[ { "uniprot_canonical_ac": "P02452-1", "uniprot_id": [ { "id": "CO1A1_HUMAN", "url": "https://www.uniprot.org/uniprot/P02452", "type": "external" } ], "mass": 138911.0, "length": 1464, "protein_name": "Collagen alpha-1(I) chain", "gene_name": "COL1A1", "organism": "Human", "refseq_name": "collagen alpha-1(I) chain preproprotein", "refseq_ac": [ { "id": "NP_000079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000079", "type": "external" } ], "gene_names_uniprotkb": "COL1A1", "gene_names_refseq": "CAFYD; COL1A1; EDSARTH1; EDSC; OI1; OI2; OI3; OI4", "protein_names_uniprotkb": "Collagen alpha-1(I) chain; Alpha-1 type I collagen", "protein_names_refseq": "alpha-1 type I collagen; alpha1(I) procollagen; collagen Col1-ColIII-1; collagen Col1-ColIII-2; collagen alpha 1 chain type I; collagen alpha-1(I) chain preproprotein; collagen of skin, tendon and bone, alpha-1 chain; collagen, type I, alpha 1; pro-alpha-1 collagen type 1; type I proalpha 1; type I procollagen alpha 1 chain", "tax_id": 9606, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); chronic pancreatitis (Disease Ontology:DOID:0051065); maple syrup urine disease type IB (Disease Ontology:DOID:0061206); lupus nephritis (Disease Ontology:DOID:0080162); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); Ehlers-Danlos syndrome arthrochalasia type 1 (Disease Ontology:DOID:0080727); osteogenesis imperfecta type 1 (Disease Ontology:DOID:0110334); osteogenesis imperfecta type 3 (Disease Ontology:DOID:0110339); osteogenesis imperfecta type 4 (Disease Ontology:DOID:0110340); osteogenesis imperfecta type 2 (Disease Ontology:DOID:0110341); osteoporosis (Disease Ontology:DOID:11476); otosclerosis (Disease Ontology:DOID:12185); primary biliary cholangitis (Disease Ontology:DOID:12236); beta thalassemia (Disease Ontology:DOID:12241); osteogenesis imperfecta (Disease Ontology:DOID:12347); alcoholic hepatitis (Disease Ontology:DOID:12351); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); cholestasis (Disease Ontology:DOID:13580); bladder neck obstruction (Disease Ontology:DOID:13948); thoracic aortic aneurysm (Disease Ontology:DOID:14004); Ehlers-Danlos syndrome classic type 1 (Disease Ontology:DOID:14720); aggressive periodontitis (Disease Ontology:DOID:1474); multiple sclerosis (Disease Ontology:DOID:2377); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); dermatofibrosarcoma protuberans (Disease Ontology:DOID:3507); pulmonary fibrosis (Disease Ontology:DOID:3770); dentinogenesis imperfecta (Disease Ontology:DOID:4154); systemic scleroderma (Disease Ontology:DOID:418); Caffey disease (Disease Ontology:DOID:4257); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); osteoarthritis (Disease Ontology:DOID:8398); ulcerative colitis (Disease Ontology:DOID:8577); degenerative disc disease (Disease Ontology:DOID:90); cutaneous leishmaniasis (Disease Ontology:DOID:9111); liver benign neoplasm (Disease Ontology:DOID:916); maple syrup urine disease (Disease Ontology:DOID:9269); obesity (Disease Ontology:DOID:9970); combined osteogenesis imperfecta and Ehlers-Danlos syndrome 1 (MONDO:MONDO:0030854)", "pathway": " (hsa:1277); (R-HSA-114604); (R-HSA-1442490); (R-HSA-1566977); (R-HSA-1650814); (R-HSA-198933); (R-HSA-2022090); (R-HSA-202733); (R-HSA-216083); (R-HSA-2214320); (R-HSA-2243919); (R-HSA-3000170); (R-HSA-3000171); (R-HSA-3000178); (R-HSA-3000480); (R-HSA-430116); (R-HSA-75892); (R-HSA-76009); (R-HSA-8874081); (R-HSA-8940973); (R-HSA-8948216); (R-HSA-9845619); (R-HSA-9845620); (R-HSA-9845621); (R-HSA-9845622); (R-HSA-9846298); (R-HSA-9925563)", "pathway_count": 27, "publication_count": 652, "publication_id_list": 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"class_list": "glycogene", "function": "CircCOL1A1 promotes proliferation, migration, and invasion of colorectal cancer (CRC) cells and glutamine metabolism through GLS1 up-regulation by sponging miR-214-3p. Publication Status: Online-Only, [RefSeq, PubMed]; Expression, prognostic value and potential immunotherapeutic target of COL1A1 in colon cancer. Publication Status: Online-Only, [RefSeq, PubMed]; FEATURES OF COL1A1 EXPRESSION IN BREAST CANCER TISSUE OF YOUNG PATIENTS. Publication Status: Online-Only, [RefSeq, PubMed]; Genetic Polymorphisms of COL1A1 Promoter Region (rs1800012) and TGFB1 Signal Peptide (rs1800471): Role in Cervical Insufficiency Susceptibility?, [RefSeq, PubMed]; This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]., [RefSeq]; Type I collagen is a member of group I collagen (fibrillar forming collagen)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 12, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 13, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 13, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 21, "disease_count": 42, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "O76045;P78441;Q13896;Q13902;Q13903;Q14037;Q14992;Q15176;Q15201;Q16050;Q59F64;Q7KZ30;Q7KZ34;Q8IVI5;Q8N473;Q9UML6;Q9UMM7", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0030020 extracellular matrix structural constituent conferring tensile strength;GO:0048407 platelet-derived growth factor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0030141 secretory granule;GO:0031012 extracellular matrix", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0071300 cellular response to retinoic acid;GO:0071333 cellular response to glucose stimulus;GO:0042542 response to hydrogen peroxide;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 68.8, "record_id": "P02452-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000001000000.1100000001001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04637-1", "uniprot_id": [ { "id": "P53_HUMAN", "url": "https://www.uniprot.org/uniprot/P04637", "type": "external" } ], "mass": 43653.0, "length": 393, "protein_name": "Cellular tumor antigen p53", "gene_name": "TP53", "organism": "Human", "refseq_name": "cellular tumor antigen p53 isoform a", "refseq_ac": [ { "id": "NP_000537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000537", "type": "external" } ], "gene_names_uniprotkb": "TP53; P53", "gene_names_refseq": "BCC7; BMFS5; LFS1; P53; TP53; TRP53", "protein_names_uniprotkb": "Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53", "protein_names_refseq": "antigen NY-CO-13; cellular tumor antigen p53 isoform a; cellular tumor antigen p53; mutant tumor protein 53; phosphoprotein p53; transformation-related protein 53; tumor protein 53; tumor supressor p53", "tax_id": 9606, "disease": "angiosarcoma (Disease Ontology:DOID:0001816); pterygium (Disease Ontology:DOID:0002116); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); CHARGE syndrome (Disease Ontology:DOID:0050834); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); medulloblastoma (Disease Ontology:DOID:0050902); myelodysplastic syndrome (Disease Ontology:DOID:0050908); pre-malignant neoplasm (Disease Ontology:DOID:0060071); ductal carcinoma in situ (Disease Ontology:DOID:0060074); colorectal carcinoma (Disease Ontology:DOID:0080199); adenoid cystic carcinoma (Disease Ontology:DOID:0080202); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); graft-versus-host disease (Disease Ontology:DOID:0081267); traumatic brain injury (Disease Ontology:DOID:0081292); T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0081312); Li-Fraumeni syndrome 1 (Disease Ontology:DOID:0111503); mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); prostate cancer (Disease Ontology:DOID:10283); aggressive NK-cell leukemia (Disease Ontology:DOID:1035); stomach cancer (Disease Ontology:DOID:10534); primary open angle glaucoma (Disease Ontology:DOID:1070); nasal cavity cancer (Disease Ontology:DOID:10811); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); sarcoma (Disease Ontology:DOID:1115); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); Graves' disease (Disease Ontology:DOID:12361); leukemia (Disease Ontology:DOID:1240); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); paranasal sinus benign neoplasm (Disease Ontology:DOID:1350); low tension glaucoma (Disease Ontology:DOID:13544); endometrial cancer (Disease Ontology:DOID:1380); disease of cellular proliferation (Disease Ontology:DOID:14566); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); basal cell carcinoma (Disease Ontology:DOID:2513); hematologic cancer (Disease Ontology:DOID:2531); choroid plexus papilloma (Disease Ontology:DOID:2626); transitional cell carcinoma (Disease Ontology:DOID:2671); dyskeratosis congenita (Disease Ontology:DOID:2729); endometrial adenocarcinoma (Disease Ontology:DOID:2870); endometrial carcinoma (Disease Ontology:DOID:2871); testicular cancer (Disease Ontology:DOID:2998); Li-Fraumeni syndrome (Disease Ontology:DOID:3012); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); serous cystadenocarcinoma (Disease Ontology:DOID:3114); ischemia (Disease Ontology:DOID:326); osteosarcoma (Disease Ontology:DOID:3347); coronary artery disease (Disease Ontology:DOID:3393); cervical adenocarcinoma (Disease Ontology:DOID:3702); gastric adenocarcinoma (Disease Ontology:DOID:3717); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); adrenocortical carcinoma (Disease Ontology:DOID:3948); papillary thyroid carcinoma (Disease Ontology:DOID:3969); coronary restenosis (Disease Ontology:DOID:4247); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); myelofibrosis (Disease Ontology:DOID:4971); esophageal cancer (Disease Ontology:DOID:5041); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); ovary serous adenocarcinoma (Disease Ontology:DOID:5744); oral submucous fibrosis (Disease Ontology:DOID:5773); malignant peripheral nerve sheath tumor (Disease Ontology:DOID:5940); hepatocellular carcinoma (Disease Ontology:DOID:684); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); pancreatic intraductal papillary-mucinous neoplasm (Disease Ontology:DOID:7575); meninges sarcoma (Disease Ontology:DOID:7614); vascular dementia (Disease Ontology:DOID:8725); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); multiple myeloma (Disease Ontology:DOID:9538); oral mucosa leukoplakia (Disease Ontology:DOID:9655); basal cell carcinoma, susceptibility to, 7 (MONDO:MONDO:0013876); bone marrow failure syndrome 5 (MONDO:MONDO:0032573)", "pathway": " (hsa:7157); (R-HSA-111448); (R-HSA-139915); (R-HSA-1912408); (R-HSA-2559580); (R-HSA-2559584); (R-HSA-2559585); (R-HSA-2559586); (R-HSA-3232118); (R-HSA-349425); (R-HSA-390471); (R-HSA-5620971); (R-HSA-5628897); (R-HSA-5689880); (R-HSA-5689896); (R-HSA-5693565); (R-HSA-6785807); (R-HSA-6796648); (R-HSA-6803204); (R-HSA-6803205); (R-HSA-6803207); (R-HSA-6803211); (R-HSA-6804114); (R-HSA-6804115); (R-HSA-6804116); (R-HSA-6804754); (R-HSA-6804756); (R-HSA-6804757); (R-HSA-6804758); (R-HSA-6804759); (R-HSA-6804760); (R-HSA-6811555); (R-HSA-69473); (R-HSA-69481); (R-HSA-69541); (R-HSA-69895); (R-HSA-70635); (R-HSA-8852276); (R-HSA-8853884); (R-HSA-8941855); (R-HSA-8943724); (R-HSA-9723905); (R-HSA-9725370); (R-HSA-9758274); (R-HSA-9819196); (R-HSA-983231); (R-HSA-9833482)", "pathway_count": 47, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Common genetic variants in the TP53 pathway and their impact on cancer. Review article, [RefSeq, PubMed]; Harbouring alternative translation initiation sites, the p53 mRNA gives rise to different levels of the p53 isoforms which help to orchestrate the cell biological outcome of p53 activation, [RefSeq, PubMed]; Mechanism of p53 regulation originating through alternative splicing of the human p53 gene resulting in the expression of a novel p53 mRNA, [RefSeq, PubMed]; Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17189187, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:38653238, PubMed:9840937). Negatively regulates cell division by controlling expression of a set of genes required for this process (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:9840937). One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (PubMed:12524540, PubMed:17189187). Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; P53 isoforms can regulate p53 transcriptional activity., [RefSeq, PubMed]; Recommendations and guidelines for reporting and annotating TP53 variants are also provided, to help researchers generate standardized data that are easy to understand, analyze, and exchange across various cancer variant databases Review article, [RefSeq, PubMed]; TP53 missense mutant alleles that occur in human cancers are discussed in the context of high resolution models of these p53 mutant protein structures to determine the structural features of mutations (review). Review article, [RefSeq, PubMed]; The p53 protein encoded by the 770delT allele is as abundant as the wild-type protein, as removal of the C-terminal p53 domain leads to a stabilized mutant protein, whose abundance is markedly increased when NMD is inhibited., [RefSeq, PubMed]; Therapeutic Editing of the TP53 Gene: Is CRISPR/Cas9 an Option? Review article Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 150, "reported_mutagensis": 38, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "diagnostic", "glycan_count": 1, "disease_count": 85, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q15086;Q15087;Q15088;Q16535;Q16807;Q16808;Q16809;Q16810;Q16811;Q16848;Q2XN98;Q3LRW1;Q3LRW2;Q3LRW3;Q3LRW4;Q3LRW5;Q86UG1;Q8J016;Q99659;Q9BTM4;Q9HAQ8;Q9NP68;Q9NPJ2;Q9NZD0;Q9UBI2;Q9UQ61", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0051097 negative regulation of helicase activity;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0010332 response to gamma radiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P04637-1", "record_type": "protein", "filter_code": "1000000.0100011.100000.000000000001000000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10253-1", "uniprot_id": [ { "id": "LYAG_HUMAN", "url": "https://www.uniprot.org/uniprot/P10253", "type": "external" } ], "mass": 105324.0, "length": 952, "protein_name": "Lysosomal alpha-glucosidase", "gene_name": "GAA", "organism": "Human", "refseq_name": "lysosomal alpha-glucosidase preproprotein", "refseq_ac": [ { "id": "NP_000143", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000143", "type": "external" } ], "gene_names_uniprotkb": "GAA", "gene_names_refseq": "GAA; IOPD; LOPD; LYAG", "protein_names_uniprotkb": "Lysosomal alpha-glucosidase; 3.2.1.20; Acid maltase; Aglucosidase alfa", "protein_names_refseq": "acid maltase; aglucosidase alfa; glucosidase alpha, acid; lysosomal alpha-glucosidase preproprotein; lysosomal alpha-glucosidase", "tax_id": 9606, "disease": "glycogen storage disease II (Disease Ontology:DOID:2752); glycogen storage disease due to acid maltase deficiency, late-onset (MONDO:MONDO:0018485)", "pathway": " (hsa:2548); (R-HSA-5357609); (R-HSA-6798695); (R-HSA-70221)", "pathway_count": 4, "publication_count": 177, "publication_id_list": "10.1007/s00018-021-03863-1;10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;10189220;10206684;10338092;10487978;10737124;10949035;11071489;11237011;11738358;12601120;12604216;12754519;12825073;12923862;12930917;13115432;14643388;14695532;14972326;15118078;15145338;15520017;15668445;16335952;16433701;1652892;16782080;1684505;16860134;16917947;17293352;17643989;17897319;18323634;18425781;18429042;1856189;1898413;19159218;19588081;20080426;20350966;21081667;21109266;2111708;21767668;2203258;22226559;22494547;22644586;22661428;22676651;2268276;23090970;23345538;23481700;23584533;23650620;23719902;24190977;24715725;25502872;25505266;25576301;25645385;25681614;25813380;2667896;26992070;27452731;27600516;28218747;28411811;28467828;28657654;28834231;28904123;29061980;29242379;29314611;29437277;29557506;2961257;29632711;29741879;29786170;29789417;30192525;30315122;30410026;30429286;3049072;30524438;30573663;30620550;30779550;30833945;31092671;31154438;31844290;31848261;32012848;32064362;32157095;32161166;32350084;32357974;32387766;32574038;32897882;32938616;32983136;33043033;33298915;33392160;33537174;33592498;33912179;33968037;34089345;34357683;34405274;34509645;34725712;35051231;35251023;35289036;35318648;35580925;36010968;36215666;36241641;36284347;37074911;37340703;37541260;38253038;38614290;3865697;38665916;38838015;40596516;40930100;4829444;5264799;5461220;7603530;7695647;7717400;7847371;7866409;7881422;7902568;7981676;8094613;8401535;8420990;8435067;8486380;8692836;8755644;8834250;8896567;8912788;8935410;8990003;9504428;9521422;9529346;9535769;9554747;9660056;9691087", "class_list": "glycogene;glycosylhydrolase", "function": "Data show that the mature forms of GAA characterized by polypeptides of 76 or 70 kDa are in fact larger molecular mass multicomponent enzyme complexes; peptides released during proteolytic processing remained tightly associated with the major species, [RefSeq, PubMed]; Essential for the degradation of glycogen in lysosomes (PubMed:14695532, PubMed:18429042, PubMed:1856189, PubMed:7717400). Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans (PubMed:29061980)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Human fecal alpha-glucosidase activity and its relationship with gut microbiota profiles and early stages of intestinal mucosa damage., [RefSeq, PubMed]; This gene encodes lysosomal alpha-glucosidase, which is essential for the degradation of glycogen to glucose in lysosomes. The encoded preproprotein is proteolytically processed to generate multiple intermediate forms and the mature form of the enzyme. Defects in this gene are the cause of glycogen storage disease II, also known as Pompe's disease, which is an autosomal recessive disorder with a broad clinical spectrum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 4, "mined_n_glycosites": 4, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 14, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 14, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 14, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 6, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 86, "disease_count": 2, "glyco_site_count": 23, "binding_glycan_count": 0, "secondary_ac_list": "Q09GN4;Q14351;Q16302;Q8IWE7", "ec_number_list": [ { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.78", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" } ], "go_molecular_function": "GO:0004558 alpha-1,4-glucosidase activity;GO:0030246 carbohydrate binding;GO:0090599 alpha-glucosidase activity;GO:0043896 glucan 1,6-alpha-glucosidase activity;GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0070821 tertiary granule membrane;GO:0005764 lysosome", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0007040 lysosome organization;GO:0061723 glycophagy;GO:0000023 maltose metabolic process;GO:0002086 diaphragm contraction", "synthesized_glycan_count": 0, "hit_score": 28.6, "record_id": "P10253-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000001000000.1100100001000.111.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13611-1", "uniprot_id": [ { "id": "CSPG2_HUMAN", "url": "https://www.uniprot.org/uniprot/P13611", "type": "external" } ], "mass": 372820.0, "length": 3396, "protein_name": "Versican core protein", "gene_name": "VCAN", "organism": "Human", "refseq_name": "versican core protein isoform 2 precursor", "refseq_ac": [ { "id": "NP_001119808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119808", "type": "external" } ], "gene_names_uniprotkb": "VCAN; CSPG2", "gene_names_refseq": "CSPG2; ERVR; GHAP; PG-M; VCAN; WGN1; WGN", "protein_names_uniprotkb": "Versican core protein; Chondroitin sulfate proteoglycan 2; Chondroitin sulfate proteoglycan core protein 2; GHAP; Glial hyaluronate-binding protein; Large fibroblast proteoglycan; PG-M", "protein_names_refseq": "chondroitin sulfate proteoglycan core protein 2; glial hyaluronate-binding protein; large fibroblast proteoglycan; versican core protein isoform 2 precursor; versican core protein; versican proteoglycan", "tax_id": 9606, "disease": "intracranial aneurysm (Disease Ontology:DOID:10941); myocardial infarction (Disease Ontology:DOID:5844); Wagner disease (MONDO:MONDO:0007740)", "pathway": " (hsa:1462); (R-HSA-1971475); (R-HSA-2022870); (R-HSA-2022923); (R-HSA-2024101); (R-HSA-3000178); (R-HSA-3560783); (R-HSA-3560801); (R-HSA-3595172); (R-HSA-3595174); (R-HSA-3595177); (R-HSA-381426); (R-HSA-4420332); (R-HSA-8957275)", "pathway_count": 14, "publication_count": 266, "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10022829;10026136;10077652;10187838;10218588;10339581;10339611;10397680;10473568;10506123;10512690;10614670;10673326;10681634;10781596;10781601;10810289;10842173;10898936;10912521;10951195;10963998;10990447;11056388;11084047;11099377;11139592;11158056;11237011;11250653;11259413;11264294;11316783;11414686;11470797;11514575;11522292;11551958;11568288;11606061;11739083;11751371;11788602;11788658;11877387;12080076;12145278;12163485;12225811;12241545;12379487;12466191;12512856;12522689;12556911;12761225;12810533;12874280;12888274;12904166;12907687;1370451;1376317;1383255;1429726;14715956;1478664;14993226;15075323;15126567;15211654;15215498;15294915;15296743;15308688;1544908;15461586;15469690;15485880;15525596;15642270;15647514;15980072;16043844;16293224;16493581;16505484;17047378;17194707;17227754;17249697;17312271;17588949;17985932;18316376;18491316;18513679;18698629;1907800;19188366;19224584;1928092;1946389;19473117;19655167;19661164;19664994;19824718;19889881;20004762;20301747;20533528;2059554;20691685;20830804;21129727;21129728;2122463;21269460;21642437;21763480;21789315;22134916;22739342;22810237;23090970;23481700;23584533;2364322;23656592;23664117;23664118;23704329;2412224;24190977;2420006;24275569;2430969;24425863;24443026;2466833;2469524;2476804;2479552;25326458;25502872;25521717;25576301;25813380;2583089;26091039;26154972;26375851;27599773;27600516;27862975;2820964;28411811;28657654;28832583;29391424;29514872;29557506;2971395;29741879;29777959;29786170;29789417;30237853;30429286;30459171;30779550;30833945;31154438;31217245;3134052;31844290;31848261;32157095;32337544;32350084;32387766;32488085;32502341;32938616;32983136;33091337;33123756;33592498;33631054;33968037;33981976;34130530;34211107;34450332;34509645;3468507;35051231;35251023;35580925;36010968;36213313;36241641;36284347;37074911;37938771;38665916;38719756;38842024;39333870;5822067;6193777;6439184;738706;7499434;7519608;7523391;7525263;7525634;7525824;7527058;7527330;7528742;7538844;7542669;7543116;7559467;7588299;7628016;7683646;7685013;7689487;7693733;7806529;7852349;7876137;7921538;8002934;8213840;8440685;8627343;8781553;8798654;8817670;8894645;8943283;8964575;9223416;9252349;9294172;9341124;9346959;9497324;9506957;9521684;9685393;9709957;9733769;9786878;9823490;9883891;9892646;9922210;9949188", "class_list": "glycogene", "function": "CircVCAN promotes glioma progression through the miR-488-3p/MEF2C-JAGGED1 axis., [RefSeq, PubMed]; Expression of versican isoforms V0/V1 by pancreatic cancer associated fibroblasts increases fibroblast proliferation., [RefSeq, PubMed]; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid., [UniProtKB, UniProtKB, UniProtKB]; The oncogenic ADAMTS1-VCAN-EGFR cyclic axis drives anoikis resistance and invasion in renal cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]., [RefSeq]", "predicted_glycosites": 14, "predicted_n_glycosites": 12, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 11, "reported_o_glycosites": 14, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 12, "reported_o_glycosites_with_glycan": 249, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 12, "total_reported_o_glycosites": 258, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 12, "total_o_glycosites": 258, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 1, "missing_score": 0, "biomarker_type": "", "glycan_count": 91, "disease_count": 3, "glyco_site_count": 284, "binding_glycan_count": 1, "secondary_ac_list": "P20754;Q13010;Q13189;Q15123;Q9UCL9;Q9UNW5", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0005539 glycosaminoglycan binding;GO:0008160 protein tyrosine phosphatase activator activity;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0033165 interphotoreceptor matrix;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0005796 Golgi lumen", "go_biological_process": "GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development;GO:0001649 osteoblast differentiation;GO:0008037 cell recognition", "synthesized_glycan_count": 0, "hit_score": 62.8, "record_id": "P13611-1", "record_type": "protein", "filter_code": "0000000.0001111.001000.000000000001000000.1100000011001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14410-1", "uniprot_id": [ { "id": "SUIS_HUMAN", "url": "https://www.uniprot.org/uniprot/P14410", "type": "external" } ], "mass": 209453.0, "length": 1827, "protein_name": "Sucrase-isomaltase, intestinal", "gene_name": "SI", "organism": "Human", "refseq_name": "sucrase-isomaltase, intestinal", "refseq_ac": [ { "id": "NP_001032", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032", "type": "external" } ], "gene_names_uniprotkb": "SI", "gene_names_refseq": "SI", "protein_names_uniprotkb": "Sucrase-isomaltase, intestinal", "protein_names_refseq": "Alpha-methylglucosidase; Oligo-1,6-glucosidase; alpha-glucosidase; oligosaccharide alpha-1,6-glucosidase; sucrase-isomaltase, intestinal", "tax_id": 9606, "disease": "colitis (Disease Ontology:DOID:0060180); congenital sucrase-isomaltase deficiency (Disease Ontology:DOID:0111633); exocrine pancreatic insufficiency (Disease Ontology:DOID:13316)", "pathway": " (hsa:6476); (R-HSA-189085); (R-HSA-5659898)", "pathway_count": 3, "publication_count": 64, "publication_id_list": "10769135;10903344;11085997;11237011;11340066;12547908;1256470;12692040;1353958;14616060;14724820;15299664;16329100;16400612;16584180;1677636;1697585;18824549;19121318;19161632;19241384;19435888;19955176;20356844;2452973;27862975;28522605;29242379;29557506;2962903;29758065;29789417;31154438;31254546;31844290;31848261;3227291;32387766;3366777;33968037;34242650;35051231;35494241;35580925;36878682;37074911;37217939;37349966;3800897;3897250;39128102;4737205;5104075;5849827;6466686;7487100;7836450;7906143;807575;8521865;8609217;8951031;9427547;9446624", "class_list": "glycogene;glycosylhydrolase", "function": "Bifunctional enzyme with both sucrase and isomaltase activities involved in breakdown of dietary starch oligosaccharides in small intestine. The isomaltase domain hydrolazes alpha-1,6-glycosidic linkages in isomaltose. The sucrase domain cleaves the alpha-1,2-glycosidic linkages in sucrose to form glucose and fructose, and contributes to the cleavage of the alpha-1,4-glycosidic linkage in maltose to form two glucose monosaccharides., [UniProtKB, PubMed, PubMed]; Congenital Sucrase-Isomaltase Deficiency: Same Mutation with Different Clinical Presentations., [RefSeq, PubMed]; Prevalence of congenital sucrase-isomaltase deficiency in Turkey may be much higher than the estimates., [RefSeq, PubMed]; Sucrase-isomaltase genotype and response to a starch-reduced and sucrose-reduced diet in IBS-D patients. Publication Status: Online-Only, [RefSeq, PubMed]; The glucose-regulated protein GRP94 interacts avidly in the endoplasmic reticulum with sucrase-isomaltase isoforms that are associated with congenital sucrase-isomaltase deficiency., [RefSeq, PubMed]; This gene encodes a sucrase-isomaltase enzyme that is expressed in the intestinal brush border. The encoded protein is synthesized as a precursor protein that is cleaved by pancreatic proteases into two enzymatic subunits sucrase and isomaltase. These two subunits heterodimerize to form the sucrose-isomaltase complex. This complex is essential for the digestion of dietary carbohydrates including starch, sucrose and isomaltose. Mutations in this gene are the cause of congenital sucrase-isomaltase deficiency.[provided by RefSeq, Apr 2010]., [RefSeq]", "predicted_glycosites": 17, "predicted_n_glycosites": 13, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 3, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 3, "glyco_site_count": 22, "binding_glycan_count": 0, "secondary_ac_list": "A2RUC3;Q1JQ80;Q1RMC2", "ec_number_list": [ { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "3.2.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.10", "type": "external" }, { "id": "3.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.48", "type": "external" } ], "go_molecular_function": "GO:0004558 alpha-1,4-glucosidase activity;GO:0030246 carbohydrate binding;GO:0004574 oligo-1,6-glucosidase activity;GO:0004575 sucrose alpha-glucosidase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0070062 extracellular exosome;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0044245 polysaccharide digestion;GO:0005987 sucrose catabolic process", "synthesized_glycan_count": 0, "hit_score": 7.6, "record_id": "P14410-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000001000000.1100000011001.101.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16112-1", "uniprot_id": [ { "id": "PGCA_HUMAN", "url": "https://www.uniprot.org/uniprot/P16112", "type": "external" } ], "mass": 261329.0, "length": 2530, "protein_name": "Aggrecan core protein", "gene_name": "ACAN", "organism": "Human", "refseq_name": "aggrecan core protein isoform 2 precursor", "refseq_ac": [ { "id": "NP_037359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037359", "type": "external" } ], "gene_names_uniprotkb": "ACAN; AGC1; CSPG1; MSK16", "gene_names_refseq": "ACAN; AGC1; AGCAN; CSPG1; CSPGCP; MSK16; SEDK; SSOAOD", "protein_names_uniprotkb": "Aggrecan core protein; CSPCP; Cartilage-specific proteoglycan core protein; Chondroitin sulfate proteoglycan 1; Chondroitin sulfate proteoglycan core protein 1", "protein_names_refseq": "aggrecan core protein isoform 2 precursor; aggrecan core protein; cartilage-specific proteoglycan core protein; chondroitin sulfate proteoglycan core protein 1; large aggregating proteoglycan", "tax_id": 9606, "disease": "stroke (Disease Ontology:DOID:0051061); spondyloepiphyseal dysplasia Kimberley type (Disease Ontology:DOID:0112282); status epilepticus (Disease Ontology:DOID:1824); multiple sclerosis (Disease Ontology:DOID:2377); achondroplasia (Disease Ontology:DOID:4480); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398); osteochondritis dissecans (Disease Ontology:DOID:84); degenerative disc disease (Disease Ontology:DOID:90); spondyloepimetaphyseal dysplasia, aggrecan type (MONDO:MONDO:0013014)", "pathway": " (hsa:176); (R-HSA-1474228); (R-HSA-2022854); (R-HSA-2022857); (R-HSA-3000178); (R-HSA-3656225); (R-HSA-3656243); (R-HSA-3656244)", "pathway_count": 8, "publication_count": 194, "publication_id_list": "10.1101/2023.09.13.557529;10022829;10206952;10229672;10339611;10386589;10491328;10504389;10673326;10706100;10809722;10986281;11017086;11030741;11042166;11042394;11084047;11237011;11259413;11283017;11375993;11588157;11821425;11872628;11901181;12218059;12225811;12727852;12843408;12888274;1326552;1376317;14216462;1463457;14715956;14973287;15013869;15075323;1522213;15234972;15296743;1544908;15486459;15489334;15560372;15591058;15620693;15647514;1569188;15958533;16080123;16133547;16293224;16335952;16493581;1649600;16572171;16631740;16825321;1698775;17021253;1707285;17120046;1714903;17332331;17354228;17588949;17608959;1794986;18434311;18658137;19010778;1907800;19110214;1928092;19571574;19657146;19714641;1985970;20137779;20142769;20232353;2059554;21030783;21297635;21441952;21642437;21670566;21784848;21789315;21864727;21907012;22134916;22159414;22940367;23035980;23090970;23252400;2364322;23845380;2412224;24190977;2420006;2430969;24762113;25645385;25741789;27710243;27870580;2789216;28331218;28583308;29351928;29557506;29671580;2971395;29731959;29789417;30124491;30237853;30315122;30459171;31844290;3196333;32157095;32337544;32387766;32983136;33392160;33471655;33592498;33606014;33990642;34051020;34063326;34625928;35051231;35338222;35494241;36010968;36213313;36597844;36972946;37074911;37227215;37938771;38034954;38253038;38613222;40930100;41178200;5822067;6193777;6439184;7075587;7213753;7240256;7499434;7524681;7527058;7542669;7547873;7559467;7574678;7685013;7693733;7827755;7852349;8002934;8216415;8226919;8333853;8440685;8611178;8611500;8626565;8798654;8920913;8943283;9065415;9115292;9148753;9252349;9294172;9341124;9346959;9405439;9417100;9461298;9521684;9597550;9685393;9852107;9949188", "class_list": "glycogene", "function": "Brachyury positively regulates extracellular matrix synthesis via directly promoting aggrecan transcription in nucleus pulposus., [RefSeq, PubMed]; Downregulation of ACAN is Associated with the Growth hormone pathway and Induces short stature., [RefSeq, PubMed]; Genotype and phenotype in patients with ACAN gene variants: Three cases and literature review. Review article, [RefSeq, PubMed]; Novel missense ACAN gene variants linked to familial osteochondritis dissecans cluster in the C-terminal globular domain of aggrecan. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region., [UniProtKB]; [Analysis of a Chinese pedigree affected with familial short stature due to 15q25.3q26.1 deletion involving the ACAN gene]., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 4, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 8, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 74, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 77, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 77, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 47, "disease_count": 11, "glyco_site_count": 90, "binding_glycan_count": 0, "secondary_ac_list": "B9EK55;E7ENV9;E7EX88;H0YM81;H0YMF1;Q13650;Q9UCD3;Q9UCP4;Q9UCP5;Q9UDE0", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0005201 extracellular matrix structural constituent;GO:0005540 hyaluronic acid binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005796 Golgi lumen;GO:0031012 extracellular matrix;GO:0045202 synapse", "go_biological_process": "GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 32.4, "record_id": "P16112-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000001000000.1100000011001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22105-3", "uniprot_id": [ { "id": "TENX_HUMAN", "url": "https://www.uniprot.org/uniprot/P22105", "type": "external" } ], "mass": 458388.0, "length": 4244, "protein_name": "Tenascin-X", "gene_name": "TNXB", "organism": "Human", "refseq_name": "tenascin-X isoform 1 precursor", "refseq_ac": [ { "id": "NP_061978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061978", "type": "external" } ], "gene_names_uniprotkb": "TNXB; HXBL; TNXB1; TNXB2; TNX; XB", "gene_names_refseq": "EDS3; EDSCLL1; EDSCLL; HXBL; TENX; TN-X; TNXB1; TNXB2; TNXBS; TNXB; TNX; VUR8; XBS; XB", "protein_names_uniprotkb": "Tenascin-X; Hexabrachion-like protein; TN-X", "protein_names_refseq": "growth-inhibiting protein 45; hexabrachion-like protein; tenascin XB1; tenascin XB2; tenascin-X isoform 1 precursor; tenascin-X", "tax_id": 9606, "disease": "Ehlers-Danlos syndrome classic-like 1 (Disease Ontology:DOID:0080731); alcoholic cardiomyopathy (Disease Ontology:DOID:12935); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); vesicoureteral reflux (Disease Ontology:DOID:9620)", "pathway": " (hsa:7148); (R-HSA-3000178)", "pathway_count": 2, "publication_count": 88, "publication_id_list": "10.1038/emboj.2013.79;10022829;10339611;10673326;11084047;11259413;11278641;11642233;12225811;12865992;1373119;1376317;14656967;14715956;15075323;15296743;1544908;15733269;16293224;16335952;16493581;17033827;17263730;17588949;2059554;21642437;21789315;22134916;23584533;23620400;2364322;23768946;2412224;2420006;2430969;2475872;27543614;27726376;27862975;28411811;28657654;28832583;29242379;29391424;29557506;29789417;30459171;30524438;31844290;32387766;32938616;33592498;33968037;34087483;34171305;34509645;34932366;35051231;35580925;36259452;37074911;37209968;37217939;38253038;38819423;6193777;6439184;7499434;7512972;7527058;7542669;7559467;7685013;7686164;7693733;7852349;8002934;8440685;8530023;8798654;8923003;8943283;9252349;9294172;9341124;9346959;9685393;9949188", "class_list": "glycogene", "function": "Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors., [UniProtKB, PubMed]; Congenital adrenal hyperplasia with a CYP21A2 deletion overlapping the tenascin-X gene: an atypical presentation. Publication Status: Online-Only, [RefSeq, PubMed]; Tenascins and osteopontin in biological response in cornea., [RefSeq, PubMed]; This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 12, "predicted_n_glycosites": 3, "predicted_o_glycosites": 9, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 3, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 39, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 39, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 39, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 27, "disease_count": 4, "glyco_site_count": 53, "binding_glycan_count": 0, "secondary_ac_list": "P78530;P78531;Q08424;Q08AM0;Q08AM1;Q59GU7;Q5SQD3;Q5ST74;Q7L8Q4;Q8N4R1;Q9NPK9;Q9UC10;Q9UC11;Q9UC12;Q9UC13;Q9UMG7", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0005518 collagen binding;GO:0005201 extracellular matrix structural constituent;GO:0098633 collagen fibril binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0070062 extracellular exosome", "go_biological_process": "GO:0007155 cell adhesion;GO:0030155 regulation of cell adhesion;GO:0031175 neuron projection development;GO:0030036 actin cytoskeleton organization;GO:0045595 regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 15.7, "record_id": "P22105-3", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000001000000.1100000011000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23471-1", "uniprot_id": [ { "id": "PTPRZ_HUMAN", "url": "https://www.uniprot.org/uniprot/P23471", "type": "external" } ], "mass": 254587.0, "length": 2315, "protein_name": "Receptor-type tyrosine-protein phosphatase zeta", "gene_name": "PTPRZ1", "organism": "Human", "refseq_name": "receptor-type tyrosine-protein phosphatase zeta isoform 2 precursor", "refseq_ac": [ { "id": "NP_001193767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193767", "type": "external" } ], "gene_names_uniprotkb": "PTPRZ1; HTPZP2; PTPRZ2; PTPRZ; PTPZ", "gene_names_refseq": "HPTPZ; HPTPzeta; PTP-ZETA; PTP18; PTPRZ1; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta; phosphacan", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase zeta; 3.1.3.48; Protein-tyrosine phosphatase receptor type Z polypeptide 1; Protein-tyrosine phosphatase receptor type Z polypeptide 2; R-PTP-zeta-2; R-PTP-zeta", "protein_names_refseq": "protein tyrosine phosphatase, receptor-type, Z polypeptide 1; protein tyrosine phosphatase, receptor-type, zeta polypeptide 1; protein-tyrosine phosphatase receptor type Z polypeptide 2; receptor-type tyrosine phosphatase beta/zeta; receptor-type tyrosine-protein phosphatase zeta isoform 2 precursor", "tax_id": 9606, "disease": "status epilepticus (Disease Ontology:DOID:1824); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); gastric adenocarcinoma (Disease Ontology:DOID:3717)", "pathway": " (hsa:5803); (R-HSA-449836); (R-HSA-9851151)", "pathway_count": 3, "publication_count": 77, "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10212223;10395686;10438516;11237011;11278720;12107166;12122009;12469119;12558796;1323835;16317043;16335952;16488976;16492764;16814777;17681947;18452278;18467591;20133774;21406692;2147944;2169617;2170109;21716315;23090970;23201355;23291588;23584533;23744080;23777859;24190977;24714562;25645385;25662098;25892735;26095744;26896299;26992070;27424145;27445335;27600516;28228285;28657654;29308320;29393594;29455642;29557506;29671580;29789417;30429286;30568303;31217245;31844290;32157095;32488085;32897882;32938616;34087483;35051231;35457233;35580925;35883571;36228153;36241641;36284347;37543361;37938771;38253038;38685521;7559574;7615501;7805849;8387522;9422780;9653645", "class_list": "glycogene", "function": "Brain-specific glycosylation enzyme GnT-IX maintains levels of protein tyrosine phosphatase receptor PTPRZ, thereby mediating glioma growth., [RefSeq, PubMed]; Protein Tyrosine Phosphatase Receptor Type Z in Central Nervous System Disease. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The Glycoprotein M6a Is Associated with Invasiveness and Radioresistance of Glioblastoma Stem Cells. Publication Status: Online-Only, [RefSeq, PubMed]; The PTPRZ1-MET/STAT3/ISG20 axis in glioma stem-like cells modulates tumor-associated macrophage polarization., [RefSeq, PubMed]; This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]., [RefSeq]", "predicted_glycosites": 19, "predicted_n_glycosites": 13, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 20, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 20, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 20, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 5, "glyco_site_count": 45, "binding_glycan_count": 0, "secondary_ac_list": "A4D0W5;C9JFM0;O76043;Q9UDR6", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" } ], "go_molecular_function": "GO:0005178 integrin binding;GO:0005001 transmembrane receptor protein tyrosine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0072534 perineuronal net", "go_biological_process": "GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0007165 signal transduction;GO:0007611 learning or memory;GO:0031175 neuron projection development;GO:0048714 positive regulation of oligodendrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 11.1, "record_id": "P23471-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000001000000.1100100011001.111.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35573-1", "uniprot_id": [ { "id": "GDE_HUMAN", "url": "https://www.uniprot.org/uniprot/P35573", "type": "external" } ], "mass": 174764.0, "length": 1532, "protein_name": "Glycogen debranching enzyme", "gene_name": "AGL", "organism": "Human", "refseq_name": "glycogen debranching enzyme isoform 1", "refseq_ac": [ { "id": "NP_000019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000019", "type": "external" } ], "gene_names_uniprotkb": "AGL; GDE", "gene_names_refseq": "AGL; GDE", "protein_names_uniprotkb": "Glycogen debranching enzyme; Dextrin 6-alpha-D-glucosidase; Glycogen debrancher; Oligo-1,4-1,4-glucantransferase", "protein_names_refseq": "amylo-1, 6-glucosidase, 4-alpha-glucanotransferase; amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferaseprovided; glycogen debrancher; glycogen debranching enzyme isoform 1; glycogen debranching enzyme; glycogen debranching protein", "tax_id": 9606, "disease": "glycogen storage disease III (Disease Ontology:DOID:2748); uremia (Disease Ontology:DOID:4676); congenital disorder of glycosylation (Disease Ontology:DOID:5212)", "pathway": " (hsa:178); (R-HSA-6798695); (R-HSA-70221)", "pathway_count": 3, "publication_count": 102, "publication_id_list": "10487978;10571954;10655153;10925384;10949035;10982190;11237011;11378828;12604216;12825073;12930917;13115432;1374391;15118078;17547437;17908927;18083107;18323634;19299494;19834502;21767668;23481700;23650620;24275569;24714562;24715725;25418920;25576301;25645385;25892735;26154972;2667896;26811146;26975021;26984562;26992070;27846572;28510447;28904123;29437277;29493099;29557506;2961257;29794575;30379171;30397120;30410026;30429286;3049072;31020640;31028654;31844290;32157095;32222031;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;33141586;33298915;33537174;33592498;33691108;33717175;33912179;33936100;33968037;34019948;34171305;34185709;34211107;34357683;34509645;34725712;34932366;35051231;35561310;35580925;36010968;36215666;36241641;36581221;37938771;4829444;5264799;5461220;7847371;7902568;8420990;8692836;8755644;8896567;8954797;8990006;9332391;9412782;9504428;9691087", "class_list": "glycogene;glycosylhydrolase;glycosyltransferase", "function": "AGL loss causes high SHMT2 expression and consequently increases glycine-dependent nucleotide synthesis leading to bladder cancer growth. Review article, [RefSeq, PubMed]; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation., [UniProtKB]; Six novel mutations were identified in GSD III patients., [RefSeq, PubMed]; Spectrum of amyloglucosidase mutations in Asian Indian patients with Glycogen storage disease type III., [RefSeq, PubMed]; The study identified 31 novel mutations and extended the mutation spectrum of AGL in Chinese patients with glycogen storage disease type III., [RefSeq, PubMed]; This gene encodes the glycogen debrancher enzyme which is involved in glycogen degradation. This enzyme has two independent catalytic activities which occur at different sites on the protein: a 4-alpha-glucotransferase activity and a amylo-1,6-glucosidase activity. Mutations in this gene are associated with glycogen storage disease although a wide range of enzymatic and clinical variability occurs which may be due to tissue-specific alternative splicing. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]., [RefSeq]; This report of patients with GSD-III in Iran with 2 uncommon clinical presentations and 5 novel mutations in the AGL gene., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6NCX7;A6NEK2;D3DT51;P78354;P78544;Q59H92;Q6AZ90;Q9UF08", "ec_number_list": [], "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0004134 4-alpha-glucanotransferase activity;GO:0004135 amylo-alpha-1,6-glucosidase activity;GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0043033 isoamylase complex;GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007584 response to nutrient;GO:0051384 response to glucocorticoid;GO:0005978 glycogen biosynthetic process;GO:0005980 glycogen catabolic process", "synthesized_glycan_count": 0, "hit_score": 10.6, "record_id": "P35573-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000001000000.0100000000001.000.11100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98160-1", "uniprot_id": [ { "id": "PGBM_HUMAN", "url": "https://www.uniprot.org/uniprot/P98160", "type": "external" } ], "mass": 468830.0, "length": 4391, "protein_name": "Basement membrane-specific heparan sulfate proteoglycan core protein", "gene_name": "HSPG2", "organism": "Human", "refseq_name": "basement membrane-specific heparan sulfate proteoglycan core protein isoform a precursor", "refseq_ac": [ { "id": "NP_001278789", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278789", "type": "external" } ], "gene_names_uniprotkb": "HSPG2", "gene_names_refseq": "HSPG2; HSPG; PLC; PRCAN; SJA; SJS1; SJS", "protein_names_uniprotkb": "Basement membrane-specific heparan sulfate proteoglycan core protein; HSPG; PLC; Perlecan", "protein_names_refseq": "basement membrane-specific heparan sulfate proteoglycan core protein isoform a precursor; basement membrane-specific heparan sulfate proteoglycan core protein; endorepellin (domain V region); perlecan proteoglycan", "tax_id": 9606, "disease": "dextro-looped transposition of the great arteries (Disease Ontology:DOID:0060770); Schwartz-Jampel syndrome 1 (Disease Ontology:DOID:0090005); Silverman-Handmaker type dyssegmental dysplasia (Disease Ontology:DOID:0090032); hypertension (Disease Ontology:DOID:10763); thanatophoric dysplasia (Disease Ontology:DOID:13481); osteochondrodysplasia (Disease Ontology:DOID:2256); carotid artery disease (Disease Ontology:DOID:3407); hyperglycemia (Disease Ontology:DOID:4195)", "pathway": " (hsa:3339); (R-HSA-1474228); (R-HSA-1971475); (R-HSA-2022928); (R-HSA-2024096); (R-HSA-216083); (R-HSA-3000157); (R-HSA-3000171); (R-HSA-3000178); (R-HSA-3560783); (R-HSA-3560801); (R-HSA-3656237); (R-HSA-3656253); (R-HSA-4420332); (R-HSA-9694614); (R-HSA-975634); (R-HSA-9769735); (R-HSA-9769739); (R-HSA-977225); (R-HSA-9820960); (R-HSA-9833110); (R-HSA-9856532); (R-HSA-9913351); (R-HSA-9918481); (R-HSA-9918485)", "pathway_count": 25, "publication_count": 635, "publication_id_list": 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"class_list": "glycogene", "function": "Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6., [UniProtKB]; Dyssegmental dysplasia Rolland-Desbuquois type is caused by pathogenic variants in HSPG2 - a founder haplotype shared in five patients., [RefSeq, PubMed]; Has anti-angiogenic properties that require binding of calcium ions for full activity., [UniProtKB]; Identification of B-cell-related HSPG2 and CDSN as susceptibility loci for Kawasaki disease., [RefSeq, PubMed]; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development (PubMed:12435733, PubMed:15591058, PubMed:19789387). In muscle, it is essential for localizing acetylcholinesterase (AChE) at the neuromuscular junctions (NMJ), most probably acting as an adapter that links the acetylcholinesterase collagenic tail peptide (COLQ) to alpha-dystroglycan, and is therefore involved in the down-regulation of colinergic synaptic transmission (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes., [RefSeq, PubMed]; Perlecan: Roles in osteoarthritis and potential treating target. Review article, [RefSeq, PubMed]; This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and transthyretin, etc., and it plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and tardive dyskinesia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]., [RefSeq]", "predicted_glycosites": 8, "predicted_n_glycosites": 2, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 9, "reported_o_glycosites": 4, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 71, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 9, "total_reported_o_glycosites": 73, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 9, "total_o_glycosites": 73, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 184, "disease_count": 8, "glyco_site_count": 90, "binding_glycan_count": 0, "secondary_ac_list": "Q16287;Q5SZI3;Q9H3V5", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0050750 low-density lipoprotein particle receptor binding;GO:0001540 amyloid-beta binding;GO:0005509 calcium ion binding;GO:0030021 extracellular matrix structural constituent conferring compression resistance", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005796 Golgi lumen;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "GO:0072359 circulatory system development;GO:0001525 angiogenesis;GO:0006629 lipid metabolic process;GO:0006954 inflammatory response;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 90.2, "record_id": "P98160-1", "record_type": "protein", "filter_code": "0000000.0100111.001000.000000000001000000.1100000011001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98161-1", "uniprot_id": [ { "id": "PKD1_HUMAN", "url": "https://www.uniprot.org/uniprot/P98161", "type": "external" } ], "mass": 462529.0, "length": 4303, "protein_name": "Polycystin-1", "gene_name": "PKD1", "organism": "Human", "refseq_name": "polycystin-1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001009944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009944", "type": "external" } ], "gene_names_uniprotkb": "PKD1", "gene_names_refseq": "PBP; PC1; PKD1; Pc-1; TRPP1; eliosin", "protein_names_uniprotkb": "Polycystin-1; Autosomal dominant polycystic kidney disease 1 protein; PC1", "protein_names_refseq": "autosomal dominant polycystic kidney disease 1 protein; polycystic kidney disease 1 (autosomal dominant); polycystic kidney disease-associated protein; polycystin-1 isoform 1 precursor; polycystin-1; transient receptor potential cation channel, subfamily P, member 1", "tax_id": 9606, "disease": "polycystic liver disease (Disease Ontology:DOID:0050770); polycystic kidney disease (Disease Ontology:DOID:0080322); polycystic kidney disease 1 (Disease Ontology:DOID:0110858); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); intracranial aneurysm (Disease Ontology:DOID:10941); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (hsa:5310); (R-HSA-5620916)", "pathway_count": 2, "publication_count": 162, "publication_id_list": "10.1101/2023.09.13.557529;10200984;10339594;10362514;10364515;10577909;10647901;10729710;10854095;10923040;10987650;11012875;11058904;11115377;11216660;11237011;11316854;11558899;11571556;11691639;11698076;11773467;11857740;11967008;12007219;12070253;12220456;12221131;12482949;12842373;15158452;15728366;15772804;16038802;16136078;16155582;16431365;16537653;16651260;16782012;17007872;17030804;17081983;17525154;17574030;17628206;17646400;17956946;17980165;18685082;18837007;19017632;19153612;19297529;19454479;19615748;20083215;20166139;20308558;20444281;20856870;20881056;20980620;21115670;21126580;21273506;21550243;21565611;21775626;21998636;22389062;22420621;22424782;22433857;22508176;22983554;23028574;23129748;23351793;23481700;23567335;23945166;24153433;24296415;24366607;24715725;24740233;24939912;25517939;25645385;25892735;26154972;26992070;27214281;27259053;27600516;27862975;27920218;28218747;28228285;28228588;28411811;28832583;28834231;28904123;29242379;29393594;29437277;29557506;29769354;29786170;30101477;30315122;30410026;30419840;30429286;30524438;31217245;31591827;31844290;32157095;32350084;32357974;32387766;32502341;32938616;32983136;33141586;33298915;33392160;33592498;33912179;33968037;34087483;34171305;34357683;34509645;35051231;35580925;36010968;36241641;37074911;37681898;38194940;38527221;38552045;41166294;7581371;7663510;8554072;8792818;8845849;9150733;9199561;9259200;9285784;9345095;9521593;9668165;9819391;9889186;9921908", "class_list": "glycogene", "function": "A de novo PKD1 mutation in a Chinese family with autosomal dominant polycystic kidney disease., [RefSeq, PubMed]; Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281). Both PKD1 and PKD2 are required for channel activity (PubMed:27214281). Involved in renal tubulogenesis (PubMed:12482949). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity). The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions. Likely to be involved with polycystin-1-interacting protein 1 in the detection, sequestration and exocytosis of senescent mitochondria (PubMed:37681898)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Comprehensive Analysis of PKD1 and PKD2 by Long-Read Sequencing in Autosomal Dominant Polycystic Kidney Disease., [RefSeq, PubMed]; PKD1 Truncating Mutations Accelerate eGFR Decline in Autosomal Dominant Polycystic Kidney Disease Patients., [RefSeq, PubMed]; Plays a role in mitochondrial dynamics. In immortalized renal cyst cells, converts fragmented mitochondria to a filamentous shape., [UniProtKB, PubMed]; This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described. [provided by RefSeq, Oct 2008]., [RefSeq]", "predicted_glycosites": 48, "predicted_n_glycosites": 42, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 18, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 18, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 18, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 18, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 7, "glyco_site_count": 66, "binding_glycan_count": 0, "secondary_ac_list": "Q15140;Q15141", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0044325 transmembrane transporter binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0034703 cation channel complex;GO:0002133 polycystin complex;GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0048806 genitalia development;GO:0007161 calcium-independent cell-matrix adhesion;GO:0072164 mesonephric tubule development;GO:0072218 metanephric ascending thin limb development;GO:0072237 metanephric proximal tubule development", "synthesized_glycan_count": 0, "hit_score": 19.0, "record_id": "P98161-1", "record_type": "protein", "filter_code": 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"glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A1P8B7J0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.100000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1P8B7J5-1", "uniprot_id": [ { "id": "A0A1P8B7J5_ARATH", "url": "https://www.uniprot.org/uniprot/A0A1P8B7J5", "type": "external" } ], "mass": 7925.0, "length": 67, "protein_name": "Uncharacterized protein", "gene_name": "", "organism": "Arabidopsis", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_001329388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001329388", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": 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"reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A1P8B7J5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.100000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O48726-1", "uniprot_id": [ { "id": "RPN13_ARATH", "url": "https://www.uniprot.org/uniprot/O48726", "type": "external" } ], "mass": 33297.0, "length": 300, "protein_name": "26S proteasome regulatory subunit RPN13", "gene_name": "RPN13", "organism": "Arabidopsis", "refseq_name": "regulatory particle non-ATPase 13", "refseq_ac": [ { "id": "NP_001031424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001031424", "type": "external" } ], "gene_names_uniprotkb": "RPN13; T9J22.26; T9J22_26", "gene_names_refseq": "RPN13; T9J22.26; T9J22_26; regulatory particle non-ATPase 13", "protein_names_uniprotkb": "26S proteasome regulatory subunit RPN13; 26S proteasome non-ATPase regulatory subunit 13; AtRPN13", "protein_names_refseq": "regulatory particle non-ATPase 13", "tax_id": 3702, "disease": "", "pathway": " (ath:AT2G26590)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10617197;14593172;20059542;20399133;21764993;22751321;23111157;27862469", "class_list": "", "function": "Functions as a proteasomal ubiquitin receptor. Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-63'-linked ubiquitin chains., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q94JW3", "ec_number_list": [], "go_molecular_function": "GO:0061133 endopeptidase activator activity;GO:0070628 proteasome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0008541 proteasome regulatory particle, lid subcomplex;GO:0000502 proteasome complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O48726-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.100000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O48782-1", "uniprot_id": [ { "id": "HMOX1_ARATH", "url": "https://www.uniprot.org/uniprot/O48782", "type": "external" } ], "mass": 32691.0, "length": 282, "protein_name": "Heme oxygenase 1, chloroplastic", "gene_name": "HO1", "organism": "Arabidopsis", "refseq_name": "Plant heme oxygenase (decyclizing) family protein", "refseq_ac": [ { "id": "NP_001118392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001118392", "type": "external" } ], "gene_names_uniprotkb": "HO1; F18A8.4; GUN2; HY1; HY6; TED4", "gene_names_refseq": "ARABIDOPSIS THALIANA HEME OXYGENASE 1; ATHO1; F18A8.4; F18A8_4; GENOMES UNCOUPLED 2; GUN2; HEME OXYGENASE 1; HEME OXYGENASE 6; HEME OXYGENASE; HO1; HY1; HY6; PLASTID HEME OXYGENASE; REVERSAL OF THE DET PHENOTYPE 4; TED4", "protein_names_uniprotkb": "Heme oxygenase 1, chloroplastic; 1.14.14.18; AtHO1; Protein GENOMES UNCOUPLED 2; Protein REVERSAL OF THE DET PHENOTYPE 4", "protein_names_refseq": "Plant heme oxygenase (decyclizing) family protein", "tax_id": 3702, "disease": "", "pathway": " (ath:AT2G26670)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10072395;10339624;10617197;11135121;11172074;12232145;12324588;12359912;12481078;14593172;16428602;17567636;19860740;20979354;21205037;23111157;27862469;7690685", "class_list": "", "function": "Key enzyme in the synthesis of the chromophore of the phytochrome family of plant photoreceptors. Catalyzes the opening of the heme ring to form the open-chain tetrapyrrole biliverdin IX with the release of iron and carbon monoxide (CO). Produces specifically the biliverdin IX-alpha isomer. Can form complex with heme, is ferredoxin-dependent and its activity is increased in the presence of ascorbate. Plays a role in salt acclimation signaling. May affect the plastid-to-nucleus signaling pathway by perturbing tetrapyrrole synthesis. The plastid-to-nucleus signal plays an important role in the coordinated expression of both nuclear- and chloroplast-localized genes that encode photosynthesis-related proteins., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3H4A6;Q7E9A5;Q9FPE3", "ec_number_list": [ { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004392 heme oxygenase (decyclizing) activity", "go_cellular_component": "GO:0009507 chloroplast", "go_biological_process": "GO:0071494 cellular response to UV-C;GO:0006788 heme oxidation;GO:0009813 flavonoid biosynthetic process;GO:0010019 chloroplast-nucleus signaling pathway;GO:0010024 phytochromobilin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "O48782-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.100000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9SII8-1", "uniprot_id": [ { "id": "DSK2B_ARATH", "url": "https://www.uniprot.org/uniprot/Q9SII8", "type": "external" } ], "mass": 58054.0, "length": 551, "protein_name": "Ubiquitin domain-containing protein DSK2b", "gene_name": "DSK2B", "organism": "Arabidopsis", "refseq_name": "ubiquitin family protein", "refseq_ac": [ { "id": "NP_179311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_179311", "type": "external" } ], "gene_names_uniprotkb": "DSK2B; T23A1.6", "gene_names_refseq": "DSK2b; DSK2; T23A1.6; T23A1_6", "protein_names_uniprotkb": "Ubiquitin domain-containing protein DSK2b", "protein_names_refseq": "ubiquitin family protein", "tax_id": 3702, "disease": "", "pathway": " (ath:AT2G17200)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10617197;14593172;20399133;21764993;23336935;27862469", "class_list": "", "function": "Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q94C51", "ec_number_list": [], "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9SII8-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.100000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9M4A2-1", "uniprot_id": [ { "id": "SPO11_ARATH", "url": "https://www.uniprot.org/uniprot/Q9M4A2", "type": "external" } ], "mass": 41804.0, "length": 362, "protein_name": "Meiotic recombination protein SPO11-1", "gene_name": "SPO11-1", "organism": "Arabidopsis", "refseq_name": "Spo11/DNA topoisomerase VI, subunit A protein", "refseq_ac": [ { "id": "NP_187923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_187923", "type": "external" } ], "gene_names_uniprotkb": "SPO11-1; ATSPO11-1; MJG19.19", "gene_names_refseq": "ATSPO11-1; SPO11-1", "protein_names_uniprotkb": "Meiotic recombination protein SPO11-1; 5.6.2.2; AtSPO11-1", "protein_names_refseq": "Spo11/DNA topoisomerase VI, subunit A protein", "tax_id": 3702, "disease": "", "pathway": " (ath:AT3G13170)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10710421;10907853;11130713;11157765;11410368;17018031;17762870;17785529;17965269;19763177;26917763;27862469;28855712", "class_list": "", "function": "DNA endonuclease, which specifically mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (PubMed:11157765, PubMed:17018031, PubMed:17965269, PubMed:19763177, PubMed:26917763). SPO11 covalently attaches itself to the 5' DNA strand during DSB formation and each strand is cleaved by a composite active site assembled at the interface of two SPO11 monomers, with the two cleavages staggered to produce a two-nucleotide 5' overhang (By similarity). SPO11 cleavage site selection is driven by a mild sequence bias and a preference for bendable and underwound DNA (PubMed:11157765, PubMed:17018031, PubMed:17965269, PubMed:26917763)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9C5S3;Q9LK56", "ec_number_list": [], "go_molecular_function": "GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000228 nuclear chromosome;GO:0005694 chromosome", "go_biological_process": "GO:0000724 double-strand break repair via homologous recombination;GO:0007129 homologous chromosome pairing at meiosis;GO:0042138 meiotic DNA double-strand break formation;GO:0000706 meiotic DNA double-strand break processing;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9M4A2-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.100000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9M9P3-1", "uniprot_id": [ { "id": "UGPA2_ARATH", "url": "https://www.uniprot.org/uniprot/Q9M9P3", "type": "external" } ], "mass": 51738.0, "length": 469, "protein_name": "UTP--glucose-1-phosphate uridylyltransferase 2", "gene_name": "UGP1; UGP2", "organism": "Arabidopsis", "refseq_name": "UDP-GLUCOSE PYROPHOSPHORYLASE 1", "refseq_ac": [ { "id": "NP_186975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_186975", "type": "external" } ], "gene_names_uniprotkb": "UGP1; UGP2; AtUGP1; T17B22.6; T17B22_6; UDP-glucose pyrophosphorylase; UGPASE; UGP", "gene_names_refseq": "AtUGP1; T17B22.6; T17B22_6; UDP-GLUCOSE PYROPHOSPHORYLASE 1; UDP-glucose pyrophosphorylase; UGP1; UGPASE; UGP", "protein_names_uniprotkb": "UTP--glucose-1-phosphate uridylyltransferase 2; 2.7.7.9; AtUGP2; UDP-glucose pyrophosphorylase 2; UDPGP 2; UGPase 2", "protein_names_refseq": "UDP-GLUCOSE PYROPHOSPHORYLASE 1", "tax_id": 3702, "disease": "", "pathway": " (ath:AT3G03250)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11130713;14593172;17178129;17272265;18463617;19366709;20435647;20466843;22223895;22631563;23111157;23572148;25561503;26091701;27862469", "class_list": "", "function": "Converts glucose 1-phosphate to UDP-glucose, which is the major glycosyl donor for polysaccharides. Acts redundantly with UGP1 and is essential for the synthesis of sucrose, starch and cell wall, and callose deposition., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ASY1", "ec_number_list": [ { "id": "2.7.7.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.9", "type": "external" }, { "id": "2.7.7.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.23", "type": "external" }, { "id": "2.7.7.83", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.83", "type": "external" } ], "go_molecular_function": "GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0090406 pollen tube", "go_biological_process": "GO:0005977 glycogen metabolic process;GO:0006011 UDP-alpha-D-glucose metabolic process;GO:0005985 sucrose metabolic process;GO:0016036 cellular response to phosphate starvation;GO:0009555 pollen development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9M9P3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.100000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55034-1", "uniprot_id": [ { "id": "PSMD4_ARATH", "url": "https://www.uniprot.org/uniprot/P55034", "type": "external" } ], "mass": 40757.0, "length": 386, "protein_name": "26S proteasome non-ATPase regulatory subunit 4 homolog", "gene_name": "RPN10", "organism": "Arabidopsis", "refseq_name": "regulatory particle non-ATPase 10", "refseq_ac": [ { "id": "NP_195575", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_195575", "type": "external" } ], "gene_names_uniprotkb": "RPN10; F20M13.190; MBP1; MCB1; T9A14.7", "gene_names_refseq": "ATMCB1; MBP1; MCB1; MULTIUBIQUITIN CHAIN BINDING PROTEIN 1; MULTIUBIQUITIN CHAIN BINDING PROTEIN; MULTIUBIQUITIN-CHAIN-BINDING PROTEIN 1; RPN10; T9A14.7; regulatory particle non-ATPase 10", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 4 homolog; 26S proteasome regulatory subunit RPN10; 26S proteasome regulatory subunit S5A homolog; AtMCB1; AtRPN10; Multiubiquitin chain-binding protein 1", "protein_names_refseq": "regulatory particle non-ATPase 10", "tax_id": 3702, "disease": "", "pathway": " (ath:AT4G38630)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10617198;12671091;14593172;14623884;17880284;17971041;18433157;19321709;19376835;20059542;20086187;20399133;20516081;21764993;21768351;22751321;23328941;23660473;23776212;25561503;27862469;28011693;29654922;30833711;8530351;8570648;9442033;9741626", "class_list": "", "function": "Plays a role in maintaining the structural integrity of the 19S regulatory particle (RP), subcomplex of the 26S proteasome. Plays a major role in both the direct and indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP). Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a potential docking subunit for both ubiquitin receptors RAD23s and DSK2s. Plays a role in the growth and development via the proteasome-dependent degradation of the ABA-signaling protein ABI5/DPBF1. Plays an important role for balancing cell expansion with cell proliferation rates during shoot development., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8L9G3", "ec_number_list": [], "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding;GO:0001653 peptide receptor activity", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006974 DNA damage response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0009651 response to salt stress;GO:0009744 response to sucrose;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P55034-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.100000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9FKS5-1", "uniprot_id": [ { "id": "CYC1B_ARATH", "url": "https://www.uniprot.org/uniprot/Q9FKS5", "type": "external" } ], "mass": 33690.0, "length": 307, "protein_name": "Cytochrome c1 2, heme protein, mitochondrial", "gene_name": "CYC1-2", "organism": "Arabidopsis", "refseq_name": "Cytochrome C1 family", "refseq_ac": [ { "id": "NP_001154756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001154756", "type": "external" } ], "gene_names_uniprotkb": "CYC1-2; MHK7.4", "gene_names_refseq": "MHK7.4; MHK7_4", "protein_names_uniprotkb": "Cytochrome c1 2, heme protein, mitochondrial; Complex III subunit 4-2; Complex III subunit IV-2; Cytochrome b-c1 complex subunit 4-2; Cytochrome c-1 2; Ubiquinol-cytochrome c reductase complex cytochrome c1 subunit 2", "protein_names_refseq": "Cytochrome C1 family", "tax_id": 3702, "disease": "", "pathway": " (ath:AT5G40810)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12970493;14593172;18189341;18305213;27862469;9679202", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F4KIR8;Q0WL66;Q0WNJ4;Q42065;Q94A63", "ec_number_list": [], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005773 vacuole;GO:0045275 respiratory chain complex III;GO:0009536 plastid", "go_biological_process": "GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9FKS5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.100000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46077-1", "uniprot_id": [ { "id": "14334_ARATH", "url": "https://www.uniprot.org/uniprot/P46077", "type": "external" } ], "mass": 30194.0, "length": 267, "protein_name": "14-3-3-like protein GF14 phi", "gene_name": "GF14; GRF4", "organism": "Arabidopsis", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GF14; GRF4; 14-3-3PHI; GENERAL REGULATORY FACTOR 4; GF14 PHI; GF14 protein phi chain; GRF4; T32G9.30; T32G9_30", "gene_names_refseq": "", "protein_names_uniprotkb": "14-3-3-like protein GF14 phi; General regulatory factor 4", "protein_names_refseq": "", "tax_id": 3702, "disease": "", "pathway": " (ath:AT1G35160)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "11130712;17317660;18463617;19245862;19376835;20466843;22223895;23111157;23328941;23572148;23660473;23776212;25256212;25561503;25661797;26091701;26187819;27862469;30833711;7972511;9276953", "class_list": "", "function": "Is associated with a DNA binding complex that binds to the G box, a well-characterized cis-acting DNA regulatory element found in plant genes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0045309 protein phosphorylated amino acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction;GO:0008104 intracellular protein localization;GO:0009742 brassinosteroid mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P46077-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.100000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F4HZB2-1", "uniprot_id": [ { "id": "BCHA1_ARATH", "url": "https://www.uniprot.org/uniprot/F4HZB2", "type": "external" } ], "mass": 400894.0, "length": 3601, "protein_name": "Protein SPIRRIG", "gene_name": "SPI", "organism": "Arabidopsis", "refseq_name": "BEACH-DOMAIN HOMOLOG A1", "refseq_ac": [ { "id": "NP_001322129", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001322129", "type": "external" } ], "gene_names_uniprotkb": "SPI; BCHA1; F10O3.12; F10O3_12; SPIRRIG", "gene_names_refseq": "F10O3.12; F10O3_12; SPIRRIG; SPI", "protein_names_uniprotkb": "Protein SPIRRIG; BEACH domain-containing protein A1; BEACH-domain homolog A1", "protein_names_refseq": "BEACH-DOMAIN HOMOLOG A1", "tax_id": 3702, "disease": "", "pathway": " (ath:AT1G03060)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11130712;19392685;20466843;21768351;22060019;23328941;23572148;23660473;23776212;25561503;25618824;26133670;26187819;27862469;29167316;29654922", "class_list": "", "function": "Involved in cell morphogenesis (PubMed:19392685). May have a function in membrane fusion or membrane composition (PubMed:19392685). Required for salt stress tolerance (PubMed:26133670). Regulates the salt stress-dependent post-transcriptional stabilization, cytoplasmic agglomeration, and localization to P-bodies of a subset of salt stress-regulated mRNAs (PubMed:26133670)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9SA64", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body;GO:0035619 root hair tip", "go_biological_process": "GO:0009825 multidimensional cell growth;GO:0071472 cellular response to salt stress;GO:0033962 P-body assembly;GO:0007033 vacuole organization;GO:1904580 regulation of intracellular mRNA localization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "F4HZB2-1", "record_type": "protein", "filter_code": "0000000.0000101.001000.100000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9SJF3-1", "uniprot_id": [ { "id": "DCP1_ARATH", "url": "https://www.uniprot.org/uniprot/Q9SJF3", "type": "external" } ], "mass": 40611.0, "length": 367, "protein_name": "mRNA-decapping enzyme-like protein", "gene_name": "T27G7.7", "organism": "Arabidopsis", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "T27G7.7", "gene_names_refseq": "", "protein_names_uniprotkb": "mRNA-decapping enzyme-like protein; 3.-.-.-; DCP1 homolog", "protein_names_refseq": "", "tax_id": 3702, "disease": "", "pathway": " (ath:AT1G08370)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11130712;17158604;17485080;19855049;22407295;23111157;23328941;25561503;26133670;27862469", "class_list": "", "function": "As a component of the decapping complex, involved in the degradation of mRNAs. Essential for postembryonic development., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O64895", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0008047 enzyme activator activity;GO:0016787 hydrolase activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0006397 mRNA processing;GO:0006952 defense response;GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9SJF3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.100000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q94A97-1", "uniprot_id": [ { "id": "UBC35_ARATH", "url": "https://www.uniprot.org/uniprot/Q94A97", "type": "external" } ], "mass": 17192.0, "length": 153, "protein_name": "Ubiquitin-conjugating enzyme E2 35", "gene_name": "UBC35", "organism": "Arabidopsis", "refseq_name": "ubiquitin-conjugating enzyme 35", "refseq_ac": [ { "id": "NP_001031298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001031298", "type": "external" } ], "gene_names_uniprotkb": "UBC35; F9K20.8; F9K20_8; UBC13A; UBG13A", "gene_names_refseq": "F9K20.8; F9K20_8; UBC13A; UBC35; UBIQUITIN CONJUGATING ENZYME 13A; ubiquitin-conjugating enzyme 35", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 35; 2.3.2.23; E2 ubiquitin-conjugating enzyme 35; Ubiquitin carrier protein 35", "protein_names_refseq": "ubiquitin-conjugating enzyme 35", "tax_id": 3702, "disease": "", "pathway": " (ath:AT1G78870)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11130712;14593172;16339806;16786304;17586653;18178771;20113438;25561503;27862469", "class_list": "", "function": "Catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Required for postreplication repair of UV-damaged DNA and for adapting root developmental programs to suboptimal availability of iron., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q2V4C1;Q9ZVA6", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0031372 UBC13-MMS2 complex;GO:0009507 chloroplast", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process;GO:0010039 response to iron ion;GO:0070534 protein K63-linked ubiquitination;GO:0006301 DNA damage tolerance;GO:0010053 root epidermal cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q94A97-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.100000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q84L32-1", "uniprot_id": [ { "id": "RD23A_ARATH", "url": "https://www.uniprot.org/uniprot/Q84L32", "type": "external" } ], "mass": 39842.0, "length": 368, "protein_name": "Probable ubiquitin receptor RAD23a", "gene_name": "RAD23A", "organism": "Arabidopsis", "refseq_name": "Rad23 UV excision repair protein family", "refseq_ac": [ { "id": "NP_173070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_173070", "type": "external" } ], "gene_names_uniprotkb": "RAD23A; F3O9.1; RAD23-2; RAD23; RADIATION SENSITIVE23A", "gene_names_refseq": "RAD23A; RADIATION SENSITIVE23A", "protein_names_uniprotkb": "Probable ubiquitin receptor RAD23a; AtRAD23-2; AtRAD23a; Putative DNA repair protein RAD23-2; RAD23-like protein 2", "protein_names_refseq": "Rad23 UV excision repair protein family", "tax_id": 3702, "disease": "", "pathway": " (ath:AT1G16190)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11130712;20086187;20399133;27862469;29283431", "class_list": "", "function": "May be involved in nucleotide excision repair (By similarity). Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP) (By similarity). Involved in UV tolerance in roots, specifically in dark conditions (PubMed:29283431)., [UniProtKB, PubMed]; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9S9L8;Q9SA20", "ec_number_list": [], "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding;GO:0003684 damaged DNA binding;GO:0043130 ubiquitin binding;GO:0070628 proteasome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0009411 response to UV;GO:0006289 nucleotide-excision repair;GO:0009650 UV protection", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q84L32-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.100000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q84L31-1", "uniprot_id": [ { "id": "RD23C_ARATH", "url": "https://www.uniprot.org/uniprot/Q84L31", "type": "external" } ], "mass": 44247.0, "length": 419, "protein_name": "Ubiquitin receptor RAD23c", "gene_name": "RAD23C", "organism": "Arabidopsis", "refseq_name": "Rad23 UV excision repair protein family", "refseq_ac": [ { "id": "NP_186903", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_186903", "type": "external" } ], "gene_names_uniprotkb": "RAD23C; F16B3.17; F16B3_17; RAD23-3; RAD23; RADIATION SENSITIVE23C", "gene_names_refseq": "F16B3.17; F16B3_17; PUTATIVE DNA REPAIR PROTEIN RAD23-3; RAD23-3; RAD23C; RADIATION SENSITIVE23C", "protein_names_uniprotkb": "Ubiquitin receptor RAD23c; AtRAD23-3; AtRAD23c; Putative DNA repair protein RAD23-3; RAD23-like protein 3", "protein_names_refseq": "Rad23 UV excision repair protein family", "tax_id": 3702, "disease": "", "pathway": " (ath:AT3G02540)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11130713;14593172;20059542;20086187;20399133;21764993;23111157;27862469;29283431", "class_list": "", "function": "May be involved in nucleotide excision repair (By similarity). Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP). Involved in UV tolerance in hypocotyls, specifically in dark conditions (PubMed:29283431)., [UniProtKB, PubMed, PubMed, PubMed]; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9M887", "ec_number_list": [], "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding;GO:0003684 damaged DNA binding;GO:0043130 ubiquitin binding;GO:0070628 proteasome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0009411 response to UV;GO:0006289 nucleotide-excision repair;GO:0009650 UV protection", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q84L31-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.100000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9C5Q8-1", "uniprot_id": [ { "id": "HEN1_ARATH", "url": "https://www.uniprot.org/uniprot/Q9C5Q8", "type": "external" } ], "mass": 104454.0, "length": 942, "protein_name": "Small RNA 2'-O-methyltransferase", "gene_name": "HEN1", "organism": "Arabidopsis", "refseq_name": "double-stranded RNA binding protein-related / DsRBD protein-like protein", "refseq_ac": [ { "id": "NP_001190782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001190782", "type": "external" } ], "gene_names_uniprotkb": "HEN1; CRM2; T13K14.70", "gene_names_refseq": "CORYMBOSA 2; CRM2; HEN1; HUA ENHANCER 1; T13K14.70; T13K14_70", "protein_names_uniprotkb": "Small RNA 2'-O-methyltransferase; 2.1.1.386; Protein CORYMBOSA 2; Protein HUA ENHANCER 1; S-adenosylmethionine-dependent RNA methyltransferase HEN1", "protein_names_refseq": "double-stranded RNA binding protein-related / DsRBD protein-like protein", "tax_id": 3702, "disease": "", "pathway": " (ath:AT4G20910)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10617198;11874905;11917084;15024409;15705854;16111943;18463617;19812675;20466843;23328941;23572148;23660473;23776212;25561503;26091701;27862469;28011693;30833711", "class_list": "", "function": "Methyltransferase that adds a methyl group to the ribose of the last nucleotide of small RNAs (sRNAs). This protects the 3'-end of sRNAs from uridylation activity and subsequent degradation. Can methylate 3'-end of microRNAs (miRNAs), small interfering RNAs (siRNas) and trans-acting small interfering RNAs (ta-siRNAs). Involved in plant development through its role in small RNAs processing. Required for the specification of reproductive organ identities and the probable repression of A class genes. May control floral determinacy possibly by regulating the expression of the C class floral homeotic gene AGAMOUS (AG)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O65309;Q945R3;Q9SUC2", "ec_number_list": [ { "id": "2.1.1.386", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.386", "type": "external" } ], "go_molecular_function": "GO:0090486 small RNA 2'-O-methyltransferase activity;GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0008171 O-methyltransferase activity;GO:0008173 RNA methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0035196 miRNA processing;GO:0030422 siRNA processing;GO:0035279 miRNA-mediated gene silencing by mRNA destabilization;GO:0034587 piRNA processing;GO:0001510 RNA methylation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9C5Q8-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.100000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q75W54-1", "uniprot_id": [ { "id": "EBM_ARATH", "url": "https://www.uniprot.org/uniprot/Q75W54", "type": "external" } ], "mass": 107661.0, "length": 944, "protein_name": "Mannosylglycoprotein endo-beta-mannosidase", "gene_name": "EBM", "organism": "Arabidopsis", "refseq_name": "glycoside hydrolase family 2 protein", "refseq_ac": [ { "id": "NP_563833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_563833", "type": "external" } ], "gene_names_uniprotkb": "EBM; F7G19.12", "gene_names_refseq": "F7G19.12; F7G19_12", "protein_names_uniprotkb": "Mannosylglycoprotein endo-beta-mannosidase; 3.2.1.152; AtEBM; Endo-beta-mannosidase", "protein_names_refseq": "glycoside hydrolase family 2 protein", "tax_id": 3702, "disease": "", "pathway": " (ath:AT1G09010)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11130712;15247239;27862469", "class_list": "glycogene;glycosylhydrolase", "function": "Glycosidase that specifically hydrolyzes the Man-beta-1,4-GlcNAc linkage in the trimannosyl core structure of N-glycans. Does not hydrolyzes pyridylamino derivatives sugar chains containing Man-alpha-1,3-Man-beta or Xylose-beta-1,2-Man-beta., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 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CALCINEURIN B-LIKE PROTEIN 4; CBL4; MOP9.19; MOP9.8; MOP9_19; SALT OVERLY SENSITIVE 3; SOS3", "gene_names_refseq": "ATSOS3; CALCINEURIN B-LIKE PROTEIN 4; CBL4; MOP9.19; MOP9_19; SALT OVERLY SENSITIVE 3; SOS3", "protein_names_uniprotkb": "Calcineurin B-like protein 4; Protein SALT OVERLY SENSITIVE 3", "protein_names_refseq": "Calcium-binding EF-hand family protein", "tax_id": 3702, "disease": "", "pathway": " (ath:AT5G24270)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10590166;10725350;11006339;11130714;12034882;14593172;14730064;15644219;17499048;18502848;19832944;21445098;22253446;23052592;26315018;27862469;9405937;9632394", "class_list": "", "function": "Acts as a calcium sensor involved in the regulatory pathway for the control of intracellular Na(+) and K(+) homeostasis and salt tolerance. Binding of a CBL protein to the regulatory NAF domain of a CIPK serine-threonine protein kinase lead to the activation of the kinase in a calcium-dependent manner. Operates in synergy with CIPK24/SOS2 to activate the plasma membrane Na(+)/H(+) antiporter SOS1. Involved in salt stress responses by mediating calcium-dependent microfilament reorganization. The CBL4/CIPK6 complex mediates translocation of AKT2 from the endoplasmic reticulum to the plasma membrane. Both myristoylation and S-acylation are required for AKT2 activation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Acts as a calcium sensor. CBL proteins interact with CIPK serine-threonine protein kinases. Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0019900 kinase binding;GO:0004723 calcium-dependent protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005955 calcineurin complex;GO:0016020 membrane", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0071472 cellular response to salt stress;GO:0005513 detection of calcium ion;GO:0030007 intracellular potassium ion homeostasis;GO:0042539 hypotonic salinity response", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "O81223-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.100000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O64629-1", "uniprot_id": [ { "id": "AUR3_ARATH", "url": "https://www.uniprot.org/uniprot/O64629", "type": "external" } ], "mass": 33119.0, "length": 288, "protein_name": "Serine/threonine-protein kinase Aurora-3", "gene_name": "AUR3", "organism": "Arabidopsis", "refseq_name": "ataurora3", "refseq_ac": [ { "id": "NP_182073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_182073", "type": "external" } ], "gene_names_uniprotkb": "AUR3; AtAUR3; F17K2.2; ataurora3", "gene_names_refseq": "AUR3; AtAUR3; F17K2.2; ataurora3", "protein_names_uniprotkb": "Serine/threonine-protein kinase Aurora-3; 2.7.11.1; AtAur3; Aurora-like kinase 3", "protein_names_refseq": "ataurora3", "tax_id": 3702, "disease": "", "pathway": " (ath:AT2G45490)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10617197;14593172;15469496;15722465;16028112;17087760;27862469", "class_list": "", "function": "Phosphorylates in vitro histone H3 at 'Ser-10' (H3S10ph) and 'Ser-28' (H3S28ph), but not at 'Thr-3' (H3T3ph) or 'Thr-11' (H3T11ph). Colocalizes with phosphorylated histone H3 during mitosis. Associates with cytoskeletal structures that are necessary for cytokinesis and with the microtubule spindle., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.-", "type": "external" }, { "id": "3.1.4.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.46", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "4.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0035175 histone H3S10 kinase activity;GO:0106310 protein serine kinase activity;GO:0044022 histone H3S28 kinase activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005819 spindle;GO:0048471 perinuclear region of cytoplasm;GO:0051233 spindle midzone;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0043687 post-translational protein modification;GO:0016310 phosphorylation;GO:0007052 mitotic spindle organization;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O64629-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.100000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O24495-1", "uniprot_id": [ { "id": "GLO2M_ARATH", "url": "https://www.uniprot.org/uniprot/O24495", "type": "external" } ], "mass": 36500.0, "length": 331, "protein_name": "Hydroxyacylglutathione hydrolase 1, mitochondrial", "gene_name": "GLX2-1", "organism": "Arabidopsis", "refseq_name": "glyoxalase 2-1", "refseq_ac": [ { "id": "NP_565999", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_565999", "type": "external" } ], "gene_names_uniprotkb": "GLX2-1; GLY1; GLYOXALASE II; T1O24.17; glyoxalase 2-1", "gene_names_refseq": "GLX2-1; GLY1; GLYOXALASE II; T1O24.17; glyoxalase 2-1", "protein_names_uniprotkb": "Hydroxyacylglutathione hydrolase 1, mitochondrial; 3.1.2.6; Glx II; Glyoxalase II", "protein_names_refseq": "glyoxalase 2-1", "tax_id": 3702, "disease": "", "pathway": " (ath:AT2G43430)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10617197;14593172;27862469;9349270", "class_list": "", "function": "Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O22857;O24494", "ec_number_list": [ { "id": "3.1.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.6", "type": "external" } ], "go_molecular_function": "GO:0004416 hydroxyacylglutathione hydrolase activity;GO:0008270 zinc ion binding;GO:0046872 metal ion binding;GO:0008800 beta-lactamase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0009507 chloroplast", "go_biological_process": "GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione;GO:0009651 response to salt stress;GO:0043200 response to amino acid;GO:0034059 response to anoxia;GO:0017001 antibiotic catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O24495-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.100000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O64645-1", "uniprot_id": [ { "id": "SOC1_ARATH", "url": "https://www.uniprot.org/uniprot/O64645", "type": "external" } ], "mass": 24533.0, "length": 214, "protein_name": "MADS-box protein SOC1", "gene_name": "AGL20; SOC1", "organism": "Arabidopsis", "refseq_name": "AGAMOUS-like 20", "refseq_ac": [ { "id": "NP_182090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_182090", "type": "external" } ], "gene_names_uniprotkb": "AGL20; SOC1; AGAMOUS-like 20; AGL20; ATSOC1; F17K2.19; MADS-BOX PROTEIN AGL20; SOC1", "gene_names_refseq": "AGAMOUS-like 20; AGL20; ATSOC1; F17K2.19; MADS-BOX PROTEIN AGL20; SOC1; SUPPRESSOR OF OVEREXPRESSION OF CO 1", "protein_names_uniprotkb": "MADS-box protein SOC1; Agamous-like MADS-box protein AGL20; Protein SUPPRESSOR OF CONSTANS OVEREXPRESSION 1", "protein_names_refseq": "AGAMOUS-like 20", "tax_id": 3702, "disease": "", "pathway": " (ath:AT2G45660)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10617197;10995392;11123798;14593172;15805477;17428825;18339670;18390846;18466303;19656343;25281686;27862469;31540691", "class_list": "", "function": "Transcription activator active in flowering time control. May integrate signals from the photoperiod, vernalization and autonomous floral induction pathways. Can modulate class B and C homeotic genes expression. When associated with AGL24, mediates effect of gibberellins on flowering under short-day conditions, and regulates the expression of LEAFY (LFY), which links floral induction and floral development., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009409 response to cold;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O64645-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.100000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O80358-1", "uniprot_id": [ { "id": "FPG_ARATH", "url": "https://www.uniprot.org/uniprot/O80358", "type": "external" } ], "mass": 43194.0, "length": 390, "protein_name": "Formamidopyrimidine-DNA glycosylase", "gene_name": "FPG1; MMH-1", "organism": "Arabidopsis", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FPG1; MMH-1; ATFPG-1; ATFPG-2; ATMMH-1; ATMMH-2; F6D8.28; F6D8.37; F6D8_37; FPG-1; FPG-2; FPG2; MMH-2; MMH; MUTM homolog-1; MUTM homolog", "gene_names_refseq": "", "protein_names_uniprotkb": "Formamidopyrimidine-DNA glycosylase; 3.2.2.23; 4.2.99.18; AtFPG-1; AtFPG-2; AtMMH-1; AtMMH-2; DNA-(apurinic or apyrimidinic site) lyase FPG1; Fapy-DNA glycosylase; Formamidopyrimidine-DNA glycosylase 1; Formamidopyrimidine-DNA glycosylase 2; Protein MutM homolog 1; Protein MutM homolog 2", "protein_names_refseq": "", "tax_id": 3702, "disease": "", "pathway": " (ath:AT1G52500)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11130712;11272725;11535407;19376835;20466843;21768351;22789755;23111157;23572148;23660473;23776212;26187819;27862469;30833711;9819050", "class_list": "", "function": "Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Can process efficiently 4,6-diamino-5-formamidopyrimidine (FapyA), 2,6-diamino-4- hydroxy-5-formamidopyrimidine (FapyG) and the further oxidation products of 8-oxoguanine (8-oxoG), such as guanidinohydantoin and spiroiminodihydantoin. Has marginal activity towards 8-oxoG. Has AP (apurinic/apyrimidinic) lyase activity. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O80359;Q9SBB4", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "3.2.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.23", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding;GO:0019104 DNA N-glycosylase activity;GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006281 DNA repair;GO:0006979 response to oxidative stress;GO:0006284 base-excision repair", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O80358-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.100000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O80796-1", "uniprot_id": [ { "id": "VIPP1_ARATH", "url": "https://www.uniprot.org/uniprot/O80796", "type": "external" } ], "mass": 36392.0, "length": 330, "protein_name": "Membrane-associated protein VIPP1, chloroplastic", "gene_name": "PTAC4; VIPP1", "organism": "Arabidopsis", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PTAC4; VIPP1; T8F5.2; T8F5_2; VIPP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Membrane-associated protein VIPP1, chloroplastic; Protein VESICLE-INDUCING PROTEIN IN PLASTIDS 1", "protein_names_refseq": "", "tax_id": 3702, "disease": "", "pathway": " (ath:AT1G65260)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11130712;11274447;14593172;17346982;22060019;25561503;27862469;28011693", "class_list": "", "function": "Required for plastid vesicle formation and thylakoid membrane biogenesis, but not for functional assembly of thylakoid protein complexes., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0009535 chloroplast thylakoid membrane;GO:0009507 chloroplast;GO:0009534 chloroplast thylakoid;GO:0009570 chloroplast stroma", "go_biological_process": "GO:0016050 vesicle organization;GO:0010027 thylakoid membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O80796-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.100000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O81645-1", "uniprot_id": [ { "id": "VILI3_ARATH", "url": "https://www.uniprot.org/uniprot/O81645", "type": "external" } ], "mass": 106349.0, "length": 965, "protein_name": "Villin-3", "gene_name": "VLN3", "organism": "Arabidopsis", "refseq_name": "villin 3", "refseq_ac": [ { "id": "NP_001319779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001319779", "type": "external" } ], "gene_names_uniprotkb": "VLN3; ATVLN3; F28O9.1; F28O9.260; T8H10.10; villin 3", "gene_names_refseq": "ATVLN3; F28O9.1; VLN3; villin 3", "protein_names_uniprotkb": "Villin-3", "protein_names_refseq": "villin 3", "tax_id": 3702, "disease": "", "pathway": " (ath:AT3G57410)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10631247;11130713;19376835;19423640;20807878;21768351;22060019;22209875;22563899;23111157;23172892;23572148;23660473;23776212;24043427;24601666;25561503;26091701;27862469;28011693;29167316;29654922;30833711", "class_list": "", "function": "Binds actin and actin filament bundles in a Ca(2+)-insensitive manner, but severs actin filaments in a calcium-dependent manner, regardless of the presence or not of VLN1 (AC O81643). Acts redundantly with VLN2 (AC O81644) to generate thick actin filament bundles, to regulate directional organ growth (PubMed:22209875) and in sclerenchyma development (PubMed:22563899)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A1I9LLW4;C0Z212;Q9LEA4;Q9SCN1", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0015629 actin cytoskeleton;GO:0005856 cytoskeleton", "go_biological_process": "GO:0051017 actin filament bundle assembly;GO:0051014 actin filament severing;GO:0051693 actin filament capping;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "O81645-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.100000000000000000.0000000001001.001.00000", "kg_view_protein": true } ]