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This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. 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Olfr1157", "gene_names_refseq": "MOR174-1; Olfr1157; Or5l14", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-49446395-49445457; olfactory receptor 1157; olfactory receptor MOR174-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:258846)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. 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Vmn1r86", "gene_names_refseq": "Vmn1r88", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomeronasal 1 receptor Vmn1r88; vomeronasal 1 receptor, 88", "tax_id": 10090, "disease": "", "pathway": " (mmu:100312474)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Putative pheromone receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q235-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q8I5-1", "uniprot_id": [ { "id": "E9Q8I5_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q8I5", "type": "external" } ], "mass": 73134.0, "length": 642, "protein_name": "Zinc finger protein 108", "gene_name": "Zfp108", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zfp108", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein 108", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q8I5-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "K7N678-1", "uniprot_id": [ { "id": "K7N678_MOUSE", "url": "https://www.uniprot.org/uniprot/K7N678", "type": "external" } ], "mass": 34991.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or8c15", "organism": "Mouse", "refseq_name": "olfactory receptor 893", "refseq_ac": [ { "id": "NP_666448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666448", "type": "external" } ], "gene_names_uniprotkb": "Or8c15; Olfr893", "gene_names_refseq": "MOR170-11; Olfr893; Or8c15", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PVTD-31889215-31890153; olfactory receptor 893; olfactory receptor MOR170-11", "tax_id": 10090, "disease": "", "pathway": " (mmu:258333)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "K7N678-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PZ11-1", "uniprot_id": [ { "id": "E9PZ11_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PZ11", "type": "external" } ], "mass": 80787.0, "length": 729, "protein_name": "Zinc finger and BTB domain containing 47", "gene_name": "Zbtb47", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 47", "refseq_ac": [ { "id": "NP_001160116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160116", "type": "external" } ], "gene_names_uniprotkb": "Zbtb47; Zfp651", "gene_names_refseq": "4732420M22Rik; Zbtb47; Zfp651", "protein_names_uniprotkb": "Zinc finger and BTB domain containing 47", "protein_names_refseq": "zinc finger and BTB domain-containing protein 47; zinc finger protein 651", "tax_id": 10090, "disease": "", "pathway": " (mmu:270210)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E9PZ11-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PWH2-1", "uniprot_id": [ { "id": "E9PWH2_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PWH2", "type": "external" } ], "mass": 131469.0, "length": 1175, "protein_name": "Caspase recruitment domain family, member 6", "gene_name": "Card6", "organism": "Mouse", "refseq_name": "caspase recruitment domain-containing protein 6", "refseq_ac": [ { "id": "NP_001156610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156610", "type": "external" } ], "gene_names_uniprotkb": "Card6", "gene_names_refseq": "Card6; D730008L15", "protein_names_uniprotkb": "Caspase recruitment domain family, member 6", "protein_names_refseq": "caspase recruitment domain-containing protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:239319)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16418290;21750661;24777975;25428506;29729191;29958938;31841440;32102753;32317187", "class_list": "", "function": "CARD6 is a novel protective factor against hepatic I/R injury that suppresses inflammation and liver cell death by inhibiting the ASK1 signaling pathway. Erratum:[J Hepatol. 2019 Mar;70(3):578-580. PMID: 30616986], [RefSeq, PubMed]; CARD6 is a regulator of NF-kappaB activation that modulates the functions of RICK protein, [RefSeq, PubMed]; CARD6 protects against collagen-induced rheumatoid arthritis in mice through attenuating the inflammatory response and joint destruction via suppression of TNFR1/TRAF2 signaling., [RefSeq, PubMed]; Gain-of-function and loss-of-function Card6 mouse models demonstrated that Card6 protected mice from insulin resistance, hepatic steatosis, and inflammatory responses upon high-fat diet administration. Mechanistically, Card6 interacted with and inhibited apoptosis signal-regulating kinase 1 (Ask1) and its subsequent downstream c-Jun N-terminal kinase/p38 signaling., [RefSeq, PubMed]; Increased macrophage activation mediated by caspase recruitment domain 6 knockdown through negatively targeting AMPK., [RefSeq, PubMed]; Targeting CARD6 attenuates spinal cord injury (SCI) in mice through inhibiting apoptosis, inflammation and oxidative stress associated ROS production., [RefSeq, PubMed]; These data indicated that CARD6 serves as a novel cardioprotective factor via negative regulation of MEK kinase-1-dependent MEK-ERK1/2 and JNK1/2 signaling, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0042981 regulation of apoptotic process;GO:0033344 cholesterol efflux;GO:0070508 cholesterol import;GO:0043122 regulation of canonical NF-kappaB signal transduction;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "E9PWH2-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A8M8-1", "uniprot_id": [ { "id": "A2A8M8_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A8M8", "type": "external" } ], "mass": 54471.0, "length": 474, "protein_name": "PRAME like 11", "gene_name": "Pramel11", "organism": "Mouse", "refseq_name": "PRAME family member 6 isoform 1", "refseq_ac": [ { "id": "NP_001393669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001393669", "type": "external" } ], "gene_names_uniprotkb": "Pramel11", "gene_names_refseq": "Gm13099; Pramef6; Pramel11", "protein_names_uniprotkb": "PRAME like 11", "protein_names_refseq": "PRAME family member 6 isoform 1; PRAME family member 6", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045596 negative regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2A8M8-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q1W3-1", "uniprot_id": [ { "id": "E9Q1W3_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q1W3", "type": "external" } ], "mass": 828662.0, "length": 7152, "protein_name": "Nebulin", "gene_name": "Neb", "organism": "Mouse", "refseq_name": "nebulin", "refseq_ac": [ { "id": "NP_035019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035019", "type": "external" } ], "gene_names_uniprotkb": "Neb", "gene_names_refseq": "Neb", "protein_names_uniprotkb": "Nebulin", "protein_names_refseq": "nebulin", "tax_id": 10090, "disease": "arthrogryposis multiplex congenita-6 (Disease Ontology:DOID:0070336); nemaline myopathy 2 (Disease Ontology:DOID:0110928); nemaline myopathy (Disease Ontology:DOID:3191)", "pathway": " (mmu:17996); (R-MMU-390522)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;35175800;36528760;37422147;39927985", "class_list": "", "function": "Aberrations in Energetic Metabolism and Stress-Related Pathways Contribute to Pathophysiology in the Neb Conditional Knockout Mouse Model of Nemaline Myopathy., [RefSeq, PubMed]; NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy. 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"type": "external" } ], "gene_names_uniprotkb": "Kcnt2; Slick; Slo2.2", "gene_names_refseq": "E330038N15Rik; Kcnt2; Slick", "protein_names_uniprotkb": "Potassium channel subfamily T member 2; Sequence like an intermediate conductance potassium channel subunit; Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1", "protein_names_refseq": "potassium channel subfamily T member 2; sequence like an intermediate conductance potassium channel subunit; sodium and chloride-activated ATP-sensitive potassium channel Slo2.1; sodium- and chloride-activated ATP-sensitive potassium channel subunit", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 57 (Disease Ontology:DOID:0080284); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:240776)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17344399;21750661;25428506;26587966;26845140;28943756;29124216", "class_list": "", "function": "Slick (Slo2.1) is required for both volatile anesthetics-stimulated K flux and for the anesthetic preconditioning-induced cardioprotection, [RefSeq, PubMed]; Slick and Slack are expressed at high levels auditory brainstem. Activation of these KNa channels allows temporal accuracy of firing to be increased at high frequencies of stimulation., [RefSeq, PubMed]; Sodium-activated and chloride-activated potassium channel. Produces rapidly activating outward rectifier K(+) currents (By similarity). Contributes to regulate neuronal excitability (PubMed:28943756)., [UniProtKB, PubMed, UniProtKB]; This study showed that the Intense Slick channel immunoreactivity was observed in processes, varicosities, and neuronal cell bodies of the olfactory bulb, granular zones of cortical regions, hippocampus, amygdala, lateral septal nuclei, certain hypothalamic and midbrain nuclei, and several regions of the brainstem., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, 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"go_biological_process": "GO:0006813 potassium ion transport;GO:0071805 potassium ion transmembrane transport;GO:0097623 potassium ion export across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "D3Z649-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PZQ8-1", "uniprot_id": [ { "id": "E9PZQ8_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PZQ8", "type": "external" } ], "mass": 51880.0, "length": 461, "protein_name": "Zinc finger protein 764 like 1", "gene_name": "Zfp764l1", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC101604", "refseq_ac": [ { "id": "NP_932128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932128", "type": "external" } ], "gene_names_uniprotkb": "Zfp764l1; E430018J23Rik", "gene_names_refseq": "E430018J23Rik; Zfp764l1", "protein_names_uniprotkb": "Zinc finger protein 764 like 1", "protein_names_refseq": "uncharacterized protein LOC101604", "tax_id": 10090, "disease": "", "pathway": " (mmu:101604); (R-MMU-212436)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, 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"E9PZQ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0N4SVQ0-1", "uniprot_id": [ { "id": "A0A0N4SVQ0_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0N4SVQ0", "type": "external" } ], "mass": 43787.0, "length": 395, "protein_name": "Serine protease 47", "gene_name": "Prss47", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prss47", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine protease 47", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:218304)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, 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"disease": "", "pathway": " (mmu:100039890)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2BI72-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z286-1", "uniprot_id": [ { "id": "D3Z286_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z286", "type": "external" } ], "mass": 49401.0, "length": 447, "protein_name": "Transmembrane protein with metallophosphoesterase domain", "gene_name": "Tmppe", "organism": "Mouse", "refseq_name": "transmembrane protein with metallophosphoesterase domain", "refseq_ac": [ { "id": "NP_001186931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186931", "type": "external" } ], "gene_names_uniprotkb": "Tmppe; Glb1", "gene_names_refseq": "Tmppe", "protein_names_uniprotkb": "Transmembrane protein with metallophosphoesterase domain", "protein_names_refseq": "transmembrane protein with metallophosphoesterase domain", "tax_id": 10090, "disease": "", "pathway": " (mmu:100504715)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z286-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z7A5-1", "uniprot_id": 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Glyatl3; Gm5683", "protein_names_uniprotkb": "Glycine-N-acyltransferase-like protein 3; 2.3.1.13; Acyl-CoA:glycine-N-acyltransferase-like protein 3", "protein_names_refseq": "acyl-CoA:glycine-N-acyltransferase-like protein 3; glycine N-acyltransferase-like protein 3; glycine-N-acyltransferase-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:435528); (R-MMU-159424); (R-MMU-177128); (R-MMU-177135); (R-MMU-9749641)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "27016726", "class_list": "", "function": "Catalyzes the conjugation of long-chain fatty acyl-CoA thioester and glycine to produce long-chain N-(fatty acyl)glycine, an intermediate in the primary fatty acid amide biosynthetic pathway., [UniProtKB, PubMed]; Knockdown of GLYATL3 in the mouse neuroblastoma cells resulted in a decrease in the levels of the N-acylglycines and the primary fatty acid amides., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.13", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.71", "type": "external" } ], "go_molecular_function": "GO:0047961 glycine N-acyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q5L8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q7L1-1", "uniprot_id": [ { "id": "E9Q7L1_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q7L1", "type": "external" } ], "mass": 171620.0, "length": 1524, "protein_name": "URB2 ribosome biogenesis 2 homolog (S. cerevisiae)", "gene_name": "Urb2", "organism": "Mouse", "refseq_name": "unhealthy ribosome biogenesis protein 2 homolog", "refseq_ac": [ { "id": "NP_001025047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025047", "type": "external" } ], "gene_names_uniprotkb": "Urb2", "gene_names_refseq": "Urb2; mKIAA0133", "protein_names_uniprotkb": "URB2 ribosome biogenesis 2 homolog (S. cerevisiae)", "protein_names_refseq": "unhealthy ribosome biogenesis protein 2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:382038)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25605945", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0030496 midbody", "go_biological_process": "GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E9Q7L1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6ZIS7-1", "uniprot_id": [ { "id": "F6ZIS7_MOUSE", "url": "https://www.uniprot.org/uniprot/F6ZIS7", "type": "external" } ], "mass": 32095.0, "length": 283, "protein_name": "Retinoic acid receptor responder (tazarotene induced) 1", "gene_name": "Rarres1", "organism": "Mouse", "refseq_name": "retinoic acid receptor responder protein 1 precursor", "refseq_ac": [ { "id": "NP_001158235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158235", "type": "external" } ], "gene_names_uniprotkb": "Rarres1", "gene_names_refseq": "5430417P09Rik; Rarres1", "protein_names_uniprotkb": "Retinoic acid receptor responder (tazarotene induced) 1", "protein_names_refseq": "retinoic acid receptor responder protein 1 precursor", "tax_id": 10090, "disease": "follicular lymphoma (Disease Ontology:DOID:0050873)", "pathway": " (mmu:109222)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;31905805;32634130;34147551;35541897;38697478", "class_list": "", "function": "Loss of RARRES1 function Promotes Follicular Lymphomagenesis and Inhibits B cell Differentiation in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Podocyte-derived soluble RARRES1 drives kidney disease progression through direct podocyte and proximal tubular injury., [RefSeq, PubMed]; RARRES1 and 2 may have different expression and roles in human and rodent placentas, thereby underlining immanent limitations of comparative interspecies placentology. Publication Status: Online-Only, [RefSeq, PubMed]; Retinoic acid receptor responder1 promotes development of glomerular diseases via the Nuclear Factor-kappaB signaling pathway., [RefSeq, PubMed]; Soluble RARRES1 induces podocyte apoptosis to promote glomerular disease progression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "F6ZIS7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F8VPT3-1", "uniprot_id": [ { "id": "F8VPT3_MOUSE", "url": "https://www.uniprot.org/uniprot/F8VPT3", "type": "external" } ], "mass": 217802.0, "length": 1931, "protein_name": "Lactase/phlorizin hydrolase", "gene_name": "Lct", "organism": "Mouse", "refseq_name": "lactase/phlorizin hydrolase preproprotein", "refseq_ac": [ { "id": "NP_001074547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074547", "type": "external" } ], "gene_names_uniprotkb": "Lct", "gene_names_refseq": "Gm100; LAC; LPH; Lct; Lphl", "protein_names_uniprotkb": "Lactase/phlorizin hydrolase; 3.2.1.108; 3.2.1.62; Lactase/glycosylceramidase", "protein_names_refseq": "lactase-phlorizin hydrolase; lactase/phlorizin hydrolase preproprotein", "tax_id": 10090, "disease": "colitis (Disease Ontology:DOID:0060180); congenital lactase deficiency (Disease Ontology:DOID:0111646); diarrhea (Disease Ontology:DOID:13250); kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:226413); (R-MMU-189085)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "16629594;17272516;18211959;21750661;28011936", "class_list": "glycogene;glycosylhydrolase", "function": "Broad specificity glycosidase of the intestinal brush border membrane that hydrolyzes lactose, the main sugar in mammalian milk, to produce D-glucose and D-galactose. The mature protein is composed of two domains that catalyze the hydrolysis of beta-glucopyranosides and beta-galactopyranosides, with a preference for hydrophilic aglycones (in lactose and cellobiose) for one domain and hydrophobic aglycones (in phlorizin and glycosylceramides) for the other., [UniProtKB, UniProtKB]; Data found transport defects of the intestinal brush border hydrolases lactase-phlorizin hydrolase (LPH) in galectin-3-null mutant mice, showing that it directly interact with galectin-3 and transit through non-raft-dependent apical transport platforms., [RefSeq, PubMed]; Inactivation of Gata4 had no effect on LPH gene expression, whereas inactivation of Hnf1alpha resulted in a 50% reduction in LPH gene expression during either cytodifferentiation or suckling., [RefSeq, PubMed]; Lactase gene promoter fragments mediate differential spatial and temporal expression patterns in transgenic mice., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 121, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.108", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.108", "type": "external" }, { "id": "3.2.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.62", "type": "external" } ], "go_molecular_function": "GO:0004348 glucosylceramidase activity;GO:0008422 beta-glucosidase activity;GO:0042803 protein homodimerization activity;GO:0016740 transferase activity;GO:0004336 galactosylceramidase activity", "go_cellular_component": "GO:0005903 brush border;GO:0098591 external side of apical plasma membrane", "go_biological_process": "GO:0007584 response to nutrient;GO:0010288 response to lead ion;GO:0045471 response to ethanol;GO:0001666 response to hypoxia;GO:0010040 response to iron(II) ion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "F8VPT3-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3QN49-1", "uniprot_id": [ { "id": "J3QN49_MOUSE", "url": "https://www.uniprot.org/uniprot/J3QN49", "type": "external" } ], "mass": 9851.0, "length": 87, "protein_name": "Exocrine gland secreted peptide 3", "gene_name": "Esp3", "organism": "Mouse", "refseq_name": "exocrine gland-secreting peptide 3", "refseq_ac": [ { "id": "NP_001238845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001238845", "type": "external" } ], "gene_names_uniprotkb": "Esp3", "gene_names_refseq": "Esp3; Gm21945", "protein_names_uniprotkb": "Exocrine gland secreted peptide 3", "protein_names_refseq": "exocrine gland-secreting peptide 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:100126766)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005186 pheromone 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0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JDP5-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JEY2-1", "uniprot_id": [ { "id": "A0A0G2JEY2_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0G2JEY2", "type": "external" } ], "mass": 2306.0, "length": 21, "protein_name": "T cell receptor alpha joining 49", "gene_name": "Traj49", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Traj49", "gene_names_refseq": "", "protein_names_uniprotkb": "T cell receptor alpha joining 49", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JEY2-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YYZ1-1", "uniprot_id": [ { "id": "D3YYZ1_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YYZ1", "type": "external" } ], "mass": 23634.0, "length": 218, "protein_name": "Low density lipoprotein receptor class A domain containing 1", "gene_name": "Ldlrad1", "organism": "Mouse", "refseq_name": "low-density lipoprotein receptor class A domain-containing protein 1", "refseq_ac": [ { "id": "NP_001074741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074741", "type": "external" } ], "gene_names_uniprotkb": "Ldlrad1", "gene_names_refseq": "Ldlrad1", "protein_names_uniprotkb": "Low density lipoprotein receptor class A domain containing 1", "protein_names_refseq": "low-density lipoprotein receptor class A domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:546840)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3YYZ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z167-1", "uniprot_id": [ { "id": "D3Z167_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z167", "type": "external" } ], "mass": 6465.0, "length": 63, "protein_name": "Predicted gene 16253", "gene_name": "Gm16253", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm16253", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene 16253", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z167-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0J9YVH3-1", "uniprot_id": [ { "id": "A0A0J9YVH3_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0J9YVH3", "type": "external" } ], "mass": 57835.0, "length": 498, "protein_name": "Expressed sequence AU041133", "gene_name": "AU041133", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC216177", "refseq_ac": [ { "id": "NP_001156536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156536", "type": "external" } ], "gene_names_uniprotkb": "AU041133", "gene_names_refseq": "AU041133", "protein_names_uniprotkb": "Expressed sequence AU041133", "protein_names_refseq": "uncharacterized protein LOC216177", "tax_id": 10090, "disease": "", "pathway": " (mmu:216177); (R-MMU-212436); (R-MMU-9843940)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0J9YVH3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A075B5S9-1", "uniprot_id": [ { "id": "A0A075B5S9_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A075B5S9", "type": "external" } ], "mass": 10934.0, "length": 98, "protein_name": "Immunoglobulin heavy variable 9-4", "gene_name": "Ighv9-4", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighv9-4", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy variable 9-4", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A075B5S9-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K285-1", "uniprot_id": [ { "id": "FCHO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K285", "type": "external" } ], "mass": 95122.0, "length": 873, "protein_name": "F-BAR domain only protein 1", "gene_name": "Fcho1", "organism": "Mouse", "refseq_name": "F-BAR domain only protein 1", "refseq_ac": [ { "id": "NP_082991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082991", "type": "external" } ], "gene_names_uniprotkb": "Fcho1", "gene_names_refseq": "3322402E17Rik; Fcho1", "protein_names_uniprotkb": "F-BAR domain only protein 1", "protein_names_refseq": "F-BAR domain only protein 1", "tax_id": 10090, "disease": "early-onset Parkinson's disease (Disease Ontology:DOID:0060894); primary immunodeficiency disease (Disease Ontology:DOID:612)", "pathway": " (mmu:74015); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;21762413;21952136;22484487;22872234;25605945;30084848;31219806;34428180;36210013;39627609", "class_list": "", "function": "Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation. Affects TCR clustering upon receptor triggering and modulates its internalization, playing a role in TCR-dependent T-cell activation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D3Z3Q5", "ec_number_list": [], "go_molecular_function": "GO:0035612 AP-2 adaptor complex binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0048268 clathrin coat assembly;GO:0072583 clathrin-dependent endocytosis;GO:0050870 positive regulation of T cell activation;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8K285-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ULA2-1", "uniprot_id": [ { "id": "FBW1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3ULA2", "type": "external" } ], "mass": 68923.0, "length": 605, "protein_name": "F-box/WD repeat-containing protein 1A", "gene_name": "Btrc", "organism": "Mouse", "refseq_name": "F-box/WD repeat-containing protein 1A isoform a", "refseq_ac": [ { "id": "NP_001032847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032847", "type": "external" } ], "gene_names_uniprotkb": "Btrc; Fbw1; Fbxw1; Fwd1; Kiaa4123", "gene_names_refseq": "Beta-Trcp1; Btrc; E3RS-IkappaB; E3RSIkappaB; FWD1; Fbw1a; HOS; SCF b-TRCP; Slimb; b-TrCP; beta-TrCP", "protein_names_uniprotkb": "F-box/WD repeat-containing protein 1A; Beta-TrCP protein E3RS-IkappaB; Beta-TrCP; Beta-transducin repeat-containing protein; E3RSIkappaB; F-box and WD repeats protein beta-TrCP; HOS; Ubiquitin ligase FWD1; mE3RS-IkappaB; pIkappaB-E3 receptor subunit", "protein_names_refseq": "F-box/WD repeat-containing protein 1A isoform a", "tax_id": 10090, "disease": "Menkes disease (Disease Ontology:DOID:1838)", "pathway": " (mmu:12234)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10097128;10531037;11735228;15917222;16371461;16611981;18782782;21750661;21911472;22037600;22872234;29593216;37287397;37584358;38184999;9859996;9990853", "class_list": "", "function": "Exosomal GPT2 derived from triple-negative breast cancer cells promotes metastasis by activating BTRC., [RefSeq, PubMed]; Novel targets of beta-TrCP cooperatively accelerate carbohydrate and fatty acid consumption., [RefSeq, PubMed]; Specific targeting of the NRF2/beta-TrCP axis promotes beneficial effects in NASH., [RefSeq, PubMed]; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10097128, PubMed:16371461, PubMed:16611981, PubMed:18782782, PubMed:21911472, PubMed:29593216, PubMed:9859996, PubMed:9990853). Recognizes and binds to phosphorylated target proteins (PubMed:10097128, PubMed:16371461, PubMed:16611981, PubMed:18782782, PubMed:21911472, PubMed:9859996, PubMed:9990853). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (By similarity). SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PubMed:10097128, PubMed:9859996). Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' (PubMed:10097128, PubMed:9859996). The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation (By similarity). SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (By similarity). SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (PubMed:21911472). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 (PubMed:18782782). May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase (By similarity). Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF (By similarity). SCF(BTRC) acts as a negative regulator of smoothened signaling by mediating ubiquitination of GLI2 and GLI3 in absence of smoothened, promoting their processing into transcription repressors (PubMed:16371461, PubMed:16611981). Mediates ubiquitination of REST, thereby leading to its proteasomal degradation (By similarity). SCF(BTRC) mediates the ubiquitination and subsequent proteasomal degradation of KLF4; thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216). SCF(BTRC) acts as a regulator of mTORC1 signaling pathway by catalyzing ubiquitination and subsequent proteasomal degradation of phosphorylated DEPTOR, TFE3 and MITF (By similarity). SCF(BTRC) directs 'Lys-48'-linked ubiquitination of UBR2 in the T-cell receptor signaling pathway (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0Q4;Q571K6;Q9QUI5;Q9R1G7;Q9Z159", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0061630 ubiquitin protein ligase activity;GO:0008013 beta-catenin binding;GO:0004842 ubiquitin-protein transferase activity;GO:0045309 protein phosphorylated amino acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006508 proteolysis;GO:0050852 T cell receptor signaling pathway;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q3ULA2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR14-1", "uniprot_id": [ { "id": "FANCL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR14", "type": "external" } ], "mass": 42527.0, "length": 375, "protein_name": "E3 ubiquitin-protein ligase FANCL", "gene_name": "Fancl", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase FANCL isoform 2", "refseq_ac": [ { "id": "NP_001264202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264202", "type": "external" } ], "gene_names_uniprotkb": "Fancl; Phf9; Pog", "gene_names_refseq": "2010322C19Rik; B230118H11Rik; Fancl; Phf9; Pog; gcd", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase FANCL; 2.3.2.27; Fanconi anemia group L protein homolog; Proliferation of germ cells protein; RING-type E3 ubiquitin transferase FANCL", "protein_names_refseq": "E3 ubiquitin-protein ligase FANCL isoform 2; E3 ubiquitin-protein ligase FANCL; PHD finger protein 9; RING-type E3 ubiquitin transferase FANCL; fanconi anemia group L protein homolog; germ cell deficient; proliferation of germ cells protein", "tax_id": 10090, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); Fanconi anemia complementation group L (Disease Ontology:DOID:0111082); Fanconi anemia (Disease Ontology:DOID:13636); 46 XX gonadal dysgenesis (Disease Ontology:DOID:14450)", "pathway": " (mmu:67030); (R-MMU-6783310); (R-MMU-9833482)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12417526;12574169;12606378;1297335;21229326;21750661;25428506;30084848;30779550", "class_list": "", "function": "This gene encodes the complementation group L subunit of the multimeric Fanconi anemia (FA) nuclear complex composed of proteins encoded by over ten Fanconi anemia complementation (FANC) group genes. The FA complex is necessary for protection against DNA damage. This gene product, an E3 ubiquitin ligase, catalyzes and is required for the monoubiquitination of the protein encoded by the Fanconi anemia, complementation group D2 gene, a critical step in the FA pathway (PMID: 12973351, 21229326). In mouse, mutations of this E3 ubiquitin ligase gene can lead to infertility in adult males and females, and a deletion of this gene can cause embryonic lethality in some genetic backgrounds. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]., [RefSeq]; Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth., [UniProtKB, PubMed, PubMed]; Using HeLa cells and lymphoblasts from Fanconi anemia patients, the authors characterize PHF9 (FANCL) as a ubiquitin ligase and show it is essential for FANCD2 monoubiquitination. The authors state that PHF9 is the human homolog of mouse Pog (Fancl)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TGY2;Q9D017", "ec_number_list": [ { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0006281 DNA repair;GO:0042127 regulation of cell population proliferation;GO:0006974 DNA damage response;GO:0036297 interstrand cross-link repair;GO:0006513 protein monoubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CR14-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTX7-1", "uniprot_id": [ { "id": "FHL5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTX7", "type": "external" } ], "mass": 32907.0, "length": 284, "protein_name": "Four and a half LIM domains protein 5", "gene_name": "Fhl5", "organism": "Mouse", "refseq_name": "four and a half LIM domains protein 5", "refseq_ac": [ { "id": "NP_067293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067293", "type": "external" } ], "gene_names_uniprotkb": "Fhl5; Act", "gene_names_refseq": "1700027G07Rik; Act; Fhl5", "protein_names_uniprotkb": "Four and a half LIM domains protein 5; Activator of CREM in testis; Activator of cAMP-responsive element modulator in testis; FHL-5", "protein_names_refseq": "FHL-5; LIM-only protein ACT; activator of CREM in testis; activator of cAMP-responsive element modulator in testis; four and a half LIM domains protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:57756)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10086359;12493914;15247423;20488182", "class_list": "", "function": "ACT selectively associates with KIF17b, a kinesin highly expressed in male germ cells; The ACT-KIF17b interaction is restricted to specific stages of spermatogenesis and directly determines the intracellular localization of ACT, [RefSeq, PubMed]; May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner (By similarity)., [UniProtKB]; Results indicate that SPAG8 acts as a regulator of ACT and plays an important role in CREM-ACT-mediated gene transcription during spermatogenesis., [RefSeq, PubMed]; Results indicate that numerous postmeiotic genes under CREM (cAMP-responsive element modulator) control require the coactivator function of ACT (activator of CREM) in testis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0030018 Z disc", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9WTX7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TQF0-1", "uniprot_id": [ { "id": "FBX31_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TQF0", "type": "external" } ], "mass": 57191.0, "length": 507, "protein_name": "F-box only protein 31", "gene_name": "Fbxo31", "organism": "Mouse", "refseq_name": "F-box only protein 31 isoform 1", "refseq_ac": [ { "id": "NP_598526", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598526", "type": "external" } ], "gene_names_uniprotkb": "Fbxo31; MNCb-2609", "gene_names_refseq": "1110003O08Rik; 2310046N15Rik; Fbx14; Fbxo14; Fbxo31", "protein_names_uniprotkb": "F-box only protein 31", "protein_names_refseq": "F-box only protein 14; F-box only protein 31 isoform 1; F-box only protein 31", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 45 (Disease Ontology:DOID:0081209)", "pathway": " (mmu:76454); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "17242355;21183079;21750661;22124152;25428506;31219806;37611899", "class_list": "", "function": "Aberrantly High FBXO31 Impairs Oocyte Quality in Premature Ovarian Insufficiency. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-recognition component of the SCF(FBXO31) protein ligase complex, which specifically mediates the ubiquitination of proteins amidated at their C-terminus in response to oxidative stress, leading to their degradation by the proteasome (By similarity). FBXO31 specifically recognizes and binds C-terminal peptides bearing an amide: C-terminal amidation in response to oxidative stress takes place following protein fragmentation (By similarity). The SCF(FBXO31) also plays a role in G1 arrest following DNA damage by mediating ubiquitination of phosphorylated cyclin-D1 (CCND1), promoting its degradation by the proteasome, resulting in G1 arrest (By similarity). The SCF(FBXO31) complex is however not a major regulator of CCND1 stability during the G1/S transition (PubMed:22124152). In response to genotoxic stress, the SCF(FBXO31) complex directs ubiquitination and degradation of phosphorylated MDM2, thereby promoting p53/TP53-mediated DNA damage response (By similarity). SCF(FBXO31) complex is required for genomic integrity by catalyzing ubiquitination and degradation of cyclin-A (CCNA1 and/or CCNA2) during the G1 phase (By similarity). In response to genotoxic stress, the SCF(FBXO31) complex directs ubiquitination and degradation of phosphorylated FBXO46 and MAP2K6 (By similarity). SCF(FBXO31) complex promotes ubiquitination and degradation of CDT1 during the G2 phase to prevent re-replication (By similarity). The SCF(FBXO31) complex also mediates ubiquitination and degradation of DUSP6, OGT and PARD6A (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K1A7;Q9JJC4", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0043025 neuronal cell body;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0006974 DNA damage response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0034599 cellular response to oxidative stress;GO:0042770 signal transduction in response to DNA damage;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3TQF0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PXT9-1", "uniprot_id": [ { "id": "F170B_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PXT9", "type": "external" } ], "mass": 43766.0, "length": 378, "protein_name": "Protein FAM170B", "gene_name": "Fam170b", "organism": "Mouse", "refseq_name": "protein FAM170B", "refseq_ac": [ { "id": "NP_001157957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157957", "type": "external" } ], "gene_names_uniprotkb": "Fam170b", "gene_names_refseq": "4922501K12Rik; Fam170b", "protein_names_uniprotkb": "Protein FAM170B; Acrosome-related protein", "protein_names_refseq": "acrosome-related protein; protein FAM170B; putative protein FAM170B", "tax_id": 10090, "disease": "", "pathway": " (mmu:105511)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26179146;32588889;38250762", "class_list": "", "function": "Involvement of FAM170B-AS1, hsa-miR-1202, and hsa-miR-146a-5p in breast cancer., [RefSeq, PubMed]; Plays a role in fertilization through the acrosome reaction., [UniProtKB, PubMed]; The expression and function for the endogenous acrosomal protein FAM170B during spermiogenesis and fertilization, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001669 acrosomal vesicle;GO:0002081 outer acrosomal membrane", "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:0009566 fertilization;GO:0080154 regulation of fertilization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9PXT9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3USH1-1", "uniprot_id": [ { "id": "INSY2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3USH1", "type": "external" } ], "mass": 46222.0, "length": 422, "protein_name": "Inhibitory synaptic factor 2A", "gene_name": "Insyn2a", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Insyn2a; Fam196a; Insy2", "gene_names_refseq": "", "protein_names_uniprotkb": "Inhibitory synaptic factor 2A; InSyn2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:627214)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;27609886", "class_list": "", "function": "Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RY32", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0014069 postsynaptic density;GO:0099572 postsynaptic specialization", "go_biological_process": "GO:0060080 inhibitory postsynaptic potential;GO:0099565 chemical synaptic transmission, postsynaptic", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3USH1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQF2-1", "uniprot_id": [ { "id": "FBX10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQF2", "type": "external" } ], "mass": 104478.0, "length": 950, "protein_name": "F-box only protein 10", "gene_name": "Fbxo10", "organism": "Mouse", "refseq_name": "F-box only protein 10 isoform 2", "refseq_ac": [ { "id": "NP_001019313", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019313", "type": "external" } ], "gene_names_uniprotkb": "Fbxo10; Gm634", "gene_names_refseq": "FBX10; Fbxo10; Gm634", "protein_names_uniprotkb": "F-box only protein 10", "protein_names_refseq": "F-box only protein 10 isoform 2; F-box only protein 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:269529); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "21183079;21750661;31219806;32782141;33914737;36210013", "class_list": "", "function": "Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. Targets also the receptor for advanced glycation end products RAGE for ubiquitination and subsequent lysosomal degradation. Directly controls HGAL/GCSAM ubiquitination and degradation and thereby decreases BCR signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ANI6;Q6AXG0;Q7TQM0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006915 apoptotic process;GO:0016567 protein ubiquitination;GO:0042981 regulation of apoptotic process;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7TQF2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14234-1", "uniprot_id": [ { "id": "FGR_MOUSE", "url": "https://www.uniprot.org/uniprot/P14234", "type": "external" } ], "mass": 58867.0, "length": 517, "protein_name": "Tyrosine-protein kinase Fgr", "gene_name": "Fgr", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase Fgr", "refseq_ac": [ { "id": "NP_034338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034338", "type": "external" } ], "gene_names_uniprotkb": "Fgr", "gene_names_refseq": "Ali18; Fgr; Mhdaali18", "protein_names_uniprotkb": "Tyrosine-protein kinase Fgr; 2.7.10.2; Proto-oncogene c-Fgr; p55-Fgr", "protein_names_refseq": "Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog; p55-Fgr; proto-oncogene c-Fgr; proto-oncogene tyrosine-protein kinase Fgr; tyrosine-protein kinase Fgr", "tax_id": 10090, "disease": "intestinal cancer (Disease Ontology:DOID:10155); Goldenhar syndrome (Disease Ontology:DOID:2907); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:14191); (R-MMU-2029481); (R-MMU-432142); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 18, "publication_id_list": "10662797;11672534;15561106;16439675;16684964;19144319;19903482;21183079;21746961;2179817;26495903;2674853;32943786;33055425;34428180;8125254;8666673;9687507", "class_list": "", "function": "Fgr contributes to hemorrhage-induced thalamic pain by activating NF-kappaB/ERK1/2 pathways. Publication Status: Online-Only, [RefSeq, PubMed]; Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity., [RefSeq, PubMed]; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCER1G and FCGR2. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes (PubMed:11672534). Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages (PubMed:8666673, PubMed:9687507). Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation (PubMed:15561106). Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling (PubMed:21746961). Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (PubMed:16439675)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61404;Q8BGM0", "ec_number_list": [ { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" } ], "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0001784 phosphotyrosine residue binding;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007229 integrin-mediated signaling pathway;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0030154 cell differentiation;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P14234-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37889-1", "uniprot_id": [ { "id": "FBLN2_MOUSE", "url": "https://www.uniprot.org/uniprot/P37889", "type": "external" } ], "mass": 131834.0, "length": 1221, "protein_name": "Fibulin-2", "gene_name": "Fbln2", "organism": "Mouse", "refseq_name": "fibulin-2 isoform a precursor", "refseq_ac": [ { "id": "NP_032018", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032018", "type": "external" } ], "gene_names_uniprotkb": "Fbln2", "gene_names_refseq": "5730577E14Rik; FIBL-2; Fbln2", "protein_names_uniprotkb": "Fibulin-2; FIBL-2", "protein_names_refseq": "fibulin-2 isoform a precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:14115); (R-MMU-2129379)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10022829;10406956;11737251;21750661;36288343;37249292;37828378;38396702;8245130;8841408;8850569", "class_list": "", "function": "Fibulin-2: A potential regulator of immune dysfunction after bone trauma., [RefSeq, PubMed]; Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN., [UniProtKB, UniProtKB]; Lung Inflammatory Phenotype in Mice Deficient in Fibulin-2 and ADAMTS-12. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "G5E8B3;Q9WUI2", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050840 extracellular matrix binding;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0001527 microfibril;GO:0071953 elastic fiber", "go_biological_process": "GO:0010811 positive regulation of cell-substrate adhesion", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P37889-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66LM6-1", "uniprot_id": [ { "id": "F170A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q66LM6", "type": "external" } ], "mass": 37392.0, "length": 333, "protein_name": "Protein FAM170A", "gene_name": "Fam170a", "organism": "Mouse", "refseq_name": "protein FAM170A isoform 1", "refseq_ac": [ { "id": "NP_001004061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004061", "type": "external" } ], "gene_names_uniprotkb": "Fam170a; Gm93; Znfd", "gene_names_refseq": "Fam170a; Gm93; Znfd", "protein_names_uniprotkb": "Protein FAM170A; Zinc finger domain-containing protein; Zinc finger protein ZNFD", "protein_names_refseq": "family with sequence similarity 170, member B; protein FAM170A isoform 1; protein FAM170A; zinc finger domain-containing protein; zinc finger protein ZNFD", "tax_id": 10090, "disease": "", "pathway": " (mmu:225497)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21750661;22231842;32588889;39868537", "class_list": "", "function": "Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes (PubMed:22231842). Binds to heat shock promoter elements (HSE) (PubMed:22231842). Necessary for normal sperm head morphology, efficient spermiation, and sperm progressive motility (PubMed:32588889). Plays a crucial role in sperm chromatin remodeling by promoting the nuclear translocation and deubiquitinating activity of USP7 on histone H2A and H2B variants. This ensures the timely removal of core histones, proper expression and degradation of transition proteins, and efficient incorporation of protamines during spermiogenesis (PubMed:39868537)., [UniProtKB, PubMed, PubMed, PubMed]; Knockout of family with sequence similarity 170 member A (Fam170a) causes male subfertility, while Fam170b is dispensable in micedagger., [RefSeq, PubMed]; Suggest that ZNFD may probably participate in the development of mouse testis and function as a transcription activator in HSE-mediated gene expression and signaling pathways., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RW56;Q66LM7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0009566 fertilization;GO:0045893 positive regulation of DNA-templated transcription;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q66LM6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMI0-1", "uniprot_id": [ { "id": "FBX38_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMI0", "type": "external" } ], "mass": 133928.0, "length": 1194, "protein_name": "F-box only protein 38", "gene_name": "Fbxo38", "organism": "Mouse", "refseq_name": "F-box only protein 38 isoform 4", "refseq_ac": [ { "id": "NP_598897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598897", "type": "external" } ], "gene_names_uniprotkb": "Fbxo38", "gene_names_refseq": "6030410I24Rik; Fbxo38; Moka; SP329", "protein_names_uniprotkb": "F-box only protein 38; MoKA; Modulator of KLF7 activity", "protein_names_refseq": "F-box only protein 38 isoform 4; F-box only protein 38; F-box protein modulating KLF7 activity; modulator of KLF7 activity", "tax_id": 10090, "disease": "autosomal dominant distal hereditary motor neuronopathy 6 (Disease Ontology:DOID:0111210)", "pathway": " (mmu:107035)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;14729953;16990251;18250455;18299400;19224205;19892989;20173027;21183079;21750661;21952136;22872234;25428506;25428507;25605945;30084848;30487606;30899004;31219806;34203471;34428180;35820727;36210013;37938970;39266770", "class_list": "", "function": "FBXO38 is dispensable for PD-1 regulation., [RefSeq, PubMed]; FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation., [RefSeq, PubMed]; MoKA and KLF7 interact functionally to regulate gene expression during cell differentiation, [RefSeq, PubMed]; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (PubMed:14729953, PubMed:16990251)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTQ4;Q8C0H4", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002842 positive regulation of T cell mediated immune response to tumor cell;GO:0010976 positive regulation of neuron projection development;GO:0002250 adaptive immune response;GO:0070936 protein K48-linked ubiquitination;GO:0050870 positive regulation of T cell activation", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q8BMI0-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCB3-1", "uniprot_id": [ { "id": "GYS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCB3", "type": "external" } ], "mass": 80871.0, "length": 704, "protein_name": "Glycogen [starch] synthase, liver", "gene_name": "Gys2", "organism": "Mouse", "refseq_name": "glycogen [starch] synthase, liver isoform 1", "refseq_ac": [ { "id": "NP_663547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663547", "type": "external" } ], "gene_names_uniprotkb": "Gys2", "gene_names_refseq": "Gys2; LGS", "protein_names_uniprotkb": "Glycogen [starch] synthase, liver; 2.4.1.11; Glycogen synthase 2", "protein_names_refseq": "glycogen [starch] synthase, liver isoform 1; glycogen [starch] synthase, liver; glycogen synthase, liver", "tax_id": 10090, "disease": "glycogen storage disease (Disease Ontology:DOID:2747); Lafora disease (Disease Ontology:DOID:3534)", "pathway": " (mmu:232493)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14680475;15014073;17242355;17437057;18630941;20430893;21183079;21750661;24982189;25605945;30084848;34428180;36396934;37453647;38183795", "class_list": "glycogene;glycosyltransferase", "function": "Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan., [UniProtKB, PubMed]; Identification of BMAL1-Regulated circadian genes in mouse liver and their potential association with hepatocellular carcinoma: Gys2 and Upp2 as promising candidates., [RefSeq, PubMed]; Mouse enzyme is a novel target of peroxisome proliferator-activated receptor, which is in turn mediated by two response elements., [RefSeq, PubMed]; N6-methyladenosine modification governs liver glycogenesis by stabilizing the glycogen synthase 2 mRNA. Publication Status: Online-Only, [RefSeq, PubMed]; The endogenous glycogen synthase in extracts from mouse liver bound specifically to SAPK2b/p38b & was phosphorylated at residues Ser644, Ser652, Thr718 and Ser724., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 45, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UTY0", "ec_number_list": [ { "id": "2.4.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.11", "type": "external" } ], "go_molecular_function": "GO:0004373 alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity;GO:0005536 D-glucose binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005938 cell cortex;GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0005977 glycogen metabolic process;GO:0005978 glycogen biosynthetic process;GO:0009749 response to glucose", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8VCB3-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4VBD9-1", "uniprot_id": [ { "id": "GZF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4VBD9", "type": "external" } ], "mass": 79533.0, "length": 706, "protein_name": "GDNF-inducible zinc finger protein 1", "gene_name": "Gzf1", "organism": "Mouse", "refseq_name": "GDNF-inducible zinc finger protein 1", "refseq_ac": [ { "id": "NP_083262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083262", "type": "external" } ], "gene_names_uniprotkb": "Gzf1; Zfp336", "gene_names_refseq": "8430437G08Rik; Gzf1; Zfp336; mGZF1", "protein_names_uniprotkb": "GDNF-inducible zinc finger protein 1; Zinc finger protein 336", "protein_names_refseq": "GDNF-inducible zinc finger protein 1; zinc finger protein 336", "tax_id": 10090, "disease": "", "pathway": " (mmu:74533)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14522971;19429458;21183079;21750661;25428506;28475863", "class_list": "", "function": "Induction of GZF1 expression via the is required for renal branching morphogenesis Erratum:[J Biol Chem. 2004 Jan 23;279(4):3120], [RefSeq, PubMed]; Progesterone receptors and glucocorticoid receptors, but not estrogen receptors, up-regulate transcription from the GDNF-inducible zinc finger protein promoter, [RefSeq, PubMed]; Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGY0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0001658 branching involved in ureteric bud morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q4VBD9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0J9YU00-1", "uniprot_id": [ { "id": "A0A0J9YU00_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0J9YU00", "type": "external" } ], "mass": 55051.0, "length": 481, "protein_name": "PRAME like 33", "gene_name": "Pramel33", "organism": "Mouse", "refseq_name": "PRAME family member 8-like", "refseq_ac": [ { "id": "XP_006535359", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006535359", "type": "external" } ], "gene_names_uniprotkb": "Pramel33", "gene_names_refseq": "Pramel33", "protein_names_uniprotkb": "PRAME like 33", "protein_names_refseq": "PRAME family member 8-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:100040885)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045596 negative regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0J9YU00-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X972-1", "uniprot_id": [ { "id": "G3X972_MOUSE", "url": "https://www.uniprot.org/uniprot/G3X972", "type": "external" } ], "mass": 118581.0, "length": 1096, "protein_name": "SEC24 homolog C, COPII coat complex component", "gene_name": "Sec24c", "organism": "Mouse", "refseq_name": "protein transport protein Sec24C isoform 1", "refseq_ac": [ { "id": "NP_766184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766184", "type": "external" } ], "gene_names_uniprotkb": "Sec24c", "gene_names_refseq": "2610204K03Rik; Sec24c; mKIAA0079", "protein_names_uniprotkb": "SEC24 homolog C, COPII coat complex component", "protein_names_refseq": "Sec24 related gene family, member C; protein transport protein Sec24C isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:218811); (R-MMU-204005); (R-MMU-2132295); (R-MMU-5694530); (R-MMU-983170)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;21454670;21750661;24876386;25153642;28135057;28528544;29939162;34702932;39927985;40997131", "class_list": "", "function": "Murine SEC24D can substitute functionally for SEC24C during embryonic development. Publication Status: Online-Only, [RefSeq, PubMed]; The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C, [RefSeq, PubMed]; These data suggest that SEC24C is a major cargo adapter for COPII-dependent transport in postmitotic neurons in developing and adult brains and that its functions overlap at least partially with those of SEC24D in mammals., [RefSeq, PubMed]; Thus, SEC24C is required in early mammalian development but is dispensable in a number of tissues, likely as a result of compensation by other Sec24 paralogs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site;GO:0030127 COPII vesicle coat", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0001701 in utero embryonic development;GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "G3X972-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17182-1", "uniprot_id": [ { "id": "ENOA_MOUSE", "url": "https://www.uniprot.org/uniprot/P17182", "type": "external" } ], "mass": 47141.0, "length": 434, "protein_name": "Alpha-enolase", "gene_name": "Eno1", "organism": "Mouse", "refseq_name": "enolase 1B, retrotransposed", "refseq_ac": [ { "id": "NP_001020559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020559", "type": "external" } ], "gene_names_uniprotkb": "Eno1; Eno-1", "gene_names_refseq": "EG433182; Eno-1; Eno1b; Eno1; Gm5506; NNE", "protein_names_uniprotkb": "Alpha-enolase; 2-phospho-D-glycerate hydro-lyase; 4.2.1.11; Enolase 1; NNE; Non-neural enolase", "protein_names_refseq": "2-phospho-D-glycerate hydro-lyase; Alpha-enolase; Non-neural enolase; enolase 1, alpha non-neuron; enolase 1B, retrotransposed", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763)", "pathway": " (mmu:13806); (mmu:433182)", "pathway_count": 2, "publication_count": 30, "publication_id_list": "10.1101/2023.09.13.557529;11229603;16139798;18034455;21183079;21750661;22872234;23446454;2362815;23806337;25605945;26495903;26740625;30031227;30779550;31219806;33300544;33725478;34428180;35820727;36210013;36288343;37453647;37507081;37828378;39627609;39927985;40684658;8427861;9169614", "class_list": "", "function": "Enolase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis. Also involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production., [UniProtKB, UniProtKB]; This gene may represent an evolving pseudogene of the alpha-enolase (enolase 1, alpha non-neuron) gene, which has multiple pseudogenes. This gene has an intact open reading frame as well as strong transcriptional support. The length of encoded protein is conserved, compared to the original enolase 1 protein. The exact function of this gene is unknown. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q99KT7;Q9DCY7", "ec_number_list": [ { "id": "4.2.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.11", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003723 RNA binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0009986 cell surface", "go_biological_process": "GO:0010756 positive regulation of plasminogen activation;GO:0045933 positive regulation of muscle contraction;GO:2001171 positive regulation of ATP biosynthetic process;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P17182-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PYH6-1", "uniprot_id": [ { "id": "SET1A_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PYH6", "type": "external" } ], "mass": 186060.0, "length": 1716, "protein_name": "Histone-lysine N-methyltransferase SETD1A", "gene_name": "Setd1a", "organism": "Mouse", "refseq_name": "histone-lysine N-methyltransferase SETD1A", "refseq_ac": [ { "id": "NP_821172", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_821172", "type": "external" } ], "gene_names_uniprotkb": "Setd1a", "gene_names_refseq": "KMT2F; Nsccn1; Setd1a; mKIAA0339; mNSC1", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SETD1A; 2.1.1.364; SET domain-containing protein 1A", "protein_names_refseq": "SET domain-containing protein 1A; histone-lysine N-methyltransferase SETD1A; non-selective cation channel 1", "tax_id": 10090, "disease": "neurodevelopmental disorder with speech impairment and dysmorphic facies (Disease Ontology:DOID:0070417); early-onset epilepsy 2 (Disease Ontology:DOID:0070471); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:233904); (R-MMU-3214841); (R-MMU-8936459); (R-MMU-9772755)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "16476528;21750661;24550110;29490266;31197650;31599954;34678516;34887587;35820727;38971831;39141687;40885482;40997131", "class_list": "", "function": "Epigenetic maintenance of adult neural stem cell quiescence in the mouse hippocampus via Setd1a. Publication Status: Online-Only, [RefSeq, PubMed]; Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (By similarity). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (PubMed:24550110, PubMed:29490266, PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation. Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (By similarity). Has RNA binding activity towards transcripts involved in RNA processing and the DNA damage response (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; MNSC1 lacks protein-coding capacity, [RefSeq, PubMed]; Sex-dependent effects of Setd1a haploinsufficiency on development and adult behaviour. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.370", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.370", "type": "external" }, { "id": "2.1.1.371", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.371", "type": "external" }, { "id": "2.1.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.85", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0008013 beta-catenin binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0042800 histone H3K4 methyltransferase activity;GO:0140945 histone H3K4 monomethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0000785 chromatin;GO:0035097 histone methyltransferase complex", "go_biological_process": "GO:2000648 positive regulation of stem cell proliferation;GO:0010628 positive regulation of gene expression;GO:0006974 DNA damage response;GO:0007420 brain development;GO:1902036 regulation of hematopoietic stem cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "E9PYH6-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q1A5-1", "uniprot_id": [ { "id": "E9Q1A5_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q1A5", "type": "external" } ], "mass": 63562.0, "length": 584, "protein_name": "Zinc finger protein 384", "gene_name": "Zfp384", "organism": "Mouse", "refseq_name": "zinc finger protein 384 isoform 1", "refseq_ac": [ { "id": "NP_780766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780766", "type": "external" } ], "gene_names_uniprotkb": "Zfp384", "gene_names_refseq": "C130073D16Rik; Ciz; NP; Nmp4; Zfp384", "protein_names_uniprotkb": "Zinc finger protein 384; Nuclear matrix transcription factor 4", "protein_names_refseq": "nuclear matrix protein 4; zinc finger protein 384 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:269800)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12052465;15189450;15669012;15716059;21750661;30779550;32152414;34887587;36321253;40997131", "class_list": "", "function": "Conditional Loss of Nmp4 in Mesenchymal Stem Progenitor Cells Enhances PTH-Induced Bone Formation., [RefSeq, PubMed]; Impaired spermatogenesis and male infertility occurred in Nmp4-disrupted mice., [RefSeq, PubMed]; Localization in the cytoplasm of osteoblasts, [RefSeq, PubMed]; NMP4 regulates the innate immune response to influenza A virus infection., [RefSeq, PubMed]; Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Transformation of 3T3 fibroblasts by CIZ/NMP4 fusions is dependent on DNA-binding and might involve transactivation of CIZ target genes, [RefSeq, PubMed]; Two adjacent promoters of Nmp4 P(1) [-2521 nucleotide (nt)/-597 nt] and P(2) (-2521 nt/+1 nt) initiate transcription of alternative first exons (U(1) and U(2))., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0017124 SH3 domain binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005925 focal adhesion", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006913 nucleocytoplasmic transport;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050714 positive regulation of protein secretion", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "E9Q1A5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIM3-1", "uniprot_id": [ { "id": "ER6L2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIM3", "type": "external" } ], "mass": 173873.0, "length": 1537, "protein_name": "DNA excision repair protein ERCC-6-like 2", "gene_name": "Ercc6l2", "organism": "Mouse", "refseq_name": "DNA excision repair protein ERCC-6-like 2 isoform 1", "refseq_ac": [ { "id": "NP_001013626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013626", "type": "external" } ], "gene_names_uniprotkb": "Ercc6l2; 0610007P08Rik; Rad26l", "gene_names_refseq": "0610007P08Rik; 1700019D06Rik; 9330134C04Rik; Ercc6l2; Rad26l; Sr278", "protein_names_uniprotkb": "DNA excision repair protein ERCC-6-like 2; 3.6.4.-; DNA repair and recombination protein RAD26-like", "protein_names_refseq": "DNA excision repair protein ERCC-6-like 2 isoform 1; DNA excision repair protein ERCC-6-like 2; DNA repair and recombination protein RAD26-like; putative repair and recombination helicase RAD26L; stretch responsive protein 278", "tax_id": 10090, "disease": "", "pathway": " (mmu:76251)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21183079;21750661;30084848;31219806;32355287;34428180;35820727", "class_list": "", "function": "ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells., [RefSeq, PubMed]; Promotes double-strand break (DSB) end-joining and facilitates programmed recombination by controlling how DNA ends are joined in a spatially oriented manner during repair (PubMed:32355287). Also plays a role in DNA repair by restricting DNA end resection in double strand break (DSB) repair. Facilitates replication of complex DNA regions and regulates the maintenance of chromatin structure (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q4J6;Q6DI94;Q8BIV4;Q8BM40;Q8K267;Q8R2Z6;Q9DA70;Q9DD01", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0019901 protein kinase binding;GO:0004386 helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome", "go_biological_process": "GO:0097680 double-strand break repair via classical nonhomologous end joining;GO:0006974 DNA damage response;GO:0034614 cellular response to reactive oxygen species;GO:0036297 interstrand cross-link repair", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JIM3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X964-1", "uniprot_id": [ { "id": "G3X964_MOUSE", "url": "https://www.uniprot.org/uniprot/G3X964", "type": "external" } ], "mass": 80282.0, "length": 669, "protein_name": "RIKEN cDNA 2610008E11 gene", "gene_name": "2610008E11Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC72128 isoform 1", "refseq_ac": [ { "id": "NP_001004362", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004362", "type": "external" } ], "gene_names_uniprotkb": "2610008E11Rik", "gene_names_refseq": "2610008E11Rik", "protein_names_uniprotkb": "RIKEN cDNA 2610008E11 gene", "protein_names_refseq": "uncharacterized protein LOC72128 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72128)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3X964-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1S3-1", "uniprot_id": [ { "id": "GRP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1S3", "type": "external" } ], "mass": 90304.0, "length": 795, "protein_name": "RAS guanyl-releasing protein 1", "gene_name": "Rasgrp1", "organism": "Mouse", "refseq_name": "RAS guanyl-releasing protein 1", "refseq_ac": [ { "id": "NP_035376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035376", "type": "external" } ], "gene_names_uniprotkb": "Rasgrp1; Rasgrp", "gene_names_refseq": "Rasgrp1; Rasgrp; calDAG-GEFII", "protein_names_uniprotkb": "RAS guanyl-releasing protein 1; CalDAG-GEFII; Calcium and DAG-regulated guanine nucleotide exchange factor II; Ras guanyl-releasing protein", "protein_names_refseq": "RAS guanyl-releasing protein 1; calcium and DAG-regulated guanine nucleotide exchange factor II", "tax_id": 10090, "disease": "immunodeficiency 64 (Disease Ontology:DOID:0111980); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:19419); (R-MMU-1169092); (R-MMU-354192); (R-MMU-392517); (R-MMU-5673001)", "pathway_count": 5, "publication_count": 25, "publication_id_list": "10087292;11017103;12433368;12538669;12845332;12932358;14532295;14970203;15829980;16301621;16849453;17190838;17210708;17523924;17567957;17675473;21750661;22116551;30084848;34428180;35820727;36385095;37566514;38419500;9819387", "class_list": "", "function": "Cutting Edge: Induced Loss of Rasgrp1 in Peripheral CD4+ T Cells of Conditional Rasgrp1-Deficient Mice Reveals an Essential Role for Rasgrp1 in TCR/CD28-Induced Ras-MAPK Signaling., [RefSeq, PubMed]; Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (By similarity). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (PubMed:17190838). May also function in differentiation of other cell types. Proto-oncogene, which promotes T-cell lymphomagenesis when its expression is deregulated (PubMed:15829980, PubMed:17210708)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; In addition to driving the CD8 double-negative to double-positive transition, increased expression of RasGRP1 selectively increases CD8 single-positive thymocyte numbers and enhances their responsiveness to T cell receptor signaling., [RefSeq, PubMed]; RASGRP1 targeted by H3K27me3 regulates myoblast proliferation and differentiation in mice and pigs., [RefSeq, PubMed]; RasGRP1 promotes the acute inflammatory response and restricts inflammation-associated cancer cell growth. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3URH0;Q3V401;Q8BQP6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031210 phosphatidylcholine binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0046579 positive regulation of Ras protein signal transduction;GO:0001934 positive regulation of protein phosphorylation;GO:0030154 cell differentiation;GO:0002437 inflammatory response to antigenic stimulus", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q9Z1S3-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61979-1", "uniprot_id": [ { "id": "HNRPK_MOUSE", "url": "https://www.uniprot.org/uniprot/P61979", "type": "external" } ], "mass": 50976.0, "length": 463, "protein_name": "Heterogeneous nuclear ribonucleoprotein K", "gene_name": "Hnrnpk", "organism": "Mouse", "refseq_name": "heterogeneous nuclear ribonucleoprotein K isoform 1", "refseq_ac": [ { "id": "NP_001288269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288269", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpk; Hnrpk", "gene_names_refseq": "Hnrnpk; Hnrpk; KBBP; NOVA", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein K; hnRNP K", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein K isoform 1", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); Raynaud disease (Disease Ontology:DOID:10300); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:15387); (R-MMU-4570464); (R-MMU-72163); (R-MMU-72203); (R-MMU-9770562)", "pathway_count": 5, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;16360036;18295448;18299400;19131326;19144319;20673990;21183079;21750661;22570411;23806337;24129315;26495903;31219806;33725478;34428180;35820727;35984892;37453647;38414246;39627609;40684658;8021272;8910362", "class_list": "", "function": "Hnrnpk protects against osteoarthritis through targeting WWC1 mRNA and inhibiting Hippo signaling pathway., [RefSeq, PubMed]; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; The protein encoded by this gene is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex, and is a poly-cytosine binding protein (PCBP). It is found in multiple subcellular compartments including the nucleus, cytoplasm and mitochondria. This gene product is thought to interact with RNA, DNA, and protein, and is involved in multiple cellular processes, including transcription, chromatin remodeling, DNA damage response, signal transduction, mRNA splicing, export, and translation. Multiple transcript variants and protein isoforms exist, with some isoforms containing a unique C-terminus. There are four pseudogenes of this gene, found on chromosomes 2, 3, 7 and 13. [provided by RefSeq, Aug 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q07244;Q15671;Q60577;Q8BGQ8;Q922Y7;Q96J62", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005938 cell cortex", "go_biological_process": "GO:0060816 random inactivation of X chromosome;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006397 mRNA processing;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P61979-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2ART2-1", "uniprot_id": [ { "id": "A2ART2_MOUSE", "url": "https://www.uniprot.org/uniprot/A2ART2", "type": "external" } ], "mass": 55916.0, "length": 485, "protein_name": "Zinc finger protein 966; Zinc finger protein 967; Zinc finger protein 968; Zinc finger protein 969", "gene_name": "Zfp967; Zfp968", "organism": "Mouse", "refseq_name": "KRAB box and zinc finger C2H2 type domain containing protein isoform 1", "refseq_ac": [ { "id": "NP_001170877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170877", "type": "external" } ], "gene_names_uniprotkb": "Zfp967; Zfp968; Zfp966; Zfp967; Zfp969", "gene_names_refseq": "Gm14431; Zfp967", "protein_names_uniprotkb": "Zinc finger protein 966; Zinc finger protein 967; Zinc finger protein 968; Zinc finger protein 969", "protein_names_refseq": "KRAB box and zinc finger C2H2 type domain containing protein isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:100043914); (mmu:100303732); (mmu:667962)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2ART2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XP8-1", "uniprot_id": [ { "id": "FA76B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80XP8", "type": "external" } ], "mass": 38556.0, "length": 339, "protein_name": "Protein FAM76B", "gene_name": "Fam76b", "organism": "Mouse", "refseq_name": "protein FAM76B isoform 1", "refseq_ac": [ { "id": "NP_789806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789806", "type": "external" } ], "gene_names_uniprotkb": "Fam76b", "gene_names_refseq": "2810485I05Rik; Fam76b", "protein_names_uniprotkb": "Protein FAM76B", "protein_names_refseq": "protein FAM76B isoform 1; protein FAM76B", "tax_id": 10090, "disease": "", "pathway": " (mmu:72826)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;34428180", "class_list": "", "function": "Negatively regulates the NF-kappa-B-mediated inflammatory pathway by preventing the translocation of HNRNPA2B1 from the nucleus to the cytoplasm. Inhibits the PI3K/Akt/NF-kappa-B pathway-mediated polarization of M1 macrophages by binding to and stabilizing PIK3CD mRNA, resulting in increased levels of PIK3CD protein and increased levels of phosphorylated downstream target AKT which leads to decreased NF-kappa-B signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMA6;Q80YR1;Q8CI69", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0016607 nuclear speck", "go_biological_process": "GO:0048255 mRNA stabilization;GO:0050728 negative regulation of inflammatory response;GO:0043031 negative regulation of macrophage activation;GO:0046826 negative regulation of protein export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80XP8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42859-1", "uniprot_id": [ { "id": "HD_MOUSE", "url": "https://www.uniprot.org/uniprot/P42859", "type": "external" } ], "mass": 344690.0, "length": 3119, "protein_name": "Huntingtin", "gene_name": "Htt", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Htt; Hdh; Hd", "gene_names_refseq": "", "protein_names_uniprotkb": "Huntingtin; HD protein homolog; Huntington disease protein homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (mmu:15194)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11035034;12456676;17242355;21183079;21750661;22872234;25605945;26198635;31219806;31599954;33300544;34203471;34428180;36210013;7647777;7759106;8009370;8162057", "class_list": "", "function": "May play a role in microtubule-mediated transport or vesicle function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Promotes the formation of autophagic vesicles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0031072 heat shock protein binding;GO:0044325 transmembrane transporter binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005769 early endosome", "go_biological_process": "GO:0048341 paraxial mesoderm formation;GO:1901526 positive regulation of mitophagy;GO:0006839 mitochondrial transport;GO:0007283 spermatogenesis;GO:0007611 learning or memory", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P42859-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70251-1", "uniprot_id": [ { "id": "EF1B_MOUSE", "url": "https://www.uniprot.org/uniprot/O70251", "type": "external" } ], "mass": 24694.0, "length": 225, "protein_name": "Elongation factor 1-beta", "gene_name": "Eef1b2; Eef1b", "organism": "Mouse", "refseq_name": "elongation factor 1-beta", "refseq_ac": [ { "id": "NP_061266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061266", "type": "external" } ], "gene_names_uniprotkb": "Eef1b2; Eef1b; Eef1b2", "gene_names_refseq": "2810017J07Rik; EF-1-beta; Eef1b2; Eef1b", "protein_names_uniprotkb": "Elongation factor 1-beta; EF-1-beta; eEF-1B alpha", "protein_names_refseq": "eEF-1B alpha; elongation factor 1-beta; eukaryotic translation elongation factor 1-beta homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:55949); (R-MMU-156842)", "pathway_count": 2, "publication_count": 24, "publication_id_list": "10870971;15240697;15345747;16075062;16479539;17242355;18630941;19131326;19144319;21183079;21750661;22872234;25605945;31219806;34203471;34428180;35820727;35984892;36210013;36288343;37453647;37507081;37828378;38878096", "class_list": "", "function": "Catalytic subunit of the guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) of the eukaryotic elongation factor 1 complex (eEF1). Stimulates the exchange of GDP for GTP on elongation factor 1A (eEF1A), probably by displacing GDP from the nucleotide binding pocket in eEF1A., [UniProtKB, UniProtKB]; EEF1B2 regulates bone marrow-derived mesenchymal stem cells bone-fat balance via Wnt/beta-catenin signaling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3THP5;Q5SUH1;Q8CHS1;Q99L22;Q9CZD4", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005853 eukaryotic translation elongation factor 1 complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0045471 response to ethanol;GO:0006414 translational elongation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "O70251-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17183-1", "uniprot_id": [ { "id": "ENOG_MOUSE", "url": "https://www.uniprot.org/uniprot/P17183", "type": "external" } ], "mass": 47297.0, "length": 434, "protein_name": "Gamma-enolase", "gene_name": "Eno2", "organism": "Mouse", "refseq_name": "gamma-enolase isoform 2", "refseq_ac": [ { "id": "NP_001289571", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289571", "type": "external" } ], "gene_names_uniprotkb": "Eno2; Eno-2", "gene_names_refseq": "D6Ertd375e; Eno-2; Eno2; NSE", "protein_names_uniprotkb": "Gamma-enolase; 2-phospho-D-glycerate hydro-lyase; 4.2.1.11; Enolase 2; NSE; Neural enolase; Neuron-specific enolase", "protein_names_refseq": "2-phospho-D-glycerate hydro-lyase; gamma-enolase isoform 2; gamma-enolase; neural enolase; neuron-specific enolase", "tax_id": 10090, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); migraine without aura (Disease Ontology:DOID:12783); toxic shock syndrome (Disease Ontology:DOID:14115); neuroendocrine carcinoma (Disease Ontology:DOID:1800); breast carcinoma (Disease Ontology:DOID:3459); brain disease (Disease Ontology:DOID:936)", "pathway": " (mmu:13807); (R-MMU-70171); (R-MMU-70263)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11229603;15648052;21750661;23446454;23576753;2362815;25605945;28011936;31219806;33725478;34428180;40684658;9445485", "class_list": "", "function": "Enolase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis (By similarity). Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.11", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0004634 phosphopyruvate hydratase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0009986 cell surface", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0032355 response to estradiol;GO:0006096 glycolytic process;GO:0061621 canonical glycolysis;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P17183-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08113-1", "uniprot_id": [ { "id": "ENPL_MOUSE", "url": "https://www.uniprot.org/uniprot/P08113", "type": "external" } ], "mass": 92476.0, "length": 802, "protein_name": "Endoplasmin", "gene_name": "Hsp90b1", "organism": "Mouse", "refseq_name": "endoplasmin precursor", "refseq_ac": [ { "id": "NP_035761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035761", "type": "external" } ], "gene_names_uniprotkb": "Hsp90b1; Grp94; Hspc4; Tra-1; Tra1", "gene_names_refseq": "ERp99; GRP94; Hsp90b1; TA-3; Targ2; Tra-1; Tra1; endoplasmin; gp96", "protein_names_uniprotkb": "Endoplasmin; 3.6.4.-; 94 kDa glucose-regulated protein; ERp99; Endoplasmic reticulum resident protein 99; GRP-94; Heat shock protein 90 kDa beta member 1; Polymorphic tumor rejection antigen 1; Tumor rejection antigen gp96", "protein_names_refseq": "94 kDa glucose-regulated protein; endoplasmic reticulum resident protein 99; endoplasmin precursor; heat shock protein 90 kDa beta member 1; polymorphic tumor rejection antigen 1; transforming growth factor alpha regulated gene 2; tumor rejection antigen (gp96) 1; tumor rejection antigen gp96", "tax_id": 10090, "disease": "male infertility due to globozoospermia (Disease Ontology:DOID:0112312); lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:22027); (R-MMU-1679131); (R-MMU-3000480); (R-MMU-381426); (R-MMU-6785807); (R-MMU-8957275)", "pathway_count": 6, "publication_count": 34, "publication_id_list": "10.1101/2023.09.13.557529;12475965;16931514;17525271;19349973;20865800;21093319;21750661;23572575;23806337;2438686;2768254;28011936;29187734;30059200;3036833;30899004;31219806;33300544;33725478;34428180;34887587;35820727;35984892;3612811;36210013;36288343;37453647;37507081;37828378;39627609;40684658;40885482;8179819", "class_list": "", "function": "ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:20865800, PubMed:23572575). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:20865800). Promotes folding and trafficking of TLR4 to the cell surface (By similarity). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 20, "disease_count": 2, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "P11427", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.98", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.112", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.112", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005790 smooth endoplasmic reticulum", "go_biological_process": "GO:0034123 positive regulation of toll-like receptor signaling pathway;GO:0043066 negative regulation of apoptotic process;GO:0072659 protein localization to plasma membrane;GO:0001666 response to hypoxia;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 6.5, "record_id": "P08113-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08046-1", "uniprot_id": [ { "id": "EGR1_MOUSE", "url": "https://www.uniprot.org/uniprot/P08046", "type": "external" } ], "mass": 56590.0, "length": 533, "protein_name": "Early growth response protein 1", "gene_name": "Egr1", "organism": "Mouse", "refseq_name": "early growth response protein 1", "refseq_ac": [ { "id": "NP_031939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031939", "type": "external" } ], "gene_names_uniprotkb": "Egr1; Egr-1; Krox-24", "gene_names_refseq": "A530045N19Rik; ETR103; Egr-1; Egr1; Krox-1; Krox-24; Krox24; NGF1-A; NGFI-A; NGFIA; TIS8; Zenk; Zfp-6; Zif268; egr", "protein_names_uniprotkb": "Early growth response protein 1; EGR-1; NGFI-A; Nerve growth factor-induced protein A; Transcription factor Zif268; Zinc finger protein Krox-24", "protein_names_refseq": "Krox-24 nuclear protein; early growth response protein 1; nerve growth factor-induced protein A; transcription factor Zif268; zinc finger protein Krox-24", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); myelodysplastic syndrome (Disease Ontology:DOID:0050908); silicosis (Disease Ontology:DOID:10325); Alzheimer's disease (Disease Ontology:DOID:10652); pulmonary sarcoidosis (Disease Ontology:DOID:13406); breast cancer (Disease Ontology:DOID:1612); aortic valve stenosis (Disease Ontology:DOID:1712); squamous cell carcinoma (Disease Ontology:DOID:1749); arteriosclerosis (Disease Ontology:DOID:2349); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); osteosarcoma (Disease Ontology:DOID:3347); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); pulmonary hypertension (Disease Ontology:DOID:6432); osteoarthritis (Disease Ontology:DOID:8398); lung disease (Disease Ontology:DOID:850); pulmonary emphysema (Disease Ontology:DOID:9675); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:13653)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "11100120;15265859;15958557;1740423;2028256;20485683;21606357;22517741;22645316;2511075;26471974;29138967;29187734;3127059;3133658;3141919;32782141;32848054;34678516;35822049;36852467;38861834;40885482;40997131;8336701;8662759;8703054;8939742", "class_list": "", "function": "Transcriptional regulator (PubMed:15958557, PubMed:8336701, PubMed:8703054). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (PubMed:15958557, PubMed:2028256, PubMed:8703054, PubMed:8939742). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia (PubMed:11100120, PubMed:15958557). Plays a role in the regulation of cell survival, proliferation and cell death (PubMed:15265859, PubMed:15958557). Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation (PubMed:15958557). Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy (PubMed:15265859). Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia (PubMed:11100120). Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (PubMed:8703054). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription (PubMed:26471974). Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (PubMed:29138967)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 24, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q61777", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0060086 circadian temperature homeostasis;GO:0044029 positive regulation of gene expression via chromosomal CpG island demethylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0002931 response to ischemia", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P08046-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61701-1", "uniprot_id": [ { "id": "ELAV4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61701", "type": "external" } ], "mass": 42368.0, "length": 385, "protein_name": "ELAV-like protein 4", "gene_name": "Elavl4", "organism": "Mouse", "refseq_name": "ELAV-like protein 4 isoform b", "refseq_ac": [ { "id": "NP_001033787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033787", "type": "external" } ], "gene_names_uniprotkb": "Elavl4; Hud", "gene_names_refseq": "Elavl4; Elav; Hud; PNEM", "protein_names_uniprotkb": "ELAV-like protein 4; Hu-antigen D; HuD; Paraneoplastic encephalomyelitis antigen HuD", "protein_names_refseq": "ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D); ELAV-like protein 4 isoform b; ELAV-like protein 4; HU-antigen D; RNA-binding protein HUD3; paraneoplastic encephalomyelitis antigen HuD", "tax_id": 10090, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); hypothyroidism (Disease Ontology:DOID:1459); status epilepticus (Disease Ontology:DOID:1824); learning disability (Disease Ontology:DOID:8927)", "pathway": " (mmu:15572)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;11573004;15086518;15519747;15764704;16554442;17035636;18218628;18493953;20064466;21183079;21288476;21389246;21750661;22387028;22895702;23383270;24599466;24857657;25692578;26305964;28111162;8535975;9096138;9524251", "class_list": "", "function": "RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (PubMed:15764704, PubMed:16554442, PubMed:17035636, PubMed:20064466, PubMed:22387028, PubMed:23383270, PubMed:26305964, PubMed:28111162). Plays a role in the regulation of mRNA stability, alternative splicing and translation (PubMed:15764704, PubMed:23383270, PubMed:26305964, PubMed:28111162). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (3'UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA (By similarity). Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function (PubMed:26305964). By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay (By similarity). Also binds to the polyadenylated (poly(A)) tail in the 3'UTR of mRNA, thereby increasing its affinity for mRNA binding (PubMed:20064466). Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms (PubMed:15764704, PubMed:16554442, PubMed:18218628, PubMed:23383270, PubMed:24599466, PubMed:25692578, PubMed:26305964, PubMed:28111162). Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells (PubMed:15764704). Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA (PubMed:26305964). Binds and stabilizes MSI1 mRNA in neural stem cells (PubMed:16554442). Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression (By similarity). Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization (By similarity). Plays a role in neurite outgrowth and in the establishment and maturation of dendritic arbors, thereby contributing to neocortical and hippocampal circuitry function (PubMed:24599466). Stabilizes GAP43 mRNA and protects it from decay during postembryonic development in the brain (PubMed:28111162). By promoting the stabilization of GAP43 mRNA, plays a role in NGF-mediated neurite outgrowth (By similarity). Binds to BDNF long 3'UTR mRNA, thereby leading to its stabilization and increased dendritic translation after activation of PKC (PubMed:23383270, PubMed:25692578). By increasing translation of BDNF after nerve injury, may contribute to nerve regeneration (PubMed:28111162). Acts as a stabilizing factor by binding to the 3'UTR of NOVA1 mRNA, thereby increasing its translation and enhancing its functional activity in neuron-specific splicing (PubMed:18218628). Stimulates translation of mRNA in a poly(A)- and cap-dependent manner, possibly by associating with the EIF4F cap-binding complex (PubMed:20064466). May also negatively regulate translation by binding to the 5'UTR of Ins2 mRNA, thereby repressing its translation (PubMed:22387028). Upon glucose stimulation, Ins2 mRNA is released from ELAVL4 and translational inhibition is abolished (PubMed:22387028). Also plays a role in the regulation of alternative splicing (PubMed:17035636). May regulate alternative splicing of CALCA pre-mRNA into Calcitonin and Calcitonin gene-related peptide 1 (CGRP) by competing with splicing regulator TIAR for binding to U-rich sequences of CALCA pre-mRNA (PubMed:17035636)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A9R6;A2A9R7;A2A9R8;A2A9S0;A2A9S1;A2A9S2;A2A9S3;O55010;Q6PHZ3;Q8BVA9", "ec_number_list": [], "go_molecular_function": "GO:0097158 pre-mRNA intronic pyrimidine-rich binding;GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding;GO:0035925 mRNA 3'-UTR AU-rich region binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0006396 RNA processing;GO:0006397 mRNA processing;GO:0007612 learning;GO:0007626 locomotory behavior;GO:0043488 regulation of mRNA stability", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q61701-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BG67-1", "uniprot_id": [ { "id": "EFR3A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BG67", "type": "external" } ], "mass": 92613.0, "length": 819, "protein_name": "Protein EFR3 homolog A", "gene_name": "Efr3a", "organism": "Mouse", "refseq_name": "protein EFR3 homolog A isoform 1", "refseq_ac": [ { "id": "NP_598527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598527", "type": "external" } ], "gene_names_uniprotkb": "Efr3a; Kiaa0143", "gene_names_refseq": "A130089M23Rik; C920006C10Rik; D030063F01Rik; Efr3a; mKIAA0143", "protein_names_uniprotkb": "Protein EFR3 homolog A; Protein EFR3-like", "protein_names_refseq": "protein EFR3 homolog A isoform 1; protein EFR3 homolog A", "tax_id": 10090, "disease": "", "pathway": " (mmu:76740)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "15363888;18299400;19144319;19224205;20173027;21183079;21750661;22872234;25380825;25428506;28193719;30084848;30779550;31219806;32152506;33300544;33649389;34203471;34428180;35820727", "class_list": "", "function": "A GENE encodes mouse homolog of KIAA0143 protein, one derived from a series of unidentified human genes. This gene termed mKIAA0143 shows differential expression of mRNA in the lateral superior olive between mice with hearing los and nornal mice., [RefSeq, PubMed]; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, EFR3A probably acts as the membrane-anchoring component. Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; That brain-specific deletion of Efr3a could promote adult hippocampal neurogenesis, presumably by upregulating the expression of BDNF and its receptor, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZQI4;Q8BXQ7;Q8C0Q0;Q922I2", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0001533 cornified envelope;GO:0098793 presynapse", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0098609 cell-cell adhesion;GO:0016082 synaptic vesicle priming", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q8BG67-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DTT3-1", "uniprot_id": [ { "id": "TASO2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5DTT3", "type": "external" } ], "mass": 264278.0, "length": 2382, "protein_name": "Protein TASOR 2", "gene_name": "Tasor2", "organism": "Mouse", "refseq_name": "protein TASOR 2 isoform 1", "refseq_ac": [ { "id": "NP_598824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598824", "type": "external" } ], "gene_names_uniprotkb": "Tasor2; Fam208b; Kiaa2006; Pap20", "gene_names_refseq": "Fam208b; Pap20; Tasor2; mKIAA2006", "protein_names_uniprotkb": "Protein TASOR 2; Peripheral benzodiazepine receptor-associated protein 20", "protein_names_refseq": "PBR associated protein; family with sequence similarity 208, member B; peripheral benzodiazepine receptor-associated protein 20; peripherial benzodiazepine receptor associated protein; protein FAM208B; protein TASOR 2 isoform 1; protein TASOR 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:105203)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11731621;21183079;21750661;21952136;22872234;34428180;35820727;36852467;40997131", "class_list": "", "function": "Core component of the HUSH2 complex, a multiprotein complex that mediates epigenetic repression of interferon-stimulated genes (By similarity). TASOR2 is recruited to interferon-stimulated genes by IRF2, leading to transcriptional silencing by the HUSH2 complex via a H3K9me3-independent mechanism (By similarity). Within the HUSH2 complex, TASOR2 acts as the central scaffold, which recruits MPHOSPH8 and PPHLN1 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O35330;Q0P5P9;Q3UUS0;Q5U5L9;Q6DI89;Q6ZQM5;Q91W76", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin;GO:0140286 HUSH2 complex", "go_biological_process": "GO:0045814 negative regulation of gene expression, epigenetic;GO:0032480 negative regulation of type I interferon production", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q5DTT3-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09127-1", "uniprot_id": [ { "id": "EPHA8_MOUSE", "url": "https://www.uniprot.org/uniprot/O09127", "type": "external" } ], "mass": 110705.0, "length": 1004, "protein_name": "Ephrin type-A receptor 8", "gene_name": "Epha8", "organism": "Mouse", "refseq_name": "ephrin type-A receptor 8 isoform 1 precursor", "refseq_ac": [ { "id": "NP_031965", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031965", "type": "external" } ], "gene_names_uniprotkb": "Epha8; Eek", "gene_names_refseq": "Eek; Epha8; Hek3; mKIAA1459", "protein_names_uniprotkb": "Ephrin type-A receptor 8; 2.7.10.1; EPH- and ELK-related kinase; Tyrosine-protein kinase receptor EEK", "protein_names_refseq": "EPH- and ELK-related kinase; Ephrin type-A receptor 8 precursor (Tyrosine-protein kinase receptor EEK) (EPH-and ELK-related kinase); ephrin type-A receptor 8 isoform 1 precursor; tyrosine-protein kinase receptor EEK", "tax_id": 10090, "disease": "", "pathway": " (mmu:13842); (R-MMU-2682334); (R-MMU-3928663); (R-MMU-3928665)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10498895;11416136;12681484;15782114;17875921;20100865;20496116;31599954;9053851;9214628", "class_list": "", "function": "Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A3KG07", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0005005 transmembrane-ephrin receptor activity;GO:0005003 ephrin receptor activity;GO:0005004 GPI-linked ephrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0031901 early endosome membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0033628 regulation of cell adhesion mediated by integrin;GO:0007155 cell adhesion;GO:0016322 neuron remodeling;GO:0030155 regulation of cell adhesion;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O09127-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97767-1", "uniprot_id": [ { "id": "EYA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97767", "type": "external" } ], "mass": 64324.0, "length": 591, "protein_name": "Protein phosphatase EYA1", "gene_name": "Eya1", "organism": "Mouse", "refseq_name": "protein phosphatase EYA1 isoform 3", "refseq_ac": [ { "id": "NP_001297388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297388", "type": "external" } ], "gene_names_uniprotkb": "Eya1", "gene_names_refseq": "Eya1; bor", "protein_names_uniprotkb": "Protein phosphatase EYA1; 3.1.3.16; 3.1.3.48; Eyes absent homolog 1", "protein_names_refseq": "eyes absent 1 homolog; eyes absent homolog 1; protein phosphatase EYA1 isoform 3; protein phosphatase EYA1", "tax_id": 10090, "disease": "branchiootic syndrome 1 (Disease Ontology:DOID:0061209); branchiootorenal syndrome 1 (Disease Ontology:DOID:0111423); branchiootorenal syndrome (Disease Ontology:DOID:14702); eye disease (Disease Ontology:DOID:5614); mitochondrial myopathy (Disease Ontology:DOID:699)", "pathway": " (mmu:14048); (R-MMU-5693565)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10072433;10471511;10490620;14628042;14628052;16024294;16990542;17098221;19234442;21750661;25428507;34428180;9006082;9020840;9887327", "class_list": "", "function": "Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:10490620). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (PubMed:14628042). Also has phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears (PubMed:10471511). Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2 (PubMed:17098221)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G5E864;O08818", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity;GO:0140793 histone H2AXY142 phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0048752 semicircular canal morphogenesis;GO:0007501 mesodermal cell fate specification;GO:0014706 striated muscle tissue development;GO:0006351 DNA-templated transcription;GO:0016925 protein sumoylation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P97767-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XG69-1", "uniprot_id": [ { "id": "F169A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5XG69", "type": "external" } ], "mass": 73240.0, "length": 665, "protein_name": "Soluble lamin-associated protein of 75 kDa", "gene_name": "Fam169a", "organism": "Mouse", "refseq_name": "soluble lamin-associated protein of 75 kDa", "refseq_ac": [ { "id": "NP_001093928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093928", "type": "external" } ], "gene_names_uniprotkb": "Fam169a; Kiaa0888", "gene_names_refseq": "B230112C05Rik; Fam169a; SLAP75", "protein_names_uniprotkb": "Soluble lamin-associated protein of 75 kDa; Protein FAM169A; SLAP75", "protein_names_refseq": "protein FAM169A; soluble lamin-associated protein of 75 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:320557); (R-MMU-9035034)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;17622165;21183079;25428506", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9Q0D7;Q69ZW7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031965 nuclear membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5XG69-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TH2-3", "uniprot_id": [ { "id": "ERBIN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TH2", "type": "external" } ], "mass": 157248.0, "length": 1402, "protein_name": "Erbin", "gene_name": "Erbin", "organism": "Mouse", "refseq_name": "erbin isoform 1", "refseq_ac": [ { "id": "NP_001005868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005868", "type": "external" } ], "gene_names_uniprotkb": "Erbin; Erbb2ip; Kiaa1225; Lap2", "gene_names_refseq": "1700028E05Rik; Erbb2ip; Erbin; mKIAA1225", "protein_names_uniprotkb": "Erbin; Densin-180-like protein; Erbb2-interacting protein; Protein LAP2", "protein_names_refseq": "densin-180-like protein; erbb2-interacting protein; erbin isoform 1; protein LAP2", "tax_id": 10090, "disease": "", "pathway": " (mmu:59079); (R-MMU-1227986); (R-MMU-8863795); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013408); (R-MMU-9013423); (R-MMU-9652282)", "pathway_count": 11, "publication_count": 28, "publication_id_list": "10.1101/2023.09.13.557529;10878805;16203728;17242355;17947660;18802028;19144319;19224205;20173027;21183079;21952136;22645316;25428506;28528544;30084848;30779550;31219806;32782141;32848054;34428180;35820727;36852467;37310569;37828378;38105228;39216682;40021952;40885482", "class_list": "", "function": "Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ERBB2 'Tyr-1248' receptor, it may contribute to stabilize this unphosphorylated state (By similarity). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). Acts as a mediator of keratinocyte differentiation by sequestering SHOC2 away from ERK-activating RAS complexes (By similarity)., [UniProtKB, UniProtKB, PubMed]; Erbin accelerates TFEB-mediated lysosome biogenesis and autophagy and alleviates sepsis-induced inflammatory responses and organ injuries. Publication Status: Online-Only, [RefSeq, PubMed]; Erbin alleviates sepsis-induced cardiomyopathy by inhibiting RIPK1-dependent necroptosis through activating PKA/CREB pathway., [RefSeq, PubMed]; Knockout of Erbin promotes pyroptosis via regulating NLRP3/caspase-1/Gasdermin D pathway in sepsis-induced acute kidney injury., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "E9QND6;Q8BQ14;Q8CE41;Q8K171;Q99JU3;Q9JI47", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0035556 intracellular signal transduction;GO:0006605 protein targeting;GO:0071638 negative regulation of monocyte chemotactic protein-1 production;GO:0071356 cellular response to tumor necrosis factor", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "Q80TH2-3", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMB0-1", "uniprot_id": [ { "id": "EMSY_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMB0", "type": "external" } ], "mass": 135291.0, "length": 1264, "protein_name": "BRCA2-interacting transcriptional repressor EMSY", "gene_name": "Emsy", "organism": "Mouse", "refseq_name": "BRCA2-interacting transcriptional repressor EMSY isoform 4", "refseq_ac": [ { "id": "NP_758484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758484", "type": "external" } ], "gene_names_uniprotkb": "Emsy", "gene_names_refseq": "2210018M11Rik; 2310016L09Rik; Emsy", "protein_names_uniprotkb": "BRCA2-interacting transcriptional repressor EMSY", "protein_names_refseq": "BRCA2-interacting transcriptional repressor EMSY isoform 4; BRCA2-interacting transcriptional repressor EMSY; protein EMSY", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841); allergic rhinitis (Disease Ontology:DOID:4481)", "pathway": " (mmu:233545)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;14651845;16452088;19458039;21183079;21606357;21750661;22315412;22517741;22645316;29237092;31219806;32782141;32848054;34428180;34678516;34963055;36084651;36852467;40997131", "class_list": "", "function": "Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY, [RefSeq, PubMed]; EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion., [RefSeq, PubMed]; Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (By similarity). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (By similarity). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 7, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 35, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 35, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 35, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 38, "binding_glycan_count": 0, "secondary_ac_list": "Q5FWK5;Q80XU1;Q8VDW9", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 6.2, "record_id": "Q8BMB0-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHI8-1", "uniprot_id": [ { "id": "EP400_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHI8", "type": "external" } ], "mass": 337180.0, "length": 3072, "protein_name": "E1A-binding protein p400", "gene_name": "Ep400", "organism": "Mouse", "refseq_name": "E1A-binding protein p400 isoform 1", "refseq_ac": [ { "id": "NP_083613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083613", "type": "external" } ], "gene_names_uniprotkb": "Ep400; Kiaa1498", "gene_names_refseq": "1700020J09Rik; Ep400; mDomino; mKIAA1498; p400", "protein_names_uniprotkb": "E1A-binding protein p400; 3.6.4.-; Domino homolog; mDomino; p400 kDa SWI2/SNF2-related protein", "protein_names_refseq": "E1A-binding protein p400 isoform 1; domino homolog; p400 kDa SWI2/SNF2-related protein", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); developmental disorder of mental health (Disease Ontology:DOID:0060037)", "pathway": " (mmu:75560); (R-MMU-2559584); (R-MMU-2559586)", "pathway_count": 3, "publication_count": 30, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;12653961;17242355;18758164;20173027;21183079;21606357;21750661;22517741;22645316;25428506;29237092;30084848;30779550;31219806;32782141;32848054;33649389;34428180;35820727;35822049;36210013;36852467;37024457;37922899;38861834;40021952;40885482;40997131", "class_list": "", "function": "Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity). Regulates transcriptional activity of ZNF42., [UniProtKB]; Global identification of SWI/SNF targets reveals compensation by EP400., [RefSeq, PubMed]; The Tip60/Ep400 chromatin remodeling complex impacts basic cellular functions in cranial neural crest-derived tissue during early orofacial development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 45, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 45, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 45, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 49, "binding_glycan_count": 0, "secondary_ac_list": "E9QKV1;Q3TPY1;Q5RKN8;Q80TC8;Q8BXI5;Q8BYW3;Q8C0P6;Q8CHI7;Q8VDF4;Q9DA54", "ec_number_list": [ { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:1990405 protein antigen binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000812 Swr1 complex;GO:0000786 nucleosome", "go_biological_process": "GO:0006281 DNA repair;GO:0007399 nervous system development;GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 7.9, "record_id": "Q8CHI8-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DB52-1", "uniprot_id": [ { "id": "PBIR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DB52", "type": "external" } ], "mass": 30270.0, "length": 284, "protein_name": "P2R1A-PPP2R2A-interacting phosphatase regulator 1", "gene_name": "Pabir1", "organism": "Mouse", "refseq_name": "P2R1A-PPP2R2A-interacting phosphatase regulator 1", "refseq_ac": [ { "id": "NP_080796", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080796", "type": "external" } ], "gene_names_uniprotkb": "Pabir1; Fam122a", "gene_names_refseq": "2410124L17Rik; 2900009I07Rik; Fam122a; Gm9849; Pabir1", "protein_names_uniprotkb": "P2R1A-PPP2R2A-interacting phosphatase regulator 1; PABIR family member 1", "protein_names_refseq": "P2R1A-PPP2R2A-interacting phosphatase regulator 1; PABIR family member 1; family with sequence similarity 122, member A; protein FAM122A", "tax_id": 10090, "disease": "", "pathway": " (mmu:68034)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;15345747;17242355;18630941;19131326;19144319;21183079;31219806;36715298", "class_list": "", "function": "Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (By similarity). Inhibits PP2A activity by blocking the substrate binding site on PPP2R2A and the active site of PPP2CA (By similarity). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (By similarity). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (By similarity)., [UniProtKB, UniProtKB]; FAM122A Is Required for Mesendodermal and Cardiac Differentiation of Embryonic Stem Cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TA50;Q9D078", "ec_number_list": [], "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity;GO:0051721 protein phosphatase 2A binding;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0044818 mitotic G2/M transition checkpoint", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9DB52-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R5C8-1", "uniprot_id": [ { "id": "ZMY11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R5C8", "type": "external" } ], "mass": 70838.0, "length": 602, "protein_name": "Zinc finger MYND domain-containing protein 11", "gene_name": "Zmynd11", "organism": "Mouse", "refseq_name": "zinc finger MYND domain-containing protein 11 isoform gamma", "refseq_ac": [ { "id": "NP_001186070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186070", "type": "external" } ], "gene_names_uniprotkb": "Zmynd11", "gene_names_refseq": "2210402G22Rik; BS69; Zmynd11", "protein_names_uniprotkb": "Zinc finger MYND domain-containing protein 11", "protein_names_refseq": "zinc finger MYND domain-containing protein 11 isoform gamma; zinc finger MYND domain-containing protein 11", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 30 (Disease Ontology:DOID:0070060); stomach cancer (Disease Ontology:DOID:10534)", "pathway": " (mmu:66505)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16565076;21750661;24590075;26845565", "class_list": "", "function": "BS69 has roles in gene repression and chromatin remodeling, [RefSeq, PubMed]; Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage (PubMed:24590075). Binds non-specifically to dsDNA (By similarity). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth (PubMed:24590075)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; This study identifies the BS69 C-terminal domains as an inhibitor of EBNA2. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G5E8Q2;Q8C155", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0003690 double-stranded DNA binding;GO:0140003 histone H3K36me3 reader activity;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0051607 defense response to virus;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R5C8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PYL8-1", "uniprot_id": [ { "id": "E9PYL8_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PYL8", "type": "external" } ], "mass": 28273.0, "length": 253, "protein_name": "Coiled-coil domain containing 192", "gene_name": "Ccdc192", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 192 isoform 1", "refseq_ac": [ { "id": "NP_083566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083566", "type": "external" } ], "gene_names_uniprotkb": "Ccdc192", "gene_names_refseq": "1700011I03Rik; 4930583I06Rik; Ccdc192", "protein_names_uniprotkb": "Coiled-coil domain containing 192", "protein_names_refseq": "coiled-coil domain-containing protein 192 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:75444)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PYL8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10649-1", "uniprot_id": [ { "id": "GSTM1_MOUSE", "url": "https://www.uniprot.org/uniprot/P10649", "type": "external" } ], "mass": 25970.0, "length": 218, "protein_name": "Glutathione S-transferase Mu 1", "gene_name": "Gstm1", "organism": "Mouse", "refseq_name": "glutathione S-transferase Mu 1 isoform 2", "refseq_ac": [ { "id": "NP_034488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034488", "type": "external" } ], "gene_names_uniprotkb": "Gstm1", "gene_names_refseq": "Gstb-1; Gstb1; Gstm1", "protein_names_uniprotkb": "Glutathione S-transferase Mu 1; 2.5.1.18; GST 1-1; GST class-mu 1; Glutathione S-transferase GT8.7; pmGT10", "protein_names_refseq": "GST 1-1; GST class-mu 1; glutathione S-transferase GT8.7; glutathione S-transferase Mu 1 isoform 2; pmGT10", "tax_id": 10090, "disease": "pterygium (Disease Ontology:DOID:0002116); Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); inflammatory bowel disease (Disease Ontology:DOID:0050589); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); medulloblastoma (Disease Ontology:DOID:0050902); myelodysplastic syndrome (Disease Ontology:DOID:0050908); stroke (Disease Ontology:DOID:0051061); autism spectrum disorder (Disease Ontology:DOID:0060041); pre-malignant neoplasm (Disease Ontology:DOID:0060071); drug allergy (Disease Ontology:DOID:0060500); alcohol-associated liver disease (Disease Ontology:DOID:0070658); hepatic veno-occlusive disease (Disease Ontology:DOID:0080177); colorectal carcinoma (Disease Ontology:DOID:0080199); erythema nodosum (Disease Ontology:DOID:0080750); graft-versus-host disease (Disease Ontology:DOID:0081267); osteonecrosis (Disease Ontology:DOID:10159); thalassemia (Disease Ontology:DOID:10241); prostate cancer (Disease Ontology:DOID:10283); asbestosis (Disease Ontology:DOID:10320); lymphoid leukemia (Disease Ontology:DOID:1037); esophageal atresia (Disease Ontology:DOID:10485); Hirschsprung's disease (Disease Ontology:DOID:10487); stomach cancer (Disease Ontology:DOID:10534); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); hypospadias (Disease Ontology:DOID:10892); urinary bladder cancer (Disease Ontology:DOID:11054); asphyxia neonatorum (Disease Ontology:DOID:11088); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); head and neck cancer (Disease Ontology:DOID:11934); allergic disease (Disease Ontology:DOID:1205); optic neuritis (Disease Ontology:DOID:1210); aplastic anemia (Disease Ontology:DOID:12449); autistic disorder (Disease Ontology:DOID:12849); uterine fibroid (Disease Ontology:DOID:13223); lung cancer (Disease Ontology:DOID:1324); angle-closure glaucoma (Disease Ontology:DOID:13550); cholestasis (Disease Ontology:DOID:13580); Fanconi anemia (Disease Ontology:DOID:13636); exfoliation syndrome (Disease Ontology:DOID:13641); Parkinson's disease (Disease Ontology:DOID:14330); aggressive periodontitis (Disease Ontology:DOID:1474); cystic fibrosis (Disease Ontology:DOID:1485); urticaria (Disease Ontology:DOID:1555); acute chest syndrome (Disease Ontology:DOID:1584); keratosis (Disease Ontology:DOID:161); breast cancer (Disease Ontology:DOID:1612); congenital heart disease (Disease Ontology:DOID:1682); malignant mesothelioma (Disease Ontology:DOID:1790); ovary epithelial cancer (Disease Ontology:DOID:2152); multiple sclerosis (Disease Ontology:DOID:2377); larynx cancer (Disease Ontology:DOID:2596); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); cervix carcinoma (Disease Ontology:DOID:2893); pulmonary tuberculosis (Disease Ontology:DOID:2957); adenocarcinoma (Disease Ontology:DOID:299); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gallbladder cancer (Disease Ontology:DOID:3121); porphyria cutanea tarda (Disease Ontology:DOID:3132); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); toxic encephalopathy (Disease Ontology:DOID:3602); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); Lynch syndrome (Disease Ontology:DOID:3883); gastritis (Disease Ontology:DOID:4029); systemic scleroderma (Disease Ontology:DOID:418); cervical cancer (Disease Ontology:DOID:4362); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); movement disease (Disease Ontology:DOID:480); small intestine adenocarcinoma (Disease Ontology:DOID:4906); esophagus adenocarcinoma (Disease Ontology:DOID:4914); cholangiocarcinoma (Disease Ontology:DOID:4947); esophageal cancer (Disease Ontology:DOID:5041); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); oral submucous fibrosis (Disease Ontology:DOID:5773); leukopenia (Disease Ontology:DOID:615); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); periodontitis (Disease Ontology:DOID:824); cataract (Disease Ontology:DOID:83); lung disease (Disease Ontology:DOID:850); Hodgkin's lymphoma (Disease Ontology:DOID:8567); infectious mononucleosis (Disease Ontology:DOID:8568); ulcerative colitis (Disease Ontology:DOID:8577); oral cavity cancer (Disease Ontology:DOID:8618); myeloid leukemia (Disease Ontology:DOID:8692); Crohn's disease (Disease Ontology:DOID:8778); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); polycythemia vera (Disease Ontology:DOID:8997); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); oral mucosa leukoplakia (Disease Ontology:DOID:9655); senile cataract (Disease Ontology:DOID:9669); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14862); (R-MMU-156590)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "21183079;21750661;2689439;30084848;31219806;33300544;3417659;34428180;35621716;36210013;36288343;37453647;37507081;3864155;39927985;6822548;8512323;8605288", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers., [UniProtKB, UniProtKB]; Gstm1/Gstt1 is essential for reducing cisplatin ototoxicity in CBA/CaJ mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 114, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AE90;Q58ET5", "ec_number_list": [ { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0043209 myelin sheath", "go_biological_process": "GO:0071466 cellular response to xenobiotic stimulus;GO:0042178 xenobiotic catabolic process;GO:0006693 prostaglandin metabolic process;GO:1901687 glutathione derivative biosynthetic process;GO:0051122 hepoxilin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P10649-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESZ8-1", "uniprot_id": [ { "id": "GTF2I_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ESZ8", "type": "external" } ], "mass": 112265.0, "length": 998, "protein_name": "General transcription factor II-I", "gene_name": "Gtf2i", "organism": "Mouse", "refseq_name": "general transcription factor II-I isoform 1", "refseq_ac": [ { "id": "NP_001074215", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074215", "type": "external" } ], "gene_names_uniprotkb": "Gtf2i; Bap135; Diws1t", "gene_names_refseq": "6030441I21Rik; BAP-135; Diws1t; Gtf2i; GtfII-I; Spin; TFII-I; WBSCR6", "protein_names_uniprotkb": "General transcription factor II-I; BAP-135; BTK-associated protein 135; Bruton tyrosine kinase-associated protein 135; GTFII-I; TFII-I", "protein_names_refseq": "BTK-associated protein 135; Bruton tyrosine kinase-associated protein 135; SRF-Phox1-interacting protein; Williams-Beuren syndrome chromosomal region 6 protein; general transcription factor II-I isoform 1", "tax_id": 10090, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (mmu:14886)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11313464;11827466;16738337;17600150;21183079;21750661;23806337;31219806;34428180;34887587;36175547;36756127;38450767;39627609;9521869", "class_list": "", "function": "Human thymoma-associated mutation of the GTF2I transcription factor impairs thymic epithelial progenitor differentiation in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box (By similarity). Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Neuronal deletion of Gtf2i results in developmental microglial alterations in a mouse model related to Williams syndrome., [RefSeq, PubMed]; Transcription factor TFII-I fine tunes innate properties of B lymphocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O54700;O55030;O55031;Q8VHD1;Q8VHD2;Q8VHD3;Q8VHD4;Q9CSB5;Q9D9K9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0051019 mitogen-activated protein kinase binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0043025 neuronal cell body;GO:0042995 cell projection", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0016525 negative regulation of angiogenesis;GO:0006366 transcription by RNA polymerase II;GO:0051481 negative regulation of cytosolic calcium ion concentration;GO:0014886 transition between slow and fast fiber", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9ESZ8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11499-1", "uniprot_id": [ { "id": "HS90B_MOUSE", "url": "https://www.uniprot.org/uniprot/P11499", "type": "external" } ], "mass": 83281.0, "length": 724, "protein_name": "Heat shock protein HSP 90-beta", "gene_name": "Hsp90ab1", "organism": "Mouse", "refseq_name": "heat shock protein HSP 90-beta", "refseq_ac": [ { "id": "NP_032328", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032328", "type": "external" } ], "gene_names_uniprotkb": "Hsp90ab1; Hsp84-1; Hsp84; Hspc3; Hspcb", "gene_names_refseq": "90kDa; Hsp84-1; Hsp84; Hsp90ab1; Hsp90; Hspcb", "protein_names_uniprotkb": "Heat shock protein HSP 90-beta; HSP 84; HSP84; Heat shock 84 kDa; TSTA; Tumor-specific transplantation 84 kDa antigen", "protein_names_refseq": "HSP 84; TSTA; heat shock 84 kDa; heat shock 90kDa protein 1, beta; heat shock protein 1, beta; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein HSP 90-beta; heat shock protein, 84 kDa 1; retinal degeneration slow protein; tumor-specific transplantation 84 kDa antigen", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); multiple sclerosis (Disease Ontology:DOID:2377); pulmonary fibrosis (Disease Ontology:DOID:3770); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); pancreatitis (Disease Ontology:DOID:4989); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (mmu:15516); (R-MMU-168928); (R-MMU-2029482); (R-MMU-3371497); (R-MMU-3371511); (R-MMU-3371568); (R-MMU-3371571); (R-MMU-399954); (R-MMU-6798695); (R-MMU-844456); (R-MMU-8852276); (R-MMU-8937144); (R-MMU-8939211); (R-MMU-9013418); (R-MMU-9018519)", "pathway_count": 15, "publication_count": 51, "publication_id_list": "10.1101/2023.09.13.557529;1406681;15345747;15642353;16139798;16393994;17208939;17242355;17622165;17947660;18034455;18630941;19131326;19144319;1976316;21183079;21689689;21750661;22556278;22645316;23806337;2445630;2469626;24788674;25605945;26495903;27496612;27686098;29187734;2925609;30084848;31219806;32152506;33300544;33649389;33725478;34428180;3458168;34887587;35820727;36288343;37453647;37507081;37828378;38658375;38750549;38992961;39142371;39627609;8289821;9798653", "class_list": "", "function": "ClassIIb histone deacetylase participates in perioperative neurocognitive disorders in elderly mice via HSP90/GR signaling pathway., [RefSeq, PubMed]; Dorsal root ganglion-derived exosomes deteriorate neuropathic pain by activating microglia via the microRNA-16-5p/HECTD1/HSP90 axis. Publication Status: Online-Only, [RefSeq, PubMed]; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery. Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription. Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10., [UniProtKB, UniProtKB]; SENP1-Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes Prevents Myocardial Fibrosis by Paracrine Signaling., [RefSeq, PubMed]; [Age-dependent expression of HSP90 in the hippocampus of APP/PS1 mice]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 6, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "O89078;Q3UIQ7", "ec_number_list": [], "go_molecular_function": "GO:0030911 TPR domain binding;GO:0032564 dATP binding;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0043066 negative regulation of apoptotic process;GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:2000010 positive regulation of protein localization to cell surface;GO:0034605 cellular response to heat", "synthesized_glycan_count": 0, "hit_score": 6.2, "record_id": "P11499-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VFV2-1", "uniprot_id": [ { "id": "Q8VFV2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VFV2", "type": "external" } ], "mass": 35908.0, "length": 317, "protein_name": "Olfactory receptor", "gene_name": "Or5a1", "organism": "Mouse", "refseq_name": "olfactory receptor family 5 subfamily A member 1", "refseq_ac": [ { "id": "NP_666893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666893", "type": "external" } ], "gene_names_uniprotkb": "Or5a1; Olfr76", "gene_names_refseq": "MOR215-3; Olfr76; Or5a1; V5", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2RE5P-2479601-2478648; olfactory receptor 76; olfactory receptor family 5 subfamily A member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:258677)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VFV2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXE0-1", "uniprot_id": [ { "id": "HACL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXE0", "type": "external" } ], "mass": 63660.0, "length": 581, "protein_name": "2-hydroxyacyl-CoA lyase 1", "gene_name": "Hacl1", "organism": "Mouse", "refseq_name": "2-hydroxyacyl-CoA lyase 1", "refseq_ac": [ { "id": "NP_064359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064359", "type": "external" } ], "gene_names_uniprotkb": "Hacl1; Hpcl; Phyh2", "gene_names_refseq": "1600020H07Rik; Hacl1; Hpcl; Phyh2", "protein_names_uniprotkb": "2-hydroxyacyl-CoA lyase 1; 2-HPCL; 2-hydroxyphytanoyl-CoA lyase; 4.1.2.63; Phytanoyl-CoA 2-hydroxylase 2", "protein_names_refseq": "2-HPCL; 2-hydroxyacyl-CoA lyase 1; 2-hydroxyphytanoyl-CoA lyase; phytanoyl-CoA 2-hydroxylase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:56794); (R-MMU-389599); (R-MMU-9033241)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "11171065;15644336;17208939;21750661;23806337;25428506;28629946;29027957;30084848;31599954;34428180;35055171;37453647", "class_list": "", "function": "2-hydroxyphytanoyl-CoA lyase has a role in the breakdown of long chain 2-hydroxyfatty acids, [RefSeq, PubMed]; Hacl1 plays a significant role in the liver and plasma levels of C17:0, providing evidence it can be endogenously biosynthesized via alpha-oxidation Publication Status: Online-Only, [RefSeq, PubMed]; Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner (By similarity). Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids (By similarity). Plays a significant role in the biosynthesis of heptadecanal in the liver (PubMed:29027957)., [UniProtKB, UniProtKB, PubMed]; Tissue Proteome of 2-Hydroxyacyl-CoA Lyase Deficient Mice Reveals Peroxisome Proliferation and Activation of omega-Oxidation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543K1;Q9DAV1", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "4.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.-", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016829 lyase activity;GO:0030976 thiamine pyrophosphate binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005777 peroxisome", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006631 fatty acid metabolic process;GO:0001561 fatty acid alpha-oxidation;GO:0006625 protein targeting to peroxisome;GO:0097089 methyl-branched fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9QXE0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAI6-1", "uniprot_id": [ { "id": "F135B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAI6", "type": "external" } ], "mass": 155524.0, "length": 1403, "protein_name": "Protein FAM135B", "gene_name": "Fam135b", "organism": "Mouse", "refseq_name": "protein FAM135B", "refseq_ac": [ { "id": "NP_808487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808487", "type": "external" } ], "gene_names_uniprotkb": "Fam135b", "gene_names_refseq": "1700010C24Rik; A830008O07Rik; Fam135b", "protein_names_uniprotkb": "Protein FAM135B", "protein_names_refseq": "protein FAM135B", "tax_id": 10090, "disease": "", "pathway": " (mmu:70363)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21750661;22517741;22645316;32848054;40885482", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9DAI6-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8T2-1", "uniprot_id": [ { "id": "GSDMD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8T2", "type": "external" } ], "mass": 53238.0, "length": 487, "protein_name": "Gasdermin-D", "gene_name": "Gsdmd", "organism": "Mouse", "refseq_name": "gasdermin-D", "refseq_ac": [ { "id": "NP_081236", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081236", "type": "external" } ], "gene_names_uniprotkb": "Gsdmd; Gsdmdc1", "gene_names_refseq": "1810036L03Rik; DF5L; Dfna5l; GsdmD-1; Gsdmdc1; Gsdmd; M2-4", "protein_names_uniprotkb": "Gasdermin-D; 13 kDa GSDMD; Gasdermin domain-containing protein 1; Gasdermin-D, 13 kDa", "protein_names_refseq": "gasdermin domain containing 1; gasdermin domain-containing protein 1; gasdermin-D; gasderminD-1", "tax_id": 10090, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:69146); (R-MMU-111457); (R-MMU-111458); (R-MMU-111461); (R-MMU-448706); (R-MMU-5620971); (R-MMU-5686938); (R-MMU-6798695); (R-MMU-9960519); (R-MMU-9960525)", "pathway_count": 10, "publication_count": 38, "publication_id_list": "18693275;21750661;22645316;26375003;26375259;26611636;27339137;27383986;27385778;27418190;29195811;29274245;29576317;30084848;30135078;30361383;30381458;31097341;32109412;32553275;32554464;32820063;33883744;34289345;34428180;35705808;35749514;35794369;36227980;36599845;37001519;37327784;37988464;38324683;38530158;38538834;38599239;38632402", "class_list": "", "function": "Identification of gasdermin D (Gsdmd) by genome-wide clustered regularly interspaced palindromic repeat (CRISPR)-Cas9 nuclease screens of caspase-11- and caspase-1-mediated pyroptosis in mouse bone marrow macrophages, [RefSeq, PubMed]; Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:26611636, PubMed:27383986, PubMed:27385778, PubMed:27418190). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-D, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:26375003, PubMed:26375259, PubMed:26611636, PubMed:27383986, PubMed:27385778, PubMed:27418190)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Produced by the cleavage by papain allergen (PubMed:35794369). After cleavage, moves to the plasma membrane and homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the specific release of mature interleukin-33 (IL33), promoting type 2 inflammatory immune response (PubMed:35749514, PubMed:35794369)., [UniProtKB, PubMed, PubMed]; Promotes pyroptosis in response to microbial infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:26611636, PubMed:27383986, PubMed:27385778, PubMed:27418190, PubMed:32820063, PubMed:34289345, PubMed:35705808, PubMed:37988464, PubMed:38530158, PubMed:38538834, PubMed:38632402). Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4/CASP11 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators (PubMed:26375003, PubMed:26375259, PubMed:26611636, PubMed:27383986, PubMed:27385778, PubMed:27418190, PubMed:35705808, PubMed:38632402). After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to phosphatidic acid and phosphatidylserine (PubMed:27339137, PubMed:27383986). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the release of mature interleukin-1 (IL1B and IL18) and triggering pyroptosis (PubMed:27383986, PubMed:29195811, PubMed:29274245, PubMed:33883744, PubMed:38530158, PubMed:38538834). Gasdermin pores also allow the release of mature caspase-7 (CASP7) (PubMed:35705808). In some, but not all, cells types, pyroptosis is followed by pyroptotic cell death, which is caused by downstream activation of ninjurin-1 (NINJ1), which mediates membrane rupture (cytolysis) (PubMed:38632402). Also forms pores in the mitochondrial membrane, resulting in release of mitochondrial DNA (mtDNA) into the cytosol (PubMed:37001519). Gasdermin-D, N-terminal released from pyroptotic cells into the extracellular milieu rapidly binds to and kills both Gram-negative and Gram-positive bacteria, without harming neighboring mammalian cells, as it does not disrupt the plasma membrane from the outside due to lipid-binding specificity (PubMed:27383986). Under cell culture conditions, also active against intracellular bacteria, such as Listeria monocytogenes (PubMed:27383986). Also active in response to MAP3K7/TAK1 inactivation by Yersinia toxin YopJ, which triggers cleavage by CASP8 and subsequent activation (PubMed:30361383, PubMed:30381458). Required for mucosal tissue defense against enteric pathogens (PubMed:37988464). Activation of the non-canonical inflammasome in brain endothelial cells can lead to excessive pyroptosis, leading to blood-brain barrier breakdown (PubMed:38632402). Strongly binds to bacterial and mitochondrial lipids, including cardiolipin. Does not bind to unphosphorylated phosphatidylinositol, phosphatidylethanolamine nor phosphatidylcholine (PubMed:27383986)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This study clearly shows that Gsdmd is not essential for development of mouse intestinal tract or epithelial cell differentiation., [RefSeq, PubMed]; Transcription coactivator produced by the cleavage by CASP3 or CASP7 in the upper small intestine in response to dietary antigens (PubMed:37327784). Required to maintain food tolerance in small intestine: translocates to the nucleus and acts as a coactivator for STAT1 to induce the transcription of CIITA and MHC class II molecules, which in turn induce type 1 regulatory T (Tr1) cells in upper small intestine (PubMed:37327784)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 42, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBD9", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0001786 phosphatidylserine binding;GO:0070300 phosphatidic acid binding;GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0070498 interleukin-1-mediated signaling pathway;GO:0032741 positive regulation of interleukin-18 production;GO:0044546 NLRP3 inflammasome complex assembly;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "Q9D8T2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JEE1-1", "uniprot_id": [ { "id": "A0A0G2JEE1_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0G2JEE1", "type": "external" } ], "mass": 12107.0, "length": 113, "protein_name": "Immunoglobulin kappa chain variable 18-36", "gene_name": "Igkv18-36", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Igkv18-36", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin kappa chain variable 18-36", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0071748 monomeric IgA immunoglobulin complex;GO:0071751 secretory IgA immunoglobulin complex;GO:0071756 pentameric IgM immunoglobulin complex", "go_biological_process": "GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JEE1-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VFF7-1", "uniprot_id": [ { "id": "Q8VFF7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VFF7", "type": "external" } ], "mass": 35584.0, "length": 317, "protein_name": "Olfactory receptor", "gene_name": "Or7e169", "organism": "Mouse", "refseq_name": "olfactory receptor 860", "refseq_ac": [ { "id": "NP_666739", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666739", "type": "external" } ], "gene_names_uniprotkb": "Or7e169; Olfr860", "gene_names_refseq": "MOR146-2; Olfr860; Or7e169", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PVTD-13586614-13585661; olfactory receptor 860; olfactory receptor MOR146-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:258521)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VFF7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV60-1", "uniprot_id": [ { "id": "GSK3B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WV60", "type": "external" } ], "mass": 46710.0, "length": 420, "protein_name": "Glycogen synthase kinase-3 beta", "gene_name": "Gsk3b", "organism": "Mouse", "refseq_name": "glycogen synthase kinase-3 beta isoform 1", "refseq_ac": [ { "id": "NP_062801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062801", "type": "external" } ], "gene_names_uniprotkb": "Gsk3b", "gene_names_refseq": "7330414F15Rik; 8430431H08Rik; GSK-3beta; GSK-3; GSK3; Gsk3b", "protein_names_uniprotkb": "Glycogen synthase kinase-3 beta; 2.7.11.1; 2.7.11.26; GSK-3 beta; Serine/threonine-protein kinase GSK3B", "protein_names_refseq": "glycogen synthase kinase-3 beta isoform 1; serine/threonine-protein kinase GSK3B", "tax_id": 10090, "disease": "diabetic encephalopathy (Disease Ontology:DOID:0050850); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); sciatic neuropathy (Disease Ontology:DOID:11446); Parkinson's disease (Disease Ontology:DOID:14330); depressive disorder (Disease Ontology:DOID:1596); status epilepticus (Disease Ontology:DOID:1824); colon cancer (Disease Ontology:DOID:219); endometrial carcinoma (Disease Ontology:DOID:2871); substance-related disorder (Disease Ontology:DOID:303); bipolar disorder (Disease Ontology:DOID:3312); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); vascular dementia (Disease Ontology:DOID:8725); degenerative disc disease (Disease Ontology:DOID:90); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (mmu:56637); (R-MMU-195253); (R-MMU-196299); (R-MMU-3371453); (R-MMU-399956); (R-MMU-4641262); (R-MMU-5250924); (R-MMU-5610785); (R-MMU-69601); (R-MMU-9762114); (R-MMU-9856649); (R-MMU-9929356)", "pathway_count": 12, "publication_count": 183, "publication_id_list": "10894547;11959983;12095987;12489109;12504922;14745448;14749383;15039769;15345747;15659239;15791206;15878878;15888552;15980066;16039605;16051150;16374520;16434614;16489037;16501492;16510873;16522636;16530186;16543145;16565488;16611981;16762022;16855914;16941690;16954147;16987252;17053159;17241269;17242355;17391670;17475833;17560576;17714451;17975737;18288891;18322105;18701453;18801732;18824542;19011050;19070648;19106302;19126599;19141611;19303846;19328817;19356803;19379814;19622347;19818092;19939226;20049328;20111716;20123978;20300527;20332342;20354135;20592205;20690801;21079728;21295697;21540081;21544852;21659643;21671257;21750661;21821713;21998135;22019984;22022450;22057101;22064483;22238573;22422579;22434044;22471389;22539723;22645316;22672822;22714712;23051669;23239877;23301857;23324178;23369342;23395175;23444402;23455548;23542741;23628704;23807397;23816813;23853095;24025512;24227739;24278135;24462873;24519956;24670930;24675832;24742671;24788685;24969778;24983010;24987368;25029272;25073924;25107557;25172181;25355398;25477508;25733715;25972359;26240334;26274564;26342176;26582204;26750157;26854125;26872261;26883430;26950856;27000529;27074656;27287266;27497480;27568038;27688851;27778132;27827363;28005221;28098160;28114284;28146408;28228716;28556462;28591721;28646232;28764929;28819213;28832021;28865114;28903391;28967903;29058041;29073967;29127434;29142209;29331582;29434807;29452207;29504933;29670081;29753049;29951166;30021941;30075764;30252210;30768733;31119045;31155593;31222110;31233346;31409917;31707362;31900153;32848054;33066035;33300544;33495840;33807180;34428180;35622272;36090685;36104259;37033243;39719712;40885482", "class_list": "", "function": "Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1 (PubMed:15791206, PubMed:22057101, PubMed:23395175). Requires primed phosphorylation of the majority of its substrates (PubMed:15791206, PubMed:22057101, PubMed:23395175). In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (By similarity). May also mediate the development of insulin resistance by regulating activation of transcription factors (By similarity). Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase (By similarity). In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes (By similarity). Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA (By similarity). Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin (By similarity). Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules (By similarity). MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease (By similarity). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (By similarity). Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair (PubMed:21295697). Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF (TNF/TNFA) (PubMed:10894547). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes (PubMed:18288891). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (PubMed:16543145). Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin (By similarity). Is necessary for the establishment of neuronal polarity and axon outgrowth (PubMed:17391670). Phosphorylates MARK2, leading to inhibition of its activity (By similarity). Phosphorylates SIK1 at 'Thr-182', leading to sustainment of its activity (By similarity). Phosphorylates ZC3HAV1 which enhances its antiviral activity (By similarity). Phosphorylates SNAI1, leading to its ubiquitination and proteasomal degradation (By similarity). Phosphorylates SFPQ at 'Thr-687' upon T-cell activation (By similarity). Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation (By similarity). Regulates the circadian clock via phosphorylation of the major clock components including BMAL1, CLOCK and PER2 (PubMed:20049328, PubMed:20123978, PubMed:28556462, PubMed:28903391). Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation (By similarity). Phosphorylates BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation (PubMed:20049328, PubMed:28903391). Phosphorylates FBXL2 at 'Thr-404' and primes it for ubiquitination by the SCF(FBXO3) complex and proteasomal degradation (PubMed:23542741). Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity (By similarity). Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (By similarity). Regulates the circadian rhythmicity of hippocampal long-term potentiation and BMAL1 and PER2 expression (PubMed:28556462). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, activating KAT5/TIP60 acetyltransferase activity and promoting acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:22539723). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors (By similarity). Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B (By similarity). The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity). Phosphorylates E2F1, promoting the interaction between E2F1 and USP11, stabilizing E2F1 and promoting its activity (By similarity). Phosphorylates mTORC2 complex component RICTOR at 'Ser-1235' in response to endoplasmic stress, inhibiting mTORC2 (By similarity). Acts as a negative regulator of smoothened signaling by mediating phosphorylation of GLI2 and GLI3 in absence of smoothened, promoting their processing by the SCF(BTRC) complex (PubMed:16611981, PubMed:19622347). Phosphorylates FXR1, promoting FXR1 ubiquitination by the SCF(FBXO4) complex and FXR1 degradation by the proteasome (PubMed:26240334, PubMed:29142209). Phosphorylates interleukin-22 receptor subunit IL22RA1, preventing its proteasomal degradation (PubMed:24742671). Phosphorylates and inhibits the CTP synthase and protein-asparagine deamidase activities of CTPS1 (PubMed:39719712). Phosphorylates DSP at multiple sequential serine residues in the C-terminus tail, promoting its recruitment to developing desmosome cell-cell junctions (PubMed:25733715)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 22, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": 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"url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0002020 protease binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005178 integrin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0050770 regulation of axonogenesis;GO:0014043 negative regulation of neuron maturation;GO:0002183 cytoplasmic translational initiation;GO:0035733 hepatic stellate cell activation", "synthesized_glycan_count": 0, "hit_score": 18.9, "record_id": "Q9WV60-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63085-1", "uniprot_id": [ { "id": "MK01_MOUSE", "url": "https://www.uniprot.org/uniprot/P63085", "type": "external" } ], "mass": 41276.0, "length": 358, "protein_name": "Mitogen-activated protein kinase 1", "gene_name": "Mapk1", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase 1", "refseq_ac": [ { "id": "NP_001033752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033752", "type": "external" } ], "gene_names_uniprotkb": "Mapk1; Erk2; Mapk; Prkm1", "gene_names_refseq": "9030612K14Rik; ERK; Erk2; MAPK2; Mapk1; PRKM2; Prkm1; p41mapk; p42mapk", "protein_names_uniprotkb": "Mitogen-activated protein kinase 1; 2.7.11.24; ERK-2; ERT1; Extracellular signal-regulated kinase 2; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; MAPK 1; MAPK 2; Mitogen-activated protein kinase 2; p42-MAPK", "protein_names_refseq": "ERK-2; ERT1; MAP kinase 1; MAP kinase 2; MAPK 1; MAPK 2; extracellular signal-regulated kinase 2; mitogen-activated protein kinase 1; mitogen-activated protein kinase 2; p42-MAPK", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); renal fibrosis (Disease Ontology:DOID:0050855); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); Noonan syndrome 13 (Disease Ontology:DOID:0112161); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); gastric ulcer (Disease Ontology:DOID:10808); urethral obstruction (Disease Ontology:DOID:12577); velocardiofacial syndrome (Disease Ontology:DOID:12583); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); thyroid cancer (Disease Ontology:DOID:1781); melanoma (Disease Ontology:DOID:1909); colon cancer (Disease Ontology:DOID:219); colon adenocarcinoma (Disease Ontology:DOID:234); prostate adenocarcinoma (Disease Ontology:DOID:2526); morphine dependence (Disease Ontology:DOID:2560); endometrial adenocarcinoma (Disease Ontology:DOID:2870); endometrial carcinoma (Disease Ontology:DOID:2871); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); coronary restenosis (Disease Ontology:DOID:4247); Weissenbacher-Zweymuller syndrome (Disease Ontology:DOID:4258); renal cell carcinoma (Disease Ontology:DOID:4450); ureteral obstruction (Disease Ontology:DOID:5199); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); childhood pilocytic astrocytoma (Disease Ontology:DOID:6812); hepatocellular carcinoma (Disease Ontology:DOID:684); cocaine abuse (Disease Ontology:DOID:809); vascular dementia (Disease Ontology:DOID:8725); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:26413); (R-MMU-111995); (R-MMU-112409); (R-MMU-112411); (R-MMU-1181150); (R-MMU-1295596); (R-MMU-1502540); (R-MMU-162658); (R-MMU-170968); (R-MMU-198753); (R-MMU-202670); (R-MMU-2029482); (R-MMU-2173795); (R-MMU-2173796); (R-MMU-2559580); (R-MMU-2559582); (R-MMU-2559585); (R-MMU-2871796); (R-MMU-3371453); (R-MMU-375165); (R-MMU-437239); (R-MMU-445144); (R-MMU-450341); (R-MMU-456926); (R-MMU-5654726); (R-MMU-5654727); (R-MMU-5654732); (R-MMU-5654733); (R-MMU-5663213); (R-MMU-5668599); (R-MMU-5673001); (R-MMU-5674135); (R-MMU-5674499); (R-MMU-5675221); (R-MMU-6798695); (R-MMU-6811558); (R-MMU-74749); (R-MMU-877300); (R-MMU-881907); (R-MMU-8939211); (R-MMU-9627069); (R-MMU-9634635); (R-MMU-9634638); (R-MMU-9732724); (R-MMU-982772); (R-MMU-9856649)", "pathway_count": 46, "publication_count": 53, "publication_id_list": "10080542;10704462;10753946;11090077;11684667;11702783;11726647;12134156;12223545;12925581;14744933;15118098;15284227;15314156;15899793;15923189;16162500;16251435;16393692;16479539;1649458;17242355;17947660;18034455;18299400;1849075;19131326;19565474;20173027;21183079;21262971;21750661;21779493;21952136;22022510;25605945;26240334;26495903;26658610;26740625;27783954;28011936;30084848;31052420;31219806;32265441;34428180;35984892;36210013;37828378;8221888;8444355;8626447", "class_list": "", "function": "Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity., [UniProtKB, UniProtKB]; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1 and FXR1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2, GLI1 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in response to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity). Phosphorylates phosphoglycerate kinase PGK1 under hypoxic conditions to promote its targeting to the mitochondrion and suppress the formation of acetyl-coenzyme A from pyruvate (By similarity). Phosphorylates GJA1 at 'Ser-279' and 'Ser-282' resulting in an increase in GJA1 ubiquitination and ultimately lysosomal degradation (By similarity). Acts as a positive regulator of smoothened signaling by mediating phosphorylation of GLI1 in response to smoothened activation, promoting its dissociation from SUFU inhibitor and translocation to the nucleus (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 41, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P27703;Q3V1U6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "1.11.1.27", "url": 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"3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005769 early endosome", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0072584 caveolin-mediated endocytosis;GO:2000641 regulation of early endosome to late endosome transport;GO:0030878 thyroid gland development;GO:0019858 cytosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 5.4, "record_id": "P63085-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PGN1-1", "uniprot_id": [ { "id": "ERFE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PGN1", "type": "external" } ], "mass": 36265.0, "length": 340, "protein_name": "Erythroferrone", "gene_name": "Erfe", "organism": "Mouse", "refseq_name": "erythroferrone precursor", "refseq_ac": [ { "id": "NP_775571", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775571", "type": "external" } ], "gene_names_uniprotkb": "Erfe; C1qtnf15; Ctrp15; Fam132b", "gene_names_refseq": "4832406C22; Erfe; Fam132b; myonectin", "protein_names_uniprotkb": "Erythroferrone; Complement C1q tumor necrosis factor-related protein 15; Myonectin", "protein_names_refseq": "complement C1q tumor necrosis factor-related protein 15; erythroferrone precursor; family with sequence similarity 132, member B; protein FAM132B", "tax_id": 10090, "disease": "", "pathway": " (mmu:227358)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "21750661;22351773;24187137;24880340;25193872;25428506;30097509;30566056;31800957;32602701;34002695;34614145;37542026;37828378", "class_list": "", "function": "Compared with wild-type mice, Fam132b-deficient mice exhibited a more severe anemia, had higher hepcidin levels and consequently lower serum iron concentration on days 14 and 21, and manifested impaired mobilization of iron from stores (liver and spleen)., [RefSeq, PubMed]; Erythroid overproduction of erythroferrone causes iron overload and developmental abnormalities in mice., [RefSeq, PubMed]; Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores (PubMed:24880340, PubMed:30097509, PubMed:31800957, PubMed:34002695). Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake (PubMed:22351773). Inhibits apoptosis and inflammatory response in cardiomyocytes via promotion of sphingosine-1-phosphate (S1P) and cAMP-dependent activation of AKT signaling (PubMed:30566056). Inhibits autophagy induced by nutrient deficiency in hepatocytes via promoting the phosphorylation of IRS1, AKT, and MTOR, and thereby subsequent activation of the AKT-MTOR signaling pathway (PubMed:24187137). Negatively regulates the differentiation of osteoblasts, potentially via sequestering BMP2, and thereby inhibits the activation of SMAD signaling (PubMed:34002695). The reduction in BMP2 signaling in osteoblasts also results in an increase in expression of the osteoclastogenesis-promoting factors TNFSF11/RANKL and SOST, thereby indirectly promotes bone resorption (PubMed:34002695)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Myonectin is a novel regulator of cellular autophagy, [RefSeq, PubMed]; Myonectin protects against skeletal muscle dysfunction in male mice through activation of AMPK/PGC1alpha pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E3VWA0;Q8CE11", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005179 hormone activity;GO:0140313 molecular sequestering activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0006879 intracellular iron ion homeostasis;GO:0019217 regulation of fatty acid metabolic process;GO:0010507 negative regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q6PGN1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BYW9-1", "uniprot_id": [ { "id": "EOGT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BYW9", "type": "external" } ], "mass": 61446.0, "length": 527, "protein_name": "EGF domain-specific O-linked N-acetylglucosamine transferase", "gene_name": "Eogt", "organism": "Mouse", "refseq_name": "EGF domain-specific O-linked N-acetylglucosamine transferase precursor", "refseq_ac": [ { "id": "NP_780522", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780522", "type": "external" } ], "gene_names_uniprotkb": "Eogt; A130022J15Rik; Aer61; Eogt1", "gene_names_refseq": "A130022J15Rik; Aer61; Eogt", "protein_names_uniprotkb": "EGF domain-specific O-linked N-acetylglucosamine transferase; 2.4.1.255; Extracellular O-linked N-acetylglucosamine transferase", "protein_names_refseq": "EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase; EGF domain-specific O-linked N-acetylglucosamine transferase precursor; extracellular O-linked N-acetylglucosamine transferase", "tax_id": 10090, "disease": "Adams-Oliver syndrome (Disease Ontology:DOID:0060227)", "pathway": " (mmu:101351)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22310717;23522784;30899004;32376684;34428180;37838775", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains., [UniProtKB, PubMed]; EOGT enables residual Notch signaling in mouse intestinal cells lacking POFUT1. Publication Status: Online-Only, [RefSeq, PubMed]; N-Glycans on EGF domain-specific O-GlcNAc transferase (EOGT) facilitate EOGT maturation and peripheral endoplasmic reticulum localization., [RefSeq, PubMed]; The characterization of A130022J15Rik, a mouse gene homolog of Drosophila Eogt (Eogt 1), was reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 27, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.255", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.255", "type": "external" } ], "go_molecular_function": "GO:0097363 protein O-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006493 protein O-linked glycosylation", "synthesized_glycan_count": 5, "hit_score": 1.3, "record_id": "Q8BYW9-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000100000000.110.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70194-1", "uniprot_id": [ { "id": "EIF3D_MOUSE", "url": "https://www.uniprot.org/uniprot/O70194", "type": "external" } ], "mass": 63989.0, "length": 548, "protein_name": "Eukaryotic translation initiation factor 3 subunit D", "gene_name": "Eif3d", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 3 subunit D", "refseq_ac": [ { "id": "NP_061219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061219", "type": "external" } ], "gene_names_uniprotkb": "Eif3d; Eif3s7", "gene_names_refseq": "66/67kDa; Eif3d; Eif3s7; eIF3p66", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit D; Eukaryotic translation initiation factor 3 subunit 7; eIF-3-zeta; eIF3 p66; eIF3d", "protein_names_refseq": "eIF-3-zeta; eukaryotic translation initiation factor 3 subunit 7; eukaryotic translation initiation factor 3 subunit D; eukaryotic translation initiation factor 3, subunit 7 (zeta); translation initiation factor eIF3 p66", "tax_id": 10090, "disease": "", "pathway": " (mmu:55944); (R-MMU-156827); (R-MMU-72649); (R-MMU-72689); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706)", "pathway_count": 7, "publication_count": 14, "publication_id_list": "17242355;17581632;21183079;21750661;23806337;25428506;28011936;29187734;34203471;34428180;34887587;35820727;37453647;37828378", "class_list": "", "function": "mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLH0;Q8BWW1", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity;GO:0098808 mRNA cap binding", "go_cellular_component": "GO:0005829 cytosol;GO:0045202 synapse;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m", "go_biological_process": "GO:0075522 IRES-dependent viral translational initiation;GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex;GO:0075525 viral translational termination-reinitiation;GO:0002191 cap-dependent translational initiation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O70194-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61521-1", "uniprot_id": [ { "id": "EREG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61521", "type": "external" } ], "mass": 18474.0, "length": 162, "protein_name": "Proepiregulin", "gene_name": "Ereg", "organism": "Mouse", "refseq_name": "proepiregulin preproprotein", "refseq_ac": [ { "id": "NP_031976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031976", "type": "external" } ], "gene_names_uniprotkb": "Ereg", "gene_names_refseq": "EPR; Ereg", "protein_names_uniprotkb": "Proepiregulin", "protein_names_refseq": "proepiregulin preproprotein; proepiregulin", "tax_id": 10090, "disease": "extrapulmonary tuberculosis (Disease Ontology:DOID:0050598); pulmonary tuberculosis (Disease Ontology:DOID:2957); tuberculosis (Disease Ontology:DOID:399); cholesteatoma (Disease Ontology:DOID:869)", "pathway": " (mmu:13874); (R-MMU-1227986); (R-MMU-1236394); (R-MMU-1250196); (R-MMU-1250342); (R-MMU-1250347); (R-MMU-1257604); (R-MMU-177929); (R-MMU-179812); (R-MMU-180292); (R-MMU-180336); (R-MMU-182971); (R-MMU-1963640); (R-MMU-1963642); (R-MMU-212718); (R-MMU-5673001); (R-MMU-6785631); (R-MMU-6811558); (R-MMU-8847993); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-8863795); (R-MMU-9009391)", "pathway_count": 23, "publication_count": 4, "publication_id_list": "24631357;37070602;7706296;8549764", "class_list": "", "function": "Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (By similarity). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357)., [UniProtKB, UniProtKB, PubMed]; LncRNA EPR regulates intestinal mucus production and protects against inflammation and tumorigenesis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7M0A8", "ec_number_list": [], "go_molecular_function": "GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007267 cell-cell signaling;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0032755 positive regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q61521-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99K30-1", "uniprot_id": [ { "id": "ES8L2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99K30", "type": "external" } ], "mass": 82229.0, "length": 729, "protein_name": "Epidermal growth factor receptor kinase substrate 8-like protein 2", "gene_name": "Eps8l2", "organism": "Mouse", "refseq_name": "epidermal growth factor receptor kinase substrate 8-like protein 2", "refseq_ac": [ { "id": "NP_573454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573454", "type": "external" } ], "gene_names_uniprotkb": "Eps8l2; Eps8r2", "gene_names_refseq": "Eps8l2; Eps8r2", "protein_names_uniprotkb": "Epidermal growth factor receptor kinase substrate 8-like protein 2; EPS8-like protein 2; EPS8-related protein 2; Epidermal growth factor receptor pathway substrate 8-related protein 2", "protein_names_refseq": "EPS8 related protein 2; EPS8-like protein 2; epidermal growth factor receptor kinase substrate 8-like protein 2; epidermal growth factor receptor pathway substrate 8-like protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 106 (Disease Ontology:DOID:0080261); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:98845)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;14565974;17242355;21183079;21750661;23918390;31219806;34428180", "class_list": "", "function": "Eps8L2 is required for the long-term maintenance of the staircase structure and mechanosensory function of auditory hair bundles., [RefSeq, PubMed]; Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity). In the cochlea, is required for stereocilia maintenance in adult hair cells (PubMed:23918390)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9630, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q91VT7", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0051015 actin filament binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032587 ruffle membrane;GO:0001726 ruffle", "go_biological_process": "GO:0007266 Rho protein signal transduction;GO:0016601 Rac protein signal transduction;GO:0035023 regulation of Rho protein signal transduction;GO:0007605 sensory perception of sound;GO:1900029 positive regulation of ruffle assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99K30-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80X90-1", "uniprot_id": [ { "id": "FLNB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80X90", "type": "external" } ], "mass": 277825.0, "length": 2602, "protein_name": "Filamin-B", "gene_name": "Flnb", "organism": "Mouse", "refseq_name": "filamin-B isoform a", "refseq_ac": [ { "id": "NP_001074896", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074896", "type": "external" } ], "gene_names_uniprotkb": "Flnb", "gene_names_refseq": "Fln-b; Flnb", "protein_names_uniprotkb": "Filamin-B; ABP-280-like protein; Actin-binding-like protein; Beta-filamin; FLN-B", "protein_names_refseq": "ABP-280-like protein; actin binding protein 278; actin-binding-like protein; beta-filamin; filamin-B isoform a; filamin-B", "tax_id": 10090, "disease": "atelosteogenesis (Disease Ontology:DOID:0050648); Boomerang dysplasia (Disease Ontology:DOID:0050680); spinal disease (Disease Ontology:DOID:0060564); bone development disease (Disease Ontology:DOID:0080006); myofibrillar myopathy 5 (Disease Ontology:DOID:0080096); spondylocarpotarsal synostosis syndrome (Disease Ontology:DOID:0090116); distal myopathy 4 (Disease Ontology:DOID:0111190); clubfoot (Disease Ontology:DOID:11836); Larsen syndrome (Disease Ontology:DOID:14764); osteochondrodysplasia (Disease Ontology:DOID:2256); myopathy (Disease Ontology:DOID:423); cleft palate (Disease Ontology:DOID:674)", "pathway": " (mmu:286940); (R-MMU-1169408)", "pathway_count": 2, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;11807098;12393796;15592455;21709252;22645316;22872234;23806337;23890175;24436304;24788674;25153642;25428506;26343497;28011936;30084848;31219806;31599954;34203471;34418053;34428180;34887587;35984892;37003352;37453647;37507081;37828378", "class_list": "", "function": "Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton (By similarity)., [UniProtKB]; Rare loss-of-function variants in FLNB cause non-syndromic orofacial clefts., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 12, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QNV9;Q8VHX4;Q8VHX7;Q99KY3", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0005925 focal adhesion", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0003334 keratinocyte development;GO:0003382 epithelial cell morphogenesis;GO:0071346 cellular response to type II interferon;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q80X90-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BLU0-1", "uniprot_id": [ { "id": "FLRT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BLU0", "type": "external" } ], "mass": 73948.0, "length": 660, "protein_name": "Leucine-rich repeat transmembrane protein FLRT2", "gene_name": "Flrt2", "organism": "Mouse", "refseq_name": "leucine-rich repeat transmembrane protein FLRT2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_958926", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958926", "type": "external" } ], "gene_names_uniprotkb": "Flrt2; Kiaa0405", "gene_names_refseq": "Flrt2", "protein_names_uniprotkb": "Leucine-rich repeat transmembrane protein FLRT2; Fibronectin leucine rich transmembrane protein 2", "protein_names_refseq": "leucine-rich repeat transmembrane protein FLRT2 isoform 1 precursor; leucine-rich repeat transmembrane protein FLRT2", "tax_id": 10090, "disease": "", "pathway": " (mmu:399558); (R-MMU-5654687)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;16872596;18448090;21350012;21673655;21765038;22405201;24585683;25374360;25728924;38587072", "class_list": "", "function": "FLRT2 is expressed in a subset of the sclerotome, adjacent to the region that forms the syndetome in embryo, [RefSeq, PubMed]; FLRT2 prevents endothelial cell senescence and vascular aging by regulating the ITGB4/mTORC2/p53 signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:21350012, PubMed:25374360, PubMed:25728924). May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D (PubMed:21673655). Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members (PubMed:21673655, PubMed:25728924). Plays a role in fibroblast growth factor-mediated signaling cascades (PubMed:16872596). Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis (PubMed:21350012)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6A073", "ec_number_list": [], "go_molecular_function": "GO:0045499 chemorepellent activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005925 focal adhesion", "go_biological_process": "GO:0003007 heart morphogenesis;GO:0007411 axon guidance;GO:2001222 regulation of neuron migration;GO:0008543 fibroblast growth factor receptor signaling pathway;GO:0071711 basement membrane organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BLU0-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1M2-1", "uniprot_id": [ { "id": "H2AJ_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1M2", "type": "external" } ], "mass": 14045.0, "length": 129, "protein_name": "Histone H2A.J", "gene_name": "H2aj", "organism": "Mouse", "refseq_name": "histone H2A.J", "refseq_ac": [ { "id": "NP_808356", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808356", "type": "external" } ], "gene_names_uniprotkb": "H2aj", "gene_names_refseq": "E130307C13; H2afj; H2aj", "protein_names_uniprotkb": "Histone H2A.J; H2a/j", "protein_names_refseq": "H2A histone family, member J; H2a/j; histone H2A.J", "tax_id": 10090, "disease": "", "pathway": " (mmu:232440); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-606279); (R-MMU-8936459); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 14, "publication_count": 9, "publication_id_list": "21750661;23806337;33300544;35984892;36288343;36608439;36980257;37453647;37507081", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, UniProtKB, UniProtKB]; Hepatocyte-derived exosomes deliver H2AFJ to hepatic stellate cells and promote liver fibrosis via the MAPK/STMN1 axis activation., [RefSeq, PubMed]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is located on chromosome 6 and encodes a replication-independent histone that is member of the histone H2A family. [provided by RefSeq, Nov 2015]., [RefSeq]; Role of Histone Variant H2A.J in Fine-Tuning Chromatin Organization for the Establishment of Ionizing Radiation-Induced Senescence. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8R1M2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NVF4-1", "uniprot_id": [ { "id": "HELB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NVF4", "type": "external" } ], "mass": 121471.0, "length": 1074, "protein_name": "DNA helicase B", "gene_name": "Helb", "organism": "Mouse", "refseq_name": "DNA helicase B", "refseq_ac": [ { "id": "NP_536694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536694", "type": "external" } ], "gene_names_uniprotkb": "Helb", "gene_names_refseq": "D10Ertd664e; Helb", "protein_names_uniprotkb": "DNA helicase B; 5.6.2.3; DNA 5'-3' helicase B; DNA-dependent ATPase B", "protein_names_refseq": "DNA helicase B", "tax_id": 10090, "disease": "", "pathway": " (mmu:117599)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11557815;17242355;21183079;21750661;25605945;26774285;27802388;2966639;30084848;3038170;30779550;31219806;31599954;34428180;35820727;36210013;7596831;7794903", "class_list": "", "function": "5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:26774285). Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285). Acts independently of TP53BP1 (PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity (PubMed:2966639). Has single-strand DNA-dependent ATPase and DNA helicase activities (PubMed:3038170). Prefers ATP and dATP as substrates (PubMed:2966639, PubMed:3038170). During S phase, may facilitate cellular recovery from replication stress (PubMed:11557815, PubMed:7596831, PubMed:7794903)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Conclude that mammalian DNA end resection triggers its own inhibition via the recruitment of HELB., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G5E835;Q6KAT5;Q8C930;Q9EQT8", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0044877 protein-containing complex binding;GO:0003678 DNA helicase activity;GO:0043139 5'-3' DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0006260 DNA replication;GO:0006974 DNA damage response;GO:0006269 DNA replication, synthesis of primer;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q6NVF4-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84244-1", "uniprot_id": [ { "id": "H33_MOUSE", "url": "https://www.uniprot.org/uniprot/P84244", "type": "external" } ], "mass": 15328.0, "length": 136, "protein_name": "Histone H3.3", "gene_name": "H3-3a; H3-3b; H3f3a", "organism": "Mouse", "refseq_name": "histone H3.3", "refseq_ac": [ { "id": "NP_032236", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032236", "type": "external" } ], "gene_names_uniprotkb": "H3-3a; H3-3b; H3f3a; H3.3a; H3.3b; H3f3a; H3f3b", "gene_names_refseq": "EyeLinc14; H3-3a; H3-3b; H3.3A; H3f3a", "protein_names_uniprotkb": "Histone H3.3", "protein_names_refseq": "H3 histone, family 3A; histone H3.3", "tax_id": 10090, "disease": "Bryant-Li-Bhoj neurodevelopmental syndrome 1 (Disease Ontology:DOID:0051011); Bryant-Li-Bhoj neurodevelopmental syndrome 2 (Disease Ontology:DOID:0051012); diffuse midline glioma, H3 K27-altered (Disease Ontology:DOID:0080684)", "pathway": " (mmu:15078); (mmu:15081); (R-MMU-212300); (R-MMU-2299718); (R-MMU-8936459); (R-MMU-9018519); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-983231); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 13, "publication_count": 35, "publication_id_list": "10464286;11441012;11751582;11856369;12498683;13678296;15339660;15485929;15616592;15638457;15681610;15684425;15735677;15870105;17189264;17194708;20122409;21750661;21925322;22389435;24681537;2470025;27105113;27105115;30154464;30279482;30867594;31645732;33300544;35451487;36656301;39627609;8265661;9174168;9373943", "class_list": "", "function": "A knockout-first model of H3f3a gene targeting leads to developmental lethality., [RefSeq, PubMed]; Histone H3.3 phosphorylation promotes heterochromatin formation by inhibiting H3K9/K36 histone demethylase., [RefSeq, PubMed]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq, Nov 2015]., [RefSeq]; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P06351;P33155;Q3TW79;Q3U6D6;Q569U8;Q5HZY8;Q6TXQ5;Q8VDJ2;Q9D0H3;Q9V3W4", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000776 kinetochore;GO:0000781 chromosome, telomeric region;GO:0000786 nucleosome", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0030307 positive regulation of cell growth;GO:0006334 nucleosome assembly;GO:0007080 mitotic metaphase chromosome alignment;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P84244-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36552-1", "uniprot_id": [ { "id": "HEM6_MOUSE", "url": "https://www.uniprot.org/uniprot/P36552", "type": "external" } ], "mass": 49715.0, "length": 443, "protein_name": "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial", "gene_name": "Cpox", "organism": "Mouse", "refseq_name": "oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_031783", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031783", "type": "external" } ], "gene_names_uniprotkb": "Cpox; Cpo", "gene_names_refseq": "CPX; Cpox; Cpo; HCP; M100835; Rgsc835; cac; nct", "protein_names_uniprotkb": "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial; 1.3.3.3; COX; Coprogen oxidase; Coproporphyrinogenase", "protein_names_refseq": "COX; Coproporphyrinogen III oxidase, mitochondrial precursor (Coproporphyrinogenase) (Coprogen oxidase) (COX); clone 560; coprogen oxidase; coproporphyrinogen-III oxidase, mitochondrial; coproporphyrinogenase; oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial precursor; oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial", "tax_id": 10090, "disease": "hereditary coproporphyria (Disease Ontology:DOID:13269); liver disease (Disease Ontology:DOID:409)", "pathway": " (mmu:12892); (R-MMU-189451)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "12862310;15482256;23576753;23806337;30084848;31616917;34428180;35527013;37453647;8159699;8407975", "class_list": "", "function": "A novel ENU-induced Cpox mutation causes microcytic hypochromic anemia in mice., [RefSeq, PubMed]; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQ36;Q8VD08", "ec_number_list": [ { "id": "1.3.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.3", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0005391 P-type sodium:potassium-exchanging transporter activity;GO:0005212 structural constituent of eye lens;GO:0004109 coproporphyrinogen oxidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:0010288 response to lead ion;GO:0006813 potassium ion transport;GO:0006814 sodium ion transport;GO:0051597 response to methylmercury", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P36552-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UMU9-1", "uniprot_id": [ { "id": "HDGR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UMU9", "type": "external" } ], "mass": 74291.0, "length": 669, "protein_name": "Hepatoma-derived growth factor-related protein 2", "gene_name": "Hdgfl2", "organism": "Mouse", "refseq_name": "hepatoma-derived growth factor-related protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001291713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291713", "type": "external" } ], "gene_names_uniprotkb": "Hdgfl2; Hdgfrp2", "gene_names_refseq": "HRP-2; Hdgfl2; Hdgfrp2", "protein_names_uniprotkb": "Hepatoma-derived growth factor-related protein 2; HRP-2", "protein_names_refseq": "hepatoma-derived growth factor, related protein 2; hepatoma-derived growth factor-related protein 2 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:15193)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "15345747;17242355;17622165;19131326;19144319;21183079;22212508;23042676;25689719;26367869;32459350;33477970;37507081;9299445", "class_list": "", "function": "Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (By similarity). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (By similarity). Involved in cellular growth control, through the regulation of cyclin D1 expression (By similarity). Associates with chromatin (PubMed:22212508)., [UniProtKB, PubMed, UniProtKB, PubMed]; Binds to condensed chromatin in mitotic cells., [UniProtKB, PubMed]; Binds to non-condensed chromatin in the presence of HDGF., [UniProtKB, PubMed]; HRP-2 can promote hepatocellular carcinoma cells growth in vitro and xenograft tumors in vivo., [RefSeq, PubMed]; HRP2-DPF3a-BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription., [RefSeq, PubMed]; The results show that HRP2 plays a role in HIV-1 integration when LEDGF/p75 is absent., [RefSeq, PubMed]; The role of HRP2 protein in cardiac development Publication Status: Online-Only, [RefSeq, PubMed]; Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6CHX5;O35540;Q3UIH6;Q99L92", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0061628 histone H3K27me3 reader activity;GO:0062072 histone H3K9me2/3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling;GO:0030307 positive regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q3UMU9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGP1-1", "uniprot_id": [ { "id": "H2B1K_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CGP1", "type": "external" } ], "mass": 13920.0, "length": 126, "protein_name": "Histone H2B type 1-K", "gene_name": "H2bc12", "organism": "Mouse", "refseq_name": "histone H2B type 1-K", "refseq_ac": [ { "id": "NP_783596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783596", "type": "external" } ], "gene_names_uniprotkb": "H2bc12; Hist1h2bk", "gene_names_refseq": "H2bc12; Hist1h2bk", "protein_names_uniprotkb": "Histone H2B type 1-K", "protein_names_refseq": "histone 1, H2bk; histone H2B type 1-K; histone cluster 1, H2bk", "tax_id": 10090, "disease": "", "pathway": " (mmu:319184); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214847); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-606279); (R-MMU-69473); (R-MMU-8866654); (R-MMU-8936459); (R-MMU-9018519); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 21, "publication_count": 12, "publication_id_list": "12408966;15197225;16039583;20647423;21925322;22389435;24681537;27105115;30154464;31645732;32822587;33300544", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000786 nucleosome", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8CGP1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZQ8-2", "uniprot_id": [ { "id": "H2AY_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZQ8", "type": "external" } ], "mass": 39290.0, "length": 369, "protein_name": "Core histone macro-H2A.1", "gene_name": "Macroh2a1", "organism": "Mouse", "refseq_name": "core histone macro-H2A.1 isoform 2", "refseq_ac": [ { "id": "NP_001152985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152985", "type": "external" } ], "gene_names_uniprotkb": "Macroh2a1; H2afy", "gene_names_refseq": "H2AF12M; H2afy; Macroh2a1; mH2a1", "protein_names_uniprotkb": "Core histone macro-H2A.1; H2A.y; H2A/y; Histone macroH2A1; mH2A1", "protein_names_refseq": "H2A histone family, member Y; H2A.y; H2A/y; MACROH2A1.2; core histone macro-H2A.1 isoform 2; core histone macro-H2A.1; histone macroH2A1", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908)", "pathway": " (mmu:26914)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10471737;11262398;12183056;15564378;16107708;19144319;21183079;23022728;23806337;26740625;28991266;29187734;30084848;34887560;36288343;37605008;37926763;39189450;39627609;9634239", "class_list": "", "function": "Deficiency of histone variant macroH2A1.1 is associated with sexually dimorphic obesity in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Histone variant macroH2A1 regulates synchronous firing of replication origins in the inactive X chromosome., [RefSeq, PubMed]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015]., [RefSeq]; In contrast to isoform 1, does not bind poly-ADP-ribose (By similarity). Represses SOD3 gene expression (PubMed:23022728)., [UniProtKB, PubMed, UniProtKB]; Isoform that specifically binds poly-ADP-ribose and O-acetyl-ADP-ribose and plays a key role in NAD(+) metabolism (PubMed:28991266, PubMed:34887560). Able to bind to the ends of poly-ADP-ribose chains created by PARP1 and cap them (PubMed:28991266). This prevents PARP1 from further addition of ADP-ribose and thus limits the consumption of nuclear NAD(+), allowing the cell to maintain proper NAD(+) levels in both the nucleus and the mitochondria to promote proper mitochondrial respiration (PubMed:28991266). Increases the expression of genes involved in redox metabolism, including SOD3 (PubMed:23022728)., [UniProtKB, PubMed, PubMed, PubMed]; MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping., [RefSeq, PubMed]; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription (By similarity). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By similarity). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (By similarity). DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Involved in stable X chromosome inactivation (By similarity). Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes (By similarity). Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin (PubMed:16107708)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91VZ2;Q9QZQ7", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005813 centrosome;GO:0000793 condensed chromosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0019216 regulation of lipid metabolic process;GO:1902884 positive regulation of response to oxidative stress;GO:0045815 transcription initiation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9QZQ8-2", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61658-1", "uniprot_id": [ { "id": "HESX1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61658", "type": "external" } ], "mass": 21504.0, "length": 185, "protein_name": "Homeobox expressed in ES cells 1", "gene_name": "Hesx1", "organism": "Mouse", "refseq_name": "homeobox expressed in ES cells 1", "refseq_ac": [ { "id": "NP_034550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034550", "type": "external" } ], "gene_names_uniprotkb": "Hesx1; Hes-1; Rpx", "gene_names_refseq": "HES-1; Hesx1; Rpx", "protein_names_uniprotkb": "Homeobox expressed in ES cells 1; Anterior-restricted homeobox protein; Homeobox protein ANF; Rathke pouch homeo box", "protein_names_refseq": "anterior-restricted homeobox protein; homeo box gene expressed in ES cells; homeobox expressed in ES cells 1; homeobox protein ANF; rathke pouch homeo box", "tax_id": 10090, "disease": "septooptic dysplasia (Disease Ontology:DOID:0060857); hypopituitarism (Disease Ontology:DOID:9406)", "pathway": " (mmu:15209)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1360650;7876132;8565852;9620767", "class_list": "", "function": "Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61047;Q8C477", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0042803 protein homodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0030878 thyroid gland development;GO:0043584 nose development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q61658-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54879-1", "uniprot_id": [ { "id": "HMGB3_MOUSE", "url": "https://www.uniprot.org/uniprot/O54879", "type": "external" } ], "mass": 23010.0, "length": 200, "protein_name": "High mobility group protein B3", "gene_name": "Hmgb3", "organism": "Mouse", "refseq_name": "high mobility group protein B3 isoform 1", "refseq_ac": [ { "id": "NP_001280552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001280552", "type": "external" } ], "gene_names_uniprotkb": "Hmgb3; Hmg2a; Hmg4", "gene_names_refseq": "Hmg2a; Hmg4; Hmgb3", "protein_names_uniprotkb": "High mobility group protein B3; HMG-2a; HMG-4; High mobility group protein 2a; High mobility group protein 4", "protein_names_refseq": "high mobility group protein 2a; high mobility group protein 4; high mobility group protein B3 isoform 1; high mobility group protein B3; high mobilty group protein 2A", "tax_id": 10090, "disease": "syndromic microphthalmia 13 (Disease Ontology:DOID:0111811)", "pathway": " (mmu:15354)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;12082634;12714519;15358624;16945912;19890330;21750661;30081728;33725478;34428180;35984892;9598312", "class_list": "", "function": "Hmgb3 may play an important role during embryo implantation and decidualization. Pleiotropin is a downstream target of Hmgb3 in the differentiation of uterine stromal cells., [RefSeq, PubMed]; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference for non-canonical DNA structures such as single-stranded DNA. Can bend DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (PubMed:19890330). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (PubMed:12714519, PubMed:15358624, PubMed:16945912)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Overexpression of the HMGA2 gene in transgenic mice leads to the onset of mixed growth hormone/prolactin cell pituitary adenomas. Erratum:[Oncogene. 2023 Jan;42(5):406. doi: 10.1038/s41388-022-02535-z. PMID: 36544045], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0000400 four-way junction DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045087 innate immune response;GO:0045638 negative regulation of myeloid cell differentiation;GO:0032392 DNA geometric change;GO:0045578 negative regulation of B cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O54879-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58406-1", "uniprot_id": [ { "id": "HRH3_MOUSE", "url": "https://www.uniprot.org/uniprot/P58406", "type": "external" } ], "mass": 48541.0, "length": 445, "protein_name": "Histamine H3 receptor", "gene_name": "Hrh3", "organism": "Mouse", "refseq_name": "histamine H3 receptor isoform 1", "refseq_ac": [ { "id": "NP_598610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598610", "type": "external" } ], "gene_names_uniprotkb": "Hrh3", "gene_names_refseq": "Eae8; H3R; HH3R; Hrh3", "protein_names_uniprotkb": "Histamine H3 receptor; H3R; HH3R", "protein_names_refseq": "experimental allergic encephalomyelitis susceptibility 8; histamine H3 receptor isoform 1; histamine H3 receptor", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); amnestic disorder (Disease Ontology:DOID:10914); sciatic neuropathy (Disease Ontology:DOID:11446); status epilepticus (Disease Ontology:DOID:1824); hyperglycemia (Disease Ontology:DOID:4195); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:99296); (R-MMU-390650)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12488429;21183079;21750661;25428506;30084848;36871761", "class_list": "", "function": "The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The histamine H3 receptor modulates dopamine D2 receptor-dependent signaling pathways and mouse behaviors., [RefSeq, PubMed]; These results suggest that neuronal histamine is a mediator of body-weight homeostasis and that neuronal histamine functions through H3 receptors in mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030594 neurotransmitter receptor activity;GO:0004969 histamine receptor activity;GO:1901363 heterocyclic compound binding;GO:0043176 amine binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0046058 cAMP metabolic process;GO:0007194 negative regulation of adenylate cyclase activity;GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007612 learning", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P58406-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88703-1", "uniprot_id": [ { "id": "HCN2_MOUSE", "url": "https://www.uniprot.org/uniprot/O88703", "type": "external" } ], "mass": 94722.0, "length": 863, "protein_name": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2", "gene_name": "Hcn2", "organism": "Mouse", "refseq_name": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2", "refseq_ac": [ { "id": "NP_032252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032252", "type": "external" } ], "gene_names_uniprotkb": "Hcn2; Bcng2; Hac1", "gene_names_refseq": "BCNG2; HAC1; Hcn2; trls", "protein_names_uniprotkb": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2; BCNG-2; Brain cyclic nucleotide-gated channel 2; HAC-1; Hyperpolarization-activated cation channel 1", "protein_names_refseq": "BCNG-2; HAC-1; brain cyclic nucleotide-gated channel 2; hyperpolarization-activated cation channel 1; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2", "tax_id": 10090, "disease": "familial febrile seizures 2 (Disease Ontology:DOID:0111310); dermatitis (Disease Ontology:DOID:2723); meningitis (Disease Ontology:DOID:9471)", "pathway": " (mmu:15166); (R-MMU-1296061)", "pathway_count": 2, "publication_count": 36, "publication_id_list": "10962006;11096117;11420311;11459060;11553787;11741901;12034718;12193608;12514127;12928435;12968185;17178405;17562314;18367452;19525958;21183079;21347269;21903816;22550182;22645316;23103389;24129315;27568927;31219806;33240105;33300544;34948328;35820727;35984892;36538279;37762124;38287019;40021952;40885482;9630217;9634236", "class_list": "", "function": "HCN2 Channels in the Ventral Hippocampal CA1 Regulate Nociceptive Hypersensitivity in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10962006, PubMed:11096117, PubMed:11459060, PubMed:11741901, PubMed:12034718, PubMed:12193608, PubMed:12968185, PubMed:17562314, PubMed:21347269, PubMed:21903816, PubMed:23103389). Can also transport ammonium in the distal nephron (By similarity). Involved in the initiation of neuropathic pain in sensory neurons (PubMed:21903816)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Thalamocortical Circuit Controls Neuropathic Pain via Up-regulation of HCN2 in the Ventral Posterolateral Thalamus., [RefSeq, PubMed]; The Role of Prostaglandin E1 as a Pain Mediator through Facilitation of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 via the EP2 Receptor in Trigeminal Ganglion Neurons of Mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 24, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "O70506", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0030165 PDZ domain binding;GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0071320 cellular response to cAMP;GO:0035725 sodium ion transmembrane transport;GO:0009410 response to xenobiotic stimulus;GO:1904045 cellular response to aldosterone", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "O88703-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88704-1", "uniprot_id": [ { "id": "HCN1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88704", "type": "external" } ], "mass": 102432.0, "length": 910, "protein_name": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1", "gene_name": "Hcn1", "organism": "Mouse", "refseq_name": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1", "refseq_ac": [ { "id": "NP_034538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034538", "type": "external" } ], "gene_names_uniprotkb": "Hcn1; Bcng1; Hac2", "gene_names_refseq": "Bcng1; C630013B14Rik; HAC2; Hcn1", "protein_names_uniprotkb": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1; BCNG-1; Brain cyclic nucleotide-gated channel 1; HAC-2; Hyperpolarization-activated cation channel 2", "protein_names_refseq": "BCNG-1; HAC-2; brain cyclic nucleotide-gated channel 1; hyperpolarization-activated cation channel 2; hyperpolarization-activated, cyclic nucleotide-gated K+ 1; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 24 (Disease Ontology:DOID:0080429); complex cortical dysplasia with other brain malformations (Disease Ontology:DOID:0090131); generalized epilepsy with febrile seizures plus 10 (Disease Ontology:DOID:0111296); sick sinus syndrome (Disease Ontology:DOID:13884); status epilepticus (Disease Ontology:DOID:1824); childhood absence epilepsy (Disease Ontology:DOID:1825); anxiety disorder (Disease Ontology:DOID:2030); mood disorder (Disease Ontology:DOID:3324); temporal lobe epilepsy (Disease Ontology:DOID:3328); meningitis (Disease Ontology:DOID:9471)", "pathway": " (mmu:15165); (R-MMU-1296061)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;11420311;11459060;11675786;12034718;12089064;12351622;14651847;22006928;22645316;24218458;26269648;32848054;33300544;34678516;35822049;36089097;36813574;37828378;40885482;9405696;9630217;9634236", "class_list": "", "function": "Altered EEG power spectrum, but not sleep-wake architecture, in HCN1 knockout mice., [RefSeq, PubMed]; Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions (PubMed:12034718, PubMed:22006928, PubMed:9630217). Exhibits weak selectivity for potassium over sodium ions (PubMed:11459060). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:11459060). Participates in cerebellar mechanisms of motor learning (PubMed:14651847). May mediate responses to sour stimuli (PubMed:11675786)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Retinal Dysfunction in a Mouse Model of HCN1 Genetic Epilepsy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 10, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 10, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "O54899;Q9D613", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0042802 identical protein binding;GO:0005248 voltage-gated sodium channel activity;GO:0005222 intracellularly cAMP-activated cation channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0019228 neuronal action potential;GO:0042391 regulation of membrane potential;GO:0051289 protein homotetramerization;GO:0051592 response to calcium ion;GO:0071320 cellular response to cAMP", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "O88704-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52927-1", "uniprot_id": [ { "id": "HMGA2_MOUSE", "url": "https://www.uniprot.org/uniprot/P52927", "type": "external" } ], "mass": 11819.0, "length": 108, "protein_name": "High mobility group protein HMGI-C", "gene_name": "Hmga2", "organism": "Mouse", "refseq_name": "high mobility group protein HMGI-C isoform 2", "refseq_ac": [ { "id": "NP_001334099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334099", "type": "external" } ], "gene_names_uniprotkb": "Hmga2; Hmgic", "gene_names_refseq": "9430083A20Rik; HMGI-C; Hmga2; Hmgic; pg; pygmy", "protein_names_uniprotkb": "High mobility group protein HMGI-C; High mobility group AT-hook protein 2", "protein_names_refseq": "high mobility group AT-hook protein 2; high mobility group protein HMGI-C isoform 2; high mobility group protein HMGI-C; high mobility group protein I", "tax_id": 10090, "disease": "leiomyoma (Disease Ontology:DOID:127); Silver-Russell syndrome (Disease Ontology:DOID:14681); ovarian cancer (Disease Ontology:DOID:2394); lipoma (Disease Ontology:DOID:3315); hamartoma (Disease Ontology:DOID:3462)", "pathway": " (mmu:15364); (R-MMU-2559584)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "14668482;1762909;19131326;21183079;21540332;22645316;27446912;28135057;38516887;38811851;39051068;8566786;8918814", "class_list": "", "function": "Characterization of HMGA2 variants expands the spectrum of Silver-Russell syndrome. Publication Status: Online-Only, [RefSeq, PubMed]; Chromatin modifier Hmga2 promotes adult hematopoietic stem cell function and blood regeneration in stress conditions., [RefSeq, PubMed]; Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (PubMed:27446912). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; [Hmga2 knockdown enhances osteogenic differentiation of adipose-derived mesenchymal stem cells and accelerates bone defect healing in mice]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQW0", "ec_number_list": [], "go_molecular_function": "GO:0051575 5'-deoxyribose-5-phosphate lyase activity;GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0008301 DNA binding, bending;GO:0019899 enzyme binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0032993 protein-DNA complex;GO:0000228 nuclear chromosome", "go_biological_process": "GO:0060123 regulation of growth hormone secretion;GO:2000648 positive regulation of stem cell proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P52927-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00493-1", "uniprot_id": [ { "id": "HPRT_MOUSE", "url": "https://www.uniprot.org/uniprot/P00493", "type": "external" } ], "mass": 24570.0, "length": 218, "protein_name": "Hypoxanthine-guanine phosphoribosyltransferase", "gene_name": "Hprt1", "organism": "Mouse", "refseq_name": "hypoxanthine-guanine phosphoribosyltransferase", "refseq_ac": [ { "id": "NP_038584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038584", "type": "external" } ], "gene_names_uniprotkb": "Hprt1; Hprt", "gene_names_refseq": "HPGRT; Hprt1; Hprt", "protein_names_uniprotkb": "Hypoxanthine-guanine phosphoribosyltransferase; 2.4.2.8; HGPRTase; HGPRT; HPRT B", "protein_names_refseq": "HGPRTase; HGPRT; HPRT A; HPRT B; hypoxanthine guanine phosphoribosyl transferase 1; hypoxanthine-guanine phosphoribosyltransferase", "tax_id": 10090, "disease": "HRPT-related hyperuricemia (Disease Ontology:DOID:0112127); Lesch-Nyhan syndrome (Disease Ontology:DOID:1919); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:15452); (R-MMU-74217); (R-MMU-9748787)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "23806337;28528544;31219806;33300544;6294614;6326107", "class_list": "glycogene", "function": "Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity)., [UniProtKB]; The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 22, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q545Y2", "ec_number_list": [ { "id": "2.4.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.8", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0004422 hypoxanthine phosphoribosyltransferase activity;GO:0052657 guanine phosphoribosyltransferase activity", "go_cellular_component": "GO:0097229 sperm end piece;GO:0097227 sperm annulus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0097228 sperm principal piece", "go_biological_process": "GO:0007626 locomotory behavior;GO:0051289 protein homotetramerization;GO:0001975 response to amphetamine;GO:0046040 IMP metabolic process;GO:0043103 hypoxanthine salvage", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P00493-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60793-1", "uniprot_id": [ { "id": "KLF4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60793", "type": "external" } ], "mass": 51880.0, "length": 483, "protein_name": "Krueppel-like factor 4", "gene_name": "Klf4", "organism": "Mouse", "refseq_name": "Krueppel-like factor 4", "refseq_ac": [ { "id": "NP_034767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034767", "type": "external" } ], "gene_names_uniprotkb": "Klf4; Ezf; Gklf; Zie", "gene_names_refseq": "EZF; Gklf; Klf4; Zie", "protein_names_uniprotkb": "Krueppel-like factor 4; Epithelial zinc finger protein EZF; Gut-enriched krueppel-like factor", "protein_names_refseq": "Krueppel-like factor 4; Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF); Kruppel-like factor 4 (gut); epithelial zinc finger protein EZF; gut-enriched krueppel-like factor", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:16600)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10431239;10556311;12441126;15358627;16904174;16954384;17060454;19816951;20071344;21750661;22608532;23762260;24161396;29593216;30084848;35922041;36852467;39986490;40128797;8702718;8940147;9218496;9428642", "class_list": "glycogene", "function": "Paper describes that expression of Klf4 is developmentally regulated and is decreased in a mouse model of intestinal tumorigenesis., [RefSeq, PubMed]; Paper describes the first identification of the mouse Kruppel-like factor 4 or KLF4 (gut) that appears to be an inhibitor of cell growth., [RefSeq, PubMed]; Paper identifies two potent nuclear localization signals (NLSs) in Klf4 that are similar to those of two other KLFs: Klf1 and Klf2., [RefSeq, PubMed]; Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216, PubMed:39986490). Binds to the promoter region of its own gene and can activate its own transcription (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216). Regulates the expression of key transcription factors during embryonic development (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216). Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216). Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "P70421;Q3U2D6;Q3URS6;Q78K30;Q9R255", "ec_number_list": [], "go_molecular_function": "GO:0001010 RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0009913 epidermal cell differentiation;GO:0014740 negative regulation of muscle hyperplasia;GO:0048679 regulation of axon regeneration;GO:1904998 negative regulation of leukocyte adhesion to arterial endothelial cell", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q60793-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000001001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921E6-1", "uniprot_id": [ { "id": "EED_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921E6", "type": "external" } ], "mass": 50198.0, "length": 441, "protein_name": "Polycomb protein EED", "gene_name": "Eed", "organism": "Mouse", "refseq_name": "polycomb protein EED", "refseq_ac": [ { "id": "NP_068676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068676", "type": "external" } ], "gene_names_uniprotkb": "Eed", "gene_names_refseq": "Eed; l(7)5Rn; l7Rn5; lusk", "protein_names_uniprotkb": "Polycomb protein EED", "protein_names_refseq": "lethal, Chr 7, Rinchik 5; polycomb protein EED", "tax_id": 10090, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (mmu:13626); (R-MMU-212300); (R-MMU-2559580); (R-MMU-3214841); (R-MMU-8943724); (R-MMU-8953750); (R-MMU-9764725); (R-MMU-9909649)", "pathway_count": 8, "publication_count": 29, "publication_id_list": "11479595;12123576;12370779;12627233;12649488;12689588;14671313;14752160;15516932;15684044;15916951;16007070;16224021;16415857;16618801;17259173;17937919;17997413;18201968;19026780;19144319;20144788;21183079;21750661;23970558;34428180;8805699;9234727;9742080", "class_list": "", "function": "Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Required for stable maintenance of XCI in both embryonic and extraembryonic tissues. May prevent transcriptional activation of facultative heterochromatin during differentiation. Required for development of secondary trophoblast giant cells during placental development. 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Cfap44; D16Ertd642e; Gm1750; Wdr52", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 44", "protein_names_refseq": "WD repeat domain 52; cilia- and flagella-associated protein 44", "tax_id": 10090, "disease": "spermatogenic failure 20 (Disease Ontology:DOID:0070166)", "pathway": " (mmu:212517)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;28552195;29449551", "class_list": "", "function": "Biallelic mutations in either CFAP43 or CFAP44 can cause sperm flagellar abnormalities and impair sperm motility., [RefSeq, PubMed]; Flagellar protein involved in sperm flagellum axoneme organization and function., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008233 peptidase activity", "go_cellular_component": "GO:0031514 motile cilium;GO:0005930 axoneme", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0000902 cell morphogenesis;GO:0000226 microtubule cytoskeleton organization;GO:0044782 cilium organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9Q5M6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U3C9-1", "uniprot_id": [ { "id": "GSE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U3C9", "type": "external" } ], "mass": 136228.0, "length": 1213, "protein_name": "Genetic suppressor element 1", "gene_name": "Gse1", "organism": "Mouse", "refseq_name": "genetic suppressor element 1 isoform 2", "refseq_ac": [ { "id": "NP_001139368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139368", "type": "external" } ], "gene_names_uniprotkb": "Gse1; Kiaa0182", "gene_names_refseq": "2210013I18Rik; Gse1; mKIAA0182", "protein_names_uniprotkb": "Genetic suppressor element 1", "protein_names_refseq": "genetic suppressor element 1 isoform 2", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534)", "pathway": " (mmu:382034)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;16169686;21183079;21750661;25428506;27802388;30059200;30084848;34428180;34678516;35820727;36852467;37019373;40885482;8170981", "class_list": "", "function": "Gse1, a component of the CoREST complex, is required for placenta development in the mouse., [RefSeq, PubMed]; Some mKIAA genes are apparently relevant to retinoic acid-induced neurite outgrowth. (mKIAA gene), [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q3UWZ5;Q80U67;Q80XR0;Q8CCF2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0001890 placenta development;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q3U3C9-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ULW8-1", "uniprot_id": [ { "id": "PARP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3ULW8", "type": "external" } ], "mass": 59949.0, "length": 533, "protein_name": "Protein mono-ADP-ribosyltransferase PARP3", "gene_name": "Parp3", "organism": "Mouse", "refseq_name": "protein mono-ADP-ribosyltransferase PARP3 isoform 1", "refseq_ac": [ { "id": "NP_001298079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298079", "type": "external" } ], "gene_names_uniprotkb": "Parp3; Adprt3", "gene_names_refseq": "A930002C11Rik; ADPRT-3; ARTD3; Adprt3; Adprtl3; PARP-3; Parp3; pADPRT-3", "protein_names_uniprotkb": "Protein mono-ADP-ribosyltransferase PARP3; 2.4.2.-; ADP-ribosyltransferase diphtheria toxin-like 3; ADPRT-3; ARTD3; DNA ADP-ribosyltransferase PARP3; NAD(+) ADP-ribosyltransferase 3; PARP-3; Poly [ADP-ribose] polymerase 3; Poly[ADP-ribose] synthase 3; pADPRT-3", "protein_names_refseq": "A DP-ribosyltransferase (NAD+; ADP-ribosyltransferase (NAD+, poly (ADP-ribose polymerase)-like 3; ADP-ribosyltransferase diphtheria toxin-like 3; DNA ADP-ribosyltransferase PARP3; NAD(+) ADP-ribosyltransferase 3; NAD+ ADP-ribosyltransferase 3; Poly[ADP-ribose] synthetase-3; poly (ADP-ribose polymerase)-like 3; poly [ADP-ribose] polymerase 3; poly[ADP-ribose] synthase 3; protein mono-ADP-ribosyltransferase PARP3 isoform 1; protein mono-ADP-ribosyltransferase PARP3", "tax_id": 10090, "disease": "", "pathway": " (mmu:235587)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12448766;21211721;21270334;21750661;22645316;24598253;26000965;30213852;36870456", "class_list": "", "function": "Fall of PARP3 restrains Lgr5[+] intestinal stem cells proliferation and mucosal renovation in intestinal aging., [RefSeq, PubMed]; Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage (PubMed:21270334, PubMed:24598253). Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins (By similarity). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (By similarity). Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as histone H2B, XRCC5 and XRCC6 (By similarity). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity). Involved in single-strand break repair by catalyzing mono-ADP-ribosylation of histone H2B on 'Glu-2' (H2BE2ADPr) of nucleosomes containing nicked DNA (By similarity). Cooperates with the XRCC5-XRCC6 (Ku80-Ku70) heterodimer to limit end-resection thereby promoting accurate NHEJ (By similarity). Suppresses G-quadruplex (G4) structures in response to DNA damage (By similarity). Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks (PubMed:21270334). Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (By similarity). May link the DNA damage surveillance network to the mitotic fidelity checkpoint (By similarity). Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin (PubMed:26000965). In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; PARP-3 has a role in chromosomal DNA double-strand break repair., [RefSeq, PubMed]; These data indicate that Parp3 and Parp1 promote rearrangements with distinct phenotypes., [RefSeq, PubMed]; We cloned and sequenced the cDNAs of the mouse PARP-3 (Adprt3) gene encoding poly(ADP-ribose) polymerase 3 and of the closely linked U3-55k gene coding for the U3 small nucleolar ribonucleoprotein complex-associated 55-kilodalton protein., [RefSeq, PubMed]; We show that Poly(ADP)ribose polymerase 3 (Parp3), an enzyme recently implicated in DNA repair, contributes to antibody diversification by negatively regulating class switch recombination without affecting somatic hypermutation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1L1SRP6;E9PX17;E9Q992;Q3UGL7;Q8BHN6;Q8BXU2;Q8CFB8;Q91YR6", "ec_number_list": [ { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" } ], "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:0140294 NAD DNA ADP-ribosyltransferase activity;GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005813 centrosome;GO:0045171 intercellular bridge;GO:0016604 nuclear body", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0070213 protein auto-ADP-ribosylation;GO:0000723 telomere maintenance;GO:0006302 double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q3ULW8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "H3BK29-1", "uniprot_id": [ { "id": "H3BK29_MOUSE", "url": "https://www.uniprot.org/uniprot/H3BK29", "type": "external" } ], "mass": 102849.0, "length": 913, "protein_name": "Vomeronasal 2, receptor 6", "gene_name": "Vmn2r6", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Vmn2r6; Vmn2r4", "gene_names_refseq": "", "protein_names_uniprotkb": "Vomeronasal 2, receptor 6", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "H3BK29-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70293-1", "uniprot_id": [ { "id": "GRK6_MOUSE", "url": "https://www.uniprot.org/uniprot/O70293", "type": "external" } ], "mass": 65979.0, "length": 576, "protein_name": "G protein-coupled receptor kinase 6", "gene_name": "Grk6", "organism": "Mouse", "refseq_name": "G protein-coupled receptor kinase 6 isoform a", "refseq_ac": [ { "id": "NP_001033107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033107", "type": "external" } ], "gene_names_uniprotkb": "Grk6; Gprk6", "gene_names_refseq": "Gprk6; Grk6", "protein_names_uniprotkb": "G protein-coupled receptor kinase 6; 2.7.11.16; G protein-coupled receptor kinase GRK6", "protein_names_refseq": "G protein-coupled receptor kinase 6 isoform a; g protein-coupled receptor kinase GRK6", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); opiate dependence (Disease Ontology:DOID:2559); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (mmu:26385); (R-MMU-418555)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10506199;12032308;12718862;14634128;21183079;21750661;26886170;32486261;34428180;36030052;38883814", "class_list": "", "function": "Deficiency causes defective lymphocyte chemotaxis, [RefSeq, PubMed]; G protein-coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin., [RefSeq, PubMed]; Role of GRK6 in the Regulation of Platelet Activation through Selective G Protein-Coupled Receptor (GPCR) Desensitization. Publication Status: Online-Only, [RefSeq, PubMed]; Specifically phosphorylates the activated forms of G protein-coupled receptors (PubMed:12032308, PubMed:12718862, PubMed:14634128, PubMed:26886170, PubMed:38883814). Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:12032308, PubMed:12718862, PubMed:14634128, PubMed:26886170, PubMed:38883814). Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G protein-coupled receptor: LRP6 during Wnt signaling (in vitro) (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70294;O70295;Q6DI67", "ec_number_list": [ { "id": "2.7.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.16", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.15", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0004703 G protein-coupled receptor kinase activity;GO:0047696 beta-adrenergic receptor kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0016055 Wnt signaling pathway;GO:0009966 regulation of signal transduction;GO:0002029 desensitization of G protein-coupled receptor signaling pathway;GO:0010360 negative regulation of anion channel activity", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O70293-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q032-1", "uniprot_id": [ { "id": "E9Q032_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q032", "type": "external" } ], "mass": 15678.0, "length": 133, "protein_name": "Predicted gene 3512", "gene_name": "Gm3512", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm3512", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene 3512", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q032-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PAV2-1", "uniprot_id": [ { "id": "HERC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PAV2", "type": "external" } ], "mass": 118412.0, "length": 1057, "protein_name": "Probable E3 ubiquitin-protein ligase HERC4", "gene_name": "Herc4", "organism": "Mouse", "refseq_name": "probable E3 ubiquitin-protein ligase HERC4 isoform 2", "refseq_ac": [ { "id": "NP_080377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080377", "type": "external" } ], "gene_names_uniprotkb": "Herc4", "gene_names_refseq": "1700056O17Rik; 4921531D01Rik; 9530080M15Rik; Herc4; mKIAA1593", "protein_names_uniprotkb": "Probable E3 ubiquitin-protein ligase HERC4; 2.3.2.26; HECT domain and RCC1-like domain-containing protein 4; HECT-type E3 ubiquitin transferase HERC4", "protein_names_refseq": "HECT domain and RCC1-like domain-containing protein 4; HECT-type E3 ubiquitin transferase HERC4; probable E3 ubiquitin-protein ligase HERC4 isoform 2; probable E3 ubiquitin-protein ligase HERC4", "tax_id": 10090, "disease": "", "pathway": " (mmu:67345); (R-MMU-983168)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "17967448;18250455;19819847;21750661;25428506;25605945;26740625;26825710;34428180", "class_list": "", "function": "HERC4 plays an important role in Multiple myeloma progression., [RefSeq, PubMed]; Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates., [UniProtKB, PubMed]; The E3 ubiquitin ligase Herc4, though ubiquitously expressed in all tissues, is most highly expressed in the testis, specifically during spermiogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UL34;Q3UPX2;Q810A0;Q811C9;Q8R315;Q9D797", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0001650 fibrillar center", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0045879 negative regulation of smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6PAV2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q912-1", "uniprot_id": [ { "id": "GDS1_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q912", "type": "external" } ], "mass": 66076.0, "length": 607, "protein_name": "Rap1 GTPase-GDP dissociation stimulator 1", "gene_name": "Rap1gds1", "organism": "Mouse", "refseq_name": "rap1 GTPase-GDP dissociation stimulator 1 isoform c", "refseq_ac": [ { "id": "NP_001273688", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273688", "type": "external" } ], "gene_names_uniprotkb": "Rap1gds1", "gene_names_refseq": "GDS1; Rap1gds1", "protein_names_uniprotkb": "Rap1 GTPase-GDP dissociation stimulator 1", "protein_names_refseq": "rap1 GTPase-GDP dissociation stimulator 1 isoform c; rap1 GTPase-GDP dissociation stimulator 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:229877)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;23640485;29145128;29921611;37061660;40684658", "class_list": "", "function": "Acts as a GEF (guanine nucleotide exchange factor) for prenylated RHOA. Acts as a GEF for RHOC. Chaperones the downstream trafficking and/or processing of small newly prenylated GTPases. Escorts RAC1 to the nucleus., [UniProtKB, UniProtKB]; Acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP. Additionally, appears to chaperone the processing and/or trafficking of small GTPases containing a C-terminal polybasic region independently of GEF activity. Targets include RAP1A/RAP1B, RHOA, RHOB, RHOC, RAC1 and KRAS. Regulates mitochondrial dynamics by controlling RHOT function to promote mitochondrial fission during high calcium conditions. Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake., [UniProtKB, UniProtKB]; Acts as a GEF (guanine nucleotide exchange factor) for unprenylated RHOA. Chaperones the entry and passage of small GTPases through the prenylation pathway. Recognizes the last amino acid in the GTPase C-terminal CAAX motif with a preference for 'Leu' over 'Met', indicating involvement in the geranylgeranylation pathway. May also recognize prenylated GTPases., [UniProtKB, UniProtKB]; Apoe(-/-) SmgGDS(+/-) mice showed significantly higher levels of oxidative stress, matrix metalloproteinases, and inflammatory cell migration in the ascending aorta compared with Apoe(-/-) mice. local delivery of the SmgGDS gene construct reversed the dilation of the ascending aorta in Apoe(-/-) SmgGDS(+/-) mice., [RefSeq, PubMed]; Simulated microgravity activates Cdc42 via Rap1GDS1 to promote vascular branch morphogenesis., [RefSeq, PubMed]; These results indicate that statins exert their pleiotropic effects through SmgGDS upregulation with a resultant Rac1 degradation and reduced oxidative stress in animals and humans., [RefSeq, PubMed]; Vimar/RAP1GDS1 promotes acceleration of brain aging after flies and mice reach middle age. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9Q6Q4;I6L967;Q3TA69;Q3TLU4;Q3TPS9;Q3TU36", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0030695 GTPase regulator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0031034 myosin filament assembly;GO:0043547 positive regulation of GTPase activity;GO:0003300 cardiac muscle hypertrophy;GO:0038166 angiotensin-activated signaling pathway;GO:0014829 vascular associated smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "E9Q912-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQB2-1", "uniprot_id": [ { "id": "Q9EQB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQB2", "type": "external" } ], "mass": 35331.0, "length": 313, "protein_name": "Olfactory receptor", "gene_name": "Or8c16", "organism": "Mouse", "refseq_name": "olfactory receptor 894", "refseq_ac": [ { "id": "NP_667079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_667079", "type": "external" } ], "gene_names_uniprotkb": "Or8c16; Olfr893; Olfr894", "gene_names_refseq": "MOR170-5; Olfr894; Or8c16", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PVTD-31898993-31899934; olfactory receptor 894; olfactory receptor MOR170-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:258868)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PYB6;E9PYB7", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9EQB2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZQ18-1", "uniprot_id": [ { "id": "EFR3B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZQ18", "type": "external" } ], "mass": 92406.0, "length": 817, "protein_name": "Protein EFR3 homolog B", "gene_name": "Efr3b", "organism": "Mouse", "refseq_name": "protein EFR3 homolog B", "refseq_ac": [ { "id": "NP_001075952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075952", "type": "external" } ], "gene_names_uniprotkb": "Efr3b; Kiaa0953", "gene_names_refseq": "C030014M07Rik; Efr3b; mKIAA0953", "protein_names_uniprotkb": "Protein EFR3 homolog B", "protein_names_refseq": "protein EFR3 homolog B", "tax_id": 10090, "disease": "", "pathway": " (mmu:668212)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;25380825;34428180;38190534", "class_list": "", "function": "Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, EFR3B probably acts as the membrane-anchoring component. Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Efr3b is essential for social recognition by modulating the excitability of CA2 pyramidal neurons., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RXT1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0019226 transmission of nerve impulse;GO:0035176 social behavior;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6ZQ18-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6A0A9-1", "uniprot_id": [ { "id": "F120A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6A0A9", "type": "external" } ], "mass": 121646.0, "length": 1112, "protein_name": "Constitutive coactivator of PPAR-gamma-like protein 1", "gene_name": "FAM120A", "organism": "Mouse", "refseq_name": "constitutive coactivator of PPAR-gamma-like protein 1", "refseq_ac": [ { "id": "NP_001028440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028440", "type": "external" } ], "gene_names_uniprotkb": "FAM120A; Kiaa0183; Ossa", "gene_names_refseq": "C9orf10; Fam120a; Ossa", "protein_names_uniprotkb": "Constitutive coactivator of PPAR-gamma-like protein 1; Oxidative stress-associated SRC activator; Protein FAM120A", "protein_names_refseq": "constitutive coactivator of PPAR-gamma-like protein 1; family with sequence similarity 120A; oxidative stress-associated Src activator", "tax_id": 10090, "disease": "", "pathway": " (mmu:218236)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;18413649;23806337;24129315;25428506;25605945;28135057;28528544;29187734;31219806;31289130;34428180;34887587;37453647;38339971;39627609;39927985", "class_list": "", "function": "C9orf10/Ossa regulates the bone metastasis of established lung adenocarcinoma cell subline H322L-BO4 in a mouse model., [RefSeq, PubMed]; Expression patterns suggest an accessory role of C9orf10 for Puralpha in a limited brain region in addition to other possible functions that have not yet been determined., [RefSeq, PubMed]; Membrane-associated scaffold protein that participates in multiple cellular processes, including oxidative stress-induced survival signaling, RNA trafficking and translational regulation, and the modulation of membrane signaling through its interaction with RNA-binding proteins and lipid raft-associated domains. Functions as a regulator of activation of several intracellular kinases, including SRC, FAK, and PI3K, following oxidative stress. Promotes RNA splicing and stability of lipogenic enzymes. Mechanistically, recruits the lipogenic transcription factor SREBP1 at active promoters, thereby bridging the newly transcribed lipogenic genes from RNA polymerase II to the SRSF1 and U1-70K-containing RNA-splicing machinery. Associates with key proteins of the NLRP3 inflammasome pathway and subsequently inhibits NLRP3 inflammasome activation (By similarity). Sequesters a subset of AGO2-bound mRNAs from miRNA-mediated silencing by binding to poly(G)-rich motifs in their 3'-UTR independently of the AGO2 binding site, likely by preventing recruitment of miRISC effectors (PubMed:31289130)., [UniProtKB, UniProtKB, PubMed]; Reporter assays suggest that the 3'-UTRs of several FAM120A-bound miRNA target genes are less sensitive to Ago2-mediated target repression than those of FAM120A-unbound miRNA targets and FAM120A modulates them via its G-rich target sites, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0PJK6;B3DFJ0;Q91Z16", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q6A0A9-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WS3-1", "uniprot_id": [ { "id": "FBLL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80WS3", "type": "external" } ], "mass": 33339.0, "length": 314, "protein_name": "RNA 2'-O-methyltransferase FBLL1", "gene_name": "Fbll1", "organism": "Mouse", "refseq_name": "RNA 2'-O-methyltransferase FBLL1", "refseq_ac": [ { "id": "NP_001004147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004147", "type": "external" } ], "gene_names_uniprotkb": "Fbll1", "gene_names_refseq": "Fbll1", "protein_names_uniprotkb": "RNA 2'-O-methyltransferase FBLL1; 2.1.1.-; Fibrillarin like 1", "protein_names_refseq": "RNA 2'-O-methyltransferase FBLL1; protein-glutamine methyltransferase; rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:237730)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "24129315;39570315;39627609", "class_list": "", "function": "S-adenosyl-L-methionine-dependent RNA methyltransferase that catalyzes 2'-hydroxyl ribose methylation in RNAs (PubMed:39570315). Functions as part of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes, where guide snoRNAs ensure methylation specificity through base pairing with RNA substrates (PubMed:39570315). Exhibits broad substrate specificity, methylating multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) depending on the guide snoRNA incorporated in the complex (PubMed:39570315). Specifically expressed in brain, it regulates the expression of GAP43 by stabilizing its mRNA through methylation and thereby plays an indirect role in neuronal differentiation (PubMed:39570315)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0008649 rRNA methyltransferase activity;GO:1990259 histone H2AQ104 methyltransferase activity;GO:0062105 RNA 2'-O-methyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0001650 fibrillar center;GO:0015030 Cajal body;GO:0031428 box C/D methylation guide snoRNP complex", "go_biological_process": "GO:0031167 rRNA methylation;GO:0048255 mRNA stabilization;GO:0001835 blastocyst hatching;GO:0000494 box C/D sno(s)RNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80WS3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16056-1", "uniprot_id": [ { "id": "MET_MOUSE", "url": "https://www.uniprot.org/uniprot/P16056", "type": "external" } ], "mass": 153549.0, "length": 1379, "protein_name": "Hepatocyte growth factor receptor", "gene_name": "Met", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Met", "gene_names_refseq": "", "protein_names_uniprotkb": "Hepatocyte growth factor receptor; 2.7.10.1; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; SF receptor; Scatter factor receptor; Tyrosine-protein kinase Met", "protein_names_refseq": "", "tax_id": 10090, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive nonsyndromic deafness 97 (Disease Ontology:DOID:0110539); prostate carcinoma (Disease Ontology:DOID:10286); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); sarcoma (Disease Ontology:DOID:1115); gestational diabetes (Disease Ontology:DOID:11714); autistic disorder (Disease Ontology:DOID:12849); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); arteriosclerosis (Disease Ontology:DOID:2349); ovarian cancer (Disease Ontology:DOID:2394); invasive ductal carcinoma (Disease Ontology:DOID:3008); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); papillary renal cell carcinoma (Disease Ontology:DOID:4465); large cell carcinoma (Disease Ontology:DOID:4552); cholangiocarcinoma (Disease Ontology:DOID:4947); pancreatitis (Disease Ontology:DOID:4989); gastrinoma (Disease Ontology:DOID:5577); hepatocellular carcinoma (Disease Ontology:DOID:684); periodontitis (Disease Ontology:DOID:824); liver benign neoplasm (Disease Ontology:DOID:916); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:17295); (R-MMU-1257604); (R-MMU-416550); (R-MMU-5673001); (R-MMU-6806942); (R-MMU-6807004); (R-MMU-6811558); (R-MMU-8851805); (R-MMU-8851907); (R-MMU-8865999); (R-MMU-8874081); (R-MMU-8875513); (R-MMU-8875555); (R-MMU-8875656); (R-MMU-8875791); (R-MMU-9734091)", "pathway_count": 16, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;11081636;11896575;15314156;16369487;21750661;2482828;26637977;26740625;2838789;30084848;30777867;31219806;34428180;35820727;35984892;37828378;7651534;8384622", "class_list": "", "function": "(Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells., [UniProtKB, PubMed]; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of neuronal precursors, angiogenesis and kidney formation. During skeletal muscle development, it is crucial for the migration of muscle progenitor cells and for the proliferation of secondary myoblasts (PubMed:30777867). In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Also promotes differentiation and proliferation of hematopoietic cells (By similarity). May regulate cortical bone osteogenesis (PubMed:26637977)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 6, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 5, "disease_count": 29, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "Q62125", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0071635 negative regulation of transforming growth factor beta production;GO:2001028 positive regulation of endothelial cell chemotaxis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001889 liver development;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P16056-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VG94-1", "uniprot_id": [ { "id": "Q8VG94_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VG94", "type": "external" } ], "mass": 34989.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or2n1b", "organism": "Mouse", "refseq_name": "olfactory receptor family 2 subfamily N member 1B", "refseq_ac": [ { "id": "NP_667042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_667042", "type": "external" } ], "gene_names_uniprotkb": "Or2n1b; Olfr133", "gene_names_refseq": "MOR256-6; Olfr133; Or2n1b", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PSCP-2597192-2598130; olfactory receptor 133; olfactory receptor MOR256-6; olfactory receptor family 2 subfamily N member 1B", "tax_id": 10090, "disease": "", "pathway": " (mmu:258828)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VG94-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08756-1", "uniprot_id": [ { "id": "HCD2_MOUSE", "url": "https://www.uniprot.org/uniprot/O08756", "type": "external" } ], "mass": 27419.0, "length": 261, "protein_name": "3-hydroxyacyl-CoA dehydrogenase type-2", "gene_name": "Hsd17b10", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hsd17b10; Erab; Hadh2", "gene_names_refseq": "", "protein_names_uniprotkb": "3-hydroxyacyl-CoA dehydrogenase type-2; 1.1.1.159; 1.1.1.178; 1.1.1.239; 1.1.1.35; 1.1.1.53; 1.1.1.62; 17-beta-estradiol 17-dehydrogenase; 2-methyl-3-hydroxybutyryl-CoA dehydrogenase; 3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)); 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase type II; 3alpha(or 20beta)-hydroxysteroid dehydrogenase; 7-alpha-hydroxysteroid dehydrogenase; Endoplasmic reticulum-associated amyloid beta-peptide-binding protein; MHBD; Mitochondrial RNase P protein 2; Mitochondrial ribonuclease P protein 2; Short chain dehydrogenase/reductase family 5C member 1; Short-chain type dehydrogenase/reductase XH98G2; Type II HADH", "protein_names_refseq": "", "tax_id": 10090, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); syndromic X-linked intellectual disability type 10 (Disease Ontology:DOID:0060810); Alzheimer's disease (Disease Ontology:DOID:10652); osteosarcoma (Disease Ontology:DOID:3347)", "pathway": " (R-MMU-70895); (R-MMU-9837999)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;20077426;20484733;21750661;23576753;23806337;34428180;35820727;37453647;37507081;39927985", "class_list": "", "function": "In addition to mitochondrial dehydrogenase activity, moonlights as a component of mitochondrial ribonuclease P, a complex that cleaves tRNA molecules in their 5'-ends. Together with TRMT10C/MRPP1, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity. The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; HSD17B10/MRPP2 acting as a non-catalytic subunit. The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly., [UniProtKB, UniProtKB]; Mitochondrial dehydrogenase involved in pathways of fatty acid, branched-chain amino acid and steroid metabolism (By similarity). Acts as (S)-3-hydroxyacyl-CoA dehydrogenase in mitochondrial fatty acid beta-oxidation, a major degradation pathway of fatty acids. Catalyzes the third step in the beta-oxidation cycle, namely the reversible conversion of (S)-3-hydroxyacyl-CoA to 3-ketoacyl-CoA. Preferentially accepts straight medium- and short-chain acyl-CoA substrates with highest efficiency for (3S)-hydroxybutanoyl-CoA (By similarity). Acts as 3-hydroxy-2-methylbutyryl-CoA dehydrogenase in branched-chain amino acid catabolic pathway. Catalyzes the oxidation of 3-hydroxy-2-methylbutanoyl-CoA into 2-methyl-3-oxobutanoyl-CoA, a step in isoleucine degradation pathway (By similarity). Has hydroxysteroid dehydrogenase activity toward steroid hormones and bile acids. Catalyzes the oxidation of 3alpha-, 17beta-, 20beta- and 21-hydroxysteroids and 7alpha- and 7beta-hydroxy bile acids. Oxidizes allopregnanolone/brexanolone at the 3alpha-hydroxyl group, which is known to be critical for the activation of gamma-aminobutyric acid receptors (GABAARs) chloride channel. Has phospholipase C-like activity toward cardiolipin and its oxidized species (By similarity). Likely oxidizes the 2'-hydroxyl in the head group of cardiolipin to form a ketone intermediate that undergoes nucleophilic attack by water and fragments into diacylglycerol, dihydroxyacetone and orthophosphate. Has higher affinity for cardiolipin with oxidized fatty acids and may degrade these species during the oxidative stress response to protect cells from apoptosis (By similarity). By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) (By similarity). Essential for structural and functional integrity of mitochondria (PubMed:20077426)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.315", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.315", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.330", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.330", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.1.1.n12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12", "type": "external" }, { "id": "1.1.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.51", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "1.1.1.211", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.211", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0001540 amyloid-beta binding;GO:0051287 NAD binding;GO:0000049 tRNA binding;GO:0005496 steroid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum;GO:0042645 mitochondrial nucleoid;GO:1902494 catalytic complex", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0062173 brexanolone metabolic process;GO:0006631 fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0006699 bile acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O08756-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIM0-1", "uniprot_id": [ { "id": "HAVR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VIM0", "type": "external" } ], "mass": 30934.0, "length": 281, "protein_name": "Hepatitis A virus cellular receptor 2 homolog", "gene_name": "Havcr2", "organism": "Mouse", "refseq_name": "hepatitis A virus cellular receptor 2 homolog precursor", "refseq_ac": [ { "id": "NP_599011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599011", "type": "external" } ], "gene_names_uniprotkb": "Havcr2; Tim3; Timd3", "gene_names_refseq": "Havcr2; TIM-3; Tim3; Timd3", "protein_names_uniprotkb": "Hepatitis A virus cellular receptor 2 homolog; HAVcr-2; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; TIM-3; TIMD-3", "protein_names_refseq": "HAVcr-2; T-cell immunoglobulin and mucin domain containing 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; TIMD-3; hepatitis A virus cellular receptor 2 homolog precursor; hepatitis A virus cellular receptor 2 homolog", "tax_id": 10090, "disease": "subcutaneous panniculitis-like T-cell lymphoma (Disease Ontology:DOID:0070662); cystic fibrosis (Disease Ontology:DOID:1485); transient cerebral ischemia (Disease Ontology:DOID:224); pulmonary tuberculosis (Disease Ontology:DOID:2957); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:171285)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;11725301;11823861;14556006;17620455;18006747;19224762;20083673;20937702;21750661;21807895;22842346;22863785;24567532;25337993;38330550;39237613", "class_list": "", "function": "Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:18006747). Regulates macrophage activation (PubMed:11823861). Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556006, PubMed:18006747). In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits (By similarity). In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN (PubMed:21807895). Expressed on Treg cells can inhibit Th17 cell responses (By similarity). Receptor for LGALS9. Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6 (PubMed:22863785). Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth (PubMed:20937702). However, the function as receptor for LGALS9 has been challenged (By similarity). Also reported to enhance CD8+ T-cell responses to an acute infection such as by Listeria monocytogenes (PubMed:24567532). Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent (PubMed:20083673). May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells (PubMed:19224762). Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells (PubMed:20083673). Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF (PubMed:18006747). In tumor-infiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes (PubMed:22842346). Can enhance mast cell production of Th2 cytokines Il-4, IL-6 and IL-13 (PubMed:17620455). Expressed on natural killer (NK) cells and acts as a coreceptor to enhance IFN-gamma production in response to LGALS9. In contrast, shown to suppress NK cell-mediated cytotoxicity (By similarity). Negatively regulates NK cell function in LPS-induced endotoxic shock (PubMed:25337993)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Macrophage Tim-3 maintains intestinal homeostasis in DSS-induced colitis by suppressing neutrophil necroptosis., [RefSeq, PubMed]; TIM-3 on myeloid cells promotes pulmonary inflammation through increased production of galectin-3. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0001772 immunological synapse", "go_biological_process": "GO:0043032 positive regulation of macrophage activation;GO:0032703 negative regulation of interleukin-2 production;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8VIM0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30681-1", "uniprot_id": [ { "id": "HMGB2_MOUSE", "url": "https://www.uniprot.org/uniprot/P30681", "type": "external" } ], "mass": 24162.0, "length": 210, "protein_name": "High mobility group protein B2", "gene_name": "Hmgb2", "organism": "Mouse", "refseq_name": "high mobility group protein B2", "refseq_ac": [ { "id": "NP_032278", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032278", "type": "external" } ], "gene_names_uniprotkb": "Hmgb2; Hmg2", "gene_names_refseq": "HMG-2; Hmg2; Hmgb2", "protein_names_uniprotkb": "High mobility group protein B2; HMG-2; High mobility group protein 2", "protein_names_refseq": "high mobility group protein 2; high mobility group protein B2", "tax_id": 10090, "disease": "", "pathway": " (mmu:97165); (R-MMU-140342)", "pathway_count": 2, "publication_count": 24, "publication_id_list": "11262228;1408807;19805379;19890330;21750661;22645316;23495099;23806337;24391977;25153642;25306442;26495903;28135057;28528544;29187734;34428180;35984892;37507081;37573836;38376246;38544368;38572649;7720710;9184213", "class_list": "", "function": "HMGB2 Promotes De Novo Lipogenesis to Accelerate Hepatocyte Proliferation During Liver Regeneration., [RefSeq, PubMed]; HMGB2 Release Promotes Pulmonary Hypertension and Predicts Severity and Mortality of Patients With Pulmonary Arterial Hypertension., [RefSeq, PubMed]; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (PubMed:9184213). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (PubMed:19890330). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (By similarity). Has antimicrobial activity in gastrointestinal epithelial tissues (By similarity). Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity (PubMed:25306442). May play a role in germ cell differentiation (PubMed:11262228). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (PubMed:24391977). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (PubMed:19805379)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed]; PRMT7-Dependent Transcriptional Activation of Hmgb2 Aggravates Severe Acute Pancreatitis by Promoting Acsl1-Induced Ferroptosis., [RefSeq, PubMed]; Regulation of DNA damage and transcriptional output in the vasculature through a cytoglobin-HMGB2 axis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UXT1;Q9EQD5", "ec_number_list": [], "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0050786 RAGE receptor binding;GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0097227 sperm annulus;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P30681-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17156-1", "uniprot_id": [ { "id": "HSP72_MOUSE", "url": "https://www.uniprot.org/uniprot/P17156", "type": "external" } ], "mass": 69642.0, "length": 633, "protein_name": "Heat shock-related 70 kDa protein 2", "gene_name": "Hspa2", "organism": "Mouse", "refseq_name": "heat shock-related 70 kDa protein 2", "refseq_ac": [ { "id": "NP_001002012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002012", "type": "external" } ], "gene_names_uniprotkb": "Hspa2; Hcp70.2; Hsp70-2", "gene_names_refseq": "70kDa; HSP70.2; HSP70A2; Hsp70-2; Hspa2", "protein_names_uniprotkb": "Heat shock-related 70 kDa protein 2; Heat shock protein 70.2", "protein_names_refseq": "heat shock 70kDa protein 2; heat shock protein 2; heat shock protein 70.2; heat shock protein, 70 kDa 2; heat shock-related 70 kDa protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:15512); (R-MMU-3371453); (R-MMU-3371497); (R-MMU-3371568); (R-MMU-9833482)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;18250455;18849567;20547853;21224844;23055941;24557841;25605945;3405224;34428180;37749267;39627609", "class_list": "", "function": "Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (By similarity). Plays a role in spermatogenesis (PubMed:24557841). In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (PubMed:24557841)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q99KD7", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0036128 CatSper complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0090084 negative regulation of inclusion body assembly;GO:0001934 positive regulation of protein phosphorylation;GO:0007283 spermatogenesis;GO:0009409 response to cold;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P17156-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JP6-1", "uniprot_id": [ { "id": "HOME3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JP6", "type": "external" } ], "mass": 39694.0, "length": 356, "protein_name": "Homer protein homolog 3", "gene_name": "Homer3", "organism": "Mouse", "refseq_name": "homer protein homolog 3 isoform 1", "refseq_ac": [ { "id": "NP_001139625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139625", "type": "external" } ], "gene_names_uniprotkb": "Homer3", "gene_names_refseq": "Homer3", "protein_names_uniprotkb": "Homer protein homolog 3; Homer-3", "protein_names_refseq": "homer homolog 3; homer protein homolog 3 isoform 1; homer protein homolog 3; homer, neuronal immediate early gene, 3; homer-3", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:26558); (R-MMU-6794361)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11418862;16452087;18218901;21183079;21750661;31319381;32070057;33407765;34428180;35820727;9808458;9808459", "class_list": "", "function": "Data indicate decreased bone density in homer scaffolding proteins (Homer2/3) double knockout (DKO) mice., [RefSeq, PubMed]; Distinct and Overlapping Expression Patterns of the Homer Family of Scaffolding Proteins and Their Encoding Genes in Developing Murine Cephalic Tissues. Publication Status: Online-Only, [RefSeq, PubMed]; HOMER3 facilitates growth factor-mediated beta-Catenin tyrosine phosphorylation and activation to promote metastasis in triple negative breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3Z6N9;Q9Z215", "ec_number_list": [], "go_molecular_function": "GO:0035256 G protein-coupled glutamate receptor binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0032703 negative regulation of interleukin-2 production;GO:0070885 negative regulation of calcineurin-NFAT signaling cascade;GO:0051966 regulation of synaptic transmission, glutamatergic;GO:2001256 regulation of store-operated calcium entry;GO:0007216 G protein-coupled glutamate receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99JP6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VFA1-1", "uniprot_id": [ { "id": "Q8VFA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VFA1", "type": "external" } ], "mass": 35479.0, "length": 320, "protein_name": "Olfactory receptor", "gene_name": "Or1o11", "organism": "Mouse", "refseq_name": "olfactory receptor 108", "refseq_ac": [ { "id": "NP_666676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666676", "type": "external" } ], "gene_names_uniprotkb": "Or1o11; Olfr108", "gene_names_refseq": "MOR156-5; Olfr108; Or1o11", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PSCP-1893605-1894534; olfactory receptor 108; olfactory receptor MOR156-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:258457)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VFA1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BUW1-1", "uniprot_id": [ { "id": "KCNKA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BUW1", "type": "external" } ], "mass": 59401.0, "length": 535, "protein_name": "Potassium channel subfamily K member 10", "gene_name": "Kcnk10", "organism": "Mouse", "refseq_name": "potassium channel subfamily K member 10 isoform 4", "refseq_ac": [ { "id": "NP_001303595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303595", "type": "external" } ], "gene_names_uniprotkb": "Kcnk10", "gene_names_refseq": "1700024D23Rik; 3010005K24Rik; Kcnk10; Trek2", "protein_names_uniprotkb": "Potassium channel subfamily K member 10; Outward rectifying potassium channel protein TREK-2; TREK-2 K(+) channel subunit", "protein_names_refseq": "TREK-2 K(+) channel subunit; TREK-2 two-pore-domain K+ channel; outward rectifying potassium channel TREK2; outward rectifying potassium channel protein TREK-2; potassium channel subfamily K member 10 isoform 4", "tax_id": 10090, "disease": "heart conduction disease (Disease Ontology:DOID:10273); brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (mmu:72258); (R-MMU-1299503); (R-MMU-5576886)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "15351740;15572365;19439530;19667202;21750661;27035963;27035965;30573346;32641496;33586023;34458705;37296621", "class_list": "", "function": "Beta-COP Suppresses the Surface Expression of the TREK2. Publication Status: Online-Only, [RefSeq, PubMed]; Higher expression of KCNK10 (TREK-2) K(+) channels and their functional upregulation by lipopolysaccharide treatment in mouse peritoneal B1a cells., [RefSeq, PubMed]; Identification of the large-conductance background K+ channel in mouse B cells as TREK-2., [RefSeq, PubMed]; K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, acidic pH, heat and lipids (PubMed:27035963, PubMed:27035965). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:19667202, PubMed:27035963, PubMed:27035965). In trigeminal ganglia sensory neurons, the heterodimer of KCNK10/TREK-2 and KCNK18/TRESK inhibits neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency (PubMed:30573346, PubMed:32641496, PubMed:34458705). Permeable to other monovalent ions such as Rb(+) and Cs(+) (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; TREK-1, TREK-2, and TRAAK are lysophosphatidic acid-operated K+ channels Erratum:[J Biol Chem. 2013 Sep 6;288(36):26178], [RefSeq, PubMed]; TREK-2 contributes to the background K+ conductance in MIN6 cells, and may regulate depolarization-induced secretion of insulin, [RefSeq, PubMed]; TRESK and TREK-2 two-pore-domain potassium channel subunits form functional heterodimers in primary somatosensory neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1Y7VJZ9;F6YU65;Q9CX88", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0098782 mechanosensitive potassium channel activity;GO:0046872 metal ion binding;GO:0005267 potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050877 nervous system process;GO:0071805 potassium ion transmembrane transport;GO:1904551 cellular response to arachidonate", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BUW1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q2E4-1", "uniprot_id": [ { "id": "E9Q2E4_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q2E4", "type": "external" } ], "mass": 484128.0, "length": 4418, "protein_name": "HECT domain E3 ubiquitin protein ligase 4", "gene_name": "Hectd4", "organism": "Mouse", "refseq_name": "probable E3 ubiquitin-protein ligase HECTD4", "refseq_ac": [ { "id": "NP_852086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852086", "type": "external" } ], "gene_names_uniprotkb": "Hectd4", "gene_names_refseq": "A130010L24; EG545802; Gm15800; Hectd4; mKIAA0614", "protein_names_uniprotkb": "HECT domain E3 ubiquitin protein ligase 4", "protein_names_refseq": "probable E3 ubiquitin-protein ligase HECTD4", "tax_id": 10090, "disease": "", "pathway": " (mmu:269700)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;16452087;21750661;25428506;31361958", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "", "go_biological_process": "GO:0042593 glucose homeostasis;GO:0006006 glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "E9Q2E4-1", "record_type": "protein", "filter_code": "0000000.1000101.001000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { 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Zfp944", "gene_names_refseq": "3110048L19Rik; Zfp942", "protein_names_uniprotkb": "Zinc finger protein 942", "protein_names_refseq": "uncharacterized protein LOC73233", "tax_id": 10090, "disease": "", "pathway": " (mmu:73233); (R-MMU-212436); (R-MMU-9843940)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q0I6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B8JJA7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YYJ7-1", "uniprot_id": [ { "id": "D3YYJ7_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YYJ7", "type": "external" } ], "mass": 24549.0, "length": 219, "protein_name": "Pentraxin family member", "gene_name": "Mptx2", "organism": "Mouse", "refseq_name": "Mucosal pentraxin precursor", "refseq_ac": [ { "id": "NP_001191940", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191940", "type": "external" } ], "gene_names_uniprotkb": "Mptx2; Gm11062", "gene_names_refseq": "Gm11062; Mptx2", "protein_names_uniprotkb": "Pentraxin family member", "protein_names_refseq": "Mucosal pentraxin precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:100504232)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;38218976", "class_list": "", "function": "Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy. 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May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). 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Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry. Responsible for regulating intracellular pH homeostasis, in particular in neural tissues. Acts as a negative regulator of dendritic spine growth. Plays a role in postsynaptic remodeling and signaling. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VGC5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VGG1-1", "uniprot_id": [ { "id": "Q8VGG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VGG1", "type": "external" } ], "mass": 34358.0, "length": 304, "protein_name": "Olfactory receptor", "gene_name": "Or4c112", "organism": "Mouse", "refseq_name": "olfactory receptor 1217", "refseq_ac": [ { "id": "NP_667112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_667112", "type": "external" } ], "gene_names_uniprotkb": "Or4c112; Olfr1217", "gene_names_refseq": "MOR233-4; Olfr1217; Or4c112", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-50504545-50503631; olfactory receptor 1217; olfactory receptor MOR233-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:258903)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VGG1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VGK0-1", "uniprot_id": [ { "id": "Q8VGK0_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VGK0", "type": "external" } ], "mass": 34722.0, "length": 311, "protein_name": "Olfactory receptor", "gene_name": "Or1n1b", "organism": "Mouse", "refseq_name": "olfactory receptor family 1 subfamily N member 1B", "refseq_ac": [ { "id": "NP_667152", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_667152", "type": "external" } ], "gene_names_uniprotkb": "Or1n1b; Olfr351; Olfr353", "gene_names_refseq": "MOR127-3; Olfr353; Or1n1b", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2NLDC-33585366-33584431; olfactory receptor 353; olfactory receptor MOR127-3; olfactory receptor family 1 subfamily N member 1B", "tax_id": 10090, "disease": "", "pathway": " (mmu:258943)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VGK0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VGW6-1", "uniprot_id": [ { "id": "Q8VGW6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VGW6", "type": "external" } ], "mass": 35351.0, "length": 315, "protein_name": "Olfactory receptor", "gene_name": "Or2b4", "organism": "Mouse", "refseq_name": "olfactory receptor 124", "refseq_ac": [ { "id": "NP_667273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_667273", "type": "external" } ], "gene_names_uniprotkb": "Or2b4; Olfr124", "gene_names_refseq": "A3; MOR256-3; Olfr124; Or2b4; SR1", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PSCP-2264806-2265753; olfactory receptor 124; olfactory receptor MOR256-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:259064)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;26090619", "class_list": "", "function": "Analysis of crucial residues for the function of G-protein coupled receptors using the mouse MOR256-3 (Olfr124), [RefSeq, PubMed]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VGW6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAE2-1", "uniprot_id": [ { "id": "RMXL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAE2", "type": "external" } ], "mass": 41912.0, "length": 385, "protein_name": "RNA-binding motif protein, X-linked-like-2", "gene_name": "Rbmxl2", "organism": "Mouse", "refseq_name": "RNA-binding motif protein, X-linked-like-2", "refseq_ac": [ { "id": "NP_083936", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083936", "type": "external" } ], "gene_names_uniprotkb": "Rbmxl2; Hnrnpgt", "gene_names_refseq": "1700012H05Rik; Hnrnpg-t; Rbmxl2; hnRNP G-T", "protein_names_uniprotkb": "RNA-binding motif protein, X-linked-like-2; Testis-specific heterogeneous nuclear ribonucleoprotein G-T; hnRNP G-T", "protein_names_refseq": "RNA-binding motif protein, X-linked-like-2; testes-specific heterogenous nuclear ribonucleoprotein G-T; testis-specific heterogeneous nuclear ribonucleoprotein G-T", "tax_id": 10090, "disease": "", "pathway": " (mmu:76572)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18562473;30674417", "class_list": "", "function": "Haploinsufficiency of hnRNPGT results in abnormal sperm production in the mouse., [RefSeq, PubMed]; RNA-binding protein involved in alternative splicing in the testis during spermatogenesis., [UniProtKB, PubMed]; Rbmxl2 retrogene has been conserved across mammals as part of a splicing control mechanism that is fundamentally important to germ cell biology. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005681 spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DAE2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKE1-1", "uniprot_id": [ { "id": "TREM3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKE1", "type": "external" } ], "mass": 20452.0, "length": 183, "protein_name": "Triggering receptor expressed on myeloid cells 3", "gene_name": "Trem3", "organism": "Mouse", "refseq_name": "triggering receptor expressed on myeloid cells 3 precursor", "refseq_ac": [ { "id": "NP_067382", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067382", "type": "external" } ], "gene_names_uniprotkb": "Trem3", "gene_names_refseq": "TREM-3; Trem3", "protein_names_uniprotkb": "Triggering receptor expressed on myeloid cells 3; TREM-3", "protein_names_refseq": "triggering receptor expressed on monocytes 3; triggering receptor expressed on myeloid cells 3 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:58218)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11754004;25860078;34125599", "class_list": "", "function": "Forms a receptor signaling complex with TYROBP/DAP12 which mediates activation of macrophages as part of the innate immune response., [UniProtKB, PubMed]; Like TREM-1 and TREM-2, TREM-3 signals through DAP12., [RefSeq, PubMed]; Reduced Uterine Tissue Damage during Chlamydia muridarum Infection in TREM-1,3-Deficient Mice., [RefSeq, PubMed]; TREM-1/TREM-3 macrophage expression improved host defense against Klebsiella-derived pneumosepsis, whereas TREM-2 did not have a role., [RefSeq, PubMed]; The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and is thought to function as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein has been reported to associate with the adaptor protein Dap-12 to form a receptor signaling complex that activates myeloid cells. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0070945 neutrophil-mediated killing of gram-negative bacterium;GO:0016477 cell migration;GO:0045089 positive regulation of innate immune response;GO:0030593 neutrophil chemotaxis;GO:0072672 neutrophil extravasation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JKE1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21995-1", "uniprot_id": [ { "id": "EMB_MOUSE", "url": "https://www.uniprot.org/uniprot/P21995", "type": "external" } ], "mass": 37064.0, "length": 330, "protein_name": "Embigin", "gene_name": "Emb", "organism": "Mouse", "refseq_name": "embigin precursor", "refseq_ac": [ { "id": "NP_034460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034460", "type": "external" } ], "gene_names_uniprotkb": "Emb; Gp70", "gene_names_refseq": "Emb; Gp70", "protein_names_uniprotkb": "Embigin; Teratocarcinoma glycoprotein Gp-70", "protein_names_refseq": "embigin precursor; glycoprotein 70; teratocarcinoma glycoprotein Gp-70", "tax_id": 10090, "disease": "", "pathway": " (mmu:13723); (R-MMU-433692)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;19164284;19349973;19656770;20173027;21750661;25428506;2963822;30084848;30779550;30899004;34428180;38458190;40885482", "class_list": "", "function": "Osteomacs promote maintenance of murine hematopoiesis through megakaryocyte-induced upregulation of Embigin and CD166., [RefSeq, PubMed]; Plays a role in targeting the monocarboxylate transporters SLC16A1, SLC16A6 and SLC16A7 to the cell membrane (By similarity). Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 17, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFF1;Q8C2J8;Q8C543;Q96C38", "ec_number_list": [], "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0045202 synapse", "go_biological_process": "GO:0007155 cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007411 axon guidance;GO:0070593 dendrite self-avoidance;GO:0035879 plasma membrane lactate transport", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "P21995-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52793-1", "uniprot_id": [ { "id": "EFNA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P52793", "type": "external" } ], "mass": 23802.0, "length": 205, "protein_name": "Ephrin-A1", "gene_name": "Efna1", "organism": "Mouse", "refseq_name": "ephrin-A1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_034237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034237", "type": "external" } ], "gene_names_uniprotkb": "Efna1; Epgl1; Epl1; Lerk1", "gene_names_refseq": "B61; Efl1; Efna1; Epl1; Eplg1; Lerk1", "protein_names_uniprotkb": "Ephrin-A1; EPH-related receptor tyrosine kinase ligand 1; Immediate early response protein B61; LERK-1", "protein_names_refseq": "EPH-related receptor tyrosine kinase ligand 1; ephrin-A1 isoform 1 precursor; immediate early response protein B61", "tax_id": 10090, "disease": "", "pathway": " (mmu:13636); (R-MMU-2682334); (R-MMU-3928663); (R-MMU-3928665)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;16782872;17143272;18387945;20960543;21750661;25428506;27446912;30899004;34428180;7675446;8903354", "class_list": "", "function": "Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Involved in angiogenesis, regulating vascular endothelial cell differentiation and migration through activation of EPHA2. Acts as a ligand for EPHA3, inhibiting epithelial-to-mesenchymal transition of cardiac cells and playing a role in heart development. May also contribute to dendritic spine morphogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97331", "ec_number_list": [], "go_molecular_function": "GO:0046875 ephrin receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0098552 side of membrane;GO:0016020 membrane", "go_biological_process": "GO:0033628 regulation of cell adhesion mediated by integrin;GO:0050770 regulation of axonogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P52793-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70372-1", "uniprot_id": [ { "id": "ELAV1_MOUSE", "url": "https://www.uniprot.org/uniprot/P70372", "type": "external" } ], "mass": 36169.0, "length": 326, "protein_name": "ELAV-like protein 1", "gene_name": "Elavl1", "organism": "Mouse", "refseq_name": "ELAV-like protein 1", "refseq_ac": [ { "id": "NP_034615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034615", "type": "external" } ], "gene_names_uniprotkb": "Elavl1; Elra; Hua", "gene_names_refseq": "2410055N02Rik; Elavl1; HUR; Hua", "protein_names_uniprotkb": "ELAV-like protein 1; Elav-like generic protein; Hu-antigen R; HuR; MelG", "protein_names_refseq": "ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R); ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); ELAV-like protein 1; HU-antigen A; elav-like generic protein; hu-antigen R; melG", "tax_id": 10090, "disease": "degenerative disc disease (Disease Ontology:DOID:90)", "pathway": " (mmu:15568); (R-MMU-450520)", "pathway_count": 2, "publication_count": 26, "publication_id_list": "12237300;19224205;20173027;21183079;21402775;21745814;22645316;24129315;24394384;24788674;24968827;25153642;25428506;27616329;28135057;28383062;28528544;29187734;30084848;31219806;33300544;34428180;35820727;37453647;7753842;9763509", "class_list": "", "function": "RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (PubMed:24394384). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (By similarity). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (PubMed:21402775). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:27616329)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60745;Q78QY3", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0060965 negative regulation of miRNA-mediated gene silencing;GO:0008283 cell population proliferation;GO:0032930 positive regulation of superoxide anion generation;GO:0048255 mRNA stabilization;GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P70372-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CBF3-1", "uniprot_id": [ { "id": "EPHB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CBF3", "type": "external" } ], "mass": 109881.0, "length": 984, "protein_name": "Ephrin type-B receptor 1", "gene_name": "Ephb1", "organism": "Mouse", "refseq_name": "ephrin type-B receptor 1 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001161768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161768", "type": "external" } ], "gene_names_uniprotkb": "Ephb1", "gene_names_refseq": "9330129L11; C130099E04Rik; Cek6; Elkh; Elk; Ephb1; Hek6; Net", "protein_names_uniprotkb": "Ephrin type-B receptor 1; 2.7.10.1", "protein_names_refseq": "ephrin type-B receptor 1 isoform 2 precursor; ephrin type-B receptor 1", "tax_id": 10090, "disease": "aortic dissection (Disease Ontology:DOID:0080685); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:270190); (R-MMU-2682334); (R-MMU-3928662); (R-MMU-3928664); (R-MMU-3928665)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;12223469;12925710;12971893;14691139;18034775;18057206;18524895;19025592;27446912;32238105;38601015;9430661;9883737", "class_list": "", "function": "EphB1 causes retinal damage through inflammatory pathways in the retina and retinal Muller cells. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (PubMed:27446912)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 3, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B1B1C2;Q3UY27;Q6PG23;Q8CBE2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0044877 protein-containing complex binding;GO:0005005 transmembrane-ephrin receptor activity;GO:0008046 axon guidance receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0021545 cranial nerve development;GO:0021934 hindbrain tangential cell migration;GO:0001525 angiogenesis;GO:0010628 positive regulation of gene expression;GO:0048013 ephrin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8CBF3-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C0HKE2-1", "uniprot_id": [ { "id": "H2A1C_MOUSE", "url": "https://www.uniprot.org/uniprot/C0HKE2", "type": "external" } ], "mass": 14135.0, "length": 130, "protein_name": "Histone H2A type 1-C", "gene_name": "H2ac6", "organism": "Mouse", "refseq_name": "histone H2A type 1-C", "refseq_ac": [ { "id": "NP_835496", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_835496", "type": "external" } ], "gene_names_uniprotkb": "H2ac6; Hist1h2ac", "gene_names_refseq": "H2ac6; Hist1h2ac", "protein_names_uniprotkb": "Histone H2A type 1-C; H2A-clustered histone 6", "protein_names_refseq": "histone 1, H2ac; histone H2A type 1-C; histone H2A type 1; histone cluster 1, H2ac", "tax_id": 10090, "disease": "", "pathway": " (mmu:319164); (mmu:319165); (mmu:319166); (mmu:319167); (mmu:319170); (mmu:319171); (mmu:319172); (mmu:319191); (mmu:665433); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214858); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-5689901); (R-MMU-606279); (R-MMU-8936459); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 26, "publication_count": 10, "publication_id_list": "12408966;15509584;15525528;16699504;21925322;24352239;24681537;27105115;30154464;7217105", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P10812;P22752;Q149U0;Q5SZZ2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome;GO:0043505 CENP-A containing nucleosome", "go_biological_process": "GO:0006325 chromatin organization;GO:0031507 heterochromatin formation;GO:0061644 protein localization to CENP-A containing chromatin", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "C0HKE2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69ZR2-1", "uniprot_id": [ { "id": "HECD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69ZR2", "type": "external" } ], "mass": 290086.0, "length": 2618, "protein_name": "E3 ubiquitin-protein ligase HECTD1", "gene_name": "Hectd1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hectd1; Kiaa1131; Opm", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase HECTD1; 2.3.2.26; HECT domain-containing protein 1; HECT-type E3 ubiquitin transferase HECTD1; Protein open mind", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;17242355;17442300;21183079;21750661;21952136;22431752;22517741;22645316;25428506;25605945;30084848;30779550;31219806;32782141;33711283;34428180;35820727;36210013;36852467;37507081;39927985;40021952;40885482;40997131", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:22431752, PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (PubMed:22431752). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells impairs their emigration and is consequently essential for the correct development of the cranial neural folds and neural tube closure (PubMed:17442300, PubMed:22431752). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016607 nuclear speck", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0003170 heart valve development;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0001843 neural tube closure;GO:1903077 negative regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "Q69ZR2-1", "record_type": "protein", "filter_code": "0000000.1100100.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21729-1", "uniprot_id": [ { "id": "GRPR_MOUSE", "url": "https://www.uniprot.org/uniprot/P21729", "type": "external" } ], "mass": 43215.0, "length": 384, "protein_name": "Gastrin-releasing peptide receptor", "gene_name": "Grpr", "organism": "Mouse", "refseq_name": "gastrin-releasing peptide receptor", "refseq_ac": [ { "id": "NP_032203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032203", "type": "external" } ], "gene_names_uniprotkb": "Grpr", "gene_names_refseq": "GRP-R; Grpr", "protein_names_uniprotkb": "Gastrin-releasing peptide receptor; GRP-R; GRP-preferring bombesin receptor", "protein_names_refseq": "GRP-preferring bombesin receptor; gastrin-releasing peptide receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:14829); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10689196;11093789;12176666;12526815;1671171;1707129;17653196;26658875;26855425;28280205;34610277;8391296;9345264", "class_list": "", "function": "Receptor for gastrin-releasing peptide (GRP) (PubMed:12526815, PubMed:1671171, PubMed:1707129, PubMed:26658875, PubMed:9345264). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation (PubMed:26658875). Contributes to the regulation of food intake (PubMed:12176666). Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain (PubMed:17653196, PubMed:26658875, PubMed:28280205). Contributes primarily to nonhistaminergic itch sensation (PubMed:28280205). In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (PubMed:12526815). In another study, shown to contribute to disinhibition of glutamatergic cells in the auditory cortex via signaling on vasoactive intestinal peptide-expressing cells which leads to enhanced auditory fear memories (PubMed:34610277). Contributes to the induction of sighing through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (PubMed:26855425)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a multipass membrane protein that functions as a receptor for gastrin releasing peptide. Signalling through this receptor is important in a variety of physiological processes, including responses to itching, satiety, and fear. [provided by RefSeq, May 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 4, "mined_n_glycosites": 4, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q53WV4", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity;GO:0008188 neuropeptide receptor activity;GO:0004946 bombesin receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007611 learning or memory;GO:0042127 regulation of cell population proliferation;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0035176 social behavior", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P21729-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000100000001.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47791-1", "uniprot_id": [ { "id": "GSHR_MOUSE", "url": "https://www.uniprot.org/uniprot/P47791", "type": "external" } ], "mass": 53663.0, "length": 500, "protein_name": "Glutathione reductase, mitochondrial", "gene_name": "Gsr", "organism": "Mouse", "refseq_name": "glutathione reductase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_034474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034474", "type": "external" } ], "gene_names_uniprotkb": "Gsr; Gr1", "gene_names_refseq": "D8Ertd238e; Gr-1; Gr1; Gsr", "protein_names_uniprotkb": "Glutathione reductase, mitochondrial; 1.8.1.7; GRase; GR", "protein_names_refseq": "GRase; GR; glutathione reductase 1; glutathione reductase, mitochondrial precursor; glutathione reductase, mitochondrial", "tax_id": 10090, "disease": "hemorrhagic cystitis (Disease Ontology:DOID:0050859); congenital nonspherocytic hemolytic anemia 10 (Disease Ontology:DOID:0051009); myoglobinuria (Disease Ontology:DOID:0080108); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Parkinsonism (Disease Ontology:DOID:0080855); Heinz body anemia (Disease Ontology:DOID:0111363); lymphoid leukemia (Disease Ontology:DOID:1037); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); osteoporosis (Disease Ontology:DOID:11476); diabetic angiopathy (Disease Ontology:DOID:11713); limb-girdle muscular dystrophy (Disease Ontology:DOID:11724); iron deficiency anemia (Disease Ontology:DOID:11758); beta thalassemia (Disease Ontology:DOID:12241); acute kidney tubular necrosis (Disease Ontology:DOID:12556); Huntington's disease (Disease Ontology:DOID:12858); dementia (Disease Ontology:DOID:1307); diabetic cataract (Disease Ontology:DOID:13328); transient cerebral ischemia (Disease Ontology:DOID:224); acute kidney failure (Disease Ontology:DOID:3021); coronary artery disease (Disease Ontology:DOID:3393); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); myocardial infarction (Disease Ontology:DOID:5844); nephrolithiasis (Disease Ontology:DOID:585); congenital hemolytic anemia (Disease Ontology:DOID:589); peptic ulcer disease (Disease Ontology:DOID:750); end stage renal disease (Disease Ontology:DOID:783); hyperthyroidism (Disease Ontology:DOID:7998); cataract (Disease Ontology:DOID:83); alcoholic gastritis (Disease Ontology:DOID:8680); polycythemia vera (Disease Ontology:DOID:8997); acute myeloid leukemia (Disease Ontology:DOID:9119); diabetes mellitus (Disease Ontology:DOID:9351); senile cataract (Disease Ontology:DOID:9669); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:14782); (R-MMU-3299685); (R-MMU-499943); (R-MMU-5628897)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;2185014;23576753;25428506;28011936;28135057;28528544;32455850;37453647;37507081;37828378;9268726", "class_list": "", "function": "Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol., [UniProtKB, UniProtKB]; How Does Ginsenoside Rh2 Mitigate Adipogenesis in Cultured Cells and Obese Mice? Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 36, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNC2;Q8BN97;Q8C9Z6", "ec_number_list": [ { "id": "1.8.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.7", "type": "external" } ], "go_molecular_function": "GO:0043295 glutathione binding;GO:0042802 identical protein binding;GO:0050660 flavin adenine dinucleotide binding;GO:0050661 NADP binding;GO:0004362 glutathione-disulfide reductase (NADPH) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0034599 cellular response to oxidative stress;GO:0045454 cell redox homeostasis;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P47791-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61425-1", "uniprot_id": [ { "id": "HCDH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61425", "type": "external" } ], "mass": 34464.0, "length": 314, "protein_name": "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial", "gene_name": "Hadh", "organism": "Mouse", "refseq_name": "hydroxyacyl-coenzyme A dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_032238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032238", "type": "external" } ], "gene_names_uniprotkb": "Hadh; Hadhsc; Mschad; Schad", "gene_names_refseq": "HCDH; Hadhsc; Hadh; Schad", "protein_names_uniprotkb": "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; 1.1.1.35; HCDH; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenase", "protein_names_refseq": "L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial precursor; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; hydroxylacyl-Coenzyme A dehydrogenase-dehydrogenase; medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase; short-chain 3-hydroxyacyl-CoA dehydrogenase", "tax_id": 10090, "disease": "familial hyperinsulinemic hypoglycemia 4 (Disease Ontology:DOID:0070215); myocardial infarction (Disease Ontology:DOID:5844); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:15107); (R-MMU-77310); (R-MMU-77346); (R-MMU-77348); (R-MMU-77350); (R-MMU-77352); (R-MMU-9837999)", "pathway_count": 7, "publication_count": 11, "publication_id_list": "20670938;23576753;23806337;34428180;35339755;36288343;36398584;37453647;37507081;39927985;7642117", "class_list": "", "function": "Hadh deficiency induced oligoasthenoteratozoospermia through the TNF-alpha/Bcl-2 pathway in male mice., [RefSeq, PubMed]; Inhibits cell proliferation., [UniProtKB, PubMed]; Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (By similarity). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (PubMed:20670938). Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes (PubMed:36398584)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TF75;Q3THK8;Q3UFI0;Q8K149;Q925U9", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "1.1.1.211", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.211", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0070403 NAD+ binding;GO:0003857 (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0046676 negative regulation of insulin secretion;GO:0050796 regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q61425-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CJI4-1", "uniprot_id": [ { "id": "H1FNT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CJI4", "type": "external" } ], "mass": 44400.0, "length": 398, "protein_name": "Testis-specific H1 histone", "gene_name": "H1-7", "organism": "Mouse", "refseq_name": "testis-specific H1 histone", "refseq_ac": [ { "id": "NP_081580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081580", "type": "external" } ], "gene_names_uniprotkb": "H1-7; H1f7; H1fnt; Hanp1", "gene_names_refseq": "1700026P10Rik; H1-7; H1.7; H1f7; H1fnt; H1t2; Hanp1; mH1t2", "protein_names_uniprotkb": "Testis-specific H1 histone; Haploid germ cell-specific nuclear protein 1; Histone H1.7; Histone H1t2", "protein_names_refseq": "H1 histone family, member N, testis-specific; expressed in haploid spermatids during spermiogenesis, specifically at the apical pole of round and elongating spermatids; haploid germ cell-specific nuclear protein 1; histone H1.7; histone H1t2; testis-specific H1 histone", "tax_id": 10090, "disease": "", "pathway": " (mmu:70069)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15710904;16055721;16765935", "class_list": "", "function": "Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1., [UniProtKB, PubMed, PubMed]; H1T2 can be a useful molecular marker revealing chromatin disorganization in spermatids., [RefSeq, PubMed]; HANP1/H1T2 is essential for nuclear formation in functional spermatozoa and is specifically involved in the replacement of histones with protamines during spermiogenesis, [RefSeq, PubMed]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. This gene encodes a testis specific protein that is required for spermatogenesis and male fertility. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5GKZ6;Q5RKV2;Q9CVV3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0030261 chromosome condensation;GO:0007290 spermatid nucleus elongation;GO:0035092 sperm DNA condensation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CJI4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08680-1", "uniprot_id": [ { "id": "HEM0_MOUSE", "url": "https://www.uniprot.org/uniprot/P08680", "type": "external" } ], "mass": 64753.0, "length": 587, "protein_name": "5-aminolevulinate synthase, erythroid-specific, mitochondrial", "gene_name": "Alas2", "organism": "Mouse", "refseq_name": "5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform b", "refseq_ac": [ { "id": "NP_001095916", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095916", "type": "external" } ], "gene_names_uniprotkb": "Alas2", "gene_names_refseq": "ALAS-E; ALASE; ALAS; Alas-2; Alas2", "protein_names_uniprotkb": "5-aminolevulinate synthase, erythroid-specific, mitochondrial; 2.3.1.37; 5-aminolevulinic acid synthase 2; ALAS-E; Delta-ALA synthase 2; Delta-aminolevulinate synthase 2", "protein_names_refseq": "5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform b; 5-aminolevulinate synthase, erythroid-specific, mitochondrial; 5-aminolevulinic acid synthase 2; delta-ALA synthase 2; delta-aminolevulinate synthase 2; erythroid-specific ALAS", "tax_id": 10090, "disease": "sideroblastic anemia 1 (Disease Ontology:DOID:0060063); erythropoietic protoporphyria (Disease Ontology:DOID:13270); cutaneous porphyria (Disease Ontology:DOID:13271); hemochromatosis (Disease Ontology:DOID:2352); anemia (Disease Ontology:DOID:2355); bilirubin metabolic disorder (Disease Ontology:DOID:2741); acute intermittent porphyria (Disease Ontology:DOID:3890); hemolytic anemia (Disease Ontology:DOID:583); sideroblastic anemia (Disease Ontology:DOID:8955)", "pathway": " (mmu:11656); (R-MMU-189451)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11566198;21750661;3557128;8268805", "class_list": "", "function": "Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products (PubMed:3557128, PubMed:8268805). Contributes significantly to heme formation during erythropoiesis (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q64452;Q9DCN0", "ec_number_list": [ { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" } ], "go_molecular_function": "GO:0120225 coenzyme A binding;GO:0030170 pyridoxal phosphate binding;GO:0003870 5-aminolevulinate synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0001666 response to hypoxia;GO:0006879 intracellular iron ion homeostasis;GO:0030218 erythrocyte differentiation;GO:0006783 heme biosynthetic process;GO:0006782 protoporphyrinogen IX biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P08680-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09106-1", "uniprot_id": [ { "id": "HDAC1_MOUSE", "url": "https://www.uniprot.org/uniprot/O09106", "type": "external" } ], "mass": 55075.0, "length": 482, "protein_name": "Histone deacetylase 1", "gene_name": "Hdac1", "organism": "Mouse", "refseq_name": "histone deacetylase 1", "refseq_ac": [ { "id": "NP_032254", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032254", "type": "external" } ], "gene_names_uniprotkb": "Hdac1", "gene_names_refseq": "HD1; Hdac1-ps; Hdac1; MommeD5; RPD3", "protein_names_uniprotkb": "Histone deacetylase 1; 3.5.1.-; 3.5.1.98; HD1; Protein deacetylase HDAC1; Protein deacylase HDAC1", "protein_names_refseq": "histone deacetylase 1; protein deacetylase HDAC1; protein deacylase HDAC1; protein decrotonylase HDAC1", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); glaucoma (Disease Ontology:DOID:1686); multiple sclerosis (Disease Ontology:DOID:2377); breast carcinoma (Disease Ontology:DOID:3459); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); pulmonary hypertension (Disease Ontology:DOID:6432); prostate carcinoma in situ (Disease Ontology:DOID:8634); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); colorectal cancer (Disease Ontology:DOID:9256); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:433759); (R-MMU-1538133); (R-MMU-201722); (R-MMU-2173795); (R-MMU-3214815); (R-MMU-350054); (R-MMU-3769402); (R-MMU-4551638); (R-MMU-6804758); (R-MMU-73762); (R-MMU-8936459); (R-MMU-8943724); (R-MMU-9022692); (R-MMU-9701898); (R-MMU-9764725); (R-MMU-9824594); (R-MMU-9825892); (R-MMU-983231); (R-MMU-9937850); (R-MMU-9940951)", "pathway_count": 20, "publication_count": 59, "publication_id_list": "10.1101/2023.09.13.557529;10615135;10984530;11022042;11115394;11533236;11788710;11909966;12198165;12398767;12616525;14645126;15060175;15140878;15226430;15542849;15711539;16085498;16107708;16166625;16537907;16611996;16805913;17707228;18849567;19144721;19483677;19501046;20124407;20154723;20478393;20675388;21177534;21454521;21937600;21960634;22242125;23624624;23824843;24227653;24413057;24736997;25153642;27806305;27903773;28135057;28528544;28554894;29187734;30228260;30279482;33831416;34075040;34180153;34428180;35341968;37828378;9271381;9702189", "class_list": "", "function": "Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:10615135, PubMed:15542849, PubMed:21960634, PubMed:30279482). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:10615135, PubMed:15542849, PubMed:21960634). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:10615135, PubMed:21960634). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). As part of the SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (By similarity). Also functions as a deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3, STAT3, ZNF76 and TSHZ3 (By similarity). Deacetylates SP proteins, SP1 and SP3, and regulates their function (By similarity). Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons (By similarity). Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation (By similarity). Deacetylates TSHZ3 and regulates its transcriptional repressor activity (By similarity). Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B (By similarity). Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity (By similarity). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:17707228). Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer (PubMed:15226430, PubMed:24736997). Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation (PubMed:15226430). In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase and delactylase by mediating decrotonylation ((2E)-butenoyl) and delactylation (lactoyl) of histones, respectively (PubMed:30279482)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97476", "ec_number_list": [ { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.37", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.9.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.-", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "3.5.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.48", "type": "external" }, { "id": "3.5.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.62", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65", "type": "external" }, { "id": "1.14.99.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "1.21.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.21.99.4", "type": "external" } ], "go_molecular_function": "GO:0035851 Krueppel-associated box domain binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0019899 enzyme binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043025 neuronal cell body", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:0009913 epidermal cell differentiation;GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 6.4, "record_id": "O09106-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10854-1", "uniprot_id": [ { "id": "H2B1M_MOUSE", "url": "https://www.uniprot.org/uniprot/P10854", "type": "external" } ], "mass": 13936.0, "length": 126, "protein_name": "Histone H2B type 1-M", "gene_name": "H2bc14", "organism": "Mouse", "refseq_name": "histone H2B type 1-M", "refseq_ac": [ { "id": "NP_835507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_835507", "type": "external" } ], "gene_names_uniprotkb": "H2bc14; Hist1h2bm", "gene_names_refseq": "H2b-291b; H2bc14; Hist1h2bm", "protein_names_uniprotkb": "Histone H2B type 1-M; H2B 291B", "protein_names_refseq": "H2B 291B; histone 1, H2bm; histone H2B type 1-M; histone cluster 1, H2bm", "tax_id": 10090, "disease": "", "pathway": " (mmu:319186); (R-MMU-3214847)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "12408966;15197225;16039583;20647423;21925322;22389435;23806337;24681537;25428507;27105115;30154464;31645732;32822587;3562244;37507081", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5T008", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000786 nucleosome", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P10854-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22315-1", "uniprot_id": [ { "id": "HEMH_MOUSE", "url": "https://www.uniprot.org/uniprot/P22315", "type": "external" } ], "mass": 47422.0, "length": 422, "protein_name": "Ferrochelatase, mitochondrial", "gene_name": "Fech", "organism": "Mouse", "refseq_name": "ferrochelatase, mitochondrial isoform 2", "refseq_ac": [ { "id": "NP_001334984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334984", "type": "external" } ], "gene_names_uniprotkb": "Fech", "gene_names_refseq": "Fcl; Fech; fch", "protein_names_uniprotkb": "Ferrochelatase, mitochondrial; 4.98.1.1; Heme synthase; Protoheme ferro-lyase", "protein_names_refseq": "ferrochelatase, mitochondrial isoform 2; ferrochelatase, mitochondrial; heme synthase; heme synthetase; protoheme ferro-lyase", "tax_id": 10090, "disease": "erythropoietic protoporphyria (Disease Ontology:DOID:13270); cutaneous porphyria (Disease Ontology:DOID:13271); cancer (Disease Ontology:DOID:162); colon adenocarcinoma (Disease Ontology:DOID:234)", "pathway": " (mmu:14151); (R-MMU-189451); (R-MMU-9837999)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "16452087;1704134;20427704;21750661;2246229;23576753;23806337;27599036;27802388;28011936;30366982;30765471;31599954;32716567;8276824;8325637", "class_list": "", "function": "Catalyzes the ferrous insertion into protoporphyrin IX., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Ferrochelatase regulates retinal neovascularization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q544X6", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0030350 iron-responsive element binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane;GO:0043190 ATP-binding cassette (ABC) transporter complex", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0030218 erythrocyte differentiation;GO:0034379 very-low-density lipoprotein particle assembly;GO:0006779 porphyrin-containing compound biosynthetic process;GO:0009416 response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P22315-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34914-1", "uniprot_id": [ { "id": "HYES_MOUSE", "url": "https://www.uniprot.org/uniprot/P34914", "type": "external" } ], "mass": 62515.0, "length": 554, "protein_name": "Bifunctional epoxide hydrolase 2", "gene_name": "Ephx2", "organism": "Mouse", "refseq_name": "bifunctional epoxide hydrolase 2 isoform c", "refseq_ac": [ { "id": "NP_001258332", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258332", "type": "external" } ], "gene_names_uniprotkb": "Ephx2; Eph2", "gene_names_refseq": "CEH; Eph2; Ephx2; SEH; sEP", "protein_names_uniprotkb": "Bifunctional epoxide hydrolase 2; Epoxide hydratase; SEH; Soluble epoxide hydrolase", "protein_names_refseq": "bifunctional epoxide hydrolase 2 isoform c; bifunctional epoxide hydrolase 2; cytosolic epoxide hydrolase; epoxide hydratase; epoxide hydrolase 2C; soluble epoxide hydrolase", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); familial hypercholesterolemia (Disease Ontology:DOID:13810); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:13850); (R-MMU-2142670); (R-MMU-9018682); (R-MMU-9033241)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10485878;10747889;15601917;17242355;21183079;21217101;23576753;23806337;33300544;34428180;37402372;37453647;38198951;7840649;8349642;8750907", "class_list": "", "function": "Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:21217101, PubMed:7840649). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Bifunctional enzyme. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (By similarity). Has phosphatase activity toward lyso-glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates (By similarity)., [UniProtKB, UniProtKB]; Hepatic soluble epoxide hydrolase activity regulates cerebral Abeta metabolism and the pathogenesis of Alzheimer's disease in mice., [RefSeq, PubMed]; Role of the soluble epoxide hydrolase in keratinocyte proliferation and sensitivity of skin to inflammatory stimuli., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CGV0", "ec_number_list": [ { "id": "3.3.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10", "type": "external" }, { "id": "3.1.3.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.76", "type": "external" }, { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "3.6.1.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.3.2.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9", "type": "external" } ], "go_molecular_function": "GO:0052642 lysophosphatidic acid phosphatase activity;GO:0000287 magnesium ion binding;GO:0015643 toxic substance binding;GO:0042803 protein homodimerization activity;GO:0004301 epoxide hydrolase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0016311 dephosphorylation;GO:0010628 positive regulation of gene expression;GO:0045777 positive regulation of blood pressure;GO:0090181 regulation of cholesterol metabolic process;GO:0043651 linoleic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P34914-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64478-1", "uniprot_id": [ { "id": "H2B1H_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64478", "type": "external" } ], "mass": 13920.0, "length": 126, "protein_name": "Histone H2B type 1-H", "gene_name": "H2bc9", "organism": "Mouse", "refseq_name": "histone H2B type 1-H", "refseq_ac": [ { "id": "NP_835504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_835504", "type": "external" } ], "gene_names_uniprotkb": "H2bc9; Hist1h2bh", "gene_names_refseq": "H2b-221; H2bc9; Hist1h2bh", "protein_names_uniprotkb": "Histone H2B type 1-H; H2B-clustered histone 9; h2B-221", "protein_names_refseq": "histone 1, H2bh; histone H2B type 1-H; histone cluster 1, H2bh", "tax_id": 10090, "disease": "", "pathway": " (mmu:319182); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214847); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-606279); (R-MMU-69473); (R-MMU-8866654); (R-MMU-8936459); (R-MMU-9018519); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 21, "publication_count": 21, "publication_id_list": "12408966;15197225;16039583;20647423;21925322;22389435;24681537;25428506;27105115;28011936;30084848;30154464;30779550;31645732;32152506;32822587;33300544;33725478;35820727;37828378;6314253", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2RTP6;Q3TYR6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000786 nucleosome", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q64478-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2NU22-1", "uniprot_id": [ { "id": "A2NU22_MOUSE", "url": "https://www.uniprot.org/uniprot/A2NU22", "type": "external" } ], "mass": 12247.0, "length": 111, "protein_name": "T cell receptor beta, variable 31", "gene_name": "Trbv31", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trbv31", "gene_names_refseq": "", "protein_names_uniprotkb": "T cell receptor beta, variable 31", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0A6YW81;A0A0U1RVH3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2NU22-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQQ8-1", "uniprot_id": [ { "id": "Q7TQQ8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQQ8", "type": "external" } ], "mass": 35064.0, "length": 314, "protein_name": "Olfactory receptor", "gene_name": "Or5b118", "organism": "Mouse", "refseq_name": "olfactory receptor family 5 subfamily B member 118", "refseq_ac": [ { "id": "NP_001011842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011842", "type": "external" } ], "gene_names_uniprotkb": "Or5b118; Olfr1474", "gene_names_refseq": "MOR202-26P; MOR202-42; Olfr1474; Or5b118", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2RE5P-3803583-3804527; olfactory receptor 1474; olfactory receptor MOR202-26P; olfactory receptor family 5 subfamily B member 118", "tax_id": 10090, "disease": "", "pathway": " (mmu:258123)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TQQ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "L7N255-1", "uniprot_id": [ { "id": "L7N255_MOUSE", "url": "https://www.uniprot.org/uniprot/L7N255", "type": "external" } ], "mass": 24243.0, "length": 205, "protein_name": "Predicted gene 3099", "gene_name": "Gm3099", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm3099", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene 3099", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "L7N255-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JF09-1", "uniprot_id": [ { "id": "A0A0G2JF09_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0G2JF09", "type": "external" } ], "mass": 12638.0, "length": 112, "protein_name": "T cell receptor alpha variable 12D-2; T cell receptor alpha variable 12N-2", "gene_name": "Trav12d-2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trav12d-2; Trav12n-2", "gene_names_refseq": "", "protein_names_uniprotkb": "T cell receptor alpha variable 12D-2; T cell receptor alpha variable 12N-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0042101 T cell receptor complex", "go_biological_process": "GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JF09-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "W4VSP0-1", "uniprot_id": [ { "id": "W4VSP0_MOUSE", "url": "https://www.uniprot.org/uniprot/W4VSP0", "type": "external" } ], "mass": 36528.0, "length": 330, "protein_name": "Olfactory receptor", "gene_name": "Or10al6", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Or10al6; Olfr122", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:258285)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "W4VSP0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11835-1", "uniprot_id": [ { "id": "ITB2_MOUSE", "url": "https://www.uniprot.org/uniprot/P11835", "type": "external" } ], "mass": 85026.0, "length": 771, "protein_name": "Integrin beta-2", "gene_name": "Itgb2", "organism": "Mouse", "refseq_name": "integrin beta-2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_032430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032430", "type": "external" } ], "gene_names_uniprotkb": "Itgb2", "gene_names_refseq": "2E6; Cd18; Itgb2; LAD; LCAMB; Lfa1; MF17", "protein_names_uniprotkb": "Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta", "protein_names_refseq": "Mac-1 beta; cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; complement receptor C3 subunit beta; integrin beta-2 isoform 1 precursor; lymphocyte function associated antigen 1; macrophage antigen-1 beta", "tax_id": 10090, "disease": "leukocyte adhesion deficiency 1 (Disease Ontology:DOID:0110910); nephritis (Disease Ontology:DOID:10952); Vogt-Koyanagi-Harada disease (Disease Ontology:DOID:12297); cancer (Disease Ontology:DOID:162); Epstein-Barr virus infectious disease (Disease Ontology:DOID:2938); coronary restenosis (Disease Ontology:DOID:4247); allergic rhinitis (Disease Ontology:DOID:4481); pneumonia (Disease Ontology:DOID:552); leukocyte adhesion deficiency (Disease Ontology:DOID:6612); myocarditis (Disease Ontology:DOID:820); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (mmu:16414); (R-MMU-166016); (R-MMU-198933); (R-MMU-202733); (R-MMU-216083); (R-MMU-6798695)", "pathway_count": 6, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;1671669;18250455;18587400;1969385;19903482;21750661;2569711;26495903;26740625;28935714;30899004;31219806;33300544;34428180;36210013;39627609", "class_list": "", "function": "Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (By similarity). Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (By similarity). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (By similarity). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (By similarity). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (By similarity). Integrin ITGAM/ITGB2 plays a critical role in mast cell development and in immune complex-mediated glomerulonephritis. Mice expressing a null mutation of the ITGAM subunit gene demonstrate increase in neutrophil accumulation, in response to a impaired degranulation and phagocytosis, events that apparently accelerate apoptosis in neutrophils. These mice develop obesity. Integrins ITGAX:ITGB2 functions as a receptor of the erythrocyte-specific adhesion molecule ICAM4 and mediates erythrophagocytosis. Integrins ITGAX:ITGB2 functions as a receptor of the neuron-specific adhesion molecule ICAM5 ensuring neuron cell-leukocyte adhesion. Integrin ITGAL:ITGB2 functions as a receptor of ICAM1 by acting as a platform at the immunological synapse to translate TCR engagement and density of the ITGAL ligand ICAM1 into graded adhesion. Integrin ITGAM:ITGB2/MAC-1 complex functions as a signaling receptor for the ligand receptor ICAM1, ensuring adhesion between stimulated neutrophils and stimulated endothelial cells. Integrin ITGAL/ITGB2 that functions as a signaling receptor of ICAM2, ensuring leukocyte cell-cell adhesion on resting cells (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 11, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q64482", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0001540 amyloid-beta binding;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0016020 membrane;GO:0043235 receptor complex", "go_biological_process": "GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell;GO:0006911 phagocytosis, engulfment;GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0031623 receptor internalization", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P11835-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C1D8-1", "uniprot_id": [ { "id": "IWS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C1D8", "type": "external" } ], "mass": 85248.0, "length": 766, "protein_name": "Protein IWS1 homolog", "gene_name": "Iws1", "organism": "Mouse", "refseq_name": "protein IWS1 homolog", "refseq_ac": [ { "id": "NP_775617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775617", "type": "external" } ], "gene_names_uniprotkb": "Iws1; Iws1l", "gene_names_refseq": "1700069O15Rik; 3000008H23; Iws1", "protein_names_uniprotkb": "Protein IWS1 homolog; IWS1-like protein", "protein_names_refseq": "IWS1 homolog; IWS1-like protein; protein IWS1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:73473); (R-MMU-112382); (R-MMU-674695); (R-MMU-75955)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;17184735;17242355;19131326;19144319;21183079;21750661;30846735;39627609", "class_list": "", "function": "Iws1 and Spt6 Regulate Trimethylation of Histone H3 on Lysine 36 through Akt Signaling and are Essential for Mouse Embryonic Genome Activation. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 43, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQ25;Q3UWB0;Q6NVD1;Q8BY73;Q9D9H4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0001701 in utero embryonic development;GO:0006338 chromatin remodeling;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8C1D8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60673-1", "uniprot_id": [ { "id": "PTPRN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60673", "type": "external" } ], "mass": 106083.0, "length": 979, "protein_name": "Receptor-type tyrosine-protein phosphatase-like N", "gene_name": "Ptprn", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ptprn; Ptp35", "gene_names_refseq": "", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase-like N; PTP IA-2; R-PTP-N", "protein_names_refseq": "", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); diabetes mellitus (Disease Ontology:DOID:9351); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": "", "pathway_count": 0, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;12031972;12364328;15939893;16269463;18178618;19019914;19361477;21183079;21732083;21750661;21913724;30899004;31599954;33300544;34203471;37828378;7980563;8526904;8878556", "class_list": "", "function": "ICA512-CCF translocated to the nucleus promotes expression of insulin and other granule-related genes; the function implicates binding to and regulating activity of STAT5B probably by preventing its dephosphorylation and potentially by inducing its sumoylation by recruiting PIAS4 (By similarity). Enhances pancreatic beta-cell proliferation by converging with signaling by STAT5B and STAT3 (PubMed:18178618). ICA512-CCF located in the cytoplasm regulates dynamics and exocytosis of insulin secretory granules (SGs) by dimerizing with ICA512-TMF and displacing SNTB2 thus enhancing SGs mobility and exocytosis (By similarity)., [UniProtKB, PubMed, UniProtKB]; ICA512-TMF regulates dynamics and exocytosis of insulin secretory granules (SGs); binding of ICA512-TMF to SNTB2/beta-2-syntrophin is proposed to restrain SGs mobility and exocytosis by tethering them to the actin cytoskeleton depending on UTRN; the function is inhibited by cytoplasmic ICA512-CFF dimerizing with ICA512-TMF and displacing SNTB2 (By similarity)., [UniProtKB, UniProtKB]; Plays a role in vesicle-mediated secretory processes (PubMed:21732083). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:15939893, PubMed:21732083). Plays a role in insulin secretion in response to glucose stimuli (PubMed:12031972, PubMed:21732083). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (PubMed:16269463). In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (PubMed:16269463). Seems to lack intrinsic enzyme activity (PubMed:7980563, PubMed:8878556). Required to maintain normal levels of renin expression and renin release (PubMed:19019914). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (PubMed:12364328)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9Q746;Q62129", "ec_number_list": [], "go_molecular_function": "GO:0030507 spectrin binding;GO:0051020 GTPase binding;GO:0044389 ubiquitin-like protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030141 secretory granule", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000302 response to reactive oxygen species;GO:0051046 regulation of secretion;GO:0001553 luteinization", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q60673-1", "record_type": "protein", "filter_code": "0000000.0100110.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B9EKR1-1", "uniprot_id": [ { "id": "PTPRZ_MOUSE", "url": "https://www.uniprot.org/uniprot/B9EKR1", "type": "external" } ], "mass": 254405.0, "length": 2312, "protein_name": "Receptor-type tyrosine-protein phosphatase zeta", "gene_name": "Ptprz1", "organism": "Mouse", "refseq_name": "receptor-type tyrosine-protein phosphatase zeta isoform 3 precursor", "refseq_ac": [ { "id": "NP_001074775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074775", "type": "external" } ], "gene_names_uniprotkb": "Ptprz1", "gene_names_refseq": "DSD-1-PG; PTPbeta; PTPzeta; Ptprz1; Ptprz; Ptpz; R-PTP-zeta; RPTPz; Rptpbeta", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase zeta; 3.1.3.48; R-PTP-zeta", "protein_names_refseq": "3F8 chondroitin sulfate proteoglycan; 3H1 keratan sulfate proteoglycan; phosphacan; receptor-type tyrosine-protein phosphatase zeta isoform 3 precursor; receptor-type tyrosine-protein phosphatase zeta", "tax_id": 10090, "disease": "status epilepticus (Disease Ontology:DOID:1824); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); gastric adenocarcinoma (Disease Ontology:DOID:3717)", "pathway": " (mmu:19283); (R-MMU-449836); (R-MMU-9851151)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11003666;12355066;16513268;20133774;21183079;21750661;21969550;22645316;30899004;33300544;34428180;36210013;40885482;9655611", "class_list": "glycogene", "function": "Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 12, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 12, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 12, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 127, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 30, "disease_count": 5, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0005178 integrin binding;GO:0017134 fibroblast growth factor binding;GO:0016791 phosphatase activity;GO:0004725 protein tyrosine phosphatase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0030424 axon", "go_biological_process": "GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0007165 signal transduction;GO:0007409 axonogenesis;GO:0007611 learning or memory;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 5.9, "record_id": "B9EKR1-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000011001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1Z7-1", "uniprot_id": [ { "id": "PTPS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1Z7", "type": "external" } ], "mass": 16188.0, "length": 144, "protein_name": "6-pyruvoyl tetrahydrobiopterin synthase", "gene_name": "Pts", "organism": "Mouse", "refseq_name": "6-pyruvoyl tetrahydrobiopterin synthase isoform 1", "refseq_ac": [ { "id": "NP_035350", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035350", "type": "external" } ], "gene_names_uniprotkb": "Pts", "gene_names_refseq": "PTPS; Pts", "protein_names_uniprotkb": "6-pyruvoyl tetrahydrobiopterin synthase; 4.2.3.12; PTP synthase; PTPS", "protein_names_refseq": "6-pyruvoyl tetrahydrobiopterin synthase isoform 1; 6-pyruvoyl tetrahydrobiopterin synthase; PTP synthase", "tax_id": 10090, "disease": "BH4-deficient hyperphenylalaninemia A (Disease Ontology:DOID:0090106); phenylketonuria (Disease Ontology:DOID:9281)", "pathway": " (mmu:19286); (R-MMU-1474151)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12734191;21062748;21183079;21750661;30084848;9894812", "class_list": "", "function": "Biopterin contents in the brains of these knock-out mice were moderately decreased from postnatal day 0 (P0) and remained constant up to P21, [RefSeq, PubMed]; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Ptps has a role in 6-pyruvoyltetrahydropterin synthase- or BH4-biosynthetic activity with IGF-1, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UIB6;Q9Z2N2", "ec_number_list": [ { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "4.2.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.3.12", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0003874 6-pyruvoyltetrahydropterin synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006729 tetrahydrobiopterin biosynthetic process;GO:0046146 tetrahydrobiopterin metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9R1Z7-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62136-1", "uniprot_id": [ { "id": "PTN21_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62136", "type": "external" } ], "mass": 133491.0, "length": 1176, "protein_name": "Tyrosine-protein phosphatase non-receptor type 21", "gene_name": "Ptpn21", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ptpn21", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 21; 3.1.3.48; Protein-tyrosine phosphatase PTP-RL10", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:24000)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17242355;21183079;21750661;31219806;34428180;35820727;7838537", "class_list": "", "function": "May be involved in the regulation of growth and differentiation of liver cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005737 cytoplasm", "go_biological_process": "GO:0035332 positive regulation of hippo signaling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62136-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61136-1", "uniprot_id": [ { "id": "PRP4K_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61136", "type": "external" } ], "mass": 116976.0, "length": 1007, "protein_name": "Serine/threonine-protein kinase PRP4 homolog", "gene_name": "Prp4k; Prpf4b", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase PRP4 homolog", "refseq_ac": [ { "id": "NP_038858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038858", "type": "external" } ], "gene_names_uniprotkb": "Prp4k; Prpf4b; Cbp143; Prp4h; Prp4m; Prpf4b; Prpk", "gene_names_refseq": "2610037H07; Prp4k; Prp4; Prpf4b; Prpk; cbp143", "protein_names_uniprotkb": "Serine/threonine-protein kinase PRP4 homolog; 2.7.11.1; PRP4 pre-mRNA-processing factor 4 homolog; Pre-mRNA protein kinase", "protein_names_refseq": "PRP4 pre-mRNA processing factor 4 homolog B; PRP4 pre-mRNA-processing factor 4 homolog; pre-mRNA protein kinase; serine/threonine-protein kinase PRP4 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:19134); (R-MMU-72163)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "12077342;15592455;17242355;17947660;18034455;19131326;21183079;21750661;23806337;25428506;29187734;34428180;9102632;9701556", "class_list": "", "function": "Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes., [RefSeq, PubMed]; Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation. Connects chromatin mediated regulation of transcription and pre-mRNA splicing. During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation. Associates and probably phosphorylates SMARCA4 and NCOR1. Phosphorylates SRSF1. Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores. Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13. Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 37, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RUN6;O88378;Q8BND8;Q8R4Y5;Q9CTL9;Q9CTT0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0000776 kinetochore;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0046827 positive regulation of protein export from nucleus;GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint;GO:0000387 spliceosomal snRNP assembly;GO:0035332 positive regulation of hippo signaling", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q61136-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PYL2-1", "uniprot_id": [ { "id": "PRR12_MOUSE", "url": "https://www.uniprot.org/uniprot/E9PYL2", "type": "external" } ], "mass": 211876.0, "length": 2035, "protein_name": "Proline-rich protein 12", "gene_name": "Prr12", "organism": "Mouse", "refseq_name": "proline-rich protein 12", "refseq_ac": [ { "id": "NP_778187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778187", "type": "external" } ], "gene_names_uniprotkb": "Prr12; Kiaa1205", "gene_names_refseq": "6720469B10; Prr12", "protein_names_uniprotkb": "Proline-rich protein 12", "protein_names_refseq": "proline-rich protein 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:233210)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "17242355;19144319;21183079;25605945;26163108;26992070;30059200;31219806;33725478;34428180;35820727;39742660;40885482;40997131", "class_list": "", "function": "May play a role in the regulation of cohesin complex loading onto chromatin, probably acting in coordination with NIPBL and MAU2., [UniProtKB, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZN8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0014069 postsynaptic density;GO:0043005 neuron projection", "go_biological_process": "GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "E9PYL2-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48437-1", "uniprot_id": [ { "id": "PROX1_MOUSE", "url": "https://www.uniprot.org/uniprot/P48437", "type": "external" } ], "mass": 83126.0, "length": 737, "protein_name": "Prospero homeobox protein 1", "gene_name": "Prox1", "organism": "Mouse", "refseq_name": "prospero homeobox protein 1", "refseq_ac": [ { "id": "NP_032963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032963", "type": "external" } ], "gene_names_uniprotkb": "Prox1", "gene_names_refseq": "A230003G05Rik; PROX-1; Prox1", "protein_names_uniprotkb": "Prospero homeobox protein 1; Homeobox prospero-like protein PROX1; PROX-1", "protein_names_refseq": "homeobox prospero-like protein PROX1; prospero homeobox protein 1; prospero-related homeobox 1", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); brain cancer (Disease Ontology:DOID:1319); cancer (Disease Ontology:DOID:162); status epilepticus (Disease Ontology:DOID:1824); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:19130)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17203969;17242355;18630941;21183079;22733308;23723244;28179430;7908825;9703987", "class_list": "", "function": "Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88478;Q3UPV1;Q543D8", "ec_number_list": [], "go_molecular_function": "GO:0050693 LBD domain binding;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0060214 endocardium formation;GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0072574 hepatocyte proliferation;GO:0046619 lens placode formation involved in camera-type eye formation;GO:0055005 ventricular cardiac myofibril assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P48437-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80560-1", "uniprot_id": [ { "id": "PTPR2_MOUSE", "url": "https://www.uniprot.org/uniprot/P80560", "type": "external" } ], "mass": 111497.0, "length": 1001, "protein_name": "Receptor-type tyrosine-protein phosphatase N2", "gene_name": "Ptprn2", "organism": "Mouse", "refseq_name": "receptor-type tyrosine-protein phosphatase N2 precursor", "refseq_ac": [ { "id": "NP_035345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035345", "type": "external" } ], "gene_names_uniprotkb": "Ptprn2", "gene_names_refseq": "4930425H11Rik; IA2beta; PTP-NP; Phol; Ptprn2; mKIAA0387; phogrin", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase N2; 3.1.3.-; 3.1.3.48; PTP IA-2beta; PTP-NP; Phogrin; Protein tyrosine phosphatase-NP; R-PTP-N2", "protein_names_refseq": "IA-2 beta; PTP IA-2beta; R-PTP-N2; protein tyrosine phosphatase-NP; receptor-type tyrosine-protein phosphatase N2 precursor; receptor-type tyrosine-protein phosphatase N2", "tax_id": 10090, "disease": "prediabetes syndrome (Disease Ontology:DOID:11716); Parkinson's disease (Disease Ontology:DOID:14330); diabetes mellitus (Disease Ontology:DOID:9351); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:19276); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;12364328;15220191;15485654;16262730;16269463;16418280;17114649;17611635;19019914;19361477;21183079;21210912;21544547;21732083;24129315;26148972;26495903;29483197;35820727;38150052;8637868;8681804", "class_list": "", "function": "Data show that miRNAs are involved in regulating the expression of the major type 1 diabetes (T1D) autoantigens IA-2, IA-2beta, and GAD65 enzyme., [RefSeq, PubMed]; Insulin granule morphology and crinosome formation in mice lacking the pancreatic beta cell-specific phogrin (PTPRN2) gene., [RefSeq, PubMed]; Plays a role in vesicle-mediated secretory processes (PubMed:21732083). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:21732083). Plays a role in insulin secretion in response to glucose stimuli (PubMed:15220191, PubMed:16418280, PubMed:21732083). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (PubMed:16269463). Required to maintain normal levels of renin expression and renin release (PubMed:19019914). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (PubMed:12364328). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolysis of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Relative to wildtype mice, IRS2 levels in phogrin-knockout mice islets decreased by 44%. When phogrin was silenced by shRNA in pancreatic beta-cell lines, glucose-induced insulin signaling led to proteasomal degradation of IRS2 via a negative feedback mechanism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 3, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O09134;P70328;Q1RLJ1", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0030141 secretory granule;GO:0043195 terminal bouton;GO:0043235 receptor complex;GO:0045202 synapse", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0034260 negative regulation of GTPase activity;GO:0007269 neurotransmitter secretion;GO:0051046 regulation of secretion;GO:0035773 insulin secretion involved in cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P80560-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2EY15-1", "uniprot_id": [ { "id": "PRTG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q2EY15", "type": "external" } ], "mass": 130533.0, "length": 1191, "protein_name": "Protogenin", "gene_name": "Prtg", "organism": "Mouse", "refseq_name": "protogenin precursor", "refseq_ac": [ { "id": "NP_780694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780694", "type": "external" } ], "gene_names_uniprotkb": "Prtg", "gene_names_refseq": "A230098A12Rik; Igdcc5; Prtg", "protein_names_uniprotkb": "Protogenin; Protein Shen-Dan", "protein_names_refseq": "protein Shen-Dan; protogenin homolog (Gallus gallus); protogenin precursor; shen-dan", "tax_id": 10090, "disease": "", "pathway": " (mmu:235472)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16881056", "class_list": "", "function": "May play a role in anteroposterior axis elongation., [UniProtKB, PubMed]; Protogenin expression is restricted to posterior neural plate and mesoderm, with an anterior limit at the level of the rhombencephalon., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A4FUS8;A4FUS9;Q2VWP8;Q8BJK6;Q8BYL5", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0098632 cell-cell adhesion mediator activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007411 axon guidance;GO:0050768 negative regulation of neurogenesis;GO:0070593 dendrite self-avoidance", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2EY15-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2PFD7-1", "uniprot_id": [ { "id": "PSD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q2PFD7", "type": "external" } ], "mass": 114722.0, "length": 1037, "protein_name": "PH and SEC7 domain-containing protein 3", "gene_name": "Psd3", "organism": "Mouse", "refseq_name": "PH and SEC7 domain-containing protein 3 isoform 3", "refseq_ac": [ { "id": "NP_081902", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081902", "type": "external" } ], "gene_names_uniprotkb": "Psd3; Efa6d; Kiaa0942", "gene_names_refseq": "4931420C21Rik; D430018P08; EFA6D; Psd3", "protein_names_uniprotkb": "PH and SEC7 domain-containing protein 3; Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 D; Exchange factor for ARF6 D; Pleckstrin homology and SEC7 domain-containing protein 3", "protein_names_refseq": "PH and SEC7 domain-containing protein 3 isoform 3; PH and SEC7 domain-containing protein 3; exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 D; exchange factor for ARF6 D; guanine nucleotide exchange factor for ADP ribosylation factor 6; pleckstrin homology and SEC7 domain-containing protein 3", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:234353)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;15345747;16452087;16707115;17242355;21183079;21750661;22517741;22645316;23603394;27241101;31219806;34428180;35102341;40021952;40885482", "class_list": "", "function": "Genetic variants of EFA6D were found to be distributed in overlapping patterns throughout the subcellular brain., [RefSeq, PubMed]; Guanine nucleotide exchange factor for ARF6., [UniProtKB, PubMed]; PSD3 downregulation confers protection against fatty liver disease., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTA1;Q80TN6;Q80UZ7;Q8CEA6", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0005543 phospholipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0014069 postsynaptic density;GO:0016020 membrane;GO:0098794 postsynapse;GO:0032587 ruffle membrane", "go_biological_process": "GO:0032011 ARF protein signal transduction;GO:0016192 vesicle-mediated transport;GO:0032012 regulation of ARF protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q2PFD7-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99M80-1", "uniprot_id": [ { "id": "PTPRT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99M80", "type": "external" } ], "mass": 163012.0, "length": 1454, "protein_name": "Receptor-type tyrosine-protein phosphatase T", "gene_name": "Ptprt", "organism": "Mouse", "refseq_name": "receptor-type tyrosine-protein phosphatase T isoform a precursor", "refseq_ac": [ { "id": "NP_001278078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278078", "type": "external" } ], "gene_names_uniprotkb": "Ptprt", "gene_names_refseq": "Ptprt; R-PTP-T; RPTP-rfo; RPTP-rho; RPTPmam4; RPTPrho; mKIAA0283; mRPTPrho", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase T; 3.1.3.48; R-PTP-T; RPTP-rho; RPTPmam4; Receptor-type tyrosine-protein phosphatase rho; mRPTPrho", "protein_names_refseq": "receptor protein tyrosine phosphatase-rho; receptor-type tyrosine-protein phosphatase T isoform a precursor; receptor-type tyrosine-protein phosphatase T; receptor-type tyrosine-protein phosphatase rho", "tax_id": 10090, "disease": "esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:19281)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;11423001;21183079;21750661;33300544;36583697;9486824", "class_list": "", "function": "ADAM10- and gamma-secretase-dependent cleavage of the transmembrane protein PTPRT attenuates neurodegeneration in the mouse model of Alzheimer's disease., [RefSeq, PubMed]; May be involved in both signal transduction and cellular adhesion in the CNS. May have specific signaling roles in the tyrosine phosphorylation/dephosphorylation pathway in the anterior compartment of the adult cerebellar cortex., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 2, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q99M81;Q99M82;Q9JIZ1;Q9JIZ2;Q9JKC2;Q9JLP0", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0097677 STAT family protein binding;GO:0042803 protein homodimerization activity;GO:0051393 alpha-actinin binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0098839 postsynaptic density membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0031175 neuron projection development;GO:0030336 negative regulation of cell migration;GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q99M80-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CIE6-1", "uniprot_id": [ { "id": "COPA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CIE6", "type": "external" } ], "mass": 138432.0, "length": 1224, "protein_name": "Coatomer subunit alpha", "gene_name": "Copa", "organism": "Mouse", "refseq_name": "coatomer subunit alpha", "refseq_ac": [ { "id": "NP_034068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034068", "type": "external" } ], "gene_names_uniprotkb": "Copa", "gene_names_refseq": "Copa; xenin", "protein_names_uniprotkb": "Coatomer subunit alpha; Alpha-COP; Alpha-coat protein; Xenopsin-related peptide", "protein_names_refseq": "alpha-COP; alpha-coat protein; coatomer subunit alpha", "tax_id": 10090, "disease": "autoimmune interstitial lung, joint, and kidney disease (Disease Ontology:DOID:0081242)", "pathway": " (mmu:12847); (R-MMU-6807878); (R-MMU-6811434)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;16452087;18299400;21183079;21750661;21952136;22872234;26495903;29187734;31219806;32769216;33300544;34428180;34887587;36210013;36792666;37453647;37507081;39627609", "class_list": "", "function": "Individual and combined effects of GIP and xenin on differentiation, glucose uptake and lipolysis in 3T3-L1 adipocytes., [RefSeq, PubMed]; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9Q075", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005198 structural molecule activity;GO:0005179 hormone activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0030424 axon", "go_biological_process": "GO:0099612 protein localization to axon;GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0030157 pancreatic juice secretion;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q8CIE6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CS84-1", "uniprot_id": [ { "id": "NRX1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CS84", "type": "external" } ], "mass": 166169.0, "length": 1514, "protein_name": "Neurexin-1", "gene_name": "Nrxn1", "organism": "Mouse", "refseq_name": "neurexin-1 isoform 8", "refseq_ac": [ { "id": "NP_001333891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333891", "type": "external" } ], "gene_names_uniprotkb": "Nrxn1; Kiaa0578", "gene_names_refseq": "1700062G21Rik; 9330127H16Rik; A230068P09Rik; Nrxn1; mKIAA0578", "protein_names_uniprotkb": "Neurexin-1; Neurexin I-alpha; Neurexin-1-alpha", "protein_names_refseq": "alpha-latrotoxin receptor (calcium-dependent); neurexin 1 NRXN1+7a; neurexin 1 NRXN1-7; neurexin-1 isoform 8; neurexin-1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); Pitt-Hopkins-like syndrome 2 (Disease Ontology:DOID:0111332); transient cerebral ischemia (Disease Ontology:DOID:224); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:18189); (R-MMU-6794361)", "pathway_count": 2, "publication_count": 31, "publication_id_list": "10.1101/2023.09.13.557529;10408888;11171101;11243866;12827191;14983056;16406382;17035546;17347997;18334216;18434543;19822762;20624592;21410790;21750661;22196734;22220752;24094106;24613359;25385611;25737549;29782851;30100184;30899004;31219806;32434929;33300544;34135511;35820727;40885482;9430716", "class_list": "", "function": "Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may affect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Findings uncover SAM68 as a key regulator of dynamic control of Nrxn1 molecular diversity and activity-dependent alternative splicing in the central nervous system., [RefSeq, PubMed]; Neuronal cell surface protein involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins (By similarity). Plays a role in formation of synaptic junctions (PubMed:30100184). Functions as part of a trans-synaptic complex by binding to cerebellins and postsynaptic GRID1. This interaction helps regulate the activity of NMDA and AMPA receptors at hippocampal synapses without affecting synapse formation. NRXN1B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic NMDAR response (PubMed:34135511)., [UniProtKB, UniProtKB, PubMed, PubMed]; This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. In vertebrates, alternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. Mouse knockouts display decreased spontaneous and evoked vesicle release resulting in impaired synaptic transmission. In addition, knockout mice show altered social approach, reduced social investigation, reduced locomotor activity, and in males, increased aggression. Alternative splicing and promoter usage result in multiple transcript variants. [provided by RefSeq, Nov 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "G3UWZ9;O88722;Q80Y87;Q8CHE6", "ec_number_list": [], "go_molecular_function": "GO:0005105 type 1 fibroblast growth factor receptor binding;GO:0004888 transmembrane signaling receptor activity;GO:0005102 signaling receptor binding;GO:0033130 acetylcholine receptor binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0099054 presynapse assembly;GO:0097116 gephyrin clustering involved in postsynaptic density assembly;GO:0097104 postsynaptic membrane assembly;GO:0007165 signal transduction;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "Q9CS84-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27671-1", "uniprot_id": [ { "id": "RGRF1_MOUSE", "url": "https://www.uniprot.org/uniprot/P27671", "type": "external" } ], "mass": 144102.0, "length": 1262, "protein_name": "Ras-specific guanine nucleotide-releasing factor 1", "gene_name": "Rasgrf1", "organism": "Mouse", "refseq_name": "ras-specific guanine nucleotide-releasing factor 1 isoform 1", "refseq_ac": [ { "id": "NP_035375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035375", "type": "external" } ], "gene_names_uniprotkb": "Rasgrf1; Cdc25; Grf1", "gene_names_refseq": "CDC25Mm; CDC25; Gnrp; Grf1; Grfbeta; P190-A; Ras-GRF1; Rasgrf1; p190RhoGEF; p190", "protein_names_uniprotkb": "Ras-specific guanine nucleotide-releasing factor 1; CDC25Mm; GNRP; Guanine nucleotide-releasing protein; Ras-GRF1; Ras-specific nucleotide exchange factor CDC25", "protein_names_refseq": "Ras guanine release factor beta; ras-specific guanine nucleotide-releasing factor 1 isoform 1; ras-specific guanine nucleotide-releasing factor 1; ras-specific nucleotide exchange factor CDC25", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (mmu:19417); (R-MMU-5673001)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10373510;11018028;11500497;1376246;1379731;1396590;21183079;21750661;25428506;34418053;34428180;34678516;35422804;36098964;40885482", "class_list": "", "function": "Expression of a RhoA-Specific Guanine Nucleotide Exchange Factor, p190RhoGEF, in Mouse Macrophages Negatively Affects M1 Polarization and Inflammatory Responses. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of MLL Induces Epigenetic Dysregulation of Rasgrf1 to Attenuate Kras-Driven Lung Tumorigenesis., [RefSeq, PubMed]; Promotes the exchange of Ras-bound GDP by GTP., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0030971 receptor tyrosine kinase binding;GO:0035254 glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030426 growth cone", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0008283 cell population proliferation;GO:0031175 neuron projection development;GO:0043410 positive regulation of MAPK cascade;GO:0043547 positive regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P27671-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47199-1", "uniprot_id": [ { "id": "QOR_MOUSE", "url": "https://www.uniprot.org/uniprot/P47199", "type": "external" } ], "mass": 35269.0, "length": 331, "protein_name": "Zeta-crystallin", "gene_name": "Cryz", "organism": "Mouse", "refseq_name": "zeta-crystallin", "refseq_ac": [ { "id": "NP_034098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034098", "type": "external" } ], "gene_names_uniprotkb": "Cryz", "gene_names_refseq": "Cryz; Sez9", "protein_names_uniprotkb": "Zeta-crystallin; 1.6.5.5; NADPH:quinone reductase; Quinone oxidoreductase", "protein_names_refseq": "NADPH:quinone reductase; quinone oxidoreductase; zeta-crystallin", "tax_id": 10090, "disease": "", "pathway": " (mmu:12972)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "19657324;21183079;21750661;23576753;23806337;32914211;34418053;34428180;37453647;8170370;8645260", "class_list": "", "function": "Activation of farnesoid X receptor (FXR) induces crystallin zeta expression in mouse medullary collecting duct cells., [RefSeq, PubMed]; Induction of zeta-crystallin by an acid pH plays an important role in preventing BSC1 mRNA decay, [RefSeq, PubMed]; Multifunctional crystallin endowed with unrelated mRNA stabilization and enzymatic oxidoreductase activities. Binds (AU)-rich elements (ARE) in the 3'-UTR of target mRNA to enhance their stability. Upon metabolic acidosis, stabilizes the mRNA encoding SLC12A1 a cotransporter involved in transepithelial NH4(+) reabsorption in the medullary thick ascending limb in kidney. In response to acidosis, also participates to the adaptive increase in renal ammoniagenesis by stabilizing the mRNAs of enzymes involved in glutamine catabolism. By the same mechanism, it also regulates the expression of the antiapoptotic protein BCL2. Beside its mRNA stabilization activity, also catalyzes the reduction of orthoquinones such as 1,2-naphthoquinone or 9,10-phenanthrenequinone in the presence of NADPH in vitro and could be involved in the detoxification of xenobiotics and protection against oxidative stress., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q62508;Q99L63", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003960 quinone reductase (NADPH) activity;GO:0003730 mRNA 3'-UTR binding;GO:0070402 NADPH binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0048255 mRNA stabilization;GO:0051289 protein homotetramerization;GO:0042178 xenobiotic catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P47199-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C2B3-1", "uniprot_id": [ { "id": "HDAC7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C2B3", "type": "external" } ], "mass": 101287.0, "length": 938, "protein_name": "Histone deacetylase 7", "gene_name": "Hdac7", "organism": "Mouse", "refseq_name": "histone deacetylase 7 isoform 1", "refseq_ac": [ { "id": "NP_001191204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191204", "type": "external" } ], "gene_names_uniprotkb": "Hdac7; Hdac7a", "gene_names_refseq": "5830434K02Rik; HD7a; HD7; Hdac7a; Hdac7; mFLJ00062", "protein_names_uniprotkb": "Histone deacetylase 7; 3.5.1.-; 3.5.1.98; HD7a; HD7; Histone deacetylase 7A; Protein deacetylase HDAC7", "protein_names_refseq": "histone deacetylase 7 isoform 1; histone deacetylase 7A; protein deacetylase HDAC7", "tax_id": 10090, "disease": "colorectal cancer (Disease Ontology:DOID:9256); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (mmu:56233); (R-MMU-3108214); (R-MMU-350054)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10640276;10984530;11279209;11509672;11585834;17242355;18509061;19696312;20621129;20675388;21183079;21750661;31219806;37947442;38657041", "class_list": "", "function": "Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation., [RefSeq, PubMed]; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; SIKs Regulate HDAC7 Stabilization and Cytokine Recall in Late-Stage T Cell Effector Differentiation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2C9;Q8C8X4;Q8CB80;Q8CDA3;Q9JL72", "ec_number_list": [ { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.5.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.48", "type": "external" }, { "id": "3.5.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.62", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0032703 negative regulation of interleukin-2 production;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001570 vasculogenesis;GO:0006351 DNA-templated transcription;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8C2B3-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2A7-1", "uniprot_id": [ { "id": "INT10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2A7", "type": "external" } ], "mass": 82020.0, "length": 710, "protein_name": "Integrator complex subunit 10", "gene_name": "Ints10", "organism": "Mouse", "refseq_name": "integrator complex subunit 10 isoform 1", "refseq_ac": [ { "id": "NP_001280720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001280720", "type": "external" } ], "gene_names_uniprotkb": "Ints10", "gene_names_refseq": "4921521J11Rik; Ints10", "protein_names_uniprotkb": "Integrator complex subunit 10; Int10", "protein_names_refseq": "int10; integrator complex subunit 10 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70885); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21183079;21750661;25428506;30084848;33649389;34428180", "class_list": "", "function": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS10 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters. May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BYC2;Q8BZI9;Q9D5U1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0032039 integrator complex;GO:0160232 INTAC complex", "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0016180 snRNA processing;GO:0160240 RNA polymerase II transcription initiation surveillance", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K2A7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25425-1", "uniprot_id": [ { "id": "PO2F1_MOUSE", "url": "https://www.uniprot.org/uniprot/P25425", "type": "external" } ], "mass": 79547.0, "length": 770, "protein_name": "POU domain, class 2, transcription factor 1", "gene_name": "Pou2f1", "organism": "Mouse", "refseq_name": "POU domain, class 2, transcription factor 1 isoform A", "refseq_ac": [ { "id": "NP_035267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035267", "type": "external" } ], "gene_names_uniprotkb": "Pou2f1; Oct-1; Otf-1; Otf1", "gene_names_refseq": "2810482H01Rik; NF-A1; Oct-1; Oct1; Otf-1; Otf1; Pou2f1", "protein_names_uniprotkb": "POU domain, class 2, transcription factor 1; NF-A1; OTF-1; Oct-1; Octamer-binding protein 1; Octamer-binding transcription factor 1", "protein_names_refseq": "POU domain, class 2, transcription factor 1 isoform A; octamer-binding protein 1; octamer-binding transcription factor 1; ubiquitous transcription factor", "tax_id": 10090, "disease": "immune system disease (Disease Ontology:DOID:2914)", "pathway": " (mmu:18986); (R-MMU-6807505); (R-MMU-76071)", "pathway_count": 3, "publication_count": 23, "publication_id_list": "10023087;11683265;12151092;14729276;1561098;1970171;20173027;21750661;23580612;25428506;32782141;34428180;34887587;35538282;36084651;36374849;36852467;37071732;40128797;40997131;7711063;8376772;8441632", "class_list": "", "function": "5-Azacytidine Suppresses the Expression of Tissue-Specific Oct-1 Isoform in Namalwa Burkitt's Lymphoma Cell Culture., [RefSeq, PubMed]; Exercise training attenuates angiotensin II-induced cardiac fibrosis by reducing POU2F1 expression., [RefSeq, PubMed]; Oct1 cooperates with the Smad family of transcription factors to promote mesodermal lineage specification., [RefSeq, PubMed]; Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q61994;Q63891;Q6Y681;Q7TSD0;Q8BT04;Q8K570;Q99JH0;Q9WTZ4;Q9WTZ5;Q9WTZ6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005667 transcription regulator complex;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0060235 lens induction in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P25425-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SW19-1", "uniprot_id": [ { "id": "CLU_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SW19", "type": "external" } ], "mass": 148068.0, "length": 1315, "protein_name": "Clustered mitochondria protein homolog", "gene_name": "Cluh", "organism": "Mouse", "refseq_name": "clustered mitochondria protein homolog isoform 1", "refseq_ac": [ { "id": "NP_001074627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074627", "type": "external" } ], "gene_names_uniprotkb": "Cluh; Kiaa0664", "gene_names_refseq": "1300001I01Rik; Cluh; Kiaa0664; mKIAA0664", "protein_names_uniprotkb": "Clustered mitochondria protein homolog", "protein_names_refseq": "clustered mitochondria (cluA/CLU1) homolog; clustered mitochondria protein homolog isoform 1; clustered mitochondria protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:74148)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22872234;30084848;31219806;32149416;34203471;34428180;35652974;36210013;37923788;38809982;39927985", "class_list": "", "function": "CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy., [RefSeq, PubMed]; CLUH maintains functional mitochondria and translation in motoneuronal axons and prevents peripheral neuropathy., [RefSeq, PubMed]; Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA. Publication Status: Online-Only, [RefSeq, PubMed]; Plant mitochondrial FMT and its mammalian homolog CLUH controls development and behavior in Arabidopsis and locomotion in mice. Publication Status: Online-Only, [RefSeq, PubMed]; mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A8Y5E2;Q3U014;Q3U4M5;Q3V3Q8;Q505Q6;Q6GQX1;Q6PAT1;Q8CHD9", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0048312 intracellular distribution of mitochondria", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q5SW19-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61144-1", "uniprot_id": [ { "id": "PSN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61144", "type": "external" } ], "mass": 49983.0, "length": 448, "protein_name": "Presenilin-2", "gene_name": "Psen2", "organism": "Mouse", "refseq_name": "presenilin-2 isoform 1", "refseq_ac": [ { "id": "NP_001122077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122077", "type": "external" } ], "gene_names_uniprotkb": "Psen2; Ad4h; Alg3; Ps-2; Ps2; Psnl2", "gene_names_refseq": "ALG-3; Ad4h; Alg3; PS-2; PS2; Psen2; Psnl2; STM2", "protein_names_uniprotkb": "Presenilin-2; 3.4.23.-; PS-2", "protein_names_refseq": "presenilin-2 isoform 1", "tax_id": 10090, "disease": "early-onset Parkinson's disease (Disease Ontology:DOID:0060894); Alzheimer's disease 4 (Disease Ontology:DOID:0110040); Alzheimer's disease 3 (Disease Ontology:DOID:0110042); dilated cardiomyopathy 1V (Disease Ontology:DOID:0110427); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); dilated cardiomyopathy (Disease Ontology:DOID:12930); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (mmu:19165); (R-MMU-1251985); (R-MMU-193692); (R-MMU-205043); (R-MMU-3928665); (R-MMU-9013507); (R-MMU-9017802); (R-MMU-9839383)", "pathway_count": 8, "publication_count": 11, "publication_id_list": "16959576;17242355;19144319;19573580;19834068;21183079;21750661;24788674;34428180;8560270;8940094", "class_list": "", "function": "Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Selectively cleaves late endosomal/lysosomal localized substrates and generates the prominent pool of intracellular amyloid beta that contains longer amyloid beta. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; Egr-1 over-expression and down-regulation, as well as in-vivo examination of Egr-1 and Psen2 expression during fear conditioning, showed that Egr-1 does not regulate the Psen2 promoter., [RefSeq, PubMed]; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors., [UniProtKB, UniProtKB]; This gene encodes a member of the presenilin family. Presenilins are catalytic components of the multi-subunit gamma-secretase complex, which mediates critical cellular processes through cleavage of type I transmembrane proteins including Notch receptors and the amyloid precursor protein. The encoded protein contains eight transmembrane domains and is localized to the endoplasmic reticulum, where it may play a role in calcium homeostasis. Following assembly of the gamma-secretase complex, the encoded protein is cleaved into N- and C-terminal fragments and the activated complex is released from the endoplasmic reticulum. Inactivation of this gene results in impaired synaptic function in a mouse model for Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2011]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O54977;P97934;P97935;Q91VS3;Q9D616", "ec_number_list": [ { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0042500 aspartic endopeptidase activity, intramembrane cleaving", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0002573 myeloid leukocyte differentiation;GO:0001708 cell fate specification;GO:0035333 Notch receptor processing, ligand-dependent;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006509 membrane protein ectodomain proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q61144-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35206-1", "uniprot_id": [ { "id": "COFA1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35206", "type": "external" } ], "mass": 140472.0, "length": 1367, "protein_name": "Collagen alpha-1(XV) chain", "gene_name": "Col15a1", "organism": "Mouse", "refseq_name": "collagen alpha-1(XV) chain precursor", "refseq_ac": [ { "id": "NP_034058", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034058", "type": "external" } ], "gene_names_uniprotkb": "Col15a1", "gene_names_refseq": "Col15a1", "protein_names_uniprotkb": "Collagen alpha-1(XV) chain; Endostatin-XV", "protein_names_refseq": "collagen alpha-1(XV) chain precursor; collagen alpha-1(XV) chain; procollagen type XV; type XV collagen", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); dilated cardiomyopathy (Disease Ontology:DOID:12930); myopathy (Disease Ontology:DOID:423); mitochondrial myopathy (Disease Ontology:DOID:699)", "pathway": " (mmu:12819); (R-MMU-1442490); (R-MMU-1650814); (R-MMU-2022090); (R-MMU-8948216)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10966814;11068203;11158616;17324935;21750661;28011936;30084848;31599954;34576139;9339358;9501087", "class_list": "", "function": "Deletion of Col15a1 Modulates the Tumour Extracellular Matrix and Leads to Increased Tumour Growth in the MMTV-PyMT Mouse Mammary Carcinoma Model. Publication Status: Online-Only, [RefSeq, PubMed]; Restin potently inhibits angiogenesis., [UniProtKB, UniProtKB, UniProtKB]; Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 14, "predicted_n_glycosites": 8, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "A2AJY3;Q3UZ71;Q9EQD9", "ec_number_list": [], "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O35206-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88544-1", "uniprot_id": [ { "id": "CSN4_MOUSE", "url": "https://www.uniprot.org/uniprot/O88544", "type": "external" } ], "mass": 46285.0, "length": 406, "protein_name": "COP9 signalosome complex subunit 4", "gene_name": "Cops4", "organism": "Mouse", "refseq_name": "COP9 signalosome complex subunit 4 isoform a", "refseq_ac": [ { "id": "NP_036131", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036131", "type": "external" } ], "gene_names_uniprotkb": "Cops4; Csn4", "gene_names_refseq": "Cops4; D5Ertd774e; SGN4", "protein_names_uniprotkb": "COP9 signalosome complex subunit 4; JAB1-containing signalosome subunit 4; SGN4; Signalosome subunit 4", "protein_names_refseq": "COP9 (constitutive photomorphogenic) homolog, subunit 4; COP9 (constitutive photomorphogenic), subunit 4; COP9 complex S4; COP9 signalosome complex subunit 4 isoform a; COP9 signalosome complex subunit 4; JAB1-containing signalosome subunit 4; signalosome subunit 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:26891); (R-MMU-5696394); (R-MMU-6781823); (R-MMU-8856825); (R-MMU-8951664); (R-MMU-9013422)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25605945;30084848;34428180;35820727;9707402", "class_list": "", "function": "Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0030054 cell junction;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0000338 protein deneddylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O88544-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P9K9-1", "uniprot_id": [ { "id": "NRX3A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P9K9", "type": "external" } ], "mass": 173428.0, "length": 1571, "protein_name": "Neurexin-3", "gene_name": "Nrxn3", "organism": "Mouse", "refseq_name": "neurexin 3 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001185516", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185516", "type": "external" } ], "gene_names_uniprotkb": "Nrxn3", "gene_names_refseq": "Nrxn3", "protein_names_uniprotkb": "Neurexin-3; Neurexin III-alpha; Neurexin-3-alpha", "protein_names_refseq": "neurexin 3 isoform 1 precursor; neurexin-3-alpha", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:18191); (R-MMU-6794361)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;19926856;21410790;21750661;22220752;24094106;24613359;29782851;30100184;30899004;32434929;33300544;34135511;39090731;8163501;9856994", "class_list": "", "function": "N-terminal sequencing of cow neurexin III beta provides evidence for signal peptide, [RefSeq, PubMed]; N-terminal sequencing of rat neurexin III alpha provides evidence for signal peptide, [RefSeq, PubMed]; Neurexin-3 in the paraventricular nucleus of the hypothalamus regulates body weight and glucose homeostasis independently of food intake. Publication Status: Online-Only, [RefSeq, PubMed]; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. [provided by RefSeq, Dec 2012]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 3, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "E9PW93;E9Q466;Q8CCT8", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding;GO:0005246 calcium channel regulator activity;GO:0097109 neuroligin family protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0097107 postsynaptic density assembly;GO:0097116 gephyrin clustering involved in postsynaptic density assembly;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q6P9K9-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2A0-1", "uniprot_id": [ { "id": "PDPK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2A0", "type": "external" } ], "mass": 63759.0, "length": 559, "protein_name": "3-phosphoinositide-dependent protein kinase 1", "gene_name": "Pdpk1", "organism": "Mouse", "refseq_name": "3-phosphoinositide-dependent protein kinase 1 isoform A", "refseq_ac": [ { "id": "NP_035192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035192", "type": "external" } ], "gene_names_uniprotkb": "Pdpk1; Pdk1", "gene_names_refseq": "Pdk1; Pdpk1", "protein_names_uniprotkb": "3-phosphoinositide-dependent protein kinase 1; 2.7.11.1; mPDK1", "protein_names_refseq": "3-phosphoinositide-dependent protein kinase 1 isoform A; Pkb kinase", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:18607); (R-MMU-114604); (R-MMU-1257604); (R-MMU-165158); (R-MMU-202424); (R-MMU-2730905); (R-MMU-2871837); (R-MMU-354192); (R-MMU-389357); (R-MMU-392451); (R-MMU-5218920); (R-MMU-5218921); (R-MMU-5607764); (R-MMU-5625740); (R-MMU-6804757); (R-MMU-9634635); (R-MMU-9856530)", "pathway_count": 17, "publication_count": 26, "publication_id_list": "10075713;10792047;11877406;11964154;12006370;12054753;14623982;15345747;16150867;16336268;17242355;17371830;17599070;19047061;19429709;19635472;20018868;20584979;21063107;21183079;21750661;23806337;31219806;34428180;38795634;40684658", "class_list": "", "function": "Cloning and characterization of a splice variant of mouse PDK-1, mPDK-1 beta; mPDK-1 beta is highly expressed in the testis and various functional regions of the brain, [RefSeq, PubMed]; Findings suggest the presence of a signaling pathway for insulin-stimulated glucose transport in which PDK1 to PKB or aPKC is not involved, [RefSeq, PubMed]; Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases (PubMed:10075713, PubMed:16150867, PubMed:16336268, PubMed:19047061, PubMed:19635472, PubMed:21063107). Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), TSSK3, protein kinase PKN (PKN1 and PKN2) (PubMed:10075713, PubMed:10792047, PubMed:16336268, PubMed:19047061). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage (By similarity). Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta (By similarity). Activates PPARG transcriptional activity and promotes adipocyte differentiation (PubMed:16150867). Activates the NF-kappa-B pathway via phosphorylation of IKKB (By similarity). The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II (By similarity). Controls proliferation, survival, and growth of developing pancreatic cells (PubMed:19635472). Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells (PubMed:21063107). Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis (PubMed:17371830). Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response (PubMed:19429709). Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses (PubMed:17599070). Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages (PubMed:20584979)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Substitution of the autophosphorylation site Thr516 with a negatively charged residue confers constitutive activity to mouse 3-phosphoinositide-dependent protein kinase-1 in cells, [RefSeq, PubMed]; The contribution of the phosphoinositide-dependent kinase 1 (PDK-1) and activity in controlling the phosphorylation of Thr(566) and Ser(729)of PKC epsilon., [RefSeq, PubMed]; The effect of PDK1 in maintaining immune cell development and function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H6U3;Q9R1D8;Q9R215", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005158 insulin receptor binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0016004 phospholipase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:1905564 positive regulation of vascular endothelial cell proliferation;GO:0006351 DNA-templated transcription;GO:0007165 signal transduction;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q9Z2A0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMB3-1", "uniprot_id": [ { "id": "IF4E2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMB3", "type": "external" } ], "mass": 28263.0, "length": 245, "protein_name": "Eukaryotic translation initiation factor 4E type 2", "gene_name": "Eif4e2", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 4E type 2 isoform 1", "refseq_ac": [ { "id": "NP_001034259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034259", "type": "external" } ], "gene_names_uniprotkb": "Eif4e2; Eif4el3", "gene_names_refseq": "2700069E09Rik; D0H0S6743E; Eif4e2; Eif4el3", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4E type 2; Eukaryotic translation initiation factor 4E-like 3; eIF-4E type 2; eIF4E type 2; eIF4E-2; eIF4E-like protein 4E-LP; mRNA cap-binding protein type 2", "protein_names_refseq": "eIF-4E type 2; eIF4E type 2; eIF4E-2; eIF4E-like protein 4E-LP; eukaryotic translation initiation factor 4E like 3; eukaryotic translation initiation factor 4E type 2 isoform 1; eukaryotic translation initiation factor 4E type 2; mRNA cap-binding protein type 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:26987); (R-MMU-1169408)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15153109;19365557;21750661;22751931;33225984;33581076;34428180;36650535", "class_list": "", "function": "Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. In association with GIGYF2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide. GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data show that Prep1 and 4EHP co-localize in the cytosol of growing mouse oocytes, and that Prep1 binds the Hoxb4 3'UTR to inhibit its translation.[4EHP], [RefSeq, PubMed]; MicroRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP., [RefSeq, PubMed]; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:15153109). Acts as a repressor of translation initiation (By similarity). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (PubMed:15153109). In P-bodies, component of a complex that promotes miRNA-mediated translational repression (By similarity). Involved in virus-induced host response by mediating miRNA MIR34A-induced translational silencing which controls IFNB1 production by a negative feedback mechanism (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88503;Q3UCK2", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0000340 RNA 7-methylguanosine cap binding;GO:0003743 translation initiation factor activity;GO:0098808 mRNA cap binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0000932 P-body;GO:0016281 eukaryotic translation initiation factor 4F complex;GO:0005829 cytosol", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0001701 in utero embryonic development;GO:0060337 type I interferon-mediated signaling pathway;GO:0006413 translational initiation;GO:0017148 negative regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BMB3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C2Q3-1", "uniprot_id": [ { "id": "RBM14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C2Q3", "type": "external" } ], "mass": 69449.0, "length": 669, "protein_name": "RNA-binding protein 14", "gene_name": "Rbm14", "organism": "Mouse", "refseq_name": "RNA-binding protein 14", "refseq_ac": [ { "id": "NP_063922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_063922", "type": "external" } ], "gene_names_uniprotkb": "Rbm14", "gene_names_refseq": "1300007E16Rik; PSP2; Rbm14; Sytip; p16K; p16", "protein_names_uniprotkb": "RNA-binding protein 14; RNA-binding motif protein 14", "protein_names_refseq": "RNA-binding protein 14; synaptotagmin interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:56275); (R-MMU-8941326)", "pathway_count": 2, "publication_count": 34, "publication_id_list": "16452087;17242355;19144319;21183079;21606357;21750661;22517741;22645316;22872234;23806337;25385835;25428506;25605945;29187734;29237092;29729270;30059200;30084848;31219806;31794640;32782141;32848054;34203471;34428180;34678516;34887587;35822049;36477743;36852467;37507081;39627609;40021952;40885482;40997131", "class_list": "", "function": "Maternal mRNA deadenylation and allocation via Rbm14 condensates facilitate vertebrate blastula development., [RefSeq, PubMed]; May function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1 (By similarity). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity (PubMed:25385835). Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway., [UniProtKB, UniProtKB, PubMed]; RBM14 depletion altered the gene expression profiles of mESCs. In particular, pluripotency-associated genes and genes involved in the Wnt and TGF-beta signaling pathways were downregulated in RBM14 knockout mESCs., [RefSeq, PubMed]; Work reveals that Rbm14 plays an essential role in the maintenance of genome integrity during early mouse embryonic development by regulating alternative splicing of DDR-related genes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 14, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 14, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 14, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJB6;Q91Z21;Q9DBI6", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003729 mRNA binding;GO:1990935 splicing factor binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0002218 activation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "Q8C2Q3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97372-1", "uniprot_id": [ { "id": "PSME2_MOUSE", "url": "https://www.uniprot.org/uniprot/P97372", "type": "external" } ], "mass": 27057.0, "length": 239, "protein_name": "Proteasome activator complex subunit 2", "gene_name": "Psme2", "organism": "Mouse", "refseq_name": "proteasome activator complex subunit 2 isoform 2", "refseq_ac": [ { "id": "NP_001025026", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025026", "type": "external" } ], "gene_names_uniprotkb": "Psme2; Pa28b1", "gene_names_refseq": "PA28b; Psme2", "protein_names_uniprotkb": "Proteasome activator complex subunit 2; 11S regulator complex subunit beta; Activator of multicatalytic protease subunit 2; PA28beta; PA28b; Proteasome activator 28 subunit beta; REG-beta", "protein_names_refseq": "11S regulator complex subunit beta; PA28beta; REG-beta; activator of multicatalytic protease subunit 2; protease (prosome, macropain) 28 subunit, beta; proteasome (prosome, macropain) 28 subunit, beta; proteasome activator 28 subunit beta; proteasome activator complex subunit 2 isoform 2; proteasome activator complex subunit 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:19188); (mmu:621823); (R-MMU-1236974); (R-MMU-1236978); (R-MMU-9907900); (R-MMU-9912633)", "pathway_count": 6, "publication_count": 20, "publication_id_list": "11345588;21750661;24788674;25153642;26740625;28135057;28528544;28867616;30400847;31219806;32152506;34203471;34428180;34678516;36210013;37453647;37507081;9162094;9590240;9914329", "class_list": "", "function": "Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Overexpression of PA28alpha and concomitant upregulation of PA28beta protein reduces depressive-like behavior and enhances learning and memory in female mice. The overexpression of PA28alpha does not increase PA28alphabeta-dependent proteasome activity but could still be linked to its protective functions upon oxidative stress and proteinopathy. Publication Status: Online-Only, [RefSeq, PubMed]; Study clarifies the subunit composition and arrangement of PA28ab and provides key insights into the assembly of an asymmetric complex from two highly homologous subunits. Differential scanning fluorimetry experiments and activity assays classify PA28alpha4beta3 as most stable and most active, indicating that this assembly might represent the physiologically relevant species., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35562", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000502 proteasome complex;GO:0008537 proteasome activator complex", "go_biological_process": "GO:2000045 regulation of G1/S transition of mitotic cell cycle;GO:0061136 regulation of proteasomal protein catabolic process;GO:0019884 antigen processing and presentation of exogenous antigen", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P97372-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69Z38-1", "uniprot_id": [ { "id": "PEAK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69Z38", "type": "external" } ], "mass": 191097.0, "length": 1735, "protein_name": "Inactive tyrosine-protein kinase PEAK1", "gene_name": "Peak1", "organism": "Mouse", "refseq_name": "inactive tyrosine-protein kinase PEAK1", "refseq_ac": [ { "id": "NP_766512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766512", "type": "external" } ], "gene_names_uniprotkb": "Peak1; Kiaa2002; Sgk269", "gene_names_refseq": "1110049L02Rik; 9530046P14; C230081A13Rik; Peak1; SGK269; mKIAA2002", "protein_names_uniprotkb": "Inactive tyrosine-protein kinase PEAK1; Pseudopodium-enriched atypical kinase 1; Sugen kinase 269; Tyrosine-protein kinase SgK269", "protein_names_refseq": "NKF3 kinase family member; inactive tyrosine-protein kinase PEAK1; sugen kinase 269; tyrosine-protein kinase SgK269", "tax_id": 10090, "disease": "", "pathway": " (mmu:244895); (R-MMU-9013420); (R-MMU-9013424)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;15592455;18034455;19144319;20534451;21183079;21750661;22645316;25153642;25428506;30084848;31219806;34428180", "class_list": "", "function": "Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics. Acts as a scaffold for mediating EGFR signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "E9QKY2;Q8BX56;Q8R365", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0042802 identical protein binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0016477 cell migration;GO:2000145 regulation of cell motility;GO:0046777 protein autophosphorylation;GO:0034446 substrate adhesion-dependent cell spreading", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q69Z38-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31240-1", "uniprot_id": [ { "id": "PDGFB_MOUSE", "url": "https://www.uniprot.org/uniprot/P31240", "type": "external" } ], "mass": 27382.0, "length": 241, "protein_name": "Platelet-derived growth factor subunit B", "gene_name": "Pdgfb", "organism": "Mouse", "refseq_name": "platelet-derived growth factor subunit B isoform 1 preproprotein", "refseq_ac": [ { "id": "NP_035187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035187", "type": "external" } ], "gene_names_uniprotkb": "Pdgfb; Sis", "gene_names_refseq": "PDGF-2; PDGF-B; Pdgfb; Sis; c-sis", "protein_names_uniprotkb": "Platelet-derived growth factor subunit B; PDGF subunit B; PDGF-2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; Proto-oncogene c-Sis", "protein_names_refseq": "PDGF subunit B; platelet derived growth factor, B polypeptide; platelet-derived growth factor B chain; platelet-derived growth factor beta polypeptide; platelet-derived growth factor subunit B isoform 1 preproprotein; proto-oncogene c-Sis", "tax_id": 10090, "disease": "sinusitis (Disease Ontology:DOID:0050127); inflammatory bowel disease (Disease Ontology:DOID:0050589); basal ganglia calcification (Disease Ontology:DOID:0060230); COVID-19 (Disease Ontology:DOID:0080600); graft-versus-host disease (Disease Ontology:DOID:0081267); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); prostatic hypertrophy (Disease Ontology:DOID:11132); oligohydramnios (Disease Ontology:DOID:12215); leiomyoma (Disease Ontology:DOID:127); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); background diabetic retinopathy (Disease Ontology:DOID:13208); cholestasis (Disease Ontology:DOID:13580); Leydig cell tumor (Disease Ontology:DOID:2696); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); dermatofibrosarcoma protuberans (Disease Ontology:DOID:3507); choriocarcinoma (Disease Ontology:DOID:3594); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); familial meningioma (Disease Ontology:DOID:4586); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (mmu:18591); (R-MMU-114608); (R-MMU-1257604); (R-MMU-186763); (R-MMU-186797); (R-MMU-5673001); (R-MMU-6811558)", "pathway_count": 7, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10734101;11264163;14514732;14561699;15207812;15207813;19030102;2045107;21750661;34428180;37992789;7958863;9211853", "class_list": "", "function": "An integral blood-brain barrier in adulthood relies on microglia-derived PDGFB., [RefSeq, PubMed]; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 28, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P3C4", "ec_number_list": [], "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0005102 signaling receptor binding;GO:0042056 chemoattractant activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0072126 positive regulation of glomerular mesangial cell proliferation;GO:0021782 glial cell development;GO:0072264 metanephric glomerular endothelium development;GO:2000491 positive regulation of hepatic stellate cell activation;GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P31240-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHF7-1", "uniprot_id": [ { "id": "PGPS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHF7", "type": "external" } ], "mass": 62489.0, "length": 553, "protein_name": "CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial", "gene_name": "Pgs1", "organism": "Mouse", "refseq_name": "CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial", "refseq_ac": [ { "id": "NP_598518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598518", "type": "external" } ], "gene_names_uniprotkb": "Pgs1; Saf", "gene_names_refseq": "2610019F11Rik; 4933424M23Rik; Pgs1; SAF", "protein_names_uniprotkb": "CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial; 2.7.8.5; PGP synthase 1; Phosphatidylglycerophosphate synthase 1; Silencer-associated factor", "protein_names_refseq": "CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial; PGP synthase 1; silencer-associated factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:74451)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;34428180;9880566", "class_list": "", "function": "Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8QZT9;Q8R4R7", "ec_number_list": [ { "id": "2.7.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.5", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016788 hydrolase activity, acting on ester bonds;GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0008654 phospholipid biosynthetic process;GO:0006655 phosphatidylglycerol biosynthetic process;GO:0032049 cardiolipin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BHF7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UBG2-1", "uniprot_id": [ { "id": "PCLI1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UBG2", "type": "external" } ], "mass": 24784.0, "length": 217, "protein_name": "PTB-containing, cubilin and LRP1-interacting protein", "gene_name": "Pid1", "organism": "Mouse", "refseq_name": "PTB-containing, cubilin and LRP1-interacting protein", "refseq_ac": [ { "id": "NP_001003948", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003948", "type": "external" } ], "gene_names_uniprotkb": "Pid1; Pcli1", "gene_names_refseq": "5033414K04Rik; NYGGF4; P-CLI1; Pid1", "protein_names_uniprotkb": "PTB-containing, cubilin and LRP1-interacting protein; P-CLI1; Phosphotyrosine interaction domain-containing protein 1", "protein_names_refseq": "PTB-containing, cubilin and LRP1-interacting protein; phosphotyrosine interaction domain-containing protein 1", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (mmu:98496)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17242355;19144319;19894142;21750661;23443082;29391195;30100244;30904610;34428180", "class_list": "", "function": "By acting as an insulin-dependent retention adaptor, PID1 serves as a regulator of LRP1 function controlling the disposal of postprandial lipoproteins., [RefSeq, PubMed]; Data demonstrate that differentially methylated genes are significantly overrepresented in NYGGF4-overexpression adipocytes, providing valuable clues for further exploration of the role of NYGGF4 in insulin sensitivity regulation. Publication Status: Online-Only, [RefSeq, PubMed]; Increases proliferation of preadipocytes without affecting adipocytic differentiation., [UniProtKB]; Results thus indicate phosphotyrosine interaction domain containing 1 (PID1) as a critical regulator of glucose metabolism in adipocytes., [RefSeq, PubMed]; The data provide evidence that PID1 serves as an insulin-regulated retention adaptor protein controlling translocation of LRP1 in conjunction with GLUT4 to the plasma membrane of adipocytes., [RefSeq, PubMed]; The expression of NYGGF4 mRNA is affected by a variety of factors that are related to insulin sensitivity.[NYGGF4], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UAR0;Q68EE9;Q7TPS1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:2001171 positive regulation of ATP biosynthetic process;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051881 regulation of mitochondrial membrane potential", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3UBG2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6W8Q3-1", "uniprot_id": [ { "id": "PC4L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6W8Q3", "type": "external" } ], "mass": 7502.0, "length": 68, "protein_name": "Purkinje cell protein 4-like protein 1", "gene_name": "Pcp4l1", "organism": "Mouse", "refseq_name": "Purkinje cell protein 4-like protein 1", "refseq_ac": [ { "id": "NP_079833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079833", "type": "external" } ], "gene_names_uniprotkb": "Pcp4l1", "gene_names_refseq": "1500036F01Rik; Pcp4l1", "protein_names_uniprotkb": "Purkinje cell protein 4-like protein 1; PCP4-like protein 1", "protein_names_refseq": "PCP4-like protein 1; Purkinje cell protein 4-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66425)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15053978;17242355;21183079;22458599", "class_list": "", "function": "Pcp4l1 encodes a polypeptide with significant sequence similarity to the Purkinje cell protein 4 gene (Pcp40;it is expressed during mouse development., [RefSeq, PubMed]; We speculate Pcp4l1 may be a latent calmodulin inhibitor regulated by post-translational modification and/or co-factor interactions, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CW92", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6W8Q3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BFP9-1", "uniprot_id": [ { "id": "PDK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BFP9", "type": "external" } ], "mass": 48995.0, "length": 434, "protein_name": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial", "gene_name": "Pdk1", "organism": "Mouse", "refseq_name": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_766253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766253", "type": "external" } ], "gene_names_uniprotkb": "Pdk1", "gene_names_refseq": "B830012B01; D530020C15Rik; Pdk1", "protein_names_uniprotkb": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial; 2.7.11.2; PDH kinase 1; Pyruvate dehydrogenase kinase isoform 1", "protein_names_refseq": "PDH kinase 1; [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial isoform 1 precursor; [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial; pyruvate dehydrogenase kinase, isozyme 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:228026); (R-MMU-204174); (R-MMU-5362517); (R-MMU-9837999)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "16517406;16631612;20160671;22195962;23806337;34418053;34428180", "class_list": "", "function": "Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia (By similarity)., [UniProtKB, PubMed, UniProtKB]; Pdk1 enzyme is critical in conserving mitochondrial function by diverting metabolic intermediates to glycolysis, [RefSeq, PubMed]; The tyrosine phosphorylation enhances PDHK1 kinase activity by promoting ATP and PDC binding., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5E5", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "2.3.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.12", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005886 plasma membrane;GO:0045254 pyruvate dehydrogenase complex", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007166 cell surface receptor signaling pathway;GO:0008283 cell population proliferation;GO:0035556 intracellular signal transduction;GO:0010906 regulation of glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BFP9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZF8-1", "uniprot_id": [ { "id": "PGM5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZF8", "type": "external" } ], "mass": 62220.0, "length": 567, "protein_name": "Phosphoglucomutase-like protein 5", "gene_name": "Pgm5", "organism": "Mouse", "refseq_name": "phosphoglucomutase-like protein 5", "refseq_ac": [ { "id": "NP_778178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778178", "type": "external" } ], "gene_names_uniprotkb": "Pgm5; Aciculin", "gene_names_refseq": "4833423B07; 9530034F03Rik; D830025G17; Pgm5; aciculin", "protein_names_uniprotkb": "Phosphoglucomutase-like protein 5", "protein_names_refseq": "phosphoglucomutase-like protein 5", "tax_id": 10090, "disease": "congenital disorder of glycosylation It (Disease Ontology:DOID:0080570)", "pathway": " (mmu:226041)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17242355;21183079;24963132;34428180;37507081;7890770", "class_list": "glycogene", "function": "Aciculin interacts with filamin C and Xin and is essential for myofibril assembly., [RefSeq, PubMed]; Component of adherens-type cell-cell and cell-matrix junctions (By similarity). Positively regulates maturation and alignment of myofibrils, also promotes organization of sarcomeres (PubMed:24963132). Has no phosphoglucomutase activity in vitro (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0016868 intramolecular phosphotransferase activity", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0005829 cytosol;GO:0005912 adherens junction;GO:0005925 focal adhesion;GO:0014704 intercalated disc", "go_biological_process": "GO:0014706 striated muscle tissue development;GO:0007155 cell adhesion;GO:0005975 carbohydrate metabolic process;GO:0030239 myofibril assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BZF8-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYX7-1", "uniprot_id": [ { "id": "PCLO_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYX7", "type": "external" } ], "mass": 550834.0, "length": 5068, "protein_name": "Protein piccolo", "gene_name": "Pclo", "organism": "Mouse", "refseq_name": "protein piccolo isoform 2", "refseq_ac": [ { "id": "NP_001104266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104266", "type": "external" } ], "gene_names_uniprotkb": "Pclo; Acz", "gene_names_refseq": "Acz; Pclo; Pico", "protein_names_uniprotkb": "Protein piccolo; Aczonin; Brain-derived HLMN protein; Multidomain presynaptic cytomatrix protein", "protein_names_refseq": "aczonin; brain-derived HLMN protein; multidomain presynaptic cytomatrix protein; protein piccolo isoform 2; protein piccolo", "tax_id": 10090, "disease": "pontocerebellar hypoplasia type 3 (Disease Ontology:DOID:0060272); melancholic depression (Disease Ontology:DOID:1595)", "pathway": " (mmu:26875)", "pathway_count": 1, "publication_count": 34, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;10508862;12401793;16452087;16452088;17114649;18034455;19458039;19812333;20173027;21158410;21183079;21750661;22517741;22645316;22826440;25428506;26192747;28231469;30084848;31599954;32848054;33300544;33601422;33882456;34678516;35820727;35822049;36757814;38552623;39627609;40021952;40885482", "class_list": "", "function": "ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease., [RefSeq, PubMed]; Binds to cAMP-GEFII and forms both homodimer and heterodimer with Rim2 in a Ca(2+)-dependent manner, whereas Rim2 alone does not form the homodimer, [RefSeq, PubMed]; Piccolo is essential for the maintenance of mouse retina but not cochlear hair cell function., [RefSeq, PubMed]; Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:19812333). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy (By similarity) (PubMed:28231469). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 15, "predicted_n_glycosites": 0, "predicted_o_glycosites": 15, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 3, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 188, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 188, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 188, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 66, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 9, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 204, "binding_glycan_count": 0, "secondary_ac_list": "E9QK94;Q8CF91;Q8CF92;Q9QYX6;Q9QZJ0", "ec_number_list": [], "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0005522 profilin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0005798 Golgi-associated vesicle;GO:0014069 postsynaptic density", "go_biological_process": "GO:0016080 synaptic vesicle targeting;GO:0097091 synaptic vesicle clustering;GO:0050808 synapse organization;GO:0098815 modulation of excitatory postsynaptic potential;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 22.6, "record_id": "Q9QYX7-1", "record_type": "protein", "filter_code": "0000000.1000111.000100.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99K01-1", "uniprot_id": [ { "id": "PDXD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99K01", "type": "external" } ], "mass": 87335.0, "length": 787, "protein_name": "Pyridoxal-dependent decarboxylase domain-containing protein 1", "gene_name": "Pdxdc1", "organism": "Mouse", "refseq_name": "pyridoxal-dependent decarboxylase domain-containing protein 1 isoform 3", "refseq_ac": [ { "id": "NP_001034622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034622", "type": "external" } ], "gene_names_uniprotkb": "Pdxdc1", "gene_names_refseq": "2210010A19Rik; Kiaa0251-hp; Pdxdc1", "protein_names_uniprotkb": "Pyridoxal-dependent decarboxylase domain-containing protein 1; 4.1.1.-", "protein_names_refseq": "pyridoxal-dependent decarboxylase domain-containing protein 1 isoform 3; pyridoxal-dependent decarboxylase domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:94184)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19131326;21183079;21750661;28528544;34428180;35314877;37828378", "class_list": "", "function": "Identification of PDXDC1 as a novel pleiotropic susceptibility locus shared between lumbar spine bone mineral density and birth weight., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCL3;Q3TN13;Q8BMK9;Q8BW02;Q8BW51;Q8BZZ4;Q9DC25", "ec_number_list": [], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0016831 carboxy-lyase activity;GO:0016830 carbon-carbon lyase activity", "go_cellular_component": "GO:0005794 Golgi apparatus", "go_biological_process": "GO:0019752 carboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q99K01-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIG1-1", "uniprot_id": [ { "id": "REST_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VIG1", "type": "external" } ], "mass": 117784.0, "length": 1082, "protein_name": "RE1-silencing transcription factor", "gene_name": "Rest", "organism": "Mouse", "refseq_name": "RE1-silencing transcription factor", "refseq_ac": [ { "id": "NP_035393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035393", "type": "external" } ], "gene_names_uniprotkb": "Rest; Nrsf", "gene_names_refseq": "2610008J04Rik; NRSF; REST4; Rest", "protein_names_uniprotkb": "RE1-silencing transcription factor; Neural-restrictive silencer factor", "protein_names_refseq": "RE1-silencing transcription factor; neural-restrictive silencer factor", "tax_id": 10090, "disease": "gingival fibromatosis 5 (Disease Ontology:DOID:0080280); autosomal dominant nonsyndromic deafness 27 (Disease Ontology:DOID:0110556); alcohol use disorder (Disease Ontology:DOID:1574); nephroblastoma (Disease Ontology:DOID:2154)", "pathway": " (mmu:19712); (R-MMU-3214815)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10490617;10521596;11039732;15907476;21284946;21884984;24523346;24670762;25727884;27819263;29961578;34418053;34428180;38606882;7697725;7871435;9771705", "class_list": "", "function": "Binds to the 3' region of the neuron-restrictive silencer element (NRSE), with lower affinity than isoform 1 (PubMed:11039732). Exhibits weaker repressor activity compared to isoform 1 (By similarity). May negatively regulate the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes (PubMed:10490617, PubMed:11039732). However, in another study, does not appear to be implicated in repressor activity of a NRSE motif-containing reporter construct nor in inhibitory activity on the isoform 1 transcriptional repressor activity (By similarity). Post-transcriptional inactivation of REST by SRRM4-dependent alternative splicing into isoform 2 is required in mechanosensory hair cells in the inner ear for derepression of neuronal genes, maintenance of hair cells and hearing (PubMed:29961578)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; The homeostatic effects of the RE-1 silencing transcription factor on cortical networks are altered under ictogenic conditions in the mouse., [RefSeq, PubMed]; Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (PubMed:29961578, PubMed:9771705). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (By similarity). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (By similarity). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (By similarity). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 2 (PubMed:21884984). Repressor activity may be inhibited by forming heterodimers with isoform 2, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (PubMed:10490617, PubMed:11039732). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (PubMed:15907476). Thereby is involved in maintaining the quiescent state of adult neural stem cells and preventing premature differentiation into mature neurons (PubMed:27819263). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (By similarity). Acts as a regulator of osteoblast differentiation (PubMed:25727884). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (By similarity). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (PubMed:24670762). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (By similarity). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A0JNY8;Q155C6;Q3U0W0;Q4VAD6;Q9CW43", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0017053 transcription repressor complex", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:0060379 cardiac muscle cell myoblast differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0002931 response to ischemia;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8VIG1-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18828-1", "uniprot_id": [ { "id": "SDC1_MOUSE", "url": "https://www.uniprot.org/uniprot/P18828", "type": "external" } ], "mass": 32905.0, "length": 311, "protein_name": "Syndecan-1", "gene_name": "Sdc1", "organism": "Mouse", "refseq_name": "syndecan-1 precursor", "refseq_ac": [ { "id": "NP_035649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035649", "type": "external" } ], "gene_names_uniprotkb": "Sdc1; Synd-1; Synd1", "gene_names_refseq": "CD138; Sdc1; Sstn; Synd1; Synd; syn-1", "protein_names_uniprotkb": "Syndecan-1; SYND1", "protein_names_refseq": "syndecan-1 precursor; synstatin", "tax_id": 10090, "disease": "familial hyperlipidemia (Disease Ontology:DOID:1168); lung adenocarcinoma (Disease Ontology:DOID:3910); hyperglycemia (Disease Ontology:DOID:4195); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); Hodgkin's lymphoma (Disease Ontology:DOID:8567); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:20969); (R-MMU-1971475); (R-MMU-2022928); (R-MMU-2024096); (R-MMU-3000170); (R-MMU-449836); (R-MMU-975634); (R-MMU-9769735); (R-MMU-9769739)", "pathway_count": 9, "publication_count": 15, "publication_id_list": "10373479;10684261;16156648;20361982;21750661;2494194;33725478;35820727;38451352;39273320;39950214;8163535;8349612;8496192;8898217", "class_list": "glycogene", "function": "Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (PubMed:8163535). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (By similarity). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (PubMed:8898217)., [UniProtKB, UniProtKB, PubMed, PubMed]; Lack of Syndecan-1 promotes the pathogenesis of experimental rheumatoid arthritis., [RefSeq, PubMed]; Syndecan-1 Plays a Role in the Pathogenesis of Sjogren's Disease by Inducing B-Cell Chemotaxis through CXCL13-Heparan Sulfate Interaction. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 5, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q62278;Q9WVD2", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005796 Golgi lumen;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0016477 cell migration;GO:0006898 receptor-mediated endocytosis;GO:0060070 canonical Wnt signaling pathway;GO:1903543 positive regulation of exosomal secretion;GO:1903553 positive regulation of extracellular exosome assembly", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P18828-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000010001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61473-1", "uniprot_id": [ { "id": "SOX17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61473", "type": "external" } ], "mass": 44646.0, "length": 419, "protein_name": "Transcription factor SOX-17", "gene_name": "Sox17", "organism": "Mouse", "refseq_name": "transcription factor SOX-17 isoform a", "refseq_ac": [ { "id": "NP_001276393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276393", "type": "external" } ], "gene_names_uniprotkb": "Sox17; Sox-17", "gene_names_refseq": "Sox17", "protein_names_uniprotkb": "Transcription factor SOX-17", "protein_names_refseq": "SRY-box containing gene 17; transcription factor SOX-17 isoform a; transcription factor SOX-17", "tax_id": 10090, "disease": "intracranial aneurysm (Disease Ontology:DOID:10941); biliary atresia (Disease Ontology:DOID:13608); patent ductus arteriosus (Disease Ontology:DOID:13832); primary pulmonary hypertension (Disease Ontology:DOID:14557); cholangiocarcinoma (Disease Ontology:DOID:4947); pulmonary hypertension (Disease Ontology:DOID:6432); vesicoureteral reflux (Disease Ontology:DOID:9620)", "pathway": " (mmu:20671); (R-MMU-3769402)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11973269;16895970;17655922;19328208;20802155;21750661;24153254;35820727;8636240", "class_list": "glycogene", "function": "Acts as a transcription regulator that binds target promoter DNA and bends the DNA (PubMed:19328208, PubMed:24153254, PubMed:8636240). Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3' (PubMed:8636240). Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development (PubMed:11973269, PubMed:17655922, PubMed:24153254). Required for normal development of the definitive gut endoderm (PubMed:11973269). Required for normal looping of the embryonic heart tube. Plays an important role in embryonic and postnatal vascular development, including development of arteries (PubMed:24153254). Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX18 (PubMed:16895970). Required for the generation and maintenance of fetal hematopoietic stem cells, and for fetal hematopoiesis (PubMed:17655922). Probable transcriptional activator in the premeiotic germ cells., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Has no DNA-binding activity, and does not function as transcriptional activator., [UniProtKB, PubMed]; Important role of Sox17 in endoderm development in the mouse, [RefSeq, PubMed]; This gene encodes a member of the Sox (Sry-related high mobility group box) family of transcription factors involved in the regulation of embryonic development. The encoded protein plays a role in the determination of cell fate and in maintaining cell identity. This gene regulates tumor angiogenesis and tumor progression. Mutations in the human gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q61472;Q62248", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0043279 response to alkaloid;GO:0061010 gallbladder development;GO:0060214 endocardium formation;GO:0001714 endodermal cell fate specification;GO:0061031 endodermal digestive tract morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q61473-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K0C8-1", "uniprot_id": [ { "id": "COX19_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K0C8", "type": "external" } ], "mass": 10821.0, "length": 92, "protein_name": "Cytochrome c oxidase assembly protein COX19", "gene_name": "Cox19", "organism": "Mouse", "refseq_name": "cytochrome c oxidase assembly protein COX19", "refseq_ac": [ { "id": "NP_932097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932097", "type": "external" } ], "gene_names_uniprotkb": "Cox19", "gene_names_refseq": "1810074D02Rik; 2810437L13Rik; Cox19", "protein_names_uniprotkb": "Cytochrome c oxidase assembly protein COX19", "protein_names_refseq": "COX19 cytochrome c oxidase assembly homolog; cytochrome c oxidase assembly protein COX19", "tax_id": 10090, "disease": "", "pathway": " (mmu:68033); (R-MMU-9864848)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;23676665", "class_list": "", "function": "Assembly factor for cytochrome c oxidase (respiratory chain complex IV, CIV). Acts as a COX11 chaperone that supports COX11 copper coordination. Also stimulates SCO2-mediated metalation of COX2. Required for the transduction of an SCO1-dependent redox signal from the mitochondrion to ATP7A to regulate cellular copper homeostasis. In the absence of COX11, capable of stimulating copper delivery to the copper B site of COX1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0006878 intracellular copper ion homeostasis;GO:0051604 protein maturation;GO:0033617 mitochondrial respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K0C8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CB96-1", "uniprot_id": [ { "id": "RASF4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CB96", "type": "external" } ], "mass": 36934.0, "length": 322, "protein_name": "Ras association domain-containing protein 4", "gene_name": "Rassf4", "organism": "Mouse", "refseq_name": "ras association domain-containing protein 4", "refseq_ac": [ { "id": "NP_835146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_835146", "type": "external" } ], "gene_names_uniprotkb": "Rassf4", "gene_names_refseq": "3830411C14Rik; AD037; Rassf4", "protein_names_uniprotkb": "Ras association domain-containing protein 4", "protein_names_refseq": "Ras association (RalGDS/AF-6) domain family 4; ras association domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:213391)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBK1;Q3TPH9;Q3TUT0;Q6P9L7;Q8CIM6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CB96-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2Q3-1", "uniprot_id": [ { "id": "PAAT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2Q3", "type": "external" } ], "mass": 48743.0, "length": 444, "protein_name": "ATPase PAAT", "gene_name": "2310057M21Rik; Paat", "organism": "Mouse", "refseq_name": "ATPase PAAT", "refseq_ac": [ { "id": "NP_080931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080931", "type": "external" } ], "gene_names_uniprotkb": "2310057M21Rik; Paat", "gene_names_refseq": "2310057M21Rik; 3110040E10Rik; PAAT", "protein_names_uniprotkb": "ATPase PAAT; 3.6.1.-; PAAT; Protein associated with ABC transporters", "protein_names_refseq": "ATPase PAAT; protein associated with ABC transporters; uncharacterized protein C10orf88 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68277)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;31219806", "class_list": "", "function": "ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10. Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D2Q3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17564-1", "uniprot_id": [ { "id": "PR15A_MOUSE", "url": "https://www.uniprot.org/uniprot/P17564", "type": "external" } ], "mass": 71840.0, "length": 657, "protein_name": "Protein phosphatase 1 regulatory subunit 15A", "gene_name": "Ppp1r15a", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 15A", "refseq_ac": [ { "id": "NP_032680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032680", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r15a; Gadd34; Myd116", "gene_names_refseq": "9630030H21; Gadd34; Myd116; Ppp1r15a", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 15A; Growth arrest and DNA damage-inducible protein GADD34; Myeloid differentiation primary response protein MyD116", "protein_names_refseq": "growth arrest and DNA damage-inducible protein GADD34; growth arrest and DNA-damage-inducible 34; myeloid differentiation primary response gene 116; myeloid differentiation primary response protein MyD116; protein phosphatase 1 regulatory subunit 15A; protein phosphatase 1, regulatory (inhibitor) subunit 15A", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); thalassemia (Disease Ontology:DOID:10241); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (mmu:17872)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11381086;11517336;12606582;12824288;16478986;17670836;19131336;21750661;2339071;31219806;38842564;8139541;9023344;9371605", "class_list": "", "function": "GADD34 translation is regulated by a unique 5'UTR uORF mechanism to ensure proper GADD34 expression during eIF2alpha phosphorylation, [RefSeq, PubMed]; Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress (PubMed:11381086, PubMed:12824288). Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1 (By similarity). May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15' (By similarity). Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux (By similarity). Also acts a viral restriction factor by attenuating vesicular stomatitis virus (VSV) replication (PubMed:17670836)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Silencing of the DNA damage repair regulator PPP1R15A sensitizes acute myeloid leukemia cells to chemotherapy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJS6;Q3U3L5;Q8C579", "ec_number_list": [], "go_molecular_function": "GO:0071074 eukaryotic initiation factor eIF2 binding;GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0019888 protein phosphatase regulator activity;GO:0008157 protein phosphatase 1 binding", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0032058 positive regulation of translational initiation in response to stress;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001934 positive regulation of protein phosphorylation;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P17564-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54822-1", "uniprot_id": [ { "id": "PUR8_MOUSE", "url": "https://www.uniprot.org/uniprot/P54822", "type": "external" } ], "mass": 54866.0, "length": 484, "protein_name": "Adenylosuccinate lyase", "gene_name": "Adsl", "organism": "Mouse", "refseq_name": "adenylosuccinate lyase", "refseq_ac": [ { "id": "NP_033764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033764", "type": "external" } ], "gene_names_uniprotkb": "Adsl; Adl", "gene_names_refseq": "Adl; Adsl; Asl", "protein_names_uniprotkb": "Adenylosuccinate lyase; 4.3.2.2; ASL; ASase; Adenylosuccinase", "protein_names_refseq": "ASase; adenylosuccinase; adenylosuccinate lyase 1; adenylosuccinate lyase", "tax_id": 10090, "disease": "adenylosuccinase lyase deficiency (Disease Ontology:DOID:0050762); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (mmu:11564); (R-MMU-73817)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;31219806;34428180;37507081;39927985;8530047", "class_list": "", "function": "Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a protein that is involved in adenosine monophosphate (AMP) biosynthesis and maintaining AMP levels in the muscle. The encoded enzyme catalyzes the release of fumarate during AMP biosynthesis by cleaving the substrates succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide (AICA) ribotide, and adenylosuccinate to give adenylate. In humans, this gene is associated with adenylosuccinate deficiency, a rare autosomal disorder resulting in a spectrum of neurological symptoms. A pseudogene associated with this gene is located on the X chromosome. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCD4", "ec_number_list": [ { "id": "4.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.2", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity;GO:0070626 (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity;GO:0016829 lyase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007584 response to nutrient;GO:0042594 response to starvation;GO:0001666 response to hypoxia;GO:0044209 AMP salvage;GO:0014850 response to muscle activity", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P54822-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6WBX7-1", "uniprot_id": [ { "id": "RAD9B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6WBX7", "type": "external" } ], "mass": 44840.0, "length": 403, "protein_name": "Cell cycle checkpoint control protein RAD9B", "gene_name": "Rad9b", "organism": "Mouse", "refseq_name": "cell cycle checkpoint control protein RAD9B isoform 1", "refseq_ac": [ { "id": "NP_659161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659161", "type": "external" } ], "gene_names_uniprotkb": "Rad9b", "gene_names_refseq": "A630082N15Rik; Rad9b", "protein_names_uniprotkb": "Cell cycle checkpoint control protein RAD9B; DNA repair exonuclease rad9 homolog B; mRAD9B", "protein_names_refseq": "DNA repair exonuclease rad9 homolog B; RAD9 homolog B; cell cycle checkpoint control protein RAD9B homolog; cell cycle checkpoint control protein RAD9B isoform 1; mRAD9B", "tax_id": 10090, "disease": "", "pathway": " (mmu:231724); (R-MMU-176187); (R-MMU-5685938); (R-MMU-5693607); (R-MMU-6804756); (R-MMU-69473)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "14500360;20842695;21183079;21750661;33300544", "class_list": "", "function": "Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity., [UniProtKB, UniProtKB]; Fndings thus indicate that Mrad9b is essential for embryonic development and mediates resistance to certain DNA damaging agents., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0030896 checkpoint clamp complex", "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0006281 DNA repair;GO:0071479 cellular response to ionizing radiation;GO:0031573 mitotic intra-S DNA damage checkpoint signaling;GO:0000077 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6WBX7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z160-1", "uniprot_id": [ { "id": "COG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z160", "type": "external" } ], "mass": 109050.0, "length": 980, "protein_name": "Conserved oligomeric Golgi complex subunit 1", "gene_name": "Cog1", "organism": "Mouse", "refseq_name": "conserved oligomeric Golgi complex subunit 1", "refseq_ac": [ { "id": "NP_038609", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038609", "type": "external" } ], "gene_names_uniprotkb": "Cog1; Ldlb", "gene_names_refseq": "6030445I15; Cog1; Ldlb; mKIAA1381", "protein_names_uniprotkb": "Conserved oligomeric Golgi complex subunit 1; COG complex subunit 1; Component of oligomeric Golgi complex 1; Low density lipoprotein receptor defect B-complementing protein", "protein_names_refseq": "COG complex subunit 1; conserved oligomeric Golgi complex subunit 1; low density lipoprotein B; low density lipoprotein receptor defect B-complementing protein", "tax_id": 10090, "disease": "congenital disorder of glycosylation type IIg (Disease Ontology:DOID:0070259)", "pathway": " (mmu:16834); (R-MMU-6807878); (R-MMU-6811438); (R-MMU-6811440)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "21750661;23806337;25428506;28528544;30084848;34428180;9927668", "class_list": "", "function": "Required for normal Golgi function., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P567", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0017119 Golgi transport complex", "go_biological_process": "GO:0015031 protein transport;GO:0007030 Golgi organization;GO:0000301 retrograde transport, vesicle recycling within Golgi;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9Z160-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NZJ6-1", "uniprot_id": [ { "id": "IF4G1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NZJ6", "type": "external" } ], "mass": 176077.0, "length": 1600, "protein_name": "Eukaryotic translation initiation factor 4 gamma 1", "gene_name": "Eif4g1", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 4 gamma 1 isoform c", "refseq_ac": [ { "id": "NP_001291361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291361", "type": "external" } ], "gene_names_uniprotkb": "Eif4g1", "gene_names_refseq": "E030015G23Rik; Eif4g1; eIF-4-gamma 1; eIF-4G 1; eIF-4G1; eIF4GI", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4 gamma 1; eIF-4-gamma 1; eIF-4G 1; eIF-4G1", "protein_names_refseq": "eukaryotic translation initiation factor 4 gamma 1 isoform c", "tax_id": 10090, "disease": "late onset Parkinson's disease (Disease Ontology:DOID:0060892); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:208643); (R-MMU-1169408); (R-MMU-156827); (R-MMU-166208); (R-MMU-429947); (R-MMU-450408); (R-MMU-72649); (R-MMU-72662); (R-MMU-72702); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957)", "pathway_count": 12, "publication_count": 36, "publication_id_list": "10.1101/2023.09.13.557529;15153109;15234964;17242355;18630941;19131326;19144319;21183079;21750661;23806337;24129315;24928504;25153642;25428506;25605945;26495903;28528544;29237092;30059200;30084848;30127386;30779550;31219806;31300553;31599954;32782141;34428180;34887587;35820727;36288343;37307456;37453647;37828378;39627609;39927985;40885482", "class_list": "", "function": "Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon. Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation., [UniProtKB, UniProtKB]; EIF4G binding to Mnk is inhibted by Mnk1 phosphorylation by caspase-activated Pak2/gamma-PAK, [RefSeq, PubMed]; The mRNA translation initiation factor eIF4G1 controls mitochondrial oxidative phosphorylation, axonal morphogenesis, and memory., [RefSeq, PubMed]; This gene encodes a member of the eukaryotic translation initiation factors (eIF) that play important roles in translation initiation by mediating recruitment of additional initiation factors and providing a scaffold for ribosome/mRNA-bridging. Along with eIF4A and eIF4E, the encoded protein forms the eIF4F complex that bridges the 5' UTR with the polyadenylated 3' UTR resulting in mRNA circularization, enhanced translation initiation and mRNA stability. Through its association with eIF3, the encoded protein mediates recruitment of the 43S pre-initiation complex to mRNA. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes for this gene have been identified on chromosomes 2 and 13. [provided by RefSeq, Jan 2015]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q6NZN8;Q8BW99", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0008190 eukaryotic initiation factor 4E binding;GO:0008135 translation factor activity, RNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0098794 postsynapse;GO:0016281 eukaryotic translation initiation factor 4F complex", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0045666 positive regulation of neuron differentiation;GO:0051247 positive regulation of protein metabolic process;GO:0097009 energy homeostasis;GO:0006413 translational initiation", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "Q6NZJ6-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100010001001.011.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZPI0-1", "uniprot_id": [ { "id": "JADE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZPI0", "type": "external" } ], "mass": 93897.0, "length": 834, "protein_name": "Protein Jade-1", "gene_name": "Jade1", "organism": "Mouse", "refseq_name": "protein Jade-1", "refseq_ac": [ { "id": "NP_001123656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123656", "type": "external" } ], "gene_names_uniprotkb": "Jade1; Kiaa1807; Phf17", "gene_names_refseq": "D530048A03Rik; Jade1; Phf17; mKIAA1807", "protein_names_uniprotkb": "Protein Jade-1; Jade family PHD finger protein 1; PHD finger protein 17", "protein_names_refseq": "Jade1 PHD finger protein; PHD finger protein 17; jade family PHD finger protein 1; protein Jade-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:269424); (R-MMU-3214847)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12169691;14612400;21750661;23806337;25428506;26919559;31219806;34428180;38171233", "class_list": "", "function": "Exhibits a regulated expression during embryogenesis and localizes to the nucleus and/or cytoplasm of different cell types, [RefSeq, PubMed]; Interactome analyses revealed that the Jade-1S mutant unable to be phosphorylated by CK1alpha has an increased binding affinity to proteins involved in chromatin remodelling, histone deacetylation, transcriptional repression, and ribosome biogenesis., [RefSeq, PubMed]; JADE1 is dispensable for the brain development in mice., [RefSeq, PubMed]; Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation. May also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9073, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6IE84;Q8C7S6;Q8CFM2;Q8R362", "ec_number_list": [], "go_molecular_function": "GO:0043997 histone H4K12 acetyltransferase activity;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0043995 histone H4K5 acetyltransferase activity;GO:0043996 histone H4K8 acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:2000278 regulation of DNA biosynthetic process;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0090090 negative regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6ZPI0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFN5-1", "uniprot_id": [ { "id": "MEF2C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CFN5", "type": "external" } ], "mass": 51278.0, "length": 474, "protein_name": "Myocyte-specific enhancer factor 2C", "gene_name": "Mef2c", "organism": "Mouse", "refseq_name": "myocyte-specific enhancer factor 2C isoform 3", "refseq_ac": [ { "id": "NP_001334493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334493", "type": "external" } ], "gene_names_uniprotkb": "Mef2c", "gene_names_refseq": "5430401D19Rik; 9930028G15Rik; Mef2c; Mef2", "protein_names_uniprotkb": "Myocyte-specific enhancer factor 2C; Myocyte enhancer factor 2C", "protein_names_refseq": "myocyte-specific enhancer factor 2C isoform 3; myocyte-specific enhancer factor 2C", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language (Disease Ontology:DOID:0070050); intellectual disability (Disease Ontology:DOID:1059); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); status epilepticus (Disease Ontology:DOID:1824); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:17260); (R-MMU-525793)", "pathway_count": 2, "publication_count": 32, "publication_id_list": "10.3389/fragi.2021.757801;11279209;11554755;11713257;15340086;15834131;16818234;18086704;18438409;18599437;18599438;19211936;19753306;20139090;20801874;21183079;21750661;22956541;25789873;26160456;26788505;32736694;32848054;32851972;33941892;35822049;40885482;8506376;8663403;9013788;9162005;9778514", "class_list": "", "function": "Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development (PubMed:33941892). Enhances transcriptional activation mediated by SOX18 (PubMed:11554755). May also be involved in neurogenesis and in the development of cortical architecture. Isoforms that lack the repressor domain are more active than isoform 1 (By similarity). Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0H1;Q9D7L0;Q9QW20", "ec_number_list": [], "go_molecular_function": "GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0098989 NMDA selective glutamate receptor signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0002931 response to ischemia;GO:0006351 DNA-templated transcription;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "Q8CFN5-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AL36-1", "uniprot_id": [ { "id": "CNTRL_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AL36", "type": "external" } ], "mass": 268880.0, "length": 2334, "protein_name": "Centriolin", "gene_name": "Cntrl", "organism": "Mouse", "refseq_name": "centriolin isoform 4", "refseq_ac": [ { "id": "NP_001366203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001366203", "type": "external" } ], "gene_names_uniprotkb": "Cntrl; Cep110; Cep1", "gene_names_refseq": "6720467O09Rik; Cep110; Cep1; Cntrl; IB3/5; Ma2a8; b2b1468.1Clo; b2b1468Clo", "protein_names_uniprotkb": "Centriolin; Centrosomal protein 1; Centrosomal protein of 110 kDa; Cep110", "protein_names_refseq": "110 kDa centrosomal protein; antigen identified by monoclonal antibody 2A8; centriolin isoform 4; centrosomal protein 110; centrosomal protein of 110 kDa", "tax_id": 10090, "disease": "nephronophthisis (Disease Ontology:DOID:12712)", "pathway": "", "pathway_count": 0, "publication_count": 8, "publication_id_list": "10688839;21183079;21750661;23777766;28075662;31219806;34428180;40021952", "class_list": "", "function": "CNTRL and FGFR1 have roles in myeloid and lymphoid malignancies in both human and mouse models, [RefSeq, PubMed]; Centriolin depletion affects spindle size and peripheral spindle migration in oocytes., [RefSeq, PubMed]; Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A4W6;A0A4X1;A2AL37;A2AL40;Q6KAR8;Q8CHX3;Q9CRM3", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0090619 meiotic spindle pole;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0001822 kidney development;GO:0003281 ventricular septum development;GO:0035904 aorta development;GO:0060976 coronary vasculature development;GO:0003279 cardiac septum development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A2AL36-1", "record_type": "protein", "filter_code": "0000000.1000110.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TMK6-1", "uniprot_id": [ { "id": "HOOK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TMK6", "type": "external" } ], "mass": 83366.0, "length": 716, "protein_name": "Protein Hook homolog 2", "gene_name": "Hook2", "organism": "Mouse", "refseq_name": "protein Hook homolog 2 isoform 2", "refseq_ac": [ { "id": "NP_001161463", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161463", "type": "external" } ], "gene_names_uniprotkb": "Hook2", "gene_names_refseq": "A630054I03Rik; Hook2; mHK2", "protein_names_uniprotkb": "Protein Hook homolog 2; mHK2", "protein_names_refseq": "protein Hook homolog 2 isoform 2; protein Hook homolog 2", "tax_id": 10090, "disease": "Emery-Dreifuss muscular dystrophy (Disease Ontology:DOID:11726)", "pathway": " (mmu:170833)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17140400;19793914;21750661;25781171;28003339;28283191;34428180", "class_list": "", "function": "Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell., [UniProtKB, UniProtKB]; Results identify Hook2, a linker protein that is essential for regulation of the microtubule network at the centrosome, as a binding partner of CENP-F., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q66JV2;Q8BY47;Q8R347;Q8VCN4;Q99LU2", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0051959 dynein light intermediate chain binding", "go_cellular_component": "GO:0030897 HOPS complex;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0015031 protein transport;GO:0007032 endosome organization;GO:0007040 lysosome organization;GO:0008333 endosome to lysosome transport;GO:0045022 early endosome to late endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q7TMK6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35279-1", "uniprot_id": [ { "id": "RAB6A_MOUSE", "url": "https://www.uniprot.org/uniprot/P35279", "type": "external" } ], "mass": 23590.0, "length": 208, "protein_name": "Ras-related protein Rab-6A", "gene_name": "Rab6a", "organism": "Mouse", "refseq_name": "ras-related protein Rab-6A isoform 1", "refseq_ac": [ { "id": "NP_001157135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157135", "type": "external" } ], "gene_names_uniprotkb": "Rab6a; MNCb-1660; Rab6", "gene_names_refseq": "2610028L11Rik; Rab6a; Rab6", "protein_names_uniprotkb": "Ras-related protein Rab-6A; 3.6.5.2; Rab-6", "protein_names_refseq": "RAB6, member RAS oncogene family; rab-6; ras-related protein Rab-6A isoform 1; ras-related protein Rab-6A", "tax_id": 10090, "disease": "retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:19346); (R-MMU-6798695); (R-MMU-6811436); (R-MMU-6811440); (R-MMU-8854214); (R-MMU-8873719); (R-MMU-8876198)", "pathway_count": 7, "publication_count": 18, "publication_id_list": "1555775;18997784;20360680;20643351;21183079;21750661;23737971;26740625;30016717;31218450;31219806;33300544;34428180;35820727;36692257;37828378;38830762;9438855", "class_list": "", "function": "Rab6-Mediated Polarized Transport of Synaptic Vesicle Precursors Is Essential for the Establishment of Neuronal Polarity and Brain Formation. Publication Status: Online-Only, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Recruits VPS13B to the Golgi membrane. Plays a role in neuron projection development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; [Should I stay or should I go? Neural stem cell anchorage during cerebral cortex development requires the GTPase RAB6 and dynein]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q542M6;Q8R2Z7;Q8VEE5;Q9JJD4", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019904 protein domain specific binding;GO:0046872 metal ion binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0042147 retrograde transport, endosome to Golgi;GO:0034067 protein localization to Golgi apparatus;GO:1903292 protein localization to Golgi membrane", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P35279-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69Z26-1", "uniprot_id": [ { "id": "CNTN4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69Z26", "type": "external" } ], "mass": 113490.0, "length": 1026, "protein_name": "Contactin-4", "gene_name": "Cntn4", "organism": "Mouse", "refseq_name": "contactin-4 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001103219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103219", "type": "external" } ], "gene_names_uniprotkb": "Cntn4; Kiaa3024", "gene_names_refseq": "9630050B05; Axcam; BIG-2; Cntn4", "protein_names_uniprotkb": "Contactin-4; BIG-2; Brain-derived immunoglobulin superfamily protein 2", "protein_names_refseq": "axonal-associated cell adhesion molecule; brain-derived immunoglobulin superfamily molecule; brain-derived immunoglobulin superfamily protein 2; contactin-4 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:269784)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;20133774;21750661;30899004;33300544;38745463;9221934;9733924", "class_list": "", "function": "CNTN4 modulates neural elongation through interplay with APP., [RefSeq, PubMed]; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 12, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 11, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 12, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 12, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 16, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q14BL8;Q8BRT6;Q8CBD3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0043005 neuron projection;GO:0098552 side of membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007399 nervous system development;GO:0031175 neuron projection development;GO:0045665 negative regulation of neuron differentiation;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q69Z26-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61286-1", "uniprot_id": [ { "id": "HTF4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61286", "type": "external" } ], "mass": 75811.0, "length": 706, "protein_name": "Transcription factor 12", "gene_name": "Tcf12", "organism": "Mouse", "refseq_name": "transcription factor 12 isoform 5", "refseq_ac": [ { "id": "NP_001240794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240794", "type": "external" } ], "gene_names_uniprotkb": "Tcf12; Alf1; Meb", "gene_names_refseq": "A130037E08Rik; ALF1; HEBAlt; HEB; HTF-4; HTF4; ME1; REB; Tcf12; bHLHb20", "protein_names_uniprotkb": "Transcription factor 12; Class A helix-loop-helix transcription factor ME1; DNA-binding protein HTF4; E-box-binding protein; TCF-12; Transcription factor HTF-4", "protein_names_refseq": "DNA-binding protein HTF4; E-box-binding protein; TCF-12; class A helix-loop-helix transcription factor ME1; transcription factor 12 isoform 5; transcription factor HTF-4", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); Pitt-Hopkins syndrome (Disease Ontology:DOID:0060488); craniosynostosis 3 (Disease Ontology:DOID:0061011); hypogonadotropic hypogonadism (Disease Ontology:DOID:0090070); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:21406); (R-MMU-525793); (R-MMU-8939236)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11562365;1321336;18214987;21183079;21750661;25428506;31219806;32782141;34428180;37684687;38839978;8261111", "class_list": "", "function": "Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalon. Publication Status: Online-Only, [RefSeq, PubMed]; Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators., [RefSeq, PubMed]; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (PubMed:18214987). May be involved in the functional network that regulates the development of the GnRH axis (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 5, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9QPN4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0046332 SMAD binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q61286-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0P8-1", "uniprot_id": [ { "id": "IFT27_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0P8", "type": "external" } ], "mass": 20814.0, "length": 186, "protein_name": "Intraflagellar transport protein 27 homolog", "gene_name": "Ift27", "organism": "Mouse", "refseq_name": "intraflagellar transport protein 27 homolog", "refseq_ac": [ { "id": "NP_080207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080207", "type": "external" } ], "gene_names_uniprotkb": "Ift27; Rabl4; Rayl", "gene_names_refseq": "2600013G09Rik; Ift27; Rabl4", "protein_names_uniprotkb": "Intraflagellar transport protein 27 homolog; Putative GTP-binding protein RAY-like; Rab-like protein 4", "protein_names_refseq": "RAB, member of RAS oncogene family-like 4; intraflagellar transport protein 27 homolog; rab-like protein 4", "tax_id": 10090, "disease": "Bardet-Biedl syndrome 19 (Disease Ontology:DOID:0110141); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:67042); (R-MMU-5620924)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "19253336;21750661;23055941;23810713;25446516;28430876;28964737;29626631", "class_list": "", "function": "Findings suggest that like IFT25, IFT27, even though not required for ciliogenesis in somatic cells, is essential for sperm flagella formation, sperm function, and male fertility in mice. IFT25 and IFT27 control sperm formation/function through many common mechanisms, but IFT25 has additional roles beyond IFT27., [RefSeq, PubMed]; Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6 (PubMed:25446516). Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6. Required for hedgehog signaling (PubMed:25446516). Forms a subcomplex within the IFT complex B with IFT25 (By similarity). Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation (PubMed:28964737). Plays a role in the early development of the kidney (PubMed:29626631). May be involved in the regulation of ureteric bud initiation (PubMed:29626631)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; This work indicates that IFT25 and IFT27 are important players in the early development of the kidney and suggest that duplex kidney is part of the ciliopathy spectrum., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007283 spermatogenesis;GO:0001822 kidney development;GO:0060271 cilium assembly;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D0P8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CIM7-1", "uniprot_id": [ { "id": "CP2DQ_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CIM7", "type": "external" } ], "mass": 56976.0, "length": 500, "protein_name": "Cytochrome P450 2D26", "gene_name": "Cyp2d26", "organism": "Mouse", "refseq_name": "cytochrome P450 2D26", "refseq_ac": [ { "id": "NP_083838", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083838", "type": "external" } ], "gene_names_uniprotkb": "Cyp2d26; Cyp2d-26", "gene_names_refseq": "1300006E06Rik; Cyp2d26", "protein_names_uniprotkb": "Cytochrome P450 2D26; 1.14.14.1; CYPIID26", "protein_names_refseq": "CYPIID26; cytochrome P450 2D26; cytochrome P450, 2d26", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); extrapyramidal and movement disease (Disease Ontology:DOID:13839); major depressive disorder (Disease Ontology:DOID:1470); autoimmune hepatitis (Disease Ontology:DOID:2048); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); rhinitis (Disease Ontology:DOID:4483); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:76279)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;30084848;34428180;37453647", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DBJ5", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" } ], "go_molecular_function": "GO:0070330 aromatase activity;GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0009410 response to xenobiotic stimulus;GO:0019369 arachidonate metabolic process;GO:0007565 female pregnancy;GO:0033595 response to genistein", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CIM7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48455-1", "uniprot_id": [ { "id": "PP2BC_MOUSE", "url": "https://www.uniprot.org/uniprot/P48455", "type": "external" } ], "mass": 58699.0, "length": 513, "protein_name": "Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform", "gene_name": "Ppp3cc", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 2", "refseq_ac": [ { "id": "NP_032941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032941", "type": "external" } ], "gene_names_uniprotkb": "Ppp3cc; Calnc", "gene_names_refseq": "Calnc; PP2BA gamma; Ppp3cc", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform; 3.1.3.16; CAM-PRP catalytic subunit; Calcineurin, testis-specific catalytic subunit; Calmodulin-dependent calcineurin A subunit gamma isoform", "protein_names_refseq": "CAM-PRP catalytic subunit; calcineurin, testis-specific catalytic subunit; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 2", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:19057); (R-MMU-111447)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1309945;16286645;21750661;31696965;34203471;34428180", "class_list": "", "function": "Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V074", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0033192 calmodulin-dependent protein phosphatase activity;GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0004723 calcium-dependent protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0097226 sperm mitochondrial sheath;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:1900244 positive regulation of synaptic vesicle endocytosis;GO:0006470 protein dephosphorylation;GO:0070886 positive regulation of calcineurin-NFAT signaling cascade;GO:0007341 penetration of zona pellucida", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P48455-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJ93-1", "uniprot_id": [ { "id": "CN119_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJ93", "type": "external" } ], "mass": 16005.0, "length": 142, "protein_name": "Uncharacterized protein C14orf119 homolog", "gene_name": "1700123O20Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein C14orf119 homolog", "refseq_ac": [ { "id": "NP_067412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067412", "type": "external" } ], "gene_names_uniprotkb": "1700123O20Rik; MNCb-2990", "gene_names_refseq": "1700123O20Rik; MNCb-2990", "protein_names_uniprotkb": "Uncharacterized protein C14orf119 homolog", "protein_names_refseq": "uncharacterized protein C14orf119 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:58248)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q921Q2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JJ93-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01065-1", "uniprot_id": [ { "id": "PDE1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q01065", "type": "external" } ], "mass": 61226.0, "length": 535, "protein_name": "Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B", "gene_name": "Pde1b", "organism": "Mouse", "refseq_name": "dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1", "refseq_ac": [ { "id": "NP_032826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032826", "type": "external" } ], "gene_names_uniprotkb": "Pde1b; Pde1b1", "gene_names_refseq": "Pde1b1; Pde1b", "protein_names_uniprotkb": "Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; 3.1.4.17; 63 kDa Cam-PDE; Cam-PDE 1B", "protein_names_refseq": "63 kDa Cam-PDE; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; cam-PDE 1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; phosphodiesterase 1B, Ca2+-calmodulin dependent, 63 kDa; phosphodiesterase 1B1, Ca2+-calmodulin dependent, 63 kDa", "tax_id": 10090, "disease": "Parkinsonism (Disease Ontology:DOID:0080855)", "pathway": " (mmu:18574); (R-MMU-111957); (R-MMU-418457); (R-MMU-418555)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "1326532;1332068;15345747;21183079;21750661;33300544;34428180;9657856", "class_list": "", "function": "Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35384", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004112 cyclic-nucleotide phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007165 signal transduction;GO:0007626 locomotory behavior;GO:0008542 visual learning;GO:0001975 response to amphetamine;GO:0042428 serotonin metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q01065-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UEB3-1", "uniprot_id": [ { "id": "PUF60_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UEB3", "type": "external" } ], "mass": 60249.0, "length": 564, "protein_name": "Poly(U)-binding-splicing factor PUF60", "gene_name": "Puf60", "organism": "Mouse", "refseq_name": "poly(U)-binding-splicing factor PUF60 isoform c", "refseq_ac": [ { "id": "NP_001158072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158072", "type": "external" } ], "gene_names_uniprotkb": "Puf60; Siahbp1", "gene_names_refseq": "2410104I19Rik; 2810454F19Rik; Puf60; SIAHBP1", "protein_names_uniprotkb": "Poly(U)-binding-splicing factor PUF60; 60 kDa poly(U)-binding-splicing factor", "protein_names_refseq": "60 kDa poly(U)-binding-splicing factor; fuse-binding protein-interacting repressor; poly(U)-binding-splicing factor PUF60 isoform c; poly(U)-binding-splicing factor PUF60", "tax_id": 10090, "disease": "", "pathway": " (mmu:67959); (R-MMU-72163); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "21183079;21750661;26495903;31219806;34428180;40997131", "class_list": "", "function": "DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TGC6;Q91VR6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0030054 cell junction;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006915 apoptotic process;GO:0006376 mRNA splice site recognition;GO:0000380 alternative mRNA splicing, via spliceosome;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3UEB3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YQ3-1", "uniprot_id": [ { "id": "CSDC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YQ3", "type": "external" } ], "mass": 16853.0, "length": 154, "protein_name": "Cold shock domain-containing protein C2", "gene_name": "Csdc2", "organism": "Mouse", "refseq_name": "cold shock domain-containing protein C2", "refseq_ac": [ { "id": "NP_663448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663448", "type": "external" } ], "gene_names_uniprotkb": "Csdc2; Pippin", "gene_names_refseq": "Csdc2; Pippin", "protein_names_uniprotkb": "Cold shock domain-containing protein C2; RNA-binding protein PIPPin", "protein_names_refseq": "RNA-binding protein PIPPin; cold shock domain-containing protein C2", "tax_id": 10090, "disease": "", "pathway": " (mmu:105859)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1F0", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0043488 regulation of mRNA stability", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91YQ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQZ6-1", "uniprot_id": [ { "id": "RPGF4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQZ6", "type": "external" } ], "mass": 115491.0, "length": 1011, "protein_name": "Rap guanine nucleotide exchange factor 4", "gene_name": "Rapgef4", "organism": "Mouse", "refseq_name": "rap guanine nucleotide exchange factor 4 isoform 1", "refseq_ac": [ { "id": "NP_001191094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191094", "type": "external" } ], "gene_names_uniprotkb": "Rapgef4; Cgef2; Epac2", "gene_names_refseq": "1300003D15Rik; 5730402K07Rik; 6330581N18Rik; EPAC 2; Epac-2; Epac2; Rapgef4; mKIAA4040", "protein_names_uniprotkb": "Rap guanine nucleotide exchange factor 4; EPAC 2; Exchange factor directly activated by cAMP 2; Exchange protein directly activated by cAMP 2; cAMP-GEFII; cAMP-dependent Rap1 guanine-nucleotide exchange factor; cAMP-regulated guanine nucleotide exchange factor II", "protein_names_refseq": "cAMP-GEFII; cAMP-dependent Rap1 guanine-nucleotide exchange factor; cAMP-regulated guanine nucleotide exchange factor IIB; exchange factor directly activated by cAMP 2; exchange protein directly activated by cAMP 2; rap guanine nucleotide exchange factor 4 isoform 1", "tax_id": 10090, "disease": "autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (mmu:56508); (R-MMU-354192); (R-MMU-381676); (R-MMU-392517); (R-MMU-422356)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "11056535;11707077;12401793;12469113;18660803;21750661;25428506;33300544;35820727", "class_list": "", "function": "Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Does not seem to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Piccolo serves as a Ca(2+) sensor in exocytosis in pancreatic beta-cells and the formation of a cAMP-GEFII.Rim2.Piccolo complex is important in cAMP-induced insulin secretion, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VIP9;Q9CW52;Q9Z1P0", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0044877 protein-containing complex binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0030552 cAMP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0014069 postsynaptic density", "go_biological_process": "GO:0032486 Rap protein signal transduction;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0050714 positive regulation of protein secretion;GO:0050796 regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9EQZ6-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCX8-1", "uniprot_id": [ { "id": "IYD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCX8", "type": "external" } ], "mass": 32814.0, "length": 285, "protein_name": "Iodotyrosine deiodinase 1", "gene_name": "Iyd", "organism": "Mouse", "refseq_name": "iodotyrosine deiodinase 1", "refseq_ac": [ { "id": "NP_081667", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081667", "type": "external" } ], "gene_names_uniprotkb": "Iyd; Dehal1", "gene_names_refseq": "0610009A07Rik; Dehal1; IYD-1; Iyd", "protein_names_uniprotkb": "Iodotyrosine deiodinase 1; 1.21.1.1; IYD-1; Iodotyrosine dehalogenase 1", "protein_names_refseq": "iodotyrosine dehalogenase 1 protein; iodotyrosine deiodinase 1", "tax_id": 10090, "disease": "thyroid dyshormonogenesis 4 (Disease Ontology:DOID:0112188)", "pathway": " (mmu:70337); (R-MMU-209968)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "19436071;19777994;22238141;24153409", "class_list": "", "function": "At least for Metazoa, IYD should provide a new marker for tracing the evolutionary development of iodinated amino acids as regulatory signals through the tree of life., [RefSeq, PubMed]; Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine (By similarity). During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT) (PubMed:22238141). The scavanged iodide can then reenter the hormone-producing pathways (By similarity). Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine (By similarity)., [UniProtKB, PubMed, UniProtKB]; Data show that the structures provide a molecular basis for understanding thyroid disease based on mutations of IYD., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.21.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.21.1.1", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0010181 FMN binding;GO:0140616 iodotyrosine deiodinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0042403 thyroid hormone metabolic process;GO:0006570 tyrosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DCX8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80UQ2-1", "uniprot_id": [ { "id": "RASF6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80UQ2", "type": "external" } ], "mass": 39873.0, "length": 341, "protein_name": "Ras association domain-containing protein 6", "gene_name": "Rassf6", "organism": "Mouse", "refseq_name": "ras association domain-containing protein 6 isoform 2", "refseq_ac": [ { "id": "NP_001297585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297585", "type": "external" } ], "gene_names_uniprotkb": "Rassf6", "gene_names_refseq": "1600016B17Rik; Rassf6", "protein_names_uniprotkb": "Ras association domain-containing protein 6", "protein_names_refseq": "ras association domain-containing protein 6 isoform 2; ras association domain-containing protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:73246)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17404571;21183079;21750661;23626755;31219806;34652874", "class_list": "", "function": "Characterization of mouse embryonic fibroblasts derived from Rassf6 knockout mice shows the implication of Rassf6 in the regulation of NF-kappaB signaling., [RefSeq, PubMed]; Demonstrates properties of a Ras effector and tumor suppressor but exhibits biological properties that are unique and distinct from those of other family members., [RefSeq, PubMed]; Involved in the induction of apoptosis. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B., [UniProtKB, PubMed]; RASSF6 expression in adipocytes is down-regulated by interaction with macrophages. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3X8Z9;Q9DAW2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80UQ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80Y50-1", "uniprot_id": [ { "id": "CMTA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80Y50", "type": "external" } ], "mass": 132010.0, "length": 1208, "protein_name": "Calmodulin-binding transcription activator 2", "gene_name": "Camta2", "organism": "Mouse", "refseq_name": "calmodulin-binding transcription activator 2 isoform 2", "refseq_ac": [ { "id": "NP_001177305", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177305", "type": "external" } ], "gene_names_uniprotkb": "Camta2; Kiaa0909", "gene_names_refseq": "Camta2; Kiaa0909-hp; mKIAA0909", "protein_names_uniprotkb": "Calmodulin-binding transcription activator 2", "protein_names_refseq": "calmodulin-binding transcription activator 2 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:216874)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Transcription activator. May act as tumor suppressor (By similarity)., [UniProtKB]; Transcription activator. May act as tumor suppressor., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0QZH5;Q3TFK0;Q5SX54;Q5SX68;Q6PHS5;Q80TP1;Q8R0D9;Q8R2N5", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0042826 histone deacetylase binding;GO:0003690 double-stranded DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0014898 cardiac muscle hypertrophy in response to stress", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80Y50-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUM4-1", "uniprot_id": [ { "id": "COR1C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUM4", "type": "external" } ], "mass": 53121.0, "length": 474, "protein_name": "Coronin-1C", "gene_name": "Coro1c", "organism": "Mouse", "refseq_name": "coronin-1C", "refseq_ac": [ { "id": "NP_035909", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035909", "type": "external" } ], "gene_names_uniprotkb": "Coro1c", "gene_names_refseq": "CRN2; Coro1c", "protein_names_uniprotkb": "Coronin-1C; Coronin-3", "protein_names_refseq": "coronin 1c; coronin-1C; coronin-3", "tax_id": 10090, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); proliferative diabetic retinopathy (Disease Ontology:DOID:13207)", "pathway": " (mmu:23790)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "18034455;19651142;21750661;22364218;22645316;23806337;25074804;25153642;25428506;25925950;27178841;28528544;30084848;30779550;34428180;34887587;35657370;35743062;35820727;37507081;9778037", "class_list": "", "function": "Coro1B and Coro1C regulate lamellipodia dynamics and cell motility by tuning branched actin turnover., [RefSeq, PubMed]; Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (PubMed:27178841). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (PubMed:27178841). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission. Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (By similarity). Required for normal distribution of mitochondria within cells (PubMed:27178841). Interacts with GDP-bound RAB44 in bone marrow macrophages to promote osteoclastogenesis (PubMed:35743062). Involved in the migration and chemotaxis of macrophages (PubMed:35743062)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q499X7;Q8VCQ5", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:1900027 regulation of ruffle assembly;GO:0010633 negative regulation of epithelial cell migration;GO:0010762 regulation of fibroblast migration;GO:1900024 regulation of substrate adhesion-dependent cell spreading;GO:0051893 regulation of focal adhesion assembly", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9WUM4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8WUR0-1", "uniprot_id": [ { "id": "CS012_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8WUR0", "type": "external" } ], "mass": 15087.0, "length": 141, "protein_name": "Protein C19orf12 homolog", "gene_name": "1600014C10Rik", "organism": "Mouse", "refseq_name": "protein C19orf12 homolog", "refseq_ac": [ { "id": "NP_001078854", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078854", "type": "external" } ], "gene_names_uniprotkb": "1600014C10Rik", "gene_names_refseq": "1600014C10Rik", "protein_names_uniprotkb": "Protein C19orf12 homolog", "protein_names_refseq": "protein C19orf12 homolog", "tax_id": 10090, "disease": "neurodegeneration with brain iron accumulation 4 (Disease Ontology:DOID:0110738); hereditary spastic paraplegia 43 (Disease Ontology:DOID:0110795)", "pathway": " (mmu:72244)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Adipocyte protein localized at lipid droplet-mitochondria contact sites that governs lipid storage through regulation of mitochondrial fatty acid metabolism., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q58E27;Q8K308;Q9DAX5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0006915 apoptotic process;GO:0006914 autophagy;GO:0051560 mitochondrial calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8WUR0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4VA45-1", "uniprot_id": [ { "id": "ZFTA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4VA45", "type": "external" } ], "mass": 73710.0, "length": 678, "protein_name": "Zinc finger translocation-associated protein", "gene_name": "Zfta", "organism": "Mouse", "refseq_name": "zinc finger translocation-associated protein isoform 1", "refseq_ac": [ { "id": "NP_780590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780590", "type": "external" } ], "gene_names_uniprotkb": "Zfta; 2700081O15Rik", "gene_names_refseq": "2700081O15Rik; Zfta", "protein_names_uniprotkb": "Zinc finger translocation-associated protein; ZFTA", "protein_names_refseq": "uncharacterized protein C11orf95 homolog; zinc finger translocation-associated protein isoform 1; zinc finger translocation-associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:108899)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;31219806;33685520;35087169", "class_list": "", "function": "C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation. Erratum:[Acta Neuropathol Commun. 2021 May 27;9(1):100. doi: 10.1186/s40478-021-01157-y. PMID: 34044883] Publication Status: Online-Only, [RefSeq, PubMed]; Ependymoma associated protein Zfta is expressed in immature ependymal cells but is not essential for ependymal development in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4VA45-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BLX7-1", "uniprot_id": [ { "id": "COGA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BLX7", "type": "external" } ], "mass": 155805.0, "length": 1580, "protein_name": "Collagen alpha-1(XVI) chain", "gene_name": "Col16a1", "organism": "Mouse", "refseq_name": "collagen alpha-1(XVI) chain isoform 1 precursor", "refseq_ac": [ { "id": "NP_082542", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082542", "type": "external" } ], "gene_names_uniprotkb": "Col16a1", "gene_names_refseq": "2700007F12Rik; A530052M23Rik; CA1F; Col16a1", "protein_names_uniprotkb": "Collagen alpha-1(XVI) chain", "protein_names_refseq": "[a]1 (XVI) collagen; collagen alpha-1(XVI) chain isoform 1 precursor; collagen alpha-1(XVI) chain; procollagen type XVI alpha 1", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:107581); (R-MMU-1650814); (R-MMU-216083); (R-MMU-8948216)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;16754661;21750661;31219806;34428180;8650669", "class_list": "", "function": "Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; There is a unique alpha1 beta1 integrin-binding site within collagen XVI located close to its C-terminal end, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 1, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A3KFV5;Q9CZS2", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0001527 microfibril", "go_biological_process": "GO:0007155 cell adhesion;GO:0030198 extracellular matrix organization;GO:0033627 cell adhesion mediated by integrin;GO:0051894 positive regulation of focal adhesion assembly;GO:0071230 cellular response to amino acid stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BLX7-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DC11-1", "uniprot_id": [ { "id": "PXDC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DC11", "type": "external" } ], "mass": 59616.0, "length": 530, "protein_name": "Plexin domain-containing protein 2", "gene_name": "Plxdc2", "organism": "Mouse", "refseq_name": "plexin domain-containing protein 2 precursor", "refseq_ac": [ { "id": "NP_080438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080438", "type": "external" } ], "gene_names_uniprotkb": "Plxdc2; Tem7r", "gene_names_refseq": "1200007L24Rik; 5430431D22Rik; Plxdc2; Tem7r", "protein_names_uniprotkb": "Plexin domain-containing protein 2; Tumor endothelial marker 7-related protein", "protein_names_refseq": "plexin domain-containing protein 2 precursor; plexin domain-containing protein 2; tumor endothelial marker 7 related; tumor endothelial marker 7-related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67448)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11559528;15574754;21183079;21750661;32661418;34428180", "class_list": "", "function": "Identification of new regulatory genes through expression pattern analysis of a global RNA-seq dataset from a Helicobacter pylori co-culture system. Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in tumor angiogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6PET5;Q91ZV6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0016604 nuclear body;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9DC11-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MI1-1", "uniprot_id": [ { "id": "RB6I2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MI1", "type": "external" } ], "mass": 128331.0, "length": 1120, "protein_name": "ELKS/Rab6-interacting/CAST family member 1", "gene_name": "Erc1", "organism": "Mouse", "refseq_name": "ELKS/Rab6-interacting/CAST family member 1 isoform 2", "refseq_ac": [ { "id": "NP_835186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_835186", "type": "external" } ], "gene_names_uniprotkb": "Erc1; Cast2; Kiaa1081; Rab6ip2", "gene_names_refseq": "4930404L01Rik; 5033405M01Rik; 9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1; Erc1; RAB6IP2A; RAB6IP2B; Rab6ip2; mKIAA1081", "protein_names_uniprotkb": "ELKS/Rab6-interacting/CAST family member 1; CAST2; CAZ-associated structural protein 2; ERC-1; Rab6-interacting protein 2", "protein_names_refseq": "CAZ-associated structural protein 2; ELKS/Rab6-interacting/CAST family member 1 isoform 2; RAB6-interacting protein 2; Rab6 interacting protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:111173)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11929610;14723704;21183079;21750661;22517741;22645316;22826440;23525008;23806337;31219806;34428180;40885482", "class_list": "", "function": "Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex (By similarity). May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q80TK7;Q8BPL1;Q8C7Y1;Q99MI2", "ec_number_list": [], "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone;GO:0031267 small GTPase binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0000139 Golgi membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0048790 maintenance of presynaptic active zone structure;GO:0015031 protein transport;GO:0006355 regulation of DNA-templated transcription;GO:0042147 retrograde transport, endosome to Golgi;GO:0099509 regulation of presynaptic cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q99MI1-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WU79-1", "uniprot_id": [ { "id": "PROD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WU79", "type": "external" } ], "mass": 68036.0, "length": 599, "protein_name": "Proline dehydrogenase 1, mitochondrial", "gene_name": "Prodh", "organism": "Mouse", "refseq_name": "proline dehydrogenase 1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_035302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035302", "type": "external" } ], "gene_names_uniprotkb": "Prodh; Pro1", "gene_names_refseq": "Pro-1; Pro1; Prodh; Ym24d07", "protein_names_uniprotkb": "Proline dehydrogenase 1, mitochondrial; 1.5.5.2; Proline oxidase", "protein_names_refseq": "proline dehydrogenase 1, mitochondrial precursor; proline dehydrogenase 1, mitochondrial; proline dehydrogenase, mitochondrial; proline oxidase", "tax_id": 10090, "disease": "chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); schizophrenia 4 (Disease Ontology:DOID:0070080); hyperprolinemia type 1 (Disease Ontology:DOID:0080542); schizophrenia (Disease Ontology:DOID:5419); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (mmu:19125); (R-MMU-70688)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10192398;21750661;23576753;27705802;28685754;30084848;31219806;34428180;35820727;37453647", "class_list": "", "function": "Converts proline to delta-1-pyrroline-5-carboxylate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Here, we show that Prodh-deficient mice with elevated CNS L-proline display specific deficits in high-frequency GABA-ergic transmission and gamma-band oscillations. We find that L-proline is a GABA-mimetic and can act at multiple GABA-ergic targets, [RefSeq, PubMed]; PRODH1-mediated proline metabolism promotes pancreatic ductal adenocarcinoma growth. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0JLW6;Q3UNR4;Q9QX61", "ec_number_list": [ { "id": "1.5.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.5.3", "type": "external" }, { "id": "1.5.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.5.2", "type": "external" } ], "go_molecular_function": "GO:0071949 FAD binding;GO:0016597 amino acid binding;GO:0004657 proline dehydrogenase activity;GO:0016649 oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:1903376 regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;GO:0010133 L-proline catabolic process to L-glutamate;GO:0006562 L-proline catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9WU79-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGA0-1", "uniprot_id": [ { "id": "PPM1F_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CGA0", "type": "external" } ], "mass": 49611.0, "length": 452, "protein_name": "Protein phosphatase 1F", "gene_name": "Ppm1f", "organism": "Mouse", "refseq_name": "protein phosphatase 1F", "refseq_ac": [ { "id": "NP_789803", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789803", "type": "external" } ], "gene_names_uniprotkb": "Ppm1f", "gene_names_refseq": "1110021B16Rik; 4933427B07Rik; CaMKPase; Popx2; Ppm1f; mKIAA0015", "protein_names_uniprotkb": "Protein phosphatase 1F; 3.1.3.16; Ca(2+)/calmodulin-dependent protein kinase phosphatase; CaM-kinase phosphatase; CaMKPase", "protein_names_refseq": "ca(2+)/calmodulin-dependent protein kinase phosphatase; caM-kinase phosphatase; calcium/calmodulin-dependent protein kinase phosphatase; partner of PIX2; protein phosphatase 1F", "tax_id": 10090, "disease": "", "pathway": " (mmu:68606)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "18230650;20016286;21750661;26386307;28135057;29054677;30250217;33119040;33639208;33745117;35820727;37309288", "class_list": "", "function": "C-terminal cytoplasmic fragment of PcdhgC5 acts as a scaffold for CaMKP and CaMKI to regulate CaMKP activity., [RefSeq, PubMed]; Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis (By similarity)., [UniProtKB]; Medial prefrontal cortical PPM1F alters depression-related behaviors by modifying p300 activity via the AMPK signaling pathway., [RefSeq, PubMed]; PPM1F controls integrin activity via a conserved phospho-switch., [RefSeq, PubMed]; PPM1F in Dentate Gyrus Modulates Anxiety-Related Behaviors by Regulating BDNF Expression via AKT/JNK/p-H3S10 Pathway., [RefSeq, PubMed]; PPM1F in hippocampal dentate gyrus regulates the depression-related behaviors by modulating neuronal excitability., [RefSeq, PubMed]; Ppm1f is involved in stress- and trauma-related manifestation of anxiety and depression., [RefSeq, PubMed]; The POPX2 phosphatase regulates cancer cell motility and invasiveness., [RefSeq, PubMed]; The binding of POPX2 (PPM1F) to mDia1 or to an mDia-containing complex greatly decreases the ability of mDia1 to activate transcription from the serum response element (SRE)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0033192 calmodulin-dependent protein phosphatase activity;GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007165 signal transduction;GO:0010628 positive regulation of gene expression;GO:0030335 positive regulation of cell migration;GO:0035556 intracellular signal transduction;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8CGA0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64010-1", "uniprot_id": [ { "id": "CRK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64010", "type": "external" } ], "mass": 33815.0, "length": 304, "protein_name": "Adapter molecule crk", "gene_name": "Crk", "organism": "Mouse", "refseq_name": "adapter molecule crk isoform 2", "refseq_ac": [ { "id": "NP_598417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598417", "type": "external" } ], "gene_names_uniprotkb": "Crk; Crko", "gene_names_refseq": "Crk-III; Crk-II; Crk-I; Crk3; CrkIII; Crko; Crk; c-Crk; p38", "protein_names_uniprotkb": "Adapter molecule crk; Proto-oncogene c-Crk; p38", "protein_names_refseq": "CT-10 related kinase 3; adapter molecule crk isoform 2; adapter molecule crk; avian sarcoma virus CT10 (v-crk) oncogene homolog; proto-oncogene c-crk; v-crk avian sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene-like protein", "tax_id": 10090, "disease": "degenerative disc disease (Disease Ontology:DOID:90)", "pathway": " (mmu:12928); (R-MMU-170984); (R-MMU-186763); (R-MMU-2029482); (R-MMU-372708); (R-MMU-4420097); (R-MMU-8849471); (R-MMU-8875555); (R-MMU-8875656); (R-MMU-912631)", "pathway_count": 10, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;10854253;11870224;12842890;12878163;1409582;15345747;15886098;16880535;17242355;18034455;19381274;21750661;2450282;25428506;28974561;37702066;7735837;8183562;8194526;9395447;9480911;9722576;9819391;9851931", "class_list": "", "function": "Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development., [RefSeq, PubMed]; Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1., [UniProtKB, UniProtKB]; Isoform CRK-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (By similarity). May regulate the EFNA5-EPHA3 signaling (PubMed:11870224)., [UniProtKB, UniProtKB, PubMed]; The authors cloned SH2 domain-containing proteins they named GRBs (for growth factor receptor-bound). They identified GRB-3 as having 77% identity at the protein level and 80% similarity at the DNA level to v-crk., [RefSeq, PubMed]; The authors cloned and sequenced the avian sarcoma virus CT10 from infected QT6 quail cells then demonstrated that the protein p47 phosphorylates tyrosine residues and can modulate activity of tyrosine kinases. They name the oncogene crk for CT10 regulator of kinase., [RefSeq, PubMed]; These data indicate that Crk is involved in cardiac and craniofacial development and that it plays an essential role in maintaining vascular integrity during embryonic development., [RefSeq, PubMed]; This gene is part of a family of adapter proteins that mediate formation of signal transduction complexes in response to extracellular stimuli, such as growth and differentiation factors. Protein-protein interactions occur through the SH2 domain, which binds phosphorylated tyrosine residues, and the SH3 domain, which binds proline-rich peptide motifs. These interactions promote recruitment and activation of effector proteins to regulate cell migration, adhesion, and proliferation. In mouse this protein is essential for embryonic development. Alternatively spliced transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Mar 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9261, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0017124 SH3 domain binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0016020 membrane", "go_biological_process": "GO:0033628 regulation of cell adhesion mediated by integrin;GO:0035728 response to hepatocyte growth factor;GO:0061847 response to cholecystokinin;GO:1990859 cellular response to endothelin;GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q64010-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TPA8-1", "uniprot_id": [ { "id": "HSDL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q2TPA8", "type": "external" } ], "mass": 54208.0, "length": 490, "protein_name": "Hydroxysteroid dehydrogenase-like protein 2", "gene_name": "Hsdl2", "organism": "Mouse", "refseq_name": "hydroxysteroid dehydrogenase-like protein 2 isoform 1", "refseq_ac": [ { "id": "NP_077217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077217", "type": "external" } ], "gene_names_uniprotkb": "Hsdl2", "gene_names_refseq": "2610207I16Rik; Hsdl2", "protein_names_uniprotkb": "Hydroxysteroid dehydrogenase-like protein 2; 1.-.-.-", "protein_names_refseq": "hydroxysteroid dehydrogenase-like protein 2 isoform 1; hydroxysteroid dehydrogenase-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72479)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "16240713;19372376;21750661;23576753;23806337;30084848;34428180;36288343;37453647;37507081;38820148", "class_list": "", "function": "HSDL2 links nutritional cues to bile acid and cholesterol homeostasis., [RefSeq, PubMed]; Has apparently no steroid dehydrogenase activity. Controls bile acid (BA) and lipid metabolism in response to nutritional cues., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Hsdl2 is widely expressed in normal mouse tissues and its expression level in liver increases after inducement with cholesterol food., [RefSeq, PubMed]; Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~35%., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ULY5;Q3UVZ3;Q8C3H3;Q99LV2", "ec_number_list": [], "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome", "go_biological_process": "GO:0042632 cholesterol homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q2TPA8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VB4-1", "uniprot_id": [ { "id": "HPS3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VB4", "type": "external" } ], "mass": 113182.0, "length": 1002, "protein_name": "BLOC-2 complex member HPS3", "gene_name": "Hps3", "organism": "Mouse", "refseq_name": "BLOC-2 complex member HPS3 isoform 2", "refseq_ac": [ { "id": "NP_001139795", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139795", "type": "external" } ], "gene_names_uniprotkb": "Hps3; Coa", "gene_names_refseq": "Hps3; coa", "protein_names_uniprotkb": "BLOC-2 complex member HPS3; Cocoa protein; Hermansky-Pudlak syndrome 3 protein homolog", "protein_names_refseq": "BLOC-2 complex member HPS3 isoform 2; BLOC-2 complex member HPS3; Hermansky-Pudlak syndrome 3 homolog; cocoa protein; hermansky-Pudlak syndrome 3 protein homolog", "tax_id": 10090, "disease": "Hermansky-Pudlak syndrome 3 (Disease Ontology:DOID:0060541); platelet storage pool deficiency (Disease Ontology:DOID:2223); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": " (mmu:12807)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11592818;11707070;21750661", "class_list": "", "function": "Involved in early stages of melanosome biogenesis and maturation., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6GTD8;Q8VDX2;Q8VHT1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0031084 BLOC-2 complex", "go_biological_process": "GO:1903232 melanosome assembly;GO:0060155 platelet dense granule organization;GO:0043473 pigmentation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91VB4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BUK6-1", "uniprot_id": [ { "id": "HOOK3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BUK6", "type": "external" } ], "mass": 83218.0, "length": 718, "protein_name": "Protein Hook homolog 3", "gene_name": "Hook3", "organism": "Mouse", "refseq_name": "protein Hook homolog 3", "refseq_ac": [ { "id": "NP_997542", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997542", "type": "external" } ], "gene_names_uniprotkb": "Hook3", "gene_names_refseq": "5830454D03Rik; E330005F07Rik; Hook3", "protein_names_uniprotkb": "Protein Hook homolog 3; mHK3", "protein_names_refseq": "hook homolog 3; mHK3; protein Hook homolog 3", "tax_id": 10090, "disease": "Emery-Dreifuss muscular dystrophy (Disease Ontology:DOID:11726)", "pathway": " (mmu:320191)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11238449;12950921;15075236;17140400;17237231;21183079;21750661;27365401;28003339;28283191;34428180", "class_list": "", "function": "(Microbial infection) Serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking., [UniProtKB, PubMed]; Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell., [UniProtKB, UniProtKB]; Hook3 interacts with a cytoplasmic domain of scavenger receptor A, [RefSeq, PubMed]; Identified hook3 as the first cooperation partner of a member of the 47 kDa GTPase protein family (IIGP) and indicated that hook3 links in an IFNgamma-inducible fashion to cytoskeleton-based membrane trafficking., [RefSeq, PubMed]; Single-molecule motility assays using total internal reflection fluorescence microscopy indicate that both Hook1 and Hook3 effectively activate cytoplasmic dynein, inducing longer run lengths and higher velocities than the previously characterized dynein activator bicaudal D2 (BICD2)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q540A0;Q8BV48;Q8BW57;Q8BY41", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0034452 dynactin binding;GO:0051959 dynein light intermediate chain binding;GO:0045503 dynein light chain binding", "go_cellular_component": "GO:0030897 HOPS complex;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005874 microtubule", "go_biological_process": "GO:0015031 protein transport;GO:0007032 endosome organization;GO:0007040 lysosome organization;GO:0008333 endosome to lysosome transport;GO:0045022 early endosome to late endosome transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8BUK6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60668-1", "uniprot_id": [ { "id": "HNRPD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60668", "type": "external" } ], "mass": 38354.0, "length": 355, "protein_name": "Heterogeneous nuclear ribonucleoprotein D0", "gene_name": "Hnrnpd", "organism": "Mouse", "refseq_name": "heterogeneous nuclear ribonucleoprotein D0 isoform a", "refseq_ac": [ { "id": "NP_001070733", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070733", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpd; Auf1; Hnrpd", "gene_names_refseq": "Auf1; Hnrnpd; Hnrpd", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein D0; AU-rich element RNA-binding protein 1; hnRNP D0", "protein_names_refseq": "AU-rich element RNA-binding protein 1; heterogeneous nuclear ribonucleoprotein D0 isoform a; heterogeneous nuclear ribonucleoprotein D0; hnRNP D0", "tax_id": 10090, "disease": "uremia (Disease Ontology:DOID:4676); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:11991); (R-MMU-450408); (R-MMU-72163); (R-MMU-72203); (R-MMU-9770562)", "pathway_count": 5, "publication_count": 19, "publication_id_list": "12107167;19144319;21183079;21750661;23806337;24129315;26495903;33300544;33725478;34428180;35391558;35984892;36601302;37453647;37507081;37989221;39627609;7522249;7959009", "class_list": "", "function": "AUF-1 knockdown in mice undermines gut microbial butyrate-driven hypocholesterolemia through AUF-1-Dicer-1-mir-122 hierarchy. Publication Status: Online-Only, [RefSeq, PubMed]; AUF1 protects against ferroptosis to alleviate sepsis-induced acute lung injury by regulating NRF2 and ATF3. Publication Status: Online-Only, [RefSeq, PubMed]; Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation., [UniProtKB, UniProtKB]; Interaction with lactate dehydrogenase, [RefSeq, PubMed]; RNA binding protein AUF1/HNRNPD regulates nuclear export, stability and translation of SNCA transcripts., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60667;Q80ZJ0;Q91X94", "ec_number_list": [], "go_molecular_function": "GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0045202 synapse", "go_biological_process": "GO:0070934 CRD-mediated mRNA stabilization;GO:2000767 positive regulation of cytoplasmic translation;GO:1904383 response to sodium phosphate;GO:0001889 liver development;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q60668-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NZM9-1", "uniprot_id": [ { "id": "HDAC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NZM9", "type": "external" } ], "mass": 118562.0, "length": 1076, "protein_name": "Histone deacetylase 4", "gene_name": "Hdac4", "organism": "Mouse", "refseq_name": "histone deacetylase 4", "refseq_ac": [ { "id": "NP_997108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997108", "type": "external" } ], "gene_names_uniprotkb": "Hdac4", "gene_names_refseq": "4932408F19Rik; HD4; Hdac4", "protein_names_uniprotkb": "Histone deacetylase 4; 3.5.1.98; HD4", "protein_names_refseq": "histone deacetylase 4", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); stroke (Disease Ontology:DOID:0051061); ataxia telangiectasia (Disease Ontology:DOID:12704); impotence (Disease Ontology:DOID:1875); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); aortic aneurysm (Disease Ontology:DOID:3627); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); retinal degeneration (Disease Ontology:DOID:8466); eating disorder (Disease Ontology:DOID:8670); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:208727); (R-MMU-350054); (R-MMU-4090294); (R-MMU-4551638); (R-MMU-8951936)", "pathway_count": 5, "publication_count": 17, "publication_id_list": "10984530;15601857;17468767;17923476;17949687;19131326;21183079;21590736;21750661;22318228;22730529;23624624;31195810;31219806;34428180;38326336;38657041", "class_list": "", "function": "Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation., [RefSeq, PubMed]; Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Deacetylates HSPA1A and HSPA1A at 'Lys-77' leading to their preferential binding to co-chaperone STUB1., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRZ9;Q3U2J3;Q3V3Y4", "ec_number_list": [ { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.5.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.48", "type": "external" }, { "id": "3.5.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.62", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0048742 regulation of skeletal muscle fiber development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q6NZM9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDM6-1", "uniprot_id": [ { "id": "HNRL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDM6", "type": "external" } ], "mass": 96002.0, "length": 859, "protein_name": "Heterogeneous nuclear ribonucleoprotein U-like protein 1", "gene_name": "Hnrnpul1", "organism": "Mouse", "refseq_name": "heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform 1", "refseq_ac": [ { "id": "NP_659171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659171", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpul1; Hnrpul1", "gene_names_refseq": "E130317O14Rik; E1B-AP5; E1BAP5; Hnrnpul1; Hnrnpul; Hnrpul1", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein U-like protein 1", "protein_names_refseq": "EIB-55kDa associated protein 5; heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform 1; heterogeneous nuclear ribonucleoprotein U-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:232989)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19144319;20485683;21183079;24129315;29187734;31219806;34082786;34428180;34678516;37507081;39627609;39927985;40997131", "class_list": "", "function": "Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Also plays a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro (By similarity)., [UniProtKB]; Dynamics of alternative splicing during somatic cell reprogramming reveals functions for RNA-binding proteins CPSF3, hnRNP UL1, and TIA1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U201;Q3UPB0;Q6AZA7;Q8BY45;Q8K365", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0045202 synapse;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0000380 alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8VDM6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV93-1", "uniprot_id": [ { "id": "HEY1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WV93", "type": "external" } ], "mass": 32063.0, "length": 299, "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 1", "gene_name": "Hey1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hey1; Herp2; Hesr1; Hrt1", "gene_names_refseq": "", "protein_names_uniprotkb": "Hairy/enhancer-of-split related with YRPW motif protein 1; HESR-1; HRT-1; Hairy and enhancer of split-related protein 1; Hairy-related transcription factor 1; mHRT1", "protein_names_refseq": "", "tax_id": 10090, "disease": "hemangiopericytoma (Disease Ontology:DOID:264); hemangioblastoma (Disease Ontology:DOID:5241); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": "", "pathway_count": 0, "publication_count": 17, "publication_id_list": "10403790;10415358;10860664;10964718;11095750;11160397;11486044;11486045;11741889;12947105;14648848;15107403;15680351;16199874;17259303;17303760;34428180", "class_list": "", "function": "Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0072359 circulatory system development;GO:0050678 regulation of epithelial cell proliferation;GO:0003208 cardiac ventricle morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001570 vasculogenesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9WV93-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55135-1", "uniprot_id": [ { "id": "IF6_MOUSE", "url": "https://www.uniprot.org/uniprot/O55135", "type": "external" } ], "mass": 26511.0, "length": 245, "protein_name": "Eukaryotic translation initiation factor 6", "gene_name": "Eif6", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 6", "refseq_ac": [ { "id": "NP_034709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034709", "type": "external" } ], "gene_names_uniprotkb": "Eif6; Itgb4bp", "gene_names_refseq": "1110004P11; CAB; Eif6; Itgb4bp; eIF-6; imc-415; p27(BBP); p27BBP", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 6; B4 integrin interactor; CAB; eIF-6; p27(BBP)", "protein_names_refseq": "B4 integrin interactor; eukaryotic translation initiation factor 6; integrin beta 4 binding protein", "tax_id": 10090, "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16418)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10206977;11290417;12150946;18784653;21536732;21665150;21750661;25428506;26383020;26391622;28135057;28528544;28575669;31599954;32782141;34428180;35887068;36469534;9374518", "class_list": "", "function": "Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR (PubMed:26383020). Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (PubMed:26391622). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (By similarity). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (PubMed:21665150)., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed]; EIF6 is the first eIF associated with the large 60S subunit that regulates translation in response to extracellular signals, [RefSeq, PubMed]; Eukaryotic initiation factor 6 repression mitigates atherosclerosis progression by inhibiting macrophages expressing Fasn., [RefSeq, PubMed]; Inhibition of eIF6 Activity Reduces Hepatocellular Carcinoma Growth: An In Vivo and In Vitro Study. Publication Status: Online-Only, [RefSeq, PubMed]; Role in forming nuclear matrix filaments, [RefSeq, PubMed]; The protein encoded by this gene is a eukaryotic translation initiation factor that regulates both ribosome biogenesis and translation, which are rate-limiting factors for cell growth. The encoded protein binds 60S ribosomes and prevents their association with 40S ribosomes. This gene may play a role in oncogenesis as well. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043022 ribosome binding;GO:0003743 translation initiation factor activity;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006110 regulation of glycolytic process;GO:0042304 regulation of fatty acid biosynthetic process;GO:0000054 ribosomal subunit export from nucleus;GO:0032868 response to insulin;GO:0045652 regulation of megakaryocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "O55135-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60751-1", "uniprot_id": [ { "id": "IGF1R_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60751", "type": "external" } ], "mass": 155788.0, "length": 1373, "protein_name": "Insulin-like growth factor 1 receptor", "gene_name": "Igf1r", "organism": "Mouse", "refseq_name": "insulin-like growth factor 1 receptor precursor", "refseq_ac": [ { "id": "NP_034643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034643", "type": "external" } ], "gene_names_uniprotkb": "Igf1r", "gene_names_refseq": "A330103N21Rik; CD221; D930020L01; IGF-1R; Igf1r; hyft", "protein_names_uniprotkb": "Insulin-like growth factor 1 receptor; 2.7.10.1; IGF-I receptor; Insulin-like growth factor I receptor", "protein_names_refseq": "IGF-I receptor; insulin-like growth factor 1 receptor precursor; insulin-like growth factor 1 receptor; line 186", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); cardiomyopathy (Disease Ontology:DOID:0050700); alcohol dependence (Disease Ontology:DOID:0050741); Zollinger-Ellison syndrome (Disease Ontology:DOID:0050782); stroke (Disease Ontology:DOID:0051061); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); gastroschisis (Disease Ontology:DOID:11044); prostatic hypertrophy (Disease Ontology:DOID:11132); cryptorchidism (Disease Ontology:DOID:11383); osteoporosis (Disease Ontology:DOID:11476); portal vein thrombosis (Disease Ontology:DOID:11695); gestational diabetes (Disease Ontology:DOID:11714); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); Lewy body dementia (Disease Ontology:DOID:12217); Graves' disease (Disease Ontology:DOID:12361); dementia (Disease Ontology:DOID:1307); alcoholic neuropathy (Disease Ontology:DOID:14183); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); nephroblastoma (Disease Ontology:DOID:2154); prostate adenocarcinoma (Disease Ontology:DOID:2526); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); toxic encephalopathy (Disease Ontology:DOID:3602); glucose metabolism disease (Disease Ontology:DOID:4194); coronary stenosis (Disease Ontology:DOID:4248); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); liver cirrhosis (Disease Ontology:DOID:5082); sleep disorder (Disease Ontology:DOID:535); gastrinoma (Disease Ontology:DOID:5577); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); neuroblastoma (Disease Ontology:DOID:769); hyperthyroidism (Disease Ontology:DOID:7998); osteoarthritis (Disease Ontology:DOID:8398); ulcerative colitis (Disease Ontology:DOID:8577); vascular dementia (Disease Ontology:DOID:8725); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); vesicoureteral reflux (Disease Ontology:DOID:9620); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16001); (R-MMU-2404192); (R-MMU-2428928); (R-MMU-2428933); (R-MMU-9009391)", "pathway_count": 5, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10671200;11884589;19349973;19656770;21750661;22685298;2482828;25428506;25428507;26692333;30084848;30899004;33300544;34203471;34428180;8234298;8402901", "class_list": "", "function": "Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R (By similarity). When present in a hybrid receptor with INSR, binds IGF1 (By similarity)., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 11, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 9, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 11, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 11, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 54, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "O70438;Q62123", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0005009 insulin receptor activity;GO:0004713 protein tyrosine kinase activity;GO:0005158 insulin receptor binding;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex;GO:0005730 nucleolus;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:1903944 negative regulation of hepatocyte apoptotic process;GO:0048680 positive regulation of axon regeneration;GO:0051446 positive regulation of meiotic cell cycle;GO:0006468 protein phosphorylation;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "Q60751-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D4G2-1", "uniprot_id": [ { "id": "HSF2B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D4G2", "type": "external" } ], "mass": 37963.0, "length": 338, "protein_name": "Heat shock factor 2-binding protein", "gene_name": "Hsf2bp", "organism": "Mouse", "refseq_name": "heat shock factor 2-binding protein", "refseq_ac": [ { "id": "NP_083178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083178", "type": "external" } ], "gene_names_uniprotkb": "Hsf2bp; Meilb2", "gene_names_refseq": "4932437G14Rik; Hsf2bp; Meilb2", "protein_names_uniprotkb": "Heat shock factor 2-binding protein", "protein_names_refseq": "heat shock factor 2-binding protein; meiotic localizer of BRCA2", "tax_id": 10090, "disease": "primary ovarian insufficiency 19 (Disease Ontology:DOID:0112278)", "pathway": " (mmu:74377)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21750661;23707421;30760716;31242413;32345962;32460033;32463460;32845237;36167792", "class_list": "", "function": "A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1. Publication Status: Online-Only, [RefSeq, PubMed]; HSF2BP may play a pivotal role in regulating BNC1 transcriptional activity and subcellular localization during spermatogenesis., [RefSeq, PubMed]; HSF2BP protects against acute liver injury by regulating HSF2/HSP70/MAPK signaling in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility (PubMed:30760716, PubMed:31242413, PubMed:32345962, PubMed:32463460). Required for proper recombinase recruitment in female meiosis (PubMed:30760716, PubMed:32845237). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (PubMed:23707421). May be involved in modulating HSF2 activation in testis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005694 chromosome", "go_biological_process": "GO:0007144 female meiosis I;GO:0007283 spermatogenesis;GO:1990918 double-strand break repair involved in meiotic recombination;GO:0007141 male meiosis I", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9D4G2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C673-1", "uniprot_id": [ { "id": "IGS11_MOUSE", "url": "https://www.uniprot.org/uniprot/P0C673", "type": "external" } ], "mass": 46067.0, "length": 428, "protein_name": "Immunoglobulin superfamily member 11", "gene_name": "Igsf11", "organism": "Mouse", "refseq_name": "immunoglobulin superfamily member 11 precursor", "refseq_ac": [ { "id": "NP_733548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_733548", "type": "external" } ], "gene_names_uniprotkb": "Igsf11", "gene_names_refseq": "1700025L02Rik; BT-IgSF; Igsf11; Igsf13", "protein_names_uniprotkb": "Immunoglobulin superfamily member 11; Brain and testis-specific immunoglobulin superfamily protein; Bt-IGSF; IgSF11", "protein_names_refseq": "brain and testis-specific immunoglobulin superfamily protein; immunoglobulin superfamily member 11 precursor; immunoglobulin superfamily, member 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:207683)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12207903;21750661;22645316;24129315;36607983;38036734", "class_list": "", "function": "Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth (By similarity)., [UniProtKB]; IgSF11 deficiency alleviates osteoarthritis in mice by suppressing early subchondral bone changes., [RefSeq, PubMed]; Lack of the Ig cell adhesion molecule BT-IgSF (IgSF11) induced behavioral changes in the open maze, water maze and resident intruder test. Publication Status: Online-Only, [RefSeq, PubMed]; Molecular cloning of BT-IgSF which is preferentially expressed by brain and testis, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0014069 postsynaptic density;GO:0060076 excitatory synapse", "go_biological_process": "GO:1900273 positive regulation of long-term synaptic potentiation;GO:0048167 regulation of synaptic plasticity;GO:0061885 positive regulation of mini excitatory postsynaptic potential;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0045185 maintenance of protein location", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P0C673-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62559-1", "uniprot_id": [ { "id": "IFT52_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62559", "type": "external" } ], "mass": 48248.0, "length": 426, "protein_name": "Intraflagellar transport protein 52 homolog", "gene_name": "Ift52", "organism": "Mouse", "refseq_name": "intraflagellar transport protein 52 homolog", "refseq_ac": [ { "id": "NP_742162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742162", "type": "external" } ], "gene_names_uniprotkb": "Ift52; Ngd5", "gene_names_refseq": "Ift52; NGD5", "protein_names_uniprotkb": "Intraflagellar transport protein 52 homolog; Protein NGD5", "protein_names_refseq": "intraflagellar transport 52 homolog; intraflagellar transport protein 52 homolog", "tax_id": 10090, "disease": "asphyxiating thoracic dystrophy (Disease Ontology:DOID:0050592)", "pathway": " (mmu:245866); (R-MMU-5610787); (R-MMU-5620924)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "19253336;21750661;23810713;25428506;25605945;25860617;30084848;31637240;34428180;35839863;7494458", "class_list": "", "function": "Involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia (PubMed:19253336). Required for the anterograde transport of IFT88 (By similarity)., [UniProtKB, UniProtKB, PubMed]; The intraflagellar transport protein IFT52 associated with short-rib thoracic dysplasia is essential for ciliary function in osteogenic differentiation in vitro and for sensory perception in Drosophila., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TK21;Q8BTX3;Q8CI16", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0097733 photoreceptor cell cilium;GO:0005813 centrosome;GO:0005929 cilium;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0050680 negative regulation of epithelial cell proliferation;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0001947 heart looping;GO:0009953 dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q62559-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63242-1", "uniprot_id": [ { "id": "IF5A1_MOUSE", "url": "https://www.uniprot.org/uniprot/P63242", "type": "external" } ], "mass": 16832.0, "length": 154, "protein_name": "Eukaryotic translation initiation factor 5A-1", "gene_name": "Eif5a", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 5A-1", "refseq_ac": [ { "id": "NP_001160061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160061", "type": "external" } ], "gene_names_uniprotkb": "Eif5a", "gene_names_refseq": "D19Wsu54e; Eif4d; Eif5a1; Eif5a; eIF-4D; eIF-5A-1; eIF-5A1; eIF-5A", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 5A-1; Eukaryotic initiation factor 5A isoform 1; eIF-4D; eIF-5A-1; eIF-5A1; eIF-5A", "protein_names_refseq": "eukaryotic translation initiation factor 5A-1", "tax_id": 10090, "disease": "pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); pulmonary hypertension (Disease Ontology:DOID:6432); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:276770); (R-MMU-204626)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "11161802;15377278;17707773;21540332;21750661;22645316;23806337;25153642;26495903;28528544;34428180;35984892;36288343;37333770;37453647;37507081;37653021;37743008;39927985", "class_list": "", "function": "A decrease in either active eIF5A or polyamines inhibits cell growth, indicating that eIF5A and polyamines are independently involved in cell growth, [RefSeq, PubMed]; Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Eukaryotic initiation factor 5A (eIF5A) (eIF-4D, eIF-5A) stimulates ribosomal peptidyltransferase activity, transport of HIV-1-mRNAs and binds exportins 1 and 4. Contains hypusine at lys 50. Mouse EIF5A1 and EIF5A2 encode two isoforms: eIF5AI and eIF5AII., [RefSeq, PubMed]; Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia., [RefSeq, PubMed]; Targeted inhibition of eIF5A[hpu] suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes an elongation initiation factor, which participates in protein synthesis. The encoded protein also plays roles in mRNA metabolism, cell proliferation, and cell cycle control. This protein contains a modified lysine residue called hypusine, which appears to be necessary for its function. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2, 5, and 19. [provided by RefSeq, Oct 2009]., [RefSeq]; Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P10159;Q16182;Q5NCX0;Q78NR3;Q9D0G2", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003746 translation elongation factor activity;GO:0043022 ribosome binding;GO:0017070 U6 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051149 positive regulation of muscle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P63242-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08900-1", "uniprot_id": [ { "id": "IKZF3_MOUSE", "url": "https://www.uniprot.org/uniprot/O08900", "type": "external" } ], "mass": 57967.0, "length": 507, "protein_name": "Zinc finger protein Aiolos", "gene_name": "Ikzf3", "organism": "Mouse", "refseq_name": "zinc finger protein Aiolos", "refseq_ac": [ { "id": "NP_035901", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035901", "type": "external" } ], "gene_names_uniprotkb": "Ikzf3; Zfpn1a3; Znfn1a3", "gene_names_refseq": "5830411O07Rik; Aiolos; Ikzf3; Zfpn1a3; Znfn1a3", "protein_names_uniprotkb": "Zinc finger protein Aiolos; Ikaros family zinc finger protein 3", "protein_names_refseq": "ikaros family zinc finger protein 3; zinc finger protein Aiolos; zinc finger protein, subfamily 1A, 3 (Aiolos)", "tax_id": 10090, "disease": "small cell carcinoma (Disease Ontology:DOID:0050685); immunodeficiency 84 (Disease Ontology:DOID:0061054); childhood-onset asthma (Disease Ontology:DOID:0080815); atherosclerosis (Disease Ontology:DOID:1936); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:22780); (R-MMU-9940951)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21183079;30084848;34155405;38363226;38489359;9155026;9806640", "class_list": "", "function": "Cytotoxic Programming of CD4+ T Cells Is Regulated by Opposing Actions of the Related Transcription Factors Eos and Aiolos., [RefSeq, PubMed]; Kidins220 and Aiolos promote thymic iNKT cell development by reducing TCR signals., [RefSeq, PubMed]; Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Binds to GGGAA. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9536, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B1AQE6", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0045577 regulation of B cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O08900-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01592-1", "uniprot_id": [ { "id": "IGJ_MOUSE", "url": "https://www.uniprot.org/uniprot/P01592", "type": "external" } ], "mass": 18014.0, "length": 159, "protein_name": "Immunoglobulin J chain", "gene_name": "Jchain", "organism": "Mouse", "refseq_name": "immunoglobulin J chain precursor", "refseq_ac": [ { "id": "NP_690052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690052", "type": "external" } ], "gene_names_uniprotkb": "Jchain; Igj", "gene_names_refseq": "9530090F24Rik; Igj; Jchain; Jch", "protein_names_uniprotkb": "Immunoglobulin J chain", "protein_names_refseq": "immunoglobulin J chain precursor; immunoglobulin J chain; immunoglobulin joining gene (not J region)", "tax_id": 10090, "disease": "", "pathway": " (mmu:16069); (R-MMU-202733); (R-MMU-2168880)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;1517233;20571061;3079912;34428180;36288343;6815655", "class_list": "", "function": "Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers. It also helps to bind these immunoglobulins to secretory component., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0042834 peptidoglycan binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042803 protein homodimerization activity;GO:0031210 phosphatidylcholine binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0071748 monomeric IgA immunoglobulin complex;GO:0071751 secretory IgA immunoglobulin complex;GO:0071752 secretory dimeric IgA immunoglobulin complex;GO:0071750 dimeric IgA immunoglobulin complex", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0002250 adaptive immune response;GO:0006959 humoral immune response;GO:0003094 glomerular filtration", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P01592-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C5L6-1", "uniprot_id": [ { "id": "INP5K_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C5L6", "type": "external" } ], "mass": 54159.0, "length": 468, "protein_name": "Inositol polyphosphate 5-phosphatase K", "gene_name": "Inpp5k", "organism": "Mouse", "refseq_name": "inositol polyphosphate 5-phosphatase K", "refseq_ac": [ { "id": "NP_032942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032942", "type": "external" } ], "gene_names_uniprotkb": "Inpp5k; Pps; Skip", "gene_names_refseq": "C62; Inpp5k; Pps; SKIP", "protein_names_uniprotkb": "Inositol polyphosphate 5-phosphatase K; 3.1.3.36; 3.1.3.56; 3.1.3.86; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; Phosphatidylinositol-4,5-bisphosphate 5-phosphatase; Skeletal muscle and kidney-enriched inositol phosphatase", "protein_names_refseq": "PI-5-phosphatase related; inositol polyphosphate 5-phosphatase K; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; phosphatidylinositol-4,5-bisphosphate 5-phosphatase; putative PI-5-phosphatase; skeletal muscle and kidney enriched inositol polyphosphate phosphatase; skeletal muscle and kidney-enriched inositol phosphatase", "tax_id": 10090, "disease": "muscular dystrophy-dystroglycanopathy type B1 (Disease Ontology:DOID:0050588); congenital muscular dystrophy with cataracts and intellectual disability (Disease Ontology:DOID:0080197)", "pathway": " (mmu:19062); (R-MMU-1660499)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21750661;22247557;22751929;25428506;28190456;34428180;35135857;9182797", "class_list": "", "function": "Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate (By similarity). Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle (PubMed:22247557, PubMed:22751929)., [UniProtKB, UniProtKB, PubMed, PubMed]; Inositol Polyphosphate-5-Phosphatase K (Inpp5k) Enhances Sprouting of Corticospinal Tract Axons after CNS Trauma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09040", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" } ], "go_molecular_function": "GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity;GO:0005000 vasopressin receptor activity;GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity;GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0010829 negative regulation of D-glucose transmembrane transport;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0001701 in utero embryonic development;GO:0007186 G protein-coupled receptor signaling pathway;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8C5L6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DTX6-1", "uniprot_id": [ { "id": "JCAD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5DTX6", "type": "external" } ], "mass": 144798.0, "length": 1320, "protein_name": "Junctional cadherin 5-associated protein", "gene_name": "Jcad", "organism": "Mouse", "refseq_name": "junctional cadherin 5-associated protein", "refseq_ac": [ { "id": "NP_001075432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075432", "type": "external" } ], "gene_names_uniprotkb": "Jcad; Gm328; Kiaa1462", "gene_names_refseq": "1110056P05Rik; 9430020K01Rik; Gm328; Jcad; mKIAA1462", "protein_names_uniprotkb": "Junctional cadherin 5-associated protein; JCAD; Junctional protein associated with coronary artery disease", "protein_names_refseq": "junctional cadherin 5-associated protein; junctional protein associated with coronary artery disease", "tax_id": 10090, "disease": "", "pathway": " (mmu:240185)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "17242355;21183079;21884682;25428506;28705794;30084848;31584065;34428180;34887587;36469488;38190829;38509842;39273437;40885482", "class_list": "", "function": "A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction., [RefSeq, PubMed]; JCAD deficiency attenuates activation of hepatic stellate cells and cholestatic fibrosis., [RefSeq, PubMed]; JCAD deficiency delayed liver regenerative repair through the Hippo-YAP signalling pathway., [RefSeq, PubMed]; JCAD has a redundant functional role in physiological angiogenesis but serves a pivotal role in pathological angiogenic process after birth., [RefSeq, PubMed]; JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study. Erratum:[Eur Heart J. 2023 May 21;44(20):1843. doi: 10.1093/eurheartj/ehad174. PMID: 37171028], [RefSeq, PubMed]; Loss of JCAD/KIAA1462 Protects the Lung from Acute and Chronic Consequences of Chronic Obstructive Pulmonary Disease. Publication Status: Online-Only, [RefSeq, PubMed]; These results indicate that JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. This study also suggests the implication of endothelial cell-cell adhesion in coronary artery disease., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0030054 cell junction;GO:0048471 perinuclear region of cytoplasm;GO:0032587 ruffle membrane", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0007155 cell adhesion;GO:0043410 positive regulation of MAPK cascade;GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis;GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q5DTX6-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70361-1", "uniprot_id": [ { "id": "PER3_MOUSE", "url": "https://www.uniprot.org/uniprot/O70361", "type": "external" } ], "mass": 120911.0, "length": 1113, "protein_name": "Period circadian protein homolog 3", "gene_name": "Per3", "organism": "Mouse", "refseq_name": "period circadian protein homolog 3 isoform 2", "refseq_ac": [ { "id": "NP_035197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035197", "type": "external" } ], "gene_names_uniprotkb": "Per3", "gene_names_refseq": "2810049O06Rik; Per3; mPer3", "protein_names_uniprotkb": "Period circadian protein homolog 3; Circadian clock protein PERIOD 3; mPER3", "protein_names_refseq": "circadian clock protein PERIOD 3; period circadian protein homolog 3 isoform 2; period circadian protein homolog 3; period homolog 3", "tax_id": 10090, "disease": "advanced sleep phase syndrome (Disease Ontology:DOID:0050628); advanced sleep phase syndrome 3 (Disease Ontology:DOID:0110013); alcohol use disorder (Disease Ontology:DOID:1574); bipolar disorder (Disease Ontology:DOID:3312)", "pathway": " (mmu:18628); (R-MMU-9932298)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10428031;11395012;11591712;11865049;14564007;14701732;15917222;21750661;21957163;22331899;23303907;23916625;26903630;37964605;9655499", "class_list": "", "function": "Clock gene Per3 deficiency disrupts circadian alterations of gut microbiota in mice., [RefSeq, PubMed]; Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme., [UniProtKB, PubMed, PubMed, PubMed]; This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A894", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0019900 kinase binding;GO:0000976 transcription cis-regulatory region binding;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0045187 regulation of circadian sleep/wake cycle, sleep;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0050821 protein stabilization;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O70361-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88689-1", "uniprot_id": [ { "id": "PCDA4_MOUSE", "url": "https://www.uniprot.org/uniprot/O88689", "type": "external" } ], "mass": 103143.0, "length": 947, "protein_name": "Protocadherin alpha-4", "gene_name": "Pcdha4", "organism": "Mouse", "refseq_name": "protocadherin alpha 4-gamma precursor", "refseq_ac": [ { "id": "NP_001167625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001167625", "type": "external" } ], "gene_names_uniprotkb": "Pcdha4; Cnr1", "gene_names_refseq": "Cnr1; Gm37013; Pcdha4-g; Pcdha4b; Pcdha4", "protein_names_uniprotkb": "Protocadherin alpha-4; PCDH-alpha-4", "protein_names_refseq": "PCDH-alpha-4; Protocadherin alpha-4; protocadherin alpha 4-gamma precursor; protocadherin alpha 4-gamma", "tax_id": 10090, "disease": "", "pathway": " (mmu:100384868); (mmu:12936)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;11230163;12154121;15929006;27161523;9655502", "class_list": "", "function": "Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination (Probable). Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain (PubMed:27161523)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 3, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3UEX3;Q6PAM9;Q8K487;Q8K489", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:0007155 cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O88689-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91Y13-1", "uniprot_id": [ { "id": "PCDA7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91Y13", "type": "external" } ], "mass": 101266.0, "length": 937, "protein_name": "Protocadherin alpha-7", "gene_name": "Pcdha7", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pcdha7", "gene_names_refseq": "", "protein_names_uniprotkb": "Protocadherin alpha-7; PCDH-alpha-7", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:12939)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;11230163;27161523", "class_list": "", "function": "Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination (PubMed:27161523). Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain (PubMed:27161523)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 4, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0009988 cell-cell recognition", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q91Y13-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2U1-1", "uniprot_id": [ { "id": "PSA5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2U1", "type": "external" } ], "mass": 26411.0, "length": 241, "protein_name": "Proteasome subunit alpha type-5", "gene_name": "Psma5", "organism": "Mouse", "refseq_name": "proteasome subunit alpha type-5", "refseq_ac": [ { "id": "NP_036097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036097", "type": "external" } ], "gene_names_uniprotkb": "Psma5", "gene_names_refseq": "Psma5; ZETA", "protein_names_uniprotkb": "Proteasome subunit alpha type-5; Macropain zeta chain; Multicatalytic endopeptidase complex zeta chain; Proteasome subunit alpha-5; Proteasome zeta chain; alpha-5", "protein_names_refseq": "alpha-5; macropain zeta chain; multicatalytic endopeptidase complex zeta chain; proteasome (prosome, macropain) subunit, alpha type 5; proteasome subunit alpha type-5; proteasome zeta chain", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:26442); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236974); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-6798695); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9912633); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 59, "publication_count": 14, "publication_id_list": "10436176;16581775;16857966;20173027;21750661;22341445;22556278;25428506;26495903;26740625;30779550;34203471;34428180;37828378", "class_list": "", "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000502 proteasome complex", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process;GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9Z2U1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35282-1", "uniprot_id": [ { "id": "RAB21_MOUSE", "url": "https://www.uniprot.org/uniprot/P35282", "type": "external" } ], "mass": 24106.0, "length": 222, "protein_name": "Ras-related protein Rab-21", "gene_name": "Rab21", "organism": "Mouse", "refseq_name": "ras-related protein Rab-21", "refseq_ac": [ { "id": "NP_077774", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077774", "type": "external" } ], "gene_names_uniprotkb": "Rab21", "gene_names_refseq": "9630024B22; Rab21", "protein_names_uniprotkb": "Ras-related protein Rab-21; 3.6.5.2; Rab-12", "protein_names_refseq": "rab-12; ras-related protein Rab-21", "tax_id": 10090, "disease": "", "pathway": " (mmu:216344); (R-MMU-8873719); (R-MMU-8876198)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;1555775;16754960;18804435;19745841;21750661;26495903;26740625;30084848;30471852;30779550;31402118;33300544;34428180;35163051;37507081;37828378", "class_list": "", "function": "Rab21 Protein Is Degraded by Both the Ubiquitin-Proteasome Pathway and the Autophagy-Lysosome Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Rab21 mediates caerulin-induced MKK3-p38 activation and pro-inflammatory responses., [RefSeq, PubMed]; Rab21 regulates LPS-induced pro-inflammatory responses by promoting TLR4 endosomal traffic and downstream signaling activation, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:16754960, PubMed:18804435). RAB21 is involved in membrane trafficking control (PubMed:16754960, PubMed:18804435). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (PubMed:16754960). As a result, may regulate cell adhesion and migration (PubMed:16754960). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (By similarity). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPN7", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005769 early endosome;GO:0045202 synapse;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0050821 protein stabilization;GO:0030516 regulation of axon extension;GO:0008089 anterograde axonal transport;GO:0050775 positive regulation of dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P35282-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LL5-1", "uniprot_id": [ { "id": "PWP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LL5", "type": "external" } ], "mass": 55587.0, "length": 501, "protein_name": "Periodic tryptophan protein 1 homolog", "gene_name": "Pwp1", "organism": "Mouse", "refseq_name": "periodic tryptophan protein 1 homolog", "refseq_ac": [ { "id": "NP_598754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598754", "type": "external" } ], "gene_names_uniprotkb": "Pwp1", "gene_names_refseq": "2310058A11Rik; 2610205J09Rik; Pwp1", "protein_names_uniprotkb": "Periodic tryptophan protein 1 homolog", "protein_names_refseq": "periodic tryptophan protein 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:103136)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15345747;17242355;19144319;21183079;21750661;25335925;25428506;34428180", "class_list": "", "function": "Authors found that the level of Pwp1 in mESCs is much higher than that in mouse embryonic fibroblasts (MEFs) and Pwp1 KD critically affects the conversion of mESCs from pluripotency to differentiation., [RefSeq, PubMed]; Chromatin-associated factor that regulates transcription (By similarity). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (By similarity). Regulates the epigenetic status of rDNA (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D6T6", "ec_number_list": [], "go_molecular_function": "GO:1990889 histone H4K20me3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005794 Golgi apparatus;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0006364 rRNA processing;GO:2000738 positive regulation of stem cell differentiation;GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99LL5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZE3-1", "uniprot_id": [ { "id": "RAB32_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZE3", "type": "external" } ], "mass": 25068.0, "length": 223, "protein_name": "Ras-related protein Rab-32", "gene_name": "Rab32", "organism": "Mouse", "refseq_name": "ras-related protein Rab-32", "refseq_ac": [ { "id": "NP_080681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080681", "type": "external" } ], "gene_names_uniprotkb": "Rab32", "gene_names_refseq": "2810011A17Rik; Rab32", "protein_names_uniprotkb": "Ras-related protein Rab-32; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-32", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:67844); (R-MMU-8873719); (R-MMU-8876198)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "14499590;19403694;21187289;21750661;26620560;33392103;36430618;37793839", "class_list": "", "function": "Data report the cloning and characterization of the mouse homologue of human Rab32., [RefSeq, PubMed]; Rab32 and Rab38 maintain bone homeostasis by regulating intracellular traffic in osteoclasts., [RefSeq, PubMed]; Rab32/38-Dependent and -Independent Transport of Tyrosinase to Melanosomes in B16-F1 Melanoma Cells. Publication Status: Online-Only, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Also acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays an important role in the control of melanin production and melanosome biogenesis (By similarity). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (PubMed:26620560). Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2 (By similarity)., [UniProtKB, UniProtKB, PubMed]; VARP and Rab9 Are Dispensable for the Rab32/BLOC-3 Dependent Salmonella Killing. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TXU7;Q8BVD3;Q91YN4", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0035651 AP-3 adaptor complex binding;GO:0036461 BLOC-2 complex binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:1903232 melanosome assembly;GO:0090382 phagosome maturation;GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0032438 melanosome organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CZE3-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AUH1-1", "uniprot_id": [ { "id": "PTPRU_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AUH1", "type": "external" } ], "mass": 162494.0, "length": 1446, "protein_name": "Receptor-type tyrosine-protein phosphatase U", "gene_name": "Ptpru", "organism": "Mouse", "refseq_name": "receptor-type tyrosine-protein phosphatase U isoform 2 precursor", "refseq_ac": [ { "id": "NP_001076588", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076588", "type": "external" } ], "gene_names_uniprotkb": "Ptpru; Pcp2; Ptpf", "gene_names_refseq": "Ftp-1; PCP-2; PTP-lambda; PTPlambda; PTP; Pcp2; Ptpf; Ptprl; Ptpru; R-PTP-U; R-PTP-psi; RPTPlambda", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase U; 3.1.3.48; Ftp-1; PCP-2; PTP-lambda; PTPlambda; Pancreatic carcinoma phosphatase 2; Protein-tyrosine phosphatase-lamda; R-PTP-U; R-PTP-psi; Receptor-type protein-tyrosine phosphatase psi", "protein_names_refseq": "Pancreatic carcinoma phosphatase 2; Protein-tyrosine phosphatase-lamda; Receptor-type protein-tyrosine phosphatase psi; Receptor-type tyrosine-protein phosphatase U; protein tyrosine phosphatase, receptor type, L; receptor-type tyrosine-protein phosphatase U isoform 2 precursor", "tax_id": 10090, "disease": "membranous glomerulonephritis (Disease Ontology:DOID:10976); nephrosis (Disease Ontology:DOID:2527)", "pathway": " (mmu:19273); (R-MMU-1433557)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;15040814;21183079;30084848;30899004;9054423;9272866", "class_list": "", "function": "Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 8, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "O35564;P70125;Q3V312;Q66JV9", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008013 beta-catenin binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0034109 homotypic cell-cell adhesion;GO:0007165 signal transduction;GO:0008285 negative regulation of cell population proliferation;GO:0031175 neuron projection development;GO:0090090 negative regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "B1AUH1-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RU40-1", "uniprot_id": [ { "id": "PRRT4_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RU40", "type": "external" } ], "mass": 93979.0, "length": 902, "protein_name": "Proline-rich transmembrane protein 4", "gene_name": "Prrt4", "organism": "Mouse", "refseq_name": "proline-rich transmembrane protein 4 precursor", "refseq_ac": [ { "id": "NP_001094913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094913", "type": "external" } ], "gene_names_uniprotkb": "Prrt4", "gene_names_refseq": "D330027H18Rik; Prrt4", "protein_names_uniprotkb": "Proline-rich transmembrane protein 4", "protein_names_refseq": "proline-rich transmembrane protein 4 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:101359)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QKZ9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2RU40-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CG50-1", "uniprot_id": [ { "id": "RAB43_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CG50", "type": "external" } ], "mass": 23263.0, "length": 210, "protein_name": "Ras-related protein Rab-43", "gene_name": "Rab43", "organism": "Mouse", "refseq_name": "ras-related protein Rab-43 isoform a", "refseq_ac": [ { "id": "NP_001034483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034483", "type": "external" } ], "gene_names_uniprotkb": "Rab43", "gene_names_refseq": "1810048P08Rik; 2500004H21Rik; Rab43", "protein_names_uniprotkb": "Ras-related protein Rab-43; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-43 isoform a; ras-related protein Rab-43", "tax_id": 10090, "disease": "", "pathway": " (mmu:69834); (R-MMU-6811440); (R-MMU-8873719)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "19144319;21750661;27899443;29125462;35392093", "class_list": "", "function": "Extracellular HMGB1 Impairs Macrophage-Mediated Efferocytosis by Suppressing the Rab43-Controlled Cell Surface Transport of CD91. Publication Status: Online-Only, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Required for the structural integrity of the Golgi complex. Also controls the anterograde ER-to-Golgi transport of nascent G protein-coupled receptors (including ADRA2A, ADRA2B, ADRA2C, ADRA1B, ADRB2 and AGTR1) and regulates the ER sorting of GPCR members by virtue of its ability to interact directly. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis., [UniProtKB, UniProtKB]; These results suggest that RAB43 provides a specialized activity used in cross-presentation selectively by CD8alpha(+) DCs but not other antigen-presenting cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:0090382 phagosome maturation;GO:0000045 autophagosome assembly;GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0071346 cellular response to type II interferon", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CG50-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60790-1", "uniprot_id": [ { "id": "RASA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60790", "type": "external" } ], "mass": 95987.0, "length": 834, "protein_name": "Ras GTPase-activating protein 3", "gene_name": "Rasa3", "organism": "Mouse", "refseq_name": "ras GTPase-activating protein 3", "refseq_ac": [ { "id": "NP_033051", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033051", "type": "external" } ], "gene_names_uniprotkb": "Rasa3", "gene_names_refseq": "E130011G04; GAPIII; Rasa3; hlb381; scat", "protein_names_uniprotkb": "Ras GTPase-activating protein 3; GAP1(IP4BP); GapIII; Ins P4-binding protein", "protein_names_refseq": "GAP1(IP4BP); GAPIII activator 3; R-Ras gap; R-ras RTPase activating protein-3; Ras GTPase-activating protein III; ins P4-binding protein; ras GTPase-activating protein 3", "tax_id": 10090, "disease": "aplastic anemia (Disease Ontology:DOID:12449)", "pathway": " (mmu:19414); (R-MMU-5658442)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "17947660;19144319;21183079;21750661;25428506;29187734;30084848;31219806;31599954;32782141;33370780;34203471;34428180;36210013;7500386", "class_list": "", "function": "Differential effects of RASA3 mutations on hematopoiesis are profoundly influenced by genetic background and molecular variant. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibitory regulator of the Ras-cyclic AMP pathway. May bind inositol tetrakisphosphate (IP4)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PG24;Q925V1", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0035556 intracellular signal transduction;GO:0034605 cellular response to heat;GO:0030168 platelet activation;GO:1902531 regulation of intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q60790-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QUM9-1", "uniprot_id": [ { "id": "PSA6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QUM9", "type": "external" } ], "mass": 27372.0, "length": 246, "protein_name": "Proteasome subunit alpha type-6", "gene_name": "Psma6", "organism": "Mouse", "refseq_name": "proteasome subunit alpha type-6 isoform 1", "refseq_ac": [ { "id": "NP_036098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036098", "type": "external" } ], "gene_names_uniprotkb": "Psma6", "gene_names_refseq": "IOTA; Psma6", "protein_names_uniprotkb": "Proteasome subunit alpha type-6; Macropain iota chain; Multicatalytic endopeptidase complex iota chain; Proteasome iota chain; Proteasome subunit alpha-1; alpha-1", "protein_names_refseq": "alpha-1; macropain iota chain; multicatalytic endopeptidase complex iota chain; proteasome (prosome, macropain) subunit, alpha type 6; proteasome iota chain; proteasome subunit alpha type-6 isoform 1; proteasome subunit alpha type-6; proteasome subunit alpha-1", "tax_id": 10090, "disease": "myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:26443); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236974); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9912633); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 58, "publication_count": 17, "publication_id_list": "10436176;16317774;16581775;16857966;18034455;21420386;21750661;22078707;22341445;22556278;23386199;23806337;26740625;32069316;34428180;37453647;37507081", "class_list": "", "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; In this study a novel interaction between calcineurin and the 20S proteasome subunit PSMA6 that increased intracellular proteasomal activity was identified., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0VGS3;Q3TT07;Q3U6Y2", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0051059 NF-kappaB binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050727 regulation of inflammatory response;GO:0010498 proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9QUM9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61226-1", "uniprot_id": [ { "id": "RAP2B_MOUSE", "url": "https://www.uniprot.org/uniprot/P61226", "type": "external" } ], "mass": 20504.0, "length": 183, "protein_name": "Ras-related protein Rap-2b", "gene_name": "Rap2b", "organism": "Mouse", "refseq_name": "ras-related protein Rap-2b", "refseq_ac": [ { "id": "NP_082988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082988", "type": "external" } ], "gene_names_uniprotkb": "Rap2b", "gene_names_refseq": "4021402C18Rik; Rap2b", "protein_names_uniprotkb": "Ras-related protein Rap-2b; 3.6.5.2", "protein_names_refseq": "ras-related protein Rap-2b", "tax_id": 10090, "disease": "", "pathway": " (mmu:74012); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16928684;19061864;25428506;26201295;30084848;30779550;33300544;9523700", "class_list": "", "function": "Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells., [UniProtKB, PubMed]; Taken together, these findings shed light on Rap2B as a therapeutic target for breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; The putative Rap2 binding site of the RPIPx RUN domain interacts with the extended segment in a segment-swapping manner, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P17964;Q96EG5;Q9CXG0", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.3.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.78", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019904 protein domain specific binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016020 membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0032486 Rap protein signal transduction;GO:0030336 negative regulation of cell migration;GO:0030168 platelet activation;GO:0070527 platelet aggregation;GO:0031954 positive regulation of protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P61226-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q14B62-1", "uniprot_id": [ { "id": "PTHD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q14B62", "type": "external" } ], "mass": 101506.0, "length": 888, "protein_name": "Patched domain-containing protein 1", "gene_name": "Ptchd1; ptchd1", "organism": "Mouse", "refseq_name": "patched domain-containing protein 1", "refseq_ac": [ { "id": "NP_001087219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001087219", "type": "external" } ], "gene_names_uniprotkb": "Ptchd1; ptchd1", "gene_names_refseq": "9630036J22Rik; Gm387; Ptchd1", "protein_names_uniprotkb": "Patched domain-containing protein 1", "protein_names_refseq": "patched domain-containing protein 1", "tax_id": 10090, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (mmu:211612)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;20844286;21750661;27007844;28416808;29118110;30899004;37990104;38275824", "class_list": "", "function": "Neuronal transcription of autism gene PTCHD1 is regulated by a conserved downstream enhancer sequence. Publication Status: Online-Only, [RefSeq, PubMed]; Required for the development and function of the thalamic reticular nucleus (TRN), a part of the thalamus that is critical for thalamocortical transmission, generation of sleep rhythms, sensorimotor processing and attention. Can bind cholesterol in vitro (By similarity)., [UniProtKB, PubMed, UniProtKB]; Results support that PTCHD1 deficiency induces a neurodevelopmental disorder causing excitatory synaptic dysfunction., [RefSeq, PubMed]; Thalamic reticular nucleus-restricted deletion of Ptchd1 leads to attention deficits and hyperactivity, both of which are rescued by pharmacological augmentation of small conductance calcium-dependent potassium channel activity, [RefSeq, PubMed]; The Ptchd1 protein plays a critical role in the dentate gyrus and is associated with dendritic trafficking., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 2, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "B1AZU9;Q14B63;Q8BZA5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0045202 synapse", "go_biological_process": "GO:0050890 cognition;GO:0007268 chemical synaptic transmission;GO:0035176 social behavior;GO:0007224 smoothened signaling pathway;GO:0021794 thalamus development", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q14B62-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQD1-1", "uniprot_id": [ { "id": "RAB5A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQD1", "type": "external" } ], "mass": 23599.0, "length": 215, "protein_name": "Ras-related protein Rab-5A", "gene_name": "Rab5a", "organism": "Mouse", "refseq_name": "ras-related protein Rab-5A", "refseq_ac": [ { "id": "NP_080163", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080163", "type": "external" } ], "gene_names_uniprotkb": "Rab5a; nnyRab5a", "gene_names_refseq": "2410015H04Rik; Rab5a; nnyRab5a", "protein_names_uniprotkb": "Ras-related protein Rab-5A; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-5A", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:271457); (R-MMU-1660499); (R-MMU-8856828); (R-MMU-8873719); (R-MMU-8876198); (R-MMU-983231)", "pathway_count": 6, "publication_count": 18, "publication_id_list": "11773082;16923123;17322886;17509819;18425118;21059846;22872234;25428506;25568335;25869668;26740625;30084848;32051546;33300544;34428180;35820727;37828378;38485453", "class_list": "", "function": "Internalisation of neutrophils extracellular traps by macrophages aggravate rheumatoid arthritis via Rab5a. Publication Status: Online-Only, [RefSeq, PubMed]; Rab5a activates IRS1 to coordinate IGF-AKT-mTOR signaling and myoblast differentiation during muscle regeneration., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes and involved in early endocytic trafficking (PubMed:18425118). Required for EEA1 recruitment to early endosomes. Recruits FERRY complex to early endosomes, where FERRY links early endosomes with a subgroup of mRNAs to enable mRNA intracellular distribution (By similarity). Recruits RABEP1/Rabaptin-5 effector to early endosomes, thereby promoting endocytic membrane fusion (By similarity). Required for EGF and transferrin endocytosis and trafficking through early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (By similarity). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity) (PubMed:18425118)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UCX7;Q4VAA1;Q9DCN5", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0051021 GDP-dissociation inhibitor binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098844 postsynaptic endocytic zone membrane;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0031623 receptor internalization;GO:0048169 regulation of long-term neuronal synaptic plasticity;GO:0006909 phagocytosis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9CQD1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K411-1", "uniprot_id": [ { "id": "PREP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K411", "type": "external" } ], "mass": 117372.0, "length": 1036, "protein_name": "Presequence protease, mitochondrial", "gene_name": "Pitrm1", "organism": "Mouse", "refseq_name": "presequence protease, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_660113", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660113", "type": "external" } ], "gene_names_uniprotkb": "Pitrm1; Kiaa1104; Ntup1", "gene_names_refseq": "2310012C15Rik; MP-1; MP1; Ntup1; Pitrm1; PreP; mKIAA1104", "protein_names_uniprotkb": "Presequence protease, mitochondrial; 3.4.24.-; Pitrilysin metalloproteinase 1", "protein_names_refseq": "nuclear transplantation upregulated protein 1; pitrilysin metalloprotease 1; pitrilysin metalloproteinase 1; presequence protease, mitochondrial isoform 1 precursor; presequence protease, mitochondrial", "tax_id": 10090, "disease": "hereditary ataxia (Disease Ontology:DOID:0050951); autosomal recessive spinocerebellar ataxia 30 (Disease Ontology:DOID:0070411); Alzheimer's disease (Disease Ontology:DOID:10652); primary cerebellar degeneration (Disease Ontology:DOID:9277)", "pathway": " (mmu:69617); (R-MMU-1268020)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12490196;15919810;19877269;21750661;22645316;23576753;23806337;25428506;25605945;30084848", "class_list": "", "function": "Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides. It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion. It is a highly efficient protease, at least toward amyloid-beta protein 40. Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently. It is also able to degrade amyloid-beta protein 42., [UniProtKB, UniProtKB]; Pitrm1 is expressed in Pax3-expressing myoblast progenitors in the limb, the dermomyotome, and developing muscles of the face and torso., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3THC4;Q3TJI1;Q3TPP0;Q3URQ8;Q4KUG2;Q4KUG3;Q6ZPX6;Q922N1;Q9CV63", "ec_number_list": [ { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.1.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.3.3", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "2.5.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.39", "type": "external" }, { "id": "1.1.98.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.98.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8K411-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64737-1", "uniprot_id": [ { "id": "PUR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64737", "type": "external" } ], "mass": 107503.0, "length": 1010, "protein_name": "Trifunctional purine biosynthetic protein adenosine-3", "gene_name": "Gart", "organism": "Mouse", "refseq_name": "trifunctional purine biosynthetic protein adenosine-3", "refseq_ac": [ { "id": "NP_034386", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034386", "type": "external" } ], "gene_names_uniprotkb": "Gart", "gene_names_refseq": "Gaps; Gart; Prgs", "protein_names_uniprotkb": "Trifunctional purine biosynthetic protein adenosine-3; 5'-phosphoribosylglycinamide transformylase; AIR synthase; AIRS; GAR transformylase; GARS; GART; Glycinamide ribonucleotide synthetase; Phosphoribosyl-aminoimidazole synthetase; Phosphoribosylglycinamide synthetase", "protein_names_refseq": "glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide formyltransferase; glycinamide ribonucleotide synthetase; trifunctional purine biosynthetic protein adenosine-3", "tax_id": 10090, "disease": "Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (mmu:14450); (R-MMU-73817)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "21183079;21750661;31219806;31599954;34428180;34887587;35820727;36210013;37507081;37828378;39627609;39927985;7829519;8299947", "class_list": "", "function": "Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TGI3;Q6NS48", "ec_number_list": [ { "id": "2.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.2", "type": "external" }, { "id": "6.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.3.1", "type": "external" }, { "id": "6.3.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.13", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004637 phosphoribosylamine-glycine ligase activity;GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity;GO:0004644 phosphoribosylglycinamide formyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0003360 brainstem development;GO:0021987 cerebral cortex development;GO:0021549 cerebellum development;GO:0006177 GMP biosynthetic process;GO:0006164 purine nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q64737-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAS4-1", "uniprot_id": [ { "id": "PR8A8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAS4", "type": "external" } ], "mass": 28089.0, "length": 241, "protein_name": "Prolactin-8A8", "gene_name": "Prl8a8", "organism": "Mouse", "refseq_name": "prolactin-8A8 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001298054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298054", "type": "external" } ], "gene_names_uniprotkb": "Prl8a8; Prlpc3", "gene_names_refseq": "1600032B14Rik; Ghd14; PLP-C3; PLP-Cgamma; Prl8a8; Prlpc3", "protein_names_uniprotkb": "Prolactin-8A8; PLP C-gamma; PLP-C3; PRL-like protein C3; Placental prolactin-like protein C3; Prolactin-like protein C-gamma", "protein_names_refseq": "PLP-C gamma2; PRL-like protein C3; growth hormone d14; placental prolactin-like protein C3; prolactin-8A8 isoform 1 precursor; prolactin-8A8; prolactin-like protein C-gamma", "tax_id": 10090, "disease": "", "pathway": " (mmu:74188)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12488360;21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VHE8", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DAS4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RQC6-1", "uniprot_id": [ { "id": "PYR1_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RQC6", "type": "external" } ], "mass": 243238.0, "length": 2225, "protein_name": "Multifunctional protein CAD", "gene_name": "Cad", "organism": "Mouse", "refseq_name": "multifunctional protein CAD isoform 2", "refseq_ac": [ { "id": "NP_001276451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276451", "type": "external" } ], "gene_names_uniprotkb": "Cad", "gene_names_refseq": "2410008J01Rik; Cad; Cpad", "protein_names_uniprotkb": "Multifunctional protein CAD; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase", "protein_names_refseq": "carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; multifunctional protein CAD isoform 2; multifunctional protein CAD", "tax_id": 10090, "disease": "orotic aciduria (Disease Ontology:DOID:0050833); developmental and epileptic encephalopathy 50 (Disease Ontology:DOID:0080419); rhabdomyosarcoma (Disease Ontology:DOID:3247); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); carbamoyl phosphate synthetase I deficiency disease (Disease Ontology:DOID:9280)", "pathway": " (mmu:69719); (R-MMU-500753)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;18299400;21183079;21750661;21952136;22645316;24788674;25428506;26495903;30779550;31219806;33649389;34428180;37828378;39627609", "class_list": "", "function": "Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B7ZN27", "ec_number_list": [ { "id": "6.3.4.16", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.16", "type": "external" }, { "id": "2.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.3.2", "type": "external" }, { "id": "3.5.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.3", "type": "external" }, { "id": "6.3.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.5", "type": "external" }, { "id": "3.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0004087 carbamoyl-phosphate synthase (ammonia) activity;GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity;GO:0004151 dihydroorotase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0043195 terminal bouton", "go_biological_process": "GO:0019240 citrulline biosynthetic process;GO:0001889 liver development;GO:0007507 heart development;GO:0042594 response to starvation;GO:0031000 response to caffeine", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "B2RQC6-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHS2-1", "uniprot_id": [ { "id": "CRUM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHS2", "type": "external" } ], "mass": 153350.0, "length": 1405, "protein_name": "Protein crumbs homolog 1", "gene_name": "Crb1", "organism": "Mouse", "refseq_name": "protein crumbs homolog 1 precursor", "refseq_ac": [ { "id": "NP_573502", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573502", "type": "external" } ], "gene_names_uniprotkb": "Crb1", "gene_names_refseq": "7530426H14Rik; A930008G09Rik; CRB1-A2; CRB1-A; CRB1-B; CRB1-C; Crb1", "protein_names_uniprotkb": "Protein crumbs homolog 1", "protein_names_refseq": "protein crumbs homolog 1 precursor; protein crumbs homolog 1", "tax_id": 10090, "disease": "cone-rod dystrophy (Disease Ontology:DOID:0050572); Leber congenital amaurosis 8 (Disease Ontology:DOID:0110079); retinitis pigmentosa 12 (Disease Ontology:DOID:0110358); pigmented paravenous chorioretinal atrophy (Disease Ontology:DOID:0111541); retinitis pigmentosa (Disease Ontology:DOID:10584); Leber congenital amaurosis (Disease Ontology:DOID:14791); retinal disease (Disease Ontology:DOID:5679)", "pathway": " (mmu:170788)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11744384;11850625;12915475;14684155;15316081;21750661;23001562;26404741;38412859;39198547", "class_list": "", "function": "A simple and effective PCR based method for genotyping rd1 (Pde6b) and rd8 (Crb1) in mice. Publication Status: Online-Only, [RefSeq, PubMed]; CRB1-associated retinal degeneration is dependent on bacterial translocation from the gut., [RefSeq, PubMed]; Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain., [RefSeq, PubMed]; May play a role in epidermal tissue morphogenesis (PubMed:14684155). May function in cell attachment for stratified epithelial organization (PubMed:14684155)., [UniProtKB, PubMed]; Plays a role in photoreceptor morphogenesis in the retina (PubMed:12915475). May maintain cell polarization and adhesion (PubMed:15316081)., [UniProtKB, PubMed, PubMed]; Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion., [UniProtKB, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 9, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 9768, "biomarker_type": "", "glycan_count": 3, "disease_count": 7, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "B7ZC63;Q6ST50;Q71JF2;Q8BGR4", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0007009 plasma membrane organization;GO:0001974 blood vessel remodeling;GO:0061024 membrane organization;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8VHS2-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0V8-1", "uniprot_id": [ { "id": "CINP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0V8", "type": "external" } ], "mass": 24104.0, "length": 212, "protein_name": "Cyclin-dependent kinase 2-interacting protein", "gene_name": "Cinp", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 2-interacting protein isoform 1", "refseq_ac": [ { "id": "NP_080324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080324", "type": "external" } ], "gene_names_uniprotkb": "Cinp", "gene_names_refseq": "1810047K05Rik; 2810452K22Rik; Cinp", "protein_names_uniprotkb": "Cyclin-dependent kinase 2-interacting protein", "protein_names_refseq": "cyclin-dependent kinase 2-interacting protein isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67236)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;30084848;31219806", "class_list": "", "function": "Component of the DNA replication complex, which interacts with two kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling in response to DNA damage. Part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity. As part of 55LCC complex, also involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C063;Q9D8P9", "ec_number_list": [], "go_molecular_function": "GO:1990275 preribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:1904949 ATPase complex", "go_biological_process": "GO:0006281 DNA repair;GO:0051301 cell division;GO:0042273 ribosomal large subunit biogenesis;GO:0006260 DNA replication;GO:0090069 regulation of ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D0V8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61330-1", "uniprot_id": [ { "id": "CNTN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61330", "type": "external" } ], "mass": 113217.0, "length": 1040, "protein_name": "Contactin-2", "gene_name": "Cntn2", "organism": "Mouse", "refseq_name": "contactin-2 precursor", "refseq_ac": [ { "id": "NP_796103", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796103", "type": "external" } ], "gene_names_uniprotkb": "Cntn2; Tax", "gene_names_refseq": "Cntn2; D130012K04Rik; TAG-1; TAG1; Tax", "protein_names_uniprotkb": "Contactin-2; Axonal glycoprotein TAG-1; Axonin-1; TAX-1; Transient axonal glycoprotein 1", "protein_names_refseq": "TAX-1; axonal glycoprotein TAG-1; axonin-1; axonin; contactin-2 precursor; transient axonal glycoprotein 1", "tax_id": 10090, "disease": "familial adult myoclonic epilepsy 5 (Disease Ontology:DOID:0111691); high grade glioma (Disease Ontology:DOID:3070); T-cell adult acute lymphocytic leukemia (Disease Ontology:DOID:5602); lung disease (Disease Ontology:DOID:850)", "pathway": " (mmu:21367)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;16452087;21750661;30899004;33300544", "class_list": "", "function": "In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region., [UniProtKB]; This gene encodes a member of the contactin family of proteins, part of the immunoglobulin superfamily of cell adhesion molecules. The encoded glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein plays a role in the proliferation, migration, and axon guidance of neurons of the developing cerebellum. Mice lacking a functional copy of this gene exhibit epileptic seizures and elevated expression of A1 adenosine receptors. [provided by RefSeq, Sep 2016]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 9, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 10, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 10, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 5, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 17, "disease_count": 4, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q6NZJ4;Q7TSJ5", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0098632 cell-cell adhesion mediator activity;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0043209 myelin sheath", "go_biological_process": "GO:0007409 axonogenesis;GO:0007612 learning;GO:0022010 central nervous system myelination;GO:0031175 neuron projection development;GO:0031623 receptor internalization", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q61330-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z319-1", "uniprot_id": [ { "id": "CORIN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z319", "type": "external" } ], "mass": 123006.0, "length": 1113, "protein_name": "Atrial natriuretic peptide-converting enzyme", "gene_name": "Corin", "organism": "Mouse", "refseq_name": "atrial natriuretic peptide-converting enzyme isoform 2", "refseq_ac": [ { "id": "NP_001116228", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116228", "type": "external" } ], "gene_names_uniprotkb": "Corin; Crn; Lrp4", "gene_names_refseq": "Corin; Lrp4", "protein_names_uniprotkb": "Atrial natriuretic peptide-converting enzyme; 3.4.21.-; Corin; Low density lipoprotein receptor-related protein 4; Pro-ANP-converting enzyme", "protein_names_refseq": "atrial natriuretic peptide-converting enzyme isoform 2; atrial natriuretic peptide-converting enzyme; low density lipoprotein receptor-related protein 4; low density lipoprotein-related protein 4; pro-ANP-converting enzyme", "tax_id": 10090, "disease": "familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:53419); (R-MMU-5578768)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11884416;12154094;15637153;20613715;21518754;21750661;21903139;22418978;22437503;37827215;38246101;38246520;9756624", "class_list": "", "function": "Corin deficiency alleviates mucosal lesions in a mouse model of colitis induced by dextran sulfate sodium., [RefSeq, PubMed]; Corin protects against acute kidney injury in mice through anti-inflammatory effects., [RefSeq, PubMed]; Data establish corin as the physiological pro-ANP convertase and indicate that corin deficiency may contribute to hypertensive heart disease (pro-ANP convertase corin), [RefSeq, PubMed]; Overexpression of Corin Ameliorates Kidney Fibrosis through Inhibition of Wnt/beta-Catenin Signaling in Mice., [RefSeq, PubMed]; Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes., [RefSeq, PubMed]; Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) processing (PubMed:11884416, PubMed:15637153). Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation (PubMed:11884416, PubMed:15637153, PubMed:22418978). Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus (PubMed:22437503). Also acts as a regulator of sodium reabsorption in kidney (PubMed:20613715, PubMed:22418978). May also process pro-NPPB the B-type natriuretic peptide (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These data indicate that the GATA element and its binding to GATA-4 are essential for cardiac expression of the human and murine corin genes., [RefSeq, PubMed]", "predicted_glycosites": 15, "predicted_n_glycosites": 14, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 9536, "biomarker_type": "", "glycan_count": 3, "disease_count": 4, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "B2RRC6;Q566K6", "ec_number_list": [ { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0015629 actin cytoskeleton;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide;GO:0016486 peptide hormone processing;GO:0008217 regulation of blood pressure;GO:0007565 female pregnancy;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9Z319-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80X19-1", "uniprot_id": [ { "id": "COEA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80X19", "type": "external" } ], "mass": 193013.0, "length": 1797, "protein_name": "Collagen alpha-1(XIV) chain", "gene_name": "Col14a1", "organism": "Mouse", "refseq_name": "collagen alpha-1(XIV) chain isoform 1 precursor", "refseq_ac": [ { "id": "NP_001355351", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001355351", "type": "external" } ], "gene_names_uniprotkb": "Col14a1", "gene_names_refseq": "5730412L22Rik; Col14a1", "protein_names_uniprotkb": "Collagen alpha-1(XIV) chain", "protein_names_refseq": "collagen alpha-1(XIV) chain isoform 1 precursor; collagen alpha-1(XIV) chain; procollagen, type XIV, alpha 1", "tax_id": 10090, "disease": "esophagus squamous cell carcinoma (Disease Ontology:DOID:3748)", "pathway": " (mmu:12818); (R-MMU-1650814); (R-MMU-8948216)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10393435;12853031;15065570;16129687;21750661;34428180;34560063;37453647", "class_list": "glycogene", "function": "Collagen XIV Is an Intrinsic Regulator of Corneal Stromal Structure and Function., [RefSeq, PubMed]; Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity)., [UniProtKB]; The 6456 nucleotide (nt) cDNA contains 5391-nt open reading frame encoding 1797 amino acid residues. Amino terminus has a28-residue signal peptide followed by mature polypeptide of 1769 amino acid residues with calculated molecular mass of 193.2 kDa., [RefSeq, PubMed]; The entire mouse cDNA sequence for type XIV collagen was determined using overlapping PCR products. The 6456 nucleotide (nt) cDNA sequence contains a 5391-nt open reading frame encoding 1797 amino acid residues., [RefSeq, PubMed]; The fibronectin type III domain of collagen XIV is an inducer of quiescence and differentiation in fibroblasts and preadipocytes, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 2, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 76, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVS2;Q8C6X3;Q9WV05", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005614 interstitial matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0030198 extracellular matrix organization;GO:0048873 homeostasis of number of cells within a tissue;GO:0030199 collagen fibril organization;GO:0003229 ventricular cardiac muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q80X19-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000011000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TN75-1", "uniprot_id": [ { "id": "PEG10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TN75", "type": "external" } ], "mass": 109849.0, "length": 958, "protein_name": "Retrotransposon-derived protein PEG10", "gene_name": "Peg10", "organism": "Mouse", "refseq_name": "retrotransposon-derived protein PEG10 isoform 2", "refseq_ac": [ { "id": "NP_001035701", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035701", "type": "external" } ], "gene_names_uniprotkb": "Peg10; Edr; Mar2; Mart2; Mef3l1; Rgag3", "gene_names_refseq": "Edr; HB-1; MEF3L; Mar2; Mart2; MmPEG10; MyEF-3; Peg10; Rtl2", "protein_names_uniprotkb": "Retrotransposon-derived protein PEG10; Embryonal carcinoma differentiation regulated protein; MEF3-like protein 1; Mammalian retrotransposon-derived protein 2; MmPEG10; MyEF-3; Myelin expression factor 3-like protein 1; Myelin expression factor 3; Paternally expressed gene 10 protein; Retrotransposon gag domain-containing protein 3; Retrotransposon-derived gag-like polyprotein; Ty3/Gypsy-like protein", "protein_names_refseq": "MEF3-like protein 1; MyEF-3 like; embryonal carcinoma differentiation regulated protein; mammalian retrotransposon-derived protein 2; myelin expression factor 3-like protein 1; myelin expression factor 3; paternally expressed gene 10 protein; retrotransposon gag domain-containing protein 3; retrotransposon-derived gag-like polyprotein; retrotransposon-derived protein PEG10 isoform 2; retrotransposon-derived protein PEG10; ty3/Gypsy-like protein", "tax_id": 10090, "disease": "pre-eclampsia (Disease Ontology:DOID:10591)", "pathway": " (mmu:170676)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11158386;11574691;12840045;15767280;16341224;16423995;17707377;17942406;21183079;21750661;24129315;25888968;30084848;30951545;31219806;34413232;34428180;9473521", "class_list": "", "function": "Characterization of a RNA pseudoknot as a frameshift signal for Edr programmed -1 ribosomal frameshifting. GeneRIF: Programmed -1 ribosomal frameshifting in mouse and human Peg10 genes. Publication Status: Online-Only, [RefSeq, PubMed]; Peg10 gene is imprinted, with preferential expression from the paternal allele, and its deletion results in early embryonic lethality., [RefSeq, PubMed]; Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:30951545, PubMed:34413232). Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232). Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232). Involved in placenta formation: required for trophoblast stem cells differentiation (PubMed:16341224, PubMed:30951545). Involved at the immediate early stage of adipocyte differentiation (PubMed:17707377). Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (By similarity). Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (PubMed:9473521)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; The ORF1-2 protein of PEG10, synthesized utilizing the most efficient -1 frameshift mechanism yet documented in vivo, will have an essential function that is intrinsic to the importance of PEG10 in mammals, [RefSeq, PubMed]; This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation, apoptosis and cancer development. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQ11", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1903561 extracellular vesicle", "go_biological_process": "GO:0110077 vesicle-mediated intercellular transport;GO:0030154 cell differentiation;GO:0051260 protein homooligomerization;GO:0006915 apoptotic process;GO:0001890 placenta development", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q7TN75-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBX6-1", "uniprot_id": [ { "id": "CP2S1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBX6", "type": "external" } ], "mass": 55632.0, "length": 501, "protein_name": "Cytochrome P450 2S1", "gene_name": "Cyp2s1", "organism": "Mouse", "refseq_name": "cytochrome P450 2S1", "refseq_ac": [ { "id": "NP_083051", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083051", "type": "external" } ], "gene_names_uniprotkb": "Cyp2s1", "gene_names_refseq": "1200011C15Rik; CYPIIS1; Cyp2s1", "protein_names_uniprotkb": "Cytochrome P450 2S1; 1.14.14.-; 4.2.1.152; 5.3.99.5; CYPIIS1; Hydroperoxy icosatetraenoate dehydratase; Thromboxane-A synthase", "protein_names_refseq": "cytochrome P450 2S1; hydroperoxy icosatetraenoate dehydratase; thromboxane-A synthase", "tax_id": 10090, "disease": "", "pathway": " (mmu:74134); (R-MMU-211958); (R-MMU-211981); (R-MMU-211999)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "17277313;21750661;23224081;31511258;34428180", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids. In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs). Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage., [UniProtKB, UniProtKB]; Cytochromes P450 are a group of heme-thiolate monooxygenases., [UniProtKB, UniProtKB]; Identify a novel regulatory cassette that mediates changes in Cyp2s1 expression, [RefSeq, PubMed]; No Cyp2s1 protein was detected in aortae from wild-type mice it was expressed in aortae and macrophage foam cells from ApoE(-/-) mice, [RefSeq, PubMed]; P450 2S1 is a fatty acid omega-1 hydroxylase, although the physiologic relevance of these oxidations remains to be established. Erratum:[Drug Metab Dispos. 2020 Mar;48(3):159. doi: 10.1124/dmd.119.089086err. PMID: 32001573], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "5.3.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.4", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "1.14.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.-", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "5.4.4.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.4.7", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016836 hydro-lyase activity;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008392 arachidonate epoxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006690 icosanoid metabolic process;GO:0042573 retinoic acid metabolic process;GO:0006805 xenobiotic metabolic process;GO:0006693 prostaglandin metabolic process;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DBX6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVJ2-1", "uniprot_id": [ { "id": "PSD13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVJ2", "type": "external" } ], "mass": 42809.0, "length": 376, "protein_name": "26S proteasome non-ATPase regulatory subunit 13", "gene_name": "Psmd13", "organism": "Mouse", "refseq_name": "26S proteasome non-ATPase regulatory subunit 13", "refseq_ac": [ { "id": "NP_036005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036005", "type": "external" } ], "gene_names_uniprotkb": "Psmd13", "gene_names_refseq": "Psmd13; S11", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 13; 26S proteasome regulatory subunit RPN9; 26S proteasome regulatory subunit S11; 26S proteasome regulatory subunit p40.5", "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 13; 26S proteasome regulatory subunit RPN9; 26S proteasome regulatory subunit S11; 26S proteasome regulatory subunit p40.5; 26S proteasome subunit p40.5", "tax_id": 10090, "disease": "", "pathway": " (mmu:23997); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-6798695); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 57, "publication_count": 7, "publication_id_list": "16857966;21750661;25605945;27802388;33300544;34428180;37507081", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TB19;Q3TR74;Q542R0", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0022624 proteasome accessory complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0008021 synaptic vesicle;GO:0000502 proteasome complex", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process;GO:2000311 regulation of AMPA receptor activity;GO:0007127 meiosis I", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9WVJ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1B5-1", "uniprot_id": [ { "id": "CPLX3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1B5", "type": "external" } ], "mass": 17586.0, "length": 158, "protein_name": "Complexin-3", "gene_name": "Cplx3", "organism": "Mouse", "refseq_name": "complexin-3", "refseq_ac": [ { "id": "NP_666335", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666335", "type": "external" } ], "gene_names_uniprotkb": "Cplx3", "gene_names_refseq": "Cplx3; CpxIII; ERGIC-53L; ERGL; Lamn1l; Lman1l", "protein_names_uniprotkb": "Complexin-3; CPX III; Complexin III", "protein_names_refseq": "CPX III; complexin III; complexin-3; lectin, mannose-binding, 1 like", "tax_id": 10090, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:235415)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;15911881;19386896;21750661;22694764;27335398", "class_list": "", "function": "Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (PubMed:19386896). Required for the maintenance of synaptic ultrastructure in the adult retina (PubMed:19386896). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (PubMed:15911881, PubMed:19386896, PubMed:27335398). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (PubMed:22694764, PubMed:27335398)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Results show that complexin 3 and complexin 4 are essential regulators of transmitter release at retinal ribbon synapses., [RefSeq, PubMed]; The novel CPXs III and IV may contribute to the unique release efficacy of retinal sensory neurons.(cOMPLEXIN III, MOUSE), [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q96AW7", "ec_number_list": [], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0019905 syntaxin binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043195 terminal bouton", "go_biological_process": "GO:0007601 visual perception;GO:0046928 regulation of neurotransmitter secretion;GO:0050804 modulation of chemical synaptic transmission;GO:0030073 insulin secretion;GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8R1B5-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BFS6-1", "uniprot_id": [ { "id": "CPPED_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BFS6", "type": "external" } ], "mass": 35248.0, "length": 312, "protein_name": "Serine/threonine-protein phosphatase CPPED1", "gene_name": "Cpped1", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase CPPED1 isoform 1", "refseq_ac": [ { "id": "NP_666179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666179", "type": "external" } ], "gene_names_uniprotkb": "Cpped1; Cstp1", "gene_names_refseq": "C530044N13Rik; Cpped1", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase CPPED1; 3.1.3.16; Calcineurin-like phosphoesterase domain-containing protein 1", "protein_names_refseq": "Vcalcineurin-like phosphoesterase domain containing 1; calcineurin-like phosphoesterase domain-containing protein 1; serine/threonine-protein phosphatase CPPED1 isoform 1; serine/threonine-protein phosphatase CPPED1", "tax_id": 10090, "disease": "", "pathway": " (mmu:223978); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;25153642;28135057", "class_list": "", "function": "Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UYF7;Q8BJQ3;Q8BYB7;Q8K236;Q8R3G2", "ec_number_list": [ { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BFS6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QY81-1", "uniprot_id": [ { "id": "PO210_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QY81", "type": "external" } ], "mass": 204101.0, "length": 1886, "protein_name": "Nuclear pore membrane glycoprotein 210", "gene_name": "Nup210", "organism": "Mouse", "refseq_name": "nuclear pore membrane glycoprotein 210 precursor", "refseq_ac": [ { "id": "NP_061285", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061285", "type": "external" } ], "gene_names_uniprotkb": "Nup210; Kiaa0906", "gene_names_refseq": "9830001L10; Nup210; Pom210; gp190; gp210", "protein_names_uniprotkb": "Nuclear pore membrane glycoprotein 210; Nuclear envelope pore membrane protein POM 210; Nuclear pore protein gp210; Nucleoporin Nup210; POM210; Pore membrane protein of 210 kDa", "protein_names_refseq": "nuclear envelope pore membrane protein POM 210; nuclear pore membrane glycoprotein 210 precursor; nuclear pore membrane glycoprotein 210; nuclear pore membrane protein 210; nuclear pore protein gp210; nucleoporin 210; nucleoporin Nup210; pore membrane protein of 210 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:54563); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885)", "pathway_count": 18, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10469352;11834739;14697343;17242355;19144319;21183079;21750661;25428506;30084848;30899004;34428180;34903738;34911810;39627609;40997131", "class_list": "", "function": "Expression of gp210 mRNA and protein was seen in mouse embryonic stem (ES) cells, supporting the view of cell-type specific NPCs in metazoans and suggesting the gp210 gene is regulated by specific control elements not shared by other nucleoporins., [RefSeq, PubMed]; Loss of Nup210 results in muscle repair delays and age-associated alterations in muscle integrity. Publication Status: Online-Only, [RefSeq, PubMed]; Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response. Publication Status: Online-Only, [RefSeq, PubMed]; Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity., [UniProtKB]; Separate functions for the two modules of the membrane-proximal cytokine binding domain of glycoprotein 190, the leukemia inhibitory factor low affinity receptor, in ligand binding and receptor activation, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q3U031;Q69ZW2;Q7TQM1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0015031 protein transport;GO:0051028 mRNA transport;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q9QY81-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80V63-1", "uniprot_id": [ { "id": "PRDM4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80V63", "type": "external" } ], "mass": 88145.0, "length": 803, "protein_name": "PR domain zinc finger protein 4", "gene_name": "Prdm4", "organism": "Mouse", "refseq_name": "PR domain zinc finger protein 4 isoform 1", "refseq_ac": [ { "id": "NP_857633", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_857633", "type": "external" } ], "gene_names_uniprotkb": "Prdm4", "gene_names_refseq": "1700031E19Rik; 2810470D21Rik; Prdm4; SC-1; SC1", "protein_names_uniprotkb": "PR domain zinc finger protein 4; 2.1.1.-; PR domain-containing protein 4", "protein_names_refseq": "PR domain zinc finger protein 4 isoform 1; PR domain zinc finger protein 4; PR domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:72843)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;23048031;30158592", "class_list": "", "function": "May function as a transcription factor involved in cell differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SC1 and PRMT5 are components of an epigenetic regulatory complex that maintains the 'stem-like' cellular state of the neural stem cells., [RefSeq, PubMed]; The role of butein in obesity and metabolic diseases, further highlighting that adipose PI3Kalpha-Akt1-Prdm4 axis is a regulator of energy expenditure. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the PR/SET family of zinc finger proteins. This protein has been shown to bind DNA in a sequence-specific manner and has been implicated in neural stem cell proliferation and differentiation. Pseudogenes have been identified on chromosomes 14 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RTL4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0008168 methyltransferase activity;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0035097 histone methyltransferase complex", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030308 negative regulation of cell growth;GO:0006366 transcription by RNA polymerase II;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80V63-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQJ7-1", "uniprot_id": [ { "id": "PTTG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQJ7", "type": "external" } ], "mass": 21725.0, "length": 199, "protein_name": "Securin", "gene_name": "Pttg1", "organism": "Mouse", "refseq_name": "securin isoform 1", "refseq_ac": [ { "id": "NP_001124526", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124526", "type": "external" } ], "gene_names_uniprotkb": "Pttg1; Pttg", "gene_names_refseq": "Pttg1; Pttg3; Pttg", "protein_names_uniprotkb": "Securin; Pituitary tumor-transforming gene 1 protein", "protein_names_refseq": "pituitary tumor-transforming 1; pituitary tumor-transforming gene 1 protein; securin isoform 1; securin", "tax_id": 10090, "disease": "", "pathway": " (mmu:30939); (R-MMU-174154); (R-MMU-174178); (R-MMU-2467813)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10713046;10727870;19144319;21183079;21750661;37159932;39093409", "class_list": "", "function": "MEIKIN expression and its C-terminal phosphorylation by PLK1 is closely related the metaphase-anaphase transition by affecting cyclin B1 and Securin stabilization in meiotic oocyte., [RefSeq, PubMed]; PTTG1 Reprograms Asparagine Metabolism to Promote Hepatocellular Carcinoma Progression., [RefSeq, PubMed]; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of p53/TP53. The negative regulation of p53/TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88887;Q9Z2E6", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0031072 heat shock protein binding;GO:0043022 ribosome binding;GO:0004869 cysteine-type endopeptidase inhibitor activity;GO:0140677 molecular function activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0005930 axoneme", "go_biological_process": "GO:0045143 homologous chromosome segregation;GO:0006281 DNA repair;GO:0007059 chromosome segregation;GO:0008285 negative regulation of cell population proliferation;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CQJ7-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811B5-1", "uniprot_id": [ { "id": "PRR3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q811B5", "type": "external" } ], "mass": 21167.0, "length": 190, "protein_name": "Proline-rich protein 3", "gene_name": "Prr3", "organism": "Mouse", "refseq_name": "proline-rich protein 3 isoform b", "refseq_ac": [ { "id": "NP_001159364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159364", "type": "external" } ], "gene_names_uniprotkb": "Prr3; Cat56", "gene_names_refseq": "4930540G07Rik; Cat56; Prr3", "protein_names_uniprotkb": "Proline-rich protein 3; MHC class I region proline-rich protein CAT56", "protein_names_refseq": "MHC class I region proline-rich protein Cat56; proline-rich protein 3 isoform b; proline-rich protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:75210); (R-MMU-9770562)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91YI5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004864 protein phosphatase inhibitor activity;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0000785 chromatin;GO:0072357 PTW/PP1 phosphatase complex", "go_biological_process": "GO:2000806 positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q811B5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VEK3-1", "uniprot_id": [ { "id": "HNRPU_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VEK3", "type": "external" } ], "mass": 87918.0, "length": 800, "protein_name": "Heterogeneous nuclear ribonucleoprotein U", "gene_name": "Hnrnpu", "organism": "Mouse", "refseq_name": "heterogeneous nuclear ribonucleoprotein U", "refseq_ac": [ { "id": "NP_058085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058085", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpu; Gm28062; Hnrpu", "gene_names_refseq": "Hnrnpu; Hnrpu; SAFA; Sp120; hnRNP U", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein U; SAF-A; Scaffold-attachment factor A; hnRNP U", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein U; heterogenous nuclear ribonucleoprotein U; nuclear matrix protein sp120; scaffold attachment factor A", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 54 (Disease Ontology:DOID:0080418); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:51810); (R-MMU-72163); (R-MMU-72203); (R-MMU-9770562)", "pathway_count": 4, "publication_count": 41, "publication_id_list": "10.1101/2023.09.13.557529;11850407;12686378;16022389;16452087;17242355;17947660;18332112;19129230;19144319;20833368;21183079;21235343;21750661;22162999;22872234;23806337;24129315;24463520;25428506;25605945;26244333;28784777;30084848;30779550;31219806;33300544;34203471;34418053;34428180;35820727;35984892;36288343;37453647;37507081;37984724;38016613;38625792;38797891;39627609;39927985", "class_list": "", "function": "CircIRAK3 exerts negative feedback regulation on inflammation by binding to HNRNP U and destabilizing proinflammatory cytokine mRNA in osteoarthritis and chondrogenesis., [RefSeq, PubMed]; DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression (PubMed:20833368, PubMed:21235343, PubMed:22162999, PubMed:26244333). Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability (By similarity). Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (PubMed:20833368, PubMed:26244333). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator (PubMed:21235343, PubMed:22162999). Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner. Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation. Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus. Negatively regulates glucocorticoid-mediated transcriptional activation (By similarity). Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling (PubMed:21235343). Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression (By similarity). Participates in the circadian regulation of the core clock component BMAL1 transcription (PubMed:18332112). Plays a role in the regulation of telomere length. Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis. Plays a role in mRNA stability. Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR). Plays a role in mitotic cell cycle regulation. Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression. Phosphorylation at Ser-58 by PLK1 is required for chromosome alignement and segregation and progression through mitosis. Also contributes to the targeting of AURKA to mitotic spindle MTs. Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides. Binds to chromatin-associated RNAs (caRNAs). Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in a chromatin-associated RNAs (caRNAs)-dependent manner (By similarity). Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi) (PubMed:20833368, PubMed:26244333). Binds the long non-coding H19 RNA. Binds to SMN1/2 pre-mRNAs at G/U-rich regions. Binds to small nuclear RNAs (snRNAs). Binds to the 3'-UTR of TNFA mRNA (By similarity). Also negatively regulates embryonic stem cell differentiation upon LIF signaling (PubMed:21235343). Required for embryonic development (PubMed:16022389). Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis (PubMed:28784777)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; HnRNP U participates in nuclear regulatory events that are involved in mammalian central and peripheral circadian clocks., [RefSeq, PubMed]; HnRNP-U engages a highly neddylated active SCF beta-TrCP which dissociates in the presence of a high-affinity substrate, resulting in the ubiquitination of the latter., [RefSeq, PubMed]; HnRNPU is required for spermatogonial stem cell pool establishment in mice., [RefSeq, PubMed]; Loss of HNRNPU in Skeletal Muscle Increases Intramuscular Infiltration of Ly6C Positive Cells, leading to Muscle Atrophy through Activation of NF-kappaB Signaling., [RefSeq, PubMed]; RNA-binding protein hnRNPU regulates multiple myeloma resistance to selinexor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "G3XA10;Q9R205", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003779 actin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0016071 mRNA metabolic process;GO:0070934 CRD-mediated mRNA stabilization;GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity;GO:2000648 positive regulation of stem cell proliferation;GO:2000767 positive regulation of cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 4.9, "record_id": "Q8VEK3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MQ5-1", "uniprot_id": [ { "id": "COPA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MQ5", "type": "external" } ], "mass": 65377.0, "length": 666, "protein_name": "Collagen alpha-1(XXV) chain", "gene_name": "Col25a1", "organism": "Mouse", "refseq_name": "collagen alpha-1(XXV) chain isoform 1", "refseq_ac": [ { "id": "NP_084114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084114", "type": "external" } ], "gene_names_uniprotkb": "Col25a1", "gene_names_refseq": "2700062B08Rik; CLAC-P; Col25a1", "protein_names_uniprotkb": "Collagen alpha-1(XXV) chain; CLAC-P", "protein_names_refseq": "collagen alpha-1(XXV) chain isoform 1; collagen alpha-1(XXV) chain; collagen-like Alzheimer amyloid plaque component; procollagen, type XXV, alpha 1", "tax_id": 10090, "disease": "congenital fibrosis of the extraocular muscles 5 (Disease Ontology:DOID:0081020)", "pathway": " (mmu:77018); (R-MMU-1442490); (R-MMU-1650814); (R-MMU-8948216)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "11927537;19548013;21750661;24453327;31875546", "class_list": "", "function": "CLAC-P/collagen XXV is a novel essential factor that regulates the initial phase of intramuscular motor innervation, which is required for subsequent target-dependent motoneuron survival and neuromuscular junction formation during development., [RefSeq, PubMed]; COL25A1 leads to Alzheimer's disease-like pathology in vivo, [RefSeq, PubMed]; Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin (By similarity)., [UniProtKB, UniProtKB]; Roles of Collagen XXV and Its Putative Receptors PTPsigma/delta in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G3X9H6", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:1990327 collagen type XXV trimer", "go_biological_process": "GO:0060385 axonogenesis involved in innervation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99MQ5-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHN7-1", "uniprot_id": [ { "id": "RLIG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHN7", "type": "external" } ], "mass": 37418.0, "length": 327, "protein_name": "RNA ligase 1", "gene_name": "Rlig1", "organism": "Mouse", "refseq_name": "RNA ligase 1", "refseq_ac": [ { "id": "NP_780337", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780337", "type": "external" } ], "gene_names_uniprotkb": "Rlig1; 4930430F08Rik", "gene_names_refseq": "4930430F08Rik; 4930571E09Rik; A730088G13Rik; C430008C19Rik; Rlig1; Rnl", "protein_names_uniprotkb": "RNA ligase 1; 6.5.1.3; RNA ligase; Rnl", "protein_names_refseq": "RNA ligase 1; RNA ligase; uncharacterized protein C12orf29 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68281)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Functions as an RNA ligase, in vitro. The ligation reaction entails three nucleotidyl transfer steps. In the first step, the RNA ligase reacts with ATP in the absence of nucleic acid to form a covalent ligase-AMP intermediate and release pyrophosphate. In step 2, the ligase-AMP binds to the nucleic acid and transfers the adenylate to the 5'-PO4 terminus to form an adenylylated intermediate. In step 3, the RNA ligase directs the attack of the 3'-OH on the 5'-phosphoanhydride linkage, resulting in a repaired 3'-5' phosphodiester and release of AMP. Exhibits selectivity for single-stranded RNA substrates and may not have nick-sealing activity on double-stranded DNA-RNA hybrids. May play a role in maintaining RNA integrity under stress conditions, for example in response to reactive oxygen species (ROS)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHP8;Q8BHV9", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0003972 RNA ligase (ATP) activity", "go_cellular_component": "", "go_biological_process": "GO:0000302 response to reactive oxygen species;GO:0042245 RNA repair;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BHN7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91W64-1", "uniprot_id": [ { "id": "CP270_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91W64", "type": "external" } ], "mass": 56020.0, "length": 489, "protein_name": "Cytochrome P450 2C70", "gene_name": "Cyp2c70", "organism": "Mouse", "refseq_name": "cytochrome P450 2C70 precursor", "refseq_ac": [ { "id": "NP_663474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663474", "type": "external" } ], "gene_names_uniprotkb": "Cyp2c70; Cyp2c-70; Cyp2c22", "gene_names_refseq": "Cyp2c70", "protein_names_uniprotkb": "Cytochrome P450 2C70; 1.14.14.-; CYPIIC70", "protein_names_refseq": "CYPIIC70; cytochrome P450 2C70 precursor; cytochrome P450 2C70", "tax_id": 10090, "disease": "", "pathway": " (mmu:226105)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;27638959;30084848;31506275;31645370;34428180;37384590", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in muricholic acid (MCA) synthesis (PubMed:27638959). Hydroxylates at the 6-beta position two major bile acids, chenodeoxycholic acid (CDCA) and ursodeoxycholic acid (UDCA) to form alpha-MCA and beta-MCA, respectively (PubMed:27638959). May regulate NR1H4/farnesoid X receptor signaling, as taurine-conjugated MCAs are antagonists of NR1H4. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:27638959)., [UniProtKB, PubMed]; A human-like bile acid pool induced by deletion of hepatic Cyp2c70 modulates effects of FXR activation in mice., [RefSeq, PubMed]; Absence of gut microbiota reduces neonatal survival and exacerbates liver disease in Cyp2c70-deficient mice with a human-like bile acid composition., [RefSeq, PubMed]; Cyp2c70 is a primary enzyme responsible for alpha-muricholic acid production., [RefSeq, PubMed]; Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5GLY9;Q80VW0;Q8R120;Q8VC00", "ec_number_list": [ { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042178 xenobiotic catabolic process;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91W64-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0Q8-1", "uniprot_id": [ { "id": "CLC4E_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0Q8", "type": "external" } ], "mass": 24431.0, "length": 214, "protein_name": "C-type lectin domain family 4 member E", "gene_name": "Clec4e", "organism": "Mouse", "refseq_name": "C-type lectin domain family 4 member E", "refseq_ac": [ { "id": "NP_064332", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064332", "type": "external" } ], "gene_names_uniprotkb": "Clec4e; Clecsf9; Mincle", "gene_names_refseq": "Clec4e; Clecsf9; Mincle", "protein_names_uniprotkb": "C-type lectin domain family 4 member E; C-type lectin superfamily member 9; Macrophage-inducible C-type lectin; Mincle", "protein_names_refseq": "C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 9; C-type lectin domain family 4 member E; C-type lectin, superfamily member 9; macrophage-inducible C-type lectin", "tax_id": 10090, "disease": "", "pathway": " (mmu:56619); (R-MMU-5621480)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10528209;18490740;18509109;18776906;19171887;20008526;21750661;23602766;38770013", "class_list": "glycogene", "function": "Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed:18490740, PubMed:18509109, PubMed:18776906, PubMed:19171887, PubMed:20008526, PubMed:23602766). The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions (PubMed:20008526, PubMed:23602766). Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells (PubMed:18776906, PubMed:23602766). Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 (Th1) and T-helper 17 (Th17) cell subtypes (PubMed:23602766). Also recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia and mediates macrophage activation (PubMed:19171887). Through recognition of DAMPs released upon nonhomeostatic cell death, enables immune sensing of damaged self and promotes inflammatory cell infiltration into the damaged tissue (PubMed:18776906)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Findings show that Mincle plays a novel and nonredundant role in the induction of inflammatory signaling in response to C. albicans infection, [RefSeq, PubMed]; Mincle is a receptor that senses nonhomeostatic cell death and thereby induces the production of inflammatory cytokines to drive the infiltration of neutrophils into damaged tissue., [RefSeq, PubMed]; Mincle may recognize specific geometry of alpha-mannosyl residues on Malassezia species and use this to distinguish them from other fungi., [RefSeq, PubMed]; Mincle receptor in macrophage and neutrophil contributes to the unresolved inflammation during the transition from acute kidney injury to chronic kidney disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 25, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0038187 pattern recognition receptor activity;GO:0051861 glycolipid binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0009897 external side of plasma membrane;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:0002292 T cell differentiation involved in immune response;GO:0038094 Fc-gamma receptor signaling pathway;GO:0002221 pattern recognition receptor signaling pathway;GO:0006955 immune response;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9R0Q8-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AWA9-1", "uniprot_id": [ { "id": "RBGP1_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AWA9", "type": "external" } ], "mass": 120798.0, "length": 1064, "protein_name": "Rab GTPase-activating protein 1", "gene_name": "Rabgap1", "organism": "Mouse", "refseq_name": "rab GTPase-activating protein 1 isoform b", "refseq_ac": [ { "id": "NP_001029132", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029132", "type": "external" } ], "gene_names_uniprotkb": "Rabgap1; Kiaa4104", "gene_names_refseq": "Gapcena; Rabgap1; mKIAA4104", "protein_names_uniprotkb": "Rab GTPase-activating protein 1; GAP and centrosome-associated protein; Rab6 GTPase-activating protein GAPCenA", "protein_names_refseq": "GAP and centrosome-associated protein; rab GTPase-activating protein 1 isoform b; rab GTPase-activating protein 1; rab6 GTPase activating protein (GAP and centrosome-associated); rab6 GTPase-activating protein GAPCenA", "tax_id": 10090, "disease": "", "pathway": " (mmu:227800); (R-MMU-8854214)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;22872234;32843574;34428180;36083289;37507081", "class_list": "", "function": "Biallelic loss-of-function variants in RABGAP1 cause a novel neurodevelopmental syndrome., [RefSeq, PubMed]; May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition (By similarity)., [UniProtKB, UniProtKB]; Rabgap1 promotes recycling of active beta1 integrins to support effective cell migration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTN1;Q8BQ32;Q8C8W3;Q8CD74;Q8R312", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "A2AWA9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4B2-1", "uniprot_id": [ { "id": "IRAK3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K4B2", "type": "external" } ], "mass": 68455.0, "length": 609, "protein_name": "Interleukin-1 receptor-associated kinase 3", "gene_name": "Irak3", "organism": "Mouse", "refseq_name": "interleukin-1 receptor-associated kinase 3 isoform 1", "refseq_ac": [ { "id": "NP_082955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082955", "type": "external" } ], "gene_names_uniprotkb": "Irak3", "gene_names_refseq": "4833428C18Rik; IRAK-M; Irak3", "protein_names_uniprotkb": "Interleukin-1 receptor-associated kinase 3; IL-1 receptor-associated kinase M; IRAK-3; IRAK-M; Inactive IL-1 receptor-associated kinase 3", "protein_names_refseq": "IL-1 receptor-associated kinase M; inactive IL-1 receptor-associated kinase 3; interleukin-1 receptor-associated kinase 3 isoform 1", "tax_id": 10090, "disease": "osteoporosis (Disease Ontology:DOID:11476); asthma (Disease Ontology:DOID:2841); tuberculosis (Disease Ontology:DOID:399); melioidosis (Disease Ontology:DOID:5052); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:73914); (R-MMU-9020702)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12054681;12150927;14660668;21750661;29686383;34428180;37402858;38016613;38838135", "class_list": "", "function": "CircIRAK3 exerts negative feedback regulation on inflammation by binding to HNRNP U and destabilizing proinflammatory cytokine mRNA in osteoarthritis and chondrogenesis., [RefSeq, PubMed]; Endotoxin tolerance was significantly reduced in macrophages from IRAK-M knockout mice. IRAK-M regulates TLR signaling and innate immune homeostasis., [RefSeq, PubMed]; IRAK3-mediated suppression of pro-inflammatory MyD88/IRAK signaling affects disease severity in acute pancreatitis. Publication Status: Online-Only, [RefSeq, PubMed]; Induction of IRAK-M and inhibition of kinase activity of IRAK-1 are crucial to PGN-induced tolerance in macrophages, [RefSeq, PubMed]; Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:12054681, PubMed:12150927, PubMed:29686383). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (PubMed:12054681, PubMed:12150927). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383)., [UniProtKB, PubMed, PubMed, PubMed]; Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C7U8;Q8CE40;Q8K1S8", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0001960 negative regulation of cytokine-mediated signaling pathway;GO:0070498 interleukin-1-mediated signaling pathway;GO:0006468 protein phosphorylation;GO:0032496 response to lipopolysaccharide;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8K4B2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56657-1", "uniprot_id": [ { "id": "CP240_MOUSE", "url": "https://www.uniprot.org/uniprot/P56657", "type": "external" } ], "mass": 55763.0, "length": 491, "protein_name": "Cytochrome P450 2C40", "gene_name": "Cyp2c40", "organism": "Mouse", "refseq_name": "cytochrome P450 2C40 precursor", "refseq_ac": [ { "id": "NP_034134", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034134", "type": "external" } ], "gene_names_uniprotkb": "Cyp2c40", "gene_names_refseq": "Cyp2c40", "protein_names_uniprotkb": "Cytochrome P450 2C40; 1.14.14.-; CYPIIC40", "protein_names_refseq": "CYPIIC40; cytochrome P450 2C40 precursor; cytochrome P450 2C40; cytochrome P450, 2c40", "tax_id": 10090, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); retinitis pigmentosa 89 (Disease Ontology:DOID:0112146); renal hypertension (Disease Ontology:DOID:1073); schizophrenia (Disease Ontology:DOID:5419); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:13099)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10908295;21750661;34428180;9721182", "class_list": "", "function": "A cytochrome P450 monooxygenase that may play a major role in the metabolism of arachidonic acid in the intestinal tract (PubMed:10908295, PubMed:9721182). Exhibits regioselective hydroxylase and epoxidase activity toward arachidonic acid, producing 16(R)-hydroxyeicosatetraenoic acid (HETE) and (14R,15S)-epoxyeicosatrienoic acid (EpETrE) as major products (PubMed:10908295). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:10908295)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RTP3", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" } ], "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0008404 arachidonate 14,15-epoxygenase activity;GO:0101020 estrogen 16-alpha-hydroxylase activity;GO:0005506 iron ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0002933 lipid hydroxylation;GO:0008210 estrogen metabolic process;GO:0046456 icosanoid biosynthetic process;GO:0042573 retinoic acid metabolic process;GO:0006805 xenobiotic metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P56657-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P1E7-1", "uniprot_id": [ { "id": "PRIPO_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P1E7", "type": "external" } ], "mass": 61330.0, "length": 537, "protein_name": "DNA-directed primase/polymerase protein", "gene_name": "Primpol", "organism": "Mouse", "refseq_name": "DNA-directed primase/polymerase protein", "refseq_ac": [ { "id": "NP_001001184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001184", "type": "external" } ], "gene_names_uniprotkb": "Primpol; Ccdc111", "gene_names_refseq": "Ccdc111; Primpol", "protein_names_uniprotkb": "DNA-directed primase/polymerase protein; 2.7.7.102; 2.7.7.7", "protein_names_refseq": "DNA-directed primase/polymerase protein; coiled-coil domain-containing protein 111", "tax_id": 10090, "disease": "myopia (Disease Ontology:DOID:11830)", "pathway": " (mmu:408022)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;24207056;26926109;29073063", "class_list": "", "function": "DNA primase and DNA polymerase required to tolerate replication-stalling lesions by bypassing them (PubMed:26926109, PubMed:29073063). Required to facilitate mitochondrial and nuclear replication fork progression by initiating de novo DNA synthesis using dNTPs and acting as an error-prone DNA polymerase able to bypass certain DNA lesions (By similarity). Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA (By similarity). Provides different translesion synthesis alternatives when DNA replication is stalled: able to synthesize DNA primers downstream of lesions, such as ultraviolet (UV) lesions, R-loops and G-quadruplexes, to allow DNA replication to continue (By similarity). Can also realign primers ahead of 'unreadable lesions' such as abasic sites and 6-4 photoproduct (6-4 pyrimidine-pyrimidinone), thereby skipping the lesion. Repriming avoids fork degradation while leading to accumulation of internal ssDNA gaps behind the forks (By similarity). Also able to incorporate nucleotides opposite DNA lesions such as 8oxoG, like a regular translesion synthesis DNA polymerase (By similarity). Also required for reinitiating stalled forks after UV damage during nuclear DNA replication (By similarity). Required for mitochondrial DNA (mtDNA) synthesis and replication, by reinitiating synthesis after UV damage or in the presence of chain-terminating nucleotides (PubMed:29073063). Prevents APOBEC family-mediated DNA mutagenesis by repriming downstream of abasic site to prohibit error-prone translesion synthesis (PubMed:26926109). Has non-overlapping function with POLH (By similarity). In addition to its role in DNA damage response, also required to maintain efficient nuclear and mitochondrial DNA replication in unperturbed cells (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; PrimPol can reinitiate stalled mtDNA replication and can prime mtDNA replication from nonconventional origins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BSR3", "ec_number_list": [ { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0030145 manganese ion binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005759 mitochondrial matrix;GO:0005657 replication fork;GO:0000428 DNA-directed RNA polymerase complex", "go_biological_process": "GO:0009411 response to UV;GO:0019985 translesion synthesis;GO:0006269 DNA replication, synthesis of primer;GO:0006264 mitochondrial DNA replication;GO:0043504 mitochondrial DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6P1E7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHA9-1", "uniprot_id": [ { "id": "PXYP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHA9", "type": "external" } ], "mass": 54937.0, "length": 480, "protein_name": "2-phosphoxylose phosphatase 1", "gene_name": "Pxylp1", "organism": "Mouse", "refseq_name": "2-phosphoxylose phosphatase 1", "refseq_ac": [ { "id": "NP_001276574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276574", "type": "external" } ], "gene_names_uniprotkb": "Pxylp1; Acpl2", "gene_names_refseq": "9430094M07Rik; Acpl2; C130099A20Rik; Pxylp1", "protein_names_uniprotkb": "2-phosphoxylose phosphatase 1; 3.1.3.-; Acid phosphatase-like protein 2", "protein_names_refseq": "2-phosphoxylose phosphatase 1; acid phosphatase-like 2; acid phosphatase-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:235534); (R-MMU-1971475)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZ12", "ec_number_list": [ { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0016791 phosphatase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006024 glycosaminoglycan biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BHA9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97371-1", "uniprot_id": [ { "id": "PSME1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97371", "type": "external" } ], "mass": 28673.0, "length": 249, "protein_name": "Proteasome activator complex subunit 1", "gene_name": "Psme1", "organism": "Mouse", "refseq_name": "proteasome activator complex subunit 1", "refseq_ac": [ { "id": "NP_035319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035319", "type": "external" } ], "gene_names_uniprotkb": "Psme1", "gene_names_refseq": "PA28a; Psme1", "protein_names_uniprotkb": "Proteasome activator complex subunit 1; 11S regulator complex subunit alpha; Activator of multicatalytic protease subunit 1; PA28alpha; PA28a; Proteasome activator 28 subunit alpha; REG-alpha", "protein_names_refseq": "11S regulator complex subunit alpha; PA28 alpha subunit; PA28alpha; REG-alpha; activator of multicatalytic protease subunit 1; protease (prosome, macropain) 28 subunit, alpha; proteasome (prosome, macropain) 28 subunit, alpha; proteasome activator 28 subunit alpha; proteasome activator complex subunit 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:19186); (R-MMU-1236974); (R-MMU-1236978); (R-MMU-9907900); (R-MMU-9912633)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11345588;18250455;21750661;25605945;26740625;30084848;32152506;34428180;37507081;9162094;9218537;9590240", "class_list": "", "function": "Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35561;Q9D841", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000502 proteasome complex;GO:0008537 proteasome activator complex", "go_biological_process": "GO:2000045 regulation of G1/S transition of mitotic cell cycle;GO:0061136 regulation of proteasomal protein catabolic process;GO:0019884 antigen processing and presentation of exogenous antigen", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P97371-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NVF9-1", "uniprot_id": [ { "id": "CPSF6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NVF9", "type": "external" } ], "mass": 59153.0, "length": 551, "protein_name": "Cleavage and polyadenylation specificity factor subunit 6", "gene_name": "Cpsf6", "organism": "Mouse", "refseq_name": "cleavage and polyadenylation specificity factor subunit 6 isoform 2", "refseq_ac": [ { "id": "NP_001013409", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013409", "type": "external" } ], "gene_names_uniprotkb": "Cpsf6", "gene_names_refseq": "4733401N12Rik; CFIM68; CFIM; Cpsf6; HPBRII-4; HPBRII-7", "protein_names_uniprotkb": "Cleavage and polyadenylation specificity factor subunit 6", "protein_names_refseq": "cleavage and polyadenylation specificity factor subunit 6 isoform 2; cleavage and polyadenylation specificity factor subunit 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:432508); (R-MMU-72187); (R-MMU-73856); (R-MMU-77595); (R-MMU-9770562)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "18032416;21750661;25428506;28135057;29799838;30084848;30779550;34418053;38416782", "class_list": "", "function": "Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery. Plays a role in mRNA export., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Downregulation of CPSF6 leads to global mRNA 3' UTR shortening and enhanced antiviral immune responses. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BX86;Q8BXI8", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0043023 ribosomal large subunit binding;GO:1990448 exon-exon junction complex binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005726 perichromatin fibrils;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0046833 positive regulation of RNA export from nucleus;GO:0006397 mRNA processing;GO:0051262 protein tetramerization;GO:0051290 protein heterotetramerization;GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6NVF9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4J2-1", "uniprot_id": [ { "id": "COE4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K4J2", "type": "external" } ], "mass": 64624.0, "length": 599, "protein_name": "Transcription factor COE4", "gene_name": "Ebf4", "organism": "Mouse", "refseq_name": "transcription factor COE4 isoform 2", "refseq_ac": [ { "id": "NP_001103983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103983", "type": "external" } ], "gene_names_uniprotkb": "Ebf4; Coe4", "gene_names_refseq": "Ebf3; Ebf4; O/E-4; Olf-1", "protein_names_uniprotkb": "Transcription factor COE4; EBF-4; Early B-cell factor 4; O/E-4; OE-4; Olf-1/EBF-like 4", "protein_names_refseq": "EBF-4; OE-4; Olf-1/EBF-like 4; early B-cell factor 3; transcription factor COE4 isoform 2; transcription factor COE4", "tax_id": 10090, "disease": "", "pathway": " (mmu:228598)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12139918;21750661;35939714", "class_list": "", "function": "The fourth member of the Olf-1/Ebf-like gene family, O/E-4, is expressed in the neuronal and basal cell layers of olfactory epithelium and may interact with other O/E family members to regulate gene expression in the olfactory sensory neurons., [RefSeq, PubMed]; Transcription factor (PubMed:12139918). Positively modulates transcription, perhaps less strongly than other early B cell factor/EBF family proteins (PubMed:12139918). Binds an EBF1/Olf-1 consensus site in vitro (PubMed:12139918)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BI82;A2BI83;Q8K4J1;Q8K4J3;Q8K4J4;Q8K4J5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0070231 T cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K4J2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63158-1", "uniprot_id": [ { "id": "HMGB1_MOUSE", "url": "https://www.uniprot.org/uniprot/P63158", "type": "external" } ], "mass": 24894.0, "length": 215, "protein_name": "High mobility group protein B1", "gene_name": "Hmgb1", "organism": "Mouse", "refseq_name": "high mobility group protein B1", "refseq_ac": [ { "id": "NP_001300823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300823", "type": "external" } ], "gene_names_uniprotkb": "Hmgb1; Hmg-1; Hmg1", "gene_names_refseq": "HMG-1; Hmg1; Hmgb1; SBP-1; p30", "protein_names_uniprotkb": "High mobility group protein B1; HMG-1; High mobility group protein 1", "protein_names_refseq": "amphoterin; high mobility group protein 1; high mobility group protein B1", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); hydrocephalus (Disease Ontology:DOID:10908); sciatic neuropathy (Disease Ontology:DOID:11446); Kawasaki disease (Disease Ontology:DOID:13378); obstructive jaundice (Disease Ontology:DOID:13603); alcohol use disorder (Disease Ontology:DOID:1574); atherosclerosis (Disease Ontology:DOID:1936); colon adenocarcinoma (Disease Ontology:DOID:234); high grade glioma (Disease Ontology:DOID:3070); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); brain infarction (Disease Ontology:DOID:3454); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); systemic scleroderma (Disease Ontology:DOID:418); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); periodontitis (Disease Ontology:DOID:824)", "pathway": " (mmu:15289); (R-MMU-140342); (R-MMU-3000471); (R-MMU-445989); (R-MMU-5620971); (R-MMU-5686938); (R-MMU-6798695); (R-MMU-879415); (R-MMU-933542)", "pathway_count": 9, "publication_count": 54, "publication_id_list": "10391216;10398600;12110890;16040616;16267105;1630928;16365390;17114460;17268551;17548579;17568691;17803946;18650382;18768881;19264983;19890330;20802146;20819940;21319304;21395369;21419643;21641551;21750661;22105604;22204001;22370717;22544226;22645316;22842346;23108142;23446148;23519706;23806337;23994764;24302768;24606906;2461949;25048472;25642769;25660970;26078984;26818617;28135057;28528544;33380312;34428180;35984892;36288343;37507081;39927985;7961836;8180479;9047378;9184213", "class_list": "", "function": "In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (PubMed:21395369). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (PubMed:25642769). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (PubMed:24302768). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (PubMed:17548579)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (PubMed:17268551). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (PubMed:19890330). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE. Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways (PubMed:17568691, PubMed:19264983, PubMed:21419643). Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12110890, PubMed:17548579). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12. TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2. In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (By similarity). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (By similarity). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (PubMed:18768881, PubMed:22204001). In adaptive immunity may be involved in enhancing immunity through activation of effector T-cells and suppression of regulatory T (TReg) cells (PubMed:21419643). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (PubMed:23108142). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (By similarity). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (By similarity). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (PubMed:25660970)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as a danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23446148, PubMed:23519706, PubMed:23994764, PubMed:25048472). Has proangiogenic activity (PubMed:16365390). May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]; Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity. May be involved in nucleotide excision repair (NER), mismatch repair (MMR) and base excision repair (BER) pathways, and double strand break repair such as non-homologous end joining (NHEJ) (PubMed:17803946, PubMed:18650382). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). In vitro can displace histone H1 from highly bent DNA. Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (PubMed:16040616). Facilitates binding of TP53 to DNA (By similarity). Proposed to be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1; however, this function has been questioned (PubMed:21641551, PubMed:24606906). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (PubMed:22544226)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P07155;P27109;P27428", "ec_number_list": [], "go_molecular_function": "GO:0010858 calcium-dependent protein kinase regulator activity;GO:0003681 bent DNA binding;GO:0008301 DNA binding, bending;GO:0050786 RAGE receptor binding;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0002270 plasmacytoid dendritic cell activation;GO:0002643 regulation of tolerance induction;GO:0002840 regulation of T cell mediated immune response to tumor cell;GO:0017055 negative regulation of RNA polymerase II transcription preinitiation complex assembly;GO:0032425 positive regulation of mismatch repair", "synthesized_glycan_count": 0, "hit_score": 5.7, "record_id": "P63158-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811W2-1", "uniprot_id": [ { "id": "CP26B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q811W2", "type": "external" } ], "mass": 57375.0, "length": 512, "protein_name": "Cytochrome P450 26B1", "gene_name": "Cyp26b1", "organism": "Mouse", "refseq_name": "cytochrome P450 26B1", "refseq_ac": [ { "id": "NP_001171184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171184", "type": "external" } ], "gene_names_uniprotkb": "Cyp26b1", "gene_names_refseq": "CP26; Cyp26b1; P450RAI-2", "protein_names_uniprotkb": "Cytochrome P450 26B1; 1.14.13.-; Cytochrome P450 retinoic acid-inactivating 2; Cytochrome P450RAI-2", "protein_names_refseq": "cytochrome P450 26B1; cytochrome P450 retinoic acid-inactivating 2; cytochrome P450, 26, retinoic acid B1; cytochrome P450RAI-2; retinoic acid hydroxylase", "tax_id": 10090, "disease": "osteochondrodysplasia (Disease Ontology:DOID:2256); craniosynostosis (Disease Ontology:DOID:2340); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:232174); (R-MMU-211916); (R-MMU-5365859)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11744378;12617826;15911617;16461896;16574820;19838304;21750661;22019272;34428180", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (Probable). RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (By similarity). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling (Probable). Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (By similarity). Involved in the convertion of atRA to all-trans-4-oxo-RA (Probable). Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (Probable). Shows preference for the following substrates: atRA > 9-cis-RA > 13-cis-RA (By similarity). Plays a central role in germ cell development: acts by degrading RAs in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis (PubMed:16461896, PubMed:16574820, PubMed:19838304). Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry (PubMed:16461896, PubMed:16574820, PubMed:19838304). Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints (PubMed:22019272). Essential for postnatal survival (PubMed:16461896, PubMed:16574820, PubMed:19838304)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Also has a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo., [UniProtKB, UniProtKB]; Differential expression of the retinoic acid-metabolizing enzymes CYP26A1 and CYP26B1 during murine organogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TM12", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "1.14.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" } ], "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0001972 retinoic acid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007283 spermatogenesis;GO:0010628 positive regulation of gene expression;GO:0061436 establishment of skin barrier;GO:0071300 cellular response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q811W2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZWS4-1", "uniprot_id": [ { "id": "CNIH3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZWS4", "type": "external" } ], "mass": 18976.0, "length": 160, "protein_name": "Protein cornichon homolog 3", "gene_name": "Cnih3", "organism": "Mouse", "refseq_name": "protein cornichon homolog 3 isoform 2", "refseq_ac": [ { "id": "NP_001153683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153683", "type": "external" } ], "gene_names_uniprotkb": "Cnih3", "gene_names_refseq": "2900075G08Rik; CNIH-3; Cnih3", "protein_names_uniprotkb": "Protein cornichon homolog 3; CNIH-3; Cornichon family AMPA receptor auxiliary protein 3", "protein_names_refseq": "protein cornichon homolog 3 isoform 2; protein cornichon homolog 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:72978); (R-MMU-204005); (R-MMU-5694530)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21750661;23522044;26239289;36849260", "class_list": "", "function": "Cnih3 Deletion Dysregulates Dorsal Hippocampal Transcription across the Estrous Cycle. Erratum:[eNeuro. 2023 Jun 7;10(6):ENEURO.0155-23.2023. doi: 10.1523/ENEURO.0155-23.2023. PMID: 37286355] Publication Status: Online-Only, [RefSeq, PubMed]; In cornichon-3 and cornichon-2 knockout mice there is a profound reduction of AMPA receptor synaptic transmission in the hippocampus., [RefSeq, PubMed]; Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization (By similarity)., [UniProtKB]; Study's convergent findings in humans and mice support CNIH3 involvement in the pathophysiology of opioid dependence, complementing prior studies implicating the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate system, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14BS0", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0016247 channel regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030425 dendrite;GO:0043198 dendritic shaft;GO:0045202 synapse;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0035249 synaptic transmission, glutamatergic;GO:0016192 vesicle-mediated transport;GO:2000311 regulation of AMPA receptor activity;GO:0051668 localization within membrane", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6ZWS4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V089-1", "uniprot_id": [ { "id": "RBM44_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V089", "type": "external" } ], "mass": 112281.0, "length": 1013, "protein_name": "RNA-binding protein 44", "gene_name": "Rbm44", "organism": "Mouse", "refseq_name": "RNA-binding protein 44", "refseq_ac": [ { "id": "NP_001028580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028580", "type": "external" } ], "gene_names_uniprotkb": "Rbm44; Gm817", "gene_names_refseq": "Gm817; Rbm44", "protein_names_uniprotkb": "RNA-binding protein 44; RNA-binding motif protein 44", "protein_names_refseq": "RNA-binding protein 44", "tax_id": 10090, "disease": "", "pathway": " (mmu:329207)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21364893;21750661;34678516", "class_list": "", "function": "Although RBM44 localizes to intercellular bridges during meiosis, RBM44 is not required for fertility in contrast to TEX14. Publication Status: Online-Only, [RefSeq, PubMed]; Component of intercellular bridges during meiosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells. Not required for fertility., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045171 intercellular bridge;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3V089-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O89086-1", "uniprot_id": [ { "id": "RBM3_MOUSE", "url": "https://www.uniprot.org/uniprot/O89086", "type": "external" } ], "mass": 16605.0, "length": 153, "protein_name": "RNA-binding protein 3", "gene_name": "Rbm3", "organism": "Mouse", "refseq_name": "RNA-binding protein 3 isoform 2", "refseq_ac": [ { "id": "NP_001159882", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159882", "type": "external" } ], "gene_names_uniprotkb": "Rbm3", "gene_names_refseq": "2600016C11Rik; Rbm3", "protein_names_uniprotkb": "RNA-binding protein 3; RNA-binding motif protein 3", "protein_names_refseq": "RNA binding motif protein 3; RNA-binding protein 3 isoform 2; putative RNA-binding protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:19652)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10793079;11470798;15684048;21183079;21750661;24129315;34428180;35820727;37453647;37463657;37982286;38688991", "class_list": "", "function": "Chronic social stress blunts core body temperature and molecular rhythms of Rbm3 and Cirbp in mouse lateral habenula., [RefSeq, PubMed]; Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation., [UniProtKB, PubMed]; Cold-shock proteome of myoblasts reveals role of RBM3 in promotion of mitochondrial metabolism and myoblast differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; RBM3 Accelerates Wound Healing of Skin in Diabetes through ERK1/2 Signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0043023 ribosomal large subunit binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006417 regulation of translation;GO:0009409 response to cold;GO:0006412 translation;GO:0045727 positive regulation of translation;GO:0035196 miRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O89086-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61028-1", "uniprot_id": [ { "id": "RAB8B_MOUSE", "url": "https://www.uniprot.org/uniprot/P61028", "type": "external" } ], "mass": 23603.0, "length": 207, "protein_name": "Ras-related protein Rab-8B", "gene_name": "Rab8b", "organism": "Mouse", "refseq_name": "ras-related protein Rab-8B", "refseq_ac": [ { "id": "NP_775589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775589", "type": "external" } ], "gene_names_uniprotkb": "Rab8b", "gene_names_refseq": "5930437D16; D330025I23Rik; Rab8b", "protein_names_uniprotkb": "Ras-related protein Rab-8B; 3.6.5.2", "protein_names_refseq": "RAB44, member RAS oncogene family; ras-related protein Rab-8B", "tax_id": 10090, "disease": "Smith-McCort dysplasia (Disease Ontology:DOID:0060247); Dyggve-Melchior-Clausen disease (Disease Ontology:DOID:0111167)", "pathway": " (mmu:235442); (R-MMU-8854214); (R-MMU-8873719); (R-MMU-8876198)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;18094055;18772196;19144319;26817838;29125462;33300544;34428180", "class_list": "", "function": "Rab8b is involved in trafficking of WNV particles from recycling endosomes to the plasma membrane., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB8B may be involved in polarized vesicular trafficking and neurotransmitter release (By similarity). May participate in cell junction dynamics in Sertoli cells (By similarity). May also participate in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U1Z3", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0030911 TPR domain binding;GO:0003924 GTPase activity;GO:0005102 signaling receptor binding;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0051286 cell tip;GO:0005739 mitochondrion;GO:0005768 endosome;GO:0005778 peroxisomal membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0051461 positive regulation of corticotropin secretion;GO:0006887 exocytosis;GO:0032456 endocytic recycling;GO:0045046 protein import into peroxisome membrane;GO:0019882 antigen processing and presentation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P61028-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVB0-1", "uniprot_id": [ { "id": "RBPMS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WVB0", "type": "external" } ], "mass": 21816.0, "length": 197, "protein_name": "RNA-binding protein with multiple splicing", "gene_name": "Rbpms", "organism": "Mouse", "refseq_name": "RNA-binding protein with multiple splicing isoform 1", "refseq_ac": [ { "id": "NP_001036139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036139", "type": "external" } ], "gene_names_uniprotkb": "Rbpms; Hermes", "gene_names_refseq": "2010300K22Rik; 2700019M19Rik; RBP-MS; Rbpms; hermes", "protein_names_uniprotkb": "RNA-binding protein with multiple splicing; Heart and RRM expressed sequence; Hermes; RBP-MS; RBPMS", "protein_names_refseq": "HEart, RRM Expressed Sequence; RNA-binding protein with multiple splicing (RBP-MS); RNA-binding protein with multiple splicing isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:19663)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10096065;21183079;21750661", "class_list": "", "function": "RNA binding protein that mediates the regulation of pre-mRNA alternative splicing (AS) (By similarity). Acts either as activator (FLNB, HSPG2, LIPA1, MYOCD, PTPRF and PPFIBP1) or repressor (TPM1, ACTN1, ITGA7, PIEZO1, LSM14B, MBNL1 and MBML2) of splicing events on specific pre-mRNA targets. Together with RNA binding proteins RBFOX2 and MBNL1/2, activates a splicing program associated with differentiated contractile vascular smooth muscle cells (SMC) by regulating AS of numerous pre-mRNA involved in actin cytoskeleton and focal adhesion machineries, suggesting a role in promoting a cell differentiated state (By similarity). Binds to introns, exons and 3'-UTR associated with tandem CAC trinucleotide motifs separated by a variable spacer region, at a minimum as a dimer. The minimal length of RNA required for RBPMS-binding tandem CAC motifs is 15 nt, with spacing ranging from 1 to 9 nt. Can also bind to CA dinucleotide repeats (By similarity). Mediates repression of TPM1 exon 3 by binding to CAC tandem repeats in the flanking intronic regions, followed by higher-order oligomerization and heterotypic interactions with other splicing regulators including MBNL1 and RBFOX2, which prevents assembly of ATP-dependent splicing complexes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q78HG1;Q9CPU5", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0097157 pre-mRNA intronic binding;GO:0060090 molecular adaptor activity;GO:0003713 transcription coactivator activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006979 response to oxidative stress;GO:0060395 SMAD protein signal transduction;GO:0000381 regulation of alternative mRNA splicing, via spliceosome;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9WVB0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1Z4-1", "uniprot_id": [ { "id": "PPR42_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1Z4", "type": "external" } ], "mass": 41151.0, "length": 357, "protein_name": "Protein phosphatase 1 regulatory subunit 42", "gene_name": "Ppp1r42", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 42", "refseq_ac": [ { "id": "NP_663730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663730", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r42; Lrrc67", "gene_names_refseq": "1700011J18Rik; 4930418G15Rik; Lrrc67; Ppp1r42; TLRR", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 42; Leucine-rich repeat-containing protein 67; TLRR; Testis leucine-rich repeat protein", "protein_names_refseq": "leucine rich repeat containing 67; protein phosphatase 1 regulatory subunit 42; testis leucine-rich repeat protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:69312)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17971504;18237440;19886865;21738792;21750661;40021952", "class_list": "", "function": "4930418G15Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Identification of a previously uncharacterized leucine-rich repeat protein that is expressed abundantly in the testis.[TLRR; NM_027033.1, NM_145692.1] Publication Status: Online-Only, [RefSeq, PubMed]; Our finding that TLRR is associated with microtubules in cultured cells suggests that TLRR may play a common role in modulating the cytoskeleton in other cell types besides male germ cells. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D5M1;Q9DAF9", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0070840 dynein complex binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005813 centrosome;GO:0015630 microtubule cytoskeleton;GO:0005815 microtubule organizing center;GO:0002177 manchette", "go_biological_process": "GO:0010921 regulation of phosphatase activity", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R1Z4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMG7-1", "uniprot_id": [ { "id": "RBGPR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMG7", "type": "external" } ], "mass": 152535.0, "length": 1366, "protein_name": "Rab3 GTPase-activating protein non-catalytic subunit", "gene_name": "Rab3gap2", "organism": "Mouse", "refseq_name": "rab3 GTPase-activating protein non-catalytic subunit", "refseq_ac": [ { "id": "NP_001157226", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157226", "type": "external" } ], "gene_names_uniprotkb": "Rab3gap2; Kiaa0839", "gene_names_refseq": "1110059F07Rik; 2010002H18Rik; 5830469C09; RAB3-GAP150; Rab3gap2; mKIAA0839", "protein_names_uniprotkb": "Rab3 GTPase-activating protein non-catalytic subunit; Rab3 GTPase-activating protein 150 kDa subunit; Rab3-GAP p150; Rab3-GAP regulatory subunit; Rab3-GAP150", "protein_names_refseq": "Rab3 GTPase-activating protein 150 kDa subunit; Rab3-GAP regulatory subunit; rab3 GTPase-activating protein non-catalytic subunit; rab3-GAP p150", "tax_id": 10090, "disease": "Warburg micro syndrome (Disease Ontology:DOID:0060237); Warburg micro syndrome 2 (Disease Ontology:DOID:0110717); Martsolf syndrome (Disease Ontology:DOID:0111586)", "pathway": " (mmu:98732); (R-MMU-6811436); (R-MMU-8876198)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;17114649;21183079;21750661;25428506;26495903;29187734;30084848;30899004;31219806;33300544;34428180;39627609", "class_list": "", "function": "Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which accelerates the otherwise slow GTP hydrolysis catalyzed by Rab proteins. The complex has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and has guanine nucleotide exchange factor (GEF) activity towards RAB18. The Rab3GAP complex acts as a GEF for RAB18 by promoting GDP release from RAB18 and the conversion of inactive RAB18-GDP to the active form RAB18-GTP. Recruits and stabilizes RAB18 at the cis-Golgi membrane in human fibroblasts where RAB18 is most likely activated. Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (By similarity). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as cell proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6PEU0;Q80TQ6;Q8BX72", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding;GO:0030234 enzyme regulator activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005776 autophagosome;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0097051 establishment of protein localization to endoplasmic reticulum membrane;GO:0043087 regulation of GTPase activity;GO:0016236 macroautophagy;GO:1903373 positive regulation of endoplasmic reticulum tubular network organization;GO:2000786 positive regulation of autophagosome assembly", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8BMG7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SUR0-1", "uniprot_id": [ { "id": "PUR4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SUR0", "type": "external" } ], "mass": 144629.0, "length": 1337, "protein_name": "Phosphoribosylformylglycinamidine synthase", "gene_name": "Pfas", "organism": "Mouse", "refseq_name": "phosphoribosylformylglycinamidine synthase", "refseq_ac": [ { "id": "NP_001152991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152991", "type": "external" } ], "gene_names_uniprotkb": "Pfas; Kiaa0361", "gene_names_refseq": "4432409B16Rik; FGAMS; FGAR-AT; FGARAT; Gm18; PURL; Pfas; Sofa", "protein_names_uniprotkb": "Phosphoribosylformylglycinamidine synthase; 6.3.5.3; FGAM synthase; FGAMS; FGAR amidotransferase; FGAR-AT; Formylglycinamide ribonucleotide amidotransferase; Formylglycinamide ribotide amidotransferase", "protein_names_refseq": "FGAM synthase; FGAR amidotransferase; formylglycinamide ribonucleotide amidotransferase; formylglycinamide ribotide amidotransferase; formylglycinamide ribotide synthetase; phosphoribosylformylglycinamidine synthase", "tax_id": 10090, "disease": "colon adenocarcinoma (Disease Ontology:DOID:234); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:237823); (R-MMU-73817)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;28528544;29337348;30899004;31219806;32782141;32848054;34203471;34428180;36852467;37828378;39627609", "class_list": "", "function": "Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity)., [UniProtKB]; Study observed FGAMS as distinct puncta throughout neuronal processes, where it co-localized with neurofilament heavy chain, tubulin, and mitochondria. Data provide insight into potential purine biosynthetic mechanisms utilized within neurons during homeostasis as well as viral infection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A4FUJ6;Q6A080", "ec_number_list": [ { "id": "6.3.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004642 phosphoribosylformylglycinamidine synthase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009410 response to xenobiotic stimulus;GO:0006541 glutamine metabolic process;GO:0006177 GMP biosynthetic process;GO:0006164 purine nucleotide biosynthetic process;GO:0006189 'de novo' IMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q5SUR0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1S0-1", "uniprot_id": [ { "id": "COQ6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1S0", "type": "external" } ], "mass": 51393.0, "length": 476, "protein_name": "Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial", "gene_name": "Coq6", "organism": "Mouse", "refseq_name": "ubiquinone biosynthesis monooxygenase COQ6, mitochondrial precursor", "refseq_ac": [ { "id": "NP_766170", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766170", "type": "external" } ], "gene_names_uniprotkb": "Coq6; COQ6", "gene_names_refseq": "5930427M12Rik; Coq6", "protein_names_uniprotkb": "Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; 1.14.15.45; 1.14.15.46; 2-methoxy-6-polyprenolphenol 4-hydroxylase; Coenzyme Q10 monooxygenase 6", "protein_names_refseq": "2-methoxy-6-polyprenolphenol 4-hydroxylase; coenzyme Q10 monooxygenase 6; coenzyme Q6 homolog; ubiquinone biosynthesis monooxygenase COQ6, mitochondrial precursor; ubiquinone biosynthesis monooxygenase COQ6, mitochondrial", "tax_id": 10090, "disease": "primary coenzyme Q10 deficiency 6 (Disease Ontology:DOID:0070243); nephrotic syndrome (Disease Ontology:DOID:1184); schwannomatosis (Disease Ontology:DOID:3204)", "pathway": " (mmu:217707); (R-MMU-2142789)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21540551;21750661;23806337;34428180;37507081", "class_list": "", "function": "FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-decaprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-decaprenyl)benzoic acid. Also acts downstream of COQ4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-decaprenyl)phenol to 2-methoxy-6-(all-trans-decaprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to COQ6 from NADPH via a ferredoxin/ferredoxin reductase system composed of FDX2 and FDXR., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJM2;Q80V13;Q8BJY5", "ec_number_list": [ { "id": "1.14.99.60", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.60", "type": "external" }, { "id": "1.14.13.253", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.253", "type": "external" }, { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" }, { "id": "4.1.1.130", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.130", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.114", "type": "external" }, { "id": "2.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.64", "type": "external" }, { "id": "1.14.15.45", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.45", "type": "external" }, { "id": "1.14.15.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.46", "type": "external" }, { "id": "2.1.1.201", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.201", "type": "external" } ], "go_molecular_function": "GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0071949 FAD binding;GO:0016491 oxidoreductase activity;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0106364 4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005794 Golgi apparatus;GO:0042995 cell projection", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R1S0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BLR2-1", "uniprot_id": [ { "id": "CPNE4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BLR2", "type": "external" } ], "mass": 62408.0, "length": 557, "protein_name": "Copine-4", "gene_name": "Cpne4", "organism": "Mouse", "refseq_name": "copine-4 isoform 2", "refseq_ac": [ { "id": "NP_082995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082995", "type": "external" } ], "gene_names_uniprotkb": "Cpne4", "gene_names_refseq": "3632411M23Rik; 4933406O10Rik; Cpne4", "protein_names_uniprotkb": "Copine-4; Copine IV", "protein_names_refseq": "copine-4 isoform 2; copine-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:74020)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BLR2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61074-1", "uniprot_id": [ { "id": "PPM1G_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61074", "type": "external" } ], "mass": 58728.0, "length": 542, "protein_name": "Protein phosphatase 1G", "gene_name": "Ppm1g", "organism": "Mouse", "refseq_name": "protein phosphatase 1G", "refseq_ac": [ { "id": "NP_032040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032040", "type": "external" } ], "gene_names_uniprotkb": "Ppm1g; Fin13; Ppm1c", "gene_names_refseq": "Fin13; Ppm1g", "protein_names_uniprotkb": "Protein phosphatase 1G; 3.1.3.16; FIN13; Fibroblast growth factor-inducible protein 13; PP2C-gamma; Protein phosphatase 1C; Protein phosphatase 2C isoform gamma; Protein phosphatase magnesium-dependent 1 gamma", "protein_names_refseq": "PP2C-gamma; fibroblast growth factor inducible 13; fibroblast growth factor-inducible protein 13; protein phosphatase 1C; protein phosphatase 1G; protein phosphatase magnesium-dependent 1 gamma", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:14208)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "21183079;21750661;22645316;23723158;23806337;24788674;25153642;26495903;34428180;38372470;39627609;8649829;9271424", "class_list": "", "function": "May be involved in regulation of cell cycle., [UniProtKB, PubMed]; Nuclear phosphatase PPM1G in cellular survival and neural development., [RefSeq, PubMed]; PPM1G regulates hepatic ischemia/reperfusion injury through STING-mediated inflammatory pathways in macrophages., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0006470 protein dephosphorylation;GO:0035970 peptidyl-threonine dephosphorylation;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q61074-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQR6-1", "uniprot_id": [ { "id": "PPP6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQR6", "type": "external" } ], "mass": 35159.0, "length": 305, "protein_name": "Serine/threonine-protein phosphatase 6 catalytic subunit", "gene_name": "Ppp6c", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 6 catalytic subunit", "refseq_ac": [ { "id": "NP_077171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077171", "type": "external" } ], "gene_names_uniprotkb": "Ppp6c", "gene_names_refseq": "2310003C10Rik; Pp6C; Ppp6c", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 6 catalytic subunit; 3.1.3.16; PP6C", "protein_names_refseq": "serine/threonine-protein phosphatase 6 catalytic subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:67857); (R-MMU-171319); (R-MMU-204005)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "16769727;16895907;21750661;22158480;26868000;32474700;32848054;34428180;34678516;35842423;37453647;37507081;38101002;38318686;38490577", "class_list": "", "function": "Alpha4 expression differentially increased or decreased phosphorylation of endogenous phosphoproteins, consistent with opposing effects on PP2A and PP6 [PP6], [RefSeq, PubMed]; Catalytic subunit of protein phosphatase 6 (PP6) (PubMed:32474700). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (By similarity). N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D13 During mitosis, regulates spindle positioning (By similarity). Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (By similarity). Acts as a regulator of innate immunity by mediating dephosphorylation CGAS, STING1 and RIGI (PubMed:32474700). Also participates in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIGI-mediated signaling activation (By similarity). Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1 (PubMed:32474700). CGAS dephosphorylation at 'Ser-420' impairs its ability to bind GTP, thereby inactivating it (PubMed:32474700)., [UniProtKB, UniProtKB, PubMed]; Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1. Publication Status: Online-Only, [RefSeq, PubMed]; Depletion of Ppp6c in hematopoietic and vascular endothelial cells causes embryonic lethality and decreased hematopoietic potential., [RefSeq, PubMed]; Neuron-specific loss of Ppp6c induces neonatal death and decreases the number of cortical neurons and interneurons., [RefSeq, PubMed]; Oncogenic K-Ras[G12V] cannot overcome proliferation failure caused by loss of Ppp6c in mouse embryonic fibroblasts., [RefSeq, PubMed]; PP6 regulates the sensitivity of GBM cells to radiation, and suggest small molecules disrupting or inhibiting PP6 association with DNA-PK is a potential radiosensitizer for GBM. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2ASL7", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0045087 innate immune response;GO:0000082 G1/S transition of mitotic cell cycle;GO:0006470 protein dephosphorylation;GO:0160049 negative regulation of cGAS/STING signaling pathway;GO:0140896 cGAS/STING signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9CQR6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C1Q2-1", "uniprot_id": [ { "id": "PDE11_MOUSE", "url": "https://www.uniprot.org/uniprot/P0C1Q2", "type": "external" } ], "mass": 104563.0, "length": 933, "protein_name": "Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A", "gene_name": "Pde11a", "organism": "Mouse", "refseq_name": "dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A", "refseq_ac": [ { "id": "NP_001074502", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074502", "type": "external" } ], "gene_names_uniprotkb": "Pde11a", "gene_names_refseq": "6330414F14Rik; A630086N24Rik; Gm350; PDE11A1; Pde11a", "protein_names_uniprotkb": "Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; 3.1.4.35; 3.1.4.53; cAMP and cGMP phosphodiesterase 11A", "protein_names_refseq": "cAMP and cGMP phosphodiesterase 11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A", "tax_id": 10090, "disease": "primary pigmented nodular adrenocortical disease 2 (Disease Ontology:DOID:0070547)", "pathway": " (mmu:241489); (R-MMU-418457); (R-MMU-418555)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15800654;20404172;21183079;21750661;27339393;36073342;38132157", "class_list": "", "function": "Conserved age-related increases in hippocampal PDE11A4 cause unexpected proteinopathies and cognitive decline of social associative memories., [RefSeq, PubMed]; PDE11A knockout mice show subtle psychiatric-disease-related deficits, including hyperactivity in an open field, increased sensitivity to the glutamate N-methyl-D-aspartate receptor antagonist MK-801, as well as deficits in social behaviors, [RefSeq, PubMed]; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:15800654). Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (By similarity)., [UniProtKB, PubMed, UniProtKB]; The Sleep Quality- and Myopia-Linked PDE11A-Y727C Variant Impacts Neural Physiology by Reducing Catalytic Activity and Altering Subcellular Compartmentalization of the Enzyme. Publication Status: Online-Only, [RefSeq, PubMed]; The data of this study suggest PDE11A is selectively required for the proper consolidation of recognition and associative social memories., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AKR2", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030553 cGMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity;GO:0004118 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0043204 perikaryon", "go_biological_process": "GO:0007165 signal transduction;GO:0010754 negative regulation of cGMP-mediated signaling;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P0C1Q2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43135-1", "uniprot_id": [ { "id": "COT2_MOUSE", "url": "https://www.uniprot.org/uniprot/P43135", "type": "external" } ], "mass": 45571.0, "length": 414, "protein_name": "COUP transcription factor 2", "gene_name": "Nr2f2", "organism": "Mouse", "refseq_name": "COUP transcription factor 2 isoform 1", "refseq_ac": [ { "id": "NP_033827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033827", "type": "external" } ], "gene_names_uniprotkb": "Nr2f2; Aporp1; Arp-1; Arp1; Tfcoup2", "gene_names_refseq": "2700033K02Rik; 9430015G03Rik; ARP-1; Aporp1; COUP-TF2; COUP-TFII; COUPTFB; EAR3; Nr2f2; SVP40; Tcfcoup2", "protein_names_uniprotkb": "COUP transcription factor 2; ARP-1; Apolipoprotein AI regulatory protein 1; COUP transcription factor II; COUP-TF II; COUP-TF2; Nuclear receptor subfamily 2 group F member 2", "protein_names_refseq": "COUP transcription factor 2 isoform 1; COUP transcription factor 2; COUP transcription factor II; COUP-TF II; apolipoprotein AI regulatory protein 1; apolipoprotein regulatory protein 1", "tax_id": 10090, "disease": "46,XX sex reversal 5 (Disease Ontology:DOID:0080943); hypertension (Disease Ontology:DOID:10763); dilated cardiomyopathy (Disease Ontology:DOID:12930); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:11819); (R-MMU-9940951)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11382775;21750661;28135057;28179430;7947324;8183930", "class_list": "", "function": "Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. May be required to establish ovary identity during early gonad development., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0060838 lymphatic endothelial cell fate commitment;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P43135-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH15-1", "uniprot_id": [ { "id": "CNO10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH15", "type": "external" } ], "mass": 81818.0, "length": 744, "protein_name": "CCR4-NOT transcription complex subunit 10", "gene_name": "Cnot10", "organism": "Mouse", "refseq_name": "CCR4-NOT transcription complex subunit 10", "refseq_ac": [ { "id": "NP_705813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705813", "type": "external" } ], "gene_names_uniprotkb": "Cnot10", "gene_names_refseq": "2600001P13Rik; Cnot10", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 10", "protein_names_refseq": "CCR4-NOT transcription complex subunit 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:78893); (R-MMU-429947); (R-MMU-6804115)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30084848;31219806;33104214;34428180;36852467", "class_list": "", "function": "Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RNF219 interacts with CCR4-NOT in regulating stem cell differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q05CH8;Q3TSS4;Q3UDS5;Q80VN2;Q8CI74", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0030014 CCR4-NOT complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0017148 negative regulation of translation;GO:0006402 mRNA catabolic process;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0006417 regulation of translation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BH15-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2Z4-1", "uniprot_id": [ { "id": "CND1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2Z4", "type": "external" } ], "mass": 155665.0, "length": 1392, "protein_name": "Condensin complex subunit 1", "gene_name": "Ncapd2", "organism": "Mouse", "refseq_name": "condensin complex subunit 1", "refseq_ac": [ { "id": "NP_666283", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666283", "type": "external" } ], "gene_names_uniprotkb": "Ncapd2; Capd2; Cnap1; Kiaa0159", "gene_names_refseq": "2810406C15Rik; 2810465G24Rik; CAP-D2; CNAP1; Ncapd2; mKIAA0159", "protein_names_uniprotkb": "Condensin complex subunit 1; Chromosome condensation-related SMC-associated protein 1; Chromosome-associated protein D2; Non-SMC condensin I complex subunit D2; XCAP-D2 homolog; mCAP-D2", "protein_names_refseq": "XCAP-D2 homolog; chromosome condensation-related SMC-associated protein 1; chromosome-associated protein D2; condensin complex subunit 1; mCAP-D2", "tax_id": 10090, "disease": "primary autosomal recessive microcephaly 21 (Disease Ontology:DOID:0051032)", "pathway": " (mmu:68298); (R-MMU-2514853)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "16144839;17525332;19131326;21183079;21750661;22872234;23531880;25428506;25474630;30084848;34229059;34428180;39627609", "class_list": "", "function": "Condensins I and II have overlapping and non-overlapping functions in Neural stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; Knock-down of a condensin subunit protein or YY1 reduced rearrangement of Igkappa Vkappa genes suggesting a direct role for YY1-condensin complexes in Igkappa locus structure and rearrangement., [RefSeq, PubMed]; NCAPD2 inhibits autophagy by regulating Ca(2+)/CAMKK2/AMPK/mTORC1 pathway and PARP-1/SIRT1 axis to promote colorectal cancer., [RefSeq, PubMed]; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The characterization of two novel E2F target genes, chromosome condensation-related SMC-associated protein 1 (Cnap1) and maternal embryonic leucine zipper kinase (Melk) is reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZQI1;Q8R0F2;Q8R3H0;Q922B7;Q923A3;Q9CS25;Q9CT32", "ec_number_list": [], "go_molecular_function": "GO:0042393 histone binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000793 condensed chromosome;GO:0034451 centriolar satellite", "go_biological_process": "GO:1905820 positive regulation of chromosome separation;GO:0051984 positive regulation of chromosome segregation;GO:0051301 cell division;GO:0007076 mitotic chromosome condensation;GO:0010032 meiotic chromosome condensation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8K2Z4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08121-1", "uniprot_id": [ { "id": "CO3A1_MOUSE", "url": "https://www.uniprot.org/uniprot/P08121", "type": "external" } ], "mass": 138943.0, "length": 1464, "protein_name": "Collagen alpha-1(III) chain", "gene_name": "Col3a1", "organism": "Mouse", "refseq_name": "collagen alpha-1(III) chain preproprotein", "refseq_ac": [ { "id": "NP_034060", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034060", "type": "external" } ], "gene_names_uniprotkb": "Col3a1", "gene_names_refseq": "Col3a-1; Col3a1; Tsk-2; Tsk2", "protein_names_uniprotkb": "Collagen alpha-1(III) chain", "protein_names_refseq": "collagen alpha-1(III) chain preproprotein; collagen alpha-1(III) chain; procollagen, type III, alpha 1", "tax_id": 10090, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); renal fibrosis (Disease Ontology:DOID:0050855); dilated cardiomyopathy (Disease Ontology:DOID:12930); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); bladder neck obstruction (Disease Ontology:DOID:13948); vascular type Ehlers-Danlos syndrome (Disease Ontology:DOID:14756); Ehlers-Danlos syndrome hypermobility type (Disease Ontology:DOID:14757); systemic scleroderma (Disease Ontology:DOID:418); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12825); (R-MMU-1442490); (R-MMU-1566977); (R-MMU-1650814); (R-MMU-186797); (R-MMU-2022090); (R-MMU-216083); (R-MMU-3000171); (R-MMU-3000178); (R-MMU-419037); (R-MMU-8874081); (R-MMU-8948216)", "pathway_count": 12, "publication_count": 14, "publication_id_list": "20485683;2054384;21750661;21768377;25428506;26495903;31219806;34203471;34428180;3443309;35820727;36583994;3972847;7926795", "class_list": "", "function": "Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12., [UniProtKB, PubMed]; This gene encodes the alpha-1 subunit of the fibril-forming type III collagen found in bone, cartilage, dentin, tendon, bone marrow stroma and other connective tissue. The encoded protein forms homotrimeric type III procollagen that undergoes proteolytic processing during fibril formation. A majority of mice lacking the encoded protein die within two days of birth but about 5% of the animals survive to adulthood. The surviving mice exhibit severe cortical malformation and experience significantly shorter lifespan. The mutant mouse named 'tight skin 2' exhibiting systemic sclerosis phenotype was found to harbor a missense point mutation in this gene. A pseudogene of this gene has been defined on chromosome 8. [provided by RefSeq, Nov 2015]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q61429;Q9CRN7", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005178 integrin binding;GO:0046872 metal ion binding;GO:0046332 SMAD binding;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005581 collagen trimer;GO:0005586 collagen type III trimer;GO:0005576 extracellular region", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007229 integrin-mediated signaling pathway;GO:0007507 heart development;GO:0030198 extracellular matrix organization;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P08121-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VEI3-1", "uniprot_id": [ { "id": "HYAL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VEI3", "type": "external" } ], "mass": 46132.0, "length": 412, "protein_name": "Hyaluronidase-3", "gene_name": "Hyal3", "organism": "Mouse", "refseq_name": "hyaluronidase-3 precursor", "refseq_ac": [ { "id": "NP_821139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_821139", "type": "external" } ], "gene_names_uniprotkb": "Hyal3; Hyl3", "gene_names_refseq": "Hyal3; Hyl3", "protein_names_uniprotkb": "Hyaluronidase-3; 3.2.1.35; Hyal-3; Hyaluronoglucosaminidase-3", "protein_names_refseq": "hyal-3; hyaluronidase-3 precursor; hyaluronidase-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:109685); (R-MMU-2024101); (R-MMU-2160916)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11929860;18234732;18653706;18762256;20586096;21732362;21750661", "class_list": "glycogene;glycosylhydrolase", "function": "Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3., [RefSeq, PubMed]; Data show that Hyal-1, but not Hyal-3,is an ovarian regulator factor for follicle development, and show an interrelationship between this enzyme and the follistatin/activin/Smad3 pathway., [RefSeq, PubMed]; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm (PubMed:20586096). Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage (PubMed:18653706). Has no hyaluronidase activity in embryonic fibroblasts in vitro (PubMed:18234732). Has no hyaluronidase activity in granulosa cells in vitro (PubMed:18653706)., [UniProtKB, PubMed, PubMed, PubMed]; Hyal3 may contribute to hyaluronan metabolism by augmenting the activity of Hyal1., [RefSeq, PubMed]; Hyal3 null sperm showed delayed cumulus penetration and reduced acrosomal exocytosis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 28, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B1AV95;Q8VBX7;Q8VI77", "ec_number_list": [ { "id": "3.2.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.35", "type": "external" } ], "go_molecular_function": "GO:0004415 hyalurononglucosaminidase activity;GO:0033906 hyaluronoglucuronidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005764 lysosome", "go_biological_process": "GO:0071493 cellular response to UV-B;GO:2000355 negative regulation of ovarian follicle development;GO:0006954 inflammatory response;GO:0007155 cell adhesion;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8VEI3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U1F9-1", "uniprot_id": [ { "id": "PHAG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U1F9", "type": "external" } ], "mass": 46549.0, "length": 429, "protein_name": "Phosphoprotein associated with glycosphingolipid-enriched microdomains 1", "gene_name": "Pag1", "organism": "Mouse", "refseq_name": "phosphoprotein associated with glycosphingolipid-enriched microdomains 1", "refseq_ac": [ { "id": "NP_001181960", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181960", "type": "external" } ], "gene_names_uniprotkb": "Pag1; Cbp; Pag", "gene_names_refseq": "Cbp; F730007C19Rik; Pag1; Pag", "protein_names_uniprotkb": "Phosphoprotein associated with glycosphingolipid-enriched microdomains 1; Csk-binding protein; Transmembrane phosphoprotein Cbp", "protein_names_refseq": "Csk-binding protein; phosphoprotein associated with glycosphingolipid-enriched microdomains 1; phosphoprotein transmembrane adaptor 1; phosphoprotein-associated with GEMs; transmembrane phosphoprotein Cbp", "tax_id": 10090, "disease": "", "pathway": " (mmu:94212); (R-MMU-180292); (R-MMU-202427)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10790433;11777944;12218089;12612075;12626544;14645715;14967142;16166631;16920712;17947660;19144319;21183079;27751872;31321783;32616310", "class_list": "", "function": "CADM1 suppresses c-Src activation by binding with Cbp on membrane lipid rafts and intervenes colon carcinogenesis., [RefSeq, PubMed]; Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Our findings illustrate that Cbp is an important regulator of Csk recruitment to the SFK Lyn in Eporesponsive erythroid cells., [RefSeq, PubMed]; PAG is a bona fide negative regulator of T-cell activation as a result of its capacity to recruit Csk., [RefSeq, PubMed]; PAG1 limits allergen-induced type 2 inflammation in the murine lung., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BFS1;Q9EQF3", "ec_number_list": [], "go_molecular_function": "GO:0042169 SH2 domain binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0002250 adaptive immune response;GO:0050868 negative regulation of T cell activation;GO:0050863 regulation of T cell activation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q3U1F9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811Q9-1", "uniprot_id": [ { "id": "PCY1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q811Q9", "type": "external" } ], "mass": 41900.0, "length": 369, "protein_name": "Choline-phosphate cytidylyltransferase B", "gene_name": "Pcyt1b", "organism": "Mouse", "refseq_name": "choline-phosphate cytidylyltransferase B isoform 2", "refseq_ac": [ { "id": "NP_808214", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808214", "type": "external" } ], "gene_names_uniprotkb": "Pcyt1b", "gene_names_refseq": "CTTbeta; Pcyt1b", "protein_names_uniprotkb": "Choline-phosphate cytidylyltransferase B; 2.7.7.15; CCT B; CCT-beta; CT B; CTP:phosphocholine cytidylyltransferase B; Phosphorylcholine transferase B", "protein_names_refseq": "CCT B; CCT-beta; CT B; CTP:phosphocholine cytidylyltransferase B; choline-phosphate cytidylyltransferase B isoform 2; choline-phosphate cytidylyltransferase B; phosphorylcholine transferase B", "tax_id": 10090, "disease": "", "pathway": " (mmu:236899); (R-MMU-1483191)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12842190;15143167;15345747;18423385;21183079;32900992", "class_list": "", "function": "Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis., [UniProtKB, PubMed, PubMed]; Long-term autophagy is sustained by activation of CCTbeta3 on lipid droplets. Publication Status: Online-Only, [RefSeq, PubMed]; Results suggest that the activities of alternative promoters provide for greater flexibility in the control of CTP:phosphocholine cytidylyltransferase beta isoform expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UEW0;Q80Y63;Q811Q8;Q8BKD2;Q8C085", "ec_number_list": [ { "id": "2.7.7.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.15", "type": "external" } ], "go_molecular_function": "GO:0004105 choline-phosphate cytidylyltransferase activity;GO:0042802 identical protein binding;GO:0031210 phosphatidylcholine binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006657 CDP-choline pathway;GO:0007283 spermatogenesis;GO:0006656 phosphatidylcholine biosynthetic process;GO:0001541 ovarian follicle development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q811Q9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0S9-1", "uniprot_id": [ { "id": "PRAF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0S9", "type": "external" } ], "mass": 20619.0, "length": 185, "protein_name": "Prenylated Rab acceptor protein 1", "gene_name": "Rabac1", "organism": "Mouse", "refseq_name": "prenylated Rab acceptor protein 1", "refseq_ac": [ { "id": "NP_034391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034391", "type": "external" } ], "gene_names_uniprotkb": "Rabac1; Pra1; Praf1; Pra", "gene_names_refseq": "2310040I06Rik; Gbpap1; PRA1; Rabac1; prenylin", "protein_names_uniprotkb": "Prenylated Rab acceptor protein 1; PRA1 family protein 1; Prenylin", "protein_names_refseq": "GTP binding protein associated protein 1; PRA1 family protein 1; prenylated Rab acceptor protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14470)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10964695;11335720;11535589;14979871;20173027;21750661;25428506;25605945;30084848;30925931;31219806;33259547;34428180;7782346", "class_list": "", "function": "Di-arginine and FFAT-like motifs retain a subpopulation of PRA1 at ER-mitochondria membrane contact sites. Publication Status: Online-Only, [RefSeq, PubMed]; General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI1 (By similarity)., [UniProtKB, PubMed]; Identification of novel PRA1 binding partners suggests a role for PRA1 within the early secretory pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 24, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDB4", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0070064 proline-rich region binding;GO:0051020 GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9Z0S9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04925-1", "uniprot_id": [ { "id": "PRIO_MOUSE", "url": "https://www.uniprot.org/uniprot/P04925", "type": "external" } ], "mass": 27977.0, "length": 254, "protein_name": "Major prion protein", "gene_name": "Prnp", "organism": "Mouse", "refseq_name": "major prion protein precursor", "refseq_ac": [ { "id": "NP_001265185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265185", "type": "external" } ], "gene_names_uniprotkb": "Prnp; Prn-p; Prp", "gene_names_refseq": "CD230; PrP; PrPC; PrPSc; PrP; Prn-i; Prn-p; Prnp; Sinc; prP27-30; prP33-35C", "protein_names_uniprotkb": "Major prion protein; PrP27-30; PrP33-35C; PrP", "protein_names_refseq": "major prion protein precursor; major prion protein", "tax_id": 10090, "disease": "fatal familial insomnia (Disease Ontology:DOID:0050433); Huntington's disease-like 1 (Disease Ontology:DOID:0090103); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); hyperglycemia (Disease Ontology:DOID:4195); Gerstmann-Straussler-Scheinker syndrome (Disease Ontology:DOID:4249); scrapie (Disease Ontology:DOID:5434); kuru (Disease Ontology:DOID:648)", "pathway": " (mmu:19122); (R-MMU-9609523)", "pathway_count": 2, "publication_count": 55, "publication_id_list": "10.1101/2023.09.13.557529;10200178;11032800;11571277;11756421;12610154;12732622;15003861;15007175;15161660;16272297;16297838;16492732;16817866;16923158;17270205;17313482;19242475;19349973;19381258;19524515;19568430;19587281;20098419;20377745;20599662;22522067;22948149;23469131;23629842;23903654;24117858;24493590;26495903;26821311;27501152;28011936;2890436;2894984;30899004;32513872;33300544;3462700;35820727;3923361;7535178;8035877;8637886;8645112;8700211;9261166;9280298;9765500;9799790;9837873", "class_list": "", "function": "Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (PubMed:12732622, PubMed:16492732, PubMed:19242475, PubMed:19568430)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 3, "mined_n_glycosites": 2, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 44, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0002020 protease binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0032700 negative regulation of interleukin-17 production;GO:0032703 negative regulation of interleukin-2 production;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006878 intracellular copper ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 10.3, "record_id": "P04925-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100110000001.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07978-1", "uniprot_id": [ { "id": "PRM2_MOUSE", "url": "https://www.uniprot.org/uniprot/P07978", "type": "external" } ], "mass": 13638.0, "length": 107, "protein_name": "Protamine-2", "gene_name": "Prm2", "organism": "Mouse", "refseq_name": "protamine-2", "refseq_ac": [ { "id": "NP_032959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032959", "type": "external" } ], "gene_names_uniprotkb": "Prm2", "gene_names_refseq": "Prm-2; Prm2", "protein_names_uniprotkb": "Protamine-2; Protamine mP2; Sperm histone P2; Sperm protamine P2", "protein_names_refseq": "protamine-2; sperm histone P2; sperm protamine P2", "tax_id": 10090, "disease": "", "pathway": " (mmu:19119)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12620939;1854346;2001695;27069551;28366643;32726616;3358932;3401454;3445973;35763544;3600661", "class_list": "", "function": "Loss of the cleaved-protamine 2 domain leads to incomplete histone-to-protamine exchange and infertility in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis, and are the major DNA-binding proteins in the nucleus of sperm in many vertebrates. They package the sperm DNA into a highly condensed complex in a volume less than 5% of a somatic cell nucleus. Many mammalian species have only one protamine (protamine 1); however, a few species, including human and mouse, have two. This gene encodes protamine 2, which is synthesized as a precursor and then cleaved to give rise to a family of protamine 2 peptides. [provided by RefSeq, Sep 2015]., [RefSeq, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046870 cadmium ion binding;GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007286 spermatid development;GO:0030261 chromosome condensation;GO:0006997 nucleus organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P07978-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PHZ5-1", "uniprot_id": [ { "id": "RB15B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PHZ5", "type": "external" } ], "mass": 97076.0, "length": 887, "protein_name": "Putative RNA-binding protein 15B", "gene_name": "Rbm15b", "organism": "Mouse", "refseq_name": "putative RNA-binding protein 15B", "refseq_ac": [ { "id": "NP_780611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780611", "type": "external" } ], "gene_names_uniprotkb": "Rbm15b", "gene_names_refseq": "1810017N16Rik; Rbm15b", "protein_names_uniprotkb": "Putative RNA-binding protein 15B; RNA-binding motif protein 15B", "protein_names_refseq": "RNA binding motif protein 15 pseudogene; putative RNA-binding protein 15B", "tax_id": 10090, "disease": "", "pathway": " (mmu:109095)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19586903;21183079;21750661;30084848;31219806", "class_list": "", "function": "RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex. Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist. Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation. Inhibits pre-mRNA splicing. Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1., [UniProtKB, UniProtKB]; The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C6G2", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0008380 RNA splicing;GO:0009048 dosage compensation by inactivation of X chromosome", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6PHZ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51150-1", "uniprot_id": [ { "id": "RAB7A_MOUSE", "url": "https://www.uniprot.org/uniprot/P51150", "type": "external" } ], "mass": 23490.0, "length": 207, "protein_name": "Ras-related protein Rab-7a", "gene_name": "Rab7a; Rab7", "organism": "Mouse", "refseq_name": "ras-related protein Rab-7a", "refseq_ac": [ { "id": "NP_001280581", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001280581", "type": "external" } ], "gene_names_uniprotkb": "Rab7a; Rab7; Rab7", "gene_names_refseq": "Rab7a; Rab7", "protein_names_uniprotkb": "Ras-related protein Rab-7a; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-7a", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 2 (Disease Ontology:DOID:0050539); Charcot-Marie-Tooth disease type 2B (Disease Ontology:DOID:0110159); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:19349); (R-MMU-2132295); (R-MMU-6798695); (R-MMU-8854214); (R-MMU-8873719); (R-MMU-8876198); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013407); (R-MMU-9013408); (R-MMU-9013423); (R-MMU-9035034)", "pathway_count": 13, "publication_count": 30, "publication_id_list": "12545426;12972561;16855591;18250455;19144319;20048159;21183079;21750661;22645316;23179371;23708524;24549040;24788674;26495903;26740625;27777970;28011936;28935714;32152506;33300544;33459343;34428180;35984892;37453647;37828378;38744829;38837607;38848175;39627609;8547311", "class_list": "", "function": "Enhancing Rab7 Activity by Inhibiting TBC1D5 Expression Improves Mitophagy in Alzheimer's Disease Models., [RefSeq, PubMed]; Targeting Rab7-Rilp Mediated Microlipophagy Alleviates Lipid Toxicity in Diabetic Cardiomyopathy., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. In its active state, RAB7A binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Also plays a central role in growth-factor-mediated cell signaling, nutrient-transporter-mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacteria. Plays a role in the fusion of phagosomes with lysosomes. In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA. Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation (By similarity). Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (PubMed:23708524). Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Required for vesicular trafficking and cell surface expression of ACE2 (By similarity). May play a role in PRPH neuronal intermediate filament assembly (PubMed:23179371)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "1.16.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.-", "type": "external" }, { "id": "2.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.1", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031267 small GTPase binding;GO:0019003 GDP binding;GO:1905394 retromer complex binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005739 mitochondrion;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0036466 synaptic vesicle recycling via endosome;GO:0090383 phagosome acidification;GO:0000045 autophagosome assembly;GO:0016042 lipid catabolic process;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P51150-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35293-1", "uniprot_id": [ { "id": "RAB18_MOUSE", "url": "https://www.uniprot.org/uniprot/P35293", "type": "external" } ], "mass": 23035.0, "length": 206, "protein_name": "Ras-related protein Rab-18", "gene_name": "Rab18", "organism": "Mouse", "refseq_name": "ras-related protein Rab-18 isoform 2 precursor", "refseq_ac": [ { "id": "NP_851415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851415", "type": "external" } ], "gene_names_uniprotkb": "Rab18", "gene_names_refseq": "Rab18", "protein_names_uniprotkb": "Ras-related protein Rab-18; 3.6.5.2", "protein_names_refseq": "GTP-binding protein Rab18; ras-related protein Rab-18 isoform 2 precursor; ras-related protein Rab-18", "tax_id": 10090, "disease": "Warburg micro syndrome 3 (Disease Ontology:DOID:0110718)", "pathway": " (mmu:19330); (R-MMU-6798695); (R-MMU-6811436); (R-MMU-8873719); (R-MMU-8876198)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "1555775;15914536;16207721;21183079;21750661;22645316;26063829;28528544;31599954;37453647;38523235;39413198;39627609;7706395;7916717", "class_list": "", "function": "2'3'-cGAMP interactome identifies 2'3'-cGAMP/Rab18/FosB signaling in cell migration control independent of innate immunity. Erratum:[Sci Adv. 2025 Jan 17;11(3):eadv6581. doi: 10.1126/sciadv.adv6581. PMID: 39823348], [RefSeq, PubMed]; Rab18 maintains homeostasis of subcutaneous adipose tissue to prevent obesity-induced metabolic disorders., [RefSeq, PubMed]; Rab18 regulates lipid droplet-associated membrane formation, [RefSeq, PubMed]; Results show that a Rab protein localizes directly to the monolayer surface of lipid droplets, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB18 is required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (By similarity). Also required for maintaining endoplasmic reticulum structure (By similarity). Plays a role in apical endocytosis/recycling (PubMed:7706395). Plays a key role in eye and brain development and neurodegeneration (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of the Ras-related small GTPases, which regulate membrane trafficking in organelles and transport vesicles. This protein is expressed predominantly in lipid droplets, organelles that store neutral lipids, and is proposed to play a role in lipolysis and lipogenesis. In humans mutations in this gene are associated with Warburg micro syndrome type 3. A pseudogene of this gene is located on chromosome X. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543V0", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005811 lipid droplet;GO:0045202 synapse;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0006886 intracellular protein transport;GO:0007420 brain development;GO:0034389 lipid droplet organization;GO:0001654 eye development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P35293-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62827-1", "uniprot_id": [ { "id": "RAN_MOUSE", "url": "https://www.uniprot.org/uniprot/P62827", "type": "external" } ], "mass": 24423.0, "length": 216, "protein_name": "GTP-binding nuclear protein Ran", "gene_name": "Ran", "organism": "Mouse", "refseq_name": "GTP-binding nuclear protein Ran", "refseq_ac": [ { "id": "NP_033417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033417", "type": "external" } ], "gene_names_uniprotkb": "Ran; Rasl2-8", "gene_names_refseq": "Ran", "protein_names_uniprotkb": "GTP-binding nuclear protein Ran; 3.6.5.-; GTPase Ran; Ras-like protein TC4; Ras-related nuclear protein", "protein_names_refseq": "GTP-binding nuclear protein Ran; GTPase Ran; ras-like protein TC4; ras-related nuclear protein", "tax_id": 10090, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:19384); (R-MMU-1655829); (R-MMU-5578749); (R-MMU-9615933)", "pathway_count": 4, "publication_count": 25, "publication_id_list": "10500213;10811801;12209622;1555775;18347012;23806337;25605945;25946333;26304119;30031227;32152506;33300544;34428180;35820727;35984892;36288343;37453647;37507081;38684907;39627609;39927985;7849398;7891706;8890215;9428644", "class_list": "", "function": "GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation., [UniProtKB, UniProtKB]; Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P17080;P28746;P28747;Q3U954;Q811M2;Q86V08;Q9CSP3;Q9CWI7;Q9CZA2;Q9UDJ5;Q9UEU9", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.n2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.n2", "type": "external" } ], "go_molecular_function": "GO:0061676 importin-alpha family protein binding;GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0000055 ribosomal large subunit export from nucleus;GO:1902570 protein localization to nucleolus;GO:0061015 snRNA import into nucleus;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P62827-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RI75-3", "uniprot_id": [ { "id": "RASEF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5RI75", "type": "external" } ], "mass": 79548.0, "length": 708, "protein_name": "Ras and EF-hand domain-containing protein", "gene_name": "Rasef", "organism": "Mouse", "refseq_name": "ras and EF-hand domain-containing protein isoform 1", "refseq_ac": [ { "id": "NP_001017427", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017427", "type": "external" } ], "gene_names_uniprotkb": "Rasef", "gene_names_refseq": "RAB45; Rasef", "protein_names_uniprotkb": "Ras and EF-hand domain-containing protein; 3.6.5.2; Ras-related protein Rab-45", "protein_names_refseq": "RAS and EF-hand domain-containing protein homolog; ras and EF-hand domain-containing protein isoform 1; ras-related protein Rab-45; testis-specific GTPase", "tax_id": 10090, "disease": "", "pathway": " (mmu:242505)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;23686708;38901651", "class_list": "", "function": "RASEF/Rab45 regulates the formation and sorting of zymogen granules and secretion of digestive enzymes by pancreatic acinar cells., [RefSeq, PubMed]; Rab GTPase that acts as a dynein adapter protein, thereby activating dynein-mediated transport and dynein-dynactin motility on microtubules (By similarity). RASEF-mediated dynein motility is Ca(2+)-independent (By similarity). Also regulates the formation and sorting of zymogen granules and secretion of digestive enzymes by pancreatic acinar cells (PubMed:38901651)., [UniProtKB, UniProtKB, PubMed]; Results show elevated RASEF promoted cell growth via enhanced ERK signaling and is associated with poor prognosis of non-small cell lung carcinoma (NSCLC), [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1Y7VIT3;B2RQ59;Q5RI76", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0070625 zymogen granule exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5RI75-3", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61411-1", "uniprot_id": [ { "id": "RASH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61411", "type": "external" } ], "mass": 21298.0, "length": 189, "protein_name": "GTPase HRas", "gene_name": "Hras", "organism": "Mouse", "refseq_name": "GTPase HRas isoform 1", "refseq_ac": [ { "id": "NP_001123915", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123915", "type": "external" } ], "gene_names_uniprotkb": "Hras; Hras1", "gene_names_refseq": "H-ras; Ha-ras; Harvey-ras; Hras-1; Hras1; Hras; Kras2; c-H-ras; c-Ha-ras; c-rasHa; ras", "protein_names_uniprotkb": "GTPase HRas; 3.6.5.2; H-Ras-1; Transforming protein p21; c-H-ras; p21ras", "protein_names_refseq": "GTPase HRas isoform 1; GTPase HRas; H-Ras-1; H-ras 1 protein; Harvey rat sarcoma virus oncogene 1; c-Ha-ras p21 protein; c-Ha-ras transgene; p21ras; transforming protein P21", "tax_id": 10090, "disease": "Costello syndrome (Disease Ontology:DOID:0050469); cardiomyopathy (Disease Ontology:DOID:0050700); Noonan syndrome 3 (Disease Ontology:DOID:0060581); RASopathy (Disease Ontology:DOID:0080690); epidermal nevus (Disease Ontology:DOID:0111162); large congenital melanocytic nevus (Disease Ontology:DOID:0111359); linear nevus sebaceous syndrome (Disease Ontology:DOID:0111530); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); obsessive-compulsive disorder (Disease Ontology:DOID:10933); urinary bladder cancer (Disease Ontology:DOID:11054); heart disease (Disease Ontology:DOID:114); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); leukemia (Disease Ontology:DOID:1240); autistic disorder (Disease Ontology:DOID:12849); cancer (Disease Ontology:DOID:162); squamous cell carcinoma (Disease Ontology:DOID:1749); autoimmune hepatitis (Disease Ontology:DOID:2048); kidney cancer (Disease Ontology:DOID:263); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); carcinoma (Disease Ontology:DOID:305); glioblastoma (Disease Ontology:DOID:3068); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); skin benign neoplasm (Disease Ontology:DOID:3165); papillary thyroid carcinoma (Disease Ontology:DOID:3969); cervical cancer (Disease Ontology:DOID:4362); seminoma (Disease Ontology:DOID:4440); liver cirrhosis (Disease Ontology:DOID:5082); phobic disorder (Disease Ontology:DOID:591); hepatocellular carcinoma (Disease Ontology:DOID:684); liver carcinoma (Disease Ontology:DOID:686); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:15461); (R-MMU-1169092); (R-MMU-1250347); (R-MMU-1433557); (R-MMU-171007); (R-MMU-179812); (R-MMU-180336); (R-MMU-186763); (R-MMU-1963640); (R-MMU-210993); (R-MMU-2179392); (R-MMU-2424491); (R-MMU-2871796); (R-MMU-375165); (R-MMU-3928662); (R-MMU-5218921); (R-MMU-5621575); (R-MMU-5654688); (R-MMU-5654693); (R-MMU-5654699); (R-MMU-5654700); (R-MMU-5654704); (R-MMU-5654706); (R-MMU-5654712); (R-MMU-5654719); (R-MMU-5658442); (R-MMU-5673000); (R-MMU-5673001); (R-MMU-5674135); (R-MMU-5675221); (R-MMU-8849471); (R-MMU-8851805); (R-MMU-9607240); (R-MMU-9634635); (R-MMU-9648002)", "pathway_count": 35, "publication_count": 11, "publication_id_list": "10869344;1347942;14500341;16580637;19906996;21750661;26495903;34428180;39196610;7526162;8922043", "class_list": "", "function": "Senescent cells inhibit mouse myoblast differentiation via the SASP-lipid 15d-PGJ2 mediated modification and control of HRas. Publication Status: Online-Only, [RefSeq, PubMed]; Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (By similarity). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 36, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F7BIB2;Q6P716;Q80WD2;Q811B9", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.4.26.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.26.1", "type": "external" }, { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.5.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.58", "type": "external" }, { "id": "2.5.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.59", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.100", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0044877 protein-containing complex binding;GO:0043495 protein-membrane adaptor activity;GO:0019003 GDP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000164 protein phosphatase type 1 complex;GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006897 endocytosis;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q61411-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHH2-1", "uniprot_id": [ { "id": "RAB9B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHH2", "type": "external" } ], "mass": 22704.0, "length": 201, "protein_name": "Ras-related protein Rab-9B", "gene_name": "Rab9b", "organism": "Mouse", "refseq_name": "ras-related protein Rab-9B", "refseq_ac": [ { "id": "NP_795945", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_795945", "type": "external" } ], "gene_names_uniprotkb": "Rab9b", "gene_names_refseq": "9330195C02Rik; Rab9b", "protein_names_uniprotkb": "Ras-related protein Rab-9B; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-9B", "tax_id": 10090, "disease": "", "pathway": " (mmu:319642); (R-MMU-6798695); (R-MMU-6811440); (R-MMU-8873719); (R-MMU-8876198); (R-MMU-9706019)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "21183079;25220469", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB9B is involved in the transport of proteins between the endosomes and the trans Golgi network (By similarity). May use NDE1/NDEL1 as an effector to interact with the dynein motor complex in order to control retrograde trafficking of RAB9-associated late endosomes to the TGN (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0030670 phagocytic vesicle membrane;GO:0005770 late endosome", "go_biological_process": "GO:0015031 protein transport;GO:0006898 receptor-mediated endocytosis;GO:0042147 retrograde transport, endosome to Golgi;GO:0032482 Rab protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BHH2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60855-1", "uniprot_id": [ { "id": "RIPK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60855", "type": "external" } ], "mass": 74854.0, "length": 656, "protein_name": "Receptor-interacting serine/threonine-protein kinase 1", "gene_name": "Ripk1", "organism": "Mouse", "refseq_name": "receptor-interacting serine/threonine-protein kinase 1", "refseq_ac": [ { "id": "NP_033094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033094", "type": "external" } ], "gene_names_uniprotkb": "Ripk1; Rinp; Rip", "gene_names_refseq": "D330015H01Rik; RIP-1; RIP; Rinp; Rip1; Ripk1", "protein_names_uniprotkb": "Receptor-interacting serine/threonine-protein kinase 1; 2.7.11.1; Cell death protein RIP; RIP-1; Receptor-interacting protein 1", "protein_names_refseq": "cell death protein RIP; receptor-interacting protein 1; receptor-interacting serine/threonine-protein kinase 1; serine/threonine-protein kinase RIP", "tax_id": 10090, "disease": "immunodeficiency 57 (Disease Ontology:DOID:0111952); squamous cell carcinoma (Disease Ontology:DOID:1749); epilepsy (Disease Ontology:DOID:1826); lichen planus (Disease Ontology:DOID:9201)", "pathway": " (mmu:19766); (R-MMU-140534); (R-MMU-2562578); (R-MMU-3295583); (R-MMU-3371378); (R-MMU-5213460); (R-MMU-5218900); (R-MMU-5357786); (R-MMU-5357905); (R-MMU-5357956); (R-MMU-5675482); (R-MMU-5689880); (R-MMU-5689896); (R-MMU-69416); (R-MMU-75893); (R-MMU-937041)", "pathway_count": 16, "publication_count": 42, "publication_id_list": "12654725;17301840;18239685;18442983;19590578;21183079;21750661;23283962;24557836;24813849;24813850;25428506;25459879;27819681;27819682;28528544;28701375;28842570;29440439;29883609;30084848;30185824;30237126;30867408;30988283;31219806;31358656;31457011;31511692;31519886;31519887;31827280;31827281;32269263;33273695;33311474;33364238;33397971;34471287;34990405;35156314;7538908", "class_list": "", "function": "Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:24557836, PubMed:24813849, PubMed:24813850, PubMed:27819681, PubMed:28842570, PubMed:31511692, PubMed:31827280, PubMed:31827281, PubMed:33397971). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:24557836, PubMed:24813849, PubMed:24813850, PubMed:28842570, PubMed:31519886, PubMed:31519887). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (PubMed:31519886, PubMed:31519887). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (PubMed:27819681, PubMed:27819682, PubMed:28842570, PubMed:29440439, PubMed:30988283, PubMed:31519886, PubMed:31519887). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (PubMed:24557836, PubMed:24813849, PubMed:24813850). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:24557836, PubMed:27819681, PubMed:27819682, PubMed:31358656). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:31358656). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (PubMed:30185824, PubMed:30867408). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (By similarity). Phosphorylates DAB2IP at 'Ser-728' in a TNF-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (By similarity). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (PubMed:12654725, PubMed:19590578)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 22, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0J3;Q8CD90", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "3.4.22.61", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.61", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0070513 death domain binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0043235 receptor complex;GO:0097342 ripoptosome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0070105 positive regulation of interleukin-6-mediated signaling pathway;GO:0001934 positive regulation of protein phosphorylation;GO:0006954 inflammatory response;GO:0006979 response to oxidative stress;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "Q60855-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERU9-1", "uniprot_id": [ { "id": "RBP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERU9", "type": "external" } ], "mass": 341121.0, "length": 3053, "protein_name": "E3 SUMO-protein ligase RanBP2", "gene_name": "Ranbp2", "organism": "Mouse", "refseq_name": "E3 SUMO-protein ligase RanBP2", "refseq_ac": [ { "id": "NP_035370", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035370", "type": "external" } ], "gene_names_uniprotkb": "Ranbp2", "gene_names_refseq": "A430087B05Rik; NUP358; Ranbp2", "protein_names_uniprotkb": "E3 SUMO-protein ligase RanBP2; 2.3.2.-; Ran-binding protein 2; RanBP2", "protein_names_refseq": "E3 SUMO-protein ligase RanBP2; E3 SUMO-protein transferase RanBP2; ran-binding protein 2", "tax_id": 10090, "disease": "inflammatory myofibroblastic tumor (Disease Ontology:DOID:0050905); brain disease (Disease Ontology:DOID:936); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:19386); (R-MMU-141430); (R-MMU-141444); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 25, "publication_count": 46, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;11353387;16332688;16452087;17242355;19131326;19144319;20173027;21183079;21606357;22517741;22645316;23641069;23806337;24129315;25428506;25605945;26495903;27802388;28528544;29187734;30016717;30059200;30084848;30779550;31219806;31599954;32782141;32848054;34428180;34678516;35771867;35822049;36852467;38657106;38838144;39627609;40021952;40885482;40997131;7559465;8603673;8857542;9037092;9733766", "class_list": "", "function": "E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Inhibits EIF4E-dependent mRNA export. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity., [UniProtKB, UniProtKB]; Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation., [RefSeq, PubMed]; Proteostatic Remodeling of Small Heat Shock Chaperones horizontal line Crystallins by Ran-Binding Protein 2 horizontal line and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain., [RefSeq, PubMed]; Reports identification of a binding domain in RanBP2, the cyclophilin-like domain, toward components of the 19S cap of the proteasome, [RefSeq, PubMed]; Reports identification of the cyclophilin-related protein, RanBP2 (note at the time the protein was not designated RanBP2), and the cis-trans prolyl isomerase activity of its cyclophilin domain, [RefSeq, PubMed]; Reports interaction of the RBD4 and CY domains of RanBP2 with red/green opsin and the chaperone activity of these domains toward red/green opsin., [RefSeq, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 17, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 17, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 17, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 41, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 3, "glyco_site_count": 22, "binding_glycan_count": 0, "secondary_ac_list": "E9QM01;Q61992;Q8C9K9", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.2", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" } ], "go_molecular_function": "GO:0019209 kinase activator activity;GO:0061665 SUMO ligase activity;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm", "go_biological_process": "GO:0046832 negative regulation of RNA export from nucleus;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006913 nucleocytoplasmic transport;GO:0016925 protein sumoylation;GO:0001975 response to amphetamine", "synthesized_glycan_count": 0, "hit_score": 7.3, "record_id": "Q9ERU9-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61249-1", "uniprot_id": [ { "id": "CNCG_MOUSE", "url": "https://www.uniprot.org/uniprot/P61249", "type": "external" } ], "mass": 9028.0, "length": 83, "protein_name": "Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma", "gene_name": "Pde6h", "organism": "Mouse", "refseq_name": "retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma", "refseq_ac": [ { "id": "NP_076387", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076387", "type": "external" } ], "gene_names_uniprotkb": "Pde6h", "gene_names_refseq": "A930033D18Rik; PDEgamma; Pde6h", "protein_names_uniprotkb": "Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; 3.1.4.35; GMP-PDE gamma", "protein_names_refseq": "GMP-PDE gamma; cone phosphodiesterase 6 gamma; cone-like cGMP-phosphodiesterase 6 gamma subunit type 2; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma", "tax_id": 10090, "disease": "achromatopsia 6 (Disease Ontology:DOID:0081025)", "pathway": " (mmu:78600)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11944991;16641226;21750661;25739440", "class_list": "", "function": "Our results show that the PDE6gamma binding sites of PDE6 alpha and beta are accessible to excess (presumably cytoplasmic) PDE6gamma in the light, once endogenous PDE6gamma has been displaced from its binding site by Talpha-GTP., [RefSeq, PubMed]; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Pde6h deficiency mice suggests no defects in cone/rod-driven retinal signaling and therefore preserved visual functions., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q14BP9;Q9D1Y6;Q9EP63", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0030553 cGMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity", "go_cellular_component": "GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0043410 positive regulation of MAPK cascade;GO:0045745 positive regulation of G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P61249-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A891-1", "uniprot_id": [ { "id": "CMTA1_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A891", "type": "external" } ], "mass": 184319.0, "length": 1682, "protein_name": "Calmodulin-binding transcription activator 1", "gene_name": "Camta1", "organism": "Mouse", "refseq_name": "calmodulin-binding transcription activator 1 isoform 1", "refseq_ac": [ { "id": "NP_001075026", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075026", "type": "external" } ], "gene_names_uniprotkb": "Camta1; Kiaa0833", "gene_names_refseq": "1810059M14Rik; 2310058O09Rik; Camta1; mKIAA0833", "protein_names_uniprotkb": "Calmodulin-binding transcription activator 1", "protein_names_refseq": "calmodulin-binding transcription activator 1 isoform 1", "tax_id": 10090, "disease": "nonprogressive cerebellar ataxia with mental retardation (Disease Ontology:DOID:0050998)", "pathway": " (mmu:100072)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;25049392;25428506;27194798;30084848;34203471;35820727", "class_list": "", "function": "CAMTA1 plays an essential role in the control of Purkinje cell function and survival., [RefSeq, PubMed]; Study provides experimental evidence that confirms previous human genetic studies and establishes calmodulin-binding transcription activator, CAMTA1 as a regulator of long-term memory formation. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional activator., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A892;A2A896;A2A897;A2A898;B2KGR3;B2KGR4;Q80TQ8", "ec_number_list": [], "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0043565 sequence-specific DNA binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050885 neuromuscular process controlling balance;GO:0070886 positive regulation of calcineurin-NFAT signaling cascade", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A2A891-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35448-1", "uniprot_id": [ { "id": "PPT2_MOUSE", "url": "https://www.uniprot.org/uniprot/O35448", "type": "external" } ], "mass": 34366.0, "length": 302, "protein_name": "Lysosomal thioesterase PPT2", "gene_name": "Ppt2", "organism": "Mouse", "refseq_name": "lysosomal thioesterase PPT2 precursor", "refseq_ac": [ { "id": "NP_001289322", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289322", "type": "external" } ], "gene_names_uniprotkb": "Ppt2", "gene_names_refseq": "0610007M19Rik; Ppt2", "protein_names_uniprotkb": "Lysosomal thioesterase PPT2; 3.1.2.2; PPT-2", "protein_names_refseq": "lysosomal thioesterase PPT2 precursor; lysosomal thioesterase PPT2", "tax_id": 10090, "disease": "neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503)", "pathway": " (mmu:54397); (R-MMU-75105)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11717424;14528005;14656967;18299400;21750661;21952136;25428506;25428507;26740625;30084848;30779550;30899004;31616917;34428180;35820727", "class_list": "", "function": "Catalyzes the cleavage of thioester bonds from S-palmitoyl-CoA or S-palmitoyl-N-acetylcysteamine (unbranched structures) but does not have activity against palmitoylcysteine or palmitoylated proteins, branched structures or bulky head groups. Conversely, hydrolyzes both long and short chain fatty acyl-CoA substrate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PPT2 deficiency in mice causes an unusual form of neuronal ceroid lipofuscinosis with striking visceral manifestations. All PPT2-deficient mice displayed a neurodegenerative phenotype with spasticity and ataxia by 15 mo., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q80WP5", "ec_number_list": [ { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" } ], "go_molecular_function": "GO:0047617 fatty acyl-CoA hydrolase activity;GO:0016790 thiolester hydrolase activity;GO:0098599 palmitoyl hydrolase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005764 lysosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "O35448-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZU6-1", "uniprot_id": [ { "id": "PXDC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZU6", "type": "external" } ], "mass": 26448.0, "length": 231, "protein_name": "PX domain-containing protein 1", "gene_name": "Pxdc1", "organism": "Mouse", "refseq_name": "PX domain-containing protein 1 isoform 2", "refseq_ac": [ { "id": "NP_080107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080107", "type": "external" } ], "gene_names_uniprotkb": "Pxdc1; 1300014I06Rik", "gene_names_refseq": "1300014I06Rik; Pxdc1", "protein_names_uniprotkb": "PX domain-containing protein 1", "protein_names_refseq": "PX domain-containing protein 1 isoform 2; PX domain-containing protein 1; PX domain-containing protein C6orf145 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66895)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30084848", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0PJ93;Q9DBE6", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8JZU6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z210-1", "uniprot_id": [ { "id": "PX11B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z210", "type": "external" } ], "mass": 28710.0, "length": 259, "protein_name": "Peroxisomal membrane protein 11B", "gene_name": "Pex11b", "organism": "Mouse", "refseq_name": "peroxisomal membrane protein 11B isoform 1", "refseq_ac": [ { "id": "NP_001155859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155859", "type": "external" } ], "gene_names_uniprotkb": "Pex11b", "gene_names_refseq": "PEX11beta; Pex11b; Pex11pbeta", "protein_names_uniprotkb": "Peroxisomal membrane protein 11B; PEX11-beta; Peroxin-11B; Peroxisomal biogenesis factor 11B; Protein PEX11 homolog beta", "protein_names_refseq": "PEX11-beta; peroxin-11B; peroxisomal biogenesis factor 11b; peroxisomal membrane protein 11B isoform 1; peroxisomal membrane protein 11B; protein PEX11 homolog beta", "tax_id": 10090, "disease": "peroxisome biogenesis disorder 14B (Disease Ontology:DOID:0081274); Zellweger syndrome (Disease Ontology:DOID:905)", "pathway": " (mmu:18632); (R-MMU-9603798)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11839773;12024045;21750661;21954064;25428506;31219806;9792670", "class_list": "", "function": "Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface., [UniProtKB, PubMed, UniProtKB, PubMed]; The alterations in the brain caused by the deletion of a single allele of the Pex11beta gene, are reported., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C4G1;Q9D090", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007165 signal transduction;GO:0016559 peroxisome fission;GO:0007031 peroxisome organization;GO:0044375 regulation of peroxisome size", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z210-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U898-1", "uniprot_id": [ { "id": "CSN9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U898", "type": "external" } ], "mass": 6197.0, "length": 57, "protein_name": "COP9 signalosome complex subunit 9", "gene_name": "Cops9", "organism": "Mouse", "refseq_name": "COP9 signalosome complex subunit 9", "refseq_ac": [ { "id": "NP_001156897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156897", "type": "external" } ], "gene_names_uniprotkb": "Cops9; Myeov2", "gene_names_refseq": "1110002M09Rik; Cops9; Myeov2", "protein_names_uniprotkb": "COP9 signalosome complex subunit 9", "protein_names_refseq": "COP9 signalosome complex subunit 9; myeloma overexpressed 2; myeloma-overexpressed gene 2 protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66915)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Plays a role in cell proliferation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0008180 COP9 signalosome", "go_biological_process": "GO:1904750 negative regulation of protein localization to nucleolus;GO:0008284 positive regulation of cell population proliferation;GO:0034644 cellular response to UV;GO:2000435 negative regulation of protein neddylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3U898-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWN7-1", "uniprot_id": [ { "id": "CNO11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWN7", "type": "external" } ], "mass": 54959.0, "length": 505, "protein_name": "CCR4-NOT transcription complex subunit 11", "gene_name": "Cnot11", "organism": "Mouse", "refseq_name": "CCR4-NOT transcription complex subunit 11", "refseq_ac": [ { "id": "NP_082319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082319", "type": "external" } ], "gene_names_uniprotkb": "Cnot11; D1Bwg0212e", "gene_names_refseq": "2410015L18Rik; C40; Cnot11; D1Bwg0212e", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 11", "protein_names_refseq": "CCR4-NOT transcription complex subunit 11; UPF0760 protein C2orf29 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:52846); (R-MMU-429947); (R-MMU-6804115)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;24129315;25428506", "class_list": "", "function": "Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Does not seem to be required for complex deadenylase function (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJG9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0030014 CCR4-NOT complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006417 regulation of translation;GO:0031047 regulatory ncRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CWN7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R395-1", "uniprot_id": [ { "id": "COMD5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R395", "type": "external" } ], "mass": 24493.0, "length": 224, "protein_name": "COMM domain-containing protein 5", "gene_name": "Commd5", "organism": "Mouse", "refseq_name": "COMM domain-containing protein 5", "refseq_ac": [ { "id": "NP_079812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079812", "type": "external" } ], "gene_names_uniprotkb": "Commd5", "gene_names_refseq": "2310065H03Rik; Commd5; D15Ertd81e; Hcarg", "protein_names_uniprotkb": "COMM domain-containing protein 5", "protein_names_refseq": "COMM domain-containing protein 5; hypertension-related, calcium regulated", "tax_id": 10090, "disease": "", "pathway": " (mmu:66398); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11871861;21750661", "class_list": "", "function": "A suggestive localization of mouse Hcarg based on conservation of linkage between human and mouse is on chromosome 15., [RefSeq, PubMed]; Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (By similarity). Negatively regulates cell proliferation (By similarity). Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway (By similarity). Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D6R8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0030858 positive regulation of epithelial cell differentiation;GO:0006351 DNA-templated transcription;GO:0030307 positive regulation of cell growth;GO:0072158 proximal tubule morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R395-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BUG2-1", "uniprot_id": [ { "id": "CNDP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BUG2", "type": "external" } ], "mass": 55090.0, "length": 492, "protein_name": "Beta-Ala-His dipeptidase", "gene_name": "Cndp1", "organism": "Mouse", "refseq_name": "beta-Ala-His dipeptidase", "refseq_ac": [ { "id": "NP_803233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803233", "type": "external" } ], "gene_names_uniprotkb": "Cndp1; Cn1", "gene_names_refseq": "Cn1; Cndp1", "protein_names_uniprotkb": "Beta-Ala-His dipeptidase; 3.4.13.20; CNDP dipeptidase 1; Carnosine dipeptidase 1", "protein_names_refseq": "CNDP dipeptidase 1; beta-Ala-His dipeptidase; carnosinase 1; carnosine dipeptidase 1 (metallopeptidase M20 family)", "tax_id": 10090, "disease": "glomerulonephritis (Disease Ontology:DOID:2921)", "pathway": " (mmu:338403)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12473676;21750661;24891507;31587987", "class_list": "", "function": "Catalyzes the peptide bond hydrolysis in Xaa-His dipeptides, displaying the highest activity toward carnosine (beta-alanyl-L-histidine)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80XP5", "ec_number_list": [ { "id": "3.4.13.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.20", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004180 carboxypeptidase activity;GO:0070573 metallodipeptidase activity;GO:0016805 dipeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0051246 regulation of protein metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BUG2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR55-1", "uniprot_id": [ { "id": "CP087_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR55", "type": "external" } ], "mass": 17829.0, "length": 154, "protein_name": "UPF0547 protein C16orf87 homolog", "gene_name": "4921524J17Rik", "organism": "Mouse", "refseq_name": "UPF0547 protein C16orf87 homolog", "refseq_ac": [ { "id": "NP_079998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079998", "type": "external" } ], "gene_names_uniprotkb": "4921524J17Rik", "gene_names_refseq": "4921524J17Rik", "protein_names_uniprotkb": "UPF0547 protein C16orf87 homolog", "protein_names_refseq": "UPF0547 protein C16orf87 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66714)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;30084848;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CR55-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H6Q4-1", "uniprot_id": [ { "id": "TKTI1_MOUSE", "url": "https://www.uniprot.org/uniprot/A6H6Q4", "type": "external" } ], "mass": 23954.0, "length": 206, "protein_name": "Tektin bundle-interacting protein 1", "gene_name": "Tektip1", "organism": "Mouse", "refseq_name": "tektin bundle-interacting protein 1", "refseq_ac": [ { "id": "NP_001014836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014836", "type": "external" } ], "gene_names_uniprotkb": "Tektip1; 4930404N11Rik", "gene_names_refseq": "2210409H10Rik; 4930404N11Rik; 5730551K18Rik; Tektip1", "protein_names_uniprotkb": "Tektin bundle-interacting protein 1", "protein_names_refseq": "tektin bundle-interacting protein 1; uncharacterized protein C19orf71 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:432479)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;37295417;37865089;37989994", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:37295417, PubMed:37865089, PubMed:37989994). Located at the center of the tektin bundle where may function to recruit tektins or stabilize the bundle (PubMed:37295417, PubMed:37865089, PubMed:37989994)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EI87;Q9D5N6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A6H6Q4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6VVW9-1", "uniprot_id": [ { "id": "CP2R1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6VVW9", "type": "external" } ], "mass": 57313.0, "length": 501, "protein_name": "Vitamin D 25-hydroxylase", "gene_name": "Cyp2r1", "organism": "Mouse", "refseq_name": "vitamin D 25-hydroxylase", "refseq_ac": [ { "id": "NP_796356", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796356", "type": "external" } ], "gene_names_uniprotkb": "Cyp2r1", "gene_names_refseq": "Cyp2r1", "protein_names_uniprotkb": "Vitamin D 25-hydroxylase; 1.14.14.24; Cytochrome P450 2R1", "protein_names_refseq": "cytochrome P450, 2r1; vitamin D 25-hydroxylase", "tax_id": 10090, "disease": "vitamin D-dependent rickets type 1B (Disease Ontology:DOID:0080887); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); gestational diabetes (Disease Ontology:DOID:11714); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); brain infarction (Disease Ontology:DOID:3454); coronary stenosis (Disease Ontology:DOID:4248); myocardial infarction (Disease Ontology:DOID:5844); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:244209); (R-MMU-196791); (R-MMU-211916)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12867411;21750661;22592802;24019477;27904043;30084848;30790351;34428180;35524739", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in activation of vitamin D precursors (PubMed:12867411, PubMed:24019477). Catalyzes hydroxylation at C-25 of both forms of vitamin D, vitamin D(2) and D(3) (calciol). Can metabolize vitamin D analogs/prodrugs 1alpha-hydroxyvitamin D(2) (doxercalciferol) and 1alpha-hydroxyvitamin D(3) (alfacalcidol) forming 25-hydroxy derivatives. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity) (PubMed:12867411, PubMed:24019477)., [UniProtKB, UniProtKB, PubMed, PubMed]; CYP2R1 is a strong candidate for the microsomal vitamin D 25-hydroxylase., [RefSeq, PubMed]; CYP2R1 is the major enzyme responsible for 25-hydroxylation of vitamin D., [RefSeq, PubMed]; Data show that the absence of either of the two key hydroxylases, vitamin D 25-hydroxylase (CYP2R1) or vitamin D 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1)neither inhibits nor enhances the development of experimental autoimmune encephalomyelitis (EAE)., [RefSeq, PubMed]; Obesity Decreases Hepatic 25-Hydroxylase Activity Causing Low Serum 25-Hydroxyvitamin D., [RefSeq, PubMed]; Streptozotocin-induced Diabetes Represses Hepatic CYP2R1 Expression but Induces Vitamin D 25-Hydroxylation in Male Mice., [RefSeq, PubMed]; These results suggest that CYP2R1 and CYP26A1 may play a major role in hepatoblast cell differentiation during the development of the liver., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.24", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0042803 protein homodimerization activity;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0030343 vitamin D3 25-hydroxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042359 vitamin D metabolic process;GO:0006805 xenobiotic metabolic process;GO:0010212 response to ionizing radiation;GO:0006082 organic acid metabolic process;GO:0010164 response to cesium ion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6VVW9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUM3-1", "uniprot_id": [ { "id": "COR1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUM3", "type": "external" } ], "mass": 53912.0, "length": 484, "protein_name": "Coronin-1B", "gene_name": "Coro1b", "organism": "Mouse", "refseq_name": "coronin-1B", "refseq_ac": [ { "id": "NP_035908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035908", "type": "external" } ], "gene_names_uniprotkb": "Coro1b", "gene_names_refseq": "Coro1b", "protein_names_uniprotkb": "Coronin-1B; Coronin-2", "protein_names_refseq": "coronin 1b; coronin-1B; coronin-2", "tax_id": 10090, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (mmu:23789)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "16027158;21750661;21844203;22517741;22645316;24081143;25995115;26740625;34428180;35657370;36288343;36852467;37507081;40885482;9778037", "class_list": "", "function": "Cor1B, Cof1 and AIP1 work in concert through a temporally ordered pathway to induce highly efficient severing and disassembly of actin filaments. Publication Status: Online-Only, [RefSeq, PubMed]; Coro1B and Coro1C regulate lamellipodia dynamics and cell motility by tuning branched actin turnover., [RefSeq, PubMed]; Differential regulation of mast cell degranulation versus cytokine secretion by the actin regulatory proteins Coronin1a and Coronin1b., [RefSeq, PubMed]; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UEB1;Q9CVA2", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0044877 protein-containing complex binding;GO:0008092 cytoskeletal protein binding;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0016477 cell migration;GO:0035556 intracellular signal transduction;GO:0030036 actin cytoskeleton organization;GO:0051017 actin filament bundle assembly", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9WUM3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68500-1", "uniprot_id": [ { "id": "CNTN5_MOUSE", "url": "https://www.uniprot.org/uniprot/P68500", "type": "external" } ], "mass": 120746.0, "length": 1098, "protein_name": "Contactin-5", "gene_name": "Cntn5", "organism": "Mouse", "refseq_name": "contactin-5 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001164258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164258", "type": "external" } ], "gene_names_uniprotkb": "Cntn5", "gene_names_refseq": "6720426O10Rik; A830025P08Rik; Cntn5; Gm507; NB-2", "protein_names_uniprotkb": "Contactin-5; Neural recognition molecule NB-2", "protein_names_refseq": "contactin-5 isoform 1 precursor; neural recognition molecule NB-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:244682); (R-MMU-163125)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12653969;19818338;20133774;21750661;22285261;29264679;30899004", "class_list": "", "function": "Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons (By similarity). Involved in neuronal activity in the auditory system., [UniProtKB, PubMed]; Findings demonstrated that NB-2 interacts with APLP and that both NB-2 and APLP1 are localized at presynaptic sites, suggesting that NB-2 associates with APLP1 in a cis manner on the presynaptic membrane, [RefSeq, PubMed]; NB-2 deficiency causes a deficit in synapse formation and then induces apoptosis in MNTB and VCN neurons, affecting auditory brainstem function, [RefSeq, PubMed]; These findings link Cntn5 deficiency to obesity and hypertension, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "E0CYC2", "ec_number_list": [], "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0045202 synapse;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0099054 presynapse assembly;GO:0050808 synapse organization;GO:0007605 sensory perception of sound;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P68500-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35084-1", "uniprot_id": [ { "id": "CP27B_MOUSE", "url": "https://www.uniprot.org/uniprot/O35084", "type": "external" } ], "mass": 56225.0, "length": 507, "protein_name": "25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial", "gene_name": "Cyp27b1", "organism": "Mouse", "refseq_name": "25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial", "refseq_ac": [ { "id": "NP_034139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034139", "type": "external" } ], "gene_names_uniprotkb": "Cyp27b1; Cyp27b; Cyp40", "gene_names_refseq": "Cp2b; Cyp1; Cyp27b1; Cyp27b; Cyp40; P450c1; Pddr; Vdd1; VddrI; Vddr; Vdr", "protein_names_uniprotkb": "25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; 1.14.15.18; 25-OHD-1 alpha-hydroxylase; 25-hydroxyvitamin D(3) 1-alpha-hydroxylase; Calcidiol 1-monooxygenase; Cytochrome P450 subfamily XXVIIB polypeptide 1; Cytochrome P450C1 alpha; Cytochrome P450VD1-alpha; Cytochrome p450 27B1; VD3 1A hydroxylase", "protein_names_refseq": "1alpha(OH)ase; 25(OH)D 1alpha-hydroxylase; 25-OHD-1 alpha-hydroxylase; 25-hydroxyvitamin D(3) 1-alpha-hydroxylase; 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D3 1-alpha-hydroxylase) (VD3 1A hydroxylase) (P450C1 alpha) (P450VD1-alpha); 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; 25-hydroxyvitamin D3 1alpha-hydroxylase; P450VD1alpha; VD3 1A hydroxylase; calcidiol 1-monooxygenase; cytochrome P450 subfamily XXVIIB polypeptide 1; cytochrome P450, 27b1; cytochrome P450, 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase); cytochrome P450C1 alpha; cytochrome P450VD1-alpha; cytochrome p450 27B1", "tax_id": 10090, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815); vitamin D-dependent rickets type 1A (Disease Ontology:DOID:0080886); pre-eclampsia (Disease Ontology:DOID:10591); rickets (Disease Ontology:DOID:10609); gestational diabetes (Disease Ontology:DOID:11714); alcohol use disorder (Disease Ontology:DOID:1574); hepatitis B (Disease Ontology:DOID:2043); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); Wilson disease (Disease Ontology:DOID:893); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:13115); (R-MMU-196791); (R-MMU-211916)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10092858;11149489;15972816;21750661;9295274", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in vitamin D metabolism and in calcium and phosphorus homeostasis. Catalyzes the rate-limiting step in the activation of vitamin D in the kidney, namely the hydroxylation of 25-hydroxyvitamin D3/calcidiol at the C1-alpha position to form the hormonally active form of vitamin D3, 1alpha,25-dihydroxyvitamin D3/calcitriol that acts via the vitamin D receptor (VDR) (PubMed:10092858, PubMed:15972816). Has 1-alpha-hydroxylase activity on vitamin D intermediates of the CYP24A1-mediated inactivation pathway. Converts 24R,25-dihydroxyvitamin D3/secalciferol to 1-alpha,24,25-trihydroxyvitamin D3, an active ligand of VDR. Also active on 25-hydroxyvitamin D2 (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin (PubMed:10092858, PubMed:15972816)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.15.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.18", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004498 calcidiol 1-monooxygenase activity;GO:0062185 secalciferol 1-monooxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0042359 vitamin D metabolic process;GO:0042369 vitamin D catabolic process;GO:0008285 negative regulation of cell population proliferation;GO:0032496 response to lipopolysaccharide;GO:0006816 calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O35084-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1F6-1", "uniprot_id": [ { "id": "CNMD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1F6", "type": "external" } ], "mass": 37225.0, "length": 334, "protein_name": "Leukocyte cell-derived chemotaxin 1", "gene_name": "Cnmd", "organism": "Mouse", "refseq_name": "leukocyte cell-derived chemotaxin 1 isoform 1", "refseq_ac": [ { "id": "NP_001297584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297584", "type": "external" } ], "gene_names_uniprotkb": "Cnmd; Chmd; Chmi; Lect1", "gene_names_refseq": "Bricd3; ChM-I; Chmd; Cnmd; Lect1", "protein_names_uniprotkb": "Leukocyte cell-derived chemotaxin 1; ChM-I; Chondromodulin-I; Chondromodulin", "protein_names_refseq": "Chondromodulin 1; chondromodulin-1; chondromodulin-I; leukocyte cell derived chemotaxin 1; leukocyte cell-derived chemotaxin 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:16840)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16980969;21750661;36795722", "class_list": "", "function": "Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development (By similarity). Inhibits in vitro tube formation and mobilization of endothelial cells (By similarity). Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Chondromodulin is necessary for cartilage callus distraction in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80UX1;Q9CXU5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0012505 endomembrane system", "go_biological_process": "GO:0001937 negative regulation of endothelial cell proliferation;GO:0016525 negative regulation of angiogenesis;GO:0051216 cartilage development;GO:0001886 endothelial cell morphogenesis;GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z1F6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "H3BKT1-1", "uniprot_id": [ { "id": "CS084_MOUSE", "url": "https://www.uniprot.org/uniprot/H3BKT1", "type": "external" } ], "mass": 19979.0, "length": 185, "protein_name": "piRNA-mediated silencing protein C19orf84 homolog", "gene_name": "Gm52993", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm52993; Gm38999", "gene_names_refseq": "", "protein_names_uniprotkb": "piRNA-mediated silencing protein C19orf84 homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "38359823", "class_list": "", "function": "Protein adapter involved in piRNA-directed transposon methylation by connecting PIWIL4-piRNA and DNA methylation machineries (PubMed:38359823). The PIWIL4-piRNA pathway plays a central role during spermatogenesis by directing transposon DNA methylation and silencing, thereby preventing their mobilization, which is essential for the germline integrity (PubMed:38359823)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0010526 transposable element silencing;GO:0141196 transposable element silencing by piRNA-mediated DNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "H3BKT1-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZS0-1", "uniprot_id": [ { "id": "CO4A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZS0", "type": "external" } ], "mass": 161726.0, "length": 1669, "protein_name": "Collagen alpha-3(IV) chain", "gene_name": "Col4a3", "organism": "Mouse", "refseq_name": "collagen alpha-3(IV) chain precursor", "refseq_ac": [ { "id": "NP_031760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031760", "type": "external" } ], "gene_names_uniprotkb": "Col4a3", "gene_names_refseq": "Col4a3; [a]3(IV); alpha3(IV)", "protein_names_uniprotkb": "Collagen alpha-3(IV) chain", "protein_names_refseq": "collagen alpha-3(IV) chain precursor; collagen alpha-3(IV) chain; collagen type IV alpha3 chain; procollagen, type IV, alpha 3; tumstatin", "tax_id": 10090, "disease": "Alport syndrome 3A (Disease Ontology:DOID:0110032); Alport syndrome 2 (Disease Ontology:DOID:0110033); benign familial hematuria (Disease Ontology:DOID:0111365); Alport syndrome (Disease Ontology:DOID:10983); glomerulonephritis (Disease Ontology:DOID:2921); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:12828)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10534397;12842087;14633121;16877525;21750661;23411782;25428506;25769923;31599954;32444356;7962065;8956999", "class_list": "", "function": "Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms., [UniProtKB, PubMed, UniProtKB, PubMed]; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 2, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q61430;Q61435;Q8CCD6", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0030020 extracellular matrix structural constituent conferring tensile strength;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0005587 collagen type IV trimer;GO:0005581 collagen trimer", "go_biological_process": "GO:0007155 cell adhesion;GO:0007166 cell surface receptor signaling pathway;GO:0030198 extracellular matrix organization;GO:0030199 collagen fibril organization;GO:0016525 negative regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9QZS0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08792-1", "uniprot_id": [ { "id": "COE2_MOUSE", "url": "https://www.uniprot.org/uniprot/O08792", "type": "external" } ], "mass": 62606.0, "length": 575, "protein_name": "Transcription factor COE2", "gene_name": "Ebf2", "organism": "Mouse", "refseq_name": "transcription factor COE2", "refseq_ac": [ { "id": "NP_001263316", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263316", "type": "external" } ], "gene_names_uniprotkb": "Ebf2; Coe2; Mmot1", "gene_names_refseq": "D14Ggc1e; EBF-2; Ebf2; Mmot1; O/E-3; OE-3", "protein_names_uniprotkb": "Transcription factor COE2; EBF-2; Early B-cell factor 2; MET-mesencephalon-olfactory TF1; MET-mesencephalon-olfactory transcription factor 1; Metencephalon-mesencephalon-olfactory transcription factor 1; O/E-3; OE-3; Olf-1/EBF-like 3", "protein_names_refseq": "MET-mesencephalon-olfactory TF1; MET-mesencephalon-olfactory transcription factor 1; Olf-1/EBF-like 3; metencephalon-mesencephalon-olfactory transcription factor 1; transcription factor COE2", "tax_id": 10090, "disease": "", "pathway": " (mmu:13592)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16326388;27923061;9151732;9211912;9389446", "class_list": "", "function": "Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q543D5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050873 brown fat cell differentiation;GO:0060612 adipose tissue development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O08792-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55029-1", "uniprot_id": [ { "id": "COPB2_MOUSE", "url": "https://www.uniprot.org/uniprot/O55029", "type": "external" } ], "mass": 102449.0, "length": 905, "protein_name": "Coatomer subunit beta'", "gene_name": "Copb2", "organism": "Mouse", "refseq_name": "coatomer subunit beta'", "refseq_ac": [ { "id": "NP_056642", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056642", "type": "external" } ], "gene_names_uniprotkb": "Copb2", "gene_names_refseq": "Copb2", "protein_names_uniprotkb": "Coatomer subunit beta'; Beta'-COP; Beta'-coat protein; p102", "protein_names_refseq": "beta'-COP; beta'-coat protein; coatomer protein complex, subunit beta 2 (beta prime); coatomer subunit beta'; p102", "tax_id": 10090, "disease": "primary autosomal recessive microcephaly 19 (Disease Ontology:DOID:0070281); microcephaly (Disease Ontology:DOID:10907)", "pathway": " (mmu:50797); (R-MMU-6807878); (R-MMU-6811434)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "17360540;26495903;27802388;29036432;31219806;32152506;34428180;34450031;36210013;37296621;37453647;37828378", "class_list": "", "function": "Beta-COP Suppresses the Surface Expression of the TREK2. Publication Status: Online-Only, [RefSeq, PubMed]; COPB2 loss of function causes a coatopathy with osteoporosis and developmental delay., [RefSeq, PubMed]; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity)., [UniProtKB, UniProtKB]; This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5Z9", "ec_number_list": [], "go_molecular_function": "GO:0005080 protein kinase C binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030126 COPI vesicle coat", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O55029-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00186-1", "uniprot_id": [ { "id": "CP1A2_MOUSE", "url": "https://www.uniprot.org/uniprot/P00186", "type": "external" } ], "mass": 58184.0, "length": 513, "protein_name": "Cytochrome P450 1A2", "gene_name": "Cyp1a2", "organism": "Mouse", "refseq_name": "cytochrome P450 1A2", "refseq_ac": [ { "id": "NP_034123", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034123", "type": "external" } ], "gene_names_uniprotkb": "Cyp1a2; Cyp1a-2", "gene_names_refseq": "CP12; CYPIA2; Cyp1a2; P450-3", "protein_names_uniprotkb": "Cytochrome P450 1A2; 1.14.14.1; 4.2.1.152; CYPIA2; Cholesterol 25-hydroxylase; Cytochrome P450-P2; Cytochrome P450-P3; Hydroperoxy icosatetraenoate dehydratase", "protein_names_refseq": "cholesterol 25-hydroxylase; cytochrome P450 1A2; cytochrome P450 family 1 subfamily a polypeptide 1; cytochrome P450, 1a2, aromatic compound inducible; cytochrome P450-P2; cytochrome P450-P3; hydroperoxy icosatetraenoate dehydratase", "tax_id": 10090, "disease": "endometrial cancer (Disease Ontology:DOID:1380); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); porphyria cutanea tarda (Disease Ontology:DOID:3132); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:13077); (R-MMU-156581); (R-MMU-211957); (R-MMU-2142670); (R-MMU-2142816); (R-MMU-5423646); (R-MMU-9018681); (R-MMU-9027307)", "pathway_count": 8, "publication_count": 8, "publication_id_list": "2425809;34428180;3718958;3755821;3988744;6324134;6547952;6548461", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer. Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin. Metabolizes caffeine via N3-demethylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9QWJ4", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "5.3.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.4", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.14.14", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.14", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "1.14.14.80", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.80", "type": "external" }, { "id": "1.14.14.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.94", "type": "external" }, { "id": "5.4.4.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.4.7", "type": "external" } ], "go_molecular_function": "GO:0101020 estrogen 16-alpha-hydroxylase activity;GO:0005506 iron ion binding;GO:0019899 enzyme binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0016098 monoterpenoid metabolic process;GO:0008203 cholesterol metabolic process;GO:0030324 lung development;GO:0042572 retinol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P00186-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08122-1", "uniprot_id": [ { "id": "CO4A2_MOUSE", "url": "https://www.uniprot.org/uniprot/P08122", "type": "external" } ], "mass": 167325.0, "length": 1707, "protein_name": "Collagen alpha-2(IV) chain", "gene_name": "Col4a2", "organism": "Mouse", "refseq_name": "collagen alpha-2(IV) chain precursor", "refseq_ac": [ { "id": "NP_034062", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034062", "type": "external" } ], "gene_names_uniprotkb": "Col4a2", "gene_names_refseq": "Col4a-2; Col4a2", "protein_names_uniprotkb": "Collagen alpha-2(IV) chain", "protein_names_refseq": "canstatin; collagen alpha-2(IV) chain precursor; collagen alpha-2(IV) chain; procollagen, type IV, alpha 2", "tax_id": 10090, "disease": "porencephaly (Disease Ontology:DOID:0060263); autosomal recessive brain small vessel disease 2B (Disease Ontology:DOID:0061233); autosomal dominant brain small vessel disease 2A (Disease Ontology:DOID:0112314); severe pre-eclampsia (Disease Ontology:DOID:13129); uterine fibroid (Disease Ontology:DOID:13223); atherosclerosis (Disease Ontology:DOID:1936); myopathy (Disease Ontology:DOID:423); collagen disease (Disease Ontology:DOID:854)", "pathway": " (mmu:12827); (R-MMU-1442490); (R-MMU-1566977); (R-MMU-1650814); (R-MMU-186797); (R-MMU-2022090); (R-MMU-216083); (R-MMU-2243919); (R-MMU-3000157); (R-MMU-3000171); (R-MMU-419037)", "pathway_count": 11, "publication_count": 13, "publication_id_list": "15592653;17324935;2703491;3011432;3198626;3200851;32571911;34428180;3597383;3758345;3780963;3839908;39216230", "class_list": "", "function": "Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins (By similarity)., [UniProtKB]; Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhage., [RefSeq, PubMed]; This gene encodes the alpha-2 subunit of the type IV collagens, an essential component of basement membranes. The encoded protein forms a triple helical heterotrimer comprised of alpha-1 and alpha-2 subunits that assembles into a type IV collagen network. Canstatin, a peptide derived fom the C-terminus of the collagen chain, is a matrikine that has been shown to inhibit angiogenesis. Homozygous knockout mice for this gene exhibit impaired basement membrane integrity and embryonic lethality. This gene shares a bi-directional promoter with a related gene on chromosome 8. [provided by RefSeq, Nov 2015]., [RefSeq]; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen., [UniProtKB, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 2, "predicted_o_glycosites": 8, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q3B7C2;Q3TPV9;Q61375;Q66JS5;Q6RCT6;Q6RCT7;Q6U9X1;Q8BPI9;Q8BPK3;Q91VI3", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0005587 collagen type IV trimer", "go_biological_process": "GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0030198 extracellular matrix organization;GO:0030199 collagen fibril organization;GO:0014823 response to activity", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P08122-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15392-1", "uniprot_id": [ { "id": "CP2A4_MOUSE", "url": "https://www.uniprot.org/uniprot/P15392", "type": "external" } ], "mass": 56782.0, "length": 494, "protein_name": "Cytochrome P450 2A4", "gene_name": "Cyp2a4", "organism": "Mouse", "refseq_name": "cytochrome P450 2A4", "refseq_ac": [ { "id": "NP_034127", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034127", "type": "external" } ], "gene_names_uniprotkb": "Cyp2a4; Cyp2a-4", "gene_names_refseq": "Cyp15a1; Cyp2a4; D7Ucla4", "protein_names_uniprotkb": "Cytochrome P450 2A4; 1.14.14.1; CYPIIA4; Cytochrome P450-15-alpha; Cytochrome P450-IIA3.1; Testosterone 15-alpha-hydroxylase", "protein_names_refseq": "CYPIIA4; cytochrome P450 2A4; cytochrome P450, 2a4; cytochrome P450-15-alpha; cytochrome P450-IIA3.1; testosterone 15-alpha-hydroxylase; testosterone 15alpha-hydroxylase", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); warfarin resistance (Disease Ontology:DOID:0080665); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (mmu:13086); (R-MMU-211935); (R-MMU-211981); (R-MMU-211999); (R-MMU-5423646)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "10490589;2703500;2733794;30059200;3346244;34428180", "class_list": "", "function": "Highly active in the 15-alpha-hydroxylation of testosterone. Also active in the 15-alpha-hydroxylation of progesterone and androstenedione. Little or no activity on corticosterone, pregnenolone, dehydroepiandrosterone, estradiol or estriol., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q91XG2", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0019899 enzyme binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008392 arachidonate epoxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0035634 response to stilbenoid;GO:0019373 epoxygenase P450 pathway;GO:0009804 coumarin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P15392-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51642-1", "uniprot_id": [ { "id": "CNTF_MOUSE", "url": "https://www.uniprot.org/uniprot/P51642", "type": "external" } ], "mass": 22587.0, "length": 198, "protein_name": "Ciliary neurotrophic factor", "gene_name": "Cntf", "organism": "Mouse", "refseq_name": "ciliary neurotrophic factor", "refseq_ac": [ { "id": "NP_740756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_740756", "type": "external" } ], "gene_names_uniprotkb": "Cntf", "gene_names_refseq": "Cntf", "protein_names_uniprotkb": "Ciliary neurotrophic factor; CNTF", "protein_names_refseq": "ciliary neurotrophic factor", "tax_id": 10090, "disease": "keratoconus (Disease Ontology:DOID:10126); retinitis pigmentosa (Disease Ontology:DOID:10584); Huntington's disease (Disease Ontology:DOID:12858); disease of mental health (Disease Ontology:DOID:150); glaucoma (Disease Ontology:DOID:1686); multiple sclerosis (Disease Ontology:DOID:2377); hyperglycemia (Disease Ontology:DOID:4195); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12803); (R-MMU-6788467)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "35820727;7835706", "class_list": "", "function": "Functions as a cytokine through the ciliary neurotrophic factor receptor (CNTFR) complex. The CNTFR complex indeed consists of the membrane-anchored non-signaling receptor CNTFR and the two signaling receptor subunits IL6ST/gp130 and LIFR that transduce the signal into the cell. Functionally, promotes neuronal survival, supports differentiation of various neuronal and non-neuronal cells, and importantly regulates oligodendrocyte progenitor proliferation. Mechanistically, ligand binding to the CNTFR induces dimerization of the IL6ST/gp130 and LIFR, which activates JAK tyrosine kinases (JAK1 or JAK2 and to lesser extent TYK2) bound to their intracellular domains. These kinases subsequently phosphorylate IL6ST/gp130 and LIFR. The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activators of transcription (STAT3 and to lesser extent STAT1). Can also signal via trans-signaling using soluble forms of CNTFR (By similarity). Seems to prevent the degeneration of motor axons after axotomy (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes, and it may be involved in reducing tissue destruction during inflammatory attacks. A read-through transcript variant composed of Zfp91 and Cntf sequences has been identified, but it is thought to be non-coding. Read-through transcription of Zfp91 and Cntf has been observed in both human and mouse. [provided by RefSeq, Aug 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0005138 interleukin-6 receptor binding;GO:0005127 ciliary neurotrophic factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0032838 plasma membrane bounded cell projection cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0048680 positive regulation of axon regeneration;GO:0046533 negative regulation of photoreceptor cell differentiation;GO:0046668 regulation of retinal cell programmed cell death;GO:0070120 ciliary neurotrophic factor-mediated signaling pathway;GO:0070446 negative regulation of oligodendrocyte progenitor proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P51642-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00941-1", "uniprot_id": [ { "id": "CSF2R_MOUSE", "url": "https://www.uniprot.org/uniprot/Q00941", "type": "external" } ], "mass": 41769.0, "length": 388, "protein_name": "Granulocyte-macrophage colony-stimulating factor receptor subunit alpha", "gene_name": "Csf2ra", "organism": "Mouse", "refseq_name": "granulocyte-macrophage colony-stimulating factor receptor subunit alpha precursor", "refseq_ac": [ { "id": "NP_034100", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034100", "type": "external" } ], "gene_names_uniprotkb": "Csf2ra; Csfgmra", "gene_names_refseq": "CD116; Csf2ra; Csfgmra; GM-CSF-Ra; GM-CSFR", "protein_names_uniprotkb": "Granulocyte-macrophage colony-stimulating factor receptor subunit alpha; GM-CSF-R-alpha; GMCSFR-alpha; GMR-alpha", "protein_names_refseq": "GM-CSF-R-alpha; GM-CSFRalpha; GMCSFR-alpha; GMR-alpha; colony stimulating factor 2 receptor alpha chain; granulocyte-macrophage colony-stimulating factor receptor subunit alpha precursor; granulocyte-macrophage colony-stimulating factor receptor subunit alpha", "tax_id": 10090, "disease": "pulmonary alveolar proteinosis (Disease Ontology:DOID:12120)", "pathway": " (mmu:12982)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1533931;17694571;18250455", "class_list": "", "function": "Contrary to isoform 1, does not trigger cell proliferation in response to GM-CSF., [UniProtKB, PubMed]; Low affinity receptor for granulocyte-macrophage colony-stimulating factor (GM-CSF). Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells., [UniProtKB, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A9P557;A9P558;E9QJX0", "ec_number_list": [], "go_molecular_function": "GO:0004896 cytokine receptor activity;GO:0051916 granulocyte colony-stimulating factor binding;GO:0004902 granulocyte colony-stimulating factor receptor activity", "go_cellular_component": "GO:0030526 granulocyte macrophage colony-stimulating factor receptor complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus;GO:0007259 cell surface receptor signaling pathway via JAK-STAT;GO:0070665 positive regulation of leukocyte proliferation;GO:0038157 granulocyte-macrophage colony-stimulating factor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q00941-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VG49-1", "uniprot_id": [ { "id": "CO061_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0VG49", "type": "external" } ], "mass": 17987.0, "length": 157, "protein_name": "Uncharacterized protein C15orf61 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C15orf61 homolog precursor", "refseq_ac": [ { "id": "NP_081366", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081366", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "2300009A05Rik", "protein_names_uniprotkb": "Uncharacterized protein C15orf61 homolog", "protein_names_refseq": "uncharacterized protein C15orf61 homolog precursor; uncharacterized protein C15orf61 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:69478)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TYQ8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VG49-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U2J5-1", "uniprot_id": [ { "id": "CMKMT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U2J5", "type": "external" } ], "mass": 35887.0, "length": 323, "protein_name": "Calmodulin-lysine N-methyltransferase", "gene_name": "Camkmt", "organism": "Mouse", "refseq_name": "calmodulin-lysine N-methyltransferase isoform 1", "refseq_ac": [ { "id": "NP_082852", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082852", "type": "external" } ], "gene_names_uniprotkb": "Camkmt; Clnmt", "gene_names_refseq": "1700106N22Rik; CLNMT; CaM KMT; Camkmt", "protein_names_uniprotkb": "Calmodulin-lysine N-methyltransferase; 2.1.1.60; CLNMT; CaM KMT", "protein_names_refseq": "calmodulin-lysine N-methyltransferase isoform 1", "tax_id": 10090, "disease": "hypotonia-cystinuria syndrome (Disease Ontology:DOID:0060858)", "pathway": " (mmu:73582); (R-MMU-2514859); (R-MMU-8876725)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "23285036;26247364;30084848;30779550;31219806", "class_list": "", "function": "CaM methylation appears to have a role in growth, muscle strength, somatosensory development and brain function. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the trimethylation of 'Lys-116' in calmodulin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D9C5", "ec_number_list": [ { "id": "2.1.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.60", "type": "external" } ], "go_molecular_function": "GO:0031072 heat shock protein binding;GO:0018025 calmodulin-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0018022 peptidyl-lysine methylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3U2J5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UW12-1", "uniprot_id": [ { "id": "CNGA4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UW12", "type": "external" } ], "mass": 65835.0, "length": 575, "protein_name": "Cyclic nucleotide-gated channel alpha-4", "gene_name": "Cnga4", "organism": "Mouse", "refseq_name": "cyclic nucleotide-gated channel alpha-4", "refseq_ac": [ { "id": "NP_001028489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028489", "type": "external" } ], "gene_names_uniprotkb": "Cnga4", "gene_names_refseq": "Cnga4; OCNC2", "protein_names_uniprotkb": "Cyclic nucleotide-gated channel alpha-4; CNG channel alpha-4; CNGa4; OCNC2; Olfactory cyclic nucleotide-gated channel subunit 2", "protein_names_refseq": "CNG channel alpha-4; CNG-4; CNG4; cyclic nucleotide gated cation channel; cyclic nucleotide-gated cation channel alpha-4; cyclic nucleotide-gated channel alpha-4; olfactory cyclic nucleotide-gated channel subunit 2; olfactory cyclic nucleotide-gated channel", "tax_id": 10090, "disease": "", "pathway": " (mmu:233649); (R-MMU-5620916)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11739959;11764791;12649326;35820727", "class_list": "", "function": "Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations (By similarity) (PubMed:11739959, PubMed:12649326). May conduct nitric oxide-gated Ca(2+) currents relevant to neurons of vomeronasal organ, a system involved in the perception of pheromones (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08EL1", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0044877 protein-containing complex binding;GO:0005223 intracellularly cGMP-activated cation channel activity;GO:0005222 intracellularly cAMP-activated cation channel activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043204 perikaryon;GO:0017071 intracellular cyclic nucleotide activated cation channel complex;GO:0098804 non-motile cilium membrane", "go_biological_process": "GO:0006816 calcium ion transport;GO:0098655 monoatomic cation transmembrane transport;GO:0006813 potassium ion transport;GO:0007608 sensory perception of smell;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3UW12-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V4B5-1", "uniprot_id": [ { "id": "COMD6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V4B5", "type": "external" } ], "mass": 9795.0, "length": 87, "protein_name": "COMM domain-containing protein 6", "gene_name": "Commd6", "organism": "Mouse", "refseq_name": "COMM domain-containing protein 6 isoform 1", "refseq_ac": [ { "id": "NP_001028304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028304", "type": "external" } ], "gene_names_uniprotkb": "Commd6", "gene_names_refseq": "1110059J08Rik; 1700063H17Rik; Commd6", "protein_names_uniprotkb": "COMM domain-containing protein 6", "protein_names_refseq": "COMM domain-containing protein 6 isoform 1; COMM domain-containing protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:66200); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (By similarity). Down-regulates activation of NF-kappa-B (By similarity). Inhibits TNF-induced NFKB1 activation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051059 NF-kappaB binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3V4B5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64441-1", "uniprot_id": [ { "id": "CP24A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64441", "type": "external" } ], "mass": 59453.0, "length": 514, "protein_name": "1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial", "gene_name": "Cyp24a1", "organism": "Mouse", "refseq_name": "1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_034126", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034126", "type": "external" } ], "gene_names_uniprotkb": "Cyp24a1; Cyp-24; Cyp24", "gene_names_refseq": "24-OHase; CP24; Cyp24a1; Cyp24", "protein_names_uniprotkb": "1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; 1.14.15.16; 24-OHase; Cytochrome P450 24A1; Cytochrome P450-CC24; Vitamin D(3) 24-hydroxylase", "protein_names_refseq": "1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial precursor; 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; 25-hydroxyvitamin D-24-hydroxylase; cytochrome P450 24A1; cytochrome P450, 24a1; cytochrome P450-CC24; vitamin D(3) 24-hydroxylase", "tax_id": 10090, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); infantile hypercalcemia 1 (Disease Ontology:DOID:0061136); pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714); lung cancer (Disease Ontology:DOID:1324); rectum cancer (Disease Ontology:DOID:1993); colon cancer (Disease Ontology:DOID:219); colon adenocarcinoma (Disease Ontology:DOID:234); asthma (Disease Ontology:DOID:2841); breast carcinoma (Disease Ontology:DOID:3459); ovary adenocarcinoma (Disease Ontology:DOID:3713); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); esophagus adenocarcinoma (Disease Ontology:DOID:4914); esophageal cancer (Disease Ontology:DOID:5041); lung small cell carcinoma (Disease Ontology:DOID:5409); ulcerative colitis (Disease Ontology:DOID:8577); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:13081); (R-MMU-196791); (R-MMU-211916)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "14528024;31981799;38167730;39363152;7578252;9165006", "class_list": "", "function": "A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24-oxidation pathway, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)). With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid. Hydroxylates at C-24 or C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S-hydroxycholecalciferol and 20S,23-dihydroxycholecalciferol. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin., [UniProtKB, UniProtKB]; Cell-type differential targeting of SETDB1 prevents aberrant CTCF binding, chromatin looping, and cis-regulatory interactions. Publication Status: Online-Only, [RefSeq, PubMed]; Impact of dietary vitamin D on initiation and progression of oral cancer., [RefSeq, PubMed]; In Vivo Contribution of Cyp24a1 Promoter Vitamin D Response Elements., [RefSeq, PubMed]; The protein encoded by this gene localizes to the mitochondrion, where it degrades calcitriol to calcitetrol. This gene is upregulated by binding of calcitriol to the upstream regulatory region and to a downstream enhancer region, thereby allowing calcitriol to autoregulate its concentration in the cell. The encoded protein may also play a role in calcium homeostasis. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.15.16", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.16", "type": "external" } ], "go_molecular_function": "GO:0008403 25-hydroxycholecalciferol-24-hydroxylase activity;GO:0030342 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0030343 vitamin D3 25-hydroxylase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0042359 vitamin D metabolic process;GO:0042369 vitamin D catabolic process;GO:0001649 osteoblast differentiation;GO:0033280 response to vitamin D;GO:0071305 cellular response to vitamin D", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q64441-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64481-1", "uniprot_id": [ { "id": "CP3AG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64481", "type": "external" } ], "mass": 57870.0, "length": 504, "protein_name": "Cytochrome P450 3A16", "gene_name": "Cyp3a16", "organism": "Mouse", "refseq_name": "cytochrome P450 3A16", "refseq_ac": [ { "id": "NP_031846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031846", "type": "external" } ], "gene_names_uniprotkb": "Cyp3a16; Cyp3a-16", "gene_names_refseq": "Cyp3a16", "protein_names_uniprotkb": "Cytochrome P450 3A16; 1.14.14.1; CYPIIIA16", "protein_names_refseq": "CYPIIIA16; cytochrome P450 3A16; cytochrome P450, 3a16", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); essential hypertension (Disease Ontology:DOID:10825); cholestasis (Disease Ontology:DOID:13580); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); oral submucous fibrosis (Disease Ontology:DOID:5773); end stage renal disease (Disease Ontology:DOID:783); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:13114); (R-MMU-211945); (R-MMU-211958); (R-MMU-211981); (R-MMU-5423646); (R-MMU-9027307); (R-MMU-9749641); (R-MMU-9754706); (R-MMU-9757110)", "pathway_count": 9, "publication_count": 4, "publication_id_list": "19188337;30084848;34428180;7813478", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB]; Dynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QP65", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" } ], "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0101020 estrogen 16-alpha-hydroxylase activity;GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0002933 lipid hydroxylation;GO:0008210 estrogen metabolic process;GO:0042573 retinoic acid metabolic process;GO:0042178 xenobiotic catabolic process;GO:0070989 oxidative demethylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q64481-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6XVG2-1", "uniprot_id": [ { "id": "CP254_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6XVG2", "type": "external" } ], "mass": 55858.0, "length": 490, "protein_name": "Cytochrome P450 2C54", "gene_name": "Cyp2c54", "organism": "Mouse", "refseq_name": "cytochrome P450 2C54", "refseq_ac": [ { "id": "NP_996260", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996260", "type": "external" } ], "gene_names_uniprotkb": "Cyp2c54", "gene_names_refseq": "Cyp2c54; EG404195", "protein_names_uniprotkb": "Cytochrome P450 2C54; 1.14.14.1; CYPIIC54", "protein_names_refseq": "CYPIIC54; cytochrome P450 2C54", "tax_id": 10090, "disease": "renal hypertension (Disease Ontology:DOID:1073); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:404195)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15102943;34428180", "class_list": "", "function": "Metabolizes arachidonic acid mainly to 12-hydroxyeicosatetraenoic acid (HETE)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" } ], "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0071614 linoleic acid epoxygenase activity;GO:0101020 estrogen 16-alpha-hydroxylase activity;GO:0005506 iron ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0002933 lipid hydroxylation;GO:0008210 estrogen metabolic process;GO:0046456 icosanoid biosynthetic process;GO:0043651 linoleic acid metabolic process;GO:0042573 retinoic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6XVG2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH35-1", "uniprot_id": [ { "id": "CO8B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH35", "type": "external" } ], "mass": 66229.0, "length": 589, "protein_name": "Complement component C8 beta chain", "gene_name": "C8b", "organism": "Mouse", "refseq_name": "complement component C8 beta chain isoform 2 precursor", "refseq_ac": [ { "id": "NP_001303600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303600", "type": "external" } ], "gene_names_uniprotkb": "C8b", "gene_names_refseq": "4930439B20Rik; C8b", "protein_names_uniprotkb": "Complement component C8 beta chain; Complement component 8 subunit beta", "protein_names_refseq": "complement component 8, beta subunit; complement component C8 beta chain isoform 2 precursor; complement component C8 beta chain", "tax_id": 10090, "disease": "type II complement component 8 deficiency (Disease Ontology:DOID:0060302); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:110382); (R-MMU-166665); (R-MMU-977606)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;16944957;30084848;34428180", "class_list": "", "function": "Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C8B, together with C8A and C8G, inserts into the target membrane, but does not form pores by itself. During MAC assembly, associates with C5b, C6 and C7 to form the C5b8 intermediate complex that inserts into the target membrane and traverses the bilayer increasing membrane rigidity., [UniProtKB, UniProtKB]; This gene encodes the beta subunit of complement component C8 that participates in the assembly of the complement membrane attack complex. The encoded preproprotein undergoes proteolytic processing to generate the beta subunit, which associates with the alpha and gamma subunits to form a trimeric complement component, C8. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. This gene is located adjacent to the gene encoding the alpha subunit. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 4, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q4VAH1;Q8CHJ5;Q8CHJ6;Q8VC14", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:1902495 transmembrane transporter complex;GO:0005579 membrane attack complex", "go_biological_process": "GO:0031640 killing of cells of another organism;GO:0050778 positive regulation of immune response;GO:0006958 complement activation, classical pathway;GO:0006956 complement activation;GO:0006957 complement activation, alternative pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BH35-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000101.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHB7-1", "uniprot_id": [ { "id": "CP046_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHB7", "type": "external" } ], "mass": 45038.0, "length": 409, "protein_name": "Uncharacterized protein C16orf46 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C16orf46 homolog isoform a", "refseq_ac": [ { "id": "NP_081379", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081379", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "1700030J22Rik", "protein_names_uniprotkb": "Uncharacterized protein C16orf46 homolog", "protein_names_refseq": "uncharacterized protein C16orf46 homolog isoform a; uncharacterized protein C16orf46 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:69528)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q810Q8;Q9D9R4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BHB7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BS40-1", "uniprot_id": [ { "id": "CPTP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BS40", "type": "external" } ], "mass": 24597.0, "length": 216, "protein_name": "Ceramide-1-phosphate transfer protein", "gene_name": "Cptp", "organism": "Mouse", "refseq_name": "ceramide-1-phosphate transfer protein", "refseq_ac": [ { "id": "NP_077792", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077792", "type": "external" } ], "gene_names_uniprotkb": "Cptp; Gltpd1", "gene_names_refseq": "Cptp; Gltpd1", "protein_names_uniprotkb": "Ceramide-1-phosphate transfer protein; CPTP; Glycolipid transfer protein domain-containing protein 1", "protein_names_refseq": "ceramide-1-phosphate transfer protein; glycolipid transfer protein domain containing 1; glycolipid transfer protein domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:79554); (R-MMU-9845576)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;23863933;29164996;34428180", "class_list": "", "function": "Crystal structure of CPTP, [RefSeq, PubMed]; Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles (By similarity). Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis (PubMed:29164996)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ADA2;Q99LU9", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:1902387 ceramide 1-phosphate binding;GO:1902388 ceramide 1-phosphate transfer activity;GO:0008289 lipid binding;GO:0120013 lipid transfer activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032588 trans-Golgi network membrane;GO:0010008 endosome membrane;GO:0005814 centriole", "go_biological_process": "GO:0035627 ceramide transport;GO:0032691 negative regulation of interleukin-1 beta production;GO:0010507 negative regulation of autophagy;GO:1902389 ceramide 1-phosphate transport;GO:0120009 intermembrane lipid transfer", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BS40-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K0C4-1", "uniprot_id": [ { "id": "CP51A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K0C4", "type": "external" } ], "mass": 56776.0, "length": 503, "protein_name": "Lanosterol 14-alpha demethylase", "gene_name": "Cyp51a1", "organism": "Mouse", "refseq_name": "lanosterol 14-alpha demethylase", "refseq_ac": [ { "id": "NP_064394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064394", "type": "external" } ], "gene_names_uniprotkb": "Cyp51a1; Cyp51", "gene_names_refseq": "CYPLI; Cyp51a1; Cyp51; Ldm; P450-14DM; P450LI", "protein_names_uniprotkb": "Lanosterol 14-alpha demethylase; 1.14.14.154; CYP51; CYPLI; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; LDM; Sterol 14-alpha demethylase", "protein_names_refseq": "cytochrome P450 51A1; cytochrome P450, 51; cytochrome P450-14DM; cytochrome P45014DM; cytochrome P450LI; lanosterol 14-alpha demethylase; sterol 14-alpha demethylase", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (mmu:13121); (R-MMU-211976); (R-MMU-6807047)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10653123;10864439;21705796;25605945;28938463;30084848;31219806;31599954;34428180;37828378", "class_list": "", "function": "CYP51 is a mediator of T3 and FSH-induced follicular development., [RefSeq, PubMed]; Sterol 14alpha-demethylase that plays a critical role in the cholesterol biosynthesis pathway, being cholesterol the major sterol component in mammalian membranes as well as a precursor for bile acid and steroid hormone synthesis (PubMed:21705796). Cytochrome P450 monooxygenase that catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of sterols such as lanosterol (lanosta-8,24-dien-3beta-ol) and 24,25-dihydrolanosterol (DHL) in the form of formate, and converts the sterols to 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol and 4,4-dimethyl-8,14-cholestadien-3beta-ol, respectively, which are intermediates of cholesterol biosynthesis (PubMed:21705796). Can also demethylate substrates not intrinsic to mammals, such as eburicol (24-methylene-24,25-dihydrolanosterol), but at a lower rate than DHL (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BSQ7;Q9JIP8;Q9JIY3", "ec_number_list": [ { "id": "1.14.14.154", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.154", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0008398 sterol 14-demethylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0050709 negative regulation of protein secretion;GO:0060282 positive regulation of oocyte development;GO:0007283 spermatogenesis;GO:0010288 response to lead ion;GO:0032868 response to insulin", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K0C4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3P5-1", "uniprot_id": [ { "id": "CNOT6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K3P5", "type": "external" } ], "mass": 63304.0, "length": 557, "protein_name": "CCR4-NOT transcription complex subunit 6", "gene_name": "Cnot6", "organism": "Mouse", "refseq_name": "CCR4-NOT transcription complex subunit 6 isoform 1", "refseq_ac": [ { "id": "NP_001277670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277670", "type": "external" } ], "gene_names_uniprotkb": "Cnot6; Ccr4; Kiaa1194", "gene_names_refseq": "CCR4; Cnot6", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 6; 3.1.13.4; CCR4 carbon catabolite repression 4-like; Carbon catabolite repressor protein 4 homolog; Cytoplasmic deadenylase", "protein_names_refseq": "CCR4-NOT transcription complex subunit 6 isoform 1; carbon catabolite repressor protein 4 homolog; cytoplasmic deadenylase", "tax_id": 10090, "disease": "heart disease (Disease Ontology:DOID:114)", "pathway": " (mmu:104625); (R-MMU-429947); (R-MMU-6804115)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11747467;15314026;22367759;25428506;30084848;31219806;34428180", "class_list": "", "function": "Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors. Mediates cell proliferation and cell survival and prevents cellular senescence., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5NCL3;Q80V15", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.13.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.4", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004532 RNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0030014 CCR4-NOT complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006417 regulation of translation;GO:0008284 positive regulation of cell population proliferation;GO:0035279 miRNA-mediated gene silencing by mRNA destabilization;GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K3P5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K445-1", "uniprot_id": [ { "id": "CLRN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K445", "type": "external" } ], "mass": 25804.0, "length": 232, "protein_name": "Clarin-1", "gene_name": "Clrn1", "organism": "Mouse", "refseq_name": "clarin-1 isoform 1", "refseq_ac": [ { "id": "NP_700433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_700433", "type": "external" } ], "gene_names_uniprotkb": "Clrn1; Ush3a", "gene_names_refseq": "A130002D11Rik; Clrn1; USH3; Ush3a; clarin-1", "protein_names_uniprotkb": "Clarin-1; Usher syndrome type-3 protein homolog", "protein_names_refseq": "Usher syndrome 3A homolog; clarin-1 isoform 1; usher syndrome type-3 protein homolog", "tax_id": 10090, "disease": "Usher syndrome (Disease Ontology:DOID:0050439); retinitis pigmentosa 61 (Disease Ontology:DOID:0110373); Usher syndrome type 3 (Disease Ontology:DOID:0110828); Usher syndrome type 3A (Disease Ontology:DOID:0110841); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:229320)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12080385;17493778;19414487;19423712;29985171", "class_list": "", "function": "A role for clarin-1 in hair cell and photoreceptor cell synapses, as well as a common pathophysiological pathway for different Usher syndromes, [RefSeq, PubMed]; Clarin-1 has a role in the regulation and homeostasis of actin filaments, [RefSeq, PubMed]; Clarin-1 ribozyme induced apoptosis of cochlear hair cells and cells of stria vascularis. Suggest role for apoptosis in progressin of Usher syndrome type 3., [RefSeq, PubMed]; Clrn1 is necessary for hair cell function and associated neural activation., [RefSeq, PubMed]; May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina., [UniProtKB, PubMed]; Results identify clarin-1 as a key organizer of IHC ribbon synapses, and suggest new treatment possibilities for USH3A patients., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8K446", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0045178 basal part of cell;GO:0015630 microtubule cytoskeleton;GO:0005902 microvillus", "go_biological_process": "GO:0007015 actin filament organization;GO:0050885 neuromuscular process controlling balance;GO:0007601 visual perception;GO:0045494 photoreceptor cell maintenance;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K445-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4M5-1", "uniprot_id": [ { "id": "COMD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K4M5", "type": "external" } ], "mass": 20996.0, "length": 188, "protein_name": "COMM domain-containing protein 1", "gene_name": "Commd1", "organism": "Mouse", "refseq_name": "COMM domain-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_653097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653097", "type": "external" } ], "gene_names_uniprotkb": "Commd1; Murr1", "gene_names_refseq": "Commd1; Murr1; U2/Mu", "protein_names_uniprotkb": "COMM domain-containing protein 1; Protein Murr1", "protein_names_refseq": "COMM domain-containing protein 1 isoform 1; COMM domain-containing protein 1; U2af1-rs1 region 1; copper metabolism domain containing 1; protein Murr1", "tax_id": 10090, "disease": "", "pathway": " (mmu:17846); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11821379;12441649;14673161;21750661;28315936;33653183;33900545;34428180;36803109;37828378", "class_list": "", "function": "A novel transcript (U2mu) in mouse is transcribed from the portions of two independent genes, U2af1-rs1 and Murr1., [RefSeq, PubMed]; COMMD1 upregulation is involved in copper efflux from ischemic hearts., [RefSeq, PubMed]; Cardiomyocyte-Specific COMMD1 Deletion Suppresses Ischemia-Induced Myocardial Apoptosis., [RefSeq, PubMed]; Disruption of COMMD1 accelerates diabetic atherosclerosis by promoting glycolysis., [RefSeq, PubMed]; Inhibition of histone deacetylases alters allelic chromatin conformation at the imprinted U2af1-rs1 locus in mouse embryonic stem cells, [RefSeq, PubMed]; Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 (By similarity). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (By similarity). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (By similarity). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (By similarity). Promotes CFTR cell surface expression through regulation of its ubiquitination (By similarity). Down-regulates SOD1 activity by interfering with its homodimerization (By similarity). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (By similarity). Can bind one copper ion per monomer (By similarity). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (By similarity). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 (By similarity). Negatively regulates neuroblastoma G1/S phase cell cycle progression and cell proliferation by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a FAM107A- and actin-dependent manner (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V012;Q80WG2;Q80Z41;Q8BNL9;Q8K2S9", "ec_number_list": [], "go_molecular_function": "GO:0019871 sodium channel inhibitor activity;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome", "go_biological_process": "GO:0097006 regulation of plasma lipoprotein particle levels;GO:1902072 negative regulation of hypoxia-inducible factor-1alpha signaling pathway;GO:1904109 positive regulation of cholesterol import;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K4M5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCG4-1", "uniprot_id": [ { "id": "CO8G_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCG4", "type": "external" } ], "mass": 22508.0, "length": 202, "protein_name": "Complement component C8 gamma chain", "gene_name": "C8g", "organism": "Mouse", "refseq_name": "complement component C8 gamma chain isoform 1 precursor", "refseq_ac": [ { "id": "NP_081338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081338", "type": "external" } ], "gene_names_uniprotkb": "C8g", "gene_names_refseq": "C8g", "protein_names_uniprotkb": "Complement component C8 gamma chain", "protein_names_refseq": "complement component 8, gamma subunit; complement component C8 gamma chain isoform 1 precursor; complement component C8 gamma chain; novel lipocalin protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:69379); (R-MMU-166665); (R-MMU-977606)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;11058761;12220191;12413696;16944957;18440555", "class_list": "", "function": "A review of the human C8 gamma ortholog. Review article, [RefSeq, PubMed]; Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C8G, together with C8A and C8B, inserts into the target membrane, but does not form pores by itself. During MAC assembly, associates with C5b, C6 and C7 to form the C5b8 intermediate complex that inserts into the target membrane and traverses the bilayer increasing membrane rigidity., [UniProtKB, UniProtKB]; Results describe the crystal structure of the human ortholog C8 alpha MACPF domain disulfide-linked to C8 gamma (alphaMACPF-gamma) at 2.15 A resolution., [RefSeq, PubMed]; This gene encodes a secreted protein that is a core component of the complement 8 (C8) complex. C8 is part of the membrane attack complex which participates in the innate immune response against bacterial pathogens. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]., [RefSeq]; This is a study of the human C8 orthologs. Binding of C8 gamma subunit to C8 beta is dependent on the thrombospondin type 1 module, low-density lipoprotein receptor class A module, and membrane attack complex/perforin domain of C8 beta., [RefSeq, PubMed]; This is a study of the human orthologs of C8 alpha, beta, and gamma. C8 gamma is not required for complement-mediated killing of Gram-negative bacteria., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019841 retinol binding;GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:1902495 transmembrane transporter complex;GO:0005579 membrane attack complex;GO:0044218 other organism cell membrane", "go_biological_process": "GO:0031640 killing of cells of another organism;GO:0050778 positive regulation of immune response;GO:0006958 complement activation, classical pathway;GO:0006956 complement activation;GO:0006957 complement activation, alternative pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8VCG4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921H9-1", "uniprot_id": [ { "id": "COA7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921H9", "type": "external" } ], "mass": 25617.0, "length": 231, "protein_name": "Cytochrome c oxidase assembly factor 7", "gene_name": "Coa7", "organism": "Mouse", "refseq_name": "cytochrome c oxidase assembly factor 7", "refseq_ac": [ { "id": "NP_081526", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081526", "type": "external" } ], "gene_names_uniprotkb": "Coa7; Selrc1", "gene_names_refseq": "2010305A19Rik; Coa7; D4Ertd796e; Selrc1", "protein_names_uniprotkb": "Cytochrome c oxidase assembly factor 7; Beta-lactamase hcp-like protein; Respiratory chain assembly factor 1; Sel1 repeat-containing protein 1", "protein_names_refseq": "Sel1 repeat containing 1; beta-lactamase hcp-like protein; cytochrome c oxidase assembly factor 7; hcp beta-lactamase-like protein C1orf163 homolog; respiratory chain assembly factor 1; sel1 repeat-containing protein 1", "tax_id": 10090, "disease": "autosomal recessive spinocerebellar ataxia with axonal neuropathy 3 (Disease Ontology:DOID:0070465)", "pathway": " (mmu:69893)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;31219806", "class_list": "", "function": "Required for assembly of mitochondrial respiratory chain complex I and complex IV., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015035 protein-disulfide reductase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0008535 respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q921H9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D4A5-1", "uniprot_id": [ { "id": "CP086_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D4A5", "type": "external" } ], "mass": 32427.0, "length": 307, "protein_name": "Uncharacterized protein C16orf86 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C16orf86 homolog isoform 1", "refseq_ac": [ { "id": "NP_081931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081931", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "4933405L10Rik", "protein_names_uniprotkb": "Uncharacterized protein C16orf86 homolog", "protein_names_refseq": "uncharacterized protein C16orf86 homolog isoform 1; uncharacterized protein C16orf86 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:71046)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B7ZN89", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D4A5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7J7-1", "uniprot_id": [ { "id": "CPNS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7J7", "type": "external" } ], "mass": 27190.0, "length": 247, "protein_name": "Calpain small subunit 2", "gene_name": "Capns2", "organism": "Mouse", "refseq_name": "calpain small subunit 2", "refseq_ac": [ { "id": "NP_081388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081388", "type": "external" } ], "gene_names_uniprotkb": "Capns2", "gene_names_refseq": "2310005G05Rik; 30K-2; Capns2", "protein_names_uniprotkb": "Calpain small subunit 2; CSS2; Calcium-dependent protease small subunit 2", "protein_names_refseq": "CSS2; calcium-dependent protease small subunit 2; calpain small subunit 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:69543); (R-MMU-1474228); (R-MMU-9856530); (R-MMU-9860927)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0110158 calpain complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D7J7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D995-1", "uniprot_id": [ { "id": "CNTD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D995", "type": "external" } ], "mass": 37222.0, "length": 334, "protein_name": "Cyclin N-terminal domain-containing protein 1", "gene_name": "Cntd1", "organism": "Mouse", "refseq_name": "cyclin N-terminal domain-containing protein 1", "refseq_ac": [ { "id": "NP_080838", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080838", "type": "external" } ], "gene_names_uniprotkb": "Cntd1; Cntd", "gene_names_refseq": "1700051C09Rik; 4921513J16Rik; 5430417M23Rik; Cntd1; Cntd", "protein_names_uniprotkb": "Cyclin N-terminal domain-containing protein 1", "protein_names_refseq": "cyclin N-terminal domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68107)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "24891606;30779550;32555348;32640224", "class_list": "", "function": "CNTD1 has a critical role in meiotic crossover maturation and deselection of excess precrossover sites, [RefSeq, PubMed]; Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner., [RefSeq, PubMed]; Plays a role in the different steps of crossover formation during meiotic recombination (PubMed:24891606, PubMed:32555348, PubMed:32640224). Participates in the crossover differentiation step of crossover-specific recombination intermediates through its interaction with PRR19 (PubMed:32555348). In addition, stimulates crossover formation through the interactions with RFC3 and RFC4 and simultaneously regulates cell-cycle progression through interactions with CDC34 and subsequent ubiquitination of WEE1 (PubMed:32640224). May also participates in an active deselection process that destabilizes or removes excess pre-CO intermediates (PubMed:24891606)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D9L8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0035861 site of double-strand break;GO:0005694 chromosome", "go_biological_process": "GO:0007283 spermatogenesis;GO:0051445 regulation of meiotic cell cycle;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D995-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJZ9-1", "uniprot_id": [ { "id": "CNGB3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJZ9", "type": "external" } ], "mass": 79722.0, "length": 694, "protein_name": "Cyclic nucleotide-gated channel beta-3", "gene_name": "Cngb3", "organism": "Mouse", "refseq_name": "cyclic nucleotide-gated channel beta-3", "refseq_ac": [ { "id": "NP_038955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038955", "type": "external" } ], "gene_names_uniprotkb": "Cngb3; Cng6", "gene_names_refseq": "CCNC2; CNG6; Cngb3; Cngbeta2", "protein_names_uniprotkb": "Cyclic nucleotide-gated channel beta-3; CNG channel beta-3; Cone photoreceptor cGMP-gated channel subunit beta; Cyclic nucleotide-gated cation channel beta-3; Cyclic nucleotide-gated cation channel modulatory subunit; Cyclic nucleotide-gated channel subunit CNG6", "protein_names_refseq": "CNG channel beta-3; cone photoreceptor cGMP-gated channel subunit beta; cyclic nucleotide gated channel beta 6; cyclic nucleotide-gated cation channel beta-3; cyclic nucleotide-gated cation channel modulatory subunit; cyclic nucleotide-gated channel beta-3; cyclic nucleotide-gated channel subunit CNG6", "tax_id": 10090, "disease": "achromatopsia 3 (Disease Ontology:DOID:0110008); color blindness (Disease Ontology:DOID:13399)", "pathway": " (mmu:30952)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10662822;11764791;12432397;22299025;30592498;32869108", "class_list": "", "function": "Molecular and clinical characterization of Thai patients with achromatopsia: identification of three novel disease-associated variants in the CNGA3 and CNGB3 genes., [RefSeq, PubMed]; Pore-forming subunit of the cone cyclic nucleotide-gated channel. Mediates cone photoresponses at bright light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations., [UniProtKB, PubMed, UniProtKB]; The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry, [RefSeq, PubMed]; We identified the spontaneous occurrence of a 10th model of cone photoreceptor function loss (cpfl10) in an isolated line of inbred mice. Our results indicate that this is caused by a novel missense mutation in the Cngb3 gene, with a fully recessive inheritance pattern., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005223 intracellularly cGMP-activated cation channel activity;GO:0005222 intracellularly cAMP-activated cation channel activity;GO:0030553 cGMP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001750 photoreceptor outer segment;GO:0017071 intracellular cyclic nucleotide activated cation channel complex;GO:1902495 transmembrane transporter complex", "go_biological_process": "GO:0007601 visual perception;GO:0098655 monoatomic cation transmembrane transport;GO:0006812 monoatomic cation transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JJZ9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D937-1", "uniprot_id": [ { "id": "RSMC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D937", "type": "external" } ], "mass": 14099.0, "length": 123, "protein_name": "28S rRNA/ribosome and sororin micro-cofactor", "gene_name": "1810009A15Rik; Rsmc", "organism": "Mouse", "refseq_name": "uncharacterized protein C11orf98 homolog", "refseq_ac": [ { "id": "NP_079739", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079739", "type": "external" } ], "gene_names_uniprotkb": "1810009A15Rik; Rsmc", "gene_names_refseq": "1810009A15Rik", "protein_names_uniprotkb": "28S rRNA/ribosome and sororin micro-cofactor", "protein_names_refseq": "uncharacterized protein C11orf98 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66276)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;33649389;34428180;35820727", "class_list": "", "function": "Promotes sister chromatid cohesion by enhancing recruitment of CDCA5/sororin to chromatin during S phase and stimulating the anti-WAPL activity of CDCA5. Associates with the pre-60S ribosome and may be involved in pre-60S ribosome assembly., [UniProtKB, UniProtKB]; This gene shares three exons in common with another gene, LBH domain containing 1 (GeneID:102308570), but the encoded protein uses a reading frame that is different from that of the LBH domain containing 1 gene. [provided by RefSeq, Nov 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D937-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U497-1", "uniprot_id": [ { "id": "CLM7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U497", "type": "external" } ], "mass": 23755.0, "length": 209, "protein_name": "CMRF35-like molecule 7", "gene_name": "Cd300lb", "organism": "Mouse", "refseq_name": "CMRF35-like molecule 7 isoform 1 precursor", "refseq_ac": [ { "id": "NP_954691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954691", "type": "external" } ], "gene_names_uniprotkb": "Cd300lb; Irem3; Lmir5", "gene_names_refseq": "CLM-7; Cd300lb; Clm7; Gm253; LMIR5", "protein_names_uniprotkb": "CMRF35-like molecule 7; CD300 antigen-like family member B; CLM-7; IREM-3; Immune receptor expressed on myeloid cells 3; Leukocyte mono-Ig-like receptor 5", "protein_names_refseq": "CD300 antigen like family member B; CMRF-35-like molecule-7; CMRF35-like molecule 7 isoform 1 precursor; CMRF35-like molecule 7; IREM-3; immune receptor expressed on myeloid cells 3; leukocyte mono-Ig-like receptor 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:217304); (R-MMU-198933); (R-MMU-2172127)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "14662855;16920917;17928527;19144319;20566714;21750661;25172092;34428180", "class_list": "", "function": "Acts as an activating immune receptor in mast cells through its interaction with ITAM-bearing adapter TYROBP., [UniProtKB, PubMed]; Although both mouse and human LMIR5 play activatory roles in innate immunity cells, the functions of LMIR5 were differentially regulated in mouse versus human cells., [RefSeq, PubMed]; C. jejuni interacted preferentially with LMIR5., [RefSeq, PubMed]; TIM1 is an endogenous ligand for LMIR5., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q1ED86;Q3TCP3;Q6SJQ1", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0002446 neutrophil mediated immunity;GO:0071222 cellular response to lipopolysaccharide;GO:0002757 immune response-activating signaling pathway;GO:0033005 positive regulation of mast cell activation;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3U497-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQT6-1", "uniprot_id": [ { "id": "SMIP5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQT6", "type": "external" } ], "mass": 25817.0, "length": 229, "protein_name": "Sperm-associated microtubule inner protein 5", "gene_name": "Spmip5", "organism": "Mouse", "refseq_name": "sperm-associated microtubule inner protein 5 isoform 1", "refseq_ac": [ { "id": "NP_080484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080484", "type": "external" } ], "gene_names_uniprotkb": "Spmip5; 1700019N19Rik; Fam166d", "gene_names_refseq": "1700019N19Rik; Spmip5", "protein_names_uniprotkb": "Sperm-associated microtubule inner protein 5", "protein_names_refseq": "sperm associated microtubule inner protein 5; sperm-associated microtubule inner protein 5 isoform 1; uncharacterized protein C10orf82 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67507)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25609838;37295417", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme (PubMed:37295417). May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella (PubMed:37295417)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0036126 sperm flagellum;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CQT6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQI6-1", "uniprot_id": [ { "id": "COTL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQI6", "type": "external" } ], "mass": 15944.0, "length": 142, "protein_name": "Coactosin-like protein", "gene_name": "Cotl1", "organism": "Mouse", "refseq_name": "coactosin-like protein", "refseq_ac": [ { "id": "NP_082347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082347", "type": "external" } ], "gene_names_uniprotkb": "Cotl1; Clp", "gene_names_refseq": "1810074P22Rik; 2010004C08Rik; Clp; Cotl1", "protein_names_uniprotkb": "Coactosin-like protein", "protein_names_refseq": "coactosin-like 1; coactosin-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:72042); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11785969;20484733;21750661;31582545;32152506;37507081;39627609", "class_list": "", "function": "Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Coactosin-like 1 integrates signaling critical for shear-dependent thrombus formation in mouse platelets., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0019899 enzyme binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0030864 cortical actin cytoskeleton;GO:0030427 site of polarized growth;GO:0005856 cytoskeleton", "go_biological_process": "GO:0050832 defense response to fungus;GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CQI6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32M26-1", "uniprot_id": [ { "id": "CK087_MOUSE", "url": "https://www.uniprot.org/uniprot/Q32M26", "type": "external" } ], "mass": 20718.0, "length": 199, "protein_name": "Uncharacterized protein C11orf87 homolog", "gene_name": "AI593442", "organism": "Mouse", "refseq_name": "uncharacterized protein C11orf87 homolog precursor", "refseq_ac": [ { "id": "NP_001273570", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273570", "type": "external" } ], "gene_names_uniprotkb": "AI593442", "gene_names_refseq": "AI593442; E130102D23", "protein_names_uniprotkb": "Uncharacterized protein C11orf87 homolog", "protein_names_refseq": "uncharacterized protein C11orf87 homolog precursor; uncharacterized protein C11orf87 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:330941)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30899004", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8CC42", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q32M26-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7P7-1", "uniprot_id": [ { "id": "CLIC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7P7", "type": "external" } ], "mass": 26846.0, "length": 237, "protein_name": "Chloride intracellular channel protein 3", "gene_name": "Clic3", "organism": "Mouse", "refseq_name": "chloride intracellular channel protein 3", "refseq_ac": [ { "id": "NP_081361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081361", "type": "external" } ], "gene_names_uniprotkb": "Clic3", "gene_names_refseq": "2300003G24Rik; Clic3", "protein_names_uniprotkb": "Chloride intracellular channel protein 3; 1.8.-.-; Glutaredoxin-like oxidoreductase CLIC3", "protein_names_refseq": "chloride intracellular channel protein 3; glutaredoxin-like oxidoreductase CLIC3", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:69454)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;23280470;34428180", "class_list": "", "function": "CRIg signals induce anti-intracellular bacterial phagosome activity in a chloride intracellular channel 3-dependent manner., [RefSeq, PubMed]; In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduced in a glutathione-dependent way and secreted into the extracellular matrix where it activates TGM2 and promotes blood vessel growth during tissue remodeling as occurs in tumorigenesis. Can reduce specific cysteines in TGM2 and regulate cofactor binding (By similarity). Can insert into membranes and form outwardly rectifying chloride ion channels. May participate in cellular growth control (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0019153 protein-disulfide reductase (glutathione) activity;GO:0005254 chloride channel activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D7P7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q30D77-1", "uniprot_id": [ { "id": "COOA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q30D77", "type": "external" } ], "mass": 175733.0, "length": 1733, "protein_name": "Collagen alpha-1(XXIV) chain", "gene_name": "Col24a1", "organism": "Mouse", "refseq_name": "collagen alpha-1(XXIV) chain isoform 1 precursor", "refseq_ac": [ { "id": "NP_082046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082046", "type": "external" } ], "gene_names_uniprotkb": "Col24a1", "gene_names_refseq": "5430404K19Rik; Col24a1", "protein_names_uniprotkb": "Collagen alpha-1(XXIV) chain", "protein_names_refseq": "collagen alpha-1(XXIV) chain isoform 1 precursor; collagen alpha-1(XXIV) chain; procollagen, type XXIV, alpha 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71355); (R-MMU-1650814); (R-MMU-2022090); (R-MMU-8874081); (R-MMU-8948216)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "12874293;16373341;18382892;21750661;30084848", "class_list": "", "function": "Collagen XXIV is an ancient molecule that may contribute to the regulation of type I collagen fibrillogenesis at specific anatomical locations during fetal development, [RefSeq, PubMed]; Data report the characterization of the proximal promoter of the mouse collagen XXIV gene (Col24a1) and its regulation by CREB-AP1 in osteoblastic cells., [RefSeq, PubMed]; Involved in osteoblast differentiation., [UniProtKB, PubMed]; These findings lend further support to the hypothesis that collagen XXIV may be implicated in the formation of a mineralization-competent bone matrix., [RefSeq, PubMed]; This gene encodes the alpha-1 subunit of type XXIV collagen, one of the low abundance fibril-forming collagens found in cartilage. The encoded protein has structural features of invertebrate fibrillar collagens and is expressed predominantly in bone tissue. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]., [RefSeq]", "predicted_glycosites": 7, "predicted_n_glycosites": 4, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "B2RT51;E9QNS5", "ec_number_list": [], "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q30D77-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CRC3-1", "uniprot_id": [ { "id": "CO040_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CRC3", "type": "external" } ], "mass": 13189.0, "length": 126, "protein_name": "UPF0235 protein C15orf40 homolog", "gene_name": "3110040N11Rik", "organism": "Mouse", "refseq_name": "UPF0235 protein C15orf40 homolog isoform 2", "refseq_ac": [ { "id": "NP_080353", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080353", "type": "external" } ], "gene_names_uniprotkb": "3110040N11Rik", "gene_names_refseq": "3110040N11Rik", "protein_names_uniprotkb": "UPF0235 protein C15orf40 homolog", "protein_names_refseq": "UPF0235 protein C15orf40 homolog isoform 2; UPF0235 protein C15orf40 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67290)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K3A3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CRC3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CI04-1", "uniprot_id": [ { "id": "COG3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CI04", "type": "external" } ], "mass": 93283.0, "length": 820, "protein_name": "Conserved oligomeric Golgi complex subunit 3", "gene_name": "Cog3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cog3", "gene_names_refseq": "", "protein_names_uniprotkb": "Conserved oligomeric Golgi complex subunit 3; COG complex subunit 3; Component of oligomeric Golgi complex 3", "protein_names_refseq": "", "tax_id": 10090, "disease": "congenital disorder of glycosylation type IIbb (Disease Ontology:DOID:0051047)", "pathway": " (R-MMU-6807878); (R-MMU-6811438); (R-MMU-6811440)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "Involved in ER-Golgi transport. Also involved in retrograde (Golgi to ER) transport., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140312 cargo adaptor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032580 Golgi cisterna membrane;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0009101 glycoprotein biosynthetic process;GO:0050821 protein stabilization;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CI04-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BIG7-1", "uniprot_id": [ { "id": "CMTD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BIG7", "type": "external" } ], "mass": 28961.0, "length": 262, "protein_name": "Catechol O-methyltransferase domain-containing protein 1", "gene_name": "Comtd1", "organism": "Mouse", "refseq_name": "catechol O-methyltransferase domain-containing protein 1", "refseq_ac": [ { "id": "NP_081241", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081241", "type": "external" } ], "gene_names_uniprotkb": "Comtd1", "gene_names_refseq": "1810030M08Rik; Comtd1; MT773", "protein_names_uniprotkb": "Catechol O-methyltransferase domain-containing protein 1; 2.1.1.-", "protein_names_refseq": "O-methyltransferase-containing protein; catechol O-methyltransferase domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69156)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25605945;37068079", "class_list": "", "function": "A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken. Publication Status: Online-Only, [RefSeq, PubMed]; Putative O-methyltransferase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0008171 O-methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BIG7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09174-1", "uniprot_id": [ { "id": "CNRG_MOUSE", "url": "https://www.uniprot.org/uniprot/P09174", "type": "external" } ], "mass": 9637.0, "length": 87, "protein_name": "Rod cGMP 3',5'-cyclic phosphodiesterase subunit gamma", "gene_name": "Pde6g", "organism": "Mouse", "refseq_name": "retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma", "refseq_ac": [ { "id": "NP_036197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036197", "type": "external" } ], "gene_names_uniprotkb": "Pde6g; Pdeg", "gene_names_refseq": "Pde6g; Pdeg; p3AT", "protein_names_uniprotkb": "Rod cGMP 3',5'-cyclic phosphodiesterase subunit gamma; Rod GMP-PDE gamma", "protein_names_refseq": "GMP-PDE gamma; cGMP phosphodiesterase gamma; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma", "tax_id": 10090, "disease": "retinitis pigmentosa 57 (Disease Ontology:DOID:0110407); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:18588); (R-MMU-2485179); (R-MMU-2514859); (R-MMU-4086398)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "2835267", "class_list": "", "function": "Inhibitory gamma subunit of the rod-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade. The PDE6 holoenzyme consists of two catalytic subunits (PDE6A and PDE6B) and two inhibitory gamma subunits. Light-activated GNAT1 relieves gamma subunit-mediated inhibition, enabling the catalytic subunits to hydrolyze cGMP and thereby mediate visual signal transduction and amplification., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0030507 spectrin binding;GO:0030553 cGMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001750 photoreceptor outer segment;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0043410 positive regulation of MAPK cascade;GO:0045745 positive regulation of G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P09174-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21844-1", "uniprot_id": [ { "id": "CMA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P21844", "type": "external" } ], "mass": 27586.0, "length": 247, "protein_name": "Chymase", "gene_name": "Cma1", "organism": "Mouse", "refseq_name": "chymase preproprotein", "refseq_ac": [ { "id": "NP_034910", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034910", "type": "external" } ], "gene_names_uniprotkb": "Cma1; Mcpt5", "gene_names_refseq": "Cma1; MMCP-5; Mcp-5; Mcp5; Mcpt5", "protein_names_uniprotkb": "Chymase; 3.4.21.39; Alpha-chymase; Mast cell chymase 1; Mast cell protease 5; Mast cell protease I; mMCP-5", "protein_names_refseq": "alpha-chymase; chymase preproprotein; mast cell chymase 1; mast cell protease 5; mast cell protease I", "tax_id": 10090, "disease": "sarcoidosis (Disease Ontology:DOID:11335); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); renovascular hypertension (Disease Ontology:DOID:1591); congenital heart disease (Disease Ontology:DOID:1682); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310)", "pathway": " (mmu:17228); (R-MMU-1433557); (R-MMU-1592389); (R-MMU-2022377)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11398967;1376147;1527387;1939089;2060576;2326280;27302551;28193842;34428180;38214098", "class_list": "", "function": "Fibronectin was identified as a target of mMCP-5, and the exocytosis of mMCP-5 from the MCs in the mouse's peritoneal cavity resulted in the expression of metalloproteinase protease-9, which has been implicated in arthritis., [RefSeq, PubMed]; MCP-5 suppresses osteoclast differentiation through Ccr5 upregulation., [RefSeq, PubMed]; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion., [UniProtKB]; Mast cells have the ability to produce and degrade FXIIIA depending on their chymase expression profile: mast cells expressing chymase degrade FXIIIA, whereas mast cells that do not express chymase mainly produce FXIIIA, [RefSeq, PubMed]; This gene encodes a serine protease that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. The encoded preproprotein undergoes proteolytic processing to generate a functional enzyme with elastase-like activity. Mice lacking the encoded protein exhibit significant attenuation of ischemia-reperfusion injury of the skeletal muscle. This gene is located in a cluster of related mast cell protease genes on chromosome 14. [provided by RefSeq, Nov 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9R1F0", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.21.39", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.39", "type": "external" }, { "id": "3.4.21.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.59", "type": "external" }, { "id": "3.4.21.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.34", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0042277 peptide binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0030141 secretory granule;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0016485 protein processing;GO:0022617 extracellular matrix disassembly;GO:0045766 positive regulation of angiogenesis;GO:0050727 regulation of inflammatory response;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P21844-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05306-1", "uniprot_id": [ { "id": "COAA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q05306", "type": "external" } ], "mass": 66775.0, "length": 680, "protein_name": "Collagen alpha-1(X) chain", "gene_name": "Col10a1", "organism": "Mouse", "refseq_name": "collagen alpha-1(X) chain precursor", "refseq_ac": [ { "id": "NP_034055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034055", "type": "external" } ], "gene_names_uniprotkb": "Col10a1", "gene_names_refseq": "Col10a-1; Col10a1; Col10", "protein_names_uniprotkb": "Collagen alpha-1(X) chain", "protein_names_refseq": "collagen alpha-1(X) chain precursor; collagen alpha-1(X) chain; procollagen, type X, alpha 1", "tax_id": 10090, "disease": "Schmid metaphyseal chondrodysplasia (Disease Ontology:DOID:0080021); osteochondrodysplasia (Disease Ontology:DOID:2256); lung adenocarcinoma (Disease Ontology:DOID:3910); degenerative disc disease (Disease Ontology:DOID:90)", "pathway": " (mmu:12813); (R-MMU-1442490); (R-MMU-1650814); (R-MMU-2022090); (R-MMU-3000171); (R-MMU-8948216)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "1543751;1587271;35820727;8424763;8477738;8492743", "class_list": "", "function": "Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0005938 cell cortex;GO:0031012 extracellular matrix;GO:0043235 receptor complex;GO:0005581 collagen trimer;GO:0005599 collagen type X trimer", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0051216 cartilage development;GO:0001958 endochondral ossification", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q05306-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61908-1", "uniprot_id": [ { "id": "CMC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61908", "type": "external" } ], "mass": 7743.0, "length": 68, "protein_name": "Cx9C motif-containing protein 4", "gene_name": "Cmc4", "organism": "Mouse", "refseq_name": "cx9C motif-containing protein 4", "refseq_ac": [ { "id": "NP_001281206", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281206", "type": "external" } ], "gene_names_uniprotkb": "Cmc4; C6.1b; Mtcp1", "gene_names_refseq": "Cmc4; Mtcp1nb; p8MTCP1", "protein_names_uniprotkb": "Cx9C motif-containing protein 4; MTCP-1 type A; Mature T-cell proliferation 1 neighbor protein; Mature T-cell proliferation-1 type A; Protein p8 MTCP-1; p8MTCP1", "protein_names_refseq": "C-x(9)-C motif containing 4; MTCP-1 type A; cx9C motif-containing protein 4; mature T-cell proliferation 1 neighbor protein; mature T-cell proliferation-1 type A; protein p8 MTCP-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:105886298)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "7784073;7970717", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q61908-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63829-1", "uniprot_id": [ { "id": "COMD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q63829", "type": "external" } ], "mass": 22037.0, "length": 195, "protein_name": "COMM domain-containing protein 3", "gene_name": "Commd3", "organism": "Mouse", "refseq_name": "COMM domain-containing protein 3", "refseq_ac": [ { "id": "NP_680087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_680087", "type": "external" } ], "gene_names_uniprotkb": "Commd3; Bup", "gene_names_refseq": "Bup; Commd3; D2Ertd542e", "protein_names_uniprotkb": "COMM domain-containing protein 3; Bmi-1 upstream gene protein; Bup protein", "protein_names_refseq": "Bmi1 upstream; COMM domain-containing protein 3; bmi-1 upstream gene protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:12238); (R-MMU-6798695); (R-MMU-8951664)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "1287475;25605945;34428180;37072858", "class_list": "", "function": "COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (By similarity). May down-regulate activation of NF-kappa-B (By similarity). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ASR4;Q3UKI1;Q8C9P5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006878 intracellular copper ion homeostasis;GO:0009725 response to hormone;GO:0006814 sodium ion transport;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q63829-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80Y73-1", "uniprot_id": [ { "id": "HOATZ_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80Y73", "type": "external" } ], "mass": 19068.0, "length": 168, "protein_name": "Cilia- and flagella-associated protein HOATZ", "gene_name": "Hoatz", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein HOATZ", "refseq_ac": [ { "id": "NP_808370", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808370", "type": "external" } ], "gene_names_uniprotkb": "Hoatz; Hoatzin", "gene_names_refseq": "4833427G06Rik; Hoatzin; Hoatz", "protein_names_uniprotkb": "Cilia- and flagella-associated protein HOATZ", "protein_names_refseq": "UPF0722 protein C11orf88 homolog; cilia- and flagella-associated protein HOATZ; protein Hoatz", "tax_id": 10090, "disease": "", "pathway": " (mmu:235345)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17971504;32248064;36098411", "class_list": "", "function": "4833427G06Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Carboxyl Terminus of HOATZ is Intrinsically Disordered and Interacts with Heat Shock Protein A Families., [RefSeq, PubMed]; Required for motile ciliogenesis and flagellar genesis by mediating the maturation of the glycolytic enzyme ENO4., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V0W8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005929 cilium", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly;GO:0035082 axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80Y73-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZY2-1", "uniprot_id": [ { "id": "COMDA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZY2", "type": "external" } ], "mass": 22812.0, "length": 202, "protein_name": "COMM domain-containing protein 10", "gene_name": "Commd10", "organism": "Mouse", "refseq_name": "COMM domain-containing protein 10 isoform 1", "refseq_ac": [ { "id": "NP_848464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848464", "type": "external" } ], "gene_names_uniprotkb": "Commd10", "gene_names_refseq": "2310003A05Rik; Commd10; DRWMS2; Tg(Vav1-icre)A2Kio; Vav-cre; Vav-iCre; Vav1-Cre; VavCre", "protein_names_uniprotkb": "COMM domain-containing protein 10; Down-regulated in W/WV mouse stomach 2; mDRWMS2", "protein_names_refseq": "COMM domain-containing protein 10 isoform 1; COMM domain-containing protein 10; Tg(Vav1-cre)1Kio; Tg(Vav1-cre)A2Kio; down-regulated in W/WV mouse stomach 2; mDRWMS2", "tax_id": 10090, "disease": "", "pathway": " (mmu:69456); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (By similarity). May down-regulate activation of NF-kappa-B (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8JZY2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R373-1", "uniprot_id": [ { "id": "CLMP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R373", "type": "external" } ], "mass": 41215.0, "length": 373, "protein_name": "CXADR-like membrane protein", "gene_name": "Clmp", "organism": "Mouse", "refseq_name": "CXADR-like membrane protein precursor", "refseq_ac": [ { "id": "NP_598494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598494", "type": "external" } ], "gene_names_uniprotkb": "Clmp; Acam; Asam; Asp5", "gene_names_refseq": "9030425E11Rik; ACAM; ASP5; Clmp", "protein_names_uniprotkb": "CXADR-like membrane protein; Adipocyte adhesion molecule; Adipocyte-specific protein 5; CAR-like membrane protein; Coxsackie- and adenovirus receptor-like membrane protein", "protein_names_refseq": "CAR-like membrane protein; CXADR-like membrane protein precursor; adipocyte adhesion molecule; adipocyte-specific protein 5; coxsackie- and adenovirus receptor-like membrane protein", "tax_id": 10090, "disease": "short bowel syndrome (Disease Ontology:DOID:10605)", "pathway": " (mmu:71566)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;14573622;15563274;17620326;19656770;25428506", "class_list": "", "function": "Expression of CLMP, a novel tight junction protein, is mediated via the interaction of GATA with the Kruppel family proteins, KLF4 and Sp1, in mouse TM4 Sertoli cells., [RefSeq, PubMed]; May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development (By similarity)., [UniProtKB, PubMed, PubMed]; We identified ACAM (adipocyte adhesion molecule), a novel homologue of the CTX (cortical thymocyte marker in Xenopus) gene family, which may be the critical adhesion molecule in adipocyte differentiation and development of obesity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q920S5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005923 bicellular tight junction;GO:0045211 postsynaptic membrane;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0007155 cell adhesion;GO:0060612 adipose tissue development;GO:0030041 actin filament polymerization;GO:0048565 digestive tract development;GO:0034333 adherens junction assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8R373-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCH2-1", "uniprot_id": [ { "id": "CLM5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCH2", "type": "external" } ], "mass": 24954.0, "length": 221, "protein_name": "CMRF35-like molecule 5", "gene_name": "Cd300ld", "organism": "Mouse", "refseq_name": "CMRF35-like molecule 5 precursor", "refseq_ac": [ { "id": "NP_663412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663412", "type": "external" } ], "gene_names_uniprotkb": "Cd300ld; Clm5; Lmir4", "gene_names_refseq": "4732429D16Rik; CLM5; Cd300ld1; Cd300ld; LMIR4; MAIR-IV; clm-5", "protein_names_uniprotkb": "CMRF35-like molecule 5; CD300 antigen like family member D; CLM-5; Leukocyte mono-Ig-like receptor 4; MAIR-4; MAIR-IV; Myeloid-associated immunoglobulin-like receptor 4", "protein_names_refseq": "CD300 antigen like family member D; CMRF35-like molecule 5 precursor; CMRF35-like molecule 5; MAIR-4; leukocyte mono-Ig-like receptor 4; myeloid-associated immunoglobulin (Ig)-like receptor IV; myeloid-associated immunoglobulin-like receptor 4; novel immunoglobulin V-set protein (Clm5)", "tax_id": 10090, "disease": "", "pathway": " (mmu:217305); (R-MMU-198933)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14662855;16940041;17438331;17543387;20817736;27540007;27681626;37674079", "class_list": "", "function": "(Microbial infection) Acts as a functional murine norovirus (MNV) receptor. Primary determinant of MNV species tropism and is sufficient to render cells permissive to infection by MNV. Can render nonmurine mammalian cells susceptible to MNV infection (PubMed:27540007, PubMed:27681626)., [UniProtKB, PubMed, PubMed]; Acts as an activating receptor in myeloid cells and mast cells., [UniProtKB, PubMed, PubMed]; CD300ld on neutrophils is required for tumour-driven immune suppression., [RefSeq, PubMed]; Data show that LMIR7/CLM-3 shares similarities with LMIR4/CLM-5, although they are differentially regulated in their distribution, expression, and function., [RefSeq, PubMed]; MAIR-IV may regulate activation of neutrophils and play an important role for innate immunity., [RefSeq, PubMed]; Our results indicate that direct interaction of MNV with two cell-surface molecules, CD300lf and CD300ld, dictates permissive noroviral infection., [RefSeq, PubMed]; The innate immune system is at least in part regulated by the qualitative and quantitative balance of the paired receptors LMIR3 and LMIR4, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BRU3", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0001618 virus receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0032675 regulation of interleukin-6 production;GO:0032680 regulation of tumor necrosis factor production;GO:0002757 immune response-activating signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VCH2-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCP9-1", "uniprot_id": [ { "id": "CLC14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCP9", "type": "external" } ], "mass": 49066.0, "length": 459, "protein_name": "C-type lectin domain family 14 member A", "gene_name": "Clec14a", "organism": "Mouse", "refseq_name": "C-type lectin domain family 14 member A precursor", "refseq_ac": [ { "id": "NP_080085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080085", "type": "external" } ], "gene_names_uniprotkb": "Clec14a", "gene_names_refseq": "1200003C23Rik; Clec14a", "protein_names_uniprotkb": "C-type lectin domain family 14 member A", "protein_names_refseq": "C-type lectin domain family 14 member A precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:66864)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21095181;21183079;23644659;25428506;32019570;34107098", "class_list": "glycogene", "function": "CLEC14A deficiency exacerbates neuronal loss by increasing blood-brain barrier permeability and inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; CLEC14A protects against podocyte injury in mice with adriamycin nephropathy., [RefSeq, PubMed]; Clec14a-CTLD may be a key domain in angiogenesis, [RefSeq, PubMed]; These findings demonstrate that Clec14a is a novel endothelial cells specific protein that appears to play a role in cell-cell adhesion and angiogenesis., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 30, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3TP72;Q9CXA8;Q9D624;Q9DC55", "ec_number_list": [], "go_molecular_function": "GO:1990430 extracellular matrix protein binding;GO:0030246 carbohydrate binding;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0016477 cell migration;GO:0001946 lymphangiogenesis;GO:0002040 sprouting angiogenesis;GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway;GO:0002042 cell migration involved in sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8VCP9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000011001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1Z2-1", "uniprot_id": [ { "id": "CK091_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1Z2", "type": "external" } ], "mass": 20754.0, "length": 194, "protein_name": "Uncharacterized protein C11orf91 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C11orf91 homolog", "refseq_ac": [ { "id": "NP_080910", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080910", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "A930018P22Rik", "protein_names_uniprotkb": "Uncharacterized protein C11orf91 homolog", "protein_names_refseq": "uncharacterized protein C11orf91 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68243)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D1Z2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D486-1", "uniprot_id": [ { "id": "CMIP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D486", "type": "external" } ], "mass": 86259.0, "length": 773, "protein_name": "C-Maf-inducing protein", "gene_name": "Cmip", "organism": "Mouse", "refseq_name": "C-Maf-inducing protein isoform 1", "refseq_ac": [ { "id": "NP_001156734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156734", "type": "external" } ], "gene_names_uniprotkb": "Cmip; Kiaa1694", "gene_names_refseq": "4933407C03Rik; 5830471E12Rik; Cmip", "protein_names_uniprotkb": "C-Maf-inducing protein; c-Mip", "protein_names_refseq": "C-Maf-inducing protein isoform 1; C-Maf-inducing protein; c-Mip", "tax_id": 10090, "disease": "", "pathway": " (mmu:74440)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "20808911;23200848;25428506;26495903;26740625;27650733;28011936;31209405;31395948;32152506;32848054;36609599", "class_list": "", "function": "CMIP is a negative regulator of T cell signaling., [RefSeq, PubMed]; Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Ppargamma-CD36 axis., [RefSeq, PubMed]; Expression of Cmip in the mouse hippocampus is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase). Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in T-cell signaling pathway., [UniProtKB]; The c-mip protein is involve in regulating nephrin phosphorylation through Csk-Cbp/PAG-Fyn signaling pathway., [RefSeq, PubMed]; Unlike the human CMIP gene, only one Wt1 response element was identified in the mouse Cmip proximal promoter located at position -217/-206., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZD2;Q8C3N2;Q8K148", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9D486-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9H2-1", "uniprot_id": [ { "id": "CLDN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9H2", "type": "external" } ], "mass": 18250.0, "length": 167, "protein_name": "Claudin domain-containing protein 2", "gene_name": "Cldnd2", "organism": "Mouse", "refseq_name": "claudin domain-containing protein 2 isoform 1", "refseq_ac": [ { "id": "NP_083125", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083125", "type": "external" } ], "gene_names_uniprotkb": "Cldnd2", "gene_names_refseq": "1700071E18Rik; Cldnd2", "protein_names_uniprotkb": "Claudin domain-containing protein 2", "protein_names_refseq": "claudin domain-containing protein 2 isoform 1; claudin domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74276)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D9H2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9N5-1", "uniprot_id": [ { "id": "CIB4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9N5", "type": "external" } ], "mass": 21637.0, "length": 185, "protein_name": "Calcium and integrin-binding family member 4", "gene_name": "Cib4", "organism": "Mouse", "refseq_name": "calcium and integrin-binding family member 4 isoform 1", "refseq_ac": [ { "id": "NP_082759", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082759", "type": "external" } ], "gene_names_uniprotkb": "Cib4", "gene_names_refseq": "1700041E20Rik; Cib4", "protein_names_uniprotkb": "Calcium and integrin-binding family member 4", "protein_names_refseq": "calcium and integrin-binding family member 4 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:73259)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18989529;32430498", "class_list": "", "function": "CIB4 is essential for the haploid phase of spermatogenesis in micedagger., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005509 calcium ion binding", "go_cellular_component": "", "go_biological_process": "GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D9N5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ET38-1", "uniprot_id": [ { "id": "CLD19_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ET38", "type": "external" } ], "mass": 23343.0, "length": 224, "protein_name": "Claudin-19", "gene_name": "Cldn19", "organism": "Mouse", "refseq_name": "claudin-19 isoform 1", "refseq_ac": [ { "id": "NP_001033679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033679", "type": "external" } ], "gene_names_uniprotkb": "Cldn19", "gene_names_refseq": "Cldn19", "protein_names_uniprotkb": "Claudin-19", "protein_names_refseq": "claudin-19 isoform 1", "tax_id": 10090, "disease": "renal hypomagnesemia 5 with ocular involvement (Disease Ontology:DOID:0060881)", "pathway": " (mmu:242653)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15589828;15883201;19706394;25678664;28028216;30937396;37344378", "class_list": "", "function": "Claudin-19 localizes to the thick ascending limb where its expression is required for junctional claudin-16 localization., [RefSeq, PubMed]; Forms paracellular channels: coassembles with CLDN16 into tight junction strands with cation-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (By similarity) (PubMed:19706394). Involved in the maintenance of ion gradients along the nephron. In the thick ascending limb (TAL) of Henle's loop, facilitates sodium paracellular permeability from the interstitial compartment to the lumen, contributing to the lumen-positive transepithelial potential that drives paracellular magnesium and calcium reabsorption (PubMed:28028216). Forms paracellular barriers on its own. In the peripheral nervous system, represents a major constituent of the tight junctions in Schwann cells and contributes to electrical sealing. During retinal neurogenesis, may regulate the barrier properties of tight junctions in retinal pigment epithelium, required for proper retinal tissue differentiation and vision (PubMed:15883201, PubMed:30937396)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Sp1 site is crucial for Cldn19 gene expression in kidney cells., [RefSeq, PubMed]; This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. siRNA knockdown of this gene in mice develops the FHHNC (familial hypomagnesemia with hypercalciuria and nephrocalcinosis) symptoms of chronic renal wasting of magnesium and calcium together with defective renal salt handling. The protein encoded by this gene interacts with another family member, Claudin 16, and their interaction is required for their assembly into tight junctions and for renal reabsorption of magnesium. This protein is a constituent of tight junctions in the Schwann cells of peripheral myelinated nerves and the gene deficiency affects the nerve conduction of peripheral myelinated fibers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 43, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R4B7", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity;GO:0098632 cell-cell adhesion mediator activity;GO:0160187 paracellular tight junction channel activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0043297 apical junction assembly;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0034329 cell junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9ET38-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ET43-1", "uniprot_id": [ { "id": "CLD12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ET43", "type": "external" } ], "mass": 26995.0, "length": 244, "protein_name": "Claudin-12", "gene_name": "Cldn12", "organism": "Mouse", "refseq_name": "claudin-12", "refseq_ac": [ { "id": "NP_001180588", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180588", "type": "external" } ], "gene_names_uniprotkb": "Cldn12", "gene_names_refseq": "Cldn12", "protein_names_uniprotkb": "Claudin-12", "protein_names_refseq": "claudin-12", "tax_id": 10090, "disease": "", "pathway": " (mmu:64945)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;14698084;21183079;22645316;30734065;32848054;34428180;37527762;40885482", "class_list": "", "function": "Claudin-12 is expressed at the variety of epithelial tissues in inner ear including Organ of Corti, stria vascularis, Reissner's membrane, spiral limbus, vestibular sensory epithelia, and dark cell area., [RefSeq, PubMed]; Myelin barrier breakdown, mechanical hypersensitivity, and painfulness in polyneuropathy with claudin-12 deficiency., [RefSeq, PubMed]; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity., [UniProtKB]; This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene, along with several other family members, is expressed in the inner ear. The protein encoded by this gene and another family member, claudin 2, are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found. [provided by RefSeq, Oct 2011]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TM65;Q8BH13", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0071944 cell periphery;GO:0016328 lateral plasma membrane;GO:0070160 tight junction", "go_biological_process": "GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9ET43-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51175-1", "uniprot_id": [ { "id": "PPOX_MOUSE", "url": "https://www.uniprot.org/uniprot/P51175", "type": "external" } ], "mass": 50871.0, "length": 477, "protein_name": "Protoporphyrinogen oxidase", "gene_name": "Ppox", "organism": "Mouse", "refseq_name": "protoporphyrinogen oxidase", "refseq_ac": [ { "id": "NP_032937", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032937", "type": "external" } ], "gene_names_uniprotkb": "Ppox", "gene_names_refseq": "Ppox; Ppo", "protein_names_uniprotkb": "Protoporphyrinogen oxidase; 1.3.3.4; PPO", "protein_names_refseq": "protoporhyrinogen oxidase; protoporphyrinogen oxidase", "tax_id": 10090, "disease": "porphyria (Disease Ontology:DOID:13268); variegate porphyria (Disease Ontology:DOID:4346)", "pathway": " (mmu:19044); (R-MMU-189451)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21750661;25428506;30366982;3346226;34428180;7607249;8554330", "class_list": "", "function": "Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97344;Q99M34", "ec_number_list": [ { "id": "1.3.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.4", "type": "external" } ], "go_molecular_function": "GO:0004729 oxygen-dependent protoporphyrinogen oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006779 porphyrin-containing compound biosynthetic process;GO:0009410 response to xenobiotic stimulus;GO:0006783 heme biosynthetic process;GO:0006782 protoporphyrinogen IX biosynthetic process;GO:0046501 protoporphyrinogen IX metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P51175-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q148A4-1", "uniprot_id": [ { "id": "SAXO4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q148A4", "type": "external" } ], "mass": 47809.0, "length": 427, "protein_name": "Stabilizer of axonemal microtubules 4", "gene_name": "Saxo4", "organism": "Mouse", "refseq_name": "stabilizer of axonemal microtubules 4", "refseq_ac": [ { "id": "NP_598450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598450", "type": "external" } ], "gene_names_uniprotkb": "Saxo4; Ppp1r32", "gene_names_refseq": "4930579J09Rik; IIIG9L; IIIG9S; IIIG9; Ppp1r32; Saxo4", "protein_names_uniprotkb": "Stabilizer of axonemal microtubules 4; Protein phosphatase 1 regulatory subunit 32", "protein_names_refseq": "protein phosphatase 1, regulatory subunit 32; stabilizer of axonemal microtubules 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:67752)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15018803;21750661;37295417", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91XJ2", "ec_number_list": [], "go_molecular_function": "GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0160111 axonemal A tubule inner sheath;GO:0036064 ciliary basal body", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q148A4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61038-1", "uniprot_id": [ { "id": "GPR65_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61038", "type": "external" } ], "mass": 39388.0, "length": 337, "protein_name": "G protein-coupled receptor 65", "gene_name": "Gpr65", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 65", "refseq_ac": [ { "id": "NP_032178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032178", "type": "external" } ], "gene_names_uniprotkb": "Gpr65; Gpcr25; Tdag8", "gene_names_refseq": "Dig1; Gpcr25; Gpr65; TDAG8", "protein_names_uniprotkb": "G protein-coupled receptor 65; T-cell death-associated gene 8 protein", "protein_names_refseq": "G-protein coupled receptor 25; G-protein coupled receptor 65; T-cell death-associated gene 8 protein; psychosine receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:14744); (R-MMU-373076); (R-MMU-416476)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "15326175;15485889;21750661;27287411;35668320;39123083;39423285;39661058;8599842", "class_list": "", "function": "GPR65 contributes to constructing immunosuppressive microenvironment in glioma. Publication Status: Online-Only, [RefSeq, PubMed]; Proton-sensing G protein-coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions (PubMed:39661058). Activated by an optimal pH of 7.4 (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). GPR65 is mainly coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (By similarity). May also act as a receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids (By similarity). Plays a role in immune response by maintaining lysosome function and regulating T-cell metabolism (PubMed:27287411, PubMed:8599842). Acts as a regulator of inflammation by mediating pH-sensing of extracellular acidification which takes place in inflamed tissues: activation regulates endo-lysosomal function of immune cells and T-cell metabolism (PubMed:35668320, PubMed:39661058). Constitutively active in endosomes and stimulates adenylate cyclase production from endosomes independently from extracellular pH changes (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; TDAG8 is a regulator of glucocorticoid-induced apoptosis, [RefSeq, PubMed]; TDAG8 is one of the proton-sensing GPCRs coupling to adenylyl cyclase and psychosine, and its related lysosphingolipids behave as if they were antagonists against protein-sensing receptors, including TDAG8, GPR4, and OGR1., [RefSeq, PubMed]; The acid-sensing receptor GPR65 on tumor macrophages drives tumor growth in obesity., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q921N3", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0006915 apoptotic process;GO:0051496 positive regulation of stress fiber assembly;GO:0010447 response to acidic pH", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q61038-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CY94-1", "uniprot_id": [ { "id": "PSF3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CY94", "type": "external" } ], "mass": 24577.0, "length": 216, "protein_name": "DNA replication complex GINS protein PSF3", "gene_name": "Gins3", "organism": "Mouse", "refseq_name": "DNA replication complex GINS protein PSF3", "refseq_ac": [ { "id": "NP_084474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084474", "type": "external" } ], "gene_names_uniprotkb": "Gins3; Psf3", "gene_names_refseq": "2700085M18Rik; Gins3; Psf3", "protein_names_uniprotkb": "DNA replication complex GINS protein PSF3; GINS complex subunit 3", "protein_names_refseq": "DNA replication complex GINS protein PSF3; GINS complex subunit 3 (Psf3 homolog)", "tax_id": 10090, "disease": "Meier-Gorlin syndrome (Disease Ontology:DOID:0060306)", "pathway": " (mmu:78833); (R-MMU-176974)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17127213;21750661;31219806;35603789", "class_list": "", "function": "Expression of mammalian GINS is regulated by 17beta-Estradiol-stimulated estrogen receptor alpha, and PSF3 acts as a gene responsive to transcription factor E2F1, [RefSeq, PubMed]; Hypomorphic GINS3 variants alter DNA replication and cause Meier-Gorlin syndrome. Publication Status: Online-Only, [RefSeq, PubMed]; Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built., [UniProtKB, UniProtKB]; The GINS complex plays an essential role in the initiation of DNA replication., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000811 GINS complex;GO:0071162 CMG complex", "go_biological_process": "GO:0035264 multicellular organism growth;GO:0006260 DNA replication;GO:0090398 cellular senescence;GO:0006270 DNA replication initiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CY94-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18121-1", "uniprot_id": [ { "id": "PR3D1_MOUSE", "url": "https://www.uniprot.org/uniprot/P18121", "type": "external" } ], "mass": 25524.0, "length": 224, "protein_name": "Prolactin-3D1", "gene_name": "Prl3d1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prl3d1; Csh1; Pl-1; Pl1", "gene_names_refseq": "", "protein_names_uniprotkb": "Prolactin-3D1; Chorionic somatomammotropin hormone 1; PL-I; Placental lactogen I", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:18775)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;3153461;8043949;8469232", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P18121-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D3U0-1", "uniprot_id": [ { "id": "PUS10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D3U0", "type": "external" } ], "mass": 59710.0, "length": 527, "protein_name": "tRNA pseudouridine synthase Pus10", "gene_name": "Pus10", "organism": "Mouse", "refseq_name": "tRNA pseudouridine synthase Pus10 isoform 1", "refseq_ac": [ { "id": "NP_001028826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028826", "type": "external" } ], "gene_names_uniprotkb": "Pus10; Ccdc139", "gene_names_refseq": "2810013G11Rik; 4933435A13Rik; Ccdc139; Pus10", "protein_names_uniprotkb": "tRNA pseudouridine synthase Pus10; 5.4.99.25; Coiled-coil domain-containing protein 139; Psi55 synthase; tRNA pseudouridine 55 synthase; tRNA pseudouridylate synthase; tRNA-uridine isomerase", "protein_names_refseq": "coiled-coil domain containing 139; coiled-coil domain-containing protein 139; psi55 synthase; putative tRNA pseudouridine synthase Pus10; tRNA pseudouridine 55 synthase; tRNA pseudouridine synthase Pus10 isoform 1; tRNA pseudouridylate synthase; tRNA-uridine isomerase", "tax_id": 10090, "disease": "", "pathway": " (mmu:74467)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;34428180", "class_list": "", "function": "Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm. In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs. tRNA pseudouridylate synthase activity is enhanced by the presence of 1-methyladenosine at position 53-61 of tRNAs. Does not show tRNA pseudouridylate synthase activity in the nucleus. In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity. Binds pri-miRNAs. Modulator of TRAIL/TNFSF10-induced cell death via activation of procaspase-8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UM90;Q8BSZ4;Q8CDM2;Q9CSI7", "ec_number_list": [ { "id": "5.4.99.25", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.25", "type": "external" }, { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0009982 pseudouridine synthase activity;GO:0070878 primary miRNA binding;GO:0106029 tRNA pseudouridine synthase activity;GO:0160148 tRNA pseudouridine(55) synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0031119 tRNA pseudouridine synthesis;GO:0031053 primary miRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D3U0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZ67-1", "uniprot_id": [ { "id": "PPM1D_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZ67", "type": "external" } ], "mass": 65723.0, "length": 598, "protein_name": "Protein phosphatase 1D", "gene_name": "Ppm1d", "organism": "Mouse", "refseq_name": "protein phosphatase 1D", "refseq_ac": [ { "id": "NP_058606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058606", "type": "external" } ], "gene_names_uniprotkb": "Ppm1d; Wip1", "gene_names_refseq": "Ppm1d; Wip1", "protein_names_uniprotkb": "Protein phosphatase 1D; 3.1.3.16; PP2C-delta; Protein phosphatase 2C isoform delta; Protein phosphatase magnesium-dependent 1 delta; p53-induced protein phosphatase 1", "protein_names_refseq": "PP2C-delta; p53-induced protein phosphatase 1; protein phosphatase 1D; protein phosphatase magnesium-dependent 1 delta", "tax_id": 10090, "disease": "pre-malignant neoplasm (Disease Ontology:DOID:0060071); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (mmu:53892); (R-MMU-8878166)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10756097;14991053;15327777;21750661;24135283;25428506;31219806;34203471;34428180;36210013;37595362;37709843;38943814", "class_list": "", "function": "Data demonstrate that p53-induced phosphatase PPM1D interacts with the nuclear isoform of uracil DNA glycosylase, UNG2, and suppresses base excision repair., [RefSeq, PubMed]; Inactivation or depletion of the Wip1 phosphatase with resultant p38 MAPK activation suppresses tumor appearance by modulating the Cdkn2a tumor-suppressor locus, [RefSeq, PubMed]; Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation (By similarity). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (PubMed:24135283)., [UniProtKB, UniProtKB, PubMed]; PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy., [RefSeq, PubMed]; Ppm1d truncating mutations promote the development of genotoxic stress-induced AML., [RefSeq, PubMed]; WIP1-mediated regulation of p38 MAPK signaling attenuates pyroptosis in sepsis-associated acute kidney injury., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1B0B0", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051019 mitogen-activated protein kinase binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0000086 G2/M transition of mitotic cell cycle;GO:0009617 response to bacterium;GO:1902531 regulation of intracellular signal transduction;GO:0009267 cellular response to starvation;GO:0045814 negative regulation of gene expression, epigenetic", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9QZ67-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24638-1", "uniprot_id": [ { "id": "PPAL_MOUSE", "url": "https://www.uniprot.org/uniprot/P24638", "type": "external" } ], "mass": 48509.0, "length": 423, "protein_name": "Lysosomal acid phosphatase", "gene_name": "Acp2", "organism": "Mouse", "refseq_name": "lysosomal acid phosphatase isoform 1 precursor", "refseq_ac": [ { "id": "NP_031413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031413", "type": "external" } ], "gene_names_uniprotkb": "Acp2", "gene_names_refseq": "Acp-2; Acp2; LAP", "protein_names_uniprotkb": "Lysosomal acid phosphatase; 3.1.3.2; LAP; Tartrate-inhibitable acid phosphatase", "protein_names_refseq": "lysosomal acid phosphatase isoform 1 precursor; lysosomal acid phosphatase", "tax_id": 10090, "disease": "", "pathway": " (mmu:11432)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;15503243;17868323;19224205;20173027;2059337;21750661;21952136;22158965;30899004;33804256;34428180;35820727;36210013", "class_list": "", "function": "Acp2 is the gene mutated in nax mice provides a valuable model system for studying the role of Acp2 in cerebellum and skin homeostasis., [RefSeq, PubMed]; Lysosomal acid phosphatase that catalyzes the hydrolysis of orthophosphoric monoesters to alcohols and phosphate under acidic conditions (PubMed:15503243). May contribute to the removal of mannose-6-phosphate (Man6P) from lysosomal proteins after their delivery to lysosomes, acting in concert with ACP5 (PubMed:22158965)., [UniProtKB, PubMed, PubMed]; Reduced Granule Cell Proliferation and Molecular Dysregulation in the Cerebellum of Lysosomal Acid Phosphatase 2 (ACP2) Mutant Mice. Publication Status: Online-Only, [RefSeq, PubMed]; The data suggest that lysosomal dysfunction and accumulation of storage material require increased biogenesis of LAP/ACP2 and LAMP-2 positive membranes which makes LAP/ACP2 suitable as biomarker of Batten disease., [RefSeq, PubMed]; The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Two isoforms are predicted to be produced from the same mRNA by the use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017]., [RefSeq]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 12, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q8QZT5", "ec_number_list": [ { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" } ], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0003993 acid phosphatase activity;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0001501 skeletal system development;GO:0007040 lysosome organization;GO:0070305 response to cGMP;GO:0048102 autophagic cell death", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P24638-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61171-1", "uniprot_id": [ { "id": "PRDX2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61171", "type": "external" } ], "mass": 21779.0, "length": 198, "protein_name": "Peroxiredoxin-2", "gene_name": "Prdx2", "organism": "Mouse", "refseq_name": "peroxiredoxin-2", "refseq_ac": [ { "id": "NP_001304314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304314", "type": "external" } ], "gene_names_uniprotkb": "Prdx2; Tdpx1; Tpx", "gene_names_refseq": "Band-8; NkefB; PRP; Prdx2; PrxII; TDX1; TPx-B; TPx; TR; TSA; Tdpx1; Torin", "protein_names_uniprotkb": "Peroxiredoxin-2; 1.11.1.24; TSA; Thiol-specific antioxidant protein; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1; Thioredoxin-dependent peroxiredoxin 2", "protein_names_refseq": "Calpromotin; Prx II-1; Trx dependent peroxide reductase 1; peroxiredoxin-2; protector protein; thiol-specific antioxidant protein; thioredoxin peroxidase 1; thioredoxin reductase; thioredoxin-dependent peroxide reductase 1; thioredoxin-dependent peroxiredoxin 2", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:21672); (R-MMU-3299685); (R-MMU-5628897)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "17141802;21183079;21750661;22645316;33535382;33725478;33727589;34030134;34428180;36288343;36963350;37453647;37507081;38516845;39627609;39927985;9115640;9714804", "class_list": "", "function": "Correlation between PRDX2 and spermatogenesis under oxidative stress., [RefSeq, PubMed]; Intracerebral hemorrhage-induced brain injury in mice: The role of peroxiredoxin 2-Toll-like receptor 4 inflammatory axis., [RefSeq, PubMed]; Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2. Erratum:[Sci Rep. 2021 Sep 14;11(1):18611. doi: 10.1038/s41598-021-98293-1. PMID: 34521981] Publication Status: Online-Only, [RefSeq, PubMed]; Peroxiredoxin II with dermal mesenchymal stem cells accelerates wound healing., [RefSeq, PubMed]; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88376;Q60796;Q9CWJ4;Q9DB49", "ec_number_list": [ { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0016209 antioxidant activity;GO:0008379 thioredoxin peroxidase activity;GO:0004601 peroxidase activity;GO:0008430 selenium binding;GO:0140824 thioredoxin-dependent peroxiredoxin activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0043209 myelin sheath;GO:0005737 cytoplasm", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0032496 response to lipopolysaccharide;GO:0043410 positive regulation of MAPK cascade;GO:0043524 negative regulation of neuron apoptotic process;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q61171-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCL9-1", "uniprot_id": [ { "id": "PUR6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCL9", "type": "external" } ], "mass": 47006.0, "length": 425, "protein_name": "Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase", "gene_name": "Paics", "organism": "Mouse", "refseq_name": "bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform a", "refseq_ac": [ { "id": "NP_080215", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080215", "type": "external" } ], "gene_names_uniprotkb": "Paics", "gene_names_refseq": "2610511I09Rik; ADE2H1; AIRC; PAIS; Paics", "protein_names_uniprotkb": "Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase; AIR carboxylase; AIRC; PAICS; SAICAR synthetase", "protein_names_refseq": "bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform a; bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase; multifunctional protein ADE2", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:67054); (R-MMU-73817)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;19131326;21540332;21750661;22645316;22872234;23806337;24788674;25153642;25428506;26740625;28528544;34428180;37453647;37507081;39927985", "class_list": "", "function": "Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQ38", "ec_number_list": [ { "id": "4.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.21", "type": "external" }, { "id": "6.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.6", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity;GO:0004638 phosphoribosylaminoimidazole carboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006177 GMP biosynthetic process;GO:0009113 purine nucleobase biosynthetic process;GO:0006189 'de novo' IMP biosynthetic process;GO:0044208 'de novo' AMP biosynthetic process;GO:0097294 'de novo' XMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9DCL9-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q922U1-1", "uniprot_id": [ { "id": "PRPF3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q922U1", "type": "external" } ], "mass": 77455.0, "length": 683, "protein_name": "U4/U6 small nuclear ribonucleoprotein Prp3", "gene_name": "Prpf3", "organism": "Mouse", "refseq_name": "U4/U6 small nuclear ribonucleoprotein Prp3", "refseq_ac": [ { "id": "NP_001303680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303680", "type": "external" } ], "gene_names_uniprotkb": "Prpf3", "gene_names_refseq": "3632413F13Rik; Prpf3", "protein_names_uniprotkb": "U4/U6 small nuclear ribonucleoprotein Prp3; Pre-mRNA-splicing factor 3", "protein_names_refseq": "PRP3 pre-mRNA processing factor 3 homolog; U4/U6 small nuclear ribonucleoprotein Prp3; pre-mRNA-splicing factor 3", "tax_id": 10090, "disease": "retinitis pigmentosa 18 (Disease Ontology:DOID:0110356); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:70767); (R-MMU-72163)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "18395097;20811066;21183079;21283520;21750661;25111227;25428506;31219806;34428180;37828378", "class_list": "", "function": "Analyzed the spatial and temporal expression of the PRPF3 gene in mice and found that it is highly expressed in retinal cells relative to other tissues and its expression is developmentally regulated Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TASP1, EPS15R, and PRPF3 expression were significantly induced in HCCs of transgenic EGF2B mice as was P2 promoter-driven HNF4alpha, [RefSeq, PubMed]; The finding of similar degenerative changes in RPE cells of all three mouse models suggests that the retinal pigment epithelium may be the primary cell type affected in the RNA splicing factor forms of retinitis pigmentosa. Publication Status: Online-Only, [RefSeq, PubMed]; The mouse retinal pigment epithelium (RPE)is the primary cell affected by mutations in the RNA splicing factors (PRPF3, PRPF8, and PRPF31), and these changes occur at an early age., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJH4;Q9D6C6", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q922U1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0W5-1", "uniprot_id": [ { "id": "PPIL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0W5", "type": "external" } ], "mass": 18237.0, "length": 166, "protein_name": "Peptidyl-prolyl cis-trans isomerase-like 1", "gene_name": "Ppil1", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase-like 1", "refseq_ac": [ { "id": "NP_081121", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081121", "type": "external" } ], "gene_names_uniprotkb": "Ppil1", "gene_names_refseq": "1110060O10Rik; Cypl1; Ppil1", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase-like 1; 5.2.1.8; PPIase; Rotamase PPIL1", "protein_names_refseq": "PPIase; peptidyl-prolyl cis-trans isomerase-like 1; rotamase PPIL1", "tax_id": 10090, "disease": "pontocerebellar hypoplasia type 14 (Disease Ontology:DOID:0112325); microcephaly (Disease Ontology:DOID:10907)", "pathway": " (mmu:68816); (R-MMU-72163)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;33220177", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the spliceosome (PubMed:33220177). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Catalyzes prolyl peptide bond isomerization in CDC40/PRP17 (By similarity). Plays an important role in embryonic brain development; this function is independent of its isomerase activity (PubMed:33220177)., [UniProtKB, UniProtKB, PubMed]; Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UA03", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0097718 disordered domain specific binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0071014 post-mRNA release spliceosomal complex", "go_biological_process": "GO:0006457 protein folding;GO:0000398 mRNA splicing, via spliceosome;GO:1990403 embryonic brain development;GO:0000413 protein peptidyl-prolyl isomerization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D0W5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJY1-1", "uniprot_id": [ { "id": "PSMD5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJY1", "type": "external" } ], "mass": 55972.0, "length": 504, "protein_name": "26S proteasome non-ATPase regulatory subunit 5", "gene_name": "Psmd5", "organism": "Mouse", "refseq_name": "26S proteasome non-ATPase regulatory subunit 5 isoform 1", "refseq_ac": [ { "id": "NP_542121", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542121", "type": "external" } ], "gene_names_uniprotkb": "Psmd5; Kiaa0072", "gene_names_refseq": "1500032A03Rik; Psmd5; S5b; mKIAA0072", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 5; 26S protease subunit S5 basic; 26S proteasome subunit S5B", "protein_names_refseq": "26S protease subunit S5 basic; 26S proteasome non-ATPase regulatory subunit 5 isoform 1; 26S proteasome non-ATPase regulatory subunit 5; 26S proteasome subunit S5B", "tax_id": 10090, "disease": "", "pathway": " (mmu:66998); (R-MMU-9907900)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16857966;21750661;22921402;26495903;29716915;35820727", "class_list": "", "function": "Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5 (By similarity)., [UniProtKB]; Study in HT-29 cells and mouse colorectal tumor models revealed that levels of the proteasome assembly inhibitor PSMD5/S5B are significantly decreased in tumors, and re-expression of PSMD5 blocks 26S proteasome assembly. These results suggest that intestinal cancer cells escape proteotoxic stress by reducing PSMD5 to stimulate 26S proteasome assembly., [RefSeq, PubMed]; The critical role of S5b/PSMD5 in negative regulation of proteasome by TNF-alpha/NFkappaB and provide insights into proteasome inhibition in human disease., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AUB0;Q3UFV2;Q5DU49;Q8BMA9;Q8VEE9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0022624 proteasome accessory complex", "go_biological_process": "GO:0070682 proteasome regulatory particle assembly;GO:0043248 proteasome assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BJY1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPS2-1", "uniprot_id": [ { "id": "PYY_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EPS2", "type": "external" } ], "mass": 11064.0, "length": 98, "protein_name": "Peptide YY", "gene_name": "Pyy", "organism": "Mouse", "refseq_name": "peptide YY isoform 1 precursor", "refseq_ac": [ { "id": "NP_663410", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663410", "type": "external" } ], "gene_names_uniprotkb": "Pyy", "gene_names_refseq": "Pyy", "protein_names_uniprotkb": "Peptide YY; PYY-II; PYY; Peptide tyrosine tyrosine", "protein_names_refseq": "Peptide tyrosine tyrosine; peptide YY isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:217212); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12167864;16280589;21457230;21750661;30084848;37995867", "class_list": "", "function": "Is a NPY2R agonist involved in the down-regulation of appetite and food intake, probably acting on receptors located on proopiomelanocortin(POMC)-releasing and neuropeptide Y(NPY)-releasing neurons in the arcuate nucleus of hypothalamus (PubMed:12167864, PubMed:16280589). In NPY-releasing neurons, NPY2R activation by PYY(3-36) leads to membrane hyperpolarization and reduced release of the orexigenic neuropeptide NPY (PubMed:16280589)., [UniProtKB, PubMed, PubMed]; Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NPY2R). Also binds NPY5R. Receptor binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by PYY also leads to an increase of intracellular Ca(2+) levels (By similarity). This gut peptide inhibits exocrine pancreatic secretion (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (PubMed:21457230)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release From Enteroendocrine Cells., [RefSeq, PubMed]; This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91XD0", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0048018 receptor ligand activity;GO:0031841 neuropeptide Y receptor binding;GO:0001664 G protein-coupled receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1903999 negative regulation of eating behavior;GO:0007218 neuropeptide signaling pathway;GO:0042755 eating behavior;GO:0007631 feeding behavior;GO:1904456 negative regulation of neuronal action potential", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9EPS2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35256-1", "uniprot_id": [ { "id": "PR4A1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35256", "type": "external" } ], "mass": 26336.0, "length": 227, "protein_name": "Prolactin-4A1", "gene_name": "Prl4a1", "organism": "Mouse", "refseq_name": "prolactin-4A1 precursor", "refseq_ac": [ { "id": "NP_035295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035295", "type": "external" } ], "gene_names_uniprotkb": "Prl4a1; Prlpa", "gene_names_refseq": "Ghd23; PLP-A; Prl4a1; Prlpa", "protein_names_uniprotkb": "Prolactin-4A1; PLP-A; PRL-like protein A; Placental prolactin-like protein A", "protein_names_refseq": "PRL-like protein A; growth hormone d23; placental prolactin-like protein A; prolactin-4A1 precursor; prolactin-4A1", "tax_id": 10090, "disease": "", "pathway": " (mmu:19110)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15545614;20485683;9389542;9472921", "class_list": "", "function": "PLP-A contributes to hypoxia-induced adaptations critical to hemochorial placentation and thus nutrient flow to extraembryonic and embryonic tissues., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0001666 response to hypoxia;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35256-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35257-1", "uniprot_id": [ { "id": "PR6A1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35257", "type": "external" } ], "mass": 26621.0, "length": 230, "protein_name": "Prolactin-6A1", "gene_name": "Prl6a1", "organism": "Mouse", "refseq_name": "prolactin-6A1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_035296", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035296", "type": "external" } ], "gene_names_uniprotkb": "Prl6a1; Prlpb", "gene_names_refseq": "Ghd10; PLP-B; Prl6a1; Prlpb", "protein_names_uniprotkb": "Prolactin-6A1; PLP-B; PRL-like protein B; Placental prolactin-like protein B", "protein_names_refseq": "PRL-like protein B; growth hormone d10; placental prolactin-like protein B; prolactin-6A1 isoform 1 precursor; prolactin-6A1", "tax_id": 10090, "disease": "", "pathway": " (mmu:19111)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;9389542;9472921", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O35257-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35449-1", "uniprot_id": [ { "id": "PRRT1_MOUSE", "url": "https://www.uniprot.org/uniprot/O35449", "type": "external" } ], "mass": 31389.0, "length": 306, "protein_name": "Proline-rich transmembrane protein 1", "gene_name": "Prrt1", "organism": "Mouse", "refseq_name": "proline-rich transmembrane protein 1 isoform 1", "refseq_ac": [ { "id": "NP_112152", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112152", "type": "external" } ], "gene_names_uniprotkb": "Prrt1; Ng5", "gene_names_refseq": "Bat-4; Bat4; D17H6S54E; DSPD1; G5b; NG5; ORF31; Prrt1; SynDIG4", "protein_names_uniprotkb": "Proline-rich transmembrane protein 1; DSPD1; Dispanin subfamily D member 1; SynDIG4; Synapse differentiation-induced protein 4", "protein_names_refseq": "dispanin subfamily D member 1; proline-rich transmembrane protein 1 isoform 1; synapse differentiation-induced protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:260297)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14656967;22363774;22632720;25605945;29490264;30084848;31216424", "class_list": "", "function": "PRRT1 controls NMDA-induced trafficking of AMPA receptors in hippocampal neurons., [RefSeq, PubMed]; Required to maintain a pool of extrasynaptic AMPA-regulated glutamate receptors (AMPAR) which is necessary for synapse development and function (PubMed:29490264). Regulates AMPAR function and synaptic transmission during development but is dispensable at mature hippocampal synapses (PubMed:29490264, PubMed:31216424). Plays a role in regulating basal phosphorylation levels of glutamate receptor GRIA1 and promotes GRIA1 and GRIA2 cell surface expression (PubMed:31216424)., [UniProtKB, PubMed, PubMed]; SynDIG4 maintains a pool of extrasynaptic AMPARs necessary for synapse development and function underlying higher-order cognitive plasticity., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0030545 signaling receptor regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0045211 postsynaptic membrane;GO:0030672 synaptic vesicle membrane;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007611 learning or memory;GO:0050808 synapse organization;GO:0060292 long-term synaptic depression;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O35449-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54831-1", "uniprot_id": [ { "id": "PR7A2_MOUSE", "url": "https://www.uniprot.org/uniprot/O54831", "type": "external" } ], "mass": 28921.0, "length": 253, "protein_name": "Prolactin-7A2", "gene_name": "Prl7a2", "organism": "Mouse", "refseq_name": "prolactin-7A2 precursor", "refseq_ac": [ { "id": "NP_035298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035298", "type": "external" } ], "gene_names_uniprotkb": "Prl7a2; Prlpf", "gene_names_refseq": "Ghd18; PLP-F; Prl7a2; Prlpf", "protein_names_uniprotkb": "Prolactin-7A2; PLP-F; PRL-like protein F; Placental prolactin-like protein F", "protein_names_refseq": "PRL-like protein F; growth hormone d18; placental prolactin-like protein F; prolactin-7A2 precursor; prolactin-7A2", "tax_id": 10090, "disease": "", "pathway": " (mmu:19114)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12399423;9389541", "class_list": "", "function": "Results show that PRL-like proteins E and F have the same stimulatory effects on megakaryocyte growth and differentiation, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O54831-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04769-1", "uniprot_id": [ { "id": "PR7D1_MOUSE", "url": "https://www.uniprot.org/uniprot/P04769", "type": "external" } ], "mass": 27952.0, "length": 244, "protein_name": "Prolactin-7D1", "gene_name": "Prl7d1", "organism": "Mouse", "refseq_name": "prolactin-7D1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_035250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035250", "type": "external" } ], "gene_names_uniprotkb": "Prl7d1; Plfr", "gene_names_refseq": "Ghd19; PLF-RP; PRP; Plfr; Prl7d1", "protein_names_uniprotkb": "Prolactin-7D1; PRP; Proliferin-related protein", "protein_names_refseq": "growth hormone d19; prolactin-7D1 isoform 1 precursor; prolactin-7D1; proliferin-related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:18814)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26771609;31012985;4029117", "class_list": "", "function": "PRL7D1 overexpression could lead to increased germ cell apoptosis and exert an inhibitory effect on testosterone production in Leydig cells by reducing the expression of certain steroidogenic-related genes. Publication Status: Online-Only, [RefSeq, PubMed]; Together, this study demonstrates that Prl7d1 possesses antiangiogenic properties in deciduas and inhibits the development of junctional zone, which potentially alters the functional capacity of the placenta to support optimal fetal growth., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005125 cytokine activity;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0001890 placenta development;GO:0007565 female pregnancy;GO:0043537 negative regulation of blood vessel endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P04769-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06879-1", "uniprot_id": [ { "id": "PRL_MOUSE", "url": "https://www.uniprot.org/uniprot/P06879", "type": "external" } ], "mass": 25496.0, "length": 226, "protein_name": "Prolactin", "gene_name": "Prl", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prl", "gene_names_refseq": "", "protein_names_uniprotkb": "Prolactin; PRL", "protein_names_refseq": "", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); portal hypertension (Disease Ontology:DOID:10762); impulse control disorder (Disease Ontology:DOID:10937); hyperprolactinemia (Disease Ontology:DOID:12700); renovascular hypertension (Disease Ontology:DOID:1591); depressive disorder (Disease Ontology:DOID:1596); severe acute respiratory syndrome (Disease Ontology:DOID:2945); carotid artery disease (Disease Ontology:DOID:3407); prolactinoma (Disease Ontology:DOID:5394); hepatocellular carcinoma (Disease Ontology:DOID:684); cocaine abuse (Disease Ontology:DOID:809); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (R-MMU-1170546); (R-MMU-982772)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "2991252;3756168", "class_list": "", "function": "Prolactin acts primarily on the mammary gland by promoting lactation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q544X8", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0046425 regulation of receptor signaling pathway via JAK-STAT;GO:0007166 cell surface receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P06879-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C5E4-1", "uniprot_id": [ { "id": "PTPRQ_MOUSE", "url": "https://www.uniprot.org/uniprot/P0C5E4", "type": "external" } ], "mass": 256785.0, "length": 2300, "protein_name": "Phosphatidylinositol phosphatase PTPRQ", "gene_name": "Ptprq", "organism": "Mouse", "refseq_name": "phosphatidylinositol phosphatase PTPRQ isoform 2 precursor", "refseq_ac": [ { "id": "NP_001074901", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074901", "type": "external" } ], "gene_names_uniprotkb": "Ptprq", "gene_names_refseq": "Ptprq; R-PTP-Q", "protein_names_uniprotkb": "Phosphatidylinositol phosphatase PTPRQ; 3.1.3.36; 3.1.3.67; 3.1.3.86; 3.1.3.95; PTP-RQ; R-PTP-Q; Receptor-type tyrosine-protein phosphatase Q", "protein_names_refseq": "phosphatidylinositol phosphatase PTPRQ isoform 2 precursor; phosphatidylinositol phosphatase PTPRQ; phosphotidylinositol phosphatase PTPRQ", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 73 (Disease Ontology:DOID:0080269); autosomal recessive nonsyndromic deafness 84A (Disease Ontology:DOID:0110529)", "pathway": " (mmu:237523)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14534255;24285636;24446963;31219806;34203471;34428180;37952086;39627609", "class_list": "", "function": "Dephosphorylates phosphatidylinositol phosphates, such as phosphatidylinositol 3,4,5-trisphosphate (PIP3) and phosphatidylinositol 3,5-diphosphates, with preference for PIP3. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity in vitro; however, the relevance of such activity in vivo is unclear (By similarity). Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by regulating the levels of PIP3 in MSCs and preadipocyte cells (By similarity). Required for hair bundle maturation, a process that enables hair cells to detect and transmit sound and balance signals effectively, therefore affecting auditory function (PubMed:14534255). May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles (Probable)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Ptprq is required for formation of the shaft connectors of the hair bundle, the normal maturation of cochlear hair bundles, and the long-term survival of high-frequency auditory hair cells, [RefSeq, PubMed]; The reduction in Ptprq observed in miR-96 mutantdiminuendo mice appears to be a major contributor to the morphological, transcriptional and electrophysiological phenotype, [RefSeq, PubMed]", "predicted_glycosites": 16, "predicted_n_glycosites": 16, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" } ], "go_molecular_function": "GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity;GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity;GO:0004725 protein tyrosine phosphatase activity;GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity;GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0043235 receptor complex;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane;GO:0032421 stereocilium bundle;GO:0120044 stereocilium base", "go_biological_process": "GO:0042472 inner ear morphogenesis;GO:0050885 neuromuscular process controlling balance;GO:0050910 detection of mechanical stimulus involved in sensory perception of sound;GO:0002244 hematopoietic progenitor cell differentiation;GO:0060116 vestibular receptor cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P0C5E4-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11680-1", "uniprot_id": [ { "id": "PROP_MOUSE", "url": "https://www.uniprot.org/uniprot/P11680", "type": "external" } ], "mass": 50327.0, "length": 464, "protein_name": "Properdin", "gene_name": "Cfp", "organism": "Mouse", "refseq_name": "properdin precursor", "refseq_ac": [ { "id": "NP_032849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032849", "type": "external" } ], "gene_names_uniprotkb": "Cfp; Pfc", "gene_names_refseq": "BCFG; Cfp; Pfc", "protein_names_uniprotkb": "Properdin; Complement factor P", "protein_names_refseq": "complement factor P; properdin factor, complement; properdin precursor", "tax_id": 10090, "disease": "X-linked properdin deficiency (Disease Ontology:DOID:0111768); factor VIII deficiency (Disease Ontology:DOID:12134)", "pathway": " (mmu:18636); (R-MMU-173736); (R-MMU-174577); (R-MMU-5173214); (R-MMU-6798695); (R-MMU-977606)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "28264884;3045564;34552582;37207230;37951917", "class_list": "", "function": "A positive regulator of the alternate pathway of complement (PubMed:28264884). It binds to and stabilizes the C3- and C5-convertase enzyme complexes (By similarity). Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b) (By similarity)., [UniProtKB, PubMed, UniProtKB]; HBSP improves kidney ischemia-reperfusion injury and promotes repair in properdin deficient mice via enhancing phagocytosis of tubular epithelial cells. Erratum:[Front Immunol. 2023 Jun 29;14:1242436. doi: 10.3389/fimmu.2023.1242436. PMID: 37457728] Publication Status: Online-Only, [RefSeq, PubMed]; Infiltrating myeloid cell-derived properdin markedly promotes microglia-mediated neuroinflammation after ischemic stroke. Publication Status: Online-Only, [RefSeq, PubMed]; Properdin Deficiency Impairs Phagocytosis and Enhances Injury at Kidney Repair Phase Post Ischemia-Reperfusion. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 20, "predicted_n_glycosites": 1, "predicted_o_glycosites": 4, "predicted_c_glycosites": 15, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "Q3TB98;Q3U779", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0098548 cytoplasmic side of Golgi membrane", "go_biological_process": "GO:0050821 protein stabilization;GO:0050778 positive regulation of immune response;GO:0006956 complement activation;GO:1903028 positive regulation of opsonization;GO:0006957 complement activation, alternative pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P11680-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000011100.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15499-1", "uniprot_id": [ { "id": "PRPH2_MOUSE", "url": "https://www.uniprot.org/uniprot/P15499", "type": "external" } ], "mass": 39260.0, "length": 346, "protein_name": "Peripherin-2", "gene_name": "Prph2", "organism": "Mouse", "refseq_name": "peripherin-2", "refseq_ac": [ { "id": "NP_032964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032964", "type": "external" } ], "gene_names_uniprotkb": "Prph2; Rds", "gene_names_refseq": "AOFMD; AVMD; Nmf193; PRPH; Prph2; RP7; Rd-2; Rd2; Rds; Tspan22; rds", "protein_names_uniprotkb": "Peripherin-2; Retinal degeneration slow protein", "protein_names_refseq": "peripherin-2; retinal degeneration 2; retinal degeneration slow protein; retinal degeneration, slow (retinitis pigmentosa 7)", "tax_id": 10090, "disease": "vitelliform macular dystrophy (Disease Ontology:DOID:0050661); patterned macular dystrophy (Disease Ontology:DOID:0060863); patterned macular dystrophy 1 (Disease Ontology:DOID:0060866); retinitis pigmentosa 7 (Disease Ontology:DOID:0110383); retinitis pigmentosa (Disease Ontology:DOID:10584); fundus albipunctatus (Disease Ontology:DOID:11105); Leber congenital amaurosis (Disease Ontology:DOID:14791); macular degeneration (Disease Ontology:DOID:4448); retinal disease (Disease Ontology:DOID:5679); retinal degeneration (Disease Ontology:DOID:8466); choroidal sclerosis (Disease Ontology:DOID:980); partial central choroid dystrophy (Disease Ontology:DOID:9822)", "pathway": " (mmu:19133)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10802659;17260955;1992463;25428506;26406599;2918924;29961824;37914688;37991486;38834544;6715580;8530028", "class_list": "", "function": "Downregulation of rhodopsin is an effective therapeutic strategy in ameliorating peripherin-2-associated inherited retinal disorders. Erratum:[Nat Commun. 2024 Jul 19;15(1):6091. doi: 10.1038/s41467-024-50140-3. PMID: 39030161] Publication Status: Online-Only, [RefSeq, PubMed]; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (PubMed:6715580). Required for the maintenance of retinal outer nuclear layer thickness (PubMed:29961824, PubMed:6715580). Required for the correct development and organization of the photoreceptor inner segment (PubMed:6715580)., [UniProtKB, PubMed, PubMed]; Prph2 knock-in mice recapitulate human central areolar choroidal dystrophy retinal degeneration and exhibit aberrant synaptic remodeling and microglial activation. Publication Status: Online-Only, [RefSeq, PubMed]; ROM1 is redundant to PRPH2 as a molecular building block of photoreceptor disc rims. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0009645 response to low light intensity stimulus;GO:0007155 cell adhesion;GO:0051260 protein homooligomerization;GO:0051291 protein heterooligomerization;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P15499-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16646-1", "uniprot_id": [ { "id": "PMP22_MOUSE", "url": "https://www.uniprot.org/uniprot/P16646", "type": "external" } ], "mass": 18023.0, "length": 161, "protein_name": "Peripheral myelin protein 22", "gene_name": "Pmp22", "organism": "Mouse", "refseq_name": "peripheral myelin protein 22 isoform 1", "refseq_ac": [ { "id": "NP_001289184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289184", "type": "external" } ], "gene_names_uniprotkb": "Pmp22; Gas-3; Gas3; Pmp-22", "gene_names_refseq": "Gas-3; HNPP; PMP-22; Pmp22; TRE002; Tr; trembler", "protein_names_uniprotkb": "Peripheral myelin protein 22; GAS-3; Growth arrest-specific protein 3; PMP-22", "protein_names_refseq": "growth arrest-specific protein 3; peripheral myelin protein 22 isoform 1; peripheral myelin protein, 22 kDa", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease type 3 (Disease Ontology:DOID:0050540); small intestine carcinoid neuroendocrine tumor (Disease Ontology:DOID:0050925); hereditary neuropathy with liability to pressure palsies (Disease Ontology:DOID:0060843); Charcot-Marie-Tooth disease type 1A (Disease Ontology:DOID:0110148); Charcot-Marie-Tooth disease type 1E (Disease Ontology:DOID:0110153); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); sciatic neuropathy (Disease Ontology:DOID:11446); Guillain-Barre syndrome (Disease Ontology:DOID:12842)", "pathway": " (mmu:18858)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1374899;1552943;1692961;21750661;30773261;35178836;38743588", "class_list": "", "function": "Might be involved in growth regulation, and in myelinization in the peripheral nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PMP22 duplication dysregulates lipid homeostasis and plasma membrane organization in developing human Schwann cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91XF9", "ec_number_list": [], "go_molecular_function": "GO:0003774 cytoskeletal motor activity;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0009986 cell surface;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0031579 membrane raft organization;GO:0060005 vestibular reflex;GO:0048936 peripheral nervous system neuron axonogenesis;GO:2001233 regulation of apoptotic signaling pathway;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P16646-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21952-1", "uniprot_id": [ { "id": "PO3F1_MOUSE", "url": "https://www.uniprot.org/uniprot/P21952", "type": "external" } ], "mass": 45324.0, "length": 449, "protein_name": "POU domain, class 3, transcription factor 1", "gene_name": "Pou3f1", "organism": "Mouse", "refseq_name": "POU domain, class 3, transcription factor 1", "refseq_ac": [ { "id": "NP_035271", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035271", "type": "external" } ], "gene_names_uniprotkb": "Pou3f1; Oct6; Otf-6; Otf6; Scip", "gene_names_refseq": "Oct-6; Oct6; Otf-6; Otf6; Pou3f1; Scip; Test1; Tst-1; Tst1", "protein_names_uniprotkb": "POU domain, class 3, transcription factor 1; OTF-6; Oct-6; Octamer-binding protein 6; Octamer-binding transcription factor 6; POU domain transcription factor SCIP", "protein_names_refseq": "POU domain transcription factor SCIP; POU domain, class 3, transcription factor 1; octamer binding factor oct6; octamer-binding protein 6; octamer-binding transcription factor 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:18991)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10068633;1565620;1840678;18505825;1976514;1979677;30084848", "class_list": "", "function": "Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:1976514, PubMed:1979677). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (PubMed:18505825). Acts as a transcriptional repressor of myelin-specific genes (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P21952-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33587-1", "uniprot_id": [ { "id": "PROC_MOUSE", "url": "https://www.uniprot.org/uniprot/P33587", "type": "external" } ], "mass": 51818.0, "length": 460, "protein_name": "Vitamin K-dependent protein C", "gene_name": "Proc", "organism": "Mouse", "refseq_name": "vitamin K-dependent protein C isoform 2 preproprotein", "refseq_ac": [ { "id": "NP_001036232", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036232", "type": "external" } ], "gene_names_uniprotkb": "Proc", "gene_names_refseq": "PC; Proc", "protein_names_uniprotkb": "Vitamin K-dependent protein C; 3.4.21.69; Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV", "protein_names_refseq": "anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; inactivator of coagulation factors Va, VIII; vitamin K-dependent protein C isoform 2 preproprotein; vitamin K-dependent protein C", "tax_id": 10090, "disease": "thrombosis (Disease Ontology:DOID:0060903); thrombophilia due to activated protein C resistance (Disease Ontology:DOID:0111902); autosomal recessive thrombophilia due to protein C deficiency (Disease Ontology:DOID:0111904); autosomal dominant thrombophilia due to protein C deficiency (Disease Ontology:DOID:0111909); osteonecrosis (Disease Ontology:DOID:10159); pre-eclampsia (Disease Ontology:DOID:10591); thrombotic thrombocytopenic purpura (Disease Ontology:DOID:10772); disseminated intravascular coagulation (Disease Ontology:DOID:11247); toxic shock syndrome (Disease Ontology:DOID:14115); central retinal vein occlusion (Disease Ontology:DOID:2450); thrombophilia (Disease Ontology:DOID:2452); asthma (Disease Ontology:DOID:2841); antiphospholipid syndrome (Disease Ontology:DOID:2988); acute kidney failure (Disease Ontology:DOID:3021); protein C deficiency (Disease Ontology:DOID:3756); myocardial infarction (Disease Ontology:DOID:5844); pulmonary embolism (Disease Ontology:DOID:9477); placental abruption (Disease Ontology:DOID:9667)", "pathway": " (mmu:19123); (R-MMU-159740); (R-MMU-159763); (R-MMU-159782); (R-MMU-202733); (R-MMU-381426); (R-MMU-8957275); (R-MMU-9769733); (R-MMU-9769739); (R-MMU-9769743)", "pathway_count": 10, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;1618739;16944957;21750661;30865333;34428180;34930019;35008942;8043441;9493582", "class_list": "", "function": "APC inhibits LPS-mediated cytoplasmic translocation and secretion of HMGB1 in endothelial cells by epigenetic mechanisms, [RefSeq, PubMed]; Activated Protein C Protects against Murine Contact Dermatitis by Suppressing Protease-Activated Receptor 2. Publication Status: Online-Only, [RefSeq, PubMed]; Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging. Erratum:[Circ Res. 2022 Jun 24;131(1):e1. doi: 10.1161/RES.0000000000000556. PMID: 35737758], [RefSeq, PubMed]; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (By similarity). Exerts a protective effect on the endothelial cell barrier function (By similarity)., [UniProtKB, UniProtKB]; This gene encodes the vitamin K-dependent protein C, which plays a vital role in the anticoagulation pathway. The encoded protein undergoes proteolytic processing including activation by thrombin-thrombomodulin complex to form the anticoagulant serine protease that degrades activated coagulation factors. A complete lack of the encoded protein in mice results in severe perinatal consumptive coagulopathy in the brain and liver, resulting in death within 24 hours after birth. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature protein. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 18, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O35498;Q91WN8;Q99PC6", "ec_number_list": [ { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.4.21.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.5", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.1.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.98", "type": "external" }, { "id": "3.4.21.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.27", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "4.1.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.90", "type": "external" }, { "id": "3.4.21.112", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.112", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0008233 peptidase activity;GO:0070012 oligopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:1905370 serine-type endopeptidase complex;GO:0005576 extracellular region", "go_biological_process": "GO:0044537 regulation of circulating fibrinogen levels;GO:0001889 liver development;GO:0006508 proteolysis;GO:0043066 negative regulation of apoptotic process;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P33587-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35821-1", "uniprot_id": [ { "id": "PTN1_MOUSE", "url": "https://www.uniprot.org/uniprot/P35821", "type": "external" } ], "mass": 49593.0, "length": 432, "protein_name": "Tyrosine-protein phosphatase non-receptor type 1", "gene_name": "Ptpn1", "organism": "Mouse", "refseq_name": "tyrosine-protein phosphatase non-receptor type 1", "refseq_ac": [ { "id": "NP_035331", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035331", "type": "external" } ], "gene_names_uniprotkb": "Ptpn1", "gene_names_refseq": "PTP-1B; PTP-HA2; PTP1B; Ptpn1", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 1; 3.1.3.48; PTP-1B; PTP-HA2; Protein-tyrosine phosphatase 1B; Protein-tyrosine phosphatase HA2", "protein_names_refseq": "protein-protein-tyrosine phosphatase HA2; protein-tyrosine phosphatase 1B; tyrosine-protein phosphatase non-receptor type 1", "tax_id": 10090, "disease": "intestinal cancer (Disease Ontology:DOID:10155); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); hyperinsulinism (Disease Ontology:DOID:2018); coronary artery disease (Disease Ontology:DOID:3393); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:19246); (R-MMU-354192); (R-MMU-6807004); (R-MMU-77387); (R-MMU-8849472); (R-MMU-912694); (R-MMU-982772); (R-MMU-9860927)", "pathway_count": 8, "publication_count": 10, "publication_id_list": "11579209;1378268;15226396;17242355;1932742;21183079;28528544;34428180;38563147;7832766", "class_list": "", "function": "Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous Thromboinflammation., [RefSeq, PubMed]; Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60840;Q62131;Q64498;Q99JS1", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005158 insulin receptor binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0005769 early endosome", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:0016311 dephosphorylation;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:2000646 positive regulation of receptor catabolic process;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P35821-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46664-1", "uniprot_id": [ { "id": "PURA2_MOUSE", "url": "https://www.uniprot.org/uniprot/P46664", "type": "external" } ], "mass": 50021.0, "length": 456, "protein_name": "Adenylosuccinate synthetase isozyme 2", "gene_name": "Adss2", "organism": "Mouse", "refseq_name": "adenylosuccinate synthetase isozyme 2 isoform 1", "refseq_ac": [ { "id": "NP_031448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031448", "type": "external" } ], "gene_names_uniprotkb": "Adss2; Adss", "gene_names_refseq": "AS; Adss2; Adss; adSS 2", "protein_names_uniprotkb": "Adenylosuccinate synthetase isozyme 2; 6.3.4.4; AMPSase 2; AdSS 2; Adenylosuccinate synthetase, acidic isozyme; Adenylosuccinate synthetase, liver isozyme; IMP--aspartate ligase 2; L-type adenylosuccinate synthetase", "protein_names_refseq": "AMPSase 2; IMP--aspartate ligase 2; L-type adenylosuccinate synthetase; adenylosuccinate synthetase 2, non muscle; adenylosuccinate synthetase isozyme 2 isoform 1; adenylosuccinate synthetase isozyme 2; adenylosuccinate synthetase, acidic isozyme; adenylosuccinate synthetase, liver isozyme; adenylosuccinate synthetase, non muscle; adenylosuccinate synthetase, non-muscle isozyme", "tax_id": 10090, "disease": "sarcoma (Disease Ontology:DOID:1115)", "pathway": " (mmu:11566); (R-MMU-73817)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12482871;21952136;22872234;25153642;25605945;26740625;28135057;31219806;34428180;35820727;36210013;8308018", "class_list": "", "function": "Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQL9", "ec_number_list": [ { "id": "6.3.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.4", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005525 GTP binding;GO:0004019 adenylosuccinate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0014074 response to purine-containing compound;GO:0046040 IMP metabolic process;GO:0006531 aspartate metabolic process;GO:0044209 AMP salvage;GO:0071257 cellular response to electrical stimulus", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P46664-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VBB0-1", "uniprot_id": [ { "id": "PRLD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0VBB0", "type": "external" } ], "mass": 20420.0, "length": 177, "protein_name": "PRELI domain-containing protein 2", "gene_name": "Prelid2", "organism": "Mouse", "refseq_name": "PRELI domain-containing protein 2", "refseq_ac": [ { "id": "NP_084218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084218", "type": "external" } ], "gene_names_uniprotkb": "Prelid2", "gene_names_refseq": "1700003A01Rik; C330008K14Rik; Prelid2", "protein_names_uniprotkb": "PRELI domain-containing protein 2", "protein_names_refseq": "PRELI domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:77619)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19847657;31219806", "class_list": "", "function": "The PRELI domain containing 2 gene is involved in mouse embryonic development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CRD8", "ec_number_list": [], "go_molecular_function": "GO:1990050 phosphatidic acid transfer activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0015914 phospholipid transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0VBB0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q14A28-1", "uniprot_id": [ { "id": "PROK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q14A28", "type": "external" } ], "mass": 11678.0, "length": 105, "protein_name": "Prokineticin-1", "gene_name": "Prok1", "organism": "Mouse", "refseq_name": "prokineticin-1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001037847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037847", "type": "external" } ], "gene_names_uniprotkb": "Prok1; Pk1", "gene_names_refseq": "EG-VEGF; Prok1", "protein_names_uniprotkb": "Prokineticin-1; EG-VEGF; Endocrine-gland-derived vascular endothelial growth factor", "protein_names_refseq": "endocrine-gland-derived vascular endothelial growth factor; prokineticin-1 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:246691); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12604792;12746324;17324478;17531315;26081281;29197014", "class_list": "", "function": "Bv8 and EG-VEGF, along with other factors such as VEGF-A, may maintain the integrity and also regulate proliferation of the blood vessels in the testis, [RefSeq, PubMed]; Clinical studies strongly suggested the potential involvement of the new angiogenic factor EG-VEGF in pregnancy-induced hypertension. Here is described the protocol that served to demonstrate that maintenance of EG-VEGF production over 11.5 days post coitus (dpc) in the gravid mice caused the development of pregnancy-induced hypertension. Erratum:[Methods Mol Biol. 2018;1710:E1. doi: 10.1007/978-1-4939-7498-6_29. PMID: 29704221], [RefSeq, PubMed]; EG-VEGF is a new mediator of PPARgamma effects during pregnancy and bring new insights into the fine mechanism of trophoblast invasion., [RefSeq, PubMed]; Plays a role in regulating the phenotype and growth properties of endothelial cells within distinct capillary beds, [RefSeq, PubMed]; Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; This is the first report demonstrating that Prok-1 acts as a gut mucosa/mesenchyme-derived factor and maintains proliferation and differentiation of enteric neural crest cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P609;Q8K457", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0007623 circadian rhythm;GO:0051781 positive regulation of cell division", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q14A28-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TMV7-1", "uniprot_id": [ { "id": "PYRD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TMV7", "type": "external" } ], "mass": 55592.0, "length": 498, "protein_name": "tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1", "gene_name": "Pyroxd1", "organism": "Mouse", "refseq_name": "tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1 isoform a", "refseq_ac": [ { "id": "NP_898988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898988", "type": "external" } ], "gene_names_uniprotkb": "Pyroxd1", "gene_names_refseq": "Pyroxd1", "protein_names_uniprotkb": "tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1; 1.6.99.1; Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1", "protein_names_refseq": "pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1; tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1 isoform a; tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1", "tax_id": 10090, "disease": "myofibrillar myopathy 8 (Disease Ontology:DOID:0080308)", "pathway": " (mmu:232491)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "30345904;31219806;33930333", "class_list": "", "function": "Flavoprotein whose role is to protect RTCB, the catalytic subunit of the tRNA ligase complex (tRNA-LC) involved in tRNA splicing and unfolded protein response, from oxidative inactivation (PubMed:33930333). It directly binds and shields the catalytic center of RTCB, prior to guanylylation, when it is inactive and its active site is vulnerable to oxidation under aerobic conditions. The interaction of PYROXD1 with RTCB is allosterically regulated by NAD(P)H binding and reduction of its FAD cofactor, while reoxidation of PYROXD1 thanks to its NADPH dehydrogenase activity triggers the timed release of RTCB, enabling its subsequent activation. Thereby, this protective mechanism may also function as a molecular timer, regulating RTCB activation through controlled release (By similarity)., [UniProtKB, UniProtKB, PubMed]; Pyroxd1 role in the proliferation, migration, and differentiation of murine myoblasts., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFM2;Q8R2X5", "ec_number_list": [ { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.14.13.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.8", "type": "external" }, { "id": "1.6.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.99.1", "type": "external" }, { "id": "1.14.13.225", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.225", "type": "external" }, { "id": "1.6.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.99.-", "type": "external" } ], "go_molecular_function": "GO:0003954 NADH dehydrogenase activity;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0140299 molecular sensor activity;GO:0003959 NADPH dehydrogenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030017 sarcomere", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0000968 tRNA exon ligation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3TMV7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U4I7-1", "uniprot_id": [ { "id": "PYRD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U4I7", "type": "external" } ], "mass": 62940.0, "length": 581, "protein_name": "Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2", "gene_name": "Pyroxd2", "organism": "Mouse", "refseq_name": "pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2", "refseq_ac": [ { "id": "NP_083287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083287", "type": "external" } ], "gene_names_uniprotkb": "Pyroxd2", "gene_names_refseq": "3830409H07Rik; 4833409A17Rik; Pyroxd2", "protein_names_uniprotkb": "Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; 1.-.-.-", "protein_names_refseq": "pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74580)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Probable oxidoreductase that may play a role as regulator of mitochondrial function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QPD2;Q8CAN2;Q9D630", "ec_number_list": [], "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3U4I7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U5C7-1", "uniprot_id": [ { "id": "PRIC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U5C7", "type": "external" } ], "mass": 94131.0, "length": 832, "protein_name": "Prickle-like protein 1", "gene_name": "Prickle1", "organism": "Mouse", "refseq_name": "prickle-like protein 1", "refseq_ac": [ { "id": "NP_001028389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028389", "type": "external" } ], "gene_names_uniprotkb": "Prickle1", "gene_names_refseq": "1110058P22Rik; Pk1; Prickle1; Prickle; b2b019Clo; mpk1", "protein_names_uniprotkb": "Prickle-like protein 1", "protein_names_refseq": "prickle homolog 1; prickle-like protein 1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive Robinow syndrome (Disease Ontology:DOID:0060764); progressive myoclonus epilepsy 1B (Disease Ontology:DOID:0111448); velocardiofacial syndrome (Disease Ontology:DOID:12583); epilepsy (Disease Ontology:DOID:1826); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (mmu:106042); (R-MMU-4608870)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "18299400;21183079;21952136;25428506;25605945;30084848;30779550;34428180", "class_list": "", "function": "Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure (By similarity). Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0016020 membrane", "go_biological_process": "GO:0085029 extracellular matrix assembly;GO:0061326 renal tubule development;GO:0007409 axonogenesis;GO:0007507 heart development;GO:0016358 dendrite development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3U5C7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4FK66-1", "uniprot_id": [ { "id": "PR38A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4FK66", "type": "external" } ], "mass": 37437.0, "length": 312, "protein_name": "Pre-mRNA-splicing factor 38A", "gene_name": "Prpf38a", "organism": "Mouse", "refseq_name": "pre-mRNA-splicing factor 38A", "refseq_ac": [ { "id": "NP_766285", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766285", "type": "external" } ], "gene_names_uniprotkb": "Prpf38a", "gene_names_refseq": "2410002M20Rik; Prpf38a", "protein_names_uniprotkb": "Pre-mRNA-splicing factor 38A", "protein_names_refseq": "pre-mRNA-splicing factor 38A", "tax_id": 10090, "disease": "", "pathway": " (mmu:230596); (R-MMU-72163)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "17242355;21183079;25428506;30084848;31219806;34428180", "class_list": "", "function": "Involved in pre-mRNA splicing as a component of the spliceosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PB58;Q8BVY2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0071011 precatalytic spliceosome;GO:0071005 U2-type precatalytic spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q4FK66-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64434-1", "uniprot_id": [ { "id": "PTK6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64434", "type": "external" } ], "mass": 51972.0, "length": 451, "protein_name": "Protein-tyrosine kinase 6", "gene_name": "Ptk6", "organism": "Mouse", "refseq_name": "protein-tyrosine kinase 6 isoform 1", "refseq_ac": [ { "id": "NP_033210", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033210", "type": "external" } ], "gene_names_uniprotkb": "Ptk6; Sik", "gene_names_refseq": "BRK; Ptk6; Sik; Tksk; tks", "protein_names_uniprotkb": "Protein-tyrosine kinase 6; 2.7.10.2; SRC-related intestinal kinase", "protein_names_refseq": "protein-tyrosine kinase 6 isoform 1; protein-tyrosine kinase 6; src-related intestinal kinase; tyrosine kinase identified from skin", "tax_id": 10090, "disease": "intestinal cancer (Disease Ontology:DOID:10155); Goldenhar syndrome (Disease Ontology:DOID:2907); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:20459); (R-MMU-187577); (R-MMU-69231); (R-MMU-8847993); (R-MMU-8849468); (R-MMU-8849469); (R-MMU-8849470); (R-MMU-8849471); (R-MMU-8849472); (R-MMU-8849474); (R-MMU-8857538)", "pathway_count": 11, "publication_count": 14, "publication_id_list": "10430081;10913193;12833144;15471878;16782882;19501589;23027128;26247733;27119373;31844057;34428180;36228719;7838533;9405638", "class_list": "", "function": "Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Phosphorylates the GTPase-activating protein ARAP1 following EGF stimulation which enhances EGFR signaling by delaying EGFR down-regulation (By similarity). Also associates with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; PTK6 may act as a novel mediator of TNFalpha/IFNgamma intestinal epithelial permeability during inflammatory injury, and miR-93 may protect intestinal epithelial barrier function, at least in part, by targeting PTK6 Publication Status: Online-Only, [RefSeq, PubMed]; Protein tyrosine kinase 6 regulates activation of SRC kinase., [RefSeq, PubMed]; Ptk6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0010976 positive regulation of neuron projection development;GO:0016477 cell migration;GO:0030154 cell differentiation;GO:0071300 cellular response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q64434-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69Z61-1", "uniprot_id": [ { "id": "PWP2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69Z61", "type": "external" } ], "mass": 79388.0, "length": 730, "protein_name": "PWWP domain-containing protein 2A", "gene_name": "Pwwp2a", "organism": "Mouse", "refseq_name": "PWWP domain-containing protein 2A isoform a", "refseq_ac": [ { "id": "NP_001157703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157703", "type": "external" } ], "gene_names_uniprotkb": "Pwwp2a; Kiaa1935", "gene_names_refseq": "4631424J17Rik; D930040F23Rik; Pwwp2a", "protein_names_uniprotkb": "PWWP domain-containing protein 2A", "protein_names_refseq": "PWWP domain-containing protein 2A isoform a; PWWP domain-containing protein 2A", "tax_id": 10090, "disease": "", "pathway": " (mmu:70802); (R-MMU-9937850)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;25428506;30228260;33235983", "class_list": "", "function": "Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260, PubMed:33235983). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (By similarity). Plays a role in facilitating transcriptional elongation and repression of spurious transcription initiation through regulation of histone acetylation (PubMed:30228260, PubMed:33235983). Essential for proper mitosis progression (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Study in HeLa, HEK293F, and mouse embryonic stem cells reveal that loss of PWWP2A/B leads to increases in histone acetylation predominantly at highly expressed genes, accompanied by decreases in Pol II elongation. Collectively, these findings suggest a role for PWWP2A/B in regulating transcription through the fine-tuning of histone acetylation dynamics at actively transcribed genes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AJK9;A2AJL0;Q3TBG3;Q9CUT9", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding;GO:0120325 NuRD complex binding;GO:0140003 histone H3K36me3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q69Z61-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6M5-1", "uniprot_id": [ { "id": "PX11C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P6M5", "type": "external" } ], "mass": 27152.0, "length": 241, "protein_name": "Peroxisomal membrane protein 11C", "gene_name": "Pex11g", "organism": "Mouse", "refseq_name": "peroxisomal membrane protein 11C isoform 2", "refseq_ac": [ { "id": "NP_081227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081227", "type": "external" } ], "gene_names_uniprotkb": "Pex11g; Pex11c", "gene_names_refseq": "1810022F11Rik; 1810049N02Rik; Pex11c; Pex11gamma; Pex11g", "protein_names_uniprotkb": "Peroxisomal membrane protein 11C; PEX11-gamma; Peroxin-11C; Peroxisomal biogenesis factor 11C; Protein PEX11 homolog gamma", "protein_names_refseq": "PEX11-gamma; peroxin-11C; peroxisomal biogenesis factor 11c; peroxisomal membrane protein 11C isoform 2; peroxisomal membrane protein 11C; protein PEX11 homolog gamma", "tax_id": 10090, "disease": "", "pathway": " (mmu:69129)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12417726", "class_list": "", "function": "Promotes membrane protrusion and elongation on the peroxisomal surface., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8P0;Q9D8X4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0016559 peroxisome fission;GO:0044375 regulation of peroxisome size", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P6M5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6VMN6-1", "uniprot_id": [ { "id": "PRLHR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6VMN6", "type": "external" } ], "mass": 41182.0, "length": 370, "protein_name": "Prolactin-releasing peptide receptor", "gene_name": "Prlhr", "organism": "Mouse", "refseq_name": "prolactin-releasing peptide receptor", "refseq_ac": [ { "id": "NP_963909", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_963909", "type": "external" } ], "gene_names_uniprotkb": "Prlhr; Gm339; Gpr10", "gene_names_refseq": "Gm339; Gpr10; Gr3; Prlhr; Prrpr", "protein_names_uniprotkb": "Prolactin-releasing peptide receptor; G protein-coupled receptor 10; PrRP receptor; PrRPR", "protein_names_refseq": "G-protein coupled receptor 10; PrRP receptor; prolactin-releasing peptide receptor", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); Parkinson's disease (Disease Ontology:DOID:14330); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:226278); (R-MMU-375276)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "14742914;16299503;17904108;33450349", "class_list": "", "function": "Altogether, our data identify the PrRP-GPR10 system as a new and potent negative modulator of the opioid system., [RefSeq, PubMed]; Female mice deficient of the gene encoding GPR10 develop higher body weight and obesity due to lower energy expenditure., [RefSeq, PubMed]; GPR10 gene deletion in mice increases basal neuronal activity, disturbs insulin sensitivity and alters lipid homeostasis., [RefSeq, PubMed]; Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QJU3;Q059H6", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0017046 peptide hormone binding;GO:0008188 neuropeptide receptor activity;GO:0004983 neuropeptide Y receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0043005 neuron projection;GO:0097731 9+0 non-motile cilium", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0007631 feeding behavior;GO:0008343 adult feeding behavior;GO:0042445 hormone metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6VMN6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80VM8-1", "uniprot_id": [ { "id": "PNM8A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80VM8", "type": "external" } ], "mass": 48062.0, "length": 430, "protein_name": "Paraneoplastic antigen-like protein 8A", "gene_name": "Pnma8a", "organism": "Mouse", "refseq_name": "paraneoplastic antigen-like protein 8A", "refseq_ac": [ { "id": "NP_001007570", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007570", "type": "external" } ], "gene_names_uniprotkb": "Pnma8a; Pnmal1", "gene_names_refseq": "0710005I19Rik; 4930488B01Rik; Pnma8a; Pnmal1", "protein_names_uniprotkb": "Paraneoplastic antigen-like protein 8A; PNMA-like protein 1", "protein_names_refseq": "PNMA-like 1; PNMA-like protein 1; paraneoplastic antigen-like protein 8A", "tax_id": 10090, "disease": "", "pathway": " (mmu:71691)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C533", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80VM8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80Y24-1", "uniprot_id": [ { "id": "PRIC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80Y24", "type": "external" } ], "mass": 95781.0, "length": 845, "protein_name": "Prickle-like protein 2", "gene_name": "Prickle2", "organism": "Mouse", "refseq_name": "prickle-like protein 2 isoform b", "refseq_ac": [ { "id": "NP_001127931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001127931", "type": "external" } ], "gene_names_uniprotkb": "Prickle2", "gene_names_refseq": "6230400G14Rik; 6720451F06Rik; Pk2; Prickle2; mpk2", "protein_names_uniprotkb": "Prickle-like protein 2", "protein_names_refseq": "prickle homolog 2; prickle-like protein 2 isoform b; prickle-like protein 2", "tax_id": 10090, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:243548)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12525887;16452087;17376975;21183079;21276947;22333836;22645316;32641624;34428180", "class_list": "", "function": "Is involved in the organization and maintenance of axon initial segment (AIS) cytoskeletal architecture, likely cooperating with IGSF9B to regulate ANK3/ANKG localization to AIS (PubMed:32641624). By binding to and regulating ANK3/ANKG, it modulates its ability to bundle microtubules, a crucial mechanism for establishing neuronal polarity and AIS formation (By similarity). During early embryonic development, has a role in blastocyst formation, likely controlling the redistribution of the microtubule network during embryo compaction and the establishment of apical/basal cell polarity (PubMed:22333836)., [UniProtKB, UniProtKB, PubMed, PubMed]; Putative planar cell polarity protein prickle-like 2 is distributed in crescents on the medial sides of vestibular epithelial cells before the morphological polarization of hair cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A6H652", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0030424 axon", "go_biological_process": "GO:0099612 protein localization to axon;GO:0031175 neuron projection development;GO:0051602 response to electrical stimulus;GO:1990403 embryonic brain development;GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q80Y24-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810Y8-1", "uniprot_id": [ { "id": "PRAL7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q810Y8", "type": "external" } ], "mass": 55834.0, "length": 479, "protein_name": "Preferentially expressed antigen in melanoma-like protein 7", "gene_name": "Pramel7", "organism": "Mouse", "refseq_name": "preferentially expressed antigen in melanoma-like protein 7", "refseq_ac": [ { "id": "NP_839981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_839981", "type": "external" } ], "gene_names_uniprotkb": "Pramel7", "gene_names_refseq": "Pramel7", "protein_names_uniprotkb": "Preferentially expressed antigen in melanoma-like protein 7; Prame-like 7", "protein_names_refseq": "preferentially expressed antigen in melanoma like 7; preferentially expressed antigen in melanoma-like protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:347712)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12620990;21425410;28604677", "class_list": "", "function": "Pramel7 (PRAME-like 7), a protein highly expressed in the inner cell mass but expressed at low levels in embryonic stem cells, targets proteasomal degradation of UHRF1, a key factor for DNA methylation maintenance. Erratum:[Nat Cell Biol. 2017 Jul 28;19(8):1003. doi: 10.1038/ncb3572. PMID: 28752849], [RefSeq, PubMed]; Pramel7 represents a central and essential factor in the signaling network regulating pluripotency and self-renewal in embryonic stem cells., [RefSeq, PubMed]; Promotes maintenance and self-renewal of pluripotent embryonic stem cells (ESCs), downstream of LIF/STAT3 (PubMed:21425410). Maintains the pluripotency state of ESCs by repressing DNA methylation through the regulation of UHRF1 stability. Mediates the proteasomal degradation of UHRF1. Is required for the establishment of the blastocyst (PubMed:28604677)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPY5", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0019827 stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q810Y8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BFW3-1", "uniprot_id": [ { "id": "PR15B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BFW3", "type": "external" } ], "mass": 77712.0, "length": 697, "protein_name": "Protein phosphatase 1 regulatory subunit 15B", "gene_name": "Ppp1r15b", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 15B", "refseq_ac": [ { "id": "NP_598580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598580", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r15b", "gene_names_refseq": "1810033K10Rik; C530022L24Rik; CReP; Ppp1r15b", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 15B; CReP; Constitutive repressor of eIF2alpha phosphorylation", "protein_names_refseq": "constitutive repressor of eIF2alpha phosphorylation; protein phosphatase 1 regulatory subunit 15B; protein phosphatase 1, regulatory (inhibitor) subunit 15b", "tax_id": 10090, "disease": "", "pathway": " (mmu:108954)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14638860;16835242;19181853;27161320;29698569", "class_list": "", "function": "CReP deletion activates a linear signaling pathway involving eIF2alpha phosphorylation, ATF4 translation, and FGF21 induction, which promotes increased energy expenditure, and subsequently improved obesity-related metabolic parameters., [RefSeq, PubMed]; Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1., [UniProtKB, PubMed, PubMed]; Ppp1r15a mutant mice are superficially indistinguishable from wild type; Ppp1r15b(-/-) mouse embryos survive gestation but exhibit severe growth retardation and impaired erythropoiesis, and loss of both Ppp1r15 genes leads to early embryonic lethality, [RefSeq, PubMed]; Results highlighted the essential roles played by GADD34 and CReP in regulating mRNA translation during unstressed conditions and following endoplasmic reticulum stress. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TC78;Q8C390", "ec_number_list": [], "go_molecular_function": "GO:0071074 eukaryotic initiation factor eIF2 binding;GO:0060090 molecular adaptor activity;GO:0019888 protein phosphatase regulator activity;GO:0008157 protein phosphatase 1 binding", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0001933 negative regulation of protein phosphorylation;GO:0042542 response to hydrogen peroxide;GO:0006446 regulation of translational initiation;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BFW3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BII1-1", "uniprot_id": [ { "id": "PROX2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BII1", "type": "external" } ], "mass": 65759.0, "length": 593, "protein_name": "Prospero homeobox protein 2", "gene_name": "Prox2", "organism": "Mouse", "refseq_name": "prospero homeobox protein 2", "refseq_ac": [ { "id": "NP_780407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780407", "type": "external" } ], "gene_names_uniprotkb": "Prox2", "gene_names_refseq": "1700058C01Rik; Prox2", "protein_names_uniprotkb": "Prospero homeobox protein 2; Homeobox prospero-like protein PROX2; PROX-2", "protein_names_refseq": "homeobox prospero-like protein PROX2; prospero homeobox protein 2", "tax_id": 10090, "disease": "brain cancer (Disease Ontology:DOID:1319); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:73422)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16470382;34428180;37192624", "class_list": "", "function": "Compared to mouse Prox1, mouse Prox2 is dispensable for embryonic development, retinal horizontal cell generation, and fertility., [RefSeq, PubMed]; Prox2 and Runx3 vagal sensory neurons regulate esophageal motility., [RefSeq, PubMed]; Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0035295 tube development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BII1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BUM3-1", "uniprot_id": [ { "id": "PTN7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BUM3", "type": "external" } ], "mass": 40351.0, "length": 359, "protein_name": "Tyrosine-protein phosphatase non-receptor type 7", "gene_name": "Ptpn7", "organism": "Mouse", "refseq_name": "tyrosine-protein phosphatase non-receptor type 7", "refseq_ac": [ { "id": "NP_796055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796055", "type": "external" } ], "gene_names_uniprotkb": "Ptpn7", "gene_names_refseq": "BPTP-4; C920001D21Rik; HEPTP; LC-PTP; LPTP; Ptpn7", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 7; 3.1.3.48; HEPTP; Hematopoietic protein-tyrosine phosphatase", "protein_names_refseq": "hematopoietic protein-tyrosine phosphatase; tyrosine-protein phosphatase non-receptor type 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:320139); (R-MMU-5675221)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "19047375;20157115;21183079;24265715;31266805;34428180", "class_list": "", "function": "Beta(2)AR stimulation on a B cell phosphorylates and inactivates HePTP in a Gs/cAMP/PKA-dependent manner to release bound p38 MAPK, making more available for phosphorylation and subsequent IgE regulation., [RefSeq, PubMed]; May play a role in the regulation of T and B-lymphocyte development and signal transduction., [UniProtKB]; PTPN7 as a negative regulator of TNF-alpha expression and the inflammatory response in macrophages Publication Status: Online-Only, [RefSeq, PubMed]; PTPN7 regulates platelet functional responses downstream of GPCR agonists, but not GPVI agonists, through inhibition of ERK activation and thromboxane generation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0009898 cytoplasmic side of plasma membrane;GO:0072686 mitotic spindle", "go_biological_process": "GO:0007165 signal transduction;GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BUM3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BVT6-1", "uniprot_id": [ { "id": "PP2D1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BVT6", "type": "external" } ], "mass": 70630.0, "length": 620, "protein_name": "Protein phosphatase 2C-like domain-containing protein 1", "gene_name": "Pp2d1", "organism": "Mouse", "refseq_name": "protein phosphatase 2C-like domain-containing protein 1", "refseq_ac": [ { "id": "NP_775625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775625", "type": "external" } ], "gene_names_uniprotkb": "Pp2d1", "gene_names_refseq": "4921523A10Rik; Pp2d1", "protein_names_uniprotkb": "Protein phosphatase 2C-like domain-containing protein 1", "protein_names_refseq": "PP2C-like domain-containing protein C3orf48 homolog; protein phosphatase 2C-like domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:110332)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BVT6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CC86-1", "uniprot_id": [ { "id": "PNCB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CC86", "type": "external" } ], "mass": 58265.0, "length": 538, "protein_name": "Nicotinate phosphoribosyltransferase", "gene_name": "Naprt", "organism": "Mouse", "refseq_name": "nicotinate phosphoribosyltransferase", "refseq_ac": [ { "id": "NP_766195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766195", "type": "external" } ], "gene_names_uniprotkb": "Naprt; Naprt1", "gene_names_refseq": "9130210N20Rik; Naprt1; Naprt", "protein_names_uniprotkb": "Nicotinate phosphoribosyltransferase; 6.3.4.21; NAPRTase; Nicotinate phosphoribosyltransferase domain-containing protein 1", "protein_names_refseq": "NAPRTase; nicotinate phosphoribosyltransferase domain containing 1; nicotinate phosphoribosyltransferase domain-containing protein 1; nicotinate phosphoribosyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:223646); (R-MMU-196807); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "17604275;21750661;28416276", "class_list": "", "function": "Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; NA elevates cellular NAD levels through NAPRT function and, thus, protects the cells against stress, partly due to lack of feedback inhibition of NAPRT but not NamPRT by NAD, [RefSeq, PubMed]; Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C7W2", "ec_number_list": [ { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016740 transferase activity;GO:0004516 nicotinate phosphoribosyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0009435 NAD+ biosynthetic process;GO:0034355 NAD+ biosynthetic process via the salvage pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CC86-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZM2-1", "uniprot_id": [ { "id": "PR15L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZM2", "type": "external" } ], "mass": 11359.0, "length": 100, "protein_name": "Proline-rich protein 15-like protein", "gene_name": "Prr15l", "organism": "Mouse", "refseq_name": "proline-rich protein 15-like protein", "refseq_ac": [ { "id": "NP_666138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666138", "type": "external" } ], "gene_names_uniprotkb": "Prr15l; Atad4", "gene_names_refseq": "Atad4; E230006A12Rik; Prr15l", "protein_names_uniprotkb": "Proline-rich protein 15-like protein; Protein ATAD4", "protein_names_refseq": "ATPase family, AAA domain containing 4; proline-rich protein 15-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:217138)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, 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"filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHJ7-1", "uniprot_id": [ { "id": "PRGC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHJ7", "type": "external" } ], "mass": 112075.0, "length": 1014, "protein_name": "Peroxisome proliferator-activated receptor gamma coactivator 1-beta", "gene_name": "Ppargc1b", "organism": "Mouse", "refseq_name": "peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 1", "refseq_ac": [ { "id": "NP_573512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573512", "type": "external" } ], "gene_names_uniprotkb": "Ppargc1b; Errl1; Pgc1b; Pgc1; Ppargc1", "gene_names_refseq": "4631412G21Rik; PGC-1beta/ERRL1; PGC-1beta; PPARGC-1-beta; Perc; Ppargc1b", "protein_names_uniprotkb": "Peroxisome proliferator-activated receptor gamma coactivator 1-beta; ERR ligand 1; PGC-1-beta; PPAR-gamma coactivator 1-beta; PPARGC-1-beta", "protein_names_refseq": "ERR ligand 1; PPAR gamma coactivator-1beta protein; peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 1; peroxisome proliferator-activated receptor gamma coactivator 1-beta", "tax_id": 10090, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:170826)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11733490;12470660;12678921;12734177;14530391;15680331;17618855;18483224;21183079;31219806;34428180;38252822;38815879", "class_list": "", "function": "Dancr-BRG1 regulates Nfatc1 transcription and Pgc1beta-dependent metabolic shifts in osteoclastogenesis. Erratum:[Proc Natl Acad Sci U S A. 2025 Mar 18;122(11):e2502976122. doi: 10.1073/pnas.2502976122. PMID: 40048295], [RefSeq, PubMed]; PGC-1beta/ERRL1 can function as a protein ligand of ERR, and that its level contributes to the control of energy balance in vivo, [RefSeq, PubMed]; Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of the pathways regulating the elevation of gluconeogenesis, beta-oxidation of fatty acids and ketogenesis during fasting. Stimulates SREBP-mediated lipogenic gene expression in the liver. Induces energy expenditure and antagonizes obesity when overexpressed. Also induces the expression of mitochondrial genes involved in oxidative metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Profoundly alter mitochondrial metabolism (PGC-1alpha), [RefSeq, PubMed]; USP7 promotes cardiometabolic disorders and mitochondrial homeostasis dysfunction in diabetic mice via stabilizing PGC1beta., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1C0", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0030331 nuclear estrogen receptor binding;GO:0050682 AF-2 domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016592 mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0097009 energy homeostasis;GO:0030520 estrogen receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8VHJ7-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ58-1", "uniprot_id": [ { "id": "PR8A9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ58", "type": "external" } ], "mass": 27697.0, "length": 241, "protein_name": "Prolactin-8A9", "gene_name": "Prl8a9", "organism": "Mouse", "refseq_name": "prolactin-8A9 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001303650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303650", "type": "external" } ], "gene_names_uniprotkb": "Prl8a9; Prlpc2", "gene_names_refseq": "1600019F10Rik; Ghd15; PLP-C2; PLP-Cbeta; Prl8a9; Prlpc2", "protein_names_uniprotkb": "Prolactin-8A9; PLP C-beta; PLP-C2; PRL-like protein C2; Placental prolactin-like protein C2; Prolactin-like protein C-beta", "protein_names_refseq": "PLP C-beta; PRL-like protein C2; growth hormone d15; placental prolactin-like protein C2; prolactin-8A9 isoform 2 precursor; prolactin-8A9; prolactin-like protein C 2; prolactin-like protein C-beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:67310)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10965907", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQ58-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CX56-1", "uniprot_id": [ { "id": "PSMD8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CX56", "type": "external" } ], "mass": 39930.0, "length": 353, "protein_name": "26S proteasome non-ATPase regulatory subunit 8", "gene_name": "Psmd8", "organism": "Mouse", "refseq_name": "26S proteasome non-ATPase regulatory subunit 8", "refseq_ac": [ { "id": "NP_080821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080821", "type": "external" } ], "gene_names_uniprotkb": "Psmd8", "gene_names_refseq": "6720456J22Rik; Psmd8", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 8; 26S proteasome regulatory subunit RPN12; 26S proteasome regulatory subunit S14", "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 8; 26S proteasome regulatory subunit RPN12; 26S proteasome regulatory subunit S14; proteasome 26S non-ATPase subunit 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:57296); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 56, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;16857966;28315936;31112734;31219806;34428180;37828378", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0022624 proteasome accessory complex;GO:0005634 nucleus;GO:0008021 synaptic vesicle;GO:0000502 proteasome complex;GO:0008541 proteasome regulatory particle, lid subcomplex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CX56-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1C3-1", "uniprot_id": [ { "id": "PREY_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1C3", "type": "external" } ], "mass": 12506.0, "length": 112, "protein_name": "Protein preY, mitochondrial", "gene_name": "Pyurf", "organism": "Mouse", "refseq_name": "protein preY, mitochondrial precursor", "refseq_ac": [ { "id": "NP_079850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079850", "type": "external" } ], "gene_names_uniprotkb": "Pyurf; Pigy; Prey", "gene_names_refseq": "2610022G08Rik; Prey; Pyurf", "protein_names_uniprotkb": "Protein preY, mitochondrial", "protein_names_refseq": "pre-Y homolog; protein preY, mitochondrial precursor; protein preY, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:66459); (R-MMU-6799198)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene", "function": "In mitochondria, S-adenosylmethionine-dependent methyltransferase chaperone that supports both coenzyme Q biosynthesis, by stabilizing its components, such as COQ5, and NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) assembly, by stabilizing complex I assembly factors, such as NDUFAF5., [UniProtKB, UniProtKB]; This gene encodes a small protein with a conserved DUF343 domain. The human ortholog of this gene expresses two distinct proteins from upstream and downstream coding regions. The upstream CDS encoding a DUF343 domain-containing protein has been conserved at this mouse locus, but the downstream CDS encoding a subunit of an enzyme involved in glycosylphosphatidylinositol biosynthesis has not been conserved. Instead, a separate locus on mouse chromosome 9 encodes the mouse homolog of the human phosphatidylinositol glycan anchor biosynthesis, class Y protein. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0050821 protein stabilization;GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D1C3-1", "record_type": "protein", "filter_code": "0000000.1000001.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D600-1", "uniprot_id": [ { "id": "PSF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D600", "type": "external" } ], "mass": 21236.0, "length": 185, "protein_name": "DNA replication complex GINS protein PSF2", "gene_name": "Gins2", "organism": "Mouse", "refseq_name": "DNA replication complex GINS protein PSF2", "refseq_ac": [ { "id": "NP_849187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849187", "type": "external" } ], "gene_names_uniprotkb": "Gins2; Psf2", "gene_names_refseq": "2210013I18Rik; 4833427B12Rik; Gins2; Pfs2; Psf2", "protein_names_uniprotkb": "DNA replication complex GINS protein PSF2; GINS complex subunit 2", "protein_names_refseq": "DNA replication complex GINS protein PSF2; GINS complex subunit 2 (Psf2 homolog)", "tax_id": 10090, "disease": "", "pathway": " (mmu:272551); (R-MMU-176974)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "30513217", "class_list": "", "function": "GINS2 plays a protective role in alcohol-induced brain injury, [RefSeq, PubMed]; Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMT2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000811 GINS complex;GO:0071162 CMG complex", "go_biological_process": "GO:0006260 DNA replication;GO:0000727 double-strand break repair via break-induced replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D600-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7G0-1", "uniprot_id": [ { "id": "PRPS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7G0", "type": "external" } ], "mass": 34834.0, "length": 318, "protein_name": "Ribose-phosphate pyrophosphokinase 1", "gene_name": "Prps1", "organism": "Mouse", "refseq_name": "ribose-phosphate pyrophosphokinase 1", "refseq_ac": [ { "id": "NP_067438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067438", "type": "external" } ], "gene_names_uniprotkb": "Prps1", "gene_names_refseq": "2310010D17Rik; PRS-I; Prps-1; Prps1", "protein_names_uniprotkb": "Ribose-phosphate pyrophosphokinase 1; 2.7.6.1; PRS-I; Phosphoribosyl pyrophosphate synthase I", "protein_names_refseq": "phosphoribosyl pyrophosphate synthase I; phosphoribosyl pyrophosphate synthetase I; ribose-phosphate pyrophosphokinase 1", "tax_id": 10090, "disease": "Arts syndrome (Disease Ontology:DOID:0050647); Charcot-Marie-Tooth disease X-linked recessive 5 (Disease Ontology:DOID:0110210); phosphoribosylpyrophosphate synthetase superactivity (Disease Ontology:DOID:0111260); X-linked deafness 1 (Disease Ontology:DOID:0111739); retinitis pigmentosa (Disease Ontology:DOID:10584); gout (Disease Ontology:DOID:13189)", "pathway": " (mmu:19139); (R-MMU-73843)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;19224205;20021999;20173027;25428506;25428507;25605945;30084848;30779550;30899004;31219806;33300544;35820727;37453647", "class_list": "", "function": "Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q76MX9", "ec_number_list": [ { "id": "2.7.6.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.6.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0016208 AMP binding", "go_cellular_component": "GO:0002189 ribose phosphate diphosphokinase complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007399 nervous system development;GO:0006098 pentose-phosphate shunt;GO:0009156 ribonucleoside monophosphate biosynthetic process;GO:0006144 purine nucleobase metabolic process;GO:0034418 urate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9D7G0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9B7-1", "uniprot_id": [ { "id": "PRR30_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9B7", "type": "external" } ], "mass": 43406.0, "length": 401, "protein_name": "Proline-rich protein 30", "gene_name": "Prr30", "organism": "Mouse", "refseq_name": "proline-rich protein 30", "refseq_ac": [ { "id": "NP_083956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083956", "type": "external" } ], "gene_names_uniprotkb": "Prr30", "gene_names_refseq": "1700110M21Rik; Prr30", "protein_names_uniprotkb": "Proline-rich protein 30", "protein_names_refseq": "proline-rich protein 30", "tax_id": 10090, "disease": "", "pathway": " (mmu:76627)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QQ59", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D9B7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAY2-1", "uniprot_id": [ { "id": "PR8A6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAY2", "type": "external" } ], "mass": 27274.0, "length": 240, "protein_name": "Prolactin-8A6", "gene_name": "Prl8a6", "organism": "Mouse", "refseq_name": "prolactin-8A6 isoform a precursor", "refseq_ac": [ { "id": "NP_001258307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258307", "type": "external" } ], "gene_names_uniprotkb": "Prl8a6; Prlpc1; Prlpc", "gene_names_refseq": "Ghd13; PLP-C1; PLP-Ca; PLP-calpha; Prl8a6; Prlpc1; Prlpc", "protein_names_uniprotkb": "Prolactin-8A6; PLP C-alpha; PLP-C1; PRL-like protein C1; Placental prolactin-like protein C1; Prolactin-like protein C-alpha; Prolactin-like protein C", "protein_names_refseq": "PRL-like protein C1; growth hormone d13; placental prolactin-like protein C1; prolactin-8A6 isoform a precursor; prolactin-8A6; prolactin-like protein C 1; prolactin-like protein C-alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:19112)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9832456", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9DAW0;Q9Z249", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005102 signaling receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DAY2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBS8-1", "uniprot_id": [ { "id": "POC5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBS8", "type": "external" } ], "mass": 60956.0, "length": 558, "protein_name": "Centrosomal protein POC5", "gene_name": "Poc5", "organism": "Mouse", "refseq_name": "centrosomal protein POC5", "refseq_ac": [ { "id": "NP_080449", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080449", "type": "external" } ], "gene_names_uniprotkb": "Poc5", "gene_names_refseq": "1200014M14Rik; Poc5", "protein_names_uniprotkb": "Centrosomal protein POC5; Protein of centriole 5", "protein_names_refseq": "POC5 centriolar protein homolog; centrosomal protein POC5; protein of centriole 5", "tax_id": 10090, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:67463)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "20173027;25428506;27802388;30084848;30779550;34203471;34428180", "class_list": "", "function": "Essential for the assembly of the distal half of centrioles, required for centriole elongation. Acts as a negative regulator of centriole elongation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C299;Q8CI36;Q9CZ74", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005814 centriole;GO:0032391 photoreceptor connecting cilium", "go_biological_process": "GO:1903723 negative regulation of centriole elongation;GO:0042462 eye photoreceptor cell development;GO:0061511 centriole elongation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DBS8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCH2-1", "uniprot_id": [ { "id": "POP7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCH2", "type": "external" } ], "mass": 15777.0, "length": 140, "protein_name": "Ribonuclease P protein subunit p20", "gene_name": "Pop7", "organism": "Mouse", "refseq_name": "ribonuclease P protein subunit p20", "refseq_ac": [ { "id": "NP_083029", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083029", "type": "external" } ], "gene_names_uniprotkb": "Pop7; Rpp20", "gene_names_refseq": "0610037N12Rik; Pop7; Rpp20", "protein_names_uniprotkb": "Ribonuclease P protein subunit p20; RNaseP protein p20", "protein_names_refseq": "Pop7 homolog; RNaseP protein p20; ribonuclease P protein subunit p20", "tax_id": 10090, "disease": "", "pathway": " (mmu:74097)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11239002;31219806", "class_list": "", "function": "Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004526 ribonuclease P activity;GO:0033204 ribonuclease P RNA binding", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0030681 multimeric ribonuclease P complex;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0008033 tRNA processing;GO:0006364 rRNA processing;GO:0001682 tRNA 5'-leader removal", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DCH2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPX2-1", "uniprot_id": [ { "id": "PPN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EPX2", "type": "external" } ], "mass": 138904.0, "length": 1280, "protein_name": "Papilin", "gene_name": "Papln", "organism": "Mouse", "refseq_name": "papilin isoform 2 precursor", "refseq_ac": [ { "id": "NP_570957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570957", "type": "external" } ], "gene_names_uniprotkb": "Papln", "gene_names_refseq": "E030033C16Rik; Papln", "protein_names_uniprotkb": "Papilin", "protein_names_refseq": "papilin isoform 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:170721)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;11076767", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2RTE8;B2RQC4;Q99JQ8", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9EPX2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JII2-1", "uniprot_id": [ { "id": "PR5A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JII2", "type": "external" } ], "mass": 26556.0, "length": 230, "protein_name": "Prolactin-5A1", "gene_name": "Prl5a1", "organism": "Mouse", "refseq_name": "prolactin-5A1 precursor", "refseq_ac": [ { "id": "NP_076235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076235", "type": "external" } ], "gene_names_uniprotkb": "Prl5a1; D13Wsu14e; Prlpl", "gene_names_refseq": "1600013P04Rik; D13Wsu14e; Ghd24; PLP-L; Prl5a1; Prlpl", "protein_names_uniprotkb": "Prolactin-5A1; PLP-L; PRL-like protein L; Placental prolactin-like protein L", "protein_names_refseq": "PRL-like protein L; growth hormone d24; placental prolactin-like protein L; prolactin-5A1 precursor; prolactin-5A1", "tax_id": 10090, "disease": "", "pathway": " (mmu:28078)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10906059;12885563", "class_list": "", "function": "Both interstitial and endovascular rat trophoblast cells synthesize PLP-L., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q80X20", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JII2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXU7-1", "uniprot_id": [ { "id": "PROK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXU7", "type": "external" } ], "mass": 14185.0, "length": 128, "protein_name": "Prokineticin-2", "gene_name": "Prok2", "organism": "Mouse", "refseq_name": "prokineticin-2 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001032628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032628", "type": "external" } ], "gene_names_uniprotkb": "Prok2; Bv8", "gene_names_refseq": "Bv8; PK2; Prok1; Prok2", "protein_names_uniprotkb": "Prokineticin-2; PK2; Protein Bv8 homolog", "protein_names_refseq": "Bombina variegata 8 kD protein; Bombina variegata 8kDa protein; Bv 8 homolog (Bombina variegata); prokineticin 1; prokineticin-2 isoform 2 precursor; protein Bv8 homolog", "tax_id": 10090, "disease": "hypogonadotropic hypogonadism 4 with or without anosmia (Disease Ontology:DOID:0090077)", "pathway": " (mmu:50501); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10580115;11054548;12024206;12604792;21750661;38057865", "class_list": "", "function": "Bv8 and EG-VEGF, along with other factors such as VEGF-A, may maintain the integrity and also regulate proliferation of the blood vessels in the testis, [RefSeq, PubMed]; May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle (By similarity)., [UniProtKB, PubMed]; Prokineticin 2 is a catabolic regulator of osteoarthritic cartilage destruction in mouse. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZMX7;Q9QXU5;Q9QXU6", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0001525 angiogenesis;GO:0006935 chemotaxis;GO:0007218 neuropeptide signaling pathway;GO:0007283 spermatogenesis;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9QXU7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1P3-1", "uniprot_id": [ { "id": "PSB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1P3", "type": "external" } ], "mass": 22906.0, "length": 201, "protein_name": "Proteasome subunit beta type-2", "gene_name": "Psmb2", "organism": "Mouse", "refseq_name": "proteasome subunit beta type-2 isoform 1", "refseq_ac": [ { "id": "NP_036100", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036100", "type": "external" } ], "gene_names_uniprotkb": "Psmb2", "gene_names_refseq": "C7-I; D4Wsu33e; HC7-I; Psmb2", "protein_names_uniprotkb": "Proteasome subunit beta type-2; Macropain subunit C7-I; Multicatalytic endopeptidase complex subunit C7-I; Proteasome component C7-I; Proteasome subunit beta-4; beta-4", "protein_names_refseq": "beta-4; macropain subunit C7-I; multicatalytic endopeptidase complex subunit C7-I; proteasome component C7-I; proteasome subunit beta type-2 isoform 1; proteasome subunit beta type-2; proteasome subunit beta-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:26445); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9912633); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 57, "publication_count": 15, "publication_id_list": "10436176;16581775;16857966;22341445;22872234;25428506;26495903;26740625;28011936;30084848;32069316;34428180;35984892;37507081;37828378", "class_list": "", "function": "Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9R1P3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTX2-1", "uniprot_id": [ { "id": "PRKRA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTX2", "type": "external" } ], "mass": 34371.0, "length": 313, "protein_name": "Interferon-inducible double-stranded RNA-dependent protein kinase activator A", "gene_name": "Prkra", "organism": "Mouse", "refseq_name": "interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform 1", "refseq_ac": [ { "id": "NP_036001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036001", "type": "external" } ], "gene_names_uniprotkb": "Prkra; Rax", "gene_names_refseq": "PRK; Pact; Prkra; RAX; lear", "protein_names_uniprotkb": "Interferon-inducible double-stranded RNA-dependent protein kinase activator A; PKR-associated protein X; PKR-associating protein X; Protein activator of the interferon-induced protein kinase; Protein kinase, interferon-inducible double-stranded RNA-dependent activator; RAX", "protein_names_refseq": "PKR-associated protein X; PKR-associating protein X; interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform 1; interferon-inducible double-stranded RNA-dependent protein kinase activator A; protein activator of the interferon-induced protein kinase", "tax_id": 10090, "disease": "dystonia 16 (Disease Ontology:DOID:0090048)", "pathway": " (mmu:23992); (R-MMU-203927); (R-MMU-426486); (R-MMU-9833482)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10336432;15299031;16571658;18299400;20173027;22214662;25428506;28528544;30084848;30779550;33479180;34203471;34428180;35820727;35968982;37185168;37982645", "class_list": "", "function": "Cell-type-specific need of Ddx3 and PACT for interferon induction by RNA viruses., [RefSeq, PubMed]; Prkra Mutation Alters Long Noncoding RNA Expression During Embryonic External Ear Development., [RefSeq, PubMed]; Prkra Mutation Alters mRNA Expression During Embryonic External Ear Development., [RefSeq, PubMed]; RAX phosphorylation at serine 18 is required for PKR activation and consequent translation inhibition, [RefSeq, PubMed]; Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1 (By similarity). Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner. May function as regulator of gastric epithelial differentiation (PubMed:33479180)., [UniProtKB, PubMed, PubMed, PubMed]; Study demonstrated an essential role of PACT in mammalian ear development and produced the first animal model., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZB7", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0070922 RISC complex assembly;GO:0006468 protein phosphorylation;GO:0008284 positive regulation of cell population proliferation;GO:0050821 protein stabilization;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9WTX2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15261-1", "uniprot_id": [ { "id": "INGR1_MOUSE", "url": "https://www.uniprot.org/uniprot/P15261", "type": "external" } ], "mass": 52343.0, "length": 477, "protein_name": "Interferon gamma receptor 1", "gene_name": "Ifngr1", "organism": "Mouse", "refseq_name": "interferon gamma receptor 1 precursor", "refseq_ac": [ { "id": "NP_034641", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034641", "type": "external" } ], "gene_names_uniprotkb": "Ifngr1; Ifngr", "gene_names_refseq": "CD119; IFN-gammaR; Ifgr; Ifngr1; Ifngr; Nktar", "protein_names_uniprotkb": "Interferon gamma receptor 1; IFN-gamma receptor 1; IFN-gamma-R-alpha; IFN-gamma-R1; Interferon gamma receptor alpha-chain", "protein_names_refseq": "IFN-gamma receptor 1; IFN-gamma-R-alpha; IFN-gamma-R1; INF-g receptor; interferon gamma receptor 1 precursor; interferon gamma receptor alpha-chain", "tax_id": 10090, "disease": "immunodeficiency 27A (Disease Ontology:DOID:0111955); immunodeficiency 27B (Disease Ontology:DOID:0111956); osteoporosis (Disease Ontology:DOID:11476); allergic disease (Disease Ontology:DOID:1205); uveitis (Disease Ontology:DOID:13141); hepatitis B (Disease Ontology:DOID:2043); arteriosclerosis (Disease Ontology:DOID:2349); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); tuberculosis (Disease Ontology:DOID:399); pulmonary hypertension (Disease Ontology:DOID:6432); periodontitis (Disease Ontology:DOID:824)", "pathway": " (mmu:15979); (R-MMU-877300); (R-MMU-877312); (R-MMU-9732724)", "pathway_count": 4, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;15284232;15522878;17242355;19889125;20926559;21183079;2137461;21750661;2530216;2530582;2531896;2532365;26495903;26740625;27286456;28011936;31599954;32069316;35984892;37828378;7890167", "class_list": "", "function": "Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (, PubMed:20926559, PubMed:27286456). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:2137461, PubMed:2530216, PubMed:2530582, PubMed:2531896, PubMed:2532365). Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to its dimerization, translocation to the nucleus, and stimulation of target gene transcription (PubMed:19889125). STAT3 can also be activated in a similar manner although activation seems weaker (PubMed:15284232). IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (PubMed:15522878)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q91Y85", "ec_number_list": [], "go_molecular_function": "GO:0004906 type II interferon receptor activity;GO:0019955 cytokine binding;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0031982 vesicle", "go_biological_process": "GO:0001774 microglial cell activation;GO:0010628 positive regulation of gene expression;GO:0048143 astrocyte activation;GO:0051607 defense response to virus;GO:1902004 positive regulation of amyloid-beta formation", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P15261-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06831-1", "uniprot_id": [ { "id": "SOX4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q06831", "type": "external" } ], "mass": 45044.0, "length": 440, "protein_name": "Transcription factor SOX-4", "gene_name": "Sox4", "organism": "Mouse", "refseq_name": "transcription factor SOX-4", "refseq_ac": [ { "id": "NP_033264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033264", "type": "external" } ], "gene_names_uniprotkb": "Sox4; Sox-4", "gene_names_refseq": "Sox-4; Sox4", "protein_names_uniprotkb": "Transcription factor SOX-4", "protein_names_refseq": "SRY-box containing gene 4; transcription factor SOX-4", "tax_id": 10090, "disease": "Coffin-Siris syndrome 10 (Disease Ontology:DOID:0112371); urinary bladder cancer (Disease Ontology:DOID:11054); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:20677); (R-MMU-3769402)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "15345747;17218525;23562159;26291311;30084848;34428180;8404853;8493110;8921394", "class_list": "", "function": "Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif (PubMed:8404853). Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression (PubMed:23562159). Involved in skeletal myoblast differentiation by promoting gene expression of CALD1 (PubMed:26291311)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5SW95", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0002328 pro-B cell differentiation;GO:0060993 kidney morphogenesis;GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator;GO:0021782 glial cell development;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q06831-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35988-1", "uniprot_id": [ { "id": "SDC4_MOUSE", "url": "https://www.uniprot.org/uniprot/O35988", "type": "external" } ], "mass": 21482.0, "length": 198, "protein_name": "Syndecan-4", "gene_name": "Sdc4", "organism": "Mouse", "refseq_name": "syndecan-4 precursor", "refseq_ac": [ { "id": "NP_035651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035651", "type": "external" } ], "gene_names_uniprotkb": "Sdc4", "gene_names_refseq": "S4; Sdc4; Synd4; ryudocan; syndecan-4", "protein_names_uniprotkb": "Syndecan-4; Ryudocan core protein; SYND4", "protein_names_refseq": "ryudocan core protein; syndecan-4 precursor", "tax_id": 10090, "disease": "bacterial infectious disease (Disease Ontology:DOID:104); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:20971); (R-MMU-1971475); (R-MMU-2022928); (R-MMU-2024096); (R-MMU-3000170); (R-MMU-975634); (R-MMU-9769735); (R-MMU-9769739)", "pathway_count": 8, "publication_count": 20, "publication_id_list": "10684261;10911369;11805099;15694365;19224205;20173027;22164265;25428506;26495903;30084848;30779550;31219806;31907416;33300544;34428180;35820727;37108098;37828378;38806135;9276666", "class_list": "glycogene", "function": "Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP., [UniProtKB, UniProtKB]; Sdc4 deletion perturbs intervertebral disc matrix homeostasis and promotes early osteopenia in the aging mouse spine., [RefSeq, PubMed]; Unravelling the Effects of Syndecan-4 Knockdown on Skeletal Muscle Functions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005080 protein kinase C binding;GO:0001968 fibronectin binding;GO:0070053 thrombospondin receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005796 Golgi lumen;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0010762 regulation of fibroblast migration;GO:0016477 cell migration;GO:0042130 negative regulation of T cell proliferation;GO:0045860 positive regulation of protein kinase activity;GO:0051496 positive regulation of stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "O35988-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43407-1", "uniprot_id": [ { "id": "SDC2_MOUSE", "url": "https://www.uniprot.org/uniprot/P43407", "type": "external" } ], "mass": 22131.0, "length": 202, "protein_name": "Syndecan-2", "gene_name": "Sdc2", "organism": "Mouse", "refseq_name": "syndecan-2 precursor", "refseq_ac": [ { "id": "NP_032330", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032330", "type": "external" } ], "gene_names_uniprotkb": "Sdc2; Hspg1; Synd2", "gene_names_refseq": "4833414L08Rik; Hspg1; Sdc2; Synd2; syndecan-2", "protein_names_uniprotkb": "Syndecan-2; Fibroglycan; HSPG; Heparan sulfate proteoglycan core protein; SYND2", "protein_names_refseq": "HSPG; heparan sulfate proteoglycan 1, cell surface-associated (fibroglycan); heparan sulfate proteoglycan core protein; syndecan-2 precursor", "tax_id": 10090, "disease": "cleft palate (Disease Ontology:DOID:674); cleft lip (Disease Ontology:DOID:9296); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:15529); (R-MMU-1971475); (R-MMU-2022928); (R-MMU-2024096); (R-MMU-3000170); (R-MMU-381426); (R-MMU-3928662); (R-MMU-8957275); (R-MMU-975634); (R-MMU-9769735); (R-MMU-9769739)", "pathway_count": 11, "publication_count": 6, "publication_id_list": "21555464;35139425;35181688;35820727;8187643;8645178", "class_list": "glycogene", "function": "Cell surface proteoglycan which regulates dendritic arbor morphogenesis., [UniProtKB, PubMed]; Shed syndecan-2 enhances colon cancer progression by increasing cooperative angiogenesis in the tumor microenvironment., [RefSeq, PubMed]; Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 10, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005796 Golgi lumen;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043025 neuronal cell body", "go_biological_process": "GO:0016477 cell migration;GO:0045785 positive regulation of cell adhesion;GO:0048814 regulation of dendrite morphogenesis;GO:0051963 regulation of synapse assembly;GO:0048813 dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P43407-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQQ0-1", "uniprot_id": [ { "id": "OR4E2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQQ0", "type": "external" } ], "mass": 34986.0, "length": 308, "protein_name": "Olfactory receptor 4E2", "gene_name": "Or4e2", "organism": "Mouse", "refseq_name": "olfactory receptor 4E2", "refseq_ac": [ { "id": "NP_065260", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065260", "type": "external" } ], "gene_names_uniprotkb": "Or4e2; MOR244-3; MOR83; Olfr1509", "gene_names_refseq": "MOR244-3; Mor83; Olfr1509; Or4e2; Or83", "protein_names_uniprotkb": "Olfactory receptor 4E2; Odorant receptor 244-3; Odorant receptor 83; Olfactory receptor 1509", "protein_names_refseq": "GA_x6K02T2RJGY-534312-533386; gene for odorant receptor MOR83; odorant receptor 244-3; odorant receptor 83; olfactory receptor 1509; olfactory receptor 4E2; olfactory receptor MOR244-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:57271)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10493742;18214836;21750661;22328155;25185561;25901328;27019154;29659735", "class_list": "", "function": "Olfactory receptor that is activated by the binding of organosulfur odorants with thioether groups such as (methylthio)methanethiol (MTMT) and bis(methylthiomethyl) disulfide (PubMed:22328155, PubMed:25185561, PubMed:25901328, PubMed:29659735). Also binds odorants cis-cyclooctene and tert-butyl mercaptan (PubMed:27019154). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (Potential)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 51, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0U1RP41;Q9R0K3", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005507 copper ion binding;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0050907 detection of chemical stimulus involved in sensory perception;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7TQQ0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "K7N6P1-1", "uniprot_id": [ { "id": "K7N6P1_MOUSE", "url": "https://www.uniprot.org/uniprot/K7N6P1", "type": "external" } ], "mass": 21166.0, "length": 191, "protein_name": "Reproductive homeobox 2H", "gene_name": "Rhox2h", "organism": "Mouse", "refseq_name": "reproductive homeobox 2H", "refseq_ac": [ { "id": "NP_001093935", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093935", "type": "external" } ], "gene_names_uniprotkb": "Rhox2h", "gene_names_refseq": "Rhox2.8; Rhox2g; Rhox2h", "protein_names_uniprotkb": "Reproductive homeobox 2H", "protein_names_refseq": "reproductive homeobox 2G; reproductive homeobox 2H", "tax_id": 10090, "disease": "", "pathway": " (mmu:622301)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "K7N6P1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UL53-1", "uniprot_id": [ { "id": "CRXOS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UL53", "type": "external" } ], "mass": 29090.0, "length": 246, "protein_name": "Homeobox protein Crxos", "gene_name": "Crxos", "organism": "Mouse", "refseq_name": "homeobox protein Crxos isoform a", "refseq_ac": [ { "id": "NP_001028810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028810", "type": "external" } ], "gene_names_uniprotkb": "Crxos", "gene_names_refseq": "Crxos1; Crxos; Egam1", "protein_names_uniprotkb": "Homeobox protein Crxos; Cone-rod homeobox, opposite strand protein; EGAM1; Expressing gene at morula stage protein 1", "protein_names_refseq": "Crx opposite strand transcript 1; cone-rod homeobox, opposite strand protein; expressing gene at morula stage protein 1; homeobox protein Crxos isoform a; homeobox protein Crxos", "tax_id": 10090, "disease": "", "pathway": " (mmu:546024)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19800316;20018908;21084569;22367590;22608553;22785471;23510645;25817697;26983934;29423137", "class_list": "", "function": "EGAM1C may play a role in the expression of members of the placental PRL gene family, such as Prl3b1 and Prl5a1., [RefSeq, PubMed]; Expression of EGAM1N could inhibit differentiation by elevating the protein levels of pluripotency factors in mouse ES cells., [RefSeq, PubMed]; Nuclear localization of exogenously expressed EGAM1 homeoproteins (EGAM1, EGAM1N, and EGAM1C) was determined. The amino acid residues crucial for the nuclear translocation of EGAM1 and EGAM1C were identified., [RefSeq, PubMed]; The generation of cardiomyocytes was severely suppressed in Egam1c transfectants without upregulation of Nkx2-5, a crucial gene for cardiomyogenesis. These results indicate that EGAM1C is capable of affecting terminal differentiation in mouse ES cells., [RefSeq, PubMed]; These transcripts encoding homeoproteins are capable of regulating the maintenance and/or differentiation of mouse ES cells and likely regulate that of preimplantation embryos., [RefSeq, PubMed]; This is the first delineation of the physiological role of CrxOS in ES cells., [RefSeq, PubMed]; Transcription factor that acts as a positive regulator of embryonic stem cell differentiation., [UniProtKB, PubMed]; Transcription factor that acts as a regulator of embryonic stem cell differentiation during the preimplantation stages of embryonic development., [UniProtKB, PubMed, PubMed, PubMed]; Transcription factor that promotes embryonic stem cell pluripotency (PubMed:22367590, PubMed:22785471). Also involved in extraembryonic tissues development by promoting the expression of placental prolactin family genes (PubMed:21084569)., [UniProtKB, PubMed, PubMed, PubMed]; Transcription factor that promotes embryonic stem cell pluripotency., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B6ZND8;B6ZND9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0019827 stem cell population maintenance;GO:0001892 embryonic placenta development;GO:0001835 blastocyst hatching", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3UL53-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920Z2-1", "uniprot_id": [ { "id": "Q920Z2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q920Z2", "type": "external" } ], "mass": 35150.0, "length": 318, "protein_name": "Olfactory receptor", "gene_name": "Or13n4", "organism": "Mouse", "refseq_name": "olfactory receptor 702", "refseq_ac": [ { "id": "NP_666808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666808", "type": "external" } ], "gene_names_uniprotkb": "Or13n4; Olfr702", "gene_names_refseq": "MOR260-4; Olfr702; Or13n4", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "B7 olfactory receptor; GA_x6K02T2PBJ9-9202245-9201289; olfactory receptor 702; olfactory receptor MOR260-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:258590)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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(R-MMU-9639288); (R-MMU-983712)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "14585495;16174750;21750661;23028982;29993276;34428180", "class_list": "", "function": "Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:16174750, PubMed:23028982). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Essential for the proper assembly and activity of V-ATPase (By similarity). In renal intercalated cells, mediates secretion of protons (H+) into the urine thereby ensuring correct urinary acidification (PubMed:16174750). Required for optimal olfactory function by mediating the acidification of the nasal olfactory epithelium (PubMed:23028982)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6I3;Q8C3L6", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0044877 protein-containing complex binding;GO:0015078 proton transmembrane transporter activity;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0042048 olfactory behavior;GO:0003096 renal sodium ion transport;GO:0003091 renal water homeostasis;GO:0030534 adult behavior;GO:0042472 inner ear morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q91YH6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0U1RQ45-1", "uniprot_id": [ { "id": "TM275_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A0U1RQ45", "type": "external" } ], "mass": 17701.0, "length": 177, "protein_name": "Transmembrane protein 275", "gene_name": "Tmem275", "organism": "Mouse", "refseq_name": "transmembrane protein 275", "refseq_ac": [ { "id": "NP_001343989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001343989", "type": "external" } ], "gene_names_uniprotkb": "Tmem275", "gene_names_refseq": "6430628N08Rik; Tmem275", "protein_names_uniprotkb": "Transmembrane protein 275", "protein_names_refseq": "transmembrane protein 275", "tax_id": 10090, "disease": "", "pathway": " (mmu:76237)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0U1RQ45-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PHP4-1", "uniprot_id": [ { "id": "Z512B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PHP4", "type": "external" } ], "mass": 98369.0, "length": 900, "protein_name": "Zinc finger protein 512B", "gene_name": "Zfp512b; Znf512b", "organism": "Mouse", "refseq_name": "zinc finger protein 512B isoform 4", "refseq_ac": [ { "id": "NP_001158069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158069", "type": "external" } ], "gene_names_uniprotkb": "Zfp512b; Znf512b; Gm632; Zfp512b", "gene_names_refseq": "Gm632; Zfp512b; Znf512b", "protein_names_uniprotkb": "Zinc finger protein 512B", "protein_names_refseq": "zinc finger protein 512B isoform 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:269401); (R-MMU-9013424)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;38961301", "class_list": "", "function": "Involved in transcriptional regulation by repressing gene expression. Associates with the nucleosome remodeling and histone deacetylase (NuRD) complex, which promotes transcriptional repression by histone deacetylation and nucleosome remodeling. Sequence-specific DNA-binding protein that recognizes repetitive and non-consecutive TTC sequences in pericentric repeat and initiate heterochromatin formation through interaction with SUV39H1/2 methyltransferases which catalyze histone H3K9 methylation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; Sequence-specific DNA-binding protein that recognizes repetitive and non-consecutive TTC sequences in pericentric repeat and initiates heterochromatin formation through interaction with SUV39H1/2 methyltransferases which catalyze histone H3K9 methylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPW1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005721 pericentric heterochromatin;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:1902894 negative regulation of miRNA transcription;GO:0140719 constitutive heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PHP4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3QMS2-1", "uniprot_id": [ { "id": "J3QMS2_MOUSE", "url": "https://www.uniprot.org/uniprot/J3QMS2", "type": "external" } ], "mass": 108640.0, "length": 983, "protein_name": "Spermatogenesis associated 31 subfamily D, member 1E", "gene_name": "Spata31d1e", "organism": "Mouse", "refseq_name": "spermatogenesis-associated protein 31D1", "refseq_ac": [ { "id": "XP_017171161", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017171161", "type": "external" } ], "gene_names_uniprotkb": "Spata31d1e; 1700014D04Rik", "gene_names_refseq": "Spata31d1e", "protein_names_uniprotkb": "Spermatogenesis associated 31 subfamily D, member 1E", "protein_names_refseq": "spermatogenesis-associated protein 31D1", "tax_id": 10090, "disease": "", "pathway": " (mmu:102638268)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "J3QMS2-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2E4-1", "uniprot_id": [ { "id": "Q8R2E4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2E4", "type": "external" } ], "mass": 35106.0, "length": 302, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r37", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor 37", "refseq_ac": [ { "id": "NP_598926", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598926", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r37; Vmn1r35", "gene_names_refseq": "V1rc10; Vmn1r37", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r37; vomeronasal 1 receptor 37; vomeronasal 1 receptor, C10; vomeronasal receptor V1RC10", "tax_id": 10090, "disease": "", "pathway": " (mmu:171183)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016503 pheromone receptor activity;GO:0005550 pheromone binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R2E4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2E3-1", "uniprot_id": [ { "id": "Q8R2E3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2E3", "type": "external" } ], "mass": 35365.0, "length": 305, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r36", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor 36", "refseq_ac": [ { "id": "NP_598927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598927", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r36", "gene_names_refseq": "V1rc11; Vmn1r36", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r36; vomeronasal 1 receptor 36; vomeronasal 1 receptor, C11", "tax_id": 10090, "disease": "", "pathway": " (mmu:171184)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016503 pheromone receptor activity;GO:0005550 pheromone binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R2E3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VFF8-1", "uniprot_id": [ { "id": "Q8VFF8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VFF8", "type": "external" } ], "mass": 34406.0, "length": 303, "protein_name": "Olfactory receptor", "gene_name": "Or4c31", "organism": "Mouse", "refseq_name": "olfactory receptor 1183", "refseq_ac": [ { "id": "NP_666740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666740", "type": "external" } ], "gene_names_uniprotkb": "Or4c31; Olfr1183; Olfr1206", "gene_names_refseq": "MOR230-6; Olfr1183; Or4c31", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-49948903-49949814; olfactory receptor 1183; olfactory receptor MOR230-6", "tax_id": 10090, "disease": "", "pathway": " (mmu:258522)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VFF8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R263-1", "uniprot_id": [ { "id": "Q8R263_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R263", "type": "external" } ], "mass": 34192.0, "length": 300, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r198", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor 198", "refseq_ac": [ { "id": "NP_598981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598981", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r198", "gene_names_refseq": "V1ri3; Vmn1r198", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r198; vomeronasal 1 receptor 198; vomeronasal 1 receptor, I3", "tax_id": 10090, "disease": "", "pathway": " (mmu:171254)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Putative pheromone receptor., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016503 pheromone receptor activity;GO:0005550 pheromone binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R263-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X9T1-1", "uniprot_id": [ { "id": "G3X9T1_MOUSE", "url": "https://www.uniprot.org/uniprot/G3X9T1", "type": "external" } ], "mass": 100727.0, "length": 886, "protein_name": "Zinc finger protein 715", "gene_name": "Zfp715", "organism": "Mouse", "refseq_name": "zinc finger protein 715", "refseq_ac": [ { "id": "NP_081540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081540", "type": "external" } ], "gene_names_uniprotkb": "Zfp715", "gene_names_refseq": "2610041B18Rik; Zfp715; mszf15", "protein_names_uniprotkb": "Zinc finger protein 715", "protein_names_refseq": "zinc finger protein 715", "tax_id": 10090, "disease": "", "pathway": " (mmu:69930); (R-MMU-212436)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3X9T1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ73-1", "uniprot_id": [ { "id": "PKP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ73", "type": "external" } ], "mass": 88104.0, "length": 795, "protein_name": "Plakophilin-2", "gene_name": "Pkp2", "organism": "Mouse", "refseq_name": "plakophilin-2", "refseq_ac": [ { "id": "NP_080439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080439", "type": "external" } ], "gene_names_uniprotkb": "Pkp2", "gene_names_refseq": "1200008D14Rik; 1200012P04Rik; Pkp2l; Pkp2", "protein_names_uniprotkb": "Plakophilin-2", "protein_names_refseq": "plakophilin-2", "tax_id": 10090, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); arrhythmogenic right ventricular dysplasia 9 (Disease Ontology:DOID:0110077)", "pathway": " (mmu:67451); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;15479741;17242355;17535849;18630941;18662195;19144319;25428506;27097650;35959657;37507081;38395410", "class_list": "", "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:15479741). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (By similarity). Required to maintain gingival epithelial barrier function (By similarity). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (By similarity). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (PubMed:15479741). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (PubMed:15479741). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (By similarity). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; By providing an extra link between the cadherin-catenin complex and intermediate filaments, the binding of alphaT-catenin to plakophilin-2 is proposed to be a means of modulating and strengthening cell-cell adhesion between cardiac muscle cells., [RefSeq, PubMed]; Plakophilin 2 is important for the assembly of junctional proteins and represents an essential morphogenic factor and architectural component of the heart, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIY5", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0005080 protein kinase C binding;GO:0045296 cadherin binding;GO:0045294 alpha-catenin binding", "go_cellular_component": "GO:0051286 cell tip;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:1900024 regulation of substrate adhesion-dependent cell spreading;GO:0045110 intermediate filament bundle assembly;GO:0048496 maintenance of animal organ identity;GO:0007267 cell-cell signaling;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9CQ73-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQX8-1", "uniprot_id": [ { "id": "Q7TQX8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQX8", "type": "external" } ], "mass": 35345.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or4k42", "organism": "Mouse", "refseq_name": "olfactory receptor 1290", "refseq_ac": [ { "id": "NP_001265716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265716", "type": "external" } ], "gene_names_uniprotkb": "Or4k42; Olfr1290", "gene_names_refseq": "MOR248-9; Olfr1290; Or4k42", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1290", "tax_id": 10090, "disease": "", "pathway": " (mmu:257662)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TQX8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2U0-1", "uniprot_id": [ { "id": "PSA7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2U0", "type": "external" } ], "mass": 27855.0, "length": 248, "protein_name": "Proteasome subunit alpha type-7", "gene_name": "Psma7", "organism": "Mouse", "refseq_name": "proteasome subunit alpha type-7 isoform 1", "refseq_ac": [ { "id": "NP_036099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036099", "type": "external" } ], "gene_names_uniprotkb": "Psma7", "gene_names_refseq": "C6-I; Psma7", "protein_names_uniprotkb": "Proteasome subunit alpha type-7; Proteasome subunit RC6-1; Proteasome subunit alpha-4; alpha-4", "protein_names_refseq": "alpha-4; proteasome (prosome, macropain) subunit, alpha type 7; proteasome subunit RC6-1; proteasome subunit alpha type-7 isoform 1; proteasome subunit alpha type-7; proteasome subunit alpha-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:26444); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236974); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9912633); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 58, "publication_count": 11, "publication_id_list": "10436176;16317774;16581775;16857966;21750661;22341445;22556278;34428180;37453647;37507081;7522249", "class_list": "", "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000502 proteasome complex", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9Z2U0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3UW87-1", "uniprot_id": [ { "id": "G3UW87_MOUSE", "url": "https://www.uniprot.org/uniprot/G3UW87", "type": "external" } ], "mass": 14156.0, "length": 128, "protein_name": "Predicted gene, 17455", "gene_name": "Gm17455", "organism": "Mouse", "refseq_name": "uncharacterized protein C10orf105 homolog", "refseq_ac": [ { "id": "NP_001157846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157846", "type": "external" } ], "gene_names_uniprotkb": "Gm17455", "gene_names_refseq": "Gm17455", "protein_names_uniprotkb": "Predicted gene, 17455", "protein_names_refseq": "uncharacterized protein C10orf105 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:100302688)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3UW87-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6SKR2-1", "uniprot_id": [ { "id": "HEMK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6SKR2", "type": "external" } ], "mass": 22984.0, "length": 214, "protein_name": "Methyltransferase HEMK2", "gene_name": "Hemk2", "organism": "Mouse", "refseq_name": "methyltransferase HEMK2 isoform 2", "refseq_ac": [ { "id": "NP_001152803", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152803", "type": "external" } ], "gene_names_uniprotkb": "Hemk2; Kmt9; N6amt1; Pred28", "gene_names_refseq": "5830445C04Rik; Hemk2; N6amt1; Pred28", "protein_names_uniprotkb": "Methyltransferase HEMK2; 2.1.1.-; HemK methyltransferase family member 2; Lysine N-methyltransferase 9; M.HsaHemK2P; Methylarsonite methyltransferase N6AMT1; Methyltransferase N6AMT1; Protein N(5)-glutamine methyltransferase", "protein_names_refseq": "HemK methyltransferase family member 2; M-N6DNA MTase A; M.HsaHemK2P; N(6)-adenine-specific DNA methyltransferase 1; N-6 adenine-specific DNA methyltransferase 1 (putative); N6-DNA methyltransferase A; lysine N-methyltransferase 9; methylarsonite methyltransferase N6AMT1; methyltransferase HEMK2 isoform 2; methyltransferase HEMK2; protein N(5)-glutamine methyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:67768); (R-MMU-156581); (R-MMU-72764)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "16684535;18389380;19116772;20606008;21750661;26797129;37624905", "class_list": "", "function": "DNA N6-methyladenine methylase N6AMT1 controls neuropathic pain through epigenetically modifying Kcnj16 in dorsal horn neurons., [RefSeq, PubMed]; Disruption of N6amt1 gene led to early embryonic lethality., [RefSeq, PubMed]; HEMK2 requires a GQX3R motif for methylation activity., [RefSeq, PubMed]; Methyltransferase that can methylate proteins and, to a lower extent, arsenic (PubMed:20606008, PubMed:26797129). Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators (By similarity). Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif (PubMed:26797129). Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated (PubMed:20606008, PubMed:26797129). May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid (By similarity). It however only plays a limited role in arsenic metabolism compared with AS3MT (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Methyltransferase that can methylate proteins and, to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. It however only plays a limited role in arsenic metabolism compared with AS3MT., [UniProtKB, UniProtKB]; Suggested that mN6A1 participates in protein translation through interaction with eRF1, [RefSeq, PubMed]; The murine PRED28 encodes two alternatively spliced RNA., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3Z6J0;E9PXT7;Q4KMV5;Q6PRU9", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0008276 protein methyltransferase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0030791 arsenite methyltransferase activity;GO:1904047 S-adenosyl-L-methionine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0035657 eRF1 methyltransferase complex", "go_biological_process": "GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0009404 toxin metabolic process;GO:0045814 negative regulation of gene expression, epigenetic;GO:0018872 arsonoacetate metabolic process;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6SKR2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U425-1", "uniprot_id": [ { "id": "SGSN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5U425", "type": "external" } ], "mass": 7757.0, "length": 68, "protein_name": "Small integral membrane protein 10-like protein 3", "gene_name": "Smim10l3", "organism": "Mouse", "refseq_name": "small integral membrane protein 10-like protein 3", "refseq_ac": [ { "id": "NP_001382923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001382923", "type": "external" } ], "gene_names_uniprotkb": "Smim10l3; Sagsin1", "gene_names_refseq": "Sagsin1; Smim10l3", "protein_names_uniprotkb": "Small integral membrane protein 10-like protein 3; Salivary gland-specific protein SAGSIN1", "protein_names_refseq": "salivary gland specific protein SAGSIN1; small integral membrane protein 10-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:122526778); (mmu:67238)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "19659802", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U425-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A075B680-1", "uniprot_id": [ { "id": "A0A075B680_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A075B680", "type": "external" } ], "mass": 11225.0, "length": 100, "protein_name": "Immunoglobulin heavy variable 1-62-2; Immunoglobulin heavy variable 1-71", "gene_name": "Ighv1-62-2; Ighv1-71", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighv1-62-2; Ighv1-71; Ighv1-71", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy variable 1-62-2; Immunoglobulin heavy variable 1-71", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-173623); (R-MMU-198933); (R-MMU-202733); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-2168880); (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-2871837); (R-MMU-5690714); (R-MMU-977606); (R-MMU-983695)", "pathway_count": 15, "publication_count": 2, "publication_id_list": "21750661;40997131", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0002250 adaptive immune response;GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A075B680-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AEV7-1", "uniprot_id": [ { "id": "CC120_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AEV7", "type": "external" } ], "mass": 67407.0, "length": 629, "protein_name": "Coiled-coil domain-containing protein 120", "gene_name": "Ccdc120", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 120", "refseq_ac": [ { "id": "NP_997085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997085", "type": "external" } ], "gene_names_uniprotkb": "Ccdc120", "gene_names_refseq": "Ccdc120; DXImx50e; Jm11; Sfc25", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 120", "protein_names_refseq": "coiled-coil domain-containing protein 120", "tax_id": 10090, "disease": "", "pathway": " (mmu:54648)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17242355;21183079;21750661;24129315;28422092", "class_list": "", "function": "Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth (By similarity). Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AEV8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005768 endosome;GO:0030426 growth cone;GO:0005814 centriole;GO:0120103 centriolar subdistal appendage", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0034454 microtubule anchoring at centrosome", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A2AEV7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9Y8-1", "uniprot_id": [ { "id": "SSMM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9Y8", "type": "external" } ], "mass": 27935.0, "length": 244, "protein_name": "Serine-rich single-pass membrane protein 1", "gene_name": "Ssmem1", "organism": "Mouse", "refseq_name": "serine-rich single-pass membrane protein 1 isoform b", "refseq_ac": [ { "id": "NP_083649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083649", "type": "external" } ], "gene_names_uniprotkb": "Ssmem1; 1700025E21Rik", "gene_names_refseq": "1700016K02Rik; 1700025E21Rik; Ssmem1", "protein_names_uniprotkb": "Serine-rich single-pass membrane protein 1", "protein_names_refseq": "serine-rich single-pass membrane protein 1 isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:75647)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;32301969", "class_list": "", "function": "Essential for regulating the timely and localized migration of the Golgi apparatus during spermiogenesis, facilitating proper sperm head formation and motility, thus playing a crucial role in male fertility., [UniProtKB, PubMed]; Knockout of serine-rich single-pass membrane protein 1 (Ssmem1) causes globozoospermia and sterility in male micedagger., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q78FQ7;Q9DAA0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D9Y8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TR16-1", "uniprot_id": [ { "id": "Q7TR16_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TR16", "type": "external" } ], "mass": 34377.0, "length": 303, "protein_name": "Olfactory receptor", "gene_name": "Or4c100", "organism": "Mouse", "refseq_name": "olfactory receptor 1186", "refseq_ac": [ { "id": "NP_666741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666741", "type": "external" } ], "gene_names_uniprotkb": "Or4c100; Olfr1186", "gene_names_refseq": "MOR230-5; Olfr1186; Or4c100", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-50012960-50013871; olfactory receptor 1186; olfactory receptor MOR230-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:258523)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TQS4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AQA0-1", "uniprot_id": [ { "id": "A2AQA0_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AQA0", "type": "external" } ], "mass": 77634.0, "length": 667, "protein_name": "Zinc finger protein 442", "gene_name": "Zfp442", "organism": "Mouse", "refseq_name": "zinc finger protein 442", "refseq_ac": [ { "id": "NP_001297574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297574", "type": "external" } ], "gene_names_uniprotkb": "Zfp442", "gene_names_refseq": "ZIPO-II; Zfp442", "protein_names_uniprotkb": "Zinc finger protein 442", "protein_names_refseq": "zinc finger protein 442; zinc-finger protein in podocyte II", "tax_id": 10090, "disease": "", "pathway": " (mmu:668923)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2AQA0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6ZNL5-1", "uniprot_id": [ { "id": "F6ZNL5_MOUSE", "url": "https://www.uniprot.org/uniprot/F6ZNL5", "type": "external" } ], "mass": 147330.0, "length": 1338, "protein_name": "Protocadherin 11 X-linked", "gene_name": "Pcdh11x", "organism": "Mouse", "refseq_name": "protocadherin-11 X-linked isoform c precursor", "refseq_ac": [ { "id": "NP_001390563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001390563", "type": "external" } ], "gene_names_uniprotkb": "Pcdh11x", "gene_names_refseq": "PCDHX11; PCDHX; Pcdh11x; Pcdh11", "protein_names_uniprotkb": "Protocadherin 11 X-linked", "protein_names_refseq": "protocadherin X-linked 11; protocadherin-11 X-linked isoform c precursor", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "Potential calcium-dependent cell-adhesion protein., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of the protocadherin family, and cadherin superfamily, of transmembrane proteins containing cadherin domains. The encoded protein may mediate cell-cell adhesion in neuronal tissues in the presence of calcium. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2012]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0061827 sperm head;GO:0005886 plasma membrane;GO:0097225 sperm midpiece", "go_biological_process": "GO:0007155 cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "F6ZNL5-1", "record_type": "protein", "filter_code": "0000000.1000110.010000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q732-1", "uniprot_id": [ { "id": "E9Q732_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q732", "type": "external" } ], "mass": 70103.0, "length": 603, "protein_name": "Zinc finger protein 949", "gene_name": "Zfp949", "organism": "Mouse", "refseq_name": "uncharacterized protein LOC71640", "refseq_ac": [ { "id": "NP_001136415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136415", "type": "external" } ], "gene_names_uniprotkb": "Zfp949", "gene_names_refseq": "4930422I07Rik; Nczf; Zfp949", "protein_names_uniprotkb": "Zinc finger protein 949", "protein_names_refseq": "uncharacterized protein LOC71640", "tax_id": 10090, "disease": "", "pathway": " (mmu:71640)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;27196371;30059200;34887587", "class_list": "", "function": "Nczf is essential for embryonic development and cell proliferation by negatively regulating p27 mRNA expression in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "E9Q732-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A087WP44-1", "uniprot_id": [ { "id": "A0A087WP44_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A087WP44", "type": "external" } ], "mass": 25622.0, "length": 222, "protein_name": "Predicted gene 28827; Predicted gene 28897; Predicted gene 29110; Predicted gene 29564; Predicted gene, 21760; Predicted gene, 31571", "gene_name": "Gm29564; Gm31571", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gm29564; Gm31571; Gm21760; Gm28827; Gm28897; Gm29110; Gm29564; Gm31571", "gene_names_refseq": "", "protein_names_uniprotkb": "Predicted gene 28827; Predicted gene 28897; Predicted gene 29110; Predicted gene 29564; Predicted gene, 21760; Predicted gene, 31571", "protein_names_refseq": "", "tax_id": 10090, "disease": "spermatogenic failure 4 (Disease Ontology:DOID:0070176)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0007286 spermatid development;GO:0051321 meiotic cell cycle;GO:0035092 sperm DNA condensation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A087WP44-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VGM0-1", "uniprot_id": [ { "id": "Q8VGM0_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VGM0", "type": "external" } ], "mass": 34316.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or13a26", "organism": "Mouse", "refseq_name": "olfactory receptor family 13 subfamily A member 26", "refseq_ac": [ { "id": "NP_667173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_667173", "type": "external" } ], "gene_names_uniprotkb": "Or13a26; Olfr541", "gene_names_refseq": "MOR253-3; Olfr541; Or13a26", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PBJ9-42850324-42851256; olfactory receptor 541; olfactory receptor MOR253-3; olfactory receptor family 13 subfamily A member 26", "tax_id": 10090, "disease": "", "pathway": " (mmu:258964)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Possible taste receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007608 sensory perception of smell;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VGM0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VU7-1", "uniprot_id": [ { "id": "PUS7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VU7", "type": "external" } ], "mass": 74793.0, "length": 660, "protein_name": "Pseudouridylate synthase 7 homolog", "gene_name": "Pus7", "organism": "Mouse", "refseq_name": "pseudouridylate synthase 7 homolog isoform 1", "refseq_ac": [ { "id": "NP_001276709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276709", "type": "external" } ], "gene_names_uniprotkb": "Pus7; Kiaa1897", "gene_names_refseq": "C330017I15Rik; Pus7", "protein_names_uniprotkb": "Pseudouridylate synthase 7 homolog; 5.4.99.-", "protein_names_refseq": "pseudouridylate synthase 7 homolog isoform 1; pseudouridylate synthase 7 homolog", "tax_id": 10090, "disease": "intellectual developmental disorder with abnormal behavior, microcephaly, and short stature (Disease Ontology:DOID:0081265); intellectual disability (Disease Ontology:DOID:1059); microcephaly (Disease Ontology:DOID:10907)", "pathway": " (mmu:78697)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "18299400;21750661;21952136;25153642;25428506;28528544;30779550;34428180;35820727", "class_list": "", "function": "Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZNL8;F7AC41;Q3TUC7;Q3UQN6;Q69Z76", "ec_number_list": [ { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" }, { "id": "5.4.99.42", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.42", "type": "external" }, { "id": "5.4.99.28", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.28", "type": "external" }, { "id": "5.4.99.25", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.25", "type": "external" }, { "id": "5.4.99.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.12", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0019899 enzyme binding;GO:0009982 pseudouridine synthase activity;GO:0160150 tRNA pseudouridine(13) synthase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0031119 tRNA pseudouridine synthesis;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:1902036 regulation of hematopoietic stem cell differentiation;GO:0017148 negative regulation of translation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q91VU7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQB5-1", "uniprot_id": [ { "id": "Q9EQB5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQB5", "type": "external" } ], "mass": 35861.0, "length": 319, "protein_name": "Olfactory receptor", "gene_name": "Or8g28", "organism": "Mouse", "refseq_name": "olfactory receptor family 8 subfamily G member 28", "refseq_ac": [ { "id": "NP_666717", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666717", "type": "external" } ], "gene_names_uniprotkb": "Or8g28; Olfr945", "gene_names_refseq": "MOR171-20; Olfr945; Or8g28", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PVTD-32955932-32954982; olfactory receptor 945; olfactory receptor MOR171-20; olfactory receptor family 8 subfamily G member 28", "tax_id": 10090, "disease": "", "pathway": " (mmu:258499)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9EQB5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3QP37-1", "uniprot_id": [ { "id": "J3QP37_MOUSE", "url": "https://www.uniprot.org/uniprot/J3QP37", "type": "external" } ], "mass": 10199.0, "length": 91, "protein_name": "Small integral membrane protein 22", "gene_name": "Smim22", "organism": "Mouse", "refseq_name": "small integral membrane protein 22 isoform 1", "refseq_ac": [ { "id": "NP_001240725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240725", "type": "external" } ], "gene_names_uniprotkb": "Smim22; Gm5480", "gene_names_refseq": "EG432995; Gm5480; Smim22", "protein_names_uniprotkb": "Small integral membrane protein 22", "protein_names_refseq": "small integral membrane protein 22 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:432995)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0032956 regulation of actin cytoskeleton organization;GO:0042127 regulation of cell population proliferation;GO:0140042 lipid droplet formation;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "J3QP37-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VGU4-1", "uniprot_id": [ { "id": "VGF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0VGU4", "type": "external" } ], "mass": 68232.0, "length": 617, "protein_name": "Neurosecretory protein VGF", "gene_name": "Vgf", "organism": "Mouse", "refseq_name": "neurosecretory protein VGF precursor", "refseq_ac": [ { "id": "NP_001034474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034474", "type": "external" } ], "gene_names_uniprotkb": "Vgf", "gene_names_refseq": "Gm1052; Vgf", "protein_names_uniprotkb": "Neurosecretory protein VGF", "protein_names_refseq": "neurosecretory protein VGF precursor; neurosecretory protein VGF", "tax_id": 10090, "disease": "", "pathway": " (mmu:381677); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "16141392;19863797;21750661;22289198;22645316;25456411;25917832;26180209;30504797;34203471;37482186", "class_list": "", "function": "Modulation of VGF levels and/or VGF signaling may consequently represent an alternative means to regulate circulating glucose levels and insulin sensitivity., [RefSeq, PubMed]; Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons (By similarity). Also stimulates feeding behavior in an orexin-dependent manner in the hypothalamus (By similarity). Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying (By similarity)., [UniProtKB, UniProtKB]; Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons., [UniProtKB, UniProtKB]; Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation (PubMed:26180209, PubMed:30504797). Also induces insulin secretion in insulinoma cells by increasing intracellular calcium mobilization (PubMed:25917832)., [UniProtKB, PubMed, PubMed, PubMed]; Secreted multifunctional peptide that interacts with different receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation as well as lipolysis (PubMed:22289198, PubMed:25456411). Activates the G protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes (PubMed:25456411). Interacts with gC1qR receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (PubMed:19863797, PubMed:26180209, PubMed:30504797)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0043025 neuronal cell body", "go_biological_process": "GO:0033500 carbohydrate homeostasis;GO:0006091 generation of precursor metabolites and energy;GO:0009409 response to cold;GO:0048167 regulation of synaptic plasticity;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q0VGU4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6UAH1-1", "uniprot_id": [ { "id": "Q6UAH1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6UAH1", "type": "external" } ], "mass": 34786.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or2h1b", "organism": "Mouse", "refseq_name": "olfactory receptor family 2 subfamily H member 1B", "refseq_ac": [ { "id": "NP_001011813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011813", "type": "external" } ], "gene_names_uniprotkb": "Or2h1b; Olfr93", "gene_names_refseq": "MOR256-39P; Olfr93; Or2h1b", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PSCP-1592036-1591098; olfactory receptor 93; olfactory receptor MOR256-39P; olfactory receptor family 2 subfamily H member 1B", "tax_id": 10090, "disease": "", "pathway": " (mmu:258051)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;27802388", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6UAH1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E8H5-1", "uniprot_id": [ { "id": "G5E8H5_MOUSE", "url": "https://www.uniprot.org/uniprot/G5E8H5", "type": "external" } ], "mass": 76705.0, "length": 664, "protein_name": "Transmembrane phosphatase with tensin homology", "gene_name": "Tpte", "organism": "Mouse", "refseq_name": "transmembrane phosphatase with tensin homology", "refseq_ac": [ { "id": "NP_954866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954866", "type": "external" } ], "gene_names_uniprotkb": "Tpte", "gene_names_refseq": "Pten2; 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Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0008135 translation factor activity, RNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005851 eukaryotic translation initiation factor 2B complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0050852 T cell receptor signaling pathway;GO:0006413 translational initiation;GO:0009749 response to glucose;GO:0043434 response to peptide hormone", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B1AUN2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VEZ7-1", "uniprot_id": [ { "id": "Q8VEZ7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VEZ7", "type": "external" } ], "mass": 34915.0, "length": 311, "protein_name": "Olfactory receptor", "gene_name": "Or1e30", "organism": "Mouse", "refseq_name": "olfactory receptor family 1 subfamily E member 30", "refseq_ac": [ { "id": "NP_666459", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666459", "type": "external" } ], "gene_names_uniprotkb": "Or1e30; Olfr390", "gene_names_refseq": "MOR135-26; Olfr390; Or1e30", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2P1NL-3938806-3939741; olfactory receptor 390; olfactory receptor MOR135-26; olfactory receptor family 1 subfamily E member 30", "tax_id": 10090, "disease": "", "pathway": " (mmu:258344); (R-MMU-381753)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Results show that Olfr43 activates the PKA-CREB pathway in mouse hepatocytes. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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It recognizes the sequence R-G-D in its ligands (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (PubMed:25127859). Required during vasculogenesis (PubMed:12050137, PubMed:16251442)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Integrin beta8 is required for vascular morphogenesis by providing proper cues for capillary growth in both yolk sac and embryonic brain (integrin beta8), [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990430 extracellular matrix protein binding;GO:0005102 signaling receptor binding;GO:0005178 integrin binding;GO:0015026 coreceptor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0008305 integrin complex;GO:0034686 integrin alphav-beta8 complex", "go_biological_process": "GO:0001570 vasculogenesis;GO:0006955 immune response;GO:0007229 integrin-mediated signaling pathway;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q0VBD0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UW43-1", "uniprot_id": [ { "id": "SG11B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UW43", "type": "external" } ], "mass": 12857.0, "length": 113, "protein_name": "Sperm-associated antigen 11B", "gene_name": "Spag11b", "organism": "Mouse", "refseq_name": "sperm-associated antigen 11B isoform c precursor", "refseq_ac": [ { "id": "NP_001034652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034652", "type": "external" } ], "gene_names_uniprotkb": "Spag11b; Ep2; Spag11c; h", "gene_names_refseq": "Bin1b; EG546038; Ep2c/h; Ep2e; Spag11b; Spag11c/h; Spag11", "protein_names_uniprotkb": "Sperm-associated antigen 11B; Protein EP2", "protein_names_refseq": "Sperm-associated antigen 11; beta-defensin-like peptide; sperm-associated antigen 11B isoform c precursor; sperm-associated antigen 11c/h", "tax_id": 10090, "disease": "", "pathway": " (mmu:546038)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16033865", "class_list": "", "function": "Has antimicrobial activity against E.coli (By similarity). Plays a role in the defense response in the male reproductive tract, contributing to sperm maturation, storage and protection (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2HPE2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3UW43-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQT0-1", "uniprot_id": [ { "id": "Q7TQT0_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQT0", "type": "external" } ], "mass": 34429.0, "length": 309, "protein_name": "Olfactory receptor", "gene_name": "Or2y1c", "organism": "Mouse", "refseq_name": "olfactory receptor 1386", "refseq_ac": [ { "id": "NP_001011741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011741", "type": "external" } ], "gene_names_uniprotkb": "Or2y1c; Olfr1386", "gene_names_refseq": "MOR256-50; Olfr1386; Or2y1c", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2QP88-5964781-5963852; olfactory receptor 1386; olfactory receptor MOR256-50", "tax_id": 10090, "disease": "", "pathway": " (mmu:257888)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25635859;38809710", "class_list": "", "function": "NAD activates olfactory receptor 1386 to regulate type I interferon responses in Plasmodium yoelii YM infection., [RefSeq, PubMed]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Three olfactory receptors (olfr544, olfr558, and olfr1386) were expressed in the olfactory marker protein (+) cells of the bladder and thyroid. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TQT0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQY6-1", "uniprot_id": [ { "id": "Q7TQY6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQY6", "type": "external" } ], "mass": 34538.0, "length": 305, "protein_name": "Olfactory receptor", "gene_name": "Or4k37", "organism": "Mouse", "refseq_name": "olfactory receptor family 4 subfamily K member 37", "refseq_ac": [ { "id": "NP_001005568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005568", "type": "external" } ], "gene_names_uniprotkb": "Or4k37; Olfr1281", "gene_names_refseq": "MOR248-14P; MOR248-18; Olfr1281; Or4k37", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-72379864-72380781; olfactory receptor 1281; olfactory receptor MOR248-14P; olfactory receptor family 4 subfamily K member 37", "tax_id": 10090, "disease": "", "pathway": " (mmu:257979)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TQY6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQY8-1", "uniprot_id": [ { "id": "Q7TQY8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQY8", "type": "external" } ], "mass": 35564.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or4f52", "organism": "Mouse", "refseq_name": "olfactory receptor family 4 subfamily F member 52", "refseq_ac": [ { "id": "NP_001011795", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011795", "type": "external" } ], "gene_names_uniprotkb": "Or4f52; Olfr1275", "gene_names_refseq": "MOR245-18; Olfr1275; Or4f52", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-72283260-72282322; olfactory receptor 1275; olfactory receptor MOR245-18; olfactory receptor family 4 subfamily F member 52", "tax_id": 10090, "disease": "", "pathway": " (mmu:257980)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TQY8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TR59-1", "uniprot_id": [ { "id": "Q7TR59_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TR59", "type": "external" } ], "mass": 34826.0, "length": 310, "protein_name": "Olfactory receptor", "gene_name": "Or5t16", "organism": "Mouse", "refseq_name": "olfactory receptor 1101", "refseq_ac": [ { "id": "NP_666802", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666802", "type": "external" } ], "gene_names_uniprotkb": "Or5t16; Olfr1101", "gene_names_refseq": "MOR179-3; Olfr1101; Or5t16", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-48475870-48474938; olfactory receptor 1101; olfactory receptor MOR179-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:258584)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TR59-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TR84-1", "uniprot_id": [ { "id": "Q7TR84_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TR84", "type": "external" } ], "mass": 36144.0, "length": 321, "protein_name": "Olfactory receptor", "gene_name": "Or8u10", "organism": "Mouse", "refseq_name": "olfactory receptor 1037", "refseq_ac": [ { "id": "NP_001011532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011532", "type": "external" } ], "gene_names_uniprotkb": "Or8u10; Olfr1037", "gene_names_refseq": "MOR171-52; MOR256-34P; Olfr1037; Or8u10", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-47560740-47559775; olfactory receptor 1037; olfactory receptor MOR256-34P", "tax_id": 10090, "disease": "", "pathway": " (mmu:259151)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Publication Status: Online-Only, [RefSeq, PubMed]; GPR15LG regulates psoriasis-like inflammation by down-regulating inflammatory factors on keratinocytes., [RefSeq, PubMed]; Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus., [UniProtKB, UniProtKB]; Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G protein-coupled receptor GPR15 (PubMed:28900043, PubMed:28936214). May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (By similarity). May regulate keratinocyte proliferation. In addition, through activation of Mas-related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation (PubMed:35704588)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0048018 receptor ligand activity;GO:0008009 chemokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0050830 defense response to Gram-positive bacterium;GO:0048247 lymphocyte chemotaxis;GO:0043029 T cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A0B4J1N3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A140LHT7-1", "uniprot_id": [ { "id": "A0A140LHT7_MOUSE", "url": "https://www.uniprot.org/uniprot/A0A140LHT7", "type": "external" } ], "mass": 35801.0, "length": 321, "protein_name": "Olfactory receptor", "gene_name": "Or5bb12", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Or5bb12; 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Olfr739", "gene_names_refseq": "MOR106-2; Olfr739; Or11g24", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2PMLR-6121675-6122604; olfactory receptor 739; olfactory receptor MOR106-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:258663)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Olfr110/111 and Olfr544 proteins are mainly expressed by neurons in cortical and hippocampal regions and, to a lesser extent, by glia and endothelial cells. expression of the mRNA encoding for Olfr110/111 tends to increase with age in both the cortex and hippocampus of wild-type and transgenic mice. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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