10090, "disease": "hereditary lymphedema (Disease Ontology:DOID:0050580)", "pathway": " (mmu:21846)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11865050;1384789;28179430;30084848;30779550;34428180;37338522;7655012;8395828;8415706", "class_list": "", "function": "Polydom/SVEP1 binds to Tie1 and promotes migration of lymphatic endothelial cells., [RefSeq, PubMed]; Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q811F4;Q8BGI2", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0001701 in utero embryonic development;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0030336 negative regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q06806-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2LA85-1", "uniprot_id": [ { "id": "TRML2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q2LA85", "type": "external" } ], "mass": 37075.0, "length": 329, "protein_name": "Trem-like transcript 2 protein", "gene_name": "Treml2", "organism": "Mouse", "refseq_name": "trem-like transcript 2 protein isoform 1 precursor", "refseq_ac": [ { "id": "NP_001028577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028577", "type": "external" } ], "gene_names_uniprotkb": "Treml2; Tlt2", "gene_names_refseq": "Gm750; Tlt2; Treml2", "protein_names_uniprotkb": "Trem-like transcript 2 protein; TLT-2; Triggering receptor expressed on myeloid cells-like protein 2", "protein_names_refseq": "trem-like transcript 2 protein isoform 1 precursor; trem-like transcript 2 protein; triggering receptor expressed on myeloid cells-like 2a dominant; triggering receptor expressed on myeloid cells-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:328833); (R-MMU-198933)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16670310;18650384;19544488;20141543;21750661;21804015;22573805;27143430", "class_list": "", "function": "(+) T-cell effector function, possibly by ligation of TLT-2 on tumour-infiltrating CD8(+) T cells at the local tumour site., [RefSeq, PubMed]; Analysis of an interaction between B7-H3 and TLT-2 that preferentially enhances CD8(+) T cell activation Erratum:[Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14744], [RefSeq, PubMed]; Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Data do not point to a role for TREML2 as a receptor for B7-H3., [RefSeq, PubMed]; TLT2 ligation enhances the neutrophil response to the formylated peptide FMLF, leading to increased reactive oxygen species production, degranulation, and chemotaxis, [RefSeq, PubMed]; TLT2 may be involved in the innate immune response based on its expression profile and the fact that it is up-regulated in response to inflammation., [RefSeq, PubMed]; TREM2 and TREML2 play opposite roles in microglia activation, [RefSeq, PubMed]; Thus, our studies identified TLT2 as an engulfment receptor for apoptotic cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6XA76", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0042110 T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q2LA85-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TUD9-1", "uniprot_id": [ { "id": "TMM18_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TUD9", "type": "external" } ], "mass": 16526.0, "length": 140, "protein_name": "Transmembrane protein 18", "gene_name": "Tmem18", "organism": "Mouse", "refseq_name": "transmembrane protein 18", "refseq_ac": [ { "id": "NP_742046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742046", "type": "external" } ], "gene_names_uniprotkb": "Tmem18", "gene_names_refseq": "Tmem18", "protein_names_uniprotkb": "Transmembrane protein 18", "protein_names_refseq": "transmembrane protein 18", "tax_id": 10090, "disease": "abdominal obesity-metabolic syndrome 1 (Disease Ontology:DOID:14221); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:211986)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CID7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0016477 cell migration;GO:0042755 eating behavior;GO:0097009 energy homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3TUD9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TYP4-1", "uniprot_id": [ { "id": "TM278_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TYP4", "type": "external" } ], "mass": 18549.0, "length": 173, "protein_name": "Transmembrane protein 278", "gene_name": "Tmem278", "organism": "Mouse", "refseq_name": "transmembrane protein 278", "refseq_ac": [ { "id": "NP_001028566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028566", "type": "external" } ], "gene_names_uniprotkb": "Tmem278; Tmem88b", "gene_names_refseq": "A230069A22Rik; Tmem278; Tmem88b", "protein_names_uniprotkb": "Transmembrane protein 278; Transmembrane protein 88B", "protein_names_refseq": "transmembrane protein 278; transmembrane protein 88B", "tax_id": 10090, "disease": "", "pathway": " (mmu:320587)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AD92", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3TYP4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UHI4-1", "uniprot_id": [ { "id": "TMED8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UHI4", "type": "external" } ], "mass": 35785.0, "length": 326, "protein_name": "Protein TMED8", "gene_name": "Tmed8", "organism": "Mouse", "refseq_name": "protein TMED8", "refseq_ac": [ { "id": "NP_001028647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028647", "type": "external" } ], "gene_names_uniprotkb": "Tmed8", "gene_names_refseq": "6430595O10Rik; Gm1184; Mem1; Tmed8", "protein_names_uniprotkb": "Protein TMED8", "protein_names_refseq": "maternal embryonic message 1; protein TMED8; transmembrane emp24 domain containing 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:382620)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3UHI4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q499M4-1", "uniprot_id": [ { "id": "TIGD5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q499M4", "type": "external" } ], "mass": 70249.0, "length": 642, "protein_name": "Tigger transposable element derived 5", "gene_name": "Tigd5", "organism": "Mouse", "refseq_name": "tigger transposable element derived 5", "refseq_ac": [ { "id": "NP_848761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848761", "type": "external" } ], "gene_names_uniprotkb": "Tigd5", "gene_names_refseq": "Tigd5", "protein_names_uniprotkb": "Tigger transposable element derived 5", "protein_names_refseq": "tigger transposable element derived 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:105734)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQA1;Q8C381;Q8CBD5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007379 segment specification;GO:0021556 central nervous system formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q499M4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4FZG7-1", "uniprot_id": [ { "id": "TI8AB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4FZG7", "type": "external" } ], "mass": 11283.0, "length": 97, "protein_name": "Putative mitochondrial import inner membrane translocase subunit Tim8 A-B", "gene_name": "Timm8a2", "organism": "Mouse", "refseq_name": "putative mitochondrial import inner membrane translocase subunit Tim8 A-B", "refseq_ac": [ { "id": "NP_001032833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032833", "type": "external" } ], "gene_names_uniprotkb": "Timm8a2; Timm8ab", "gene_names_refseq": "Timm8a2", "protein_names_uniprotkb": "Putative mitochondrial import inner membrane translocase subunit Tim8 A-B", "protein_names_refseq": "putative mitochondrial import inner membrane translocase subunit Tim8 A-B; translocase of inner mitochondrial membrane 8 homolog a2", "tax_id": 10090, "disease": "deafness-dystonia-optic neuronopathy syndrome (Disease Ontology:DOID:0050757)", "pathway": " (mmu:223262)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0015031 protein transport;GO:0072655 establishment of protein localization to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4FZG7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5K6N0-1", "uniprot_id": [ { "id": "TM232_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5K6N0", "type": "external" } ], "mass": 78275.0, "length": 675, "protein_name": "Transmembrane protein 232", "gene_name": "Tmem232", "organism": "Mouse", "refseq_name": "transmembrane protein 232 isoform a", "refseq_ac": [ { "id": "NP_001008973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008973", "type": "external" } ], "gene_names_uniprotkb": "Tmem232; Tes13", "gene_names_refseq": "E130009J12Rik; Gm940; Tes13-L; Tes13-S; Tmem232", "protein_names_uniprotkb": "Transmembrane protein 232; Testis-specific protein 13", "protein_names_refseq": "testis-specific protein 13; transmembrane protein 232 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:381107)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;36928730;37371084", "class_list": "", "function": "Deficiency of the Tmem232 Gene Causes Male Infertility with Morphological Abnormalities of the Sperm Flagellum in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a critical role for male fertility and sperm motility by regulating sperm cytoplasm removal and maintaining axoneme integrity., [UniProtKB, PubMed]; TMEM232 promotes the inflammatory response in atopic dermatitis via the nuclear factor-kappaB and signal transducer and activator of transcription 3 signalling pathways. Erratum:[Br J Dermatol. 2023 Oct 25;189(5):e83-e87. doi: 10.1093/bjd/ljad346. PMID: 37742065], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RX35;B7ZWG2;Q5K6N1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001520 outer dense fiber;GO:0016020 membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0030030 cell projection organization;GO:0098544 maintenance of protein complex location;GO:0160087 spermatid cytoplasm removal during spermiation of flagellated sperm", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5K6N0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7L8-1", "uniprot_id": [ { "id": "TMIG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7L8", "type": "external" } ], "mass": 29051.0, "length": 261, "protein_name": "Transmembrane and immunoglobulin domain-containing protein 1", "gene_name": "Tmigd1", "organism": "Mouse", "refseq_name": "transmembrane and immunoglobulin domain-containing protein 1 isoform 2 precursor", "refseq_ac": [ { "id": "NP_079931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079931", "type": "external" } ], "gene_names_uniprotkb": "Tmigd1; Tmigd", "gene_names_refseq": "2010002A20Rik; Tmigd1; Tmigd", "protein_names_uniprotkb": "Transmembrane and immunoglobulin domain-containing protein 1", "protein_names_refseq": "transmembrane and immunoglobulin domain-containing protein 1 isoform 2 precursor; transmembrane and immunoglobulin domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66601)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;33129760;34426761;34503512;35820727;36099341;37301121;37542259", "class_list": "", "function": "Decreased TMIGD1 aggravates colitis and intestinal barrier dysfunction via the BANF1-NF-kappaB pathway in Crohn's disease. Publication Status: Online-Only, [RefSeq, PubMed]; Intestinal brush border formation requires a TMIGD1-based intermicrovillar adhesion complex., [RefSeq, PubMed]; Macrophage-derived exosomes promote intestinal mucosal barrier dysfunction in inflammatory bowel disease by regulating TMIGD1 via mircroRNA-223., [RefSeq, PubMed]; May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival., [UniProtKB, UniProtKB]; TMIGD1 Inhibited Abdominal Adhesion Formation by Alleviating Oxidative Stress in the Mitochondria of Peritoneal Mesothelial Cells. Publication Status: Online-Only, [RefSeq, PubMed]; The cell adhesion molecule TMIGD1 binds to moesin and regulates tubulin acetylation and cell migration. Publication Status: Online-Only, [RefSeq, PubMed]; Transmembrane and Immunoglobulin Domain Containing 1, a Putative Tumor Suppressor, Induces G2/M Cell Cycle Checkpoint Arrest in Colon Cancer Cells., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8R202", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0060574 intestinal epithelial cell maturation;GO:0090559 regulation of membrane permeability;GO:0007584 response to nutrient;GO:0016477 cell migration;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D7L8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6R5P0-1", "uniprot_id": [ { "id": "TLR11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6R5P0", "type": "external" } ], "mass": 105873.0, "length": 926, "protein_name": "Toll-like receptor 11", "gene_name": "Tlr11", "organism": "Mouse", "refseq_name": "toll-like receptor 11", "refseq_ac": [ { "id": "NP_991388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991388", "type": "external" } ], "gene_names_uniprotkb": "Tlr11; Gm287; Tlr12", "gene_names_refseq": "Gm287; Tlr11", "protein_names_uniprotkb": "Toll-like receptor 11; Toll-like receptor 12", "protein_names_refseq": "toll-like receptor 11; toll-like receptor 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:239081)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14993594;15860593;17000122;20865800;21750661;25428506;26859749;29017773;30084848;32453782;34428180", "class_list": "", "function": "Mechanisms of interaction with flagellin and profilin Publication Status: Online-Only, [RefSeq, PubMed]; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response., [UniProtKB, UniProtKB]; Study demonstrates the important role of GRA15 and GRA24 in activating the innate immune response in hosts lacking TLR11. Publication Status: Online-Only, [RefSeq, PubMed]; TLR11 or TLR12 silencing reduces parasite burden and increases IFN-gamma, but reduces IL-4, production indicating that TLR11 and TLR12 play a pro-leishmanial role., [RefSeq, PubMed]; The immunogenicity of Toxoplasma gondii profilin was entirely dependent on both TLR11 recognition and signaling through the adaptor myeloid differentiation factor 88 (MyD88)., [RefSeq, PubMed]; Toxoplasma gondii profilin activates dendritic cells through TLR11 and is the first chemically defined ligand for this TLR; TLR11 is required in vivo for parasite-induced IL-12 production and optimal resistance to infection, [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0009617 response to bacterium;GO:0002224 toll-like receptor signaling pathway;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6R5P0-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6UJB9-1", "uniprot_id": [ { "id": "TM270_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6UJB9", "type": "external" } ], "mass": 29547.0, "length": 264, "protein_name": "Transmembrane protein 270", "gene_name": "Tmem270", "organism": "Mouse", "refseq_name": "transmembrane protein 270 isoform b", "refseq_ac": [ { "id": "NP_083957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083957", "type": "external" } ], "gene_names_uniprotkb": "Tmem270; Wbscr28", "gene_names_refseq": "1700111I05Rik; Tmem270; Wbscr28", "protein_names_uniprotkb": "Transmembrane protein 270", "protein_names_refseq": "Williams-Beuren syndrome chromosome region 28; Williams-Beuren syndrome critical region 28; transmembrane protein 270 isoform b; williams-Beuren syndrome chromosomal region 28 protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:76629)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14656967;18398435", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D9B5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6UJB9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNI2-1", "uniprot_id": [ { "id": "TM59L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TNI2", "type": "external" } ], "mass": 37661.0, "length": 337, "protein_name": "Transmembrane protein 59-like", "gene_name": "Tmem59l", "organism": "Mouse", "refseq_name": "transmembrane protein 59-like isoform 1 precursor", "refseq_ac": [ { "id": "NP_892036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_892036", "type": "external" } ], "gene_names_uniprotkb": "Tmem59l; Bsmap", "gene_names_refseq": "5330410G16Rik; Tmem59l", "protein_names_uniprotkb": "Transmembrane protein 59-like; Brain-specific membrane-anchored protein", "protein_names_refseq": "brain-specific membrane-anchored protein; transmembrane protein 59-like isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:67937)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10.1101/2023.09.13.557529", "class_list": "", "function": "Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0001658 branching involved in ureteric bud morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TNI2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQ65-1", "uniprot_id": [ { "id": "TMC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQ65", "type": "external" } ], "mass": 77367.0, "length": 694, "protein_name": "Voltage-gated chloride channel TMC4", "gene_name": "Tmc4", "organism": "Mouse", "refseq_name": "voltage-gated chloride channel TMC4", "refseq_ac": [ { "id": "NP_861541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861541", "type": "external" } ], "gene_names_uniprotkb": "Tmc4", "gene_names_refseq": "Tmc4", "protein_names_uniprotkb": "Voltage-gated chloride channel TMC4; Transmembrane channel-like protein 4", "protein_names_refseq": "transmembrane channel-like protein 4; voltage-gated chloride channel TMC4", "tax_id": 10090, "disease": "", "pathway": " (mmu:353499)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12812529;12906855;21750661;30084848;34429071;37947260", "class_list": "", "function": "Mouse TMC4 is involved in the detection of chloride taste of salts., [RefSeq, PubMed]; TMC4 is a novel chloride channel involved in high-concentration salt taste sensation. Publication Status: Online-Only, [RefSeq, PubMed]; Voltage-gated chloride channel involved in high-concentration salt taste sensation (PubMed:34429071). Depolarization induced by high NaCl concentration may trigger the activation of TMC4-mediated chloride influx into taste bud cells, helping the return to resting potential (PubMed:34429071). Also allows permeation of organic anions including gluconate, but their current amplitudes at positive potentials are less than that of chloride (PubMed:34429071). Involved in pH and temperature-dependent modulation of salty taste (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TMJ5;Q7TN62;Q8C7J5;Q8CGE2;Q8R1X9", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005247 voltage-gated chloride channel activity;GO:0008381 mechanosensitive monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050914 sensory perception of salty taste", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7TQ65-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH01-1", "uniprot_id": [ { "id": "SL9D1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH01", "type": "external" } ], "mass": 75903.0, "length": 678, "protein_name": "Solute carrier family 9 member D1", "gene_name": "Slc9d1; Tmco3", "organism": "Mouse", "refseq_name": "solute carrier family 9 member D1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_758486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758486", "type": "external" } ], "gene_names_uniprotkb": "Slc9d1; Tmco3; Tmco3", "gene_names_refseq": "B230339H12Rik; Slc9d1; Tmco3", "protein_names_uniprotkb": "Solute carrier family 9 member D1; Transmembrane and coiled-coil domain-containing protein 3", "protein_names_refseq": "solute carrier family 9 member D1 isoform 1 precursor; transmembrane and coiled-coil domain-containing protein 3; transmembrane and coiled-coil domains 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:234076)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;25605945;31219806;34418053;34428180;37554015", "class_list": "", "function": "Probable Na(+):H(+) or K(+):H(+) antiporter (Probable). Upon IGF1-dependent phosphorylation, facilitates the membrane translocation and activation of AKT1 (By similarity)., [UniProtKB, PubMed, UniProtKB]; TMCO3, a Putative K[+] :Proton Antiporter at the Golgi Apparatus, Is Important for Longitudinal Growth in Mice and Humans., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFX1;Q7TMT5;Q8BGL4;Q8R303", "ec_number_list": [], "go_molecular_function": "GO:0015386 potassium:proton antiporter activity;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BH01-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BIK6-1", "uniprot_id": [ { "id": "TMPS7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BIK6", "type": "external" } ], "mass": 92590.0, "length": 829, "protein_name": "Transmembrane protease serine 7", "gene_name": "Tmprss7", "organism": "Mouse", "refseq_name": "transmembrane protease serine 7", "refseq_ac": [ { "id": "NP_766043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766043", "type": "external" } ], "gene_names_uniprotkb": "Tmprss7", "gene_names_refseq": "B230219I23Rik; Gm1748; Tmprss7", "protein_names_uniprotkb": "Transmembrane protease serine 7; 3.4.21.-; Matriptase-3", "protein_names_refseq": "matriptase-3; transmembrane protease serine 7; transmembrane protease, serine 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:208171)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15853774", "class_list": "", "function": "Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QME7;Q4PPC3", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BIK6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BKV0-1", "uniprot_id": [ { "id": "TICN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BKV0", "type": "external" } ], "mass": 49098.0, "length": 436, "protein_name": "Testican-3", "gene_name": "Spock3", "organism": "Mouse", "refseq_name": "testican-3 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001239549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239549", "type": "external" } ], "gene_names_uniprotkb": "Spock3", "gene_names_refseq": "2900045C01Rik; Spock3; mKIAA4039", "protein_names_uniprotkb": "Testican-3; SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3", "protein_names_refseq": "testican-3 isoform 1 precursor; testican-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:72902); (R-MMU-1592389)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23418755;25138526", "class_list": "glycogene", "function": "May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion (By similarity)., [UniProtKB]; The expression of testican-3 in adult mice is restricted to the brain and located diffusely within the extracellular matrix., [RefSeq, PubMed]; These results demonstrate that Spock3 plays an important role in the formation or maintenance of major neuronal structures in the brain., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 22, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9ER59", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005539 glycosaminoglycan binding;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "GO:0010951 negative regulation of endopeptidase activity;GO:0010810 regulation of cell-substrate adhesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BKV0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BUZ3-1", "uniprot_id": [ { "id": "TIGD4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BUZ3", "type": "external" } ], "mass": 57472.0, "length": 513, "protein_name": "Tigger transposable element-derived protein 4", "gene_name": "Tigd4", "organism": "Mouse", "refseq_name": "tigger transposable element-derived protein 4", "refseq_ac": [ { "id": "NP_997161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997161", "type": "external" } ], "gene_names_uniprotkb": "Tigd4", "gene_names_refseq": "C130063O11Rik; Gm418; Tigd4", "protein_names_uniprotkb": "Tigger transposable element-derived protein 4", "protein_names_refseq": "tigger transposable element-derived protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:403175)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BUZ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BXZ1-1", "uniprot_id": [ { "id": "TMX3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BXZ1", "type": "external" } ], "mass": 51848.0, "length": 456, "protein_name": "Protein disulfide-isomerase TMX3", "gene_name": "Tmx3", "organism": "Mouse", "refseq_name": "protein disulfide-isomerase TMX3 precursor", "refseq_ac": [ { "id": "NP_938037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_938037", "type": "external" } ], "gene_names_uniprotkb": "Tmx3; Kiaa1830; Txndc10", "gene_names_refseq": "6430411B10Rik; A730024F05Rik; Tmx3; Txndc10; mKIAA1830", "protein_names_uniprotkb": "Protein disulfide-isomerase TMX3; 5.3.4.1; Thioredoxin domain-containing protein 10; Thioredoxin-related transmembrane protein 3", "protein_names_refseq": "protein disulfide-isomerase TMX3 precursor; protein disulfide-isomerase TMX3; thioredoxin domain containing 10; thioredoxin domain-containing protein 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:67988); (R-MMU-114608)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;26740625;30084848;30899004;31219806;34428180", "class_list": "", "function": "Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 8851, "biomarker_type": "", "glycan_count": 12, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3US84;Q6PGA1;Q6ZPH5;Q8BZB8", "ec_number_list": [ { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0015035 protein-disulfide reductase activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0009986 cell surface;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q8BXZ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZB3-1", "uniprot_id": [ { "id": "TM266_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZB3", "type": "external" } ], "mass": 58897.0, "length": 538, "protein_name": "Transmembrane protein 266", "gene_name": "Tmem266", "organism": "Mouse", "refseq_name": "transmembrane protein 266 isoform 1", "refseq_ac": [ { "id": "NP_766511", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766511", "type": "external" } ], "gene_names_uniprotkb": "Tmem266", "gene_names_refseq": "9630029F15; HVRP1; Tmem266", "protein_names_uniprotkb": "Transmembrane protein 266", "protein_names_refseq": "Hv1 related protein 1; transmembrane protein 266 isoform 1; transmembrane protein C15orf27 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:244886)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22517741;22645316;25165868;35574701;40885482", "class_list": "", "function": "Results identified HVRP1, a voltage sensing domains-containing protein primarily expressed in the central nervous system with high expression in cerebellar tissues particularly in the granule layer. Publication Status: Online-Only, [RefSeq, PubMed]; Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum. Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear. Undergoes both rapid and slow structural rearrangements in response to changes in voltage. Contains a zinc-binding site that can regulate the slow conformational transition., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B1B1B3;Q6NVG3", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BZB3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C013-1", "uniprot_id": [ { "id": "TPBGL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C013", "type": "external" } ], "mass": 41085.0, "length": 384, "protein_name": "Trophoblast glycoprotein-like", "gene_name": "Tpbgl", "organism": "Mouse", "refseq_name": "trophoblast glycoprotein-like precursor", "refseq_ac": [ { "id": "NP_001182458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182458", "type": "external" } ], "gene_names_uniprotkb": "Tpbgl; Gm4980", "gene_names_refseq": "EG245190; Gm4980; Tpbgl", "protein_names_uniprotkb": "Trophoblast glycoprotein-like", "protein_names_refseq": "trophoblast glycoprotein-like precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:100503386)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8C013-1", "record_type": "protein", "filter_code": "0000000.1000001.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGV2-1", "uniprot_id": [ { "id": "TPH2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CGV2", "type": "external" } ], "mass": 55859.0, "length": 488, "protein_name": "Tryptophan 5-hydroxylase 2", "gene_name": "Tph2", "organism": "Mouse", "refseq_name": "tryptophan 5-hydroxylase 2", "refseq_ac": [ { "id": "NP_775567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775567", "type": "external" } ], "gene_names_uniprotkb": "Tph2; Ntph", "gene_names_refseq": "Ntph; Tph2", "protein_names_uniprotkb": "Tryptophan 5-hydroxylase 2; 1.14.16.4; Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2", "protein_names_refseq": "neuronal tryptophan hydroxylase; tryptophan 5-hydroxylase 2; tryptophan 5-monooxygenase 2", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); sleep apnea (Disease Ontology:DOID:0050847); autism spectrum disorder (Disease Ontology:DOID:0060041); traumatic brain injury (Disease Ontology:DOID:0081292); hypertension (Disease Ontology:DOID:10763); autistic disorder (Disease Ontology:DOID:12849); premature ejaculation (Disease Ontology:DOID:13709); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); melancholic depression (Disease Ontology:DOID:1595); depressive disorder (Disease Ontology:DOID:1596); cystitis (Disease Ontology:DOID:1679); anxiety disorder (Disease Ontology:DOID:2030); post-traumatic stress disorder (Disease Ontology:DOID:2055); psychotic disorder (Disease Ontology:DOID:2468); bipolar disorder (Disease Ontology:DOID:3312); panic disorder (Disease Ontology:DOID:594); acute stress disorder (Disease Ontology:DOID:6088); premenstrual tension (Disease Ontology:DOID:727); subacute delirium (Disease Ontology:DOID:8645); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:216343); (R-MMU-209931)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12511643;39695187", "class_list": "", "function": "A second tryptophan hydroxylase isoform detected in the brain, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VBT4", "ec_number_list": [ { "id": "1.14.16.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.16.4", "type": "external" } ], "go_molecular_function": "GO:0004510 tryptophan 5-monooxygenase activity;GO:0005506 iron ion binding", "go_cellular_component": "GO:0030424 axon;GO:0043025 neuronal cell body;GO:0043005 neuron projection", "go_biological_process": "GO:0006587 serotonin biosynthetic process from tryptophan", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CGV2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K174-1", "uniprot_id": [ { "id": "TMM60_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K174", "type": "external" } ], "mass": 15518.0, "length": 133, "protein_name": "Transmembrane protein 60", "gene_name": "Tmem60", "organism": "Mouse", "refseq_name": "transmembrane protein 60", "refseq_ac": [ { "id": "NP_808269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808269", "type": "external" } ], "gene_names_uniprotkb": "Tmem60", "gene_names_refseq": "Tmem60", "protein_names_uniprotkb": "Transmembrane protein 60", "protein_names_refseq": "transmembrane protein 60", "tax_id": 10090, "disease": "", "pathway": " (mmu:212090)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BRZ0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8K174-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K558-1", "uniprot_id": [ { "id": "TRML1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K558", "type": "external" } ], "mass": 33522.0, "length": 317, "protein_name": "Trem-like transcript 1 protein", "gene_name": "Treml1", "organism": "Mouse", "refseq_name": "trem-like transcript 1 protein isoform 2 precursor", "refseq_ac": [ { "id": "NP_001276380", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276380", "type": "external" } ], "gene_names_uniprotkb": "Treml1; Tlt1", "gene_names_refseq": "5430401J17Rik; TLT-1; Treml1", "protein_names_uniprotkb": "Trem-like transcript 1 protein; TLT-1; Triggering receptor expressed on myeloid cells-like protein 1", "protein_names_refseq": "trem-like transcript 1 protein isoform 2 precursor; trem-like transcript 1 protein; triggering receptor expressed on myeloid cells-like 1c; triggering receptor expressed on myeloid cells-like 1d; triggering receptor expressed on myeloid cells-like 1e; triggering receptor expressed on myeloid cells-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71326); (R-MMU-198933)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "12393607;15100151;15128762;16505478;17242355;19436112;21183079;30282800;31713591;36961438;37766406", "class_list": "", "function": "A soluble fragment of the TLT-1 extracellular domain is found in serum of humans and mice and that an isoform of similar mass is released from platelets following activation with thrombin., [RefSeq, PubMed]; Cell surface receptor that may play a role in the innate and adaptive immune response., [UniProtKB, PubMed]; Decreased level of TREM like Transcript 1 (TLT-1) is associated with prematurity and promotes the in-utero inflammatory response to maternal lipopolysaccharide (LPS) exposure., [RefSeq, PubMed]; Expressed exclusively in platelets and megakaryocytes; expression is up-regulated upon platelet activation; is prepackaged into both MK and platelet alpha-granules; may regulate granule construction or dispersal, [RefSeq, PubMed]; Findings suggest that TLT-1 uses fibrinogen to govern the transition between inflammation and hemostasis and facilitate controlled leukocyte transmigration during the progression of ARDS., [RefSeq, PubMed]; High levels in atherosclerotic apoE-/- mice, [RefSeq, PubMed]; Initial characterization of TREM-like transcript (TLT)-1; results indicate it is likely that TLT-1 regulates the signaling of the TREM family receptors, [RefSeq, PubMed]; Soluble TREM-like Transcript-1 Acts as a Damage-Associated Molecular Pattern through the TLR4/MD2 Pathway Contributing to Immune Dysregulation during Sepsis., [RefSeq, PubMed]; TLT-1 plays a protective role during inflammation by dampening the inflammatory response and facilitating platelet aggregation at sites of vascular injury, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RRH0;Q9D3N6", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016607 nuclear speck", "go_biological_process": "GO:0007165 signal transduction;GO:0019722 calcium-mediated signaling;GO:0030168 platelet activation;GO:0009968 negative regulation of signal transduction;GO:0042060 wound healing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8K558-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VC26-1", "uniprot_id": [ { "id": "TLCD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VC26", "type": "external" } ], "mass": 34139.0, "length": 310, "protein_name": "TLC domain-containing protein 2", "gene_name": "Tlcd2", "organism": "Mouse", "refseq_name": "TLC domain-containing protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001278085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278085", "type": "external" } ], "gene_names_uniprotkb": "Tlcd2", "gene_names_refseq": "Tlcd2", "protein_names_uniprotkb": "TLC domain-containing protein 2", "protein_names_refseq": "TLC domain-containing protein 2 isoform 2; TLC domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:380712)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "Regulates the composition and fluidity of the plasma membrane (By similarity). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (By similarity). Does not appear to have any effect on LCPUFA synthesis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D837", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007009 plasma membrane organization;GO:0055091 phospholipid homeostasis;GO:0071709 membrane assembly;GO:0097035 regulation of membrane lipid distribution", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VC26-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XB0-1", "uniprot_id": [ { "id": "TREX1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91XB0", "type": "external" } ], "mass": 33675.0, "length": 314, "protein_name": "Three-prime repair exonuclease 1", "gene_name": "Trex1", "organism": "Mouse", "refseq_name": "three-prime repair exonuclease 1", "refseq_ac": [ { "id": "NP_001012236", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012236", "type": "external" } ], "gene_names_uniprotkb": "Trex1", "gene_names_refseq": "Trex1", "protein_names_uniprotkb": "Three-prime repair exonuclease 1; 3'-5' exonuclease TREX1; 3.1.11.2", "protein_names_refseq": "3'-5' exonuclease TREX1; DNase III; three prime exonuclease 1; three-prime repair exonuclease 1; trophoblast expressed 1", "tax_id": 10090, "disease": "cutaneous lupus erythematosus (Disease Ontology:DOID:0050169); Aicardi-Goutieres syndrome (Disease Ontology:DOID:0050629); Chilblain lupus (Disease Ontology:DOID:0060386); retinal vasculopathy with cerebral leukodystrophy (Disease Ontology:DOID:0111567); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:22040)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10391904;11279105;15254239;17293595;17355961;18045533;18724932;18780819;19144319;22071149;23993650;24218451;28297665;33606975;39254994", "class_list": "", "function": "CGAS activation in classical dendritic cells causes autoimmunity in TREX1-deficient mice., [RefSeq, PubMed]; Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini (PubMed:10391904, PubMed:11279105, PubMed:15254239, PubMed:17293595, PubMed:17355961, PubMed:18780819). Prevents cell-intrinsic initiation of autoimmunity (PubMed:18724932, PubMed:24218451). Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements (PubMed:18724932). Plays a key role in degradation of DNA fragments at cytosolic micronuclei arising from genome instability: its association with the endoplasmic reticulum membrane directs TREX1 to ruptured micronuclei, leading to micronuclear DNA degradation (By similarity). Micronuclear DNA degradation is required to limit CGAS activation and subsequent inflammation (By similarity). Unless degraded, these DNA fragments accumulate in the cytosol and activate the cGAS-STING innate immune signaling, leading to the production of type I interferon (PubMed:18724932). Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates (PubMed:18045533). Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light (PubMed:23993650). During GZMA-mediated cell death, contributes to DNA damage in concert with NME1 (By similarity). NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Trex1(-/-) mice exhibit a dramatically reduced survival and develop inflammatory myocarditis leading to progressive, often dilated, cardiomyopathy and circulatory failure, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAD7;Q9D6W2;Q9R1B0", "ec_number_list": [], "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0008296 3'-5'-DNA exonuclease activity;GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0071357 cellular response to type I interferon;GO:0043457 regulation of cellular respiration;GO:0002637 regulation of immunoglobulin production;GO:0002253 activation of immune response;GO:0002457 T cell antigen processing and presentation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q91XB0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQN3-1", "uniprot_id": [ { "id": "TOM6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQN3", "type": "external" } ], "mass": 7865.0, "length": 74, "protein_name": "Mitochondrial import receptor subunit TOM6 homolog", "gene_name": "Tomm6", "organism": "Mouse", "refseq_name": "mitochondrial import receptor subunit TOM6 homolog", "refseq_ac": [ { "id": "NP_001158201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158201", "type": "external" } ], "gene_names_uniprotkb": "Tomm6; Obtp; Tom6", "gene_names_refseq": "1110002E23Rik; Tomm6", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM6 homolog; Overexpressed breast tumor protein homolog; Translocase of outer membrane 6 kDa subunit homolog", "protein_names_refseq": "mitochondrial import receptor subunit TOM6 homolog; overexpressed breast tumor protein homolog; translocase of outer membrane 6 kDa subunit homolog; translocase of outer mitochondrial membrane 6 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66119); (R-MMU-5205685)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "34428180;37828378", "class_list": "", "function": "Component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005742 mitochondrial outer membrane translocase complex", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CQN3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR23-1", "uniprot_id": [ { "id": "TMEM9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR23", "type": "external" } ], "mass": 20633.0, "length": 183, "protein_name": "Proton-transporting V-type ATPase complex assembly regulator TMEM9", "gene_name": "Tmem9", "organism": "Mouse", "refseq_name": "proton-transporting V-type ATPase complex assembly regulator TMEM9 precursor", "refseq_ac": [ { "id": "NP_001153617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153617", "type": "external" } ], "gene_names_uniprotkb": "Tmem9", "gene_names_refseq": "1500015G18Rik; Tmem9", "protein_names_uniprotkb": "Proton-transporting V-type ATPase complex assembly regulator TMEM9; Protein TMEM9; Transmembrane protein 9; v-ATPase assembly regulator TMEM9", "protein_names_refseq": "proton-transporting V-type ATPase complex assembly regulator TMEM9 precursor; proton-transporting V-type ATPase complex assembly regulator TMEM9; v-ATPase assembly regulator TMEM9", "tax_id": 10090, "disease": "", "pathway": " (mmu:66241)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;26495903;28011936;30374053;30899004;31599954;32380568;34428180;37828378", "class_list": "", "function": "TMEM9-v-ATPase Activates Wnt/beta-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis., [RefSeq, PubMed]; Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking (By similarity). By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation (By similarity). TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC (PubMed:30374053, PubMed:32380568). In the liver, involved in hepatic regeneration (PubMed:32380568)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3U459", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0015630 microtubule cytoskeleton;GO:0045171 intercellular bridge;GO:0005770 late endosome", "go_biological_process": "GO:0015031 protein transport;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0048388 endosomal lumen acidification;GO:0007042 lysosomal lumen acidification;GO:0042176 regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9CR23-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CRB6-1", "uniprot_id": [ { "id": "TPPP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CRB6", "type": "external" } ], "mass": 18965.0, "length": 176, "protein_name": "Tubulin polymerization-promoting protein family member 3", "gene_name": "Tppp3", "organism": "Mouse", "refseq_name": "tubulin polymerization-promoting protein family member 3", "refseq_ac": [ { "id": "NP_080757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080757", "type": "external" } ], "gene_names_uniprotkb": "Tppp3", "gene_names_refseq": "2700055K07Rik; CGI-38; Ceacam9; Tppp3; mmCGM8", "protein_names_uniprotkb": "Tubulin polymerization-promoting protein family member 3", "protein_names_refseq": "tubulin polymerization-promoting protein family member 3", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:67971)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19235716;20571904;29901777;30667362;32848054;37507081;40021952", "class_list": "", "function": "Findings suggested that the TPPP3 gene played an important role in tumorigenesis and metastasis, and it could potentially become a novel target for cancer therapy, [RefSeq, PubMed]; Onset of Tppp3 expression in joints coincides with cavitation, representing a molecular marker that can be used to indicate this stage in joint transition in joint differentiation, [RefSeq, PubMed]; Regulator of microtubule dynamic that has microtubule bundling activity (By similarity). Required for embryo implantation; possibly by regulating beta-catenin (PubMed:29901777). Also required for decidualization via regulation of beta-catenin (PubMed:30667362)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUZ0", "ec_number_list": [], "go_molecular_function": "GO:0015631 tubulin binding", "go_cellular_component": "GO:0005874 microtubule;GO:0048471 perinuclear region of cytoplasm;GO:0097427 microtubule bundle", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0007566 embryo implantation;GO:0046697 decidualization;GO:0001578 microtubule bundle formation;GO:0032273 positive regulation of protein polymerization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CRB6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2R4-1", "uniprot_id": [ { "id": "TMD11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2R4", "type": "external" } ], "mass": 24842.0, "length": 215, "protein_name": "Transmembrane emp24 domain-containing protein 11", "gene_name": "Tmed11", "organism": "Mouse", "refseq_name": "transmembrane emp24 domain-containing protein 11 precursor", "refseq_ac": [ { "id": "NP_080385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080385", "type": "external" } ], "gene_names_uniprotkb": "Tmed11", "gene_names_refseq": "1810008K16Rik; Tmed11", "protein_names_uniprotkb": "Transmembrane emp24 domain-containing protein 11; GP25L; Glycoprotein 25L; p24 family protein alpha-1; p24alpha1", "protein_names_refseq": "GP25L; glycoprotein 25L; p24 family protein alpha-1; p24alpha1; transmembrane emp24 domain-containing protein 11 precursor; transmembrane emp24 domain-containing protein 11; transmembrane emp24 protein transport domain containing", "tax_id": 10090, "disease": "", "pathway": " (mmu:67366)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "36210013", "class_list": "", "function": "Part of a complex whose function is to bind Ca(2+) to the ER membrane and thereby regulate the retention of ER resident proteins., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D2R4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D5K1-1", "uniprot_id": [ { "id": "TMM81_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D5K1", "type": "external" } ], "mass": 28748.0, "length": 259, "protein_name": "Transmembrane protein 81", "gene_name": "Tmem81", "organism": "Mouse", "refseq_name": "transmembrane protein 81 precursor", "refseq_ac": [ { "id": "NP_083301", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083301", "type": "external" } ], "gene_names_uniprotkb": "Tmem81", "gene_names_refseq": "4930429O20Rik; Tmem81", "protein_names_uniprotkb": "Transmembrane protein 81", "protein_names_refseq": "transmembrane protein 81 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:74626)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Essential fertilization factor required for male fertility. Part of a conserved trimeric sperm complex with the essential fertilization factors IZUMO1 and SPACA6 which bridges sperm and oocyte membranes during fertilization by binding to IZUMO1R/JUNO on the oocyte., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q4VBF9", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0035036 sperm-egg recognition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D5K1-1", "record_type": "protein", "filter_code": "0000000.1000001.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D880-1", "uniprot_id": [ { "id": "TIM50_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D880", "type": "external" } ], "mass": 39776.0, "length": 353, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM50", "gene_name": "Timm50", "organism": "Mouse", "refseq_name": "mitochondrial import inner membrane translocase subunit TIM50 precursor", "refseq_ac": [ { "id": "NP_079892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079892", "type": "external" } ], "gene_names_uniprotkb": "Timm50; Tim50", "gene_names_refseq": "2810403L02Rik; TIM50L; Timm50", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM50", "protein_names_refseq": "mitochondrial import inner membrane translocase subunit TIM50 precursor; mitochondrial import inner membrane translocase subunit TIM50; translocase of inner mitochondrial membrane 50 homolog", "tax_id": 10090, "disease": "3-methylglutaconic aciduria type 9 (Disease Ontology:DOID:0070002); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:66525)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15044455;22645316;25428506;25605945;26495903;28432072;34428180;36210013", "class_list": "", "function": "Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo., [UniProtKB, UniProtKB]; TIM50 deficiency increased heart and cardiomyocyte size with more severe cardiac fibrosis compared with wild-type littermates. In cardiomyocyte-specific TIM50 transgenic mice, the hypertrophic and fibrotic phenotypes were all alleviated. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3A7;Q91Z17", "ec_number_list": [], "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0005134 interleukin-2 receptor binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001836 release of cytochrome c from mitochondria;GO:0006470 protein dephosphorylation;GO:0030150 protein import into mitochondrial matrix;GO:0007006 mitochondrial membrane organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D880-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8N3-1", "uniprot_id": [ { "id": "TM86A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8N3", "type": "external" } ], "mass": 26273.0, "length": 241, "protein_name": "Lysoplasmalogenase TMEM86A", "gene_name": "Tmem86a", "organism": "Mouse", "refseq_name": "lysoplasmalogenase TMEM86A", "refseq_ac": [ { "id": "NP_080712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080712", "type": "external" } ], "gene_names_uniprotkb": "Tmem86a", "gene_names_refseq": "1810054O13Rik; Tmem86a", "protein_names_uniprotkb": "Lysoplasmalogenase TMEM86A; 3.3.2.2; Transmembrane protein 86A", "protein_names_refseq": "lysoplasmalogenase TMEM86A; lysoplasmalogenase-like protein TMEM86A", "tax_id": 10090, "disease": "", "pathway": " (mmu:67893)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "31219806;34428180;35835749;36210013;36592658", "class_list": "", "function": "Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen homeostasis and protein kinase A-dependent energy metabolism. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the hydrolysis of the vinyl ether bond of choline or ethanolamine lysoplasmalogens, forming fatty aldehyde and glycerophosphocholine or glycerophosphoethanolamine, respectively and is specific for the sn-2-deacylated (lyso) form of plasmalogen (PubMed:35835749, PubMed:36592658). Plays an important role in lysoplasmalogen metabolism in the adipocyte tissue and macrophages (PubMed:35835749, PubMed:36592658)., [UniProtKB, PubMed, PubMed]; Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C6I3", "ec_number_list": [ { "id": "3.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.2", "type": "external" } ], "go_molecular_function": "GO:0047408 alkenylglycerophosphocholine hydrolase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D8N3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBI0-1", "uniprot_id": [ { "id": "TMPS6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBI0", "type": "external" } ], "mass": 90978.0, "length": 811, "protein_name": "Transmembrane protease serine 6", "gene_name": "Tmprss6", "organism": "Mouse", "refseq_name": "transmembrane protease serine 6 isoform 1", "refseq_ac": [ { "id": "NP_082178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082178", "type": "external" } ], "gene_names_uniprotkb": "Tmprss6", "gene_names_refseq": "1300008A22Rik; Tmprss6", "protein_names_uniprotkb": "Transmembrane protease serine 6; 3.4.21.-; Matriptase-2", "protein_names_refseq": "matriptase 2; transmembrane protease serine 6 isoform 1; transmembrane protease, serine 6; type II transmembrane serine protease 6", "tax_id": 10090, "disease": "microcytic anemia (Disease Ontology:DOID:11252)", "pathway": " (mmu:71753); (R-MMU-1442490); (R-MMU-1474228)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12744720;12784999;17981570;18451267;21750661;34428180;38218852", "class_list": "", "function": "Findings show that TMPRSS6 is an essential component of a pathway that detects iron deficiency and blocks Hamp transcription, permitting enhanced dietary iron absorption, [RefSeq, PubMed]; Identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissues, [RefSeq, PubMed]; Identification, structural features, enzymology, expression pattern and potential roles of TMPRSS6 [review] Review article Publication Status: Online-Only, [RefSeq, PubMed]; Membrane-bound serine protease (PubMed:18451267). Through the cleavage of cell surface HJV, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis (PubMed:18451267)., [UniProtKB, PubMed]; Transmembrane serine protease 6, a novel target for inhibition of neuronal tumor growth. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A8W478;A8W479;Q3KN88;Q6PF94", "ec_number_list": [ { "id": "3.4.24.80", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.80", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006508 proteolysis;GO:0016485 protein processing;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DBI0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBS1-1", "uniprot_id": [ { "id": "TMM43_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBS1", "type": "external" } ], "mass": 44783.0, "length": 400, "protein_name": "Transmembrane protein 43", "gene_name": "Tmem43", "organism": "Mouse", "refseq_name": "transmembrane protein 43", "refseq_ac": [ { "id": "NP_083042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083042", "type": "external" } ], "gene_names_uniprotkb": "Tmem43", "gene_names_refseq": "1200015A22Rik; LUMA; Tmem43", "protein_names_uniprotkb": "Transmembrane protein 43; Protein LUMA", "protein_names_refseq": "transmembrane protein 43", "tax_id": 10090, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); autosomal dominant Emery-Dreifuss muscular dystrophy 7 (Disease Ontology:DOID:0070252); arrhythmogenic right ventricular dysplasia 5 (Disease Ontology:DOID:0110074); autosomal dominant auditory neuropathy 3 (Disease Ontology:DOID:0112373)", "pathway": " (mmu:74122)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11593002;18230648;25428506;29040414;29980933;30779550;31219806;33070193;34050020;34203471;34428180;36230956;37083466;37697676", "class_list": "", "function": "Haploinsufficiency of Tmem43 in cardiac myocytes activates the DNA damage response pathway leading to a late-onset senescence-associated pro-fibrotic cardiomyopathy., [RefSeq, PubMed]; Luma is dispensable for murine cardiac development and function, and that the Luma S358L mutation alone may not cause cardiomyopathy in mice., [RefSeq, PubMed]; May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (PubMed:18230648). Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10 (By similarity). Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing (PubMed:34050020)., [UniProtKB, UniProtKB, PubMed, PubMed]; Reduced expression of transmembrane protein 43 during cardiac hypertrophy leads to worsening heart failure in mice., [RefSeq, PubMed]; TMEM43 Protects against Sepsis-Induced Cardiac Injury via Inhibiting Ferroptosis in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; The TMEM43 S358L mutation affects cardiac, small intestine, and metabolic homeostasis in a knock-in mouse model., [RefSeq, PubMed]; The authors show that TMEM43-S358L mutation up-regulates NF-kappaB (nuclear factor kappaappa B)-TGFbeta (transforming growth factor beta 1) signal cascade during arrhythmogenic right ventricular dysplasia cardiac fibrosis in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005248 voltage-gated sodium channel activity;GO:0005249 voltage-gated potassium channel activity;GO:0022843 voltage-gated monoatomic cation channel activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0007613 memory;GO:0045087 innate immune response;GO:0006813 potassium ion transport;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9DBS1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ER62-1", "uniprot_id": [ { "id": "TNR22_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ER62", "type": "external" } ], "mass": 22375.0, "length": 198, "protein_name": "Tumor necrosis factor receptor superfamily member 22", "gene_name": "Tnfrsf22", "organism": "Mouse", "refseq_name": "tumor necrosis factor receptor superfamily member 22 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001298074", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298074", "type": "external" } ], "gene_names_uniprotkb": "Tnfrsf22; Dctrailr2; Tnfrh2; Tnfrsf1al2", "gene_names_refseq": "2810028K06Rik; C130035G06Rik; SOBa; Tnfrh2; Tnfrsf1al2; Tnfrsf22; mDcTrailr2", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 22; Decoy TRAIL receptor 2; TNF receptor family member SOBa; TNF receptor homolog 2; Tumor necrosis factor receptor p60 homolog 2", "protein_names_refseq": "TNF receptor family member SOBa; TNF receptor homolog 2; decoy TRAIL receptor 2; tumor necrosis factor receptor p60 homolog 2; tumor necrosis factor receptor superfamily member 22 isoform 2 precursor; tumor necrosis factor receptor superfamily, member 1a-like 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:79202)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;11063728;12466268;29973541", "class_list": "", "function": "Receptor for the cytotoxic ligand TNFSF10/TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. Protects cells against TRAIL mediated apoptosis possibly through ligand competition. Cannot induce the NF-kappa-B pathway., [UniProtKB, PubMed]; Transmembrane TNF, TNFR2 and TNFR1 (indirectly) are critical for preventing inflammation during BCG-induced pleurisy in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8VHB9;Q9CZA4", "ec_number_list": [], "go_molecular_function": "GO:0045569 TRAIL binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0036462 TRAIL-activated apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ER62-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYH9-1", "uniprot_id": [ { "id": "TNF14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYH9", "type": "external" } ], "mass": 26338.0, "length": 239, "protein_name": "Tumor necrosis factor ligand superfamily member 14", "gene_name": "Tnfsf14", "organism": "Mouse", "refseq_name": "tumor necrosis factor ligand superfamily member 14", "refseq_ac": [ { "id": "NP_062291", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062291", "type": "external" } ], "gene_names_uniprotkb": "Tnfsf14; Light", "gene_names_refseq": "HVEM-L; HVEML; LIGHT; LTg; Ly113; Tnfsf14; Tnlg1d", "protein_names_uniprotkb": "Tumor necrosis factor ligand superfamily member 14", "protein_names_refseq": "tumor necrosis factor ligand 1d; tumor necrosis factor ligand superfamily member 14", "tax_id": 10090, "disease": "IgA glomerulonephritis (Disease Ontology:DOID:2986)", "pathway": " (mmu:50930); (R-MMU-5668541); (R-MMU-5676594)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10700230;10894944;37108160;37408308;38255789", "class_list": "", "function": "Cytokine that binds to TNFRSF3/LTBR. Activates NFKB and stimulates the proliferation of T-cells. Acts as a ligand for TNFRSF14/HVEM. Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production (By similarity)., [UniProtKB, UniProtKB]; LIGHT/TNFSF14 Affects Adipose Tissue Phenotype. Publication Status: Online-Only, [RefSeq, PubMed]; LIGHT/TNFSF14 promotes CAR-T cell trafficking and cytotoxicity through reversing immunosuppressive tumor microenvironment., [RefSeq, PubMed]; Tumor Necrosis Factor Superfamily 14 (LIGHT) Restricts Neovascularization by Decreasing Circulating Endothelial Progenitor Cells and Function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q059Y9", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0002947 tumor necrosis factor receptor superfamily complex;GO:0140368 decoy receptor complex", "go_biological_process": "GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0010820 positive regulation of T cell chemotaxis;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0031295 T cell costimulation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9QYH9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0L0-1", "uniprot_id": [ { "id": "TPBG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0L0", "type": "external" } ], "mass": 46451.0, "length": 426, "protein_name": "Trophoblast glycoprotein", "gene_name": "Tpbg", "organism": "Mouse", "refseq_name": "trophoblast glycoprotein precursor", "refseq_ac": [ { "id": "NP_001158264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158264", "type": "external" } ], "gene_names_uniprotkb": "Tpbg; 5t4", "gene_names_refseq": "5T4; Tpbg; WAIF1", "protein_names_uniprotkb": "Trophoblast glycoprotein; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrophoblast glycoprotein; WAIF1; Wnt-activated inhibitory factor 1", "protein_names_refseq": "5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrophoblast glycoprotein; trophoblast glycoprotein precursor; wnt-activated inhibitory factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:21983)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10366710;11903056;14576347;15977177;16506198;19349973;30899004;31219806;37828378", "class_list": "", "function": "5T4 glycoprotein expression is associated with early differentiative events of embryonic stem cells, [RefSeq, PubMed]; A limited expression profile of 5T4 may contribute to the migration of actively cycling, undifferentiated epithelial progenitor cells during embryogenesis, [RefSeq, PubMed]; Because 5T4 is known to interact with actin cytoskeleton, these observations suggest that 5T4 is involved in the formation or maintenance of strata-specific dendritic ramification or synaptic connection of subsets of local interneurons., [RefSeq, PubMed]; Glycosylation and epitope mapping of the 5T4 glycoprotein oncofoetal antigen, [RefSeq, PubMed]; May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 12, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3UPI2;Q6PE98;Q8BQA4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043679 axon terminus", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0072659 protein localization to plasma membrane;GO:0090090 negative regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q9Z0L0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P86448-1", "uniprot_id": [ { "id": "TR43B_MOUSE", "url": "https://www.uniprot.org/uniprot/P86448", "type": "external" } ], "mass": 52238.0, "length": 445, "protein_name": "Tripartite motif-containing protein 43B", "gene_name": "Trim43b", "organism": "Mouse", "refseq_name": "tripartite motif-containing protein 43B", "refseq_ac": [ { "id": "NP_001164355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164355", "type": "external" } ], "gene_names_uniprotkb": "Trim43b", "gene_names_refseq": "EG666747; Gm8269; Trim43b", "protein_names_uniprotkb": "Tripartite motif-containing protein 43B", "protein_names_refseq": "tripartite motif-containing protein 43B", "tax_id": 10090, "disease": "", "pathway": " (mmu:666747)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19703589;21750661", "class_list": "", "function": "We describe the identification and characterization of Trim43a, Trim43b, and Trim43c genes, whose expression are restricted to preimplantation stages and peak at the 8-cell to morula stage, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0045087 innate immune response;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P86448-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54818-1", "uniprot_id": [ { "id": "TPD53_MOUSE", "url": "https://www.uniprot.org/uniprot/O54818", "type": "external" } ], "mass": 22515.0, "length": 204, "protein_name": "Tumor protein D53", "gene_name": "Tpd52l1", "organism": "Mouse", "refseq_name": "tumor protein D53 isoform 2", "refseq_ac": [ { "id": "NP_033439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033439", "type": "external" } ], "gene_names_uniprotkb": "Tpd52l1", "gene_names_refseq": "D53; Tpd52l1", "protein_names_uniprotkb": "Tumor protein D53; Tumor protein D52-like 1; mD53", "protein_names_refseq": "tumor protein D53 isoform 2; tumor protein D53", "tax_id": 10090, "disease": "", "pathway": " (mmu:21987); (R-MMU-432722)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;34428180;35822049;8812487", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0000086 G2/M transition of mitotic cell cycle;GO:2001235 positive regulation of apoptotic signaling pathway;GO:0043406 positive regulation of MAP kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O54818-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E5FYH1-1", "uniprot_id": [ { "id": "TOPZ1_MOUSE", "url": "https://www.uniprot.org/uniprot/E5FYH1", "type": "external" } ], "mass": 185487.0, "length": 1653, "protein_name": "Protein TOPAZ1", "gene_name": "Topaz1", "organism": "Mouse", "refseq_name": "protein TOPAZ1", "refseq_ac": [ { "id": "NP_001186665", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186665", "type": "external" } ], "gene_names_uniprotkb": "Topaz1; Gm9524", "gene_names_refseq": "671232; Gm9524; Topaz1", "protein_names_uniprotkb": "Protein TOPAZ1; Testis- and ovary-specific PAZ domain-containing protein 1", "protein_names_refseq": "protein TOPAZ1; testis and ovary-specific PAZ domain gene 1; testis- and ovary-specific PAZ domain-containing protein 1; topaz 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:671232)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22069478;26358182;34418053", "class_list": "", "function": "Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear., [UniProtKB, PubMed]; TOPAZ1, a germ cell specific factor, is essential for male meiotic progression., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0030154 cell differentiation;GO:0006915 apoptotic process;GO:0048137 spermatocyte division;GO:0140742 lncRNA transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E5FYH1-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41155-1", "uniprot_id": [ { "id": "TNFC_MOUSE", "url": "https://www.uniprot.org/uniprot/P41155", "type": "external" } ], "mass": 32329.0, "length": 306, "protein_name": "Lymphotoxin-beta", "gene_name": "Ltb", "organism": "Mouse", "refseq_name": "lymphotoxin-beta", "refseq_ac": [ { "id": "NP_032544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032544", "type": "external" } ], "gene_names_uniprotkb": "Ltb; Tnfc; Tnfsf3", "gene_names_refseq": "LTbeta; Ltb; Tnfc; Tnfsf3; Tnlg1c; p33", "protein_names_uniprotkb": "Lymphotoxin-beta; LT-beta; TNF-C; Tumor necrosis factor C; Tumor necrosis factor ligand superfamily member 3", "protein_names_refseq": "LT-beta; TNF-C; lymphotoxin-beta; tumor necrosis factor C; tumor necrosis factor ligand 1c; tumor necrosis factor ligand superfamily member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:16994); (R-MMU-5668541); (R-MMU-5676594)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11801660;14656967;21750661;26495903;26740625;7846035;7995944", "class_list": "", "function": "Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0002947 tumor necrosis factor receptor superfamily complex", "go_biological_process": "GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway;GO:0043588 skin development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P41155-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55013-1", "uniprot_id": [ { "id": "TPPC3_MOUSE", "url": "https://www.uniprot.org/uniprot/O55013", "type": "external" } ], "mass": 20302.0, "length": 180, "protein_name": "Trafficking protein particle complex subunit 3", "gene_name": "Trappc3", "organism": "Mouse", "refseq_name": "trafficking protein particle complex subunit 3", "refseq_ac": [ { "id": "NP_038746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038746", "type": "external" } ], "gene_names_uniprotkb": "Trappc3; Bet3", "gene_names_refseq": "1110058K12Rik; Bet3; Trappc3", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 3; BET3 homolog", "protein_names_refseq": "Bet3 homolog; trafficking protein particle complex subunit 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:27096); (R-MMU-204005); (R-MMU-8876198)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "15608655;16828797;17027922;19224205;19892989;20173027;25428506;25605945;27802388;30084848;30779550;31219806;34203471;34428180;36210013", "class_list": "", "function": "May play a role in vesicular transport from endoplasmic reticulum to Golgi., [UniProtKB]; The crystal structure of mouse Bet3p (bet3), a conserved TRAPP component, reveals a dimeric structure with hydrophobic channels, [RefSeq, PubMed]; Together our findings indicate that BET3 plays an important role in the organization of the TRAPP complexes in both mammalian cells and yeast., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0033106 cis-Golgi network membrane", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048208 COPII vesicle coating;GO:0006891 intra-Golgi vesicle-mediated transport;GO:0006901 vesicle coating;GO:0099022 vesicle tethering", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O55013-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04213-1", "uniprot_id": [ { "id": "TVB5_MOUSE", "url": "https://www.uniprot.org/uniprot/P04213", "type": "external" } ], "mass": 13349.0, "length": 122, "protein_name": "T-cell receptor beta chain V region C5", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "T-cell receptor beta chain V region C5", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "6092964", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042101 T cell receptor complex", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P04213-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09225-1", "uniprot_id": [ { "id": "TNFB_MOUSE", "url": "https://www.uniprot.org/uniprot/P09225", "type": "external" } ], "mass": 21999.0, "length": 202, "protein_name": "Lymphotoxin-alpha", "gene_name": "Lta", "organism": "Mouse", "refseq_name": "lymphotoxin-alpha precursor", "refseq_ac": [ { "id": "NP_034865", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034865", "type": "external" } ], "gene_names_uniprotkb": "Lta; Tnfb; Tnfsf1", "gene_names_refseq": "LT-[a]; LT-alpha; LT[a]; LTalpha; LT; Lta; Ltx; TNF-beta; TNFSF1; Tnfb; Tnfsf1b; Tnlg1e; hlb382", "protein_names_uniprotkb": "Lymphotoxin-alpha; LT-alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1", "protein_names_refseq": "TNF beta; lymphotoxin-alpha precursor; lymphotoxin-alpha; tumor necrosis factor ligand 1e; tumor necrosis factor ligand superfamily member 1", "tax_id": 10090, "disease": "sinusitis (Disease Ontology:DOID:0050127); chorioamnionitis (Disease Ontology:DOID:0050697); erythema nodosum (Disease Ontology:DOID:0080750); leprosy (Disease Ontology:DOID:1024); adult respiratory distress syndrome (Disease Ontology:DOID:11394); allergic disease (Disease Ontology:DOID:1205); Graves' disease (Disease Ontology:DOID:12361); Sjogren's syndrome (Disease Ontology:DOID:12894); typhoid fever (Disease Ontology:DOID:13258); pulmonary sarcoidosis (Disease Ontology:DOID:13406); endometrial cancer (Disease Ontology:DOID:1380); cystic fibrosis (Disease Ontology:DOID:1485); breast cancer (Disease Ontology:DOID:1612); cystitis (Disease Ontology:DOID:1679); melanoma (Disease Ontology:DOID:1909); hyperinsulinism (Disease Ontology:DOID:2018); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); high grade glioma (Disease Ontology:DOID:3070); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); cerebral infarction (Disease Ontology:DOID:3526); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); pustulosis of palm and sole (Disease Ontology:DOID:4398); myocardial infarction (Disease Ontology:DOID:5844); dermatitis herpetiformis (Disease Ontology:DOID:8505); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); psoriatic arthritis (Disease Ontology:DOID:9008); visceral leishmaniasis (Disease Ontology:DOID:9146); mucocutaneous leishmaniasis (Disease Ontology:DOID:9155); type 2 diabetes mellitus (Disease Ontology:DOID:9352); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:16992); (R-MMU-5668541); (R-MMU-5669034); (R-MMU-5676594)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "14656967;1700275;2884262;2885372;3147435;3490653;3588316;3684584", "class_list": "", "function": "Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 35, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0002947 tumor necrosis factor receptor superfamily complex", "go_biological_process": "GO:0060252 positive regulation of glial cell proliferation;GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P09225-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15306-1", "uniprot_id": [ { "id": "TRBM_MOUSE", "url": "https://www.uniprot.org/uniprot/P15306", "type": "external" } ], "mass": 61868.0, "length": 577, "protein_name": "Thrombomodulin", "gene_name": "Thbd", "organism": "Mouse", "refseq_name": "thrombomodulin precursor", "refseq_ac": [ { "id": "NP_033404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033404", "type": "external" } ], "gene_names_uniprotkb": "Thbd", "gene_names_refseq": "CD141; TM; Thbd", "protein_names_uniprotkb": "Thrombomodulin; Fetomodulin; TM", "protein_names_refseq": "fetomodulin; snoRNA MBII-339; thrombomodulin precursor", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); stroke (Disease Ontology:DOID:0051061); atypical hemolytic-uremic syndrome (Disease Ontology:DOID:0080301); thrombophilia due to thrombomodulin defect (Disease Ontology:DOID:0111908); brain small vessel disease (Disease Ontology:DOID:0112313); dermatomyositis (Disease Ontology:DOID:10223); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); disseminated intravascular coagulation (Disease Ontology:DOID:11247); adult respiratory distress syndrome (Disease Ontology:DOID:11394); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); familial combined hyperlipidemia (Disease Ontology:DOID:13809); hypothyroidism (Disease Ontology:DOID:1459); impotence (Disease Ontology:DOID:1875); thrombophilia (Disease Ontology:DOID:2452); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); familial Mediterranean fever (Disease Ontology:DOID:2987); acute kidney failure (Disease Ontology:DOID:3021); ischemia (Disease Ontology:DOID:326); coronary artery disease (Disease Ontology:DOID:3393); carotid artery thrombosis (Disease Ontology:DOID:3410); cerebral infarction (Disease Ontology:DOID:3526); lung non-small cell carcinoma (Disease Ontology:DOID:3908); liver disease (Disease Ontology:DOID:409); pulmonary hypertension (Disease Ontology:DOID:6432); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:21824); (R-MMU-202733); (R-MMU-9769739)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;19656770;2536925;2844823;31219806;36162255;37828378;38174561;38709159;7846065", "class_list": "glycogene", "function": "Endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis. Acts as a cofactor for thrombin activation of protein C/PROC on the surface of vascular endothelial cells leading to initiation of the activated protein C anticoagulant pathway. Also accelerates the activation of the plasma carboxypeptidase B2/CPB2, which catalyzes removal of C-terminal basic amino acids from its substrates including kinins or anaphylatoxins leading to fibrinolysis inhibition (By similarity). Plays critical protective roles in changing the cleavage specificity of protease-activated receptor 1/PAR1, inhibiting endothelial cell permeability and inflammation (PubMed:38174561). Suppresses inflammation distinctly from its anticoagulant cofactor activity by sequestering HMGB1 thereby preventing it from engaging cellular receptors such as RAGE and contributing to the inflammatory response (By similarity)., [UniProtKB, UniProtKB, PubMed]; Engineering Pancreatic Islets to Transiently Codisplay on Their Surface Thrombomodulin and CD47 Immunomodulatory Proteins as a Means of Mitigating Instant Blood-Mediated Inflammatory Reaction following Intraportal Transplantation., [RefSeq, PubMed]; Epigenetic repression of THBD transcription by BRG1 contributes to deep vein thrombosis., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 29, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 36, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005509 calcium ion binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0005774 vacuolar membrane", "go_biological_process": "GO:0007596 blood coagulation;GO:0007565 female pregnancy;GO:0030195 negative regulation of blood coagulation;GO:0050819 negative regulation of coagulation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P15306-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000011000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15533-1", "uniprot_id": [ { "id": "TR30A_MOUSE", "url": "https://www.uniprot.org/uniprot/P15533", "type": "external" } ], "mass": 57330.0, "length": 496, "protein_name": "Tripartite motif-containing protein 30A", "gene_name": "Trim30a", "organism": "Mouse", "refseq_name": "tripartite motif-containing protein 30A", "refseq_ac": [ { "id": "NP_033125", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033125", "type": "external" } ], "gene_names_uniprotkb": "Trim30a; Rpt-1; Rpt1; Trim30", "gene_names_refseq": "Rpt-1; Rpt1; Trim30a; Trim30", "protein_names_uniprotkb": "Tripartite motif-containing protein 30A; Down regulatory protein of interleukin-2 receptor; Tripartite motif-containing protein 30", "protein_names_refseq": "down regulatory protein of interleukin-2 receptor; regulatory protein, T lymphocyte 1; tripartite motif protein 30; tripartite motif-containing 30; tripartite motif-containing protein 30A; tripartite motif-containing protein 30", "tax_id": 10090, "disease": "", "pathway": " (mmu:20128)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11331580;18345001;19147168;21048113;2965815;30084848;34428180;37753964", "class_list": "", "function": "Suppression of protein quality control system by TRIM30a sensitises tumour cells to NK cell-mediated immune surveillance., [RefSeq, PubMed]; Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UV85;Q3UZ29;Q99K55;Q99PQ7;Q99PQ8;Q99PQ9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body", "go_biological_process": "GO:0046596 regulation of viral entry into host cell;GO:0044790 suppression of viral release by host;GO:0006351 DNA-templated transcription;GO:0043410 positive regulation of MAPK cascade;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P15533-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59528-1", "uniprot_id": [ { "id": "TR123_MOUSE", "url": "https://www.uniprot.org/uniprot/P59528", "type": "external" } ], "mass": 38032.0, "length": 333, "protein_name": "Taste receptor type 2 member 123", "gene_name": "Tas2r123", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 123", "refseq_ac": [ { "id": "NP_996908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996908", "type": "external" } ], "gene_names_uniprotkb": "Tas2r123; T2r55; Tas2r23", "gene_names_refseq": "T2R23; Tas2r123; Tas2r23; mGR23; mt2r55; t2r55", "protein_names_uniprotkb": "Taste receptor type 2 member 123; STC9-2; T2R123; T2R23; Taste receptor type 2 member 23; mT2R55", "protein_names_refseq": "STC9-2; T2R123; taste receptor type 2 member 123; taste receptor type 2 member 23", "tax_id": 10090, "disease": "", "pathway": " (mmu:353167)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11696554;11854532;12139982;12581520;12679530;34428180", "class_list": "", "function": "Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q7M714", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P59528-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UDK1-1", "uniprot_id": [ { "id": "TRAD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UDK1", "type": "external" } ], "mass": 64283.0, "length": 580, "protein_name": "TRAF-type zinc finger domain-containing protein 1", "gene_name": "Trafd1", "organism": "Mouse", "refseq_name": "TRAF-type zinc finger domain-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001156942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156942", "type": "external" } ], "gene_names_uniprotkb": "Trafd1; Fln29", "gene_names_refseq": "1110008K06Rik; Fln29; Trafd1", "protein_names_uniprotkb": "TRAF-type zinc finger domain-containing protein 1; Protein FLN29", "protein_names_refseq": "FLN29 gene product; TRAF-type zinc finger domain-containing protein 1 isoform 1; TRAF-type zinc finger domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:231712)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16221674;18849341;21750661;25992615;31219806;34428180;36210013;37828378", "class_list": "", "function": "FLN29 is a new negative feedback regulator of TLR signaling, [RefSeq, PubMed]; FLN29, in addition to playing a negative regulatory role in the TLR4 signaling pathway, negatively regulates the RIG-I-like helicase signaling pathway at the level of IPS-1/TRAF6 and IPS-1/TRAF3 complexes, [RefSeq, PubMed]; Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; TRAFD1, in association with Plekhm1/Rab7-positive late endosomes-early lysosomes, has a previously unknown role in vesicle trafficking, acidification, and resorption in osteoclasts Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFI8", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0045824 negative regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3UDK1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YW29-1", "uniprot_id": [ { "id": "D3YW29_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YW29", "type": "external" } ], "mass": 86455.0, "length": 759, "protein_name": "RNA exonuclease 5", "gene_name": "Rexo5", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rexo5; 2610020H08Rik", "gene_names_refseq": "", "protein_names_uniprotkb": "RNA exonuclease 5", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0004527 exonuclease activity;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0031125 rRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3YW29-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923T7-1", "uniprot_id": [ { "id": "TRIM7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q923T7", "type": "external" } ], "mass": 57021.0, "length": 510, "protein_name": "E3 ubiquitin-protein ligase TRIM7", "gene_name": "Trim7", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase TRIM7 isoform 1", "refseq_ac": [ { "id": "NP_444396", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444396", "type": "external" } ], "gene_names_uniprotkb": "Trim7; Gnip", "gene_names_refseq": "Trim7", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM7; 2.3.2.27; Glycogenin-interacting protein; Tripartite motif-containing protein 7", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM7 isoform 1; E3 ubiquitin-protein ligase TRIM7; glycogenin-interacting protein; tripartite motif protein 7; tripartite motif-containing protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:94089)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11331580;21750661;26740625;29466708;30928727;32126128;34105348;34428180;34512666;35822049;35972292;36576150", "class_list": "", "function": "E3 ubiquitin-protein ligase that have both tumor-promoting and tumor-suppressing activities and functions in several biological processes including innate immunity, regulation of ferroptosis as well as cell proliferation and migration. Acts as an antiviral effector against multiple viruses by targeting specific viral proteins for ubiquitination and degradation including norovirus NTPase protein. Mechanistically, recognizes the C-terminal glutamine-containing motif generated by viral proteases that process the polyproteins and trigger their ubiquitination and subsequent degradation (PubMed:35972292). Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation (By similarity). Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of pro-inflammatory cytokines and type I interferon (PubMed:30928727). Also plays a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response. Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation. Mediates the ubiquitination of the SIN3-HDAC chromatin remodeling complex component BRMS1. Modulates NCOA4-mediated ferritinophagy and ferroptosis in glioblastoma cells by ubiquitinating NCOA4, leading to its degradation (PubMed:32126128)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Findings suggested a novel function of RNF90 in innate immunity. Publication Status: Online-Only, [RefSeq, PubMed]; GNIP1 is an ubiquitin ligase with a markedly glycogenic effect in skeletal muscle., [RefSeq, PubMed]; Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS. Publication Status: Online-Only, [RefSeq, PubMed]; TRIM7 may facilitate the TLR4-mediated innate response via its E3 ligase domain in macrophages., [RefSeq, PubMed]; TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5NCB6;Q99PQ5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0045087 innate immune response;GO:0016567 protein ubiquitination;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q923T7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q9Q2-1", "uniprot_id": [ { "id": "E9Q9Q2_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q9Q2", "type": "external" } ], "mass": 124387.0, "length": 1135, "protein_name": "R3H domain containing 1", "gene_name": "R3hdm1", "organism": "Mouse", "refseq_name": "R3H domain-containing protein 1", "refseq_ac": [ { "id": "NP_861415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861415", "type": "external" } ], "gene_names_uniprotkb": "R3hdm1", "gene_names_refseq": "R3hdm1; R3hdm", "protein_names_uniprotkb": "R3H domain containing 1", "protein_names_refseq": "R3H domain (binds single-stranded nucleic acids); R3H domain 1 (binds single-stranded nucleic acids); R3H domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:226412)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19144319;21750661;24129315;30059200", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "E9Q9Q2-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z120-1", "uniprot_id": [ { "id": "TRMB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z120", "type": "external" } ], "mass": 30603.0, "length": 268, "protein_name": "tRNA (guanine-N(7)-)-methyltransferase", "gene_name": "Mettl1", "organism": "Mouse", "refseq_name": "tRNA (guanine-N(7)-)-methyltransferase", "refseq_ac": [ { "id": "NP_034922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034922", "type": "external" } ], "gene_names_uniprotkb": "Mettl1; METTL1", "gene_names_refseq": "2810012D02Rik; Mettl1", "protein_names_uniprotkb": "tRNA (guanine-N(7)-)-methyltransferase; 2.1.1.-; 2.1.1.33; Methyltransferase-like protein 1; mRNA (guanine-N(7)-)-methyltransferase; miRNA (guanine-N(7)-)-methyltransferase; tRNA (guanine(46)-N(7))-methyltransferase; tRNA(m7G46)-methyltransferase", "protein_names_refseq": "mRNA (guanine-N(7)-)-methyltransferase; methyltransferase like 1; miRNA (guanine-N(7)-)-methyltransferase; tRNA (guanine-N(7)-)-methyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:17299)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10329009;21750661;29983320;31031084;34352206;35598182;38810124", "class_list": "", "function": "Catalytic component of METTL1-WDR4 methyltransferase complex that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (By similarity). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop (By similarity). M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay (By similarity). Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs (PubMed:29983320). Internal N(7)-methylguanine methylation of mRNAs in response to stress promotes their relocalization to stress granules, thereby suppressing their translation (PubMed:29983320). Also methylates a specific subset of miRNAs, such as let-7 (By similarity). N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA) (By similarity). Acts as a regulator of embryonic stem cell self-renewal and differentiation (PubMed:29983320)., [UniProtKB, HAMAP, PubMed]; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA., [UniProtKB, HAMAP]; Eliminating METTL1-mediated accumulation of PMN-MDSCs prevents hepatocellular carcinoma recurrence after radiofrequency ablation., [RefSeq, PubMed]; METTL1 acts as a methyltransferase for a subset of internal N(7)-methylguanosine sites in mRNA., [RefSeq, PubMed]; The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TU83;Q921G5", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.33", "type": "external" } ], "go_molecular_function": "GO:0000049 tRNA binding;GO:0008176 tRNA (guanine(46)-N7)-methyltransferase activity;GO:0160090 internal mRNA (guanine-N7-)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0043527 tRNA methyltransferase complex", "go_biological_process": "GO:0036265 RNA (guanine-N7)-methylation;GO:0006400 tRNA modification;GO:0030488 tRNA methylation;GO:0033554 cellular response to stress;GO:0034063 stress granule assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z120-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1J9-1", "uniprot_id": [ { "id": "TOR2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1J9", "type": "external" } ], "mass": 35897.0, "length": 321, "protein_name": "Torsin-2A", "gene_name": "Tor2a", "organism": "Mouse", "refseq_name": "torsin-2A isoform 1 precursor", "refseq_ac": [ { "id": "NP_690013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690013", "type": "external" } ], "gene_names_uniprotkb": "Tor2a", "gene_names_refseq": "Prosalusin; Tor2a", "protein_names_uniprotkb": "Torsin-2A; Torsin family 2 member A", "protein_names_refseq": "torsin-2A isoform 1 precursor; torsin-2A", "tax_id": 10090, "disease": "torsion dystonia 1 (Disease Ontology:DOID:0060730); dystonia (Disease Ontology:DOID:543)", "pathway": " (mmu:30933)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;16364897;16697365;20015956;21750661;27802388", "class_list": "", "function": "Salusin may be a endocrine and/or paracrine factor able to increase intracellular calcium concentrations and induce cell mitogenesis. Salusin may also be a potent hypotensive peptide (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9562, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBH0;Q3TC01;Q3V4D1;Q8R5B5", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005788 endoplasmic reticulum lumen;GO:0005635 nuclear envelope;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8R1J9-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z321-1", "uniprot_id": [ { "id": "TOP3B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z321", "type": "external" } ], "mass": 96949.0, "length": 862, "protein_name": "DNA topoisomerase 3-beta-1", "gene_name": "Top3b", "organism": "Mouse", "refseq_name": "DNA topoisomerase 3-beta-1", "refseq_ac": [ { "id": "NP_001313505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001313505", "type": "external" } ], "gene_names_uniprotkb": "Top3b; Top3b1", "gene_names_refseq": "Top3b", "protein_names_uniprotkb": "DNA topoisomerase 3-beta-1; 5.6.2.1; DNA topoisomerase III beta-1", "protein_names_refseq": "DNA topoisomerase 3-beta-1; DNA topoisomerase III beta-1; Topo III beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:21976)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12591952;21750661;31219806;34428180;34884616;36966960;9786843", "class_list": "", "function": "DNA topoisomerase III beta has a role in infertility and aneuploidy, [RefSeq, PubMed]; DNA topoisomerase Top3beta is impacted by early life stress in the developing female and male rat brain., [RefSeq, PubMed]; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activity., [UniProtKB]; Topoisomerase IIIbeta Deficiency Induces Neuro-Behavioral Changes and Brain Connectivity Alterations in Mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity;GO:0140226 RNA topoisomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000793 condensed chromosome;GO:0140225 DNA topoisomerase III-beta-TDRD3 complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0007059 chromosome segregation;GO:0006265 DNA topological change", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z321-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q459-1", "uniprot_id": [ { "id": "E9Q459_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q459", "type": "external" } ], "mass": 73446.0, "length": 650, "protein_name": "Zinc finger protein 160", "gene_name": "Zfp160", "organism": "Mouse", "refseq_name": "zinc finger protein 160", "refseq_ac": [ { "id": "NP_663458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663458", "type": "external" } ], "gene_names_uniprotkb": "Zfp160", "gene_names_refseq": "6720480D16Rik; F11; HKr18; HZF5; KR18; Zfp160; mKIAA1611; mszf47", "protein_names_uniprotkb": "Zinc finger protein 160", "protein_names_refseq": "zinc finger protein 160", "tax_id": 10090, "disease": "", "pathway": " (mmu:224585); (R-MMU-212436); (R-MMU-9843940)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0031981 nuclear lumen;GO:0005634 nucleus", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q459-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "K7N6T2-1", "uniprot_id": [ { "id": "K7N6T2_MOUSE", "url": "https://www.uniprot.org/uniprot/K7N6T2", "type": "external" } ], "mass": 97680.0, "length": 851, "protein_name": "Vomeronasal 2, receptor 67", "gene_name": "Vmn2r67", "organism": "Mouse", "refseq_name": "vomeronasal receptor Vmn2r67", "refseq_ac": [ { "id": "NP_001096049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096049", "type": "external" } ], "gene_names_uniprotkb": "Vmn2r67", "gene_names_refseq": "EG620672; Vmn2r67", "protein_names_uniprotkb": "Vomeronasal 2, receptor 67", "protein_names_refseq": "omeronasal 2, receptor 67; vomeronasal receptor Vmn2r67", "tax_id": 10090, "disease": "", "pathway": " (mmu:620672)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "K7N6T2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PP9-1", "uniprot_id": [ { "id": "TRI16_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PP9", "type": "external" } ], "mass": 62943.0, "length": 556, "protein_name": "Tripartite motif-containing protein 16", "gene_name": "Trim16", "organism": "Mouse", "refseq_name": "tripartite motif-containing protein 16", "refseq_ac": [ { "id": "NP_444399", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444399", "type": "external" } ], "gene_names_uniprotkb": "Trim16; Ebbp", "gene_names_refseq": "9130006M08Rik; EBBP; Trim16", "protein_names_uniprotkb": "Tripartite motif-containing protein 16; 2.3.2.27; E3 ubiquitin-protein ligase TRIM16; Estrogen-responsive B box protein", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM16; estrogen-responsive B box protein; tripartite motif protein 16; tripartite motif-containing protein 16", "tax_id": 10090, "disease": "", "pathway": " (mmu:94092)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11331580;11919186;21750661;23341783;25428506;30084848;32251645;34146477;35437018;36208489", "class_list": "", "function": "E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage., [UniProtKB, UniProtKB]; TRIM16 exerts protective function on myocardial ischemia/reperfusion injury through reducing pyroptosis and inflammation via NLRP3 signaling., [RefSeq, PubMed]; TRIM16 protects from OGD/R-induced oxidative stress in cultured hippocampal neurons by enhancing Nrf2/ARE antioxidant signaling via downregulation of Keap1., [RefSeq, PubMed]; The E3 Ligase TRIM16 Is a Key Suppressor of Pathological Cardiac Hypertrophy., [RefSeq, PubMed]; Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1., [RefSeq, PubMed]; We demonstrate that genetic variation in Trim16 leads to its strain-dependent expression, which alters susceptibility to bleomycin-induced pulmonary fibrosis in mice. Erratum:[PLoS Genet. 2013 Oct;9(10). doi:10.1371/annotation/f184e509-5c53-48da-b94a-b7517f591b3e. Depault, Francois [added]], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPY6;Q8C332;Q8C6V0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0019966 interleukin-1 binding;GO:0061630 ubiquitin protein ligase activity;GO:0032089 NACHT domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016605 PML body", "go_biological_process": "GO:0032526 response to retinoic acid;GO:0045893 positive regulation of DNA-templated transcription;GO:0060416 response to growth hormone;GO:0032731 positive regulation of interleukin-1 beta production;GO:0048386 positive regulation of retinoic acid receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99PP9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BYY4-1", "uniprot_id": [ { "id": "TT39B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BYY4", "type": "external" } ], "mass": 70293.0, "length": 617, "protein_name": "Tetratricopeptide repeat protein 39B", "gene_name": "Ttc39b", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 39B", "refseq_ac": [ { "id": "NP_081514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081514", "type": "external" } ], "gene_names_uniprotkb": "Ttc39b; 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Ccdc76", "gene_names_refseq": "4631408H19Rik; A330067P21; A930028L21Rik; Ccdc76; Trmt13", "protein_names_uniprotkb": "tRNA:m(4)X modification enzyme TRM13 homolog; 2.1.1.225; Coiled-coil domain-containing protein 76", "protein_names_refseq": "coiled-coil domain containing 76; coiled-coil domain-containing protein 76; tRNA [Gm4] methyltransferase; tRNA guanosine-2'-O-methyltransferase TRM13 homolog; tRNA methyltransferase 13 homolog; tRNA:m(4)X modification enzyme TRM13 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:229780)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;35820727", "class_list": "", "function": "tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.225", "type": "external" } ], "go_molecular_function": "GO:0008175 tRNA methyltransferase activity;GO:0106050 tRNA 2'-O-methyltransferase activity;GO:0008270 zinc ion binding;GO:0008168 methyltransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0030488 tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BYH3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D289-1", "uniprot_id": [ { "id": "TPC6B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D289", "type": "external" } ], "mass": 17936.0, "length": 158, "protein_name": "Trafficking protein particle complex subunit 6B", "gene_name": "Trappc6b", "organism": "Mouse", "refseq_name": "trafficking protein particle complex subunit 6B isoform 2", "refseq_ac": [ { "id": "NP_001293146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001293146", "type": "external" } ], "gene_names_uniprotkb": "Trappc6b", "gene_names_refseq": "5830498C14Rik; Trappc6b", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 6B; TRAPP complex subunit 6B", "protein_names_refseq": "TRAPP complex subunit 6B; trafficking protein particle complex subunit 6B isoform 2; trafficking protein particle complex subunit 6B", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy (Disease Ontology:DOID:0060934)", "pathway": " (mmu:78232); (R-MMU-204005); (R-MMU-8876198)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "16828797;21750661;34428180;37507081", "class_list": "", "function": "Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic (By similarity). Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005801 cis-Golgi network;GO:0005802 trans-Golgi network;GO:0030008 TRAPP complex", "go_biological_process": "GO:0007399 nervous system development;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006901 vesicle coating;GO:0099022 vesicle tethering;GO:0048193 Golgi vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D289-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6PZL4-1", "uniprot_id": [ { "id": "F6PZL4_MOUSE", "url": "https://www.uniprot.org/uniprot/F6PZL4", "type": "external" } ], "mass": 75930.0, "length": 682, "protein_name": "Paired-Ig-like receptor A13", "gene_name": "Pira13", "organism": "Mouse", "refseq_name": "leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X1", "refseq_ac": [ { "id": "XP_003084730", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003084730", "type": "external" } ], "gene_names_uniprotkb": "Pira13; 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Trim41", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM41; 2.3.2.27; Tripartite motif-containing protein 41", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM41; RING-type E3 ubiquitin transferase TRIM41; tripartite motif-containing protein 41", "tax_id": 10090, "disease": "", "pathway": " (mmu:211007); (R-MMU-983168)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "17893151;20485683;21750661;30485814;33640899;34428180;35648791", "class_list": "", "function": "E3 ligase that plays essential roles in innate antiviral response (PubMed:33640899). Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections (By similarity). Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS (By similarity). Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways (PubMed:33640899). Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response (PubMed:30485814)., [UniProtKB, UniProtKB, PubMed, PubMed]; RINCK is an E3 ligase that specifically recognizes the C1 domain of PKC isoforms, [RefSeq, PubMed]; Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0001650 fibrillar center;GO:0005737 cytoplasm", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0071222 cellular response to lipopolysaccharide;GO:0071225 cellular response to muramyl dipeptide;GO:0060340 positive regulation of type I interferon-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5NCC3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61187-1", "uniprot_id": [ { "id": "TS101_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61187", "type": "external" } ], "mass": 44124.0, "length": 391, "protein_name": "Tumor susceptibility gene 101 protein", "gene_name": "Tsg101", "organism": "Mouse", "refseq_name": "tumor susceptibility gene 101 protein isoform 1", "refseq_ac": [ { "id": "NP_068684", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068684", "type": "external" } ], "gene_names_uniprotkb": "Tsg101", "gene_names_refseq": "CC2; Tsg101", "protein_names_uniprotkb": "Tumor susceptibility gene 101 protein; ESCRT-I complex subunit TSG101", "protein_names_refseq": "ESCRT-I complex subunit TSG101; tumor susceptibility gene 101 protein isoform 1; tumor susceptibility gene 101 protein", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); ovarian cancer (Disease Ontology:DOID:2394); endometrial adenocarcinoma (Disease Ontology:DOID:2870); cervix carcinoma (Disease Ontology:DOID:2893); carcinoma (Disease Ontology:DOID:305); breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (mmu:22088); (R-MMU-917729)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10888872;12802020;12927808;15908698;19703557;21750661;25428506;28135057;28528544;29187734;30084848;30779550;31219806;34428180;35820727;40684658;40997131;8616888;9840940", "class_list": "", "function": "Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0003714 transcription corepressor activity;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome", "go_biological_process": "GO:1990182 exosomal secretion;GO:1903774 positive regulation of viral budding via host ESCRT complex;GO:2000397 positive regulation of ubiquitin-dependent endocytosis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q61187-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ET35-1", "uniprot_id": [ { "id": "TR13B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ET35", "type": "external" } ], "mass": 26947.0, "length": 249, "protein_name": "Tumor necrosis factor receptor superfamily member 13B", "gene_name": "Tnfrsf13b", "organism": "Mouse", "refseq_name": "tumor necrosis factor receptor superfamily member 13B", "refseq_ac": [ { "id": "NP_067324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067324", "type": "external" } ], "gene_names_uniprotkb": "Tnfrsf13b; Taci", "gene_names_refseq": "1200009E08Rik; Taci; Tnfrsf13b", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 13B; Transmembrane activator and CAML interactor", "protein_names_refseq": "transmembrane activator and CAML interactor; transmembrane activator and calcium-modulating and cyclophilin ligand interactor; tumor necrosis factor receptor superfamily member 13B", "tax_id": 10090, "disease": "common variable immunodeficiency 2 (Disease Ontology:DOID:0081145); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:57916); (R-MMU-5669034)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10880535;10881172;11429548;21750661;26495903;34111031;34146342", "class_list": "", "function": "Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; TACI haploinsufficiency protects against BAFF-driven humoral autoimmunity in mice., [RefSeq, PubMed]; TNFRSF13B polymorphisms counter microbial adaptation to enteric IgA. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DBZ3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0002250 adaptive immune response;GO:0002244 hematopoietic progenitor cell differentiation;GO:0030889 negative regulation of B cell proliferation;GO:0001782 B cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9ET35-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVC5-1", "uniprot_id": [ { "id": "TRPC7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVC5", "type": "external" } ], "mass": 99475.0, "length": 862, "protein_name": "Short transient receptor potential channel 7", "gene_name": "Trpc7", "organism": "Mouse", "refseq_name": "short transient receptor potential channel 7 isoform 1", "refseq_ac": [ { "id": "NP_036165", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036165", "type": "external" } ], "gene_names_uniprotkb": "Trpc7; Trp7; Trrp8", "gene_names_refseq": "TRP7; Trpc7; Trrp8", "protein_names_uniprotkb": "Short transient receptor potential channel 7; TRP-7; Transient receptor protein 7; TrpC7; mTRP7", "protein_names_refseq": "short transient receptor potential channel 7 isoform 1; short transient receptor potential channel 7; transient receptor potential protein homologue TRP7; transient receptor protein 7; transient receptor protein 8", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (mmu:26946); (R-MMU-114508); (R-MMU-139853); (R-MMU-3295583)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10488066;21402151;21750661;22051675;25049394", "class_list": "", "function": "Non-selective, calcium-permeable cation channel (PubMed:10488066). Also transports maganese (PubMed:10488066). Contributes to both spontaneous and receptor stimulation-induced cationic currents (PubMed:10488066). Receptor stimulation, including that of G(q)-coupled or receptor tyrosine kinase pathways, triggers phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositides, producing diacylglycerol (DAG) that activates TRPC7 (PubMed:10488066, PubMed:22051675). May also be activated by depletion of intracellular calcium stores (PubMed:10488066). Mediates depolarization of intrinsically photosensitive retinal ganglion cells (ipRGCs) in response to light-induced melanopsin (OPN4)-mediated phototransduction via G(q)-PLC signaling, likely by forming heteromeric TRPC6-TRPC7 channels (PubMed:22051675)., [UniProtKB, PubMed, PubMed]; TRPC7 is intimately involved in the initiation of seizures both in vitro and in vivo., [RefSeq, PubMed]; The protein encoded by this gene is a member of the transient receptor potential channel family of proteins, which form six-transmembrane cation-permeable channels that are calcium permeant. Knock out mice are viable but display a reduction in the gamma wave activity that precedes seizure induction in response to a muscrarinic agonist, suggesting a functional role for this protein in initiation of seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005262 calcium channel activity;GO:0015279 store-operated calcium channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005635 nuclear envelope;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006816 calcium ion transport;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0007338 single fertilization;GO:0070588 calcium ion transmembrane transport;GO:0006828 manganese ion transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9WVC5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924W6-1", "uniprot_id": [ { "id": "TRI66_MOUSE", "url": "https://www.uniprot.org/uniprot/Q924W6", "type": "external" } ], "mass": 148001.0, "length": 1344, "protein_name": "Tripartite motif-containing protein 66", "gene_name": "Trim66", "organism": "Mouse", "refseq_name": "tripartite motif-containing protein 66 isoform 1", "refseq_ac": [ { "id": "NP_001164383", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164383", "type": "external" } ], "gene_names_uniprotkb": "Trim66; Tif1d", "gene_names_refseq": "Kiaa0298-hp; Tif1d; Trim66", "protein_names_uniprotkb": "Tripartite motif-containing protein 66; Transcriptional intermediary factor 1 delta", "protein_names_refseq": "TIF1delta; transcriptional intermediary factor 1 delta; tripartite motif-containing protein 66 isoform 1; tripartite motif-containing protein 66", "tax_id": 10090, "disease": "", "pathway": " (mmu:330627)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11528127;15322135;21750661;25428506;38719749", "class_list": "", "function": "Data suggest a role for transcriptional intermediary factor 1 (TIF1) delta in heterochromatin-mediated gene silencing during postmeiotic phases of spermatogenesis., [RefSeq, PubMed]; May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Trim66's paternal deficiency causes intrauterine overgrowth. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QKN7;E9QLR8;Q5SEK4;Q5SEK5", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0010369 chromocenter", "go_biological_process": "GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q924W6-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q8Q6-1", "uniprot_id": [ { "id": "CC141_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q8Q6", "type": "external" } ], "mass": 173644.0, "length": 1531, "protein_name": "Coiled-coil domain-containing protein 141", "gene_name": "Ccdc141", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 141", "refseq_ac": [ { "id": "NP_001020747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020747", "type": "external" } ], "gene_names_uniprotkb": "Ccdc141; Camdi", "gene_names_refseq": "2610301F02Rik; CAMDI; Ccdc141", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 141; Coiled-coil protein associated with myosin II and DISC1", "protein_names_refseq": "coiled-coil domain-containing protein 141; coiled-coil protein associated with myosin II and DISC1", "tax_id": 10090, "disease": "", "pathway": " (mmu:545428)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;20956536;21750661;27014940;27737934;31730661;34298015", "class_list": "", "function": "CAMDI is required for radial migration probably through DISC1 and myosin II-mediated centrosome positioning during neuronal development., [RefSeq, PubMed]; Ccdc141 is expressed in GnRH neurons and olfactory fibers during embryonic development and that knockdown of Ccdc141 reduces GnRH neuronal migration., [RefSeq, PubMed]; Findings showed that CAMDI regulates neuronal migration through the modulation of HDAC6 and indicate that HDAC6 hyperactivation by CAMDI deletion causes psychiatric behaviors, at least in part, through delayed radial migration due to impaired centrosomes, [RefSeq, PubMed]; KIBRA inhibited CAMDI-dependent Rab11 activation, thereby attenuating AMPAR cell surface expression. Publication Status: Online-Only, [RefSeq, PubMed]; Oscillation of Cdc20-APC/C-mediated CAMDI stability is critical for cortical neuron migration., [RefSeq, PubMed]; Plays a critical role in cortical radial and GnRH neurons migration during brain development (PubMed:20956536, PubMed:27014940). Regulates cortical radial migration by negatively controlling the activity of histone deacetylase 6 (HDAC6) and promotes centrosome maturation (PubMed:27737934). CAMDI is required for dilation formation of cortical neurons during radial migration (PubMed:34298015). Plays a critical role in learning and memory performance through regulation of AMPA-selective glutamate receptors (AMPARs) cell surface expression in competition with KIBRA (PubMed:27014940)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9731, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AST1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0021799 cerebral cortex radially oriented cell migration;GO:0007420 brain development;GO:0051963 regulation of synapse assembly;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0051642 centrosome localization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "E9Q8Q6-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH02-1", "uniprot_id": [ { "id": "TOR4A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH02", "type": "external" } ], "mass": 47586.0, "length": 426, "protein_name": "Torsin-4A", "gene_name": "Tor4a", "organism": "Mouse", "refseq_name": "torsin-4A", "refseq_ac": [ { "id": "NP_666227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666227", "type": "external" } ], "gene_names_uniprotkb": "Tor4a", "gene_names_refseq": "A830007P12Rik; Tor4a", "protein_names_uniprotkb": "Torsin-4A; Torsin family 4 member A", "protein_names_refseq": "torsin family protein C9orf167 homolog; torsin-4A", "tax_id": 10090, "disease": "", "pathway": " (mmu:227612); (R-MMU-114608)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;30084848;31219806;32152506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q921D7", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005788 endoplasmic reticulum lumen;GO:0016020 membrane;GO:0005737 cytoplasm;GO:0012505 endomembrane system", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BH02-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BX43-1", "uniprot_id": [ { "id": "TR19L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BX43", "type": "external" } ], "mass": 46518.0, "length": 436, "protein_name": "Tumor necrosis factor receptor superfamily member 19L", "gene_name": "Relt", "organism": "Mouse", "refseq_name": "tumor necrosis factor receptor superfamily member 19L isoform 1 precursor", "refseq_ac": [ { "id": "NP_796047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796047", "type": "external" } ], "gene_names_uniprotkb": "Relt; Tnfrsf19l", "gene_names_refseq": "E430021K24Rik; Relt; Tnfrsf19l", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 19L", "protein_names_refseq": "tumor necrosis factor receptor superfamily member 19L isoform 1 precursor; tumor necrosis factor receptor superfamily member 19L", "tax_id": 10090, "disease": "amelogenesis imperfecta type 3C (Disease Ontology:DOID:0111722)", "pathway": " (mmu:320100)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;30138536;30506946", "class_list": "", "function": "Findings suggest that RELT acts as a negative regulator that controls the early phase of T-cell activation probably by promoting T-cell apoptosis., [RefSeq, PubMed]; May play a role in apoptosis. Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed. Involved in dental enamel formation (PubMed:30506946)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q497Z8;Q8BTV0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006915 apoptotic process;GO:0097186 amelogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BX43-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921I1-1", "uniprot_id": [ { "id": "TRFE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921I1", "type": "external" } ], "mass": 76724.0, "length": 697, "protein_name": "Serotransferrin", "gene_name": "Tf; Trf", "organism": "Mouse", "refseq_name": "serotransferrin precursor", "refseq_ac": [ { "id": "NP_598738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598738", "type": "external" } ], "gene_names_uniprotkb": "Tf; Trf; Trf", "gene_names_refseq": "Cd176; HP; Tfn; Tf; Trf; hpx", "protein_names_uniprotkb": "Serotransferrin; Beta-1 metal-binding globulin; Siderophilin; Transferrin", "protein_names_refseq": "beta-1 metal-binding globulin; hypotransferrinemia with hemochromatosis; serotransferrin precursor; serotransferrin; siderophilin", "tax_id": 10090, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); atransferrinemia (Disease Ontology:DOID:0050649); chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); iron deficiency anemia (Disease Ontology:DOID:11758); hepatitis (Disease Ontology:DOID:2237); anemia (Disease Ontology:DOID:2355); glomerulonephritis (Disease Ontology:DOID:2921); hyperglycemia (Disease Ontology:DOID:4195); gastrointestinal system disease (Disease Ontology:DOID:77); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:22041); (R-MMU-114608); (R-MMU-381426); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-8957275); (R-MMU-917937); (R-MMU-917977)", "pathway_count": 8, "publication_count": 31, "publication_id_list": "10.1101/2023.09.13.557529;10913832;17330941;20571061;21750661;21913724;2601714;26495903;26740625;28011936;30899004;31219806;31616917;32152506;33001366;34428180;35822049;35984892;3611056;36288343;3693348;37018657;37163821;37453647;37507081;37828378;40885482;8133041;8245790;8248032;9621303", "class_list": "", "function": "Duodenal macrophages control dietary iron absorption via local degradation of transferrin., [RefSeq, PubMed]; Loss of hepatic manganese transporter ZIP8 disrupts serum transferrin glycosylation and the glutamate-glutamine cycle., [RefSeq, PubMed]; TF-containing MUC1 glycopeptides fail to entice Galectin-1 recognition of tumor-associated Thomsen-Freidenreich (TF) antigen (CD176) in solution., [RefSeq, PubMed]; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 12, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 28, "disease_count": 13, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O35421;Q3UBW7;Q58E69;Q61803;Q62357;Q62358;Q62359;Q63915;Q64515;Q8VII5;Q922C0", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0044325 transmembrane transporter binding;GO:0008198 ferrous iron binding;GO:0034986 iron chaperone activity;GO:1990459 transferrin receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0009986 cell surface", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0007166 cell surface receptor signaling pathway;GO:0019731 antibacterial humoral response;GO:0006879 intracellular iron ion homeostasis;GO:0071281 cellular response to iron ion", "synthesized_glycan_count": 0, "hit_score": 6.4, "record_id": "Q921I1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PQ1-1", "uniprot_id": [ { "id": "TR12A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PQ1", "type": "external" } ], "mass": 33320.0, "length": 284, "protein_name": "Tripartite motif-containing protein 12A", "gene_name": "Trim12a", "organism": "Mouse", "refseq_name": "tripartite motif-containing protein 12A isoform 2", "refseq_ac": [ { "id": "NP_076324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076324", "type": "external" } ], "gene_names_uniprotkb": "Trim12a; Trim12", "gene_names_refseq": "2310043C01Rik; Trim12a; Trim12", "protein_names_uniprotkb": "Tripartite motif-containing protein 12A", "protein_names_refseq": "tripartite motif protein 12; tripartite motif-containing 12; tripartite motif-containing protein 12A isoform 2; tripartite motif-containing protein 12A; tripartite motif-containing protein 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:76681)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11331580;18250455;19224205;20173027;21750661;30779550;34428180;35984892", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D704", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0046596 regulation of viral entry into host cell;GO:0045087 innate immune response;GO:0032880 regulation of protein localization;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99PQ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PCX9-1", "uniprot_id": [ { "id": "TRI37_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PCX9", "type": "external" } ], "mass": 107660.0, "length": 961, "protein_name": "E3 ubiquitin-protein ligase TRIM37", "gene_name": "Trim37", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase TRIM37 isoform 2", "refseq_ac": [ { "id": "NP_932104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932104", "type": "external" } ], "gene_names_uniprotkb": "Trim37; Kiaa0898", "gene_names_refseq": "1110032A10Rik; 2810004E07Rik; MUL; TEF3; Trim37", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM37; 2.3.2.27; RING-type E3 ubiquitin transferase TRIM37; Tripartite motif-containing protein 37", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM37 isoform 2; E3 ubiquitin-protein ligase TRIM37; RING-type E3 ubiquitin transferase TRIM37; TRAF encompassing factor 3; tripartite motif-containing protein 37", "tax_id": 10090, "disease": "mulibrey nanism (Disease Ontology:DOID:0050436)", "pathway": " (mmu:68729); (R-MMU-983168)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "16514549;21750661;22872234;25428506;25470042;30084848;31219806;33839419;34203471;34418053;34428180;34524943;36252649", "class_list": "", "function": "Aerobic glycolysis and tumor progression of hepatocellular carcinoma are mediated by ubiquitin of P53 K48-linked regulated by TRIM37., [RefSeq, PubMed]; E3 ubiquitin-protein ligase required to prevent centriole reduplication (By similarity). Probably acts by ubiquitinating positive regulators of centriole reduplication (By similarity). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome (By similarity)., [UniProtKB, UniProtKB, PubMed]; Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis., [RefSeq, PubMed]; TRIM37 negatively regulates inflammatory responses induced by virus infection via controlling TRAF6 ubiquitination., [RefSeq, PubMed]; The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which is typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. In mouse this protein is proposed to oligomerize through its coiled coil domain and has been reported to be expressed in neural crest-derived tissues as well as in tissues whose development is regulated by mesenchymal-epithelial interactions. In humans, mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder characterized by prenatal onset growth failure, cardiomyopathy and dysmorphic features. [provided by RefSeq, Jan 2013]., [RefSeq]; We here show that the mouse Trim37 gene presents several alternative splice variants, including a testis-specific transcript with an additional 3' exon., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5SX31;Q8CHC5", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0050821 protein stabilization;GO:0051865 protein autoubiquitination;GO:0045814 negative regulation of gene expression, epigenetic;GO:0016558 protein import into peroxisome matrix", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q6PCX9-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ER38-1", "uniprot_id": [ { "id": "TOR3A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ER38", "type": "external" } ], "mass": 43814.0, "length": 385, "protein_name": "Torsin-3A", "gene_name": "Tor3a", "organism": "Mouse", "refseq_name": "torsin-3A precursor", "refseq_ac": [ { "id": "NP_075630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075630", "type": "external" } ], "gene_names_uniprotkb": "Tor3a; Adir", "gene_names_refseq": "Adir; Tor3a", "protein_names_uniprotkb": "Torsin-3A; ATP-dependent interferon-responsive protein; Torsin family 3 member A", "protein_names_refseq": "ATP-dependant interferon responsive; ATP-dependent interferon-responsive protein; torsin-3A precursor; torsin-3A", "tax_id": 10090, "disease": "torsion dystonia 1 (Disease Ontology:DOID:0060730); Parkinson's disease (Disease Ontology:DOID:14330); dystonia (Disease Ontology:DOID:543)", "pathway": " (mmu:30935)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;11863361;16364897;21750661;30899004;36852467", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9Q6;Q3TDA9;Q3U5X1;Q3U8F2;Q9CR17;Q9CU67", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005737 cytoplasm;GO:0012505 endomembrane system", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9ER38-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWH5-1", "uniprot_id": [ { "id": "TRM11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWH5", "type": "external" } ], "mass": 52904.0, "length": 460, "protein_name": "tRNA (guanine(10)-N(2))-methyltransferase TRMT11", "gene_name": "Trmt11", "organism": "Mouse", "refseq_name": "tRNA (guanine(10)-N(2))-methyltransferase TRMT11 isoform 2", "refseq_ac": [ { "id": "NP_001345735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001345735", "type": "external" } ], "gene_names_uniprotkb": "Trmt11", "gene_names_refseq": "2410075D05Rik; 3110045I18Rik; Trmt11", "protein_names_uniprotkb": "tRNA (guanine(10)-N(2))-methyltransferase TRMT11; 2.1.1.214; tRNA methyltransferase 11 homolog", "protein_names_refseq": "tRNA (guanine(10)-N(2))-methyltransferase TRMT11 isoform 2; tRNA (guanine(10)-N(2))-methyltransferase TRMT11; tRNA (guanine(10)-N(2))-methyltransferase homolog; tRNA (guanine(10)-N2)-methyltransferase homolog; tRNA guanosine-2'-O-methyltransferase TRM11 homolog; tRNA methyltransferase 11 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:73681)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;28528544;31219806", "class_list": "", "function": "Catalytic subunit of the TRMT11-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 10 (m2G10) in tRNAs. This is one of the major tRNA (guanine-N(2))-methyltransferases., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80Y71", "ec_number_list": [ { "id": "2.1.1.214", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.214", "type": "external" } ], "go_molecular_function": "GO:0000049 tRNA binding;GO:0008168 methyltransferase activity;GO:0160102 tRNA (guanine(10)-N2)-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0034708 methyltransferase complex;GO:0043528 tRNA (m2G10) methyltransferase complex", "go_biological_process": "GO:0008033 tRNA processing;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CWH5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61056-1", "uniprot_id": [ { "id": "TRPC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61056", "type": "external" } ], "mass": 91213.0, "length": 793, "protein_name": "Short transient receptor potential channel 1", "gene_name": "Trpc1", "organism": "Mouse", "refseq_name": "short transient receptor potential channel 1 isoform 2", "refseq_ac": [ { "id": "NP_001298052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298052", "type": "external" } ], "gene_names_uniprotkb": "Trpc1; Trp1; Trrp1", "gene_names_refseq": "Mtrp1; Trp1; Trpc1; Trrp1", "protein_names_uniprotkb": "Short transient receptor potential channel 1; TRP-1; Transient receptor protein 1; Trp-related protein 1; TrpC1; mTrp1", "protein_names_refseq": "short transient receptor potential channel 1 isoform 2; short transient receptor potential channel 1; transient receptor protein 1; trp-related protein 1", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); autism spectrum disorder (Disease Ontology:DOID:0060041); stomach cancer (Disease Ontology:DOID:10534); neurodegenerative disease (Disease Ontology:DOID:1289); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:22063); (R-MMU-3295583); (R-MMU-5578775); (R-MMU-983695)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "20458742;21750661;38885005;8646775;9165220", "class_list": "", "function": "Forms a receptor-activated non-selective calcium permeant cation channel. Forms a heteromeric ion channel with TRPC4 or TRPC5 that has reduced calcium permeability compared to the homomeric TRPC4 or TRPC5 channel (By similarity). Also permeable to monovalent ions including sodium, lithium and cesium ions (By similarity)., [UniProtKB, UniProtKB]; Normotensive metabolic syndrome in Transient Receptor Potential Canonical Channel type 1 Trpc1-/- mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35722", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005102 signaling receptor binding;GO:0046872 metal ion binding;GO:0051117 ATPase binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007207 phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway;GO:0046541 saliva secretion;GO:0051592 response to calcium ion;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q61056-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ER41-1", "uniprot_id": [ { "id": "TOR1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ER41", "type": "external" } ], "mass": 37818.0, "length": 336, "protein_name": "Torsin-1B", "gene_name": "Tor1b", "organism": "Mouse", "refseq_name": "torsin-1B precursor", "refseq_ac": [ { "id": "NP_598434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598434", "type": "external" } ], "gene_names_uniprotkb": "Tor1b", "gene_names_refseq": "2610016F05Rik; DQ1; Tor1b; torsinB", "protein_names_uniprotkb": "Torsin-1B; 3.6.4.-; Torsin ATPase-1B; Torsin family 1 member B", "protein_names_refseq": "torsin ATPase-1B; torsin-1B precursor; torsin-1B", "tax_id": 10090, "disease": "torsion dystonia 1 (Disease Ontology:DOID:0060730); Parkinson's disease (Disease Ontology:DOID:14330); dystonia (Disease Ontology:DOID:543)", "pathway": " (mmu:30934); (R-MMU-8856825)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;16458269;20015956;20457914;21750661;26740625;30899004;32202496", "class_list": "", "function": "May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non-neural cells nuclear envelope and endoplasmic reticulum integrity. May have a redundant function with TOR1A in non-neural tissues., [UniProtKB, PubMed]; TorsinB expression was highest during late postnatal periods (from P14 onwards) and in the adult., [RefSeq, PubMed]; TorsinB overexpression prevents abnormal twisting in DYT1 dystonia mouse models. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8VEI4", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0019894 kinesin binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0031965 nuclear membrane", "go_biological_process": "GO:0034504 protein localization to nucleus;GO:0007029 endoplasmic reticulum organization;GO:0071763 nuclear membrane organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9ER41-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q9P5-1", "uniprot_id": [ { "id": "E9Q9P5_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q9P5", "type": "external" } ], "mass": 30723.0, "length": 263, "protein_name": "Predicted gene 3127", "gene_name": "Gm3127", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm3127", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene 3127", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:100041076)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q9P5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61510-1", "uniprot_id": [ { "id": "TRI25_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61510", "type": "external" } ], "mass": 71726.0, "length": 634, "protein_name": "E3 ubiquitin/ISG15 ligase TRIM25", "gene_name": "Trim25", "organism": "Mouse", "refseq_name": "E3 ubiquitin/ISG15 ligase TRIM25", "refseq_ac": [ { "id": "NP_033572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033572", "type": "external" } ], "gene_names_uniprotkb": "Trim25; Efp; Zfp147; Znf147", "gene_names_refseq": "EFP; Trim25; Zfp147", "protein_names_uniprotkb": "E3 ubiquitin/ISG15 ligase TRIM25; 2.3.2.27; 6.3.2.n3; Estrogen-responsive finger protein; RING-type E3 ubiquitin transferase TRIM25; RING-type E3 ubiquitin transferase; Tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; Zinc finger protein 147", "protein_names_refseq": "E3 ubiquitin/ISG15 ligase TRIM25; RING-type E3 ubiquitin transferase TRIM25; estrogen-responsive finger protein; tripartite motif protein 25; tripartite motif-containing protein 25; ubiquitin/ISG15-conjugating enzyme TRIM25; zinc finger protein 147", "tax_id": 10090, "disease": "", "pathway": " (mmu:217069); (R-MMU-1169408); (R-MMU-5656169); (R-MMU-9833482); (R-MMU-9909505)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;26495903;29125140;31219806;34428180;39285846;7592654", "class_list": "", "function": "ANKRD1 aggravates renal ischaemia-reperfusion injury via promoting TRIM25-mediated ubiquitination of ACSL3., [RefSeq, PubMed]; Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1. Mediates 'Lys-63'-linked polyubiquitination of the RIGI N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection. Mediates 'Lys-63'-linked polyubiquitination of IFIH1. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (By similarity). Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (PubMed:29125140). Plays an essential role in the antiviral activity of ZAP/ZC3HAV1; an antiviral protein which inhibits the replication of certain viruses. Mechanistically, mediates 'Lys-63'-linked polyubiquitination of ZAP/ZC3HAV1 that is required for its optimal binding to target mRNA. Also mediates the ubiquitination of various substrates implicated in stress granule formation, nonsense-mediated mRNA decay, nucleoside synthesis and mRNA translation and stability (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5SU70", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "6.3.2.n3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.n3", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0016874 ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0046596 regulation of viral entry into host cell;GO:0044790 suppression of viral release by host;GO:0006979 response to oxidative stress;GO:0045087 innate immune response;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q61510-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AVU5-1", "uniprot_id": [ { "id": "B1AVU5_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AVU5", "type": "external" } ], "mass": 46168.0, "length": 407, "protein_name": "Arylacetamide deacetylase like 4", "gene_name": "Aadacl4", "organism": "Mouse", "refseq_name": "arylacetamide deacetylase-like 4", "refseq_ac": [ { "id": "NP_001074717", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074717", "type": "external" } ], "gene_names_uniprotkb": "Aadacl4", "gene_names_refseq": "Aadacl4; Gm13177", "protein_names_uniprotkb": "Arylacetamide deacetylase like 4", "protein_names_refseq": "arylacetamide deacetylase-like 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:435815)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B1AVU5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91V04-1", "uniprot_id": [ { "id": "TRAM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91V04", "type": "external" } ], "mass": 43039.0, "length": 374, "protein_name": "Translocating chain-associated membrane protein 1", "gene_name": "Tram1", "organism": "Mouse", "refseq_name": "translocating chain-associated membrane protein 1", "refseq_ac": [ { "id": "NP_082449", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082449", "type": "external" } ], "gene_names_uniprotkb": "Tram1; Tram", "gene_names_refseq": "1810049E02Rik; TRAMP; Tram1", "protein_names_uniprotkb": "Translocating chain-associated membrane protein 1; Protein TRAM1", "protein_names_refseq": "translocating chain-associated membrane protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72265)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21237175;21750661;26563450;31219806;34203471;34428180;36210013;37453647", "class_list": "", "function": "Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel. Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER. May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport. Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane. Associates with the second TM domain of G protein-coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane. Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER-membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome., [UniProtKB, UniProtKB]; TRAM1 plays an essential role in the M1 polarization of microglia. TRAM1 increases M1-related gene expression., [RefSeq, PubMed]; These data indicate that TRAM is recognized by the signal recognition particle and translocon components, and suggest a membrane topology with eight transmembrane segments, including several poorly hydrophobic segments., [RefSeq, PubMed]; This gene encodes a multi-pass transmembrane protein of the endoplasmic reticulum (ER). It is involved in the process of cotranslational translocation of secretory proteins into the ER. [provided by RefSeq, Dec 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045048 protein insertion into ER membrane;GO:0006613 cotranslational protein targeting to membrane;GO:0006986 response to unfolded protein;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q91V04-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQA8-1", "uniprot_id": [ { "id": "TR136_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQA8", "type": "external" } ], "mass": 35019.0, "length": 305, "protein_name": "Taste receptor type 2 member 136", "gene_name": "Tas2r136", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 136", "refseq_ac": [ { "id": "NP_851793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851793", "type": "external" } ], "gene_names_uniprotkb": "Tas2r136; T2r52; Tas2r36", "gene_names_refseq": "Tas2r136; Tas2r36; mt2r52", "protein_names_uniprotkb": "Taste receptor type 2 member 136; T2R136; T2R36; Taste receptor type 2 member 36; mT2r52", "protein_names_refseq": "T2R136; T2R36; taste receptor type 2 member 136; taste receptor type 2 member 36", "tax_id": 10090, "disease": "", "pathway": " (mmu:353165); (R-MMU-418594); (R-MMU-420499); (R-MMU-9717207)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "12679530;12734386;21750661", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7M716", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0031514 motile cilium", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TQA8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K243-1", "uniprot_id": [ { "id": "TRI68_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K243", "type": "external" } ], "mass": 56098.0, "length": 485, "protein_name": "E3 ubiquitin-protein ligase TRIM68", "gene_name": "Trim68", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trim68; Rnf137", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM68; 2.3.2.27; RING finger protein 137; RING-type E3 ubiquitin transferase TRIM68; Tripartite motif-containing protein 68", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:101700)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;30779550;40885482", "class_list": "", "function": "Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0050681 nuclear androgen receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0045087 innate immune response;GO:0010468 regulation of gene expression;GO:0051865 protein autoubiquitination;GO:0060765 regulation of androgen receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K243-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES56-1", "uniprot_id": [ { "id": "TPPC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ES56", "type": "external" } ], "mass": 24385.0, "length": 219, "protein_name": "Trafficking protein particle complex subunit 4", "gene_name": "Trappc4", "organism": "Mouse", "refseq_name": "trafficking protein particle complex subunit 4 isoform 1", "refseq_ac": [ { "id": "NP_068561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068561", "type": "external" } ], "gene_names_uniprotkb": "Trappc4; Sbdn", "gene_names_refseq": "1500017G03Rik; HSPC172; PTD009; Sbdn; Sbd; Sdcbp2; TRS23; Trappc4", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 4; Synbindin; TRS23 homolog", "protein_names_refseq": "TRS23 homolog; synbindin; syndecan binding protein 2; trafficking protein particle complex subunit 4 isoform 1; trafficking protein particle complex subunit 4", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (mmu:60409); (R-MMU-204005); (R-MMU-8876198)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11018053;21750661;24104608;25428506;30084848;32375403;33649389;34428180", "class_list": "", "function": "Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase. Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy (By similarity). May play a role in dendrite postsynaptic membrane trafficking (PubMed:11018053)., [UniProtKB, PubMed, UniProtKB]; Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling. Publication Status: Online-Only, [RefSeq, PubMed]; Synbindin contributes to malignant phenotypes of GC by activating ERK on the Golgi, and synbindin is a potential biomarker and therapeutic target for GC., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DB31", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0016358 dendrite development;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006914 autophagy;GO:0048208 COPII vesicle coating;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9ES56-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KL14-1", "uniprot_id": [ { "id": "TPC3L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4KL14", "type": "external" } ], "mass": 20763.0, "length": 181, "protein_name": "Trafficking protein particle complex subunit 3-like protein", "gene_name": "Trappc3l", "organism": "Mouse", "refseq_name": "trafficking protein particle complex subunit 3-like protein", "refseq_ac": [ { "id": "NP_001156409", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156409", "type": "external" } ], "gene_names_uniprotkb": "Trappc3l; Bet3l", "gene_names_refseq": "Bet3l; Trappc3l", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 3-like protein; BET3-like protein; TRAPPC3-like protein", "protein_names_refseq": "BET3 like; BET3-like protein; TRAPPC3-like protein; trafficking protein particle complex subunit 3-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:692132)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May play a role in vesicular transport from endoplasmic reticulum to Golgi., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0033106 cis-Golgi network membrane;GO:0030008 TRAPP complex;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006891 intra-Golgi vesicle-mediated transport;GO:0048193 Golgi vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KL14-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBA6-1", "uniprot_id": [ { "id": "TYSD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBA6", "type": "external" } ], "mass": 59066.0, "length": 568, "protein_name": "Peroxisomal leader peptide-processing protease", "gene_name": "Tysnd1", "organism": "Mouse", "refseq_name": "peroxisomal leader peptide-processing protease isoform b", "refseq_ac": [ { "id": "NP_001259019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259019", "type": "external" } ], "gene_names_uniprotkb": "Tysnd1", "gene_names_refseq": "1300019N10Rik; Tysnd1", "protein_names_uniprotkb": "Peroxisomal leader peptide-processing protease; 3.4.21.-; Trypsin domain-containing protein 1", "protein_names_refseq": "peroxisomal leader peptide-processing protease isoform b; peroxisomal leader peptide-processing protease; trypsin domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71767); (R-MMU-9033241); (R-MMU-9033500)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "17255948;21750661;22002062;23459139;34428180;35820727", "class_list": "", "function": "Characterization of function of human TYSND1, including putative regulation by self-cleavage, [RefSeq, PubMed]; Our data established that peroxisomal processing protease Tysnd1 is necessary to mediate the physiological functions of PTS2-containing substrates., [RefSeq, PubMed]; Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids (By similarity)., [UniProtKB, PubMed]; This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also capable of removing the C-terminal peroxisomal targeting signal (PTS1) from proteins in the peroxisomal matrix. The full-length protein undergoes self-cleavage to produce shorter, potentially inactive, peptides. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0VE90", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "1.14.11.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.18", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "2.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.26", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0002020 protease binding;GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0031998 regulation of fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9DBA6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XC2-1", "uniprot_id": [ { "id": "TRM61_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80XC2", "type": "external" } ], "mass": 31639.0, "length": 290, "protein_name": "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A", "gene_name": "Trmt61a", "organism": "Mouse", "refseq_name": "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A", "refseq_ac": [ { "id": "NP_001093262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093262", "type": "external" } ], "gene_names_uniprotkb": "Trmt61a; Trm61", "gene_names_refseq": "6720458F09Rik; Gcd14; Trm61; Trmt61a", "protein_names_uniprotkb": "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; 2.1.1.-; 2.1.1.220; mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A; tRNA(m1A58)-methyltransferase subunit TRMT61A; tRNA(m1A58)MTase subunit TRMT61A", "protein_names_refseq": "mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A; tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61; tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61A; tRNA methyltransferase 61 homolog A; tRNA(m1A58)-methyltransferase subunit TRM61; tRNA(m1A58)-methyltransferase subunit TRMT61A; tRNA(m1A58)MTase subunit TRM61; tRNA(m1A58)MTase subunit TRMT61A", "tax_id": 10090, "disease": "", "pathway": " (mmu:328162)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16043508;21750661;36138184", "class_list": "", "function": "Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries., [UniProtKB, UniProtKB]; Shows conservation of the yeast TRM61 (GCD14) protein in mouse, human and Drosophila, and demonstrates functional activity of the human ortholog., [RefSeq, PubMed]; TRNA-m[1]A modification promotes T cell expansion via efficient MYC protein synthesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMD4;Q8BX33", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.218", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.218", "type": "external" }, { "id": "2.1.1.221", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.221", "type": "external" }, { "id": "2.1.1.220", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.220", "type": "external" } ], "go_molecular_function": "GO:0061953 mRNA (adenine-N1-)-methyltransferase activity;GO:0160107 tRNA (adenine(58)-N1)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031515 tRNA (m1A) methyltransferase complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0030488 tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80XC2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D4B2-1", "uniprot_id": [ { "id": "ODAD4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D4B2", "type": "external" } ], "mass": 71530.0, "length": 624, "protein_name": "Outer dynein arm-docking complex subunit 4", "gene_name": "Odad4", "organism": "Mouse", "refseq_name": "outer dynein arm-docking complex subunit 4 isoform 1", "refseq_ac": [ { "id": "NP_083194", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083194", "type": "external" } ], "gene_names_uniprotkb": "Odad4; Ttc25", "gene_names_refseq": "4933404O19Rik; Odad4; Ttc25", "protein_names_uniprotkb": "Outer dynein arm-docking complex subunit 4; TPR repeat protein 25; Tetratricopeptide repeat protein 25", "protein_names_refseq": "TPR repeat protein 25; outer dynein arm-docking complex subunit 4 isoform 1; outer dynein arm-docking complex subunit 4; tetratricopeptide repeat domain 25; tetratricopeptide repeat protein 25", "tax_id": 10090, "disease": "primary ciliary dyskinesia 35 (Disease Ontology:DOID:0110620)", "pathway": " (mmu:74407)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17971504;21750661;25860617;27486780;33347437", "class_list": "", "function": "Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Plays an essential role for the assembly of ODA-DC and for the docking of ODA in ciliary axoneme., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Report of TTC25 as a new member of the outer dynein arms docking machinery in humans and mice, [RefSeq, PubMed]; Ttc25 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BI62;Q80X58", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005930 axoneme;GO:0097729 9+2 motile cilium;GO:0097728 9+0 motile cilium", "go_biological_process": "GO:0007507 heart development;GO:0030324 lung development;GO:0007420 brain development;GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D4B2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810I2-1", "uniprot_id": [ { "id": "TRI50_MOUSE", "url": "https://www.uniprot.org/uniprot/Q810I2", "type": "external" } ], "mass": 54607.0, "length": 483, "protein_name": "E3 ubiquitin-protein ligase TRIM50", "gene_name": "Trim50", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase TRIM50 isoform 1", "refseq_ac": [ { "id": "NP_839971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_839971", "type": "external" } ], "gene_names_uniprotkb": "Trim50", "gene_names_refseq": "Trim50", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM50; 2.3.2.27; RING-type E3 ubiquitin transferase TRIM50; Tripartite motif-containing protein 50", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM50 isoform 1; E3 ubiquitin-protein ligase TRIM50; RING-type E3 ubiquitin transferase TRIM50; tripartite motif-containing protein 50", "tax_id": 10090, "disease": "", "pathway": " (mmu:215061); (R-MMU-983168)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "18398435;21750661;22792322;22872646;24308962;29604308;35820727;36178239", "class_list": "", "function": "E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1 (PubMed:29604308). In turn, promotes starvation-induced autophagy activation. Also interacts with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction (PubMed:22792322). Also promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization independent of its E3 ligase function (PubMed:36178239)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; TRIM50 promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization., [RefSeq, PubMed]; TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells, [RefSeq, PubMed]; TRIM50, via the RING domain, ubiquitinates Beclin 1 in a K63-dependent manner enhancing its binding with ULK1 and autophagy activity., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016235 aggresome", "go_biological_process": "GO:0045087 innate immune response;GO:0070201 regulation of establishment of protein localization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q810I2-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLT2-1", "uniprot_id": [ { "id": "TREA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLT2", "type": "external" } ], "mass": 65401.0, "length": 576, "protein_name": "Trehalase", "gene_name": "Treh", "organism": "Mouse", "refseq_name": "trehalase isoform 1 precursor", "refseq_ac": [ { "id": "NP_067456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067456", "type": "external" } ], "gene_names_uniprotkb": "Treh", "gene_names_refseq": "2210412M19Rik; Treh", "protein_names_uniprotkb": "Trehalase; 3.2.1.28; Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase", "protein_names_refseq": "alpha,alpha-trehalase; alpha,alpha-trehalose glucohydrolase; trehalase isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:58866)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11404018;15483270;21750661;28068606;31219806", "class_list": "glycogene;glycosylhydrolase", "function": "In mature gut of conventional mice, both beta 1,4-galactosyltransferase and trehalase are elevated and insensitive to cartisone acetate, [RefSeq, PubMed]; Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose., [UniProtKB, UniProtKB]; This gene belongs to the alpha-glucosidase family, whose members encode enzymes that carry out hydrolysis of alpha-glucoside bonds of a variety of carbohydrates. The enzyme encoded by this gene uses the disaccharide trehalose as a highly specific substrate and converts it into two glucose molecules. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]., [RefSeq]; Trehalose was also able to restore cell viability to control levels, but pre-formed fibrils (PFFs)still exhibited toxic effects on the cells. These data provide essential information regarding effects of trehalose on alphaSyn accumulation and neuronal survival on exposure to PFF, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 26, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q91ZS4", "ec_number_list": [ { "id": "3.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.28", "type": "external" } ], "go_molecular_function": "GO:0004555 alpha,alpha-trehalase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005903 brush border;GO:0016020 membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0009887 animal organ morphogenesis;GO:0005993 trehalose catabolic process;GO:0005991 trehalose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JLT2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R115-1", "uniprot_id": [ { "id": "TMM82_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R115", "type": "external" } ], "mass": 38882.0, "length": 356, "protein_name": "Transmembrane protein 82", "gene_name": "Tmem82", "organism": "Mouse", "refseq_name": "transmembrane protein 82", "refseq_ac": [ { "id": "NP_666099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666099", "type": "external" } ], "gene_names_uniprotkb": "Tmem82", "gene_names_refseq": "Tmem82", "protein_names_uniprotkb": "Transmembrane protein 82", "protein_names_refseq": "transmembrane protein 82", "tax_id": 10090, "disease": "", "pathway": " (mmu:213989)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ADF5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R115-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7M717-1", "uniprot_id": [ { "id": "TR102_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7M717", "type": "external" } ], "mass": 38450.0, "length": 329, "protein_name": "Taste receptor type 2 member 102", "gene_name": "Tas2r102", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tas2r102; T2r51", "gene_names_refseq": "", "protein_names_uniprotkb": "Taste receptor type 2 member 102; STC9-7; T2R102; mT2R51", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:387339)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11854532;12679530;21750661", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q71QD0", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0032467 positive regulation of cytokinesis;GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7M717-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYA2-1", "uniprot_id": [ { "id": "TOM40_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYA2", "type": "external" } ], "mass": 37895.0, "length": 361, "protein_name": "Mitochondrial import receptor subunit TOM40 homolog", "gene_name": "Tomm40", "organism": "Mouse", "refseq_name": "mitochondrial import receptor subunit TOM40 homolog", "refseq_ac": [ { "id": "NP_001103218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103218", "type": "external" } ], "gene_names_uniprotkb": "Tomm40; Mom35; Tom40", "gene_names_refseq": "Mom35; Tom40; Tomm40", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM40 homolog; MOM35; Mitochondrial outer membrane protein of 35 kDa; Protein Haymaker; Translocase of outer membrane 40 kDa subunit homolog", "protein_names_refseq": "haymaker protein; mitochondrial import receptor subunit TOM40 homolog; mitochondrial outer membrane protein 35; mitochondrial outer membrane protein of 35 kDa; translocase of outer membrane 40 kDa subunit homolog; translocase of outer mitochondrial membrane 40 homolog", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); cerebral infarction (Disease Ontology:DOID:3526)", "pathway": " (mmu:53333); (R-MMU-5205685)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11745481;11768756;21750661;22645316;24788674;25153642;25428506;28135057;31219806;34428180;37507081;38159656", "class_list": "", "function": "Channel-forming protein that forms part of the translocase of the outer mitochondrial membrane (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria (By similarity)., [UniProtKB, UniProtKB]; Imported into the outer mitochondrial membrane, [RefSeq, PubMed]; TOM40 mediates the effect of TSPO on postpartum depression partially through regulating calcium homeostasis in microglia., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBZ2;Q3TQA1;Q8VI26;Q8VI27;Q9Z2N1", "ec_number_list": [], "go_molecular_function": "GO:0015288 porin activity;GO:0005261 monoatomic cation channel activity;GO:0070678 preprotein binding;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006626 protein targeting to mitochondrion;GO:0030150 protein import into mitochondrial matrix;GO:0051204 protein insertion into mitochondrial membrane", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9QYA2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VE09-1", "uniprot_id": [ { "id": "TT39C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VE09", "type": "external" } ], "mass": 65445.0, "length": 580, "protein_name": "Tetratricopeptide repeat protein 39C", "gene_name": "Ttc39c", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 39C", "refseq_ac": [ { "id": "NP_082617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082617", "type": "external" } ], "gene_names_uniprotkb": "Ttc39c", "gene_names_refseq": "1700008N02Rik; 2810439F02Rik; Ttc39c", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 39C; TPR repeat protein 39C", "protein_names_refseq": "TPR repeat protein 39C; tetratricopeptide repeat protein 39C", "tax_id": 10090, "disease": "", "pathway": " (mmu:72747)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "18299400;20484733;21750661;25428506;27802388;30084848;30779550;31188487;31599954;33649389;34428180;35820727;37828378", "class_list": "", "function": "The results of this study demonstrate that muscle cell differentiation is sensitive to abnormal Ttc39c expression and that normal Ttc39c expression appears to be necessary for proper MAP Kinase and Hedgehog signal transduction in developing muscle cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CYV6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0032474 otolith morphogenesis;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8VE09-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UHV4-1", "uniprot_id": [ { "id": "TR5OS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UHV4", "type": "external" } ], "mass": 12052.0, "length": 110, "protein_name": "Putative uncharacterized protein TRPC5OS homolog", "gene_name": "Trpc5os", "organism": "Mouse", "refseq_name": "putative uncharacterized protein TRPC5OS homolog", "refseq_ac": [ { "id": "NP_001182508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182508", "type": "external" } ], "gene_names_uniprotkb": "Trpc5os; Gm15070", "gene_names_refseq": "Gm15070; Trpc5os", "protein_names_uniprotkb": "Putative uncharacterized protein TRPC5OS homolog", "protein_names_refseq": "putative uncharacterized protein TRPC5OS homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:100503240)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3UHV4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UWA4-1", "uniprot_id": [ { "id": "TRI40_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UWA4", "type": "external" } ], "mass": 27903.0, "length": 246, "protein_name": "E3 ubiquitin ligase TRIM40", "gene_name": "Trim40", "organism": "Mouse", "refseq_name": "E3 ubiquitin ligase TRIM40 isoform 1", "refseq_ac": [ { "id": "NP_001028407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028407", "type": "external" } ], "gene_names_uniprotkb": "Trim40; Gm319", "gene_names_refseq": "Gm319; Gm35; Gm865; Trim40", "protein_names_uniprotkb": "E3 ubiquitin ligase TRIM40; 2.3.2.27; Probable E3 NEDD8-protein ligase", "protein_names_refseq": "E3 ubiquitin ligase TRIM40 isoform 1; E3 ubiquitin ligase TRIM40; probable E3 NEDD8-protein ligase; ring finger RNF35; tripartite motif-containing protein 40", "tax_id": 10090, "disease": "", "pathway": " (mmu:195359)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "29117565;34161773", "class_list": "", "function": "E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response. Mediates inhibition of the RLR signaling pathway by ubiquitinating RIGI and IFIH1 receptors, leading to their proteasomal degradation. Also promotes the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation., [UniProtKB, UniProtKB]; Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation., [RefSeq, PubMed]; TRIM40 binds to MDA5 and RIG-I and promotes their K27- and K48-linked polyubiquitination via its E3 ligase activity, leading to their proteasomal degradation. TRIM40 deficiency enhances RLR-triggered signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RVT3", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0008385 IkappaB kinase complex", "go_biological_process": "GO:0045087 innate immune response;GO:1900181 negative regulation of protein localization to nucleus;GO:0030308 negative regulation of cell growth;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0042177 negative regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UWA4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V038-1", "uniprot_id": [ { "id": "TTC9A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V038", "type": "external" } ], "mass": 24351.0, "length": 219, "protein_name": "Tetratricopeptide repeat protein 9A", "gene_name": "Ttc9", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 9A", "refseq_ac": [ { "id": "NP_001028321", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028321", "type": "external" } ], "gene_names_uniprotkb": "Ttc9; Kiaa0227; Ttc9a", "gene_names_refseq": "Ttc9", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 9A; TPR repeat protein 9A", "protein_names_refseq": "TPR repeat protein 9A; tetratricopeptide repeat protein 9A", "tax_id": 10090, "disease": "opiate dependence (Disease Ontology:DOID:2559)", "pathway": " (mmu:69480)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16678794;22917536;27869229", "class_list": "", "function": "TTC9A modulates the anxiety-related behaviors through modulation of estrogen action on the serotonergic system in the dorsal raphe nucleus. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein that contains three tetratricopeptide repeats. The human gene has been shown to be hormonally regulated in breast cancer cells and may play a role in cancer cell invasion and metastasis. [provided by RefSeq, Sep 2015]., [RefSeq]; Though the function of TTC9 is not yet clear, the susceptibility of its protein level to biological and chemical agents suggests that TTC9 is a biologically significant protein., [RefSeq, PubMed]; Together with the observation that TTC9A is a direct ERalpha target gene, this study proposes that the fall and rise of TTC9A levels during lactation and involution is caused by the changes of ERalpha activity that is in turn regulated by the factors in the microenvironment., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RTC7;Q3TTA0;Q6A0A0;Q8K336", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0060348 bone development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3V038-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q505D9-1", "uniprot_id": [ { "id": "TRI67_MOUSE", "url": "https://www.uniprot.org/uniprot/Q505D9", "type": "external" } ], "mass": 82760.0, "length": 768, "protein_name": "Tripartite motif-containing protein 67", "gene_name": "Trim67", "organism": "Mouse", "refseq_name": "tripartite motif-containing protein 67", "refseq_ac": [ { "id": "NP_941034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_941034", "type": "external" } ], "gene_names_uniprotkb": "Trim67", "gene_names_refseq": "D130049O21Rik; TNL; Trim67", "protein_names_uniprotkb": "Tripartite motif-containing protein 67", "protein_names_refseq": "TRIM9-like protein TNL; tripartite motif-containing protein 67", "tax_id": 10090, "disease": "Opitz GBBB syndrome (Disease Ontology:DOID:0080697)", "pathway": " (mmu:330863)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "22337885;29911180;30016717;34428180;36012700;37686246", "class_list": "", "function": "Study shows that mice lacking Trim67 exhibit abnormal anatomy of specific brain regions, including hypotrophy of the hippocampus, striatum, amygdala, and thalamus, and thinning of forebrain commissures. Additionally, Trim67-/- mice display impairments in spatial memory, cognitive flexibility, social novelty preference, muscle function, and sensorimotor gating, whereas several other behaviors remain intact. Erratum:[eNeuro. 2019 Aug 16;6(4):ENEURO.0281-19.2019. doi: 10.1523/ENEURO.0281-19.2019. PMID: 31420404] Publication Status: Online-Only, [RefSeq, PubMed]; TRIM67 Deficiency Exacerbates Hypothalamic Inflammation and Fat Accumulation in Obese Mice. Publication Status: Online-Only, [RefSeq, PubMed]; TRIM67 Implicates in Regulating the Homeostasis and Synaptic Development of Mitral Cells in the Olfactory Bulb. Publication Status: Online-Only, [RefSeq, PubMed]; TRIM67 regulates Ras signaling via degradation of 80K-H, leading to neural differentiation including neuritogenesis., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0010976 positive regulation of neuron projection development;GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q505D9-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q562D6-1", "uniprot_id": [ { "id": "TRMO_MOUSE", "url": "https://www.uniprot.org/uniprot/Q562D6", "type": "external" } ], "mass": 47559.0, "length": 431, "protein_name": "tRNA (adenine(37)-N6)-methyltransferase", "gene_name": "Trmo", "organism": "Mouse", "refseq_name": "tRNA (adenine(37)-N6)-methyltransferase isoform 2", "refseq_ac": [ { "id": "NP_001334024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334024", "type": "external" } ], "gene_names_uniprotkb": "Trmo; 5830415F09Rik", "gene_names_refseq": "5830415F09Rik; Nap1; Trmo", "protein_names_uniprotkb": "tRNA (adenine(37)-N6)-methyltransferase; 2.1.1.-; tRNA methyltransferase O", "protein_names_refseq": "likely ortholog of H. sapiens chromosome 9 open reading frame 156 (C9orf156); nef-associated protein 1; tRNA (adenine(37)-N6)-methyltransferase isoform 2; tRNA (adenine(37)-N6)-methyltransferase; thioesterase NAP1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74753)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5H3;Q8BRJ8;Q9D3F5", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0089715 tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity;GO:0008168 methyltransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0030488 tRNA methylation;GO:0008033 tRNA processing;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q562D6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5GIG6-1", "uniprot_id": [ { "id": "TNI3K_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5GIG6", "type": "external" } ], "mass": 92575.0, "length": 834, "protein_name": "Serine/threonine-protein kinase TNNI3K", "gene_name": "Tnni3k", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase TNNI3K", "refseq_ac": [ { "id": "NP_796040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796040", "type": "external" } ], "gene_names_uniprotkb": "Tnni3k; Cark", "gene_names_refseq": "Cark; D830019J24Rik; Tnni3k", "protein_names_uniprotkb": "Serine/threonine-protein kinase TNNI3K; 2.7.11.1; Cardiac ankyrin repeat kinase; TNNI3-interacting kinase", "protein_names_refseq": "cardiac ankyrin repeat kinase; serine/threonine-protein kinase TNNI3K", "tax_id": 10090, "disease": "", "pathway": " (mmu:435766)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;19763165;21525387;37597489;37628941;37769962", "class_list": "", "function": "An improved method reveals the dual role of Tnni3k in promoting S-phase entry while suppressing cell division in cardiomyocytes., [RefSeq, PubMed]; Data identified Tnni3k, Fpgt and H28 as likely likely candidates for Vms1., [RefSeq, PubMed]; Expression Levels of the Tnni3k Gene in the Heart Are Highly Associated with Cardiac and Glucose Metabolism-Related Phenotypes and Functional Pathways. Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in cardiac physiology., [UniProtKB, UniProtKB]; Tnni3k influences cardiomyocyte S-phase activity and proliferation., [RefSeq, PubMed]; Tnni3k plays a critical role in the modulation of different forms of heart disease, and this protein may provide a novel target for therapeutic intervention., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9585, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RTJ7;Q5GIG5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0086069 bundle of His cell to Purkinje myocyte communication;GO:0007165 signal transduction;GO:1903779 regulation of cardiac conduction;GO:0055117 regulation of cardiac muscle contraction;GO:0002027 regulation of heart rate", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5GIG6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5UBV8-1", "uniprot_id": [ { "id": "TNF15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5UBV8", "type": "external" } ], "mass": 27725.0, "length": 252, "protein_name": "Tumor necrosis factor ligand superfamily member 15", "gene_name": "Tnfsf15", "organism": "Mouse", "refseq_name": "tumor necrosis factor ligand superfamily member 15", "refseq_ac": [ { "id": "NP_796345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796345", "type": "external" } ], "gene_names_uniprotkb": "Tnfsf15; Tl1; Vegi", "gene_names_refseq": "Tl1a; Tl1; Tnfsf15; Tnlg1b; Vegi", "protein_names_uniprotkb": "Tumor necrosis factor ligand superfamily member 15; TNF ligand-related molecule 1; Vascular endothelial cell growth inhibitor", "protein_names_refseq": "TNF ligand-related molecule 1; bM20K13.3 (tumor necrosis factor (ligand) superfamily, member 15); tumor necrosis factor ligand 1b; tumor necrosis factor ligand superfamily member 15; vascular endothelial cell growth inhibitor; vascular endothelial growth inhibitor", "tax_id": 10090, "disease": "inflammatory bowel disease 16 (Disease Ontology:DOID:0110896)", "pathway": " (mmu:326623); (R-MMU-5669034)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11911831;15702971;16698931;16920944;37921408;38348035;38597952;38987753", "class_list": "", "function": "Cytokine that signals through TNFRSF25 receptor. Functions as a T-cell costimulator, that increases IL-2 responsiveness and secretion of proinflammatory cytokines which enhances T-cell activation, proliferation and the survival of activated T-cells (PubMed:11911831). Inhibits vascular endothelial growth and angiogenesis (in vitro) (By similarity)., [UniProtKB, PubMed, UniProtKB]; Findings suggest that the transcription factor NF-kappaB plays an important role in the regulation of VEGI expression, [RefSeq, PubMed]; Induction of intestinal inflammation is associated with significant up-regulation of TL1A and tm DR3 in the inflamed mucosa, [RefSeq, PubMed]; Necroptosis plays a role in TL1A-induced airway inflammation and barrier damage in asthma. Publication Status: Online-Only, [RefSeq, PubMed]; Neonatal CD4+ CD3- cells up-regulate both CD30L and OX40L after adoptive transfer into an adult recipient, [RefSeq, PubMed]; Roles of tumor necrosis factor-like ligand 1A in gammadeltaT-cell activation and psoriasis pathogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; TL1A is an epithelial alarmin that cooperates with IL-33 for initiation of allergic airway inflammation., [RefSeq, PubMed]; TNFSF15 facilitates the differentiation of CD11b[+] myeloid cells into vascular pericytes in tumors., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RR33;E9PVT2;F6VXB8;Q8K3Y8", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5UBV8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69ZB3-1", "uniprot_id": [ { "id": "TSYL5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69ZB3", "type": "external" } ], "mass": 44303.0, "length": 406, "protein_name": "Testis-specific Y-encoded-like protein 5", "gene_name": "Tspyl5", "organism": "Mouse", "refseq_name": "testis-specific Y-encoded-like protein 5", "refseq_ac": [ { "id": "NP_001078890", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078890", "type": "external" } ], "gene_names_uniprotkb": "Tspyl5; Kiaa1750", "gene_names_refseq": "6330530B20; E130308C19Rik; Tspyl5", "protein_names_uniprotkb": "Testis-specific Y-encoded-like protein 5; TSPY-like protein 5", "protein_names_refseq": "TSPY-like protein 5; testis-specific Y-encoded-like protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:239364)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "37675714;38185096", "class_list": "", "function": "Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7 (By similarity)., [UniProtKB]; Mouse Tspyl5 promotes spermatogonia proliferation through enhancing Pcna-mediated DNA replication., [RefSeq, PubMed]; TSPYL5 inhibits the tumorigenesis of colorectal cancer cells in vivo by triggering DNA damage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0051260 protein homooligomerization;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0031398 positive regulation of protein ubiquitination;GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q69ZB3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IRU2-1", "uniprot_id": [ { "id": "TPM4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6IRU2", "type": "external" } ], "mass": 28468.0, "length": 248, "protein_name": "Tropomyosin alpha-4 chain", "gene_name": "Tpm4", "organism": "Mouse", "refseq_name": "tropomyosin alpha-4 chain", "refseq_ac": [ { "id": "NP_001001491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001491", "type": "external" } ], "gene_names_uniprotkb": "Tpm4", "gene_names_refseq": "2610528G24Rik; Tpm4.2cy; Tpm4.2; Tpm4", "protein_names_uniprotkb": "Tropomyosin alpha-4 chain; Tropomyosin-4", "protein_names_refseq": "tropomyosin alpha-4 chain", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); blood platelet disease (Disease Ontology:DOID:2218)", "pathway": " (mmu:326618); (R-MMU-390522); (R-MMU-445355); (R-MMU-9013424)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "16765662;17968984;18036591;21540332;21750661;22645316;24788674;25153642;26495903;28134622;28135057;34428180", "class_list": "", "function": "Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium (By similarity). Plays a role in platelet biogenesis (PubMed:28134622)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Findings demonstrate a nonredundant role for TPM4 in platelet biogenesis in humans and mice and reveal that truncating variants in TPM4 cause a previously undescribed dominant Mendelian platelet disorder., [RefSeq, PubMed]; These results indicate that Tm-4 plays a role in regulating adhesion structures of osteoclasts, most likely by stabilizing the actin microfilaments present in podosomes and the sealing zone., [RefSeq, PubMed]; Tm-4 is specifically enriched within and around osteoclast attachment structures, the sealing zone and podosomes., [RefSeq, PubMed]; Tropomyosin 4 defines longitudinal filaments in mouse models of muscular dystrophy and nemaline myopathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0015629 actin cytoskeleton;GO:0002102 podosome;GO:0001725 stress fiber", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0030220 platelet formation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q6IRU2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PFY8-1", "uniprot_id": [ { "id": "TRI45_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PFY8", "type": "external" } ], "mass": 64257.0, "length": 580, "protein_name": "E3 ubiquitin-protein ligase TRIM45", "gene_name": "Trim45", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase TRIM45 isoform b", "refseq_ac": [ { "id": "NP_001159424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159424", "type": "external" } ], "gene_names_uniprotkb": "Trim45", "gene_names_refseq": "4921530N01Rik; Trim45", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM45; 2.3.2.27; RING finger protein 99; Tripartite motif-containing protein 45", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM45 isoform b; E3 ubiquitin-protein ligase TRIM45; RING finger protein 99; tripartite motif-containing protein 45", "tax_id": 10090, "disease": "", "pathway": " (mmu:229644)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;35217833;36681779;38037161", "class_list": "", "function": "E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response (PubMed:36681779). Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degradation via the proteasomal pathway and inhibition of the TLR-mediated inflammatory immune response. May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway., [UniProtKB, UniProtKB, PubMed]; E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response. Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degradation via the proteasomal pathway and inhibition of the TLR-mediated inflammatory immune response. May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway., [UniProtKB, UniProtKB]; TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy. Publication Status: Online-Only, [RefSeq, PubMed]; TRIM45 causes neuronal damage by aggravating microglia-mediated neuroinflammation upon cerebral ischemia and reperfusion injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q2K9;Q3U5H4;Q8BVT5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045171 intercellular bridge;GO:0005634 nucleus", "go_biological_process": "GO:0006954 inflammatory response;GO:0050728 negative regulation of inflammatory response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0060348 bone development;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PFY8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7M707-1", "uniprot_id": [ { "id": "TR109_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7M707", "type": "external" } ], "mass": 36750.0, "length": 316, "protein_name": "Taste receptor type 2 member 109", "gene_name": "Tas2r109", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 109", "refseq_ac": [ { "id": "NP_996900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996900", "type": "external" } ], "gene_names_uniprotkb": "Tas2r109; T2r62", "gene_names_refseq": "T2R09; Tas2r109; Tas2r9; mGR09; mt2r62", "protein_names_uniprotkb": "Taste receptor type 2 member 109; T2R109; mT2R62", "protein_names_refseq": "T2R109; taste receptor type 2 member 109", "tax_id": 10090, "disease": "", "pathway": " (mmu:387343)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12679530", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7M707-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7M709-1", "uniprot_id": [ { "id": "TR129_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7M709", "type": "external" } ], "mass": 37178.0, "length": 320, "protein_name": "Taste receptor type 2 member 129", "gene_name": "Tas2r129", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 129", "refseq_ac": [ { "id": "NP_996912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996912", "type": "external" } ], "gene_names_uniprotkb": "Tas2r129; T2r60", "gene_names_refseq": "T2R29; Tas2r129; Tas2r29; mGR29; mt2r60", "protein_names_uniprotkb": "Taste receptor type 2 member 129; T2R129; mT2R60", "protein_names_refseq": "T2R129; taste receptor type 2 member 129", "tax_id": 10090, "disease": "", "pathway": " (mmu:387354)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12679530", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7M709-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7M715-1", "uniprot_id": [ { "id": "TR117_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7M715", "type": "external" } ], "mass": 38528.0, "length": 330, "protein_name": "Taste receptor type 2 member 117", "gene_name": "Tas2r117", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 117", "refseq_ac": [ { "id": "NP_996904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996904", "type": "external" } ], "gene_names_uniprotkb": "Tas2r117; 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T2r64; Tas2r137; Tas2r13; Tas2r40; Tas2r8", "gene_names_refseq": "T2R40; T2r34; TRB3; TRB5; Tas2r137; Tas2r13; Tas2r140; Tas2r40; Tas2r8; mTRB3; mt2r64", "protein_names_uniprotkb": "Taste receptor type 2 member 140; T2R13; T2R140; T2R40; T2R8; Taste receptor family B member 3; Taste receptor type 2 member 40; mT2r64; mTRB3; mTRB5", "protein_names_refseq": "T2R13; T2R140; T2R8; mTRB5; taste receptor family B member 3; taste receptor type 2 member 140; taste receptor type 2 member 40", "tax_id": 10090, "disease": "", "pathway": " (mmu:387616); (R-MMU-418594); (R-MMU-420499); (R-MMU-9717207)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10766242;11696554;12139982;12581520;12679530;12734386", "class_list": "", "function": "Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A6H6Q9;Q9JKA0;Q9JKA2", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7TQA4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQA9-1", "uniprot_id": [ { "id": "TR135_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQA9", "type": "external" } ], "mass": 35591.0, "length": 312, "protein_name": "Taste receptor type 2 member 135", "gene_name": "Tas2r135", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 135", "refseq_ac": [ { "id": "NP_954610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954610", "type": "external" } ], "gene_names_uniprotkb": "Tas2r135; T2r38; Tas2r35", "gene_names_refseq": "Tas2r135; Tas2r35; mt2r38", "protein_names_uniprotkb": "Taste receptor type 2 member 135; T2R135; T2R35; Taste receptor type 2 member 35; mT2r38", "protein_names_refseq": "T2R135; T2R35; taste receptor type 2 member 135; taste receptor type 2 member 35", "tax_id": 10090, "disease": "", "pathway": " (mmu:387512); (R-MMU-418594); (R-MMU-420499)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12679530;12734386;26692363;33559206", "class_list": "", "function": "Genetic deletion of the Tas2r143/Tas2r135/Tas2r126 cluster reveals that TAS2Rs may not mediate bitter tastant-induced bronchodilation., [RefSeq, PubMed]; Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB, PubMed]; The role of Tas2R135 in the development of obesity and adipocyte metabolism Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4FUQ3;Q7M705", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7TQA9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQB0-1", "uniprot_id": [ { "id": "TR134_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQB0", "type": "external" } ], "mass": 34628.0, "length": 298, "protein_name": "Taste receptor type 2 member 134", "gene_name": "Tas2r134", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 134", "refseq_ac": [ { "id": "NP_954609", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954609", "type": "external" } ], "gene_names_uniprotkb": "Tas2r134; Tas2r34", "gene_names_refseq": "T2R134; Tas2r134; Tas2r34", "protein_names_uniprotkb": "Taste receptor type 2 member 134; T2R134; T2R34; Taste receptor type 2 member 34", "protein_names_refseq": "T2R34; taste receptor type 2 member 134; taste receptor type 2 member 34", "tax_id": 10090, "disease": "", "pathway": " (mmu:387511)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12734386;15886333", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4VHF1", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7TQB0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQB9-1", "uniprot_id": [ { "id": "TR143_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQB9", "type": "external" } ], "mass": 34045.0, "length": 293, "protein_name": "Taste receptor type 2 member 143", "gene_name": "Tas2r143", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 143", "refseq_ac": [ { "id": "NP_001001452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001452", "type": "external" } ], "gene_names_uniprotkb": "Tas2r143; T2r36; Tas2r43", "gene_names_refseq": "Gm1404; Tas2r143; Tas2r43; mt2r36", "protein_names_uniprotkb": "Taste receptor type 2 member 143; T2R143; T2R43; Taste receptor type 2 member 43; mT2R36", "protein_names_refseq": "T2R143; T2R43; taste receptor type 2 member 143; taste receptor type 2 member 43", "tax_id": 10090, "disease": "", "pathway": " (mmu:387514)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12679530;12734386;25428506;33300544;33559206;36059440", "class_list": "", "function": "Genetic deletion of the Tas2r143/Tas2r135/Tas2r126 cluster reveals that TAS2Rs may not mediate bitter tastant-induced bronchodilation., [RefSeq, PubMed]; Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB, PubMed]; Tas2R signaling enhances mouse neutrophil migration via a ROCK-dependent pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A7MAX5;Q2NL43", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7TQB9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQD2-1", "uniprot_id": [ { "id": "TPPP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQD2", "type": "external" } ], "mass": 23575.0, "length": 218, "protein_name": "Tubulin polymerization-promoting protein", "gene_name": "Tppp", "organism": "Mouse", "refseq_name": "tubulin polymerization-promoting protein", "refseq_ac": [ { "id": "NP_878259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_878259", "type": "external" } ], "gene_names_uniprotkb": "Tppp", "gene_names_refseq": "2900041A09Rik; TPPP/p25; Tppp", "protein_names_uniprotkb": "Tubulin polymerization-promoting protein; 25 kDa brain-specific protein; 3.6.5.-; TPPP/p25; TPPP; p25-alpha", "protein_names_refseq": "25 kDa brain-specific protein; brain-specific protein p25 alpha; p25-alpha; tubulin polymerization-promoting protein", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:72948)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "16452087;16452088;18028908;21158410;21183079;22645316;26192747;31522887;32848054;33300544;33978813;35822049;37507487;40021952;40885482", "class_list": "", "function": "In vivo impact of tubulin polymerization promoting protein (Tppp) knockout to the airway inflammatory response. Publication Status: Online-Only, [RefSeq, PubMed]; LIMK1 phosphorylation of p25 blocks p25 activity, thus promoting microtubule disassembly., [RefSeq, PubMed]; Multiple system atrophy-associated oligodendroglial protein p25alpha stimulates formation of novel alpha-synuclein strain with enhanced neurodegenerative potential., [RefSeq, PubMed]; Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed:31522887). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed:31522887). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (By similarity). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed:18028908). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (By similarity). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (By similarity). Plays a role in cell proliferation by regulating the G1/S-phase transition (By similarity). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; These results demonstrate that TPPP on Golgi outposts are important for local microtubule nucleation and myelin sheath elongation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0008017 microtubule binding;GO:0042803 protein homodimerization activity;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0051301 cell division;GO:0031334 positive regulation of protein-containing complex assembly;GO:0014003 oligodendrocyte development;GO:0032288 myelin assembly", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q7TQD2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZI1-1", "uniprot_id": [ { "id": "TRNP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80ZI1", "type": "external" } ], "mass": 23086.0, "length": 223, "protein_name": "TMF-regulated nuclear protein 1", "gene_name": "Trnp1", "organism": "Mouse", "refseq_name": "TMF-regulated nuclear protein 1", "refseq_ac": [ { "id": "NP_001074625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074625", "type": "external" } ], "gene_names_uniprotkb": "Trnp1; Trnp", "gene_names_refseq": "2300002D11Rik; Trnp1; Trnp", "protein_names_uniprotkb": "TMF-regulated nuclear protein 1", "protein_names_refseq": "TMF-regulated nuclear protein 1; mexneurin", "tax_id": 10090, "disease": "", "pathway": " (mmu:69539)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16792503;23622239;28504339;32627867;36947129", "class_list": "", "function": "DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Regulates neural stem cells proliferation and the production of intermediate neural progenitors and basal radial glial cells affecting the process of cerebral cortex gyrification. May control the proliferation rate of cells by regulating their progression through key cell-cycle transition points., [UniProtKB, PubMed, PubMed]; Data suggest that neurons in mouse brain exhibit DNA sequence encoding protein precursor, proMexneurin, that contains three peptide sequences: Mexneurin-1 (an endomorphin1-like peptide), Mexneurin-2 (an endomorphin1-like peptide), and Mexneurin-3 (peptide which appears to be unrelated to endomorphins); neurons exhibit expression of proMexneurin mRNA throughout mouse brain., [RefSeq, PubMed]; Regulatory and coding sequences of TRNP1 co-evolve with brain size and cortical folding in mammals. Publication Status: Online-Only, [RefSeq, PubMed]; Study identified Trnp1 as a regulator of mammalian brain development and as a key factor controlling neocortical expansion. Trnp1 levels have striking effects on tangential, radial, and lateral expansion of the cerebral cortex., [RefSeq, PubMed]; Trnp1 organizes diverse nuclear membrane-less compartments in neural stem cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021696 cerebellar cortex morphogenesis;GO:0006351 DNA-templated transcription;GO:0042127 regulation of cell population proliferation;GO:0061351 neural precursor cell proliferation;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80ZI1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BV79-1", "uniprot_id": [ { "id": "TRNK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BV79", "type": "external" } ], "mass": 343320.0, "length": 2999, "protein_name": "TPR and ankyrin repeat-containing protein 1", "gene_name": "Trank1", "organism": "Mouse", "refseq_name": "TPR and ankyrin repeat-containing protein 1", "refseq_ac": [ { "id": "NP_001158131", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158131", "type": "external" } ], "gene_names_uniprotkb": "Trank1; Gm187; Kiaa0342; Lba1", "gene_names_refseq": "A230061D21Rik; C030048J01Rik; Gm187; Lba1; Trank1", "protein_names_uniprotkb": "TPR and ankyrin repeat-containing protein 1; Lupus brain antigen 1", "protein_names_refseq": "TPR and ankyrin repeat-containing protein 1; lupus brain antigen 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:320429)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;9585807", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5RJH5;Q6ZQD5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BV79-1", "record_type": "protein", "filter_code": "0000000.1000101.001000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0D0-1", "uniprot_id": [ { "id": "TRUB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0D0", "type": "external" } ], "mass": 36348.0, "length": 338, "protein_name": "Pseudouridylate synthase TRUB1", "gene_name": "Trub1", "organism": "Mouse", "refseq_name": "pseudouridylate synthase TRUB1 isoform 1", "refseq_ac": [ { "id": "NP_082391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082391", "type": "external" } ], "gene_names_uniprotkb": "Trub1", "gene_names_refseq": "2610009I02Rik; 9030425C13Rik; Trub1", "protein_names_uniprotkb": "Pseudouridylate synthase TRUB1; 5.4.99.-; 5.4.99.25; Psi55 synthase TRUB1; TruB pseudouridine synthase homolog 1; tRNA pseudouridine 55 synthase TRUB1", "protein_names_refseq": "TruB pseudouridine (psi) synthase homolog 1; probable tRNA pseudouridine synthase 1; pseudouridylate synthase TRUB1 isoform 1; pseudouridylate synthase TRUB1; psi55 synthase TRUB1; tRNA pseudouridine 55 synthase TRUB1; truB pseudouridine synthase homolog 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72133)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs. Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure. Constitutes the major pseudouridine synthase acting on mRNAs. Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs. Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity. Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBH7;Q9D331", "ec_number_list": [ { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" }, { "id": "5.4.99.42", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.42", "type": "external" }, { "id": "5.4.99.28", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.28", "type": "external" }, { "id": "5.4.99.25", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.25", "type": "external" }, { "id": "5.4.99.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.12", "type": "external" } ], "go_molecular_function": "GO:0009982 pseudouridine synthase activity;GO:0070883 pre-miRNA binding;GO:0160148 tRNA pseudouridine(55) synthase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0031119 tRNA pseudouridine synthesis;GO:0006397 mRNA processing;GO:0006400 tRNA modification;GO:1990481 mRNA pseudouridine synthesis;GO:2000633 positive regulation of pre-miRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C0D0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0S4-1", "uniprot_id": [ { "id": "TT21A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0S4", "type": "external" } ], "mass": 148617.0, "length": 1314, "protein_name": "Tetratricopeptide repeat protein 21A", "gene_name": "Ttc21a", "organism": "Mouse", "refseq_name": "tetratricopeptide repeat protein 21A", "refseq_ac": [ { "id": "NP_083011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083011", "type": "external" } ], "gene_names_uniprotkb": "Ttc21a; Thm2", "gene_names_refseq": "4921538N17Rik; Thm2; Ttc21a", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 21A; TPR repeat protein 21A; Tetratricopeptide repeat-containing hedgehog modulator 2", "protein_names_refseq": "TPR repeat protein 21A; tetratricopeptide repeat protein 21A; tetratricopeptide repeat-containing hedgehog modulator 2", "tax_id": 10090, "disease": "spermatogenic failure 37 (Disease Ontology:DOID:0111927); nephronophthisis (Disease Ontology:DOID:12712)", "pathway": " (mmu:74052)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17971504;30929735;33683377;40021952", "class_list": "", "function": "Bi-allelic mutations in TTC21A can induce asthenoteratospermia with defects of the sperm flagella and head-tail conjunction, [RefSeq, PubMed]; Intraflagellar transport (IFT)-associated protein required for spermatogenesis (PubMed:30929735). Required for sperm flagellar formation and intraflagellar transport (PubMed:30929735)., [UniProtKB, PubMed]; Thm2 interacts with paralog, Thm1, and sensitizes to Hedgehog signaling in postnatal skeletogenesis., [RefSeq, PubMed]; Ttc21a is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0HA37;Q3V0A2;Q9D5Q9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0030991 intraciliary transport particle A", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0007286 spermatid development;GO:0061512 protein localization to cilium;GO:0035721 intraciliary retrograde transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8C0S4-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CE96-1", "uniprot_id": [ { "id": "TRM6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CE96", "type": "external" } ], "mass": 55518.0, "length": 497, "protein_name": "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "gene_name": "Trmt6", "organism": "Mouse", "refseq_name": "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform 1", "refseq_ac": [ { "id": "NP_780322", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780322", "type": "external" } ], "gene_names_uniprotkb": "Trmt6; Kiaa1153; Trm6", "gene_names_refseq": "3300001M20Rik; CGI-09; Trmt6; mKIAA1153", "protein_names_uniprotkb": "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6; tRNA(m1A58)-methyltransferase subunit TRM6; tRNA(m1A58)MTase subunit TRM6", "protein_names_refseq": "mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6; tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform 1; tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; tRNA (adenine-N(1)-)-methyltransferase non-catalytic subunit TRM6; tRNA methyltransferase 6 homolog; tRNA(m1A58)-methyltransferase subunit TRM6; tRNA(m1A58)MTase subunit TRM6", "tax_id": 10090, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:66926)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17525332;34428180", "class_list": "", "function": "Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJZ8;Q3TME7;Q6ZPW8;Q80Y59;Q8CEU0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031515 tRNA (m1A) methyltransferase complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0030488 tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CE96-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CIR4-1", "uniprot_id": [ { "id": "TRPM6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CIR4", "type": "external" } ], "mass": 232888.0, "length": 2028, "protein_name": "Transient receptor potential cation channel subfamily M member 6", "gene_name": "Trpm6", "organism": "Mouse", "refseq_name": "transient receptor potential cation channel subfamily M member 6", "refseq_ac": [ { "id": "NP_700466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_700466", "type": "external" } ], "gene_names_uniprotkb": "Trpm6", "gene_names_refseq": "CHAK2; TRPM6/CHAK2; Trpm6", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily M member 6; 2.7.11.1; Channel kinase 2; Melastatin-related TRP cation channel 6", "protein_names_refseq": "melastatin-related TRP cation channel 6; putative cation channel subfamily M member 6; transient receptor potential cation channel 6/channel-kinase 2; transient receptor potential cation channel subfamily M member 6", "tax_id": 10090, "disease": "chromosome 15q13.3 microdeletion syndrome (Disease Ontology:DOID:0060394); intestinal hypomagnesemia 1 (Disease Ontology:DOID:0060883); metal metabolism disorder (Disease Ontology:DOID:896)", "pathway": " (mmu:225997); (R-MMU-3295583)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "18385471;19692351;20173027;21750661;27991852;28821869;34140503", "class_list": "", "function": "Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain (PubMed:27991852, PubMed:28821869). Crucial for Mg(2+) homeostasis. Has an important role in epithelial magnesium transport and in the active Mg(2+) absorption in the gut and kidney (PubMed:27991852). However, whether TRPM6 forms functional homomeric channels by itself or functions primarily as a subunit of heteromeric TRPM6-TRPM7 channels, is still under debate (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure. Publication Status: Online-Only, [RefSeq, PubMed]; In C57BL/6J mice, dietary Mg(2+)-restriction results in increased Mg(2+) (re)absorption, which is correlated with increased TRPM6 expression., [RefSeq, PubMed]; The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and development., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A1W5LU38", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005262 calcium channel activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane;GO:0016020 membrane", "go_biological_process": "GO:1903830 magnesium ion transmembrane transport;GO:0051262 protein tetramerization;GO:0006816 calcium ion transport;GO:0098655 monoatomic cation transmembrane transport;GO:0009636 response to toxic substance", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8CIR4-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1J6-1", "uniprot_id": [ { "id": "TRNT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1J6", "type": "external" } ], "mass": 49895.0, "length": 434, "protein_name": "CCA tRNA nucleotidyltransferase 1, mitochondrial", "gene_name": "Trnt1", "organism": "Mouse", "refseq_name": "CCA tRNA nucleotidyltransferase 1, mitochondrial isoform a", "refseq_ac": [ { "id": "NP_001229287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229287", "type": "external" } ], "gene_names_uniprotkb": "Trnt1", "gene_names_refseq": "2410043H24Rik; 2610044E04Rik; 9830143O18Rik; CGI-47; Trnt1; mt-Trat", "protein_names_uniprotkb": "CCA tRNA nucleotidyltransferase 1, mitochondrial; 2.7.7.72; mitochondrial tRNA nucleotidyl transferase, CCA-adding; mt CCA-adding enzyme; mt tRNA CCA-diphosphorylase; mt tRNA CCA-pyrophosphorylase; mt tRNA adenylyltransferase", "protein_names_refseq": "CCA tRNA nucleotidyltransferase 1, mitochondrial isoform a; CCA tRNA nucleotidyltransferase 1, mitochondrial; mitochondrial tRNA nucleotidyl transferase, CCA-adding; mt CCA-adding enzyme; mt tRNA CCA-diphosphorylase; mt tRNA CCA-pyrophosphorylase; mt tRNA adenylyltransferase; tRNA adenylyltransferase, mitochondrial; tRNA-nucleotidyltransferase 1, mitochondrial", "tax_id": 10090, "disease": "sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay (Disease Ontology:DOID:0080209); sideroblastic anemia (Disease Ontology:DOID:8955)", "pathway": " (mmu:70047)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11504732;21750661;23806337;30084848;30779550;34428180", "class_list": "", "function": "Nucleotidyltransferase that catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs, which is necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Promotes tRNA repair and recycling downstream of the ribosome-associated quality control (RQC) pathway by mediating addition of the tRNA 3'-terminal CCA following cleavage by ANKZF1 and repair by ELAC1. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs and tRNA-like transcripts. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs beginning with GG are marked with CCACCA and rapidly degraded. The structural flexibility of RNA controls the choice between CCA versus CCACCA addition: following the first CCA addition cycle, nucleotide-binding to the active site triggers a clockwise screw motion, producing torque on the RNA. This ejects stable RNAs, whereas unstable RNAs are refolded while bound to the enzyme and subjected to a second CCA catalytic cycle., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKW1;Q3UX99;Q920N6;Q9CSX0", "ec_number_list": [ { "id": "2.7.7.72", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.72", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0000049 tRNA binding;GO:0004810 CCA tRNA nucleotidyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:1902494 catalytic complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0008033 tRNA processing;GO:0001680 tRNA 3'-terminal CCA addition;GO:1990180 mitochondrial tRNA 3'-end processing;GO:0106354 tRNA surveillance", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K1J6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8QZR0-1", "uniprot_id": [ { "id": "TR1L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8QZR0", "type": "external" } ], "mass": 40983.0, "length": 363, "protein_name": "Translocating chain-associated membrane protein 1-like 1", "gene_name": "Tram1l1", "organism": "Mouse", "refseq_name": "translocating chain-associated membrane protein 1-like 1", "refseq_ac": [ { "id": "NP_666252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666252", "type": "external" } ], "gene_names_uniprotkb": "Tram1l1", "gene_names_refseq": "A830091N21Rik; Tram1l1", "protein_names_uniprotkb": "Translocating chain-associated membrane protein 1-like 1", "protein_names_refseq": "translocating chain-associated membrane protein 1-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:229801)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Stimulatory or required for the translocation of secretory proteins across the ER membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C455;Q8C6X6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045048 protein insertion into ER membrane;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8QZR0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4D5-1", "uniprot_id": [ { "id": "TRPM8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R4D5", "type": "external" } ], "mass": 127710.0, "length": 1104, "protein_name": "Transient receptor potential cation channel subfamily M member 8", "gene_name": "Trpm8", "organism": "Mouse", "refseq_name": "transient receptor potential cation channel subfamily M member 8", "refseq_ac": [ { "id": "NP_599013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599013", "type": "external" } ], "gene_names_uniprotkb": "Trpm8; Ltrpc6; Trpp8", "gene_names_refseq": "CMR1; LTRPC6; LTrpC-6; TRPP8; Trp-p8; Trpm8", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily M member 8; LTrpC-6; LTrpC6; Long transient receptor potential channel 6; Transient receptor potential p8; Trp-p8", "protein_names_refseq": "TRP ion channel TRPM8; long transient receptor potential channel 6; transient receptor potential cation channel subfamily M member 8; transient receptor potential p8", "tax_id": 10090, "disease": "", "pathway": " (mmu:171382); (R-MMU-3295583)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11893340;12654248;15190109;17015441;17481391;19176480;22493431;25998021;35662242;36227998", "class_list": "", "function": "Non-selective ion channel permeable to monovalent and divalent cations, including Na(+), K(+), and Ca(2+), with higher permeability for Ca(2+) (PubMed:11893340, PubMed:12654248, PubMed:15190109). Activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality (PubMed:12654248, PubMed:15190109, PubMed:25998021). Activated by cool temperatures (<23-28 degrees Celsius) and by chemical ligands evoking a sensation of coolness, such as menthol and icilin, therefore plays a central role in the detection of environmental cold temperatures (PubMed:12654248, PubMed:15190109, PubMed:17481391). TRPM8 is a voltage-dependent channel; its activation by cold or chemical ligands shifts its voltage thresholds towards physiological membrane potentials, leading to the opening of the channel (By similarity). In addition to its critical role in temperature sensing, regulates basal tear secretion by sensing evaporation-induced cooling and changes in osmolality (PubMed:25998021)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9Q165;Q148W9", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0005262 calcium channel activity;GO:0042802 identical protein binding;GO:0099604 ligand-gated calcium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0044853 plasma membrane raft;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0009409 response to cold;GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0009266 response to temperature stimulus;GO:0070588 calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8R4D5-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1000100000000.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4U6-1", "uniprot_id": [ { "id": "TOP1M_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R4U6", "type": "external" } ], "mass": 69003.0, "length": 593, "protein_name": "DNA topoisomerase I, mitochondrial", "gene_name": "Top1mt", "organism": "Mouse", "refseq_name": "DNA topoisomerase I, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_082680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082680", "type": "external" } ], "gene_names_uniprotkb": "Top1mt", "gene_names_refseq": "2900052H09Rik; Top1mt", "protein_names_uniprotkb": "DNA topoisomerase I, mitochondrial; 5.6.2.1; TOP1mt", "protein_names_refseq": "DNA topoisomerase I, mitochondrial isoform 1; DNA topoisomerase I, mitochondrial; mitochondrial topoisomerase I", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:72960)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15096574;29021209;30622257;35820727;37129502", "class_list": "", "function": "Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT., [RefSeq, PubMed]; Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)., [UniProtKB]; Study demonstrated that lack of TOP1MT results in delayed and decreased tumor growth due to impaired mitochondrial translation. The TOP1MT genomic signature profile, based on mouse model for Top1mt-KO liver cancers, is correlated with enhanced survival of hepatocellular carcinoma patients. Publication Status: Online-Only, [RefSeq, PubMed]; TOP1MT acts as a topological barrier and regulator for mtDNA transcription and D-loop formation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid;GO:0005694 chromosome", "go_biological_process": "GO:0006260 DNA replication;GO:0006265 DNA topological change", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R4U6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VD63-1", "uniprot_id": [ { "id": "TSYL4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VD63", "type": "external" } ], "mass": 44811.0, "length": 406, "protein_name": "Testis-specific Y-encoded-like protein 4", "gene_name": "Tspyl4", "organism": "Mouse", "refseq_name": "testis-specific Y-encoded-like protein 4", "refseq_ac": [ { "id": "NP_084479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084479", "type": "external" } ], "gene_names_uniprotkb": "Tspyl4; D10Bwg0791e", "gene_names_refseq": "2610102M01Rik; B230210I21Rik; D10Bwg0791e; Tspyl4", "protein_names_uniprotkb": "Testis-specific Y-encoded-like protein 4; TSPY-like protein 4", "protein_names_refseq": "TSPY-like protein 4; testis-specific Y-encoded-like protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:72480)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17114649", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VD63-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CY00-1", "uniprot_id": [ { "id": "IT70B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CY00", "type": "external" } ], "mass": 76096.0, "length": 664, "protein_name": "Intraflagellar transport protein 70B", "gene_name": "Ift70b", "organism": "Mouse", "refseq_name": "intraflagellar transport protein 70B", "refseq_ac": [ { "id": "NP_082511", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082511", "type": "external" } ], "gene_names_uniprotkb": "Ift70b; Ttc30b", "gene_names_refseq": "2510042P03Rik; Ift70b; Tcc30b; Ttc30b", "protein_names_uniprotkb": "Intraflagellar transport protein 70B; TPR repeat protein 30B; Tetratricopeptide repeat protein 30B", "protein_names_refseq": "TPR repeat protein 30B; intraflagellar transport protein 70B; novel tetratrico peptide repeat (TPR) containing protein; tetratricopeptide repeat domain 30B; tetratricopeptide repeat protein 30B", "tax_id": 10090, "disease": "", "pathway": " (mmu:72421); (R-MMU-5620924)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "23810713;25428506;30084848;34428180", "class_list": "", "function": "Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UI02", "ec_number_list": [], "go_molecular_function": "GO:0120170 intraciliary transport particle B binding", "go_cellular_component": "GO:0005929 cilium;GO:0036064 ciliary basal body;GO:0005879 axonemal microtubule;GO:0030992 intraciliary transport particle B", "go_biological_process": "GO:0060271 cilium assembly;GO:0042073 intraciliary transport;GO:0035720 intraciliary anterograde transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CY00-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CYB0-1", "uniprot_id": [ { "id": "TRI13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CYB0", "type": "external" } ], "mass": 46958.0, "length": 407, "protein_name": "E3 ubiquitin-protein ligase TRIM13", "gene_name": "Trim13", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase TRIM13", "refseq_ac": [ { "id": "NP_001157692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157692", "type": "external" } ], "gene_names_uniprotkb": "Trim13; Rfp2", "gene_names_refseq": "3110001L12Rik; CAR; LEU5; RNF77; Rfp2; Trim13", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM13; 2.3.2.27; Putative tumor suppressor RFP2; RING-type E3 ubiquitin transferase TRIM13; Ret finger protein 2; Tripartite motif-containing protein 13", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM13; RING-type E3 ubiquitin transferase TRIM13; putative tumor suppressor RFP2; ret finger protein 2; tripartite motif protein 13; tripartite motif-containing protein 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:66597)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11161783;11331580;31219806;32446357;35080984;37205848;38537695", "class_list": "", "function": "Brain-specific deletion of TRIM13 promotes metabolic stress-triggered insulin resistance, glucose intolerance, and neuroinflammation., [RefSeq, PubMed]; Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor. Also plays a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation. Participates as well in T-cell receptor-mediated NF-kappa-B activation. In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B., [UniProtKB, UniProtKB]; Repression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development., [RefSeq, PubMed]; TRIM13 reduces cholesterol efflux and increases oxidized LDL uptake leading to foam cell formation and atherosclerosis., [RefSeq, PubMed]; The transmembrane endoplasmic reticulum-associated E3 ubiquitin ligase TRIM13 restrains the pathogenic-DNA-triggered inflammatory response., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6H6L2;Q8CEV0;Q923J0;Q925P1;Q99PQ0", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0061659 ubiquitin-like protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0097038 perinuclear endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:0044790 suppression of viral release by host;GO:0045087 innate immune response;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9CYB0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8Z2-1", "uniprot_id": [ { "id": "TRIA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8Z2", "type": "external" } ], "mass": 8756.0, "length": 76, "protein_name": "TP53-regulated inhibitor of apoptosis 1", "gene_name": "Triap1", "organism": "Mouse", "refseq_name": "TP53-regulated inhibitor of apoptosis 1", "refseq_ac": [ { "id": "NP_081209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081209", "type": "external" } ], "gene_names_uniprotkb": "Triap1; 15e1.1", "gene_names_refseq": "1810015M01Rik; P53csv; Triap1; Wf-1", "protein_names_uniprotkb": "TP53-regulated inhibitor of apoptosis 1; Protein 15E1.1; WF-1; p53-inducible cell-survival factor; p53CSV", "protein_names_refseq": "TP53-regulated inhibitor of apoptosis 1; p53-inducible cell-survival factor; protein 15E1.1", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": " (mmu:69076); (R-MMU-6803204)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "38157298", "class_list": "", "function": "CHCHD4-TRIAP1 regulation of innate immune signaling mediates skeletal muscle adaptation to exercise., [RefSeq, PubMed]; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6LCG5", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" } ], "go_molecular_function": "GO:1990050 phosphatidic acid transfer activity;GO:0002039 p53 binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:0015914 phospholipid transport;GO:0090201 negative regulation of release of cytochrome c from mitochondria", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D8Z2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DA44-1", "uniprot_id": [ { "id": "TSACC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DA44", "type": "external" } ], "mass": 13476.0, "length": 124, "protein_name": "TSSK6-activating co-chaperone protein", "gene_name": "Tsacc", "organism": "Mouse", "refseq_name": "TSSK6-activating co-chaperone protein", "refseq_ac": [ { "id": "NP_084077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084077", "type": "external" } ], "gene_names_uniprotkb": "Tsacc", "gene_names_refseq": "1700021C14Rik; SIP; Tsacc", "protein_names_uniprotkb": "TSSK6-activating co-chaperone protein", "protein_names_refseq": "TSSK6-activating co-chaperone protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:76927)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20829357;31219806", "class_list": "", "function": "Co-chaperone that facilitates HSP-mediated activation of TSSK6., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051087 protein-folding chaperone binding;GO:0004860 protein kinase inhibitor activity;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0045860 positive regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DA44-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCG9-1", "uniprot_id": [ { "id": "TR112_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCG9", "type": "external" } ], "mass": 14141.0, "length": 125, "protein_name": "Multifunctional methyltransferase subunit TRM112-like protein", "gene_name": "Trmt112", "organism": "Mouse", "refseq_name": "multifunctional methyltransferase subunit TRM112-like protein", "refseq_ac": [ { "id": "NP_001159842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159842", "type": "external" } ], "gene_names_uniprotkb": "Trmt112", "gene_names_refseq": "0610038D11Rik; Trm112p; Trmt112", "protein_names_uniprotkb": "Multifunctional methyltransferase subunit TRM112-like protein; tRNA methyltransferase 112 homolog", "protein_names_refseq": "TRM112-like protein; multifunctional methyltransferase subunit TRM112-like protein; tRNA methyltransferase 11-2 homolog; tRNA methyltransferase 112 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67674); (R-MMU-156581); (R-MMU-72764)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "20606008;26797129;31599954;34669960", "class_list": "", "function": "Acts as an activator of both rRNA/tRNA and protein methyltransferases (PubMed:20606008, PubMed:26797129). Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA (By similarity). The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor (PubMed:20606008, PubMed:26797129). The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (By similarity). Together with methyltransferase THUMPD3, catalyzes the formation of N(2)-methylguanosine at position 6 in a broad range of tRNA substrates and at position 7 of tRNA(Trp) (By similarity). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production (By similarity). Together with methyltransferase METTL5, specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91YP8;Q9D1N6", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0008276 protein methyltransferase activity;GO:0141106 tRNA methyltransferase activator activity", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0031167 rRNA methylation;GO:0070476 rRNA (guanine-N7)-methylation;GO:2000234 positive regulation of rRNA processing;GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0002098 tRNA wobble uridine modification", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DCG9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPU5-1", "uniprot_id": [ { "id": "TNR21_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EPU5", "type": "external" } ], "mass": 71983.0, "length": 655, "protein_name": "Tumor necrosis factor receptor superfamily member 21", "gene_name": "Tnfrsf21", "organism": "Mouse", "refseq_name": "tumor necrosis factor receptor superfamily member 21 precursor", "refseq_ac": [ { "id": "NP_848704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848704", "type": "external" } ], "gene_names_uniprotkb": "Tnfrsf21; Dr6", "gene_names_refseq": "DR6; TR7; Tnfrsf21", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 21; Death receptor 6", "protein_names_refseq": "Death receptor 6; TNFR-related death receptor-6; tumor necrosis factor receptor superfamily member 21 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:94185)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11485735;11714751;12244201;12515813;19225519;21725297;23559013;31219806;34012073;38110576;38609388", "class_list": "", "function": "Endothelial DR6 in blood-brain barrier malfunction in Alzheimer's disease. Publication Status: Online-Only, [RefSeq, PubMed]; Enhanced B cell expansion, survival, and humoral responses by targeting death receptor 6., [RefSeq, PubMed]; Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B (PubMed:11485735, PubMed:11714751, PubMed:12515813, PubMed:21725297, PubMed:23559013). Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm (By similarity). Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP) (PubMed:23559013). Negatively regulates oligodendrocyte survival, maturation and myelination (PubMed:21725297). Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation (By similarity). Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells (By similarity). Negatively regulates the production of IgG, IgM and IgM in response to antigens (By similarity). May inhibit the activation of JNK in response to T-cell stimulation (By similarity). Also acts as a regulator of pyroptosis: recruits CASP8 in response to reactive oxygen species (ROS) and subsequent oxidation, leading to activation of GSDMC (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; T cells lacking the DR6 receptor generate a severe form of acute graft-versus-host disease with accelerated onset, increased severity, rapid weight loss, and earlier organ damage and mortality., [RefSeq, PubMed]; The metabolite alpha-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3UYG3;Q543Y9;Q91W77;Q91XH9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0032693 negative regulation of interleukin-10 production;GO:0032714 negative regulation of interleukin-5 production;GO:0051402 neuron apoptotic process;GO:0006915 apoptotic process;GO:0042130 negative regulation of T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9EPU5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJH7-1", "uniprot_id": [ { "id": "TRPM5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJH7", "type": "external" } ], "mass": 130844.0, "length": 1158, "protein_name": "Transient receptor potential cation channel subfamily M member 5", "gene_name": "Trpm5", "organism": "Mouse", "refseq_name": "transient receptor potential cation channel subfamily M member 5", "refseq_ac": [ { "id": "NP_064673", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064673", "type": "external" } ], "gene_names_uniprotkb": "Trpm5; Ltrpc5; Mtr1", "gene_names_refseq": "9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1; Trpm5", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily M member 5; LTrpC-5; LTrpC5; Long transient receptor potential channel 5; MLSN1- and TRP-related gene 1 protein", "protein_names_refseq": "MLSN1- and TRP-related gene 1 protein; long transient receptor potential channel 5; long transient receptor potential-related channel 5; transient receptor potential cation channel subfamily M member 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:56843); (R-MMU-3295583)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10903843;10907850;10915772;12368808;12842017;14657398;15670874;15731110;16355226;16436689;16935556;17267604;17522321;17610722;20194741;20393858;21750661;38538847", "class_list": "", "function": "Monovalent cation-selective ion channel activated by intracellular Ca(2+) in a voltage- and temperature-dependent manner (PubMed:12842017, PubMed:14657398, PubMed:17522321, PubMed:38538847). Mediates the transport of Na(+), K(+) and Cs(+) ions equally well (PubMed:12842017). Activated directly by increase in intracellular Ca(2+), but is impermeable to it (PubMed:12842017). The activation mechanism of TRPM5 involves a multistep process. TRPM5 activation involves ligand binding (i.e., tastant molecule, glucose stimulation) to Gq/G protein-coupled receptors (GPCR) and leads to the breakdown of phosphatidylinositol bisphosphate (PIP2) into diacylglycerol (DAG) and inositol trisphosphate (IP3), IP3 binds to its receptors in the endoplasmic reticulum and cause Ca(2+) release. Simultaneously with the intracellular Ca(2+) release, DAG activates the protein kinase C (PKC), which phosphorylates the TRPM5 channel. This phosphorylation combined with the bound Ca(2+), leads to a robust inward current allowing the entry of sodium ions (Na+) into the cell. This ion influx depolarizes the cell membrane, generating action potentials that propagate TRPM5 signals. Is a key player in sensing sweet, umami and bitter stimuli (Probable) (PubMed:16436689, PubMed:16935556). May also be involved in sensing semiochemicals (PubMed:17267604). Involved in insulin secretion by pancreatic beta cells (PubMed:20194741, PubMed:20393858)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KN89;Q3TU14;Q7TPL4;Q99NF9;Q9EPM3;Q9EPM4", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0005267 potassium channel activity;GO:0005227 calcium-activated cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0034220 monoatomic ion transmembrane transport;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0098655 monoatomic cation transmembrane transport;GO:0030001 metal ion transport", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9JJH7-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKA3-1", "uniprot_id": [ { "id": "TR103_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKA3", "type": "external" } ], "mass": 35156.0, "length": 312, "protein_name": "Taste receptor type 2 member 103", "gene_name": "Tas2r103", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 103", "refseq_ac": [ { "id": "NP_444441", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444441", "type": "external" } ], "gene_names_uniprotkb": "Tas2r103; Tas2r10", "gene_names_refseq": "EG667992; T2R3; TRB2; Tas2r103; Tas2r10; Tas2r3; mGR03; mt2r63", "protein_names_uniprotkb": "Taste receptor type 2 member 103; T2R103; T2R10; TRB2; Taste receptor family B member 2; Taste receptor type 2 member 10", "protein_names_refseq": "T2R103; T2R10; taste receptor family B member 2; taste receptor type 2 member 103; taste receptor type 2 member 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:667992)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10766242;11696554;12139982;12581520;12679530", "class_list": "", "function": "Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7M706", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JKA3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKE2-1", "uniprot_id": [ { "id": "TREM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKE2", "type": "external" } ], "mass": 25409.0, "length": 230, "protein_name": "Triggering receptor expressed on myeloid cells 1", "gene_name": "Trem1", "organism": "Mouse", "refseq_name": "triggering receptor expressed on myeloid cells 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_067381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067381", "type": "external" } ], "gene_names_uniprotkb": "Trem1", "gene_names_refseq": "Trem1", "protein_names_uniprotkb": "Triggering receptor expressed on myeloid cells 1; TREM-1", "protein_names_refseq": "triggering receptor expressed in monocytes 1; triggering receptor expressed on myeloid cells 1 isoform 1 precursor", "tax_id": 10090, "disease": "bacterial sepsis (Disease Ontology:DOID:0040085); chorioamnionitis (Disease Ontology:DOID:0050697); malaria (Disease Ontology:DOID:12365); mesenteric vascular occlusion (Disease Ontology:DOID:13252); toxic shock syndrome (Disease Ontology:DOID:14115); depressive disorder (Disease Ontology:DOID:1596); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); acute pancreatitis (Disease Ontology:DOID:2913); pulmonary tuberculosis (Disease Ontology:DOID:2957); middle cerebral artery infarction (Disease Ontology:DOID:3525); pleural empyema (Disease Ontology:DOID:3798); bacterial gastritis (Disease Ontology:DOID:4033); melioidosis (Disease Ontology:DOID:5052); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); periodontitis (Disease Ontology:DOID:824); bacterial pneumonia (Disease Ontology:DOID:874); amyloidosis (Disease Ontology:DOID:9120); bacterial meningitis (Disease Ontology:DOID:9470)", "pathway": " (mmu:58217); (R-MMU-198933); (R-MMU-202733); (R-MMU-2172127)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10799849;15561137;17202378;23241959;27328755;37828378;38954781", "class_list": "", "function": "Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses. Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections (PubMed:23241959, PubMed:27328755). By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Crystal structure of the mouse TREM-1 extracellular domain at 1.76A resolution, [RefSeq, PubMed]; Regulation of TREM-1 and the soluble form of TREM-1 expression by prostaglandin E2 may modulate the inflammatory response to microbial pathogens, [RefSeq, PubMed]; Single-Cell RNA Sequencing Reveals Transcriptional Landscape of Neutrophils and Highlights the Role of TREM-1 in EAE., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAL7", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0097110 scaffold protein binding;GO:0140319 receptor decoy activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0070945 neutrophil-mediated killing of gram-negative bacterium;GO:0016477 cell migration;GO:0045087 innate immune response;GO:0002250 adaptive immune response;GO:0010666 positive regulation of cardiac muscle cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JKE2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKT4-1", "uniprot_id": [ { "id": "TR105_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKT4", "type": "external" } ], "mass": 34416.0, "length": 300, "protein_name": "Taste receptor type 2 member 105", "gene_name": "Tas2r105", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 105", "refseq_ac": [ { "id": "NP_065247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065247", "type": "external" } ], "gene_names_uniprotkb": "Tas2r105; Tas2r5; Tas2r9", "gene_names_refseq": "T2R05; T2R9; T2r5; Tas2r105; Tas2r5; mGR05; mt2r5", "protein_names_uniprotkb": "Taste receptor type 2 member 105; T2R105; T2R5; T2R9; Taste receptor type 2 member 5; Taste receptor type 2 member 9", "protein_names_refseq": "T2R105; candidate taste receptor T2R5; taste receptor T2R5; taste receptor type 2 member 105; taste receptor type 2 member 5; taste receptor type 2 member 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:57252); (R-MMU-418594); (R-MMU-420499); (R-MMU-9717207)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10761934;10761935;11696554;12139982;12581520;15759003;25681767;26071358;30243894;35820727", "class_list": "", "function": "Gustducin-coupled cycloheximide receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5., [UniProtKB, PubMed, PubMed]; Tas2Rs and taste-related signaling transduction cascades are also observed in mouse small intestine including duodenum, jejunum and ileum by RT-PCR and Western Blot, [RefSeq, PubMed]; The bitter taste receptors Tas2r105 and Tas2r106 are expressed in the renal corpuscle and the renal tubule, including the proximal tubule and distal tubule., [RefSeq, PubMed]; The mRNA expressions of the bitter taste receptor Tas2r105 and its coupled G protein gustducin were significantly decreased with aging. However, the majority of molecules tested did not show significant expression changes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste;GO:0050913 sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9JKT4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QUQ5-1", "uniprot_id": [ { "id": "TRPC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QUQ5", "type": "external" } ], "mass": 111575.0, "length": 974, "protein_name": "Short transient receptor potential channel 4", "gene_name": "Trpc4", "organism": "Mouse", "refseq_name": "short transient receptor potential channel 4 isoform 2", "refseq_ac": [ { "id": "NP_001240611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240611", "type": "external" } ], "gene_names_uniprotkb": "Trpc4; Trrp4", "gene_names_refseq": "CCE1; STRPC4; Trp4; Trpc4; Trrp4", "protein_names_uniprotkb": "Short transient receptor potential channel 4; Capacitative calcium entry channel Trp4; Receptor-activated cation channel TRP4; TrpC4", "protein_names_refseq": "capacitative calcium entry channel Trp4; putative capacitative calcium entry channel; receptor-activated cation channel TRP4; short transient receptor potential channel 4 isoform 2; short transient receptor potential channel 4; transient receptor protein 4", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); autism spectrum disorder (Disease Ontology:DOID:0060041); neurodegenerative disease (Disease Ontology:DOID:1289); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (mmu:22066); (R-MMU-3295583)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10980202;11175743;19070363;20458742;21750661;38636714;7575478;9512398", "class_list": "", "function": "Forms a receptor-activated non-selective calcium permeant cation channel (By similarity). Acts as a cell-cell contact-dependent endothelial calcium entry channel (By similarity). Forms a homomeric ion channel or a heteromeric ion channel with TRPC1; the heteromeric ion channel has reduced calcium permeability compared to the homomeric channel (By similarity). Also permeable to monovalent ions including sodium, lithium and cesium ions (By similarity)., [UniProtKB, UniProtKB]; TRPC4 aggravates hypoxic pulmonary hypertension by promoting pulmonary endothelial cell apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62350;Q9QUQ9;Q9QZC0", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005262 calcium channel activity;GO:0046872 metal ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006816 calcium ion transport;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0051924 regulation of calcium ion transport;GO:0070588 calcium ion transmembrane transport;GO:0014051 gamma-aminobutyric acid secretion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QUQ5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QX29-1", "uniprot_id": [ { "id": "TRPC5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QX29", "type": "external" } ], "mass": 111458.0, "length": 975, "protein_name": "Short transient receptor potential channel 5", "gene_name": "Trpc5", "organism": "Mouse", "refseq_name": "short transient receptor potential channel 5", "refseq_ac": [ { "id": "NP_033454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033454", "type": "external" } ], "gene_names_uniprotkb": "Trpc5; Trp5; Trrp5", "gene_names_refseq": "CCE2; TRP-5; TRP5; Trpc5; Trrp5", "protein_names_uniprotkb": "Short transient receptor potential channel 5; CCE2; Capacitative calcium entry channel 2; TRP-5; Transient receptor protein 5; Trp-related protein 5; TrpC5; mTRP5", "protein_names_refseq": "capacitative calcium entry channel 2; short transient receptor potential channel 5; transient receptor protein 5; trp-related protein 5; vtransient receptor potential cation channel, subfamily C, member 5", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); autism spectrum disorder (Disease Ontology:DOID:0060041); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:22067); (R-MMU-3295583)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10980202;15895247;20458742;32110987;35820727;38959890;39363236;8646775;9553080;9687496", "class_list": "", "function": "Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:9553080). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (PubMed:32110987). Acts on distinct neuronal populations in the hypothalamus to regulate innate behaviors including feeding, anxiety (flight/fight/fear), socialization and maternal care (PubMed:38959890)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Loss of transient receptor potential channel 5 causes obesity and postpartum depression., [RefSeq, PubMed]; Thermosensing ability of TRPC5: current knowledge and unsettled questions. Review article Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q61059;Q9QWT1;Q9R0D4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0003779 actin binding;GO:0005262 calcium channel activity;GO:0046872 metal ion binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0030426 growth cone;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0008284 positive regulation of cell population proliferation;GO:0010800 positive regulation of peptidyl-threonine phosphorylation;GO:0045666 positive regulation of neuron differentiation;GO:0051402 neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9QX29-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZC1-1", "uniprot_id": [ { "id": "TRPC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZC1", "type": "external" } ], "mass": 103620.0, "length": 910, "protein_name": "Short transient receptor potential channel 3", "gene_name": "Trpc3", "organism": "Mouse", "refseq_name": "short transient receptor potential channel 3 isoform 1", "refseq_ac": [ { "id": "NP_062383", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062383", "type": "external" } ], "gene_names_uniprotkb": "Trpc3; Trp3; Trrp3", "gene_names_refseq": "Mwk; Trcp3; Trp3; Trpc3; Trrp3", "protein_names_uniprotkb": "Short transient receptor potential channel 3; Receptor-activated cation channel TRP3; TRP-3; Transient receptor protein 3; Trp-related protein 3; TrpC3; mTrp3", "protein_names_refseq": "TRP-3; mTrp3; receptor-activated cation channel TRP3; short transient receptor potential channel 3 isoform 1; short transient receptor potential channel 3; transient receptor protein 3; trp-related protein 3", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); cerebellar ataxia type 41 (Disease Ontology:DOID:0111744); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:22065); (R-MMU-114508); (R-MMU-139853); (R-MMU-3295583)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "34203471;8646775;9512398", "class_list": "", "function": "Forms a receptor-activated non-selective calcium permeant cation channel. May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G protein coupled receptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1ATV3;Q61058", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005262 calcium channel activity;GO:0046872 metal ion binding;GO:0005227 calcium-activated cation channel activity;GO:0015279 store-operated calcium channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane", "go_biological_process": "GO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress;GO:0051592 response to calcium ion;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0007338 single fertilization;GO:0070588 calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QZC1-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0R1-1", "uniprot_id": [ { "id": "TRFM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0R1", "type": "external" } ], "mass": 81293.0, "length": 738, "protein_name": "Melanotransferrin", "gene_name": "Meltf", "organism": "Mouse", "refseq_name": "melanotransferrin precursor", "refseq_ac": [ { "id": "NP_038928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038928", "type": "external" } ], "gene_names_uniprotkb": "Meltf; Mfi2; Mtf", "gene_names_refseq": "CD228; MTf; Meltf; Mfi2", "protein_names_uniprotkb": "Melanotransferrin; MTf; Membrane-bound transferrin-like protein p97", "protein_names_refseq": "antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5; melanotransferrin precursor; membrane-bound transferrin-like protein p97", "tax_id": 10090, "disease": "chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419)", "pathway": " (mmu:30060); (R-MMU-163125); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10542324;11231300;12679380;15716025;16291590;16704991", "class_list": "", "function": "Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc., [UniProtKB]; Iron indices, tissue levels, hematology, and serum chemistry parameters demonstrated no differences between metallototransferrin deficient and wild-type mice, suggesting MTf was not essential for iron metabolism., [RefSeq, PubMed]; MTf represents the first identification of a plant lectin receptor involved in cell-shape changes and the differentiation of animal cells, [RefSeq, PubMed]; Melanotransferrin has a role in cell proliferation and tumorigenesis, [RefSeq, PubMed]; The distribution of MTf and its splice variants may provide clues to their possible biological roles in melanoma and other tumors., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0055037 recycling endosome", "go_biological_process": "GO:0010756 positive regulation of plasminogen activation;GO:1900025 negative regulation of substrate adhesion-dependent cell spreading;GO:0006826 iron ion transport;GO:0090091 positive regulation of extracellular matrix disassembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9R0R1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R244-1", "uniprot_id": [ { "id": "TRPC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R244", "type": "external" } ], "mass": 130531.0, "length": 1172, "protein_name": "Short transient receptor potential channel 2", "gene_name": "Trpc2", "organism": "Mouse", "refseq_name": "short transient receptor potential channel 2", "refseq_ac": [ { "id": "NP_001103367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103367", "type": "external" } ], "gene_names_uniprotkb": "Trpc2; Trp2; Trrp2", "gene_names_refseq": "3010009O07Rik; TRPC2a; TRPC2b; Trpc2; Trrp2; mTrp2; smTRPC2; trp2", "protein_names_uniprotkb": "Short transient receptor potential channel 2; TRP-2; Transient receptor protein 2; TrpC2; mTrp2", "protein_names_refseq": "short transient receptor potential channel 2; transient receptor potential 2-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:22064)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10051594;10318963;10998353;11823606;11972034;20596023;24089208", "class_list": "", "function": "Channel expressed specifically in sensory microvilli of the vomeronasal organ and likely to mediate pheromone sensory transduction., [RefSeq, PubMed]; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G protein-coupled receptors. May also be activated by intracellular calcium store depletion. Plays a role in mediating responsivity to pheromones that elicit aggressive and mating behaviors. Required for response to the Esp1 pheromone which enhances female sexual receptive behavior and to the Esp22 pheromone which inhibits adult male mating behavior., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ES59;Q9ES60;Q9R243", "ec_number_list": [], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005516 calmodulin binding;GO:0003684 damaged DNA binding;GO:0019992 diacylglycerol binding;GO:0015279 store-operated calcium channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005886 plasma membrane", "go_biological_process": "GO:0002121 inter-male aggressive behavior;GO:0002124 territorial aggressive behavior;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0006816 calcium ion transport;GO:0051480 regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9R244-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUH5-1", "uniprot_id": [ { "id": "TRI10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUH5", "type": "external" } ], "mass": 55630.0, "length": 489, "protein_name": "Tripartite motif-containing protein 10", "gene_name": "Trim10", "organism": "Mouse", "refseq_name": "tripartite motif-containing protein 10 isoform 2", "refseq_ac": [ { "id": "NP_035410", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035410", "type": "external" } ], "gene_names_uniprotkb": "Trim10; Herf1; Rnf9", "gene_names_refseq": "Herf1; Rnf9; Trim10", "protein_names_uniprotkb": "Tripartite motif-containing protein 10; Hematopoietic RING finger 1; RING finger protein 9", "protein_names_refseq": "hematopoietic RING finger 1; ring finger protein 9; tripartite motif protein 10; tripartite motif-containing protein 10 isoform 2; tripartite motif-containing protein 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:19824)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10207104;11331580;18560381;32343488;34428180;36972172", "class_list": "", "function": "E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells (PubMed:18560381). May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling (PubMed:32343488). In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity. Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Primary Spi-1/PU.1 downregulation acts on late erythroid differentiation through at least two pathways, one of which requires TRIM10/HERF1 upregulation and parallels the Spi-1/PU.1-induced Fli-1 shutoff regulatory cascade., [RefSeq, PubMed]; The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus., [RefSeq, PubMed]; Tripartite motif 10 regulates cardiac hypertrophy by targeting the PTEN/AKT pathway. Erratum:[J Cell Mol Med. 2023 Jul;27(13):1915-1917. doi: 10.1111/jcmm.17773. PMID: 37394903], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, 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Catalyzes preferentially the epoxidation of double bonds of PUFAs (PubMed:15084647). Converts arachidonic acid (ARA, C20:4(n-6)) primarily to stereospecific products 8R,9S-epoxyeicosatrienoate (EET) and 11R,12S-EET (PubMed:15084647). Plays a major role in the formation of EETs and hydroxy-EETs (HEETs) in kidney. Via EETs may inhibit the epithelial sodium channels (ENaCs) in nephron segments, preventing excessive sodium absorption during high dietary salt intake (PubMed:24368771, PubMed:24966089). Participates in the formation of anti-inflammatory hydroxyepoxyeicosatrienoic acids (HEETs) by converting 20-hydroxyeicosatetraenoic acid (20-HETE) to 20,8,9-HEET, an activator of PPARA (By similarity). Metabolizes eicosapentaenoic acid (EPA, C20:5(n-3)) to epoxyeicosatetraenoic acid (EETeTr) regioisomers, 8,9-, 11,12-, 14,15-, and 17,18- EETeTr, preferentially producing 17R,18S enantiomer (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:15084647)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Characterization of a role for the murine CYP2C44 epoxygenase and 14,15-EET in the ERK1/2-mediated regulation of amiloride-sensitive JNa+, [RefSeq, PubMed]; Cyp2c44 arachidonic acid epoxygenase is a component of the signaling pathways associated with VEGF-stimulated angiogenesis, [RefSeq, PubMed]; Cyp2c44 functions as an high potassium-inducible antihypertensive enzyme responsible for inhibiting ENaC activity and Na absorption in the aldosterone-sensitive distal nephron., [RefSeq, PubMed]; Epoxygenase Cyp2c44 Regulates Hepatic Lipid Metabolism and Insulin Signaling by Controlling FATP2 Localization and Activation of the DAG/PKCdelta Axis., [RefSeq, PubMed]; The anti-tumorigenic 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Promotes keratinocyte proliferation (PubMed:34351912). This contributes to the maintenance of skin homeostasis by enhancing wound healing after skin injury (PubMed:34351912). 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May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0043522 leucine zipper domain binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:1990090 cellular response to nerve growth factor stimulus;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1W2P7H4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A286YCQ8-1", "uniprot_id": [ { "id": "A0A286YCQ8_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A286YCQ8", "type": "external" } ], "mass": 9232.0, "length": 80, "protein_name": "Predicted gene, 47429", "gene_name": "Gm47429", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm47429", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene, 47429", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286YCQ8-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2ASU7-1", "uniprot_id": [ { "id": "A2ASU7_MOUSE", "url": "https://www.uniprot.org/uniprot/A2ASU7", "type": "external" } ], "mass": 37193.0, "length": 327, "protein_name": "Olfactory receptor", "gene_name": "Or5m12", "organism": "Mouse", "refseq_name": "olfactory receptor 1024", "refseq_ac": [ { "id": "NP_001005230", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005230", "type": "external" } ], "gene_names_uniprotkb": "Or5m12; Olfr1024", "gene_names_refseq": "MOR197-1; Olfr1024; Or5m12", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-47384320-47383337; olfactory receptor 1024; olfactory receptor MOR197-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:257900)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2ASU7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PXM9-1", "uniprot_id": [ { "id": "E9PXM9_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PXM9", "type": "external" } ], "mass": 53411.0, "length": 466, "protein_name": "F-box and WD-40 domain protein 24", "gene_name": "Fbxw24", "organism": "Mouse", "refseq_name": "F-box and WD-40 domain protein 24", "refseq_ac": [ { "id": "NP_001013798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013798", "type": "external" } ], "gene_names_uniprotkb": "Fbxw24", "gene_names_refseq": "EG382106; Fbxw24; Gm5162", "protein_names_uniprotkb": "F-box and WD-40 domain protein 24", "protein_names_refseq": "F-box and WD-40 domain protein 24", "tax_id": 10090, "disease": "", "pathway": " (mmu:382106)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PXM9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q9B7-1", "uniprot_id": [ { "id": "E9Q9B7_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q9B7", "type": "external" } ], "mass": 199184.0, "length": 1793, "protein_name": "Kinase D-interacting substrate of 220 kDa", "gene_name": "Kidins220", "organism": "Mouse", "refseq_name": "kinase D-interacting substrate of 220 kDa isoform 5", "refseq_ac": [ { "id": "NP_001074847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074847", "type": "external" } ], "gene_names_uniprotkb": "Kidins220", "gene_names_refseq": "3110039L19Rik; C330002I19Rik; Kidins220; mKIAA1250", "protein_names_uniprotkb": "Kinase D-interacting substrate of 220 kDa; Ankyrin repeat-rich membrane-spanning protein", "protein_names_refseq": "kinase D-interacting substrate of 220 kDa isoform 5; kinase D-interacting substrate of 220 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:77480); (R-MMU-170984); (R-MMU-9696270); (R-MMU-9696273)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;17322886;18250455;19144319;19449316;19903810;21750661;25428506;26495903;28011936;28315936;30779550;34279618;35916735;37542079;38489359", "class_list": "", "function": "A developmental stage- and Kidins220-dependent switch in astrocyte responsiveness to brain-derived neurotrophic factor., [RefSeq, PubMed]; ARMS/Kidins220 regulates nociception by controlling brain-derived neurotrophic factor secretion., [RefSeq, PubMed]; Kidins220 and Aiolos promote thymic iNKT cell development by reducing TCR signals., [RefSeq, PubMed]; Kidins220 sets the threshold for survival of neural stem cells and progenitors to sustain adult neurogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Kidins220/ARMS is a key modulator of the activity of microtubule-regulating proteins known to actively regulate neuronal morphogenesis and suggest a mechanism by which it contributes to control neuronal development., [RefSeq, PubMed]; This study suggested that ARMS/Kidins220 is important for the growth of dendritic arbors and spine stability during an activity- and BDNF-dependent period of development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030165 PDZ domain binding;GO:0019887 protein kinase regulator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0005770 late endosome;GO:0098978 glutamatergic synapse;GO:0045202 synapse", "go_biological_process": "GO:0007399 nervous system development;GO:0001701 in utero embryonic development;GO:0010976 positive regulation of neuron projection development;GO:1990090 cellular response to nerve growth factor stimulus;GO:0048813 dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "E9Q9B7-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q9M9-1", "uniprot_id": [ { "id": "E9Q9M9_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q9M9", "type": "external" } ], "mass": 66606.0, "length": 605, "protein_name": "Kelch domain containing 7B", "gene_name": "Klhdc7b", "organism": "Mouse", "refseq_name": "kelch domain-containing protein 7B", "refseq_ac": [ { "id": "NP_001153650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153650", "type": "external" } ], "gene_names_uniprotkb": "Klhdc7b", "gene_names_refseq": "EG546648; Gm306; Klhdc7b", "protein_names_uniprotkb": "Kelch domain containing 7B", "protein_names_refseq": "kelch domain-containing protein 7B", "tax_id": 10090, "disease": "", "pathway": " (mmu:546648)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q9M9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A087WS16-1", "uniprot_id": [ { "id": "A0A087WS16_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A087WS16", "type": "external" } ], "mass": 288693.0, "length": 2677, "protein_name": "Collagen, type VI, alpha 3", "gene_name": "Col6a3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Col6a3", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagen, type VI, alpha 3", "protein_names_refseq": "", "tax_id": 10090, "disease": "congenital muscular dystrophy (Disease Ontology:DOID:0050557); Ullrich congenital muscular dystrophy (Disease Ontology:DOID:0050558); Ullrich congenital muscular dystrophy 1C (Disease Ontology:DOID:0060943); Bethlem myopathy 1C (Disease Ontology:DOID:0061200); dystonia 27 (Disease Ontology:DOID:0090050); stomach cancer (Disease Ontology:DOID:10534); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); uterine fibroid (Disease Ontology:DOID:13223); thoracic aortic aneurysm (Disease Ontology:DOID:14004); communication disorder (Disease Ontology:DOID:2033); colon cancer (Disease Ontology:DOID:219); myocardial infarction (Disease Ontology:DOID:5844); chronic kidney disease (Disease Ontology:DOID:784); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (R-MMU-1442490); (R-MMU-1650814); (R-MMU-186797); (R-MMU-2022090); (R-MMU-216083); (R-MMU-3000178); (R-MMU-419037); (R-MMU-8948216)", "pathway_count": 8, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;24332716;37507081;39927985", "class_list": "", "function": "Collagen VI acts as a cell-binding protein., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 19, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005589 collagen type VI trimer;GO:0001527 microfibril;GO:0005615 extracellular space;GO:0042383 sarcolemma", "go_biological_process": "GO:0007155 cell adhesion;GO:0051402 neuron apoptotic process;GO:0009411 response to UV;GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "A0A087WS16-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4J1P8-1", "uniprot_id": [ { "id": "A0A0B4J1P8_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0B4J1P8", "type": "external" } ], "mass": 12517.0, "length": 112, "protein_name": "T cell receptor beta, variable 13-1", "gene_name": "Trbv13-1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trbv13-1", "gene_names_refseq": "", "protein_names_uniprotkb": "T cell receptor beta, variable 13-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0B4J1P8-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PVZ8-1", "uniprot_id": [ { "id": "E9PVZ8_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PVZ8", "type": "external" } ], "mass": 370154.0, "length": 3238, "protein_name": "Golgin B1", "gene_name": "Golgb1", "organism": "Mouse", "refseq_name": "golgin subfamily B member 1", "refseq_ac": [ { "id": "NP_084311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084311", "type": "external" } ], "gene_names_uniprotkb": "Golgb1", "gene_names_refseq": "4930428L02Rik; 628101; 6330407A06Rik; C130074L01Rik; F730017E11Rik; Gm6840; Golgb1; mKIAA4151", "protein_names_uniprotkb": "Golgin B1", "protein_names_refseq": "giantin; golgi autoantigen, golgin subfamily b, macrogolgin 1; golgin subfamily B member 1", "tax_id": 10090, "disease": "hyperphosphatemic familial tumoral calcinosis (Disease Ontology:DOID:0111063); osteochondrodysplasia (Disease Ontology:DOID:2256); cleft palate (Disease Ontology:DOID:674)", "pathway": " (mmu:224139); (R-MMU-432722); (R-MMU-6807878)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19144319;21750661;25605945;26495903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005801 cis-Golgi network;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0035988 chondrocyte proliferation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "E9PVZ8-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q8T2-1", "uniprot_id": [ { "id": "PRD15_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q8T2", "type": "external" } ], "mass": 132870.0, "length": 1174, "protein_name": "PR domain zinc finger protein 15", "gene_name": "Prdm15", "organism": "Mouse", "refseq_name": "PR domain zinc finger protein 15 isoform 2", "refseq_ac": [ { "id": "NP_001346006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001346006", "type": "external" } ], "gene_names_uniprotkb": "Prdm15", "gene_names_refseq": "C21orf83; E130018M06Rik; ORF62; Prdm15; Zfp298", "protein_names_uniprotkb": "PR domain zinc finger protein 15; 2.1.1.-; PR domain-containing protein 15", "protein_names_refseq": "PR domain zinc finger protein 15 isoform 2; PR domain zinc finger protein 15; PR domain-containing protein 15; zinc finger protein 298", "tax_id": 10090, "disease": "", "pathway": " (mmu:114604)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;28740264;31950080;34428180", "class_list": "", "function": "Findings indicate that PR domain containing 15 protein (PRDM15) is important in both mouse and human induced pluripotent stem cells (iPSCs) reprogramming., [RefSeq, PubMed]; PRDM15 loss of function links NOTCH and WNT/PCP signaling to patterning defects in holoprosencephaly. Publication Status: Online-Only, [RefSeq, PubMed]; Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Also plays a role in induced pluripotent stem cells (iPSCs) reprogramming. Involved in early embryo development., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9Q6A1;Q3UML7", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0008168 methyltransferase activity;GO:1990841 promoter-specific chromatin binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0010468 regulation of gene expression;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E9Q8T2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "K7N6K2-1", "uniprot_id": [ { "id": "TR34B_MOUSE", "url": "https://www.uniprot.org/uniprot/K7N6K2", "type": "external" } ], "mass": 55858.0, "length": 485, "protein_name": "E3 ubiquitin-protein ligase TRIM34B", "gene_name": "Trim34b", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase TRIM34B", "refseq_ac": [ { "id": "NP_001230845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230845", "type": "external" } ], "gene_names_uniprotkb": "Trim34b", "gene_names_refseq": "Gm15134; Trim34-2; Trim34b", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM34B; 2.3.2.27; Tripartite motif-containing protein 34B", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM34B; tripartite motif-containing protein 34B", "tax_id": 10090, "disease": "", "pathway": " (mmu:434218)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32094504", "class_list": "", "function": "Functions as antiviral protein and contributes to the defense against retroviral infections (By similarity). Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses. During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination. In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis (By similarity). Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis. Also promotes the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells (By similarity). Regulates intestinal inflammation by controlling the exocytosis of the major component of colonic mucus MUC2 from colonic goblet cells (PubMed:32094504)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0016567 protein ubiquitination;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "K7N6K2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YUE4-1", "uniprot_id": [ { "id": "F151B_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YUE4", "type": "external" } ], "mass": 31409.0, "length": 279, "protein_name": "Protein FAM151B", "gene_name": "Fam151b", "organism": "Mouse", "refseq_name": "protein FAM151B", "refseq_ac": [ { "id": "NP_001157099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157099", "type": "external" } ], "gene_names_uniprotkb": "Fam151b", "gene_names_refseq": "4930405M20Rik; Fam151b", "protein_names_uniprotkb": "Protein FAM151B", "protein_names_refseq": "protein FAM151B", "tax_id": 10090, "disease": "", "pathway": " (mmu:73942)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31949211", "class_list": "", "function": "Essential for survival of retinal photoreceptor cells., [UniProtKB, PubMed]; Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0042461 photoreceptor cell development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3YUE4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F8VQ18-1", "uniprot_id": [ { "id": "F8VQ18_MOUSE", "url": "https://www.uniprot.org/uniprot/F8VQ18", "type": "external" } ], "mass": 39523.0, "length": 346, "protein_name": "Olfactory receptor", "gene_name": "Or51t4", "organism": "Mouse", "refseq_name": "olfactory receptor 574", "refseq_ac": [ { "id": "NP_666472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666472", "type": "external" } ], "gene_names_uniprotkb": "Or51t4; Olfr574", "gene_names_refseq": "MOR14-9; Olfr574; Or51t4", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 574; olfactory receptor MOR14-9", "tax_id": 10090, "disease": "", "pathway": " (mmu:258357)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Fam124a", "protein_names_uniprotkb": "Family with sequence similarity 124, member A", "protein_names_refseq": "protein FAM124A", "tax_id": 10090, "disease": "", "pathway": " (mmu:629059)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3Z5V4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9QAQ8-1", "uniprot_id": [ { "id": "E9QAQ8_MOUSE", "url": "https://www.uniprot.org/uniprot/E9QAQ8", "type": "external" } ], "mass": 372170.0, "length": 3455, "protein_name": "Mucin-2", "gene_name": "Muc5ac", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Muc5ac", "gene_names_refseq": "", "protein_names_uniprotkb": "Mucin-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); dry eye syndrome (Disease Ontology:DOID:10140); otitis media (Disease Ontology:DOID:10754); gastric ulcer (Disease Ontology:DOID:10808); Sjogren's syndrome (Disease Ontology:DOID:12894); angle-closure glaucoma (Disease Ontology:DOID:13550); cystic fibrosis (Disease Ontology:DOID:1485); cystitis (Disease Ontology:DOID:1679); glaucoma (Disease Ontology:DOID:1686); pancreatic cancer (Disease Ontology:DOID:1793); asthma (Disease Ontology:DOID:2841); mucinous adenocarcinoma (Disease Ontology:DOID:3030); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); pulmonary fibrosis (Disease Ontology:DOID:3770); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); common bile duct neoplasm (Disease Ontology:DOID:4608); cholangiocarcinoma (Disease Ontology:DOID:4947); stomach disease (Disease Ontology:DOID:76); corneal ulcer (Disease Ontology:DOID:8463); keratoconjunctivitis (Disease Ontology:DOID:9368)", "pathway": " (mmu:17833); (R-MMU-913709); (R-MMU-977068)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "", "predicted_glycosites": 9, "predicted_n_glycosites": 0, "predicted_o_glycosites": 9, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 5, "disease_count": 22, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0070701 mucus layer;GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0036438 maintenance of lens transparency", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "E9QAQ8-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F8VPZ3-1", "uniprot_id": [ { "id": "UBP32_MOUSE", "url": "https://www.uniprot.org/uniprot/F8VPZ3", "type": "external" } ], "mass": 181733.0, "length": 1604, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 32", "gene_name": "Usp32", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 32", "refseq_ac": [ { "id": "NP_001025105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025105", "type": "external" } ], "gene_names_uniprotkb": "Usp32", "gene_names_refseq": "2900074J03Rik; 6430526O11Rik; Usp32", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 32; 3.4.19.12; Deubiquitinating enzyme 32; Ubiquitin thioesterase 32; Ubiquitin-specific-processing protease 32", "protein_names_refseq": "deubiquitinating enzyme 32; ubiquitin carboxyl-terminal hydrolase 32; ubiquitin specific protease 32; ubiquitin thioesterase 32; ubiquitin-specific-processing protease 32", "tax_id": 10090, "disease": "", "pathway": " (mmu:237898)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25605945", "class_list": "", "function": "Deubiquitinase that can remove conjugated ubiquitin from target proteins, such as RAB7A and LAMTOR1 (By similarity). Acts as a positive regulator of the mTORC1 signaling by mediating deubiquitination of LAMTOR1, thereby promoting the association between LAMTOR1 and the lysosomal V-ATPase complex and subsequent activation of the mTORC1 complex (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3US74;Q6PD17;Q7TT84;Q8CCP4", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006508 proteolysis;GO:0016579 protein deubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "F8VPZ3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3QPC3-1", "uniprot_id": [ { "id": "ACTMP_MOUSE", "url": "https://www.uniprot.org/uniprot/J3QPC3", "type": "external" } ], "mass": 38901.0, "length": 361, "protein_name": "Actin maturation protease", "gene_name": "Actmap", "organism": "Mouse", "refseq_name": "actin maturation protease isoform 3", "refseq_ac": [ { "id": "NP_001277442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277442", "type": "external" } ], "gene_names_uniprotkb": "Actmap; BC024978", "gene_names_refseq": "Actmap", "protein_names_uniprotkb": "Actin maturation protease; 3.4.11.-; Actin aminopeptidase ACTMAP", "protein_names_refseq": "UPF0692 protein C19orf54 homolog; actin aminopeptidase ACTMAP; actin maturation protease isoform 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:414069)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;36173861", "class_list": "", "function": "Actin maturation protease that specifically mediates the cleavage of immature acetylated N-terminal actin, thereby contributing to actin maturation (PubMed:36173861). Cleaves N-terminal acetylated methionine of immature cytoplasmic beta- and gamma-actins Actb and Actg1 after translation (PubMed:36173861). Cleaves N-terminal acetylated cysteine of muscle alpha-actins Acta1, Actc1 and Acta2 after canonical removal of N-terminal methionine (PubMed:36173861)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3Z7G4", "ec_number_list": [ { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" } ], "go_molecular_function": "GO:0070005 cysteine-type aminopeptidase activity;GO:0004239 initiator methionyl aminopeptidase activity;GO:0004177 aminopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0016485 protein processing;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "J3QPC3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "L7N2A2-1", "uniprot_id": [ { "id": "L7N2A2_MOUSE", "url": "https://www.uniprot.org/uniprot/L7N2A2", "type": "external" } ], "mass": 23674.0, "length": 199, "protein_name": "Spermatogenesis associated glutamate (E)-rich protein 1J", "gene_name": "Speer1j", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Speer1j; Gm8906", "gene_names_refseq": "", "protein_names_uniprotkb": "Spermatogenesis associated glutamate (E)-rich protein 1J", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "L7N2A2-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A654-1", "uniprot_id": [ { "id": "A2A654_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A654", "type": "external" } ], "mass": 333228.0, "length": 3036, "protein_name": "Bromodomain PHD finger transcription factor", "gene_name": "Bptf", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Bptf", "gene_names_refseq": "", "protein_names_uniprotkb": "Bromodomain PHD finger transcription factor", "protein_names_refseq": "", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); neurodevelopmental disorder with dysmorphic facies and distal limb anomalies (Disease Ontology:DOID:0070514); Alzheimer's disease (Disease Ontology:DOID:10652); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); Kaposi's sarcoma (Disease Ontology:DOID:8632)", "pathway": "", "pathway_count": 0, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21606357;21750661;22645316;24129315;25605945;34678516;40997131", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 15, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 15, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 15, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 5, "glyco_site_count": 21, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0043565 sequence-specific DNA binding;GO:0008094 ATP-dependent activity, acting on DNA;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0030425 dendrite;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "A2A654-1", "record_type": "protein", 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"url": "https://www.uniprot.org/uniprot/E9Q1Z2", "type": "external" } ], "mass": 68431.0, "length": 618, "protein_name": "ENTH domain containing 1", "gene_name": "Enthd1", "organism": "Mouse", "refseq_name": "ENTH domain-containing protein 1", "refseq_ac": [ { "id": "NP_001156661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156661", "type": "external" } ], "gene_names_uniprotkb": "Enthd1", "gene_names_refseq": "Enthd1; Gm1242; Gm86", "protein_names_uniprotkb": "ENTH domain containing 1", "protein_names_refseq": "ENTH domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:383075)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, 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protein LOC625464", "tax_id": 10090, "disease": "", "pathway": " (mmu:625464)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q3K0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q9W4-1", "uniprot_id": [ { "id": "S27A6_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q9W4", "type": "external" } ], "mass": 70192.0, "length": 619, "protein_name": "Long-chain fatty acid transport protein 6", "gene_name": "Slc27a6", "organism": "Mouse", "refseq_name": "long-chain fatty acid transport protein 6", "refseq_ac": [ { "id": "NP_001074541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074541", "type": "external" } ], "gene_names_uniprotkb": "Slc27a6; Acsvl2; Facvl2; Fatp1", "gene_names_refseq": "4732438L20Rik; FACVL2; FATP-6; FATP6; Slc27a6; VLACS2; VLCS-H1; VLCSH1; mVLCS-H1", "protein_names_uniprotkb": "Long-chain fatty acid transport protein 6; 6.2.1.-; 6.2.1.15; 6.2.1.3; Arachidonate--CoA ligase; FATP-6; Fatty acid transport protein 6; Fatty-acid-coenzyme A ligase, very long-chain 2; Long-chain-fatty-acid--CoA ligase; Solute carrier family 27 member 6; VLACS2; VLCSH1; Very long-chain acyl-CoA synthetase homolog 1; mVLCS-H1", "protein_names_refseq": "arachidonate--CoA ligase; fatty acid transport protein 6; fatty-acid-coenzyme A ligase, very long-chain 2; long-chain fatty acid transport protein 6; long-chain-fatty-acid--CoA ligase; solute carrier family 27 member 6; very long-chain acyl-CoA synthetase homolog 1", "tax_id": 10090, "disease": "myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:225579); (R-MMU-804914)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15699031;25428506;34428180", "class_list": "", "function": "Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (By similarity). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates (PubMed:15699031). Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation such as the heart (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.76", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0000166 nucleotide binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0031957 very long-chain fatty acid-CoA ligase activity;GO:0047676 arachidonate-CoA ligase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0001676 long-chain fatty acid metabolic process;GO:0044539 long-chain fatty acid import into cell", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9Q9W4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3KML0-1", "uniprot_id": [ { "id": "J3KML0_MOUSE", "url": "https://www.uniprot.org/uniprot/J3KML0", "type": "external" } ], "mass": 31346.0, "length": 287, "protein_name": "Doublecortin domain containing 2b", "gene_name": "Dcdc2b", "organism": "Mouse", "refseq_name": "doublecortin domain-containing protein 2B", "refseq_ac": [ { "id": "NP_001182659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182659", "type": "external" } ], "gene_names_uniprotkb": "Dcdc2b", "gene_names_refseq": "Dcdc2b; Gm12964; Gm1366", "protein_names_uniprotkb": "Doublecortin domain containing 2b", "protein_names_refseq": "doublecortin domain-containing protein 2B", "tax_id": 10090, "disease": "", "pathway": " (mmu:100504491)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. 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they represents a new family of DNA binding proteins that may be components of transciptional pathways that regulate a number of developmental and physiologic processes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E9Q5N9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3QK56-1", "uniprot_id": [ { "id": "J3QK56_MOUSE", "url": "https://www.uniprot.org/uniprot/J3QK56", "type": "external" } ], "mass": 22427.0, "length": 214, "protein_name": "RIKEN cDNA 4930544D05 gene", "gene_name": "4930544D05Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein C17orf107 homolog isoform X1", "refseq_ac": [ { "id": "XP_006534029", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006534029", "type": "external" } ], "gene_names_uniprotkb": "4930544D05Rik", "gene_names_refseq": "4930544D05Rik", "protein_names_uniprotkb": "RIKEN cDNA 4930544D05 gene", "protein_names_refseq": "uncharacterized protein C17orf107 homolog isoform X1", "tax_id": 10090, "disease": "", "pathway": " (mmu:668433)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, 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"glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "J3QK56-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q7P2-1", "uniprot_id": [ { "id": "E9Q7P2_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q7P2", "type": "external" } ], "mass": 242894.0, "length": 2199, "protein_name": "Voltage-dependent T-type calcium channel subunit alpha", "gene_name": "Cacna1i", "organism": "Mouse", "refseq_name": "voltage-dependent T-type calcium channel subunit alpha-1I", "refseq_ac": [ { "id": "NP_001037773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037773", "type": "external" } ], "gene_names_uniprotkb": "Cacna1i", "gene_names_refseq": "Ca(V)3.3; Cacna1i", "protein_names_uniprotkb": "Voltage-dependent T-type calcium channel subunit alpha", "protein_names_refseq": "low voltage-activated T-type calcium channel alpha-1 subunit (CACNA1I); low-voltage-activated calcium channel alpha13.3; voltage-dependent T-type calcium channel subunit alpha-1I", "tax_id": 10090, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:239556)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;12614673;21750661", "class_list": "", "function": "Expression of T-type calcium channels increases during perinatal development in various brain regions and in the spinal cord. Erratum:[Neuroscience. 2006 Oct 13;142(2):607], [RefSeq, PubMed]; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the `low-voltage activated (LVA)` group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, 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"glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PWJ7-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q4X2-1", "uniprot_id": [ { "id": "E9Q4X2_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q4X2", "type": "external" } ], "mass": 172766.0, "length": 1504, "protein_name": "UDP-glucose:glycoprotein glucosyltransferase 1", "gene_name": "Uggt2", "organism": "Mouse", "refseq_name": "UDP-glucose:glycoprotein glucosyltransferase 2 precursor", "refseq_ac": [ { "id": "NP_001074721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074721", "type": "external" } ], "gene_names_uniprotkb": "Uggt2", "gene_names_refseq": "1810064L21Rik; 3110001A05Rik; 3110027P15Rik; A230065J02Rik; Ugcgl2; Uggt2", "protein_names_uniprotkb": "UDP-glucose:glycoprotein glucosyltransferase 1; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose ceramide glucosyltransferase-like 1", "protein_names_refseq": "UDP-glucose ceramide glucosyltransferase-like 2; UDP-glucose:glycoprotein glucosyltransferase 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:66435)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;24140206;36508673", "class_list": "glycogene;glycosyltransferase", "function": "Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation., [UniProtKB, UniProtKB, UniProtKB]; Selective involvement of UGGT variant: UGGT2 in protecting mouse embryonic fibroblasts from saturated lipid-induced ER stress., [RefSeq, PubMed]; The expression of two UGGT isoforms, UGGT1 and UGGT2 was demonstrated and both isoforms are active mouse hybridoma cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, 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Radial spoke complexes are important for ciliary motility (PubMed:34871179)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0097729 9+2 motile cilium;GO:0042995 cell projection", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E9PYQ0-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AEN9-1", "uniprot_id": [ { "id": "A2AEN9_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AEN9", "type": "external" } ], "mass": 18508.0, "length": 163, "protein_name": "Predicted gene 5938", "gene_name": "Gm5938", "organism": "Mouse", "refseq_name": "odorant binding protein IA-like precursor", "refseq_ac": [ { "id": "NP_001079003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001079003", "type": "external" } ], "gene_names_uniprotkb": "Gm5938", "gene_names_refseq": "EG546335; Gm5938; OBP6", "protein_names_uniprotkb": "Predicted gene 5938", "protein_names_refseq": "odorant binding protein 6; odorant binding protein IA-like precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:546335)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036094 small molecule binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2AEN9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YXF5-1", "uniprot_id": [ { "id": "CO7_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YXF5", "type": "external" } ], "mass": 93337.0, "length": 845, "protein_name": "Complement component C7", "gene_name": "C7", "organism": "Mouse", "refseq_name": "complement component C7 precursor", "refseq_ac": [ { "id": "NP_001230766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230766", "type": "external" } ], "gene_names_uniprotkb": "C7", "gene_names_refseq": "A530026G17; C7; Gm1238", "protein_names_uniprotkb": "Complement component C7", "protein_names_refseq": "complement component C7 precursor; complement component C7", "tax_id": 10090, "disease": "complement component 7 deficiency (Disease Ontology:DOID:0060300)", "pathway": " (mmu:109828); (R-MMU-166665); (R-MMU-977606)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C7 serves as a membrane anchor. During MAC assembly, associates with C5b and C6 to form the C5b-7 complex, a key lipophilic precursor of the MAC complex, which associates with the outer leaflet and reduces the energy for membrane bending., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005579 membrane attack complex;GO:0044218 other organism cell membrane", "go_biological_process": "GO:0031640 killing of cells of another organism;GO:0050778 positive regulation of immune response;GO:0006958 complement activation, classical pathway;GO:0006956 complement activation;GO:0160257 complement activation, GZMK pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3YXF5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z236-1", "uniprot_id": [ { "id": "D3Z236_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z236", "type": "external" } ], "mass": 21587.0, "length": 184, "protein_name": "Predicted gene 3676", "gene_name": "Gm3676", "organism": "Mouse", "refseq_name": "predicted gene 3676", "refseq_ac": [ { "id": "NP_001423226", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001423226", "type": "external" } ], "gene_names_uniprotkb": "Gm3676", "gene_names_refseq": "100042114; Gm3676", "protein_names_uniprotkb": "Predicted gene 3676", "protein_names_refseq": "predicted gene 3676", "tax_id": 10090, "disease": "", "pathway": " (mmu:100042114)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z236-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z2H9-1", "uniprot_id": [ { "id": "D3Z2H9_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z2H9", "type": "external" } ], "mass": 28992.0, "length": 248, "protein_name": "Tropomyosin 3, related sequence 7", "gene_name": "Tpm3-rs7", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tpm3-rs7", "gene_names_refseq": "", "protein_names_uniprotkb": "Tropomyosin 3, related sequence 7", "protein_names_refseq": "", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005884 actin filament;GO:0005903 brush border", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z2H9-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z6W3-1", "uniprot_id": [ { "id": "D3Z6W3_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z6W3", "type": "external" } ], "mass": 34700.0, "length": 317, "protein_name": "Retinol dehydrogenase", "gene_name": "Rdh8", "organism": "Mouse", "refseq_name": "retinol dehydrogenase 8", "refseq_ac": [ { "id": "NP_001025461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025461", "type": "external" } ], "gene_names_uniprotkb": "Rdh8", "gene_names_refseq": "Gm182; Rdh8; prRDH", "protein_names_uniprotkb": "Retinol dehydrogenase; 1.1.1.300", "protein_names_refseq": "retinol dehydrogenase 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:235033)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15755727;18658157;21750661", "class_list": "", "function": "Mice lacking both the ATP-binding cassette transporter 4 (Abca4) and enzyme retinol dehydrogenase 8 (Rdh8), proteins critical for all-trans-retinal clearance from photoreceptors, developed severe RPE/photoreceptor dystrophy at an early age, [RefSeq, PubMed]; PrRDH is an enzyme that catalyzes reduction of all-trans-retinal in the rod outer segment, most noticeably at higher light intensities and prolonged illumination, but is not an essential enzyme of the retinoid cycle, [RefSeq, PubMed]; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "1.1.1.330", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.330", "type": "external" }, { "id": "1.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.21", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" }, { "id": "1.1.1.n12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12", "type": "external" }, { "id": "1.1.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.51", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" } ], "go_molecular_function": "GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0042572 retinol metabolic process;GO:0007601 visual perception;GO:0006703 estrogen biosynthetic process;GO:0061370 testosterone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3Z6W3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q658-1", "uniprot_id": [ { "id": "E9Q658_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q658", "type": "external" } ], "mass": 14093.0, "length": 125, "protein_name": "Prostate and testis expressed 1", "gene_name": "Pate1", "organism": "Mouse", "refseq_name": "prostate and testis expressed protein 1 precursor", "refseq_ac": [ { "id": "NP_001186882", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186882", "type": "external" } ], "gene_names_uniprotkb": "Pate1; Gm17252", "gene_names_refseq": "Gm17252; Pate1; Pate", "protein_names_uniprotkb": "Prostate and testis expressed 1", "protein_names_refseq": "prostate and testis expressed protein 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:100312987)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;21942998", "class_list": "", "function": "Characterization of a gene cluster consisting of at least 14 expressed Pate gene members, including Acrv1, Sslp1 and a previously uncharacterized gene which we named Pate-X. 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"disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "E0CYV9-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q876-1", "uniprot_id": [ { "id": "ABCAC_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q876", "type": "external" } ], "mass": 292592.0, "length": 2595, "protein_name": "Glucosylceramide transporter ABCA12", "gene_name": "Abca12", "organism": "Mouse", "refseq_name": "glucosylceramide transporter ABCA12", "refseq_ac": [ { "id": "NP_780419", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780419", "type": "external" } ], "gene_names_uniprotkb": "Abca12", "gene_names_refseq": "4832428G11Rik; 4833417A11Rik; Abca12", "protein_names_uniprotkb": "Glucosylceramide transporter ABCA12; 7.6.2.1; ATP-binding cassette sub-family A member 12", "protein_names_refseq": "ATP-binding cassette, sub-family A (ABC1), member 12; glucosylceramide transporter ABCA12", "tax_id": 10090, "disease": "autosomal recessive congenital ichthyosis 1 (Disease Ontology:DOID:0060656); autosomal recessive congenital ichthyosis 4A (Disease Ontology:DOID:0060712); autosomal recessive congenital ichthyosis 4B (Disease Ontology:DOID:0060713)", "pathway": " (mmu:74591); (R-MMU-1369062)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "18632686;18802465;18957418;20489143;23931754;24293640;27551807;32072744;32873425", "class_list": "", "function": "ABCA12 activity is required for the generation of long-chain ceramide esters that are essential for the development of normal skin structure and function, [RefSeq, PubMed]; ABCA12 plays pivotal roles in lung and skin barrier functions in Harlequin ichthyosis disease midel., [RefSeq, PubMed]; ABCA12 regulates insulin secretion from beta-cells., [RefSeq, PubMed]; Abca12 is a regulator of lipid transport and homeostasis. Erratum:[PLoS Genet. 2008 Oct;4(10). doi: 10.1371/annotation/02a793a0-160f-46b9-abaa-4a3d3eecdde2. Slattery, Keith [corrected to Satterley, Keith]] Publication Status: Online-Only, [RefSeq, PubMed]; Acute skin barrier disruption alters the secretion of lamellar bodies via the multilayered expression of ABCA12., [RefSeq, PubMed]; Results indicate that disrupted keratinocyte differentiation during the fetal development is involved in the pathomechanism of HI and, during maturation, Abca12(-/-) epidermal keratinocytes regain normal differentiation processes., [RefSeq, PubMed]; Transports lipids such as glucosylceramides from the outer to the inner leaflet of lamellar granules (LGs) membrane, whereby the lipids are finally transported to the keratinocyte periphery via the trans-Golgi network and LGs and released to the apical surface of the granular keratinocytes to form lipid lamellae in the stratum corneum of the epidermis, which is essential for skin barrier function (PubMed:18802465, PubMed:18957418, PubMed:20489143, PubMed:24293640, PubMed:27551807). In the meantime, participates in the transport of the lamellar granules-associated proteolytic enzymes, in turn regulates desquamation and keratinocyte differentiation (PubMed:20489143, PubMed:27551807). Furthermore, is essential for the regulation of cellular cholesterol homeostasis by regulating ABCA1-dependent cholesterol efflux from macrophages through interaction with NR1H2 and ABCA1 (PubMed:18802465, PubMed:23931754). Plays pleiotropic roles in regulating glucose stimulated insulin secretion from beta cells, regulating the morphology and fusion of insulin granules, lipid raft abundance and the actin cytoskeleton (PubMed:32072744). Also involved in lung surfactant biogenesis (PubMed:18632686)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 40, "predicted_n_glycosites": 39, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 40, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005319 lipid transporter activity;GO:0005524 ATP binding;GO:0034191 apolipoprotein A-I receptor binding;GO:0042626 ATPase-coupled transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0006886 intracellular protein transport;GO:0010875 positive regulation of cholesterol efflux;GO:0031424 keratinization;GO:0032940 secretion by cell", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "E9Q876-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3QMI4-1", "uniprot_id": [ { "id": "CAHM3_MOUSE", "url": "https://www.uniprot.org/uniprot/J3QMI4", "type": "external" } ], "mass": 39328.0, "length": 347, "protein_name": "Calcium homeostasis modulator protein 3", "gene_name": "Calhm3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Calhm3", "gene_names_refseq": "", "protein_names_uniprotkb": "Calcium homeostasis modulator protein 3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "29681531;30804437;33788965", "class_list": "", "function": "Pore-forming subunit of gustatory voltage-gated ion channels required for sensory perception of sweet, bitter and umami tastes. With CALHM1 forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to membrane depolarization and low extracellular Ca(2+) concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of small ions including Ca(2+), Na(+), K(+) and Cl(-), as well as larger ions such as ATP(4-)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, 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"A0A1Y7VMN9_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1Y7VMN9", "type": "external" } ], "mass": 10886.0, "length": 91, "protein_name": "KRAB box domain containing 5", "gene_name": "Krbox5", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC102637366", "refseq_ac": [ { "id": "NP_001296302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296302", "type": "external" } ], "gene_names_uniprotkb": "Krbox5", "gene_names_refseq": "EG328280; Gm10037; Krabd5; Krbox5; Rslcan24", "protein_names_uniprotkb": "KRAB box domain containing 5", "protein_names_refseq": "KRAB box domain containing 5; regulator of sex-limitation candidate 24; uncharacterized protein LOC102637366", "tax_id": 10090, "disease": "", "pathway": " (mmu:102637366)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1Y7VMN9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3XA59-1", "uniprot_id": [ { "id": "LRC32_MOUSE", "url": "https://www.uniprot.org/uniprot/G3XA59", "type": "external" } ], "mass": 72418.0, "length": 663, "protein_name": "Transforming growth factor beta activator LRRC32", "gene_name": "Lrrc32", "organism": "Mouse", "refseq_name": "transforming growth factor beta activator LRRC32 precursor", "refseq_ac": [ { "id": "NP_001106850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106850", "type": "external" } ], "gene_names_uniprotkb": "Lrrc32", "gene_names_refseq": "D11S833Eh; D7H11S833E; EG434215; Garp; Lrrc32", "protein_names_uniprotkb": "Transforming growth factor beta activator LRRC32; GARP; Garpin; Glycoprotein A repetitions predominant; Leucine-rich repeat-containing protein 32", "protein_names_refseq": "garpin; glycoprotein A repetitions predominant; leucine-rich repeat-containing protein 32; transforming growth factor beta activator LRRC32 precursor; transforming growth factor beta activator LRRC32", "tax_id": 10090, "disease": "", "pathway": " (mmu:434215)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;18628982;21750661;23576681;25127859;28912269;34428180;37828378", "class_list": "", "function": "GARP is a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression Publication Status: Online-Only, [RefSeq, PubMed]; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:25127859). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:25127859, PubMed:28912269). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (By similarity). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:25127859). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (PubMed:28912269)., [UniProtKB, PubMed, UniProtKB, PubMed]; These findings suggest a role for GARP in natural and induced Treg development through activation of bound latent TGF-beta and signaling, which negatively regulates GARP expression on Tregs., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9507, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A0A0U1RQ93", "ec_number_list": [], "go_molecular_function": "GO:0050431 transforming growth factor beta binding;GO:0038023 signaling receptor activity;GO:0141069 receptor ligand inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0046007 negative regulation of activated T cell proliferation;GO:0001818 negative regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "G3XA59-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M9MMK5-1", "uniprot_id": [ { "id": "M9MMK5_MOUSE", "url": "https://www.uniprot.org/uniprot/M9MMK5", "type": "external" } ], "mass": 35682.0, "length": 318, "protein_name": "Olfactory receptor", "gene_name": "Or2t29", "organism": "Mouse", "refseq_name": "olfactory receptor 329", "refseq_ac": [ { "id": "NP_001011531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011531", "type": "external" } ], "gene_names_uniprotkb": "Or2t29; Olfr224; Olfr329-ps; Olfr329", "gene_names_refseq": "MOR275-6P; Olfr329-ps; Olfr329; Or2t29", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2NKPP-882068-883006; olfactory receptor 329, pseudogene; olfactory receptor 329; olfactory receptor MOR275-6P", "tax_id": 10090, "disease": "", "pathway": " (mmu:259148); (R-MMU-381753)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "M9MMK5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54909-1", "uniprot_id": [ { "id": "RDH16_MOUSE", "url": "https://www.uniprot.org/uniprot/O54909", "type": "external" } ], "mass": 35744.0, "length": 317, "protein_name": "Retinol dehydrogenase 16", "gene_name": "Rdh16", "organism": "Mouse", "refseq_name": "retinol dehydrogenase 16", "refseq_ac": [ { "id": "NP_033066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033066", "type": "external" } ], "gene_names_uniprotkb": "Rdh16; Crad1; Crad; Rdh1; Rdh6", "gene_names_refseq": "CRAD1; CRAD; Rdh16; Rdh6", "protein_names_uniprotkb": "Retinol dehydrogenase 16; 1.1.1.105; 1.1.1.209; 1.1.1.315; 1.1.1.53; Cis-retinol androgen dehydrogenase 1", "protein_names_refseq": "cis-retinol/androgen dehydrogenase 1; retinol dehydrogenase 16; retinol dehydrogenase 6; retinol dehydrogenase type 6", "tax_id": 10090, "disease": "chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419)", "pathway": " (mmu:19683)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11279029;15355969;16223484;21750661;34428180;9407098", "class_list": "", "function": "Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol. Oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction., [UniProtKB, UniProtKB]; Rdh1, Crad1, and other short-chain dehydrogenases/reductases, which share similar N-terminal signaling sequences such as human Rdh5 and mouse Rdh4, orient with their catalytic domains facing the cytoplasm, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.315", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.315", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.1", "type": "external" }, { "id": "1.1.1.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.66", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0047023 androsterone dehydrogenase [NAD(P)+] activity;GO:0047044 androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity;GO:0106429 11-cis-retinol dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0005789 endoplasmic reticulum membrane;GO:0031090 organelle membrane", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0042572 retinol metabolic process;GO:0042573 retinoic acid metabolic process;GO:0042904 9-cis-retinoic acid biosynthetic process;GO:0006702 androgen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O54909-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1B0GSZ2-1", "uniprot_id": [ { "id": "A0A1B0GSZ2_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A1B0GSZ2", "type": "external" } ], "mass": 35237.0, "length": 313, "protein_name": "Olfactory receptor", "gene_name": "Or51p1", "organism": "Mouse", "refseq_name": "olfactory receptor family 51 subfamily P member 1", "refseq_ac": [ { "id": "NP_001423148", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001423148", "type": "external" } ], "gene_names_uniprotkb": "Or51p1; Olfr588", "gene_names_refseq": "MOR6-1; Olfr588-ps1; Olfr588; Or51p1", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 588, pseudogene 1; olfactory receptor MOR6-1; olfactory receptor family 51 subfamily P member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:259094)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0071396 cellular response to lipid", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1B0GSZ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F8VPK0-1", "uniprot_id": [ { "id": "SKI3_MOUSE", "url": "https://www.uniprot.org/uniprot/F8VPK0", "type": "external" } ], "mass": 173942.0, "length": 1563, "protein_name": "Superkiller complex protein 3", "gene_name": "Skic3", "organism": "Mouse", "refseq_name": "superkiller complex protein 3 isoform 1", "refseq_ac": [ { "id": "NP_001074821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074821", "type": "external" } ], "gene_names_uniprotkb": "Skic3; Ttc37", "gene_names_refseq": "Ski3; Skic3; Ttc37", "protein_names_uniprotkb": "Superkiller complex protein 3; Ski3", "protein_names_refseq": "SKI3 subunit of superkiller complex protein; superkiller complex protein 3 isoform 1; superkiller complex protein 3; tetratricopeptide repeat domain 37", "tax_id": 10090, "disease": "trichohepatoenteric syndrome 1 (Disease Ontology:DOID:0111415)", "pathway": " (mmu:218343); (R-MMU-429958)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;37507081", "class_list": "", "function": "Component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation. SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling. In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0055087 Ski complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0006401 RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "F8VPK0-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CF60-1", "uniprot_id": [ { "id": "ZN263_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CF60", "type": "external" } ], "mass": 77527.0, "length": 680, "protein_name": "Zinc finger protein 263", "gene_name": "Zfp263; Znf263", "organism": "Mouse", "refseq_name": "zinc finger protein 263", "refseq_ac": [ { "id": "NP_683726", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_683726", "type": "external" } ], "gene_names_uniprotkb": "Zfp263; Znf263; FPM315; ZKSCAN12; Zfp263", "gene_names_refseq": "1200014J04Rik; NT2; Zfp263; Znf263; mFPM315", "protein_names_uniprotkb": "Zinc finger protein 263; Zinc finger protein FPM315; Zinc finger protein with KRAB and SCAN domains 12", "protein_names_refseq": "kruppel-associated box-zinc finger protein NT2; zinc finger protein 263; zinc finger protein FPM315; zinc finger protein with KRAB and SCAN domains 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:74120); (R-MMU-212436)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12024037;21750661;26089202", "class_list": "", "function": "Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor (By similarity). Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression (By similarity). Acts as a transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PXW0;Q7TMI6;Q8K439", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CF60-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X8Q1-1", "uniprot_id": [ { "id": "G3X8Q1_MOUSE", "url": "https://www.uniprot.org/uniprot/G3X8Q1", "type": "external" } ], "mass": 243172.0, "length": 2187, "protein_name": "Calcineurin-binding protein cabin-1", "gene_name": "Cabin1", "organism": "Mouse", "refseq_name": "calcineurin-binding protein cabin-1", "refseq_ac": [ { "id": "NP_766137", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766137", "type": "external" } ], "gene_names_uniprotkb": "Cabin1", "gene_names_refseq": "A330070M20Rik; Cabin1; Cain; Ppp3in", "protein_names_uniprotkb": "Calcineurin-binding protein cabin-1; Calcineurin inhibitor", "protein_names_refseq": "calcineurin inhibitor; calcineurin-binding protein cabin-1; protein phosphatase 3 inhibitor", "tax_id": 10090, "disease": "ovarian carcinoma (Disease Ontology:DOID:4001)", "pathway": " (mmu:104248); (R-MMU-2559584)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12114545;21750661;40997131", "class_list": "", "function": "Calpain-dependent cleavage activates calcineurin to mediate calcium-triggered cell death., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0003714 transcription corepressor activity;GO:0030346 protein phosphatase 2B binding;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000417 HIR complex", "go_biological_process": "GO:0006325 chromatin organization;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007165 signal transduction;GO:0043066 negative regulation of apoptotic process;GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "G3X8Q1-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E8G1-1", "uniprot_id": [ { "id": "G5E8G1_MOUSE", "url": "https://www.uniprot.org/uniprot/G5E8G1", "type": "external" } ], "mass": 35588.0, "length": 307, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r12", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor 12", "refseq_ac": [ { "id": "NP_001095049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095049", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r12", "gene_names_refseq": "EG626397; Gm6674; Vmn1r12", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r12; vomeronasal 1 receptor 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:626397)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016503 pheromone receptor activity;GO:0005550 pheromone binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G5E8G1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VB1-1", "uniprot_id": [ { "id": "Q91VB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VB1", "type": "external" } ], "mass": 26858.0, "length": 246, "protein_name": "Chymase 2, mast cell", "gene_name": "Cma2", "organism": "Mouse", "refseq_name": "mast cell protease 10 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001019885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019885", "type": "external" } ], "gene_names_uniprotkb": "Cma2", "gene_names_refseq": "Cma2; Mcp10", "protein_names_uniprotkb": "Chymase 2, mast cell", "protein_names_refseq": "mast cell protease 10 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:545055)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12231569;21750661", "class_list": "", "function": "Mast cell chymase inhibits the apolipoprotein-mediated removal of macrophage cholesterol in foam cells of apoA-I knockout mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008201 heparin binding;GO:0042277 peptide binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0030163 protein catabolic process;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91VB1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X9P6-1", "uniprot_id": [ { "id": "OBOX5_MOUSE", "url": "https://www.uniprot.org/uniprot/G3X9P6", "type": "external" } ], "mass": 32302.0, "length": 291, "protein_name": "Oocyte-specific homeobox protein 5", "gene_name": "Obox5", "organism": "Mouse", "refseq_name": "oocyte-specific homeobox protein 5", "refseq_ac": [ { "id": "NP_663755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663755", "type": "external" } ], "gene_names_uniprotkb": "Obox5", "gene_names_refseq": "Obox5", "protein_names_uniprotkb": "Oocyte-specific homeobox protein 5", "protein_names_refseq": "oocyte-specific homeobox protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:252829)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11991721;21750661;37459895", "class_list": "", "function": "Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:37459895). Together with other Obox family members, required in early two-cell stage embryos to kick-start the major ZGA wave by facilitating RNA Polymerase II 'pre-configuration', during which RNA Polymerase II relocates from the initial one-cell stage binding targets to ZGA gene promoters and distal enhancers (PubMed:37459895). Mechanistically, promotes recruitment of RNA Polymerase II from (CG-rich) non-ZGA genes to (CG-poor) ZGA genes at the two-cell stage (PubMed:37459895). Binds to regulatory DNA sequences containing a 5'-ACNCCTTTAATCCCAG-3' sequence motif (PubMed:37459895). Most maternal and zygotic Obox family proteins can compensate for one another (PubMed:37459895)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G3UZE6;G3UZS7;Q7TPZ5;Q8VHG4", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0048706 embryonic skeletal system development;GO:0160021 maternal-to-zygotic transition of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "G3X9P6-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3QK78-1", "uniprot_id": [ { "id": "J3QK78_MOUSE", "url": "https://www.uniprot.org/uniprot/J3QK78", "type": "external" } ], "mass": 55087.0, "length": 481, "protein_name": "PRAME like 42", "gene_name": "Pramel42", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC100041102", "refseq_ac": [ { "id": "NP_001230866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230866", "type": "external" } ], "gene_names_uniprotkb": "Pramel42; LOC100862115", "gene_names_refseq": "100041102; Gm3139; Pramel42", "protein_names_uniprotkb": "PRAME like 42", "protein_names_refseq": "uncharacterized protein LOC100041102", "tax_id": 10090, "disease": "", "pathway": " (mmu:100041102); (mmu:100862115)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045596 negative regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "J3QK78-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q3R6-1", "uniprot_id": [ { "id": "E9Q3R6_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q3R6", "type": "external" } ], "mass": 82380.0, "length": 731, "protein_name": "Zinc finger protein 169", "gene_name": "Zfp169", "organism": "Mouse", "refseq_name": "zinc finger protein 169 isoform a", "refseq_ac": [ { "id": "NP_001158047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158047", "type": "external" } ], "gene_names_uniprotkb": "Zfp169", "gene_names_refseq": "1700025J14Rik; 4930429A13Rik; Zfp169", "protein_names_uniprotkb": "Zinc finger protein 169", "protein_names_refseq": "zinc finger protein 169 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:67911); (R-MMU-212436)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;25605945;30779550", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9Q3R6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VFX4-1", "uniprot_id": [ { "id": "Q8VFX4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VFX4", "type": "external" } ], "mass": 34711.0, "length": 308, "protein_name": "Olfactory receptor", "gene_name": "Or5b96", "organism": "Mouse", "refseq_name": "olfactory receptor family 5 subfamily B member 96", "refseq_ac": [ { "id": "NP_666915", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666915", "type": "external" } ], "gene_names_uniprotkb": "Or5b96; Olfr1446", "gene_names_refseq": "MOR202-2; Olfr1446; Or5b96", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2RE5P-3220047-3219130; olfactory receptor 1446; olfactory receptor MOR202-2; olfactory receptor family 5 subfamily B member 96", "tax_id": 10090, "disease": "", "pathway": " (mmu:258699)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VFX4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A8N2-1", "uniprot_id": [ { "id": "A2A8N2_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A8N2", "type": "external" } ], "mass": 56823.0, "length": 498, "protein_name": "PRAME like 25", "gene_name": "Pramel25", "organism": "Mouse", "refseq_name": "oogenesin-like isoform 1", "refseq_ac": [ { "id": "NP_001007078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007078", "type": "external" } ], "gene_names_uniprotkb": "Pramel25", "gene_names_refseq": "Gm13023; MGC:91194; Pramel25", "protein_names_uniprotkb": "PRAME like 25", "protein_names_refseq": "oogenesin-like isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:194227)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045596 negative regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2A8N2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AUY4-1", "uniprot_id": [ { "id": "BAZ2B_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AUY4", "type": "external" } ], "mass": 234001.0, "length": 2123, "protein_name": "Bromodomain adjacent to zinc finger domain protein 2B", "gene_name": "Baz2b", "organism": "Mouse", "refseq_name": "bromodomain adjacent to zinc finger domain protein 2B", "refseq_ac": [ { "id": "NP_001001182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001182", "type": "external" } ], "gene_names_uniprotkb": "Baz2b", "gene_names_refseq": "5830435C13Rik; Baz2b; D2Ertd794e", "protein_names_uniprotkb": "Bromodomain adjacent to zinc finger domain protein 2B", "protein_names_refseq": "bromodomain adjacent to zinc finger domain protein 2B", "tax_id": 10090, "disease": "", "pathway": " (mmu:407823)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;32103178;35090595", "class_list": "", "function": "In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration., [RefSeq, PubMed]; Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (By similarity). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (By similarity). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (By similarity). Chromatin reader protein, involved in positively modulating the rate of age-related behavioral deterioration (PubMed:32103178). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (PubMed:32103178)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B9EKB5;Q8C0K4;Q8CFP4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A2AUY4-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3XA20-1", "uniprot_id": [ { "id": "G3XA20_MOUSE", "url": "https://www.uniprot.org/uniprot/G3XA20", "type": "external" } ], "mass": 112265.0, "length": 1042, "protein_name": "Glutamate receptor interacting protein 2", "gene_name": "Grip2", "organism": "Mouse", "refseq_name": "glutamate receptor-interacting protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001152979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152979", "type": "external" } ], "gene_names_uniprotkb": "Grip2", "gene_names_refseq": "Grip2", "protein_names_uniprotkb": "Glutamate receptor interacting protein 2", "protein_names_refseq": "glutamate receptor-interacting protein 2 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:243547); (R-MMU-416993)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "20956289;21750661;24126453;28063882;31476380;31919398", "class_list": "", "function": "GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via exocyst complex interactions., [RefSeq, PubMed]; Results indicate that loss of Grip1/2 in cerebellar Purkinje cells contributes to increased repetitive self-grooming, a core autism behavior in mice, [RefSeq, PubMed]; Study performed social behavioral testing on neuron-specific Grip1/2-double knockout (DKO) and wild type (WT) mice and determined the expression profile of key signaling proteins in AMPAR, mGluR, mTOR, and GABA pathways in brain. Data Grip1/2-mediated AMPA signaling in regulating social behaviors and disturbance of glutamate- and GABA-signaling in specialized brain regions in autism-related social behavioral deficits., [RefSeq, PubMed]; This study demonistrated that deletion of accumbal GRIP2 increases vulnerability to cue-induced cocaine relapse without altering the reinforcing properties of the drug or the response to natural rewards, [RefSeq, PubMed]; Variants of innate CD8(+) T cells are associated with Grip2 and Klf15 genes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035254 glutamate receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030425 dendrite", "go_biological_process": "GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0007219 Notch signaling pathway;GO:0045777 positive regulation of blood pressure;GO:2000463 positive regulation of excitatory postsynaptic potential;GO:0014824 artery smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "G3XA20-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3UWA2-1", "uniprot_id": [ { "id": "G3UWA2_MOUSE", "url": "https://www.uniprot.org/uniprot/G3UWA2", "type": "external" } ], "mass": 98929.0, "length": 865, "protein_name": "Vomeronasal 2, receptor 82", "gene_name": "Vmn2r82", "organism": "Mouse", "refseq_name": "vomeronasal 2, receptor 82", "refseq_ac": [ { "id": "NP_001095042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095042", "type": "external" } ], "gene_names_uniprotkb": "Vmn2r82", "gene_names_refseq": "EG624845; Vmn2r82", "protein_names_uniprotkb": "Vomeronasal 2, receptor 82", "protein_names_refseq": "vomeronasal 2, receptor 82; vomeronasal receptor Vmn2r82", "tax_id": 10090, "disease": "", "pathway": " (mmu:624845)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0038022 G protein-coupled olfactory receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "G3UWA2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z7M3-1", "uniprot_id": [ { "id": "D3Z7M3_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z7M3", "type": "external" } ], "mass": 97273.0, "length": 851, "protein_name": "Vomeronasal 2, receptor 73", "gene_name": "Vmn2r73", "organism": "Mouse", "refseq_name": "vomeronasal 2, receptor 73", "refseq_ac": [ { "id": "NP_001098656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098656", "type": "external" } ], "gene_names_uniprotkb": "Vmn2r73", "gene_names_refseq": "EG620928; Vmn2r73", "protein_names_uniprotkb": "Vomeronasal 2, receptor 73", "protein_names_refseq": "vomeronasal 2, receptor 73; vomeronasal receptor Vmn2r73", "tax_id": 10090, "disease": "", "pathway": " (mmu:620928)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z7M3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YWE3-1", "uniprot_id": [ { "id": "D3YWE3_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YWE3", "type": "external" } ], "mass": 96470.0, "length": 849, "protein_name": "Vomeronasal 2, receptor 84", "gene_name": "Vmn2r84", "organism": "Mouse", "refseq_name": "vomeronasal receptor Vmn2r84 precursor", "refseq_ac": [ { "id": "NP_001074917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074917", "type": "external" } ], "gene_names_uniprotkb": "Vmn2r84", "gene_names_refseq": "EG625068; Vmn2r84", "protein_names_uniprotkb": "Vomeronasal 2, receptor 84", "protein_names_refseq": "vomeronasal receptor Vmn2r84 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:625068)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3YWE3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D6D0-1", "uniprot_id": [ { "id": "UCP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D6D0", "type": "external" } ], "mass": 35798.0, "length": 322, "protein_name": "Mitochondrial uncoupling protein 4", "gene_name": "Slc25a27", "organism": "Mouse", "refseq_name": "mitochondrial uncoupling protein 4 isoform 1", "refseq_ac": [ { "id": "NP_082987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082987", "type": "external" } ], "gene_names_uniprotkb": "Slc25a27; UCP4", "gene_names_refseq": "3632410G24Rik; 9430092A03Rik; D530043E16Rik; Slc25a27; UCP 4; Ucp4", "protein_names_uniprotkb": "Mitochondrial uncoupling protein 4; Solute carrier family 25, member 27; UCP 4", "protein_names_refseq": "mitochondrial uncoupling protein 4 isoform 1; mitochondrial uncoupling protein 4", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:74011); (R-MMU-167826)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16775390;21750661;25237189;25535394;29315581;34887587;36537556;37688710", "class_list": "", "function": "Facilitates proton transport across the inner mitochondrial membrane and may dissipate excessive proton gradient associated with oxidative and metabolic stress at neuronal synapses. Regulates glutamate-induced proton conductance in astrocytes, shifting the energy metabolism toward aerobic glycolysis and lactate transfer to neurons for ATP synthesis. Can transport chloride ions with lower efficiency. The transport mechanism remains to be elucidated., [UniProtKB, UniProtKB, PubMed]; Our results suggested DJ-1 might regulate the expression of UCP4 by oxidation of DJ-1 and partially via NF-kappaB pathway in its protective response to oxidative stress, [RefSeq, PubMed]; Overexpression of UCP4 in astrocytic mitochondria prevents multilevel dysfunctions in a mouse model of Alzheimer's disease., [RefSeq, PubMed]; Results suggest that mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress., [RefSeq, PubMed]; UCP4 may dissipate the excessive proton gradient, which is usually associated with reactive oxygen species production., [RefSeq, PubMed]; Ucp4 Knockdown of Cerebellar Purkinje Cells Induces Bradykinesia., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0042803 protein homodimerization activity;GO:0015078 proton transmembrane transporter activity;GO:0015108 chloride transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0043025 neuronal cell body;GO:0045177 apical part of cell;GO:0043005 neuron projection", "go_biological_process": "GO:0051562 negative regulation of mitochondrial calcium ion concentration;GO:0008284 positive regulation of cell population proliferation;GO:0009409 response to cold;GO:0043066 negative regulation of apoptotic process;GO:0046324 regulation of D-glucose import", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D6D0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQV1-1", "uniprot_id": [ { "id": "Q7TQV1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQV1", "type": "external" } ], "mass": 35140.0, "length": 317, "protein_name": "Olfactory receptor", "gene_name": "Or10am5", "organism": "Mouse", "refseq_name": "olfactory receptor family 10 subfamily AM member 5", "refseq_ac": [ { "id": "NP_997019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997019", "type": "external" } ], "gene_names_uniprotkb": "Or10am5; Olfr1349", "gene_names_refseq": "MOR232-8; Olfr1349; Or10am5", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2QGBW-3245761-3244808; olfactory receptor 1349; olfactory receptor MOR232-8; olfactory receptor family 10 subfamily AM member 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:269862)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A140LJ94", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TQV1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VGH3-1", "uniprot_id": [ { "id": "Q8VGH3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VGH3", "type": "external" } ], "mass": 34915.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or6z1", "organism": "Mouse", "refseq_name": "olfactory receptor family 6 subfamily Z member 1", "refseq_ac": [ { "id": "NP_667124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_667124", "type": "external" } ], "gene_names_uniprotkb": "Or6z1; Olfr1348; Olfr5", "gene_names_refseq": "MOR103-9; Olfr1348; Or6z1", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2QGBW-3232059-3231121; olfactory receptor 1348; olfactory receptor MOR103-9; olfactory receptor family 6 subfamily Z member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:258915)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A140LIF5", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007608 sensory perception of smell;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VGH3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6XZL8-1", "uniprot_id": [ { "id": "DOT1L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6XZL8", "type": "external" } ], "mass": 165913.0, "length": 1540, "protein_name": "Histone-lysine N-methyltransferase, H3 lysine-79 specific", "gene_name": "Dot1l", "organism": "Mouse", "refseq_name": "histone-lysine N-methyltransferase, H3 lysine-79 specific", "refseq_ac": [ { "id": "NP_955354", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955354", "type": "external" } ], "gene_names_uniprotkb": "Dot1l; Dot1", "gene_names_refseq": "A630076O07; Dot1l; Dot1; KMT4; mDot1", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase, H3 lysine-79 specific; 2.1.1.360", "protein_names_refseq": "DOT1-like histone H3 methyltransferase; DOT1-like, histone H3 methyltransferase; histone H3 methyltransferase DOT1; histone methyltransferase DOT1L; histone-lysine N-methyltransferase, H3 lysine-79 specific", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); Nil-Deshwar neurodevelopmental syndrome (Disease Ontology:DOID:0070652); dilated cardiomyopathy 1A (Disease Ontology:DOID:0110425); leukemia (Disease Ontology:DOID:1240); acute biphenotypic leukemia (Disease Ontology:DOID:9953)", "pathway": " (mmu:208266); (R-MMU-3214841)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14572310;16009709;16236820;16636056;21750661;22087315;29237092;34678516;39456056", "class_list": "glycogene", "function": "DOT1L protects against podocyte injury in diabetic kidney disease through phospholipase C-like 1. Publication Status: Online-Only, [RefSeq, PubMed]; Histone H3 methyltransferase is responsible for methylating lysine27 of histone H3 at the interleukin(IL)-4-IL13 locus of T helper (Th)type 1 but not Th2 cells, [RefSeq, PubMed]; Histone methyltransferase that methylates 'Lys-79' of histone H3. Histones in nucleosomes are preferred as substrate compared to free histones. Binds to DNA (By similarity). Together with MLLT3/AF9, is involved in SCNN1A transcriptional repression following H3K79 hypermethylation at the promoter (PubMed:16236820)., [UniProtKB, PubMed, UniProtKB]; Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone., [UniProtKB, UniProtKB]; Isolation, genomic organization, alternative splicing isoforms and tissue distribution are reported for a Dot1-like homolog (mDot1) that shares with its human counterpart, hDot1L, a high degree of structural homology and specific HMT activity in vivo., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 48, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q679P5", "ec_number_list": [ { "id": "2.1.1.360", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.360", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0003676 nucleic acid binding;GO:0042054 histone methyltransferase activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0032991 protein-containing complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0046425 regulation of receptor signaling pathway via JAK-STAT;GO:0031509 subtelomeric heterochromatin formation;GO:0006281 DNA repair;GO:0008284 positive regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6XZL8-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E869-1", "uniprot_id": [ { "id": "ZN142_MOUSE", "url": "https://www.uniprot.org/uniprot/G5E869", "type": "external" } ], "mass": 206230.0, "length": 1843, "protein_name": "Zinc finger protein 142", "gene_name": "Zfp142; Znf142", "organism": "Mouse", "refseq_name": "zinc finger protein 142 isoform 2", "refseq_ac": [ { "id": "NP_084164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084164", "type": "external" } ], "gene_names_uniprotkb": "Zfp142; Znf142; Kiaa0236; Zfp142", "gene_names_refseq": "9330177B18Rik; Zfp142; Znf142; mKIAA0236", "protein_names_uniprotkb": "Zinc finger protein 142", "protein_names_refseq": "zinc finger protein 142 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:77264)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;34428180;38296634", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]; ZNF142 mutation causes sex-dependent neurologic disorder. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9PY67;Q3V1C1;Q8BWJ0;Q8BWL4;Q8CHH6", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "G5E869-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PX31-1", "uniprot_id": [ { "id": "E9PX31_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PX31", "type": "external" } ], "mass": 20158.0, "length": 176, "protein_name": "Glycosylphosphatidylinositol anchored molecule like", "gene_name": "Gml", "organism": "Mouse", "refseq_name": "hemT-3 protein isoform 1 precursor", "refseq_ac": [ { "id": "NP_001170995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170995", "type": "external" } ], "gene_names_uniprotkb": "Gml", "gene_names_refseq": "EG625599; Gml; HemT", "protein_names_uniprotkb": "Glycosylphosphatidylinositol anchored molecule like", "protein_names_refseq": "GPI anchored molecule like protein; hemT-3 protein isoform 1 precursor; hematopoietic cell transcript 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:625599)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PX31-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VGL8-1", "uniprot_id": [ { "id": "Q8VGL8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VGL8", "type": "external" } ], "mass": 34188.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or13a20", "organism": "Mouse", "refseq_name": "olfactory receptor 53", "refseq_ac": [ { "id": "NP_667171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_667171", "type": "external" } ], "gene_names_uniprotkb": "Or13a20; Olfr53", "gene_names_refseq": "IE12; MOR253-5; Olfr53; Or13a20", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PBJ9-42798103-42799038; olfactory receptor 53; olfactory receptor MOR253-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:258962)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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SLC22A14-mediated riboflavin transport is essential for spermatozoa energy generation and motility: riboflavin is the precursor of FMN and FAD, which are coenzymes of many enzymes in the TCA cycle (the citric acid cycle) in mitochondria (PubMed:33882315). Required for sperm motility and normal sperm flagellar structure (PubMed:27811987, PubMed:33882315)., [UniProtKB, PubMed, PubMed]; The role of Slc22a14 found that Slc22a14-deficient male mice showed severe infertility. Although the differentiation process in testis appeared to be normal, cauda epididymal spermatozoa in Slc22a14-/- mice showed impaired motility with abnormal tails. 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A930031C22; Zfp446", "protein_names_uniprotkb": "Zinc finger protein 446", "protein_names_refseq": "zinc finger protein 446 isoform 4", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3X9U2-1", "record_type": "protein", "filter_code": "0000000.1000100.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VFB0-1", "uniprot_id": [ { "id": "Q8VFB0_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VFB0", "type": "external" } ], "mass": 34229.0, "length": 306, "protein_name": "Olfactory receptor", "gene_name": "Or4c126", "organism": "Mouse", "refseq_name": "olfactory receptor family 4 subfamily C member 126", "refseq_ac": [ { "id": "NP_666685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666685", "type": "external" } ], "gene_names_uniprotkb": "Or4c126; Olfr1261", "gene_names_refseq": "MOR234-3; Olfr1261; Or4c126", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-51425355-51426275; olfactory receptor 1261; olfactory receptor MOR234-3; olfactory receptor family 4 subfamily C member 126", "tax_id": 10090, "disease": "", "pathway": " (mmu:258466)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Publication Status: Online-Only, [RefSeq, PubMed]; Force generating protein required for cilia beating in respiratory epithelia. Produces force towards the minus ends of microtubules. Key component of dynein, a family of motor proteins essential for movement along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of cilia., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005874 microtubule;GO:0031514 motile cilium;GO:0005930 axoneme;GO:0030286 dynein complex;GO:0097229 sperm end piece", "go_biological_process": "GO:0007018 microtubule-based movement;GO:0060294 cilium movement involved in cell motility;GO:0003341 cilium movement;GO:0090660 cerebrospinal fluid circulation;GO:0120197 mucociliary clearance", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B1AR51-1", "record_type": "protein", "filter_code": "0000000.0000111.000100.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BE20-1", "uniprot_id": [ { "id": "A2BE20_MOUSE", "url": "https://www.uniprot.org/uniprot/A2BE20", "type": "external" } ], "mass": 36720.0, "length": 318, "protein_name": "Zinc finger protein 965; Zinc finger protein 973", "gene_name": "Zfp965; Zfp973", "organism": "Mouse", "refseq_name": "KRAB box and zinc finger, C2H2 type domain containing protein-like", "refseq_ac": [ { "id": "NP_001229872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229872", "type": "external" } ], "gene_names_uniprotkb": "Zfp965; Zfp973; Zfp965", "gene_names_refseq": "6230416C02Rik; Gm14306; Gm14436; Zfp973", "protein_names_uniprotkb": "Zinc finger protein 965; Zinc finger protein 973", "protein_names_refseq": "KRAB box and zinc finger, C2H2 type domain containing protein-like; novel KRAB box and zinc finger, C2H2 type domain containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:100503949); (mmu:545490)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0002682 regulation of immune system process;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2BE20-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z5T3-1", "uniprot_id": [ { "id": "D3Z5T3_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z5T3", "type": "external" } ], "mass": 22550.0, "length": 223, "protein_name": "Keratin associated protein 10-27", "gene_name": "Krtap10-27", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC670880", "refseq_ac": [ { "id": "NP_001357745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001357745", "type": "external" } ], "gene_names_uniprotkb": "Krtap10-27; Gm9507", "gene_names_refseq": "670880; Gm9507; Krtap10-27", "protein_names_uniprotkb": "Keratin associated protein 10-27", "protein_names_refseq": "uncharacterized protein LOC670880", "tax_id": 10090, "disease": "", "pathway": " (mmu:670880); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z5T3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5R1D2-1", "uniprot_id": [ { "id": "Q5R1D2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5R1D2", "type": "external" } ], "mass": 13286.0, "length": 117, "protein_name": "T cell receptor alpha variable 15-1-DV6-1", "gene_name": "Trav15-1-dv6-1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trav15-1-dv6-1", "gene_names_refseq": "", "protein_names_uniprotkb": "T cell receptor alpha variable 15-1-DV6-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0042101 T cell receptor complex;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5R1D2-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6PWE0-1", "uniprot_id": [ { "id": "A6PWE0_MOUSE", "url": "https://www.uniprot.org/uniprot/A6PWE0", "type": "external" } ], "mass": 18414.0, "length": 161, "protein_name": "Elongin-B", "gene_name": "Elobl", "organism": "Mouse", "refseq_name": "elongin B-like", "refseq_ac": [ { "id": "NP_001347709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001347709", "type": "external" } ], "gene_names_uniprotkb": "Elobl", "gene_names_refseq": "Elobl; Gm15698; Tceb2l", "protein_names_uniprotkb": "Elongin-B; Elongin 18 kDa subunit; RNA polymerase II transcription factor SIII subunit B; SIII p18; Transcription elongation factor B polypeptide 2", "protein_names_refseq": "elongin B-like; transcription elongation factor B (SIII), polypeptide 2 (18 kDa, elongin B),-like; transcription elongation factor B (SIII), polypeptide 2 pseudogene", "tax_id": 10090, "disease": "", "pathway": " (mmu:217066)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0030891 VCB complex;GO:0031462 Cul2-RING ubiquitin ligase complex;GO:0031466 Cul5-RING ubiquitin ligase complex;GO:0070449 elongin complex", "go_biological_process": "GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway;GO:0140958 target-directed miRNA degradation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6PWE0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z4Z0-1", "uniprot_id": [ { "id": "D3Z4Z0_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z4Z0", "type": "external" } ], "mass": 48558.0, "length": 420, "protein_name": "Transcriptional adapter", "gene_name": "Tada2b", "organism": "Mouse", "refseq_name": "transcriptional adapter 2-beta", "refseq_ac": [ { "id": "NP_001163925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163925", "type": "external" } ], "gene_names_uniprotkb": "Tada2b", "gene_names_refseq": "Gm145; Tada2b", "protein_names_uniprotkb": "Transcriptional adapter", "protein_names_refseq": "transcriptional adapter 2-beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:231151); (R-MMU-5689880)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0070461 SAGA-type complex;GO:0005634 nucleus;GO:0000124 SAGA complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z4Z0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2RST1-1", "uniprot_id": [ { "id": "MGST2_MOUSE", "url": "https://www.uniprot.org/uniprot/A2RST1", "type": "external" } ], "mass": 16786.0, "length": 147, "protein_name": "Microsomal glutathione S-transferase 2", "gene_name": "Mgst2", "organism": "Mouse", "refseq_name": "microsomal glutathione S-transferase 2 isoform 1", "refseq_ac": [ { "id": "NP_778160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778160", "type": "external" } ], "gene_names_uniprotkb": "Mgst2; Gst2", "gene_names_refseq": "GST2; MGST-II; Mgst2", "protein_names_uniprotkb": "Microsomal glutathione S-transferase 2; 1.11.1.-; 2.5.1.18; 4.4.1.20; Glutathione peroxidase MGST2; Leukotriene C4 synthase MGST2; Microsomal GST-2; Microsomal GST-II; Microsomal glutathione S-transferase II", "protein_names_refseq": "glutathione peroxidase MGST2; leukotriene C4 synthase MGST2; microsomal GST-2; microsomal GST-II; microsomal glutathione S-transferase 2 isoform 1; microsomal glutathione S-transferase II", "tax_id": 10090, "disease": "", "pathway": " (mmu:211666); (R-MMU-156590); (R-MMU-5423646)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21750661;26656251", "class_list": "", "function": "Catalyzes several different glutathione-dependent reactions. Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE. Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB). Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "1.11.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.12", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "2.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0004464 leukotriene-C4 synthase activity;GO:0008047 enzyme activator activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0006629 lipid metabolic process;GO:0032496 response to lipopolysaccharide;GO:0019370 leukotriene biosynthetic process;GO:0046466 membrane lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2RST1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KL20-1", "uniprot_id": [ { "id": "OBOX7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4KL20", "type": "external" } ], "mass": 24340.0, "length": 218, "protein_name": "Oocyte-specific homeobox protein 7", "gene_name": "Obox7", "organism": "Mouse", "refseq_name": "oocyte-specific homeobox protein 7", "refseq_ac": [ { "id": "NP_001033765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033765", "type": "external" } ], "gene_names_uniprotkb": "Obox7; Gm4745", "gene_names_refseq": "EG194588; Gm4745; Obox7", "protein_names_uniprotkb": "Oocyte-specific homeobox protein 7", "protein_names_refseq": "oocyte-specific homeobox protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:194588)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;37459895", "class_list": "", "function": "Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:37459895). Together with other Obox family members, required in early two-cell stage embryos to kick-start the major ZGA wave by facilitating RNA Polymerase II 'pre-configuration', during which RNA Polymerase II relocates from the initial one-cell stage binding targets to ZGA gene promoters and distal enhancers (PubMed:37459895). Mechanistically, promotes recruitment of RNA Polymerase II from (CG-rich) non-ZGA genes to (CG-poor) ZGA genes at the two-cell stage (PubMed:37459895). Binds to regulatory DNA sequences containing a 5'-ACNCCTTTAATCCCAG-3' sequence motif (PubMed:37459895). Most maternal and zygotic Obox family proteins can compensate for one another (PubMed:37459895)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "V9GWX2", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0048706 embryonic skeletal system development;GO:0160021 maternal-to-zygotic transition of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4KL20-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VFI4-1", "uniprot_id": [ { "id": "Q8VFI4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VFI4", "type": "external" } ], "mass": 36711.0, "length": 319, "protein_name": "Olfactory receptor", "gene_name": "Or6c212", "organism": "Mouse", "refseq_name": "olfactory receptor family 6 subfamily C member 212", "refseq_ac": [ { "id": "NP_666766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666766", "type": "external" } ], "gene_names_uniprotkb": "Or6c212; Olfr805; Olfr811", "gene_names_refseq": "MOR110-4; Olfr805; Or6c212", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PULF-11402237-11401278; olfactory receptor 805; olfactory receptor MOR110-4; olfactory receptor family 6 subfamily C member 212", "tax_id": 10090, "disease": "", "pathway": " (mmu:258548)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007608 sensory perception of smell;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VFI4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A799-1", "uniprot_id": [ { "id": "A2A799_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A799", "type": "external" } ], "mass": 48135.0, "length": 407, "protein_name": "Zinc finger protein 979", "gene_name": "Zfp979", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC112422", "refseq_ac": [ { "id": "NP_659544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659544", "type": "external" } ], "gene_names_uniprotkb": "Zfp979", "gene_names_refseq": "2610305D13Rik; Ssm1b; Zfp979", "protein_names_uniprotkb": "Zinc finger protein 979", "protein_names_refseq": "uncharacterized protein LOC112422", "tax_id": 10090, "disease": "", "pathway": " (mmu:112422); (R-MMU-212436); (R-MMU-9843940)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;24803651;28464323", "class_list": "", "function": "Cloning and expression analysis of Ssm1b protein (2610305D13Rik) during mouse embryogenesis., [RefSeq, PubMed]; This work demonstrates that HRD methylation by Ssm1b is more temporally restricted during spermatogenesis compared to oogenesis, and is altered when embryonic stem cells are cultured from C3H/HeJ inner cell mass cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2A799-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A8V7-1", "uniprot_id": [ { "id": "A2A8V7_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A8V7", "type": "external" } ], "mass": 51919.0, "length": 445, "protein_name": "Zinc finger protein 981", "gene_name": "Zfp981", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC100041433", "refseq_ac": [ { "id": "NP_001230067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230067", "type": "external" } ], "gene_names_uniprotkb": "Zfp981", "gene_names_refseq": "Gm13247; Zfp981", "protein_names_uniprotkb": "Zinc finger protein 981", "protein_names_refseq": "uncharacterized protein LOC100041433", "tax_id": 10090, "disease": "", "pathway": " (mmu:100041433); (R-MMU-212436); (R-MMU-9843940)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2A8V7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2ANE0-1", "uniprot_id": [ { "id": "A2ANE0_MOUSE", "url": "https://www.uniprot.org/uniprot/A2ANE0", "type": "external" } ], "mass": 21238.0, "length": 191, "protein_name": "Reproductive homeobox 2F", "gene_name": "Rhox2f", "organism": "Mouse", "refseq_name": "reproductive homeobox 2F", "refseq_ac": [ { "id": "NP_001078825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078825", "type": "external" } ], "gene_names_uniprotkb": "Rhox2f", "gene_names_refseq": "EG434764; Rhox2.6; Rhox2e; Rhox2f", "protein_names_uniprotkb": "Reproductive homeobox 2F", "protein_names_refseq": "reproductive homeobox 2F", "tax_id": 10090, "disease": "", "pathway": " (mmu:434764)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2ANE0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AQH1-1", "uniprot_id": [ { "id": "A2AQH1_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AQH1", "type": "external" } ], "mass": 58725.0, "length": 525, "protein_name": "Ceramide kinase-like", "gene_name": "Cerkl", "organism": "Mouse", "refseq_name": "ceramide kinase-like protein", "refseq_ac": [ { "id": "NP_001041641", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041641", "type": "external" } ], "gene_names_uniprotkb": "Cerkl", "gene_names_refseq": "Cerkl; Gm1958; Rp26", "protein_names_uniprotkb": "Ceramide kinase-like", "protein_names_refseq": "ceramide kinase-like protein; retinitis pigmentosa 26 (autosomal recessive)", "tax_id": 10090, "disease": "retinitis pigmentosa 26 (Disease Ontology:DOID:0110368); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:228094)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18555012;21151604;21508105;21750661;34048907;35238502;36232896;37660443", "class_list": "", "function": "An unexpected multiplicity of CERKL transcriptional start sites (four in each species) plus a high variety of alternative splicing events primarily affecting the 5' half of the gene generate >20 fully validated mRNA isoforms in human and 23 in mouse. Publication Status: Online-Only, [RefSeq, PubMed]; CERKL alleviates ischemia reperfusion-induced nervous system injury through modulating the SIRT1/PINK1/Parkin pathway and mitophagy induction. Publication Status: Online-Only, [RefSeq, PubMed]; CERKL, a Retinal Dystrophy Gene, Regulates Mitochondrial Transport and Dynamics in Hippocampal Neurons. Publication Status: Online-Only, [RefSeq, PubMed]; CERKL, a retinal dystrophy gene, regulates mitochondrial function and dynamics in the mammalian retina., [RefSeq, PubMed]; Exacerbated response to oxidative stress in the Retinitis Pigmentosa Cerkl[KD/KO] mouse model triggers retinal degeneration pathways upon acute light stress., [RefSeq, PubMed]; The purpose of this work was to investigate alternative splicing, and the temporal and spatial expression pattern of CERKL in the mouse retina. Publication Status: Online-Only, [RefSeq, PubMed]; This work shows that CerkL does not contribute to phosphorylation of Cer and has no impact on Cer and C16-C1P levels in the retina., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001727 lipid kinase activity;GO:0046625 sphingolipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006665 sphingolipid metabolic process;GO:0030148 sphingolipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A2AQH1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AT37-1", "uniprot_id": [ { "id": "RENT2_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AT37", "type": "external" } ], "mass": 147553.0, "length": 1269, "protein_name": "Regulator of nonsense transcripts 2", "gene_name": "Upf2", "organism": "Mouse", "refseq_name": "regulator of nonsense transcripts 2", "refseq_ac": [ { "id": "NP_001074601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601", "type": "external" } ], "gene_names_uniprotkb": "Upf2; RENT2", "gene_names_refseq": "Upf2", "protein_names_uniprotkb": "Regulator of nonsense transcripts 2; Up-frameshift suppressor 2 homolog; Upf2", "protein_names_refseq": "nonsense mRNA reducing factor 2; regulator of nonsense transcripts 2; up-frameshift suppressor 2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:326622); (R-MMU-975957)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "18299400;18483223;19892989;20657840;21750661;21952136;25605945;27149095;34428180;36255229;37828378;39627609", "class_list": "", "function": "Hematopoietic-specific deletion of Upf2, a core NMD factor, led to the rapid, complete, and lasting cell-autonomous extinction of all hematopoietic stem and progenitor populations., [RefSeq, PubMed]; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA., [UniProtKB, UniProtKB]; Progression of the pluripotent epiblast depends upon the NMD factor UPF2. Erratum:[Development. 2024 Jun 15;151(12):dev203145. doi: 10.1242/dev.203145. PMID: 38912553], [RefSeq, PubMed]; Study find that loss of Upf2 during fetal liver development is incompatible with postnatal life due to failure of terminal differentiation. Moreover, deletion of Upf2 in the adult liver results in hepatosteatosis and disruption of liver homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0042162 telomeric DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0001889 liver development;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0031100 animal organ regeneration;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "A2AT37-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z150-1", "uniprot_id": [ { "id": "Q9Z150_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z150", "type": "external" } ], "mass": 49297.0, "length": 459, "protein_name": "Zinc finger and BTB domain containing 12", "gene_name": "Zbtb12", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 12 isoform 1", "refseq_ac": [ { "id": "NP_942589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942589", "type": "external" } ], "gene_names_uniprotkb": "Zbtb12", "gene_names_refseq": "Bat-9; Bat9; G10; NG35; Zbtb12", "protein_names_uniprotkb": "Zinc finger and BTB domain containing 12", "protein_names_refseq": "HLA-B-associated transcript 9; zinc finger and BTB domain-containing protein 12 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:193736)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0002682 regulation of immune system process;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9Z150-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TRV2-1", "uniprot_id": [ { "id": "Q7TRV2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TRV2", "type": "external" } ], "mass": 33805.0, "length": 306, "protein_name": "Olfactory receptor", "gene_name": "Or5p5", "organism": "Mouse", "refseq_name": "olfactory receptor family 5 subfamily P member 5", "refseq_ac": [ { "id": "NP_001005488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005488", "type": "external" } ], "gene_names_uniprotkb": "Or5p5; 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Zscan18", "protein_names_uniprotkb": "Zinc finger and SCAN domain containing 18", "protein_names_refseq": "zinc finger and SCAN domain-containing protein 18 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:232875)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PUD6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5R1I4-1", "uniprot_id": [ { "id": "Q5R1I4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5R1I4", "type": "external" } ], "mass": 12568.0, "length": 113, "protein_name": "T cell receptor alpha variable 6-2", "gene_name": "Trav6-2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trav6-2", "gene_names_refseq": "", "protein_names_uniprotkb": "T cell receptor alpha variable 6-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0042101 T cell receptor complex;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5R1I4-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8HWE5-1", "uniprot_id": [ { "id": "MILL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8HWE5", "type": "external" } ], "mass": 39224.0, "length": 355, "protein_name": "MHC class I-like protein MILL2", "gene_name": "Mill2", "organism": "Mouse", "refseq_name": "MHC class I-like protein MILL2 isoform short precursor", "refseq_ac": [ { "id": "NP_715641", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_715641", "type": "external" } ], "gene_names_uniprotkb": "Mill2", "gene_names_refseq": "Micb; Mill2", "protein_names_uniprotkb": "MHC class I-like protein MILL2; MHC class I-like located near the leukocyte receptor complex 2", "protein_names_refseq": "MHC class I-like located near the LRC, 2; MHC class I-like located near the leukocyte receptor complex 2; MHC class I-like protein MILL2 isoform short precursor; MHC class I-like protein MILL2; VMHC class I polypeptide-related sequence B", "tax_id": 10090, "disease": "", "pathway": " (mmu:243864)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12370446;15652646;16920948;18560379;21750661;26902929;30337538", "class_list": "", "function": "Analysis of functional sites in NKG2D-MICA interaction in mouse and human, [RefSeq, PubMed]; Binds to heparan sulfate proteoglycans on the surface of fibroblast (NIH-3T3) cells., [UniProtKB, PubMed]; MILL2 has a unique structural architecture and physiological role, with binding to heparan sulfate proteoglycans on fibroblasts possibly regulating cellular recruitment in biological events. Publication Status: Online-Only, [RefSeq, PubMed]; Mill1 and Mill2 genes are predicted to encode membrane glycoproteins with domain organization essentially similar to that of MHC class I heavy chains., [RefSeq, PubMed]; Our results suggest a role for the Mill proteins in cellular metabolism, with possible therapeutic significance., [RefSeq, PubMed]; Reversal of epigenetic silencing of MICA and MICB improves immune recognition and killing of Merkel cell carcinoma cells. Publication Status: Online-Only, [RefSeq, PubMed]; Two members of the mouse MILL family, MILL1 and MILL2, are GPI-anchored glycoproteins associated with beta2-microglobulin (beta2m), [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8HWE6", "ec_number_list": [], "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8HWE5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TRF6-1", "uniprot_id": [ { "id": "Q7TRF6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TRF6", "type": "external" } ], "mass": 34867.0, "length": 309, "protein_name": "Olfactory receptor", "gene_name": "Or7e165", "organism": "Mouse", "refseq_name": "olfactory receptor 58", "refseq_ac": [ { "id": "NP_035131", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035131", "type": "external" } ], "gene_names_uniprotkb": "Or7e165; Olfr58", "gene_names_refseq": "IG6; MOR146-3; MOR146-7P; Olfr58; Or7e165", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PVTD-13523015-13523944; olfactory receptor 58; olfactory receptor MOR146-7P", "tax_id": 10090, "disease": "", "pathway": " (mmu:18358)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TRF6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E897-1", "uniprot_id": [ { "id": "PLGT3_MOUSE", "url": "https://www.uniprot.org/uniprot/G5E897", "type": "external" } ], "mass": 57686.0, "length": 503, "protein_name": "Protein O-glucosyltransferase 3", "gene_name": "Poglut3", "organism": "Mouse", "refseq_name": "protein O-glucosyltransferase 3 precursor", "refseq_ac": [ { "id": "NP_997610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997610", "type": "external" } ], "gene_names_uniprotkb": "Poglut3; Kdelc2", "gene_names_refseq": "2010004J24Rik; 4833410J10Rik; Kdelc2; Poglut3", "protein_names_uniprotkb": "Protein O-glucosyltransferase 3; 2.4.1.-; 2.4.2.-; KDEL motif-containing protein 2; Protein O-xylosyltransferase POGLUT3", "protein_names_refseq": "KDEL (Lys-Asp-Glu-Leu) containing 2; KDEL motif-containing protein 2; protein O-glucosyltransferase 3 precursor; protein O-xylosyltransferase POGLUT3", "tax_id": 10090, "disease": "", "pathway": " (mmu:68304)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;27802388;30779550;30899004;34428180;38844137;40885482", "class_list": "glycogene;glycosyltransferase", "function": "Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues., [RefSeq, PubMed]; Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyze the transfer of xylose from UDP-xylose but less efficiently. Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1. May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 28, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8C6F3", "ec_number_list": [ { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.376", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.376", "type": "external" }, { "id": "2.4.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.63", "type": "external" } ], "go_molecular_function": "GO:0046527 glucosyltransferase activity;GO:0035252 UDP-xylosyltransferase activity;GO:0035251 UDP-glucosyltransferase activity;GO:0140561 EGF-domain serine glucosyltransferase activity;GO:0140562 EGF-domain serine xylosyltransferase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0012505 endomembrane system", "go_biological_process": "GO:0180059 protein O-linked glycosylation via glucose", "synthesized_glycan_count": 6710, "hit_score": 1.7, "record_id": "G5E897-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000000.100.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3UVV3-1", "uniprot_id": [ { "id": "G3UVV3_MOUSE", "url": "https://www.uniprot.org/uniprot/G3UVV3", "type": "external" } ], "mass": 245963.0, "length": 2246, "protein_name": "Zinc finger protein 407", "gene_name": "Zfp407", "organism": "Mouse", "refseq_name": "zinc finger protein 407", "refseq_ac": [ { "id": "NP_001028513", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028513", "type": "external" } ], "gene_names_uniprotkb": "Zfp407", "gene_names_refseq": "6430585N13Rik; Gm333; Gm334; Gm948; ZNF407; Zfp407", "protein_names_uniprotkb": "Zinc finger protein 407", "protein_names_refseq": "zinc finger protein 407", "tax_id": 10090, "disease": "", "pathway": " (mmu:240476)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25596527;33285243;38781157", "class_list": "", "function": "Adipocyte-specific deletion of zinc finger protein 407 results in lipodystrophy and insulin resistance in mice., [RefSeq, PubMed]; Molecular regulation of PPARgamma/RXRalpha signaling by the novel cofactor ZFP407. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptome analysis revealed that ZFP407 regulates many peroxisome proliferator-activated receptor (PPAR) gamma target genes beyond Glut4., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "G3UVV3-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A8R0-1", "uniprot_id": [ { "id": "A2A8R0_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A8R0", "type": "external" } ], "mass": 152417.0, "length": 1397, "protein_name": "Zinc finger FYVE domain-containing protein", "gene_name": "Zfyve9", "organism": "Mouse", "refseq_name": "zinc finger FYVE domain-containing protein 9 isoform 1", "refseq_ac": [ { "id": "NP_001334092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334092", "type": "external" } ], "gene_names_uniprotkb": "Zfyve9", "gene_names_refseq": "Madhip; NSP; SARA; SMADIP; Zfyve9", "protein_names_uniprotkb": "Zinc finger FYVE domain-containing protein", "protein_names_refseq": "MAD, mothers against decapentaplegic homolog interacting protein, receptor activation anchor; zinc finger FYVE domain-containing protein 9 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:230597); (R-MMU-2173789)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;19257813;21750661;25170969", "class_list": "", "function": "Osteoblast targeted expression of a mutant endofin protein lacking the pp1c binding activity results in sustained signaling of the BMP type I receptor, which increases bone formation and skeletal angiogenesis., [RefSeq, PubMed]; This study describes the expression of two SARA isoforms, SARA1 and SARA2, in mice and reports the generation and characterization of SARA mutant mice with FYVE domain deletion. The loss of SARA promoted skin tumor formation and malignant progression. 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"uniprot_canonical_ac": "K7N6B3-1", "uniprot_id": [ { "id": "K7N6B3_MOUSE", "url": "https://www.uniprot.org/uniprot/K7N6B3", "type": "external" } ], "mass": 36195.0, "length": 318, "protein_name": "Olfactory receptor", "gene_name": "Or52z13", "organism": "Mouse", "refseq_name": "olfactory receptor 618", "refseq_ac": [ { "id": "NP_667258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_667258", "type": "external" } ], "gene_names_uniprotkb": "Or52z13; Olfr618", "gene_names_refseq": "MOR31-9; Olfr618; Or52z13", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PBJ9-6320148-6321104; olfactory receptor 618; olfactory receptor MOR31-9", "tax_id": 10090, "disease": "", "pathway": " (mmu:259049)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Erratum:[Elife. 2018 Oct 11;7:e42543. doi: 10.7554/eLife.42543. 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In contrast to yeast orthologs, does not bind EIF1., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006413 translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1Y7VK80-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A9J5-1", "uniprot_id": [ { "id": "A2A9J5_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A9J5", "type": "external" } ], "mass": 75497.0, "length": 645, "protein_name": "Zinc finger protein 980", "gene_name": "Zfp980", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC100041379", "refseq_ac": [ { "id": "NP_001096628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096628", "type": "external" } ], "gene_names_uniprotkb": "Zfp980", "gene_names_refseq": "Gm13242; 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Gm5634", "gene_names_refseq": "EG434726; Fthl17L1; Fthl17b; Gm5634", "protein_names_uniprotkb": "Ferritin", "protein_names_refseq": "ferritin, heavy polypeptide-like 17 like-1", "tax_id": 10090, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:434726)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. 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Fam209", "protein_names_uniprotkb": "Protein FAM209", "protein_names_refseq": "likely orthologue of H. sapiens chromosome 20 open reading frame 106 (C20orf106); protein FAM209 precursor; protein FAM209", "tax_id": 10090, "disease": "", "pathway": " (mmu:76426)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34471926", "class_list": "", "function": "Required for sperm acrosome biogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D9T2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001669 acrosomal vesicle;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0007286 spermatid development;GO:0001675 acrosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2APA5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YX03-1", "uniprot_id": [ { "id": "D3YX03_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YX03", "type": "external" } ], "mass": 12799.0, "length": 116, "protein_name": "Defensin, alpha, 42; Defensin, alpha, 43", "gene_name": "Defa42", "organism": "Mouse", "refseq_name": "alpha-defensin 42 precursor", "refseq_ac": [ { "id": "NP_001170989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170989", "type": "external" } ], "gene_names_uniprotkb": "Defa42; Defa43; Gm7849; Gm7861", "gene_names_refseq": "Defa42; EG665927; Gm7849", "protein_names_uniprotkb": "Defensin, alpha, 42; Defensin, alpha, 43", "protein_names_refseq": "alpha-defensin 42 precursor; novel defensin-related cryptidin", "tax_id": 10090, "disease": "", "pathway": " (mmu:665927); (mmu:665956); (R-MMU-1461973); (R-MMU-1462054); (R-MMU-6798695)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0042582 azurophil granule", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3YX03-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PVJ7-1", "uniprot_id": [ { "id": "E9PVJ7_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PVJ7", "type": "external" } ], "mass": 35789.0, "length": 320, "protein_name": "Olfactory receptor", "gene_name": "Or10u3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Or10u3; 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"id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.21.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.1", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9Z1R9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A087WRP6-1", "uniprot_id": [ { "id": "A0A087WRP6_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A087WRP6", "type": "external" } ], "mass": 25534.0, "length": 222, "protein_name": "Predicted gene 28576; Predicted gene 28998", "gene_name": "Gm28576", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm28576; Gm28998", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene 28576; Predicted gene 28998", "protein_names_refseq": "", "tax_id": 10090, "disease": "spermatogenic failure 4 (Disease Ontology:DOID:0070176)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0007286 spermatid development;GO:0051321 meiotic cell cycle;GO:0035092 sperm DNA condensation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A087WRP6-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A5N3-1", "uniprot_id": [ { "id": "PAP1L_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A5N3", "type": "external" } ], "mass": 67433.0, "length": 607, "protein_name": "Polyadenylate-binding protein 1-like", "gene_name": "Pabpc1l", "organism": "Mouse", "refseq_name": "polyadenylate-binding protein 1-like", "refseq_ac": [ { "id": "NP_001107551", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107551", "type": "external" } ], "gene_names_uniprotkb": "Pabpc1l; Epab", "gene_names_refseq": "1810053B01Rik; Epab; Pabpc1l", "protein_names_uniprotkb": "Polyadenylate-binding protein 1-like; Embryonic poly(A)-binding protein; Poly(A) binding protein, cytoplasmic 1-like", "protein_names_refseq": "embryonic poly(A)-binding protein; polyadenylate-binding protein 1-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:381404)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15630085;22621333;22814100;34887587;36823316;37052235", "class_list": "", "function": "Embryonic poly(A)-binding protein interacts with translation-related proteins and undergoes phosphorylation on the serine, threonine, and tyrosine residues in the mouse oocytes and early embryos., [RefSeq, PubMed]; In mature testis the highest levels of Epab are in spermatogonia, while Pabpc1 expression is detected in spermatocytes and round spermatids., [RefSeq, PubMed]; Poly(A)-binding protein involved in oocyte maturation and early embryo development (PubMed:22621333, PubMed:37052235). It is required for cytosolic mRNA polyadenylation and translational activation of maternally stored mRNA in oocytes (PubMed:22621333)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0001556 oocyte maturation;GO:0045727 positive regulation of translation;GO:0051647 nucleus localization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A2A5N3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2BEI6-1", "uniprot_id": [ { "id": "A2BEI6_MOUSE", "url": "https://www.uniprot.org/uniprot/A2BEI6", "type": "external" } ], "mass": 41348.0, "length": 360, "protein_name": "Myb/SANT DNA binding domain containing 5 family member 10; Myb/SANT DNA binding domain containing 5 family member 7", "gene_name": "Msantd5f7", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC545637", "refseq_ac": [ { "id": "NP_001091447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091447", "type": "external" } ], "gene_names_uniprotkb": "Msantd5f7; Msantd5f10", "gene_names_refseq": "Gm11758; Msantd5f7", "protein_names_uniprotkb": "Myb/SANT DNA binding domain containing 5 family member 10; Myb/SANT DNA binding domain containing 5 family member 7", "protein_names_refseq": "uncharacterized protein LOC545637", "tax_id": 10090, "disease": "", "pathway": " (mmu:545637); (mmu:667780)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "This gene belongs to a family of related genes tandemly arranged in two clusters on chromosome 4. This family, which appears to be mouse-specific and composed of multiple highly similar members, is supported by limited transcript data. Members of the family maintain an intact open reading frame although the encoded protein has no known function. This gene is supported by transcript alignments. [provided by RefSeq, May 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2BEI6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E0CYR6-1", "uniprot_id": [ { "id": "NT8F7_MOUSE", "url": "https://www.uniprot.org/uniprot/E0CYR6", "type": "external" } ], "mass": 26101.0, "length": 227, "protein_name": "N-acetyltransferase family 8 member 7", "gene_name": "Nat8f7", "organism": "Mouse", "refseq_name": "N-acetyltransferase family 8 member 7", "refseq_ac": [ { "id": "NP_001240839", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240839", "type": "external" } ], "gene_names_uniprotkb": "Nat8f7", "gene_names_refseq": "100043497; Cml3; Gm4477; Nat8f3; Nat8f7", "protein_names_uniprotkb": "N-acetyltransferase family 8 member 7; 2.3.1.48", "protein_names_refseq": "Camello-like protein 3; N-acetyltransferase CML3; N-acetyltransferase family 8 member 3; N-acetyltransferase family 8 member 7; camello-like 3-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:100043497)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25123547;34428180", "class_list": "", "function": "Has histone acetyltransferase activity in vitro, with specificity for histone H4., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" }, { "id": "4.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0047198 L-cysteine-S-conjugate N-acetyltransferase activity;GO:0010485 histone H4 acetyltransferase activity;GO:0008080 N-acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E0CYR6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PXX9-1", "uniprot_id": [ { "id": "S28A1_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PXX9", "type": "external" } ], "mass": 71174.0, "length": 648, "protein_name": "Sodium/nucleoside cotransporter 1", "gene_name": "Slc28a1", "organism": "Mouse", "refseq_name": "sodium/nucleoside cotransporter 1", "refseq_ac": [ { "id": "NP_001004184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004184", "type": "external" } ], "gene_names_uniprotkb": "Slc28a1", "gene_names_refseq": "CNT 1; Cnt1; Slc28a1", "protein_names_uniprotkb": "Sodium/nucleoside cotransporter 1; CNT 1; Concentrative nucleoside transporter 1; Na(+)/nucleoside cotransporter 1; Sodium-coupled nucleoside transporter 1; Solute carrier family 28 member 1", "protein_names_refseq": "Na(+)/nucleoside cotransporter 1; concentrative nucleoside transporter 1; sodium-coupled nucleoside transporter 1; sodium/nucleoside cotransporter 1; solute carrier family 28 member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:434203); (R-MMU-83936)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "19228884", "class_list": "", "function": "Sodium and pyrimidine nucleoside symporter of the plasma membrane that imports uridine, thymidine and cytidine into cells by coupling their transport to the transmembrane sodium electrochemical gradient. Also transports adenosine, an atypical substrate transported with high apparent affinity, but low maximum velocity. Therefore, exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit). Involved in renal nucleoside (re)absorption., [UniProtKB, UniProtKB]; The concentrative nucleoside transporter-1 (CNT1) promoter was characterized with respect to DNA response elements and their binding factors are reported., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6P8I9", "ec_number_list": [], "go_molecular_function": "GO:0015213 uridine transmembrane transporter activity;GO:0005350 pyrimidine nucleobase transmembrane transporter activity;GO:0015389 pyrimidine- and adenosine-specific:sodium symporter activity;GO:1901474 azole transmembrane transporter activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0015861 cytidine transport;GO:0015862 uridine transmembrane transport;GO:0015855 pyrimidine nucleobase transport;GO:1901642 nucleoside transmembrane transport;GO:0072531 pyrimidine-containing compound transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PXX9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q4X7-1", "uniprot_id": [ { "id": "E9Q4X7_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q4X7", "type": "external" } ], "mass": 35571.0, "length": 319, "protein_name": "Olfactory receptor family 51 subfamily AF member 1", "gene_name": "Or51af1", "organism": "Mouse", "refseq_name": "olfactory receptor 609", "refseq_ac": [ { "id": "NP_667293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_667293", "type": "external" } ], "gene_names_uniprotkb": "Or51af1; Olfr609", "gene_names_refseq": "MOR9-1; Olfr609; Or51af1", "protein_names_uniprotkb": "Olfactory receptor family 51 subfamily AF member 1", "protein_names_refseq": "GA_x6K02T2PBJ9-6207735-6206776; olfactory receptor 609; olfactory receptor MOR9-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:259086)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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[provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TRX9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TRY2-1", "uniprot_id": [ { "id": "Q7TRY2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TRY2", "type": "external" } ], "mass": 34662.0, "length": 314, "protein_name": "Olfactory receptor", "gene_name": "Or2z8", "organism": "Mouse", "refseq_name": "olfactory receptor 372", "refseq_ac": [ { "id": "NP_997438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997438", "type": "external" } ], "gene_names_uniprotkb": "Or2z8; Olfr372", "gene_names_refseq": "MOR282-1; Olfr372; Or2z8", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 372", "tax_id": 10090, "disease": "", "pathway": " (mmu:404315)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; This odorant receptor, Olfr170, responds to the odorant isoamyl acetate in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VGL6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80YX8-1", "uniprot_id": [ { "id": "Q80YX8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80YX8", "type": "external" } ], "mass": 21165.0, "length": 181, "protein_name": "Major urinary protein 21", "gene_name": "Mup21", "organism": "Mouse", "refseq_name": "major urinary protein 26 precursor", "refseq_ac": [ { "id": "NP_001009550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009550", "type": "external" } ], "gene_names_uniprotkb": "Mup21", "gene_names_refseq": "Gm11208; Mup21; Mup26; Mup; bM64F17.1; bM64F17.4", "protein_names_uniprotkb": "Major urinary protein 21", "protein_names_refseq": "major urinary protein 26 precursor; major urinary protein 26", "tax_id": 10090, "disease": "", "pathway": " (mmu:381531)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036094 small molecule binding;GO:0005550 pheromone binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80YX8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZT7-1", "uniprot_id": [ { "id": "PA2G3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZT7", "type": "external" } ], "mass": 56687.0, "length": 504, "protein_name": "Group 3 secretory phospholipase A2", "gene_name": "Pla2g3", "organism": "Mouse", "refseq_name": "group 3 secretory phospholipase A2 precursor", "refseq_ac": [ { "id": "NP_766379", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766379", "type": "external" } ], "gene_names_uniprotkb": "Pla2g3", "gene_names_refseq": "Pla2g3; sPLA2-III", "protein_names_uniprotkb": "Group 3 secretory phospholipase A2; 3.1.1.4; GIII sPLA2; Group III secretory phospholipase A2; Phosphatidylcholine 2-acylhydrolase 3; sPLA2-III", "protein_names_refseq": "GIII sPLA2; group 3 secretory phospholipase A2 precursor; group 3 secretory phospholipase A2; group III secretory phospholipase A2; phosphatidylcholine 2-acylhydrolase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:237625); (R-MMU-1482788); (R-MMU-1482839); (R-MMU-1482925)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "15863501;17868035;19371233;20424323;23624557;28947740;34237486;34359862", "class_list": "", "function": "Data indicate a PLA2G3-lipocalin-type PGD2 synthase (L-PGDS)-PGD2 receptor DP1 loop that drives mast cell maturation., [RefSeq, PubMed]; Mast Cell-Specific Deletion of Group III Secreted Phospholipase A2 Impairs Mast Cell Maturation and Functions. Publication Status: Online-Only, [RefSeq, PubMed]; SPLA(2)-III may have a role in cancer development by stimulating tumor cell growth and angiogenesis, [RefSeq, PubMed]; Secreted PLA2-III is a possible therapeutic target to treat neuropathic pain., [RefSeq, PubMed]; Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids without apparent head group selectivity (PubMed:20424323). Contributes to phospholipid remodeling of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. Hydrolyzes LDL phospholipids releasing unsaturated fatty acids that regulate macrophage differentiation toward foam cells (By similarity). May act in an autocrine and paracrine manner (PubMed:23624557). Secreted by immature mast cells, acts on nearby fibroblasts upstream to PTDGS to synthesize prostaglandin D2 (PGD2), which in turn promotes mast cell maturation and degranulation via PTGDR (PubMed:23624557). Secreted by epididymal epithelium, acts on immature sperm cells within the duct, modulating the degree of unsaturation of the fatty acyl components of phosphatidylcholines required for acrosome assembly and sperm cell motility (PubMed:20424323). Facilitates the replacement of fatty acyl chains in phosphatidylcholines in sperm membranes from omega-6 and omega-9 to omega-3 polyunsaturated fatty acids (PUFAs) (PubMed:20424323). Coupled to lipoxygenase pathway, may process omega-6 PUFAs to generate oxygenated lipid mediators in the male reproductive tract (PubMed:20424323). At pericentrosomal preciliary compartment, negatively regulates ciliogenesis likely by regulating endocytotic recycling of ciliary membrane protein (By similarity). Coupled to cyclooxygenase pathway provides arachidonate to generate prostaglandin E2 (PGE2), a potent immunomodulatory lipid in inflammation and tumorigenesis (By similarity). At colonic epithelial barrier, preferentially hydrolyzes phospholipids having arachidonate and docosahexaenoate at sn-2 position, contributing to the generation of oxygenated metabolites involved in colonic stem cell homeostasis (PubMed:28947740). Releases C16:0 and C18:0 lysophosphatidylcholine subclasses from neuron plasma membranes and promotes neurite outgrowth and neuron survival (PubMed:17868035)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The atypical sPLA2 family member sPLA2-III has a role in epididymal lipid homeostasis and its perturbation may lead to sperm dysfunction, [RefSeq, PubMed]; This study showed that endogenous group III sPLA2 (PLA2G3) is expressed in mouse skin and that transgenic mice overexpressing human PLA2G3 spontaneously develop skin inflammation. 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Olfr653", "gene_names_refseq": "MOR33-1; Olfr653; Or52d3; Ors19", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PBJ9-7206970-7207923; odorant receptor S19; olfactory receptor 653; olfactory receptor MOR33-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:57250)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins. Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure. Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TXY2;Q99LS5;Q9D7D9", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0061709 reticulophagy;GO:0106300 protein-DNA covalent cross-linking repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q137-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q4G0-1", "uniprot_id": [ { "id": "E9Q4G0_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q4G0", "type": "external" } ], "mass": 36056.0, "length": 321, "protein_name": "Olfactory receptor", "gene_name": "Or6k2", "organism": "Mouse", "refseq_name": "olfactory receptor 420", "refseq_ac": [ { "id": "NP_666417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666417", "type": "external" } ], "gene_names_uniprotkb": "Or6k2; Olfr420", "gene_names_refseq": "MOR105-10; Olfr420; Or6k2", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2P20D-20995211-20994246; olfactory receptor 420; olfactory receptor MOR105-10", "tax_id": 10090, "disease": "", "pathway": " (mmu:258302)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. 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Tmem29", "gene_names_refseq": "2700081K05Rik; 6330540D07Rik; CXorf44-like; Tmem29; Vcf2", "protein_names_uniprotkb": "VCP nuclear cofactor family member 2", "protein_names_refseq": "protein VCF2 isoform a; transmembrane protein 29", "tax_id": 10090, "disease": "", "pathway": " (mmu:382245)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2ANF5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SZ99-1", "uniprot_id": [ { "id": "TRI38_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SZ99", "type": "external" } ], "mass": 54430.0, "length": 471, "protein_name": "E3 ubiquitin-protein ligase TRIM38", "gene_name": "Trim38", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase TRIM38", "refseq_ac": [ { "id": "NP_001025106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025106", "type": "external" } ], "gene_names_uniprotkb": "Trim38", "gene_names_refseq": "Gm23; Trim38", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM38; 2.3.2.-; 2.3.2.27; E3 SUMO-protein ligase TRIM38; Tripartite motif-containing protein 38", "protein_names_refseq": "E3 SUMO-protein ligase TRIM38; E3 ubiquitin-protein ligase TRIM38; RING finger protein 15; tripartite motif-containing protein 38; zinc finger protein RoRet", "tax_id": 10090, "disease": "", "pathway": " (mmu:214158)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;22323536;22539786;26392463;27637147;29753717", "class_list": "", "function": "Data show that tripartite motif-containing 38 protein (Trim38) deficiency potentiates toll like receptors TLR3/4-mediated signaling in primary immune cells., [RefSeq, PubMed]; E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity (PubMed:22539786, PubMed:26392463, PubMed:27637147). Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation (PubMed:22539786). Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling (PubMed:26392463). Acts as a positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus (PubMed:27637147). Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Our data suggest that TRIM38 plays a critical role in bone remodeling as a negative regulator of NF-kappaB in both osteoclast and osteoblast differentiation., [RefSeq, PubMed]; TRIM38 is a negative regulator for Toll like receptor (TLR) and retinoic acid-inducible gene (RIG)-I-mediated IFN-beta production by targeting Nck-associated protein NAP1 for ubiquitination and subsequent proteasome-mediated degradation., [RefSeq, PubMed]; Ur findings defined a novel function for TRIM38 to prevent excessive TLR-induced inflammatory responses through proteasomal degradation of TRAF6., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EKD3", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0046596 regulation of viral entry into host cell;GO:0032648 regulation of interferon-beta production;GO:0016925 protein sumoylation;GO:0045087 innate immune response;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5SZ99-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2ART4-1", "uniprot_id": [ { "id": "A2ART4_MOUSE", "url": "https://www.uniprot.org/uniprot/A2ART4", "type": "external" } ], "mass": 57790.0, "length": 498, "protein_name": "Predicted gene 11007; Predicted gene 14308; Predicted gene 14434; Predicted gene 2007; Predicted gene 2026; Predicted gene 4631; Predicted gene 4724", "gene_name": "Gm14305; Gm14410; Gm2026; Gm4631", "organism": "Mouse", "refseq_name": "KRAB box and zinc finger, C2H2 type domain containing", "refseq_ac": [ { "id": "NP_001092819", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092819", "type": "external" } ], "gene_names_uniprotkb": "Gm14305; Gm14410; Gm2026; Gm4631; Gm11007; Gm14308; Gm14434; Gm2007; Gm2026; Gm4724", "gene_names_refseq": "Gm14308", "protein_names_uniprotkb": "Predicted gene 11007; Predicted gene 14308; Predicted gene 14434; Predicted gene 2007; Predicted gene 2026; Predicted gene 4631; Predicted gene 4724", "protein_names_refseq": "KRAB box and zinc finger, C2H2 type domain containing", "tax_id": 10090, "disease": "", "pathway": " (mmu:100039060); (mmu:100043381); (mmu:100043387); (mmu:100043403); (mmu:100043915); (mmu:627914); (mmu:668039)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2ART4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DFW5-1", "uniprot_id": [ { "id": "AT11B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6DFW5", "type": "external" } ], "mass": 133536.0, "length": 1175, "protein_name": "Phospholipid-transporting ATPase IF", "gene_name": "Atp11b", "organism": "Mouse", "refseq_name": "phospholipid-transporting ATPase IF", "refseq_ac": [ { "id": "NP_083846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083846", "type": "external" } ], "gene_names_uniprotkb": "Atp11b", "gene_names_refseq": "1110019I14Rik; ATPIF; ATPIR; Atp11b; mKIAA0956", "protein_names_uniprotkb": "Phospholipid-transporting ATPase IF; 7.6.2.1; ATPase class VI type 11B; P4-ATPase flippase complex alpha subunit ATP11B", "protein_names_refseq": "P4-ATPase flippase complex alpha subunit ATP11B; phospholipid-transporting ATPase IF; probable phospholipid-transporting ATPase IF", "tax_id": 10090, "disease": "", "pathway": " (mmu:76295); (R-MMU-6798695); (R-MMU-936837)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21750661;30018401", "class_list": "", "function": "Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes. May contribute to the maintenance of membrane lipid asymmetry in endosome compartment., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0055037 recycling endosome", "go_biological_process": "GO:0045332 phospholipid translocation;GO:0015914 phospholipid transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6DFW5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A140LHX2-1", "uniprot_id": [ { "id": "A0A140LHX2_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A140LHX2", "type": "external" } ], "mass": 34940.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or4f14c", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Or4f14c; Olfr1315", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A140LHX2-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VFQ6-1", "uniprot_id": [ { "id": "Q8VFQ6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VFQ6", "type": "external" } ], "mass": 34942.0, "length": 315, "protein_name": "Olfactory receptor", "gene_name": "Or5b123", "organism": "Mouse", "refseq_name": "olfactory receptor 1487", "refseq_ac": [ { "id": "NP_666847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666847", "type": "external" } ], "gene_names_uniprotkb": "Or5b123; Olfr1487", "gene_names_refseq": "MOR202-18; Olfr1487; Or5b123", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2RE5P-3951719-3952666; olfactory receptor 1487; olfactory receptor MOR202-18", "tax_id": 10090, "disease": "", "pathway": " (mmu:258629)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VFQ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCE9-1", "uniprot_id": [ { "id": "IRGM3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCE9", "type": "external" } ], "mass": 48494.0, "length": 423, "protein_name": "Immunity-related GTPase family M protein 3", "gene_name": "Igtp", "organism": "Mouse", "refseq_name": "immunity-related GTPase family M protein 3", "refseq_ac": [ { "id": "NP_061208", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061208", "type": "external" } ], "gene_names_uniprotkb": "Igtp; Irgm3", "gene_names_refseq": "Igtp; Irgm3", "protein_names_uniprotkb": "Immunity-related GTPase family M protein 3; 3.6.5.-; Interferon gamma-induced GTPase", "protein_names_refseq": "immunity-related GTPase family M protein 3", "tax_id": 10090, "disease": "inflammatory bowel disease 19 (Disease Ontology:DOID:0110890); tuberculosis (Disease Ontology:DOID:399)", "pathway": " (mmu:16145)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10639151;11500431;12438372;16940170;18765738;21750661;21981022;22892676;23785284;25644000;36629440;8702776;9099712", "class_list": "", "function": "Immunity-related GTPase that plays important roles in host resistance to acute infection by protozoan, such as Toxoplasma gondii and Leishmania major (PubMed:10639151, PubMed:11500431, PubMed:12438372, PubMed:16940170, PubMed:18765738). Acts as a dynamin-like protein that binds to intracellular membranes and promotes remodeling and trafficking of those membranes (By similarity). Acts predominantly to restrict acute protozoan infection: expression is required in both hematopoietic and non-hematopoietic cellular compartments and is dependent on Stat1 (PubMed:12438372). Only plays a partial role in the control of latent Toxoplasma infection (PubMed:12438372). Involved in the clearance of acute protozoan infections by regulating autophagy, possibly by promoting the fusion of phagosomes with lysosomes for efficient degradation of vacuoles containing parasites (PubMed:16940170). Probably involved in membrane disruption of parasite-containing vacuoles (PubMed:18765738). In addition to its role in resistance to acute infection by protozoan, also acts as a negative regulator of the integrated stress response (ISR) following coxsackievirus B3 infection (PubMed:21981022). Promotes differentiation of activated CD8(+) T-cells (PubMed:25644000)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "J7PDL1;Q8C2M8", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0043374 CD8-positive, alpha-beta T cell differentiation;GO:0044546 NLRP3 inflammasome complex assembly;GO:1901526 positive regulation of mitophagy;GO:0000045 autophagosome assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9DCE9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R281-1", "uniprot_id": [ { "id": "Q8R281_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R281", "type": "external" } ], "mass": 36070.0, "length": 312, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r200", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor 200", "refseq_ac": [ { "id": "NP_598973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598973", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r200", "gene_names_refseq": "V1rh3; Vmn1r200", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r200; vomeronasal 1 receptor 200; vomeronasal 1 receptor, H3", "tax_id": 10090, "disease": "", "pathway": " (mmu:171246)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016503 pheromone receptor activity;GO:0005550 pheromone binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R281-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIC0-1", "uniprot_id": [ { "id": "Q8VIC0_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VIC0", "type": "external" } ], "mass": 35224.0, "length": 307, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r71", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor, E13", "refseq_ac": [ { "id": "NP_665847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665847", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r71", "gene_names_refseq": "V1re13; Vmn1r71", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r71; vomeronasal 1 receptor, E13", "tax_id": 10090, "disease": "", "pathway": " (mmu:252910)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Putative pheromone receptor., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016503 pheromone receptor activity;GO:0005550 pheromone binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VIC0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IQX8-1", "uniprot_id": [ { "id": "ZN219_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6IQX8", "type": "external" } ], "mass": 77796.0, "length": 726, "protein_name": "Zinc finger protein 219", "gene_name": "Zfp219; Znf219", "organism": "Mouse", "refseq_name": "zinc finger protein 219 isoform 1", "refseq_ac": [ { "id": "NP_001240623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240623", "type": "external" } ], "gene_names_uniprotkb": "Zfp219; Znf219; Zfp219", "gene_names_refseq": "2010302A17Rik; Zfp219; Znf219", "protein_names_uniprotkb": "Zinc finger protein 219", "protein_names_refseq": "zinc finger protein 219 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69890)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20940257;21183079;21750661;36076959", "class_list": "", "function": "Interplay between the Chd4/NuRD Complex and the Transcription Factor Znf219 Controls Cardiac Cell Identity. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional regulator (PubMed:20940257). Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3' (PubMed:20940257). Binds to the HMGN1 promoter and may repress HMGN1 expression (By similarity). Regulates SNCA expression in primary cortical neurons (By similarity). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (PubMed:20940257). Plays a role in chondrocyte differentiation (PubMed:20940257)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q921W9;Q924S6;Q9CVF3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6IQX8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5NCC7-1", "uniprot_id": [ { "id": "Q5NCC7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5NCC7", "type": "external" } ], "mass": 36976.0, "length": 333, "protein_name": "Olfactory receptor", "gene_name": "Or2ab1", "organism": "Mouse", "refseq_name": "olfactory receptor 324", "refseq_ac": [ { "id": "NP_001011743", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011743", "type": "external" } ], "gene_names_uniprotkb": "Or2ab1; Olfr324", "gene_names_refseq": "MOR102-2; Olfr324; Or2ab1", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2NKPP-822947-822000; olfactory receptor 324; olfactory receptor MOR102-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:257892)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Possible taste receptor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5NCC7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQV7-1", "uniprot_id": [ { "id": "Q7TQV7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQV7", "type": "external" } ], "mass": 35636.0, "length": 317, "protein_name": "Olfactory receptor family 10 subfamily AK member 11", "gene_name": "Or10ak11", "organism": "Mouse", "refseq_name": "olfactory receptor 1333", "refseq_ac": [ { "id": "NP_997040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997040", "type": "external" } ], "gene_names_uniprotkb": "Or10ak11; Olfr1333", "gene_names_refseq": "GA_x5J8B7TQTH0-2-774; MOR259-11; MOR259-6; Olfr1333; Or10ak11", "protein_names_uniprotkb": "Olfactory receptor family 10 subfamily AK member 11", "protein_names_refseq": "GA_x6K02T2QD9B-18703033-18703986; olfactory receptor 1333", "tax_id": 10090, "disease": "", "pathway": " (mmu:258265)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); anterior uveitis (Disease Ontology:DOID:1407); Takayasu's arteritis (Disease Ontology:DOID:2508); synovitis (Disease Ontology:DOID:2703); dermatitis (Disease Ontology:DOID:2723); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); cerebral infarction (Disease Ontology:DOID:3526); acute retinal necrosis syndrome (Disease Ontology:DOID:3611); thrombophlebitis (Disease Ontology:DOID:3875); tuberculosis (Disease Ontology:DOID:399); cervical cancer (Disease Ontology:DOID:4362); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); uveal melanoma (Disease Ontology:DOID:6039); reactive arthritis (Disease Ontology:DOID:6196); ankylosing spondylitis (Disease Ontology:DOID:7147); diabetic retinopathy (Disease Ontology:DOID:8947); allergic asthma (Disease Ontology:DOID:9415); Meniere's disease (Disease Ontology:DOID:9849); alopecia (Disease Ontology:DOID:987); mitral valve prolapse (Disease Ontology:DOID:988)", "pathway": " (R-MMU-1236974); (R-MMU-1236977); (R-MMU-198933); (R-MMU-6798695); (R-MMU-983170)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 39, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046978 TAP1 binding;GO:0046979 TAP2 binding;GO:0005102 signaling receptor binding;GO:0051087 protein-folding chaperone binding;GO:0030881 beta-2-microglobulin binding", "go_cellular_component": "GO:0016020 membrane;GO:0032398 MHC class Ib protein complex;GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0006955 immune response;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0001916 positive regulation of T cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O19443-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true } ]