[ { "uniprot_canonical_ac": "P26662-1", "uniprot_ac": "P26662", "uniprot_id": "POLG_HCVJA", "mass": { "chemical_mass": 327021.0, "monoisotopic_mass": 327021.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Genome polyprotein", "type": "recommended", "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662/entry#names_and_taxonomy" } ] }, { "name": "Capsid protein C", "type": "synonym", "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662/entry#names_and_taxonomy" } ] }, { "name": "Hepacivirin", "type": "synonym", "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662/entry#names_and_taxonomy" } ] }, { "name": "NS1", "type": "synonym", "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662/entry#names_and_taxonomy" } ] }, { "name": "NS2", "type": "synonym", "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662/entry#names_and_taxonomy" } ] }, { "name": "NS3 helicase", "type": "synonym", "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662/entry#names_and_taxonomy" } ] }, { "name": "NS3 protease", "type": "synonym", "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662/entry#names_and_taxonomy" } ] }, { "name": "NS3P", "type": "synonym", "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662/entry#names_and_taxonomy" } ] }, { "name": "NS5B", "type": "synonym", "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662/entry#names_and_taxonomy" } ] }, { "name": "Non-structural protein 2", "type": "synonym", "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662/entry#names_and_taxonomy" } ] }, { "name": "Viroporin p70", "type": "synonym", "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662/entry#names_and_taxonomy" } ] }, { "name": "gp32", "type": "synonym", "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662/entry#names_and_taxonomy" } ] }, { "name": "gp35", "type": "synonym", "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662/entry#names_and_taxonomy" } ] }, { "name": "gp68", "type": "synonym", "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662/entry#names_and_taxonomy" } ] }, { "name": "gp70", "type": "synonym", "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662/entry#names_and_taxonomy" } ] }, { "name": "p21", "type": "synonym", "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662/entry#names_and_taxonomy" } ] }, { "name": "p23", "type": "synonym", "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662/entry#names_and_taxonomy" } ] }, { "name": "p27", "type": "synonym", "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662/entry#names_and_taxonomy" } ] }, { "name": "p56/58", "type": "synonym", "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662/entry#names_and_taxonomy" } ] }, { "name": "p68", "type": "synonym", "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662/entry#names_and_taxonomy" } ] }, { "name": "p8", "type": "synonym", "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Cysteine protease required for the proteolytic auto-cleavage between the non-structural proteins NS2 and NS3 (By similarity). The N-terminus of NS3 is required for the function of NS2 protease (active region NS2-3) (By similarity). Promotes the initiation of viral particle assembly by mediating the interaction between structural and non-structural proteins (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662#function" }, { "database": "UniProtKB", "id": "P26663", "url": "https://www.uniprot.org/uniprotkb/P26663#function" }, { "database": "UniProtKB", "id": "P27958", "url": "https://www.uniprot.org/uniprotkb/P27958#function" }, { "database": "UniProtKB", "id": "Q99IB8", "url": "https://www.uniprot.org/uniprotkb/Q99IB8#function" } ] }, { "annotation": "Displays three enzymatic activities: serine protease with a chymotrypsin-like fold, NTPase and RNA helicase (By similarity). NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B (By similarity). The NS3/NS4A complex prevents phosphorylation of host IRF3, thus preventing the establishment of dsRNA induced antiviral state (By similarity). The NS3/NS4A complex induces host amino acid transporter component SLC3A2, thus contributing to HCV propagation (By similarity). NS3 RNA helicase binds to RNA and unwinds both dsDNA and dsRNA in the 3' to 5' direction, and likely resolves RNA complicated stable secondary structures in the template strand (By similarity). Binds a single ATP and catalyzes the unzipping of a single base pair of dsRNA (By similarity). Inhibits host antiviral proteins TBK1 and IRF3 thereby preventing the establishment of an antiviral state (By similarity). Cleaves host MAVS/CARDIF thereby preventing the establishment of an antiviral state (By similarity). Cleaves host TICAM1/TRIF, thereby disrupting TLR3 signaling and preventing the establishment of an antiviral state (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662#function" }, { "database": "UniProtKB", "id": "P27958", "url": "https://www.uniprot.org/uniprotkb/P27958#function" }, { "database": "UniProtKB", "id": "Q9WMX2", "url": "https://www.uniprot.org/uniprotkb/Q9WMX2#function" } ] }, { "annotation": "Forms a heterodimer with envelope glycoprotein E1, which mediates virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane (By similarity). Fusion with the host cell is most likely mediated by both E1 and E2, through conformational rearrangements of the heterodimer required for fusion rather than a classical class II fusion mechanism (By similarity). The interaction between envelope glycoprotein E2 and host apolipoprotein E/APOE allows the proper assembly, maturation and infectivity of the viral particles (By similarity). This interaction is probably promoted via the up-regulation of cellular autophagy by the virus (By similarity). E1/E2 heterodimer binds host apolipoproteins such as APOB and APOE thereby forming a lipo-viro-particle (LVP) (By similarity). APOE associated to the LVP allows the initial virus attachment to cell surface receptors such as the heparan sulfate proteoglycans (HSPGs), syndecan-1 (SDC1), syndecan-1 (SDC2), the low-density lipoprotein receptor (LDLR) and scavenger receptor class B type I (SCARB1) (By similarity). The cholesterol transfer activity of SCARB1 allows E2 exposure and binding of E2 to SCARB1 and the tetraspanin CD81 (By similarity). E1/E2 heterodimer binding on CD81 activates the epithelial growth factor receptor (EGFR) signaling pathway (By similarity). Diffusion of the complex E1-E2-EGFR-SCARB1-CD81 to the cell lateral membrane allows further interaction with Claudin 1 (CLDN1) and occludin (OCLN) to finally trigger HCV entry (By similarity). Inhibits host EIF2AK2/PKR activation, preventing the establishment of an antiviral state (By similarity). Viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses (By similarity). These interactions allow the capture of circulating HCV particles by these cells and subsequent facilitated transmission to permissive cells such as hepatocytes and lymphocyte subpopulations (By similarity). The interaction between E2 and host amino acid transporter complex formed by SLC3A2 and SLC7A5/LAT1 may facilitate viral entry into host cell (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662#function" }, { "database": "UniProtKB", "id": "P27958", "url": "https://www.uniprot.org/uniprotkb/P27958#function" }, { "database": "UniProtKB", "id": "P26664", "url": "https://www.uniprot.org/uniprotkb/P26664#function" } ] }, { "annotation": "Forms a heterodimer with envelope glycoprotein E2, which mediates virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane (By similarity). Fusion with the host cell is most likely mediated by both E1 and E2, through conformational rearrangements of the heterodimer required for fusion rather than a classical class II fusion mechanism (By similarity). E1/E2 heterodimer binds host apolipoproteins such as APOB and APOE thereby forming a lipo-viro-particle (LVP) (By similarity). APOE associated to the LVP allows the initial virus attachment to cell surface receptors such as the heparan sulfate proteoglycans (HSPGs), syndecan-1 (SDC1), syndecan-1 (SDC2), the low-density lipoprotein receptor (LDLR) and scavenger receptor class B type I (SCARB1) (By similarity). The cholesterol transfer activity of SCARB1 allows E2 exposure and binding of E2 to SCARB1 and the tetraspanin CD81 (By similarity). E1/E2 heterodimer binding on CD81 activates the epithelial growth factor receptor (EGFR) signaling pathway (By similarity). Diffusion of the complex E1-E2-EGFR-SCARB1-CD81 to the cell lateral membrane allows further interaction with Claudin 1 (CLDN1) and occludin (OCLN) to finally trigger HCV entry (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662#function" }, { "database": "UniProtKB", "id": "P27958", "url": "https://www.uniprot.org/uniprotkb/P27958#function" } ] }, { "annotation": "Induces a specific membrane alteration that serves as a scaffold for the virus replication complex (By similarity). This membrane alteration gives rise to the so-called ER-derived membranous web that contains the replication complex (By similarity). NS4B self-interaction contributes to its function in membranous web formation (By similarity). Promotes host TRIF protein degradation in a CASP8-dependent manner thereby inhibiting host TLR3-mediated interferon signaling (By similarity). Disrupts the interaction between STING and TBK1 contributing to the inhibition of interferon signaling (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662#function" }, { "database": "UniProtKB", "id": "P27958", "url": "https://www.uniprot.org/uniprotkb/P27958#function" } ] }, { "annotation": "Ion channel protein that acts as a viroporin and plays an essential role in the assembly, envelopment and secretion of viral particles (PubMed:20667830). Regulates the host cell secretory pathway, which induces the intracellular retention of viral glycoproteins and favors assembly of viral particles (By similarity). Creates a pore in acidic organelles and releases Ca(2+) and H(+) in the cytoplasm of infected cells, leading to a productive viral infection (By similarity). High levels of cytoplasmic Ca(2+) may trigger membrane trafficking and transport of viral ER-associated proteins to viroplasms, sites of viral genome replication (Probable). This ionic imbalance induces the assembly of the inflammasome complex, which triggers the maturation of pro-IL-1beta into IL-1beta through the action of caspase-1 (By similarity). Targets also host mitochondria and induces mitochondrial depolarization (By similarity). In addition of its role as a viroporin, acts as a lipid raft adhesion factor (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662#function" }, { "database": "UniProtKB", "id": "P27958", "url": "https://www.uniprot.org/uniprotkb/P27958#function" }, { "database": "UniProtKB", "id": "Q99IB8", "url": "https://www.uniprot.org/uniprotkb/Q99IB8#function" }, { "database": "PubMed", "id": "20667830", "url": "https://glygen.org/publication/PubMed/20667830" } ] }, { "annotation": "Packages viral RNA to form a viral nucleocapsid, and promotes virion budding (Probable). Participates in the viral particle production as a result of its interaction with the non-structural protein 5A (By similarity). Binds RNA and may function as a RNA chaperone to induce the RNA structural rearrangements taking place during virus replication (By similarity). Modulates viral translation initiation by interacting with viral IRES and 40S ribosomal subunit (PubMed:15760888). Affects various cell signaling pathways, host immunity and lipid metabolism (Probable). Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by blocking the formation of phosphorylated STAT1 and promoting ubiquitin-mediated proteasome-dependent degradation of STAT1 (PubMed:15825084, PubMed:16940534). Activates STAT3 leading to cellular transformation (By similarity). Regulates the activity of cellular genes, including c-myc and c-fos (By similarity). May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm (PubMed:14559998). Represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation (By similarity). Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NF-kappa-B activation, and activates AP-1 (By similarity). Binds to dendritic cells (DCs) via C1QR1, resulting in down-regulation of T-lymphocytes proliferation (By similarity). Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage (By similarity). Induces up-regulation of FAS promoter activity, and thereby contributes to the increased triglyceride accumulation in hepatocytes (steatosis) (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662#function" }, { "database": "UniProtKB", "id": "P29846", "url": "https://www.uniprot.org/uniprotkb/P29846#function" }, { "database": "UniProtKB", "id": "P27958", "url": "https://www.uniprot.org/uniprotkb/P27958#function" }, { "database": "UniProtKB", "id": "Q99IB8", "url": "https://www.uniprot.org/uniprotkb/Q99IB8#function" }, { "database": "PubMed", "id": "14559998", "url": "https://glygen.org/publication/PubMed/14559998" }, { "database": "PubMed", "id": "15760888", "url": "https://glygen.org/publication/PubMed/15760888" }, { "database": "PubMed", "id": "15825084", "url": "https://glygen.org/publication/PubMed/15825084" }, { "database": "UniProtKB", "id": "P26664", "url": "https://www.uniprot.org/uniprotkb/P26664#function" }, { "database": "PubMed", "id": "16940534", "url": "https://glygen.org/publication/PubMed/16940534" } ] }, { "annotation": "Peptide cofactor which forms a non-covalent complex with the N-terminal of NS3 serine protease (By similarity). The NS3/NS4A complex prevents phosphorylation of host IRF3, thus preventing the establishment of dsRNA induced antiviral state (By similarity). The NS3/NS4A complex induces host amino acid transporter component SLC3A2, thus contributing to HCV propagation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662#function" }, { "database": "UniProtKB", "id": "P27958", "url": "https://www.uniprot.org/uniprotkb/P27958#function" }, { "database": "UniProtKB", "id": "Q9WMX2", "url": "https://www.uniprot.org/uniprotkb/Q9WMX2#function" } ] }, { "annotation": "Phosphorylated protein that is indispensable for viral replication and assembly (By similarity). Both hypo- and hyperphosphorylated states are required for the viral life cycle (By similarity). The hyperphosphorylated form of NS5A is an inhibitor of viral replication (By similarity). Involved in RNA-binding and especially in binding to the viral genome (PubMed:16126720). Zinc is essential for RNA-binding (By similarity). Participates in the viral particle production as a result of its interaction with the mature viral core protein (By similarity). Its interaction with host VAPB may target the viral replication complex to vesicles (Probable). Down-regulates viral IRES translation initiation (PubMed:31585734). Mediates interferon resistance, presumably by interacting with and inhibiting host EIF2AK2/PKR (By similarity). Prevents BIN1-induced apoptosis (By similarity). Acts as a transcriptional activator of some host genes important for viral replication when localized in the nucleus (Probable) (PubMed:23468497). Via the interaction with host PACSIN2, modulates lipid droplet formation in order to promote virion assembly (By similarity). Modulates TNFRSF21/DR6 signaling pathway for viral propagation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662#function" }, { "database": "UniProtKB", "id": "P27958", "url": "https://www.uniprot.org/uniprotkb/P27958#function" }, { "database": "UniProtKB", "id": "Q99IB8", "url": "https://www.uniprot.org/uniprotkb/Q99IB8#function" }, { "database": "UniProtKB", "id": "Q9WMX2", "url": "https://www.uniprot.org/uniprotkb/Q9WMX2#function" }, { "database": "PubMed", "id": "31585734", "url": "https://glygen.org/publication/PubMed/31585734" }, { "database": "PubMed", "id": "16126720", "url": "https://glygen.org/publication/PubMed/16126720" }, { "database": "PubMed", "id": "16227268", "url": "https://glygen.org/publication/PubMed/16227268" }, { "database": "PubMed", "id": "23468497", "url": "https://glygen.org/publication/PubMed/23468497" }, { "database": "PubMed", "id": "9343247", "url": "https://glygen.org/publication/PubMed/9343247" } ] }, { "annotation": "RNA-dependent RNA polymerase that performs primer-template recognition and RNA synthesis during viral replication. Initiates RNA transcription/replication at a flavin adenine dinucleotide (FAD), resulting in a 5'- FAD cap on viral RNAs. In this way, recognition of viral 5' RNA by host pattern recognition receptors can be bypassed, thereby evading activation of antiviral pathways.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662#function" }, { "database": "UniProtKB", "id": "P27958", "url": "https://www.uniprot.org/uniprotkb/P27958#function" } ] } ], "disease": [ { "disease_id": "DOID:1883", "recommended_name": { "id": "DOID:1883", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1883", "name": "hepatitis C", "description": "A viral hepatitis that results_in inflammation located_in liver, has_material_basis_in hepatitis C virus (Hepacivirus hominis), which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice." }, "synonyms": [ { "id": "DOID:1883", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1883", "name": "NANBH", "description": "" }, { "id": "DOID:1883", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1883", "name": "Viral hepatitis C", "description": "" }, { "id": "DOID:1883", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1883", "name": "chronic hepatitis C", "description": "" }, { "id": "DOID:1883", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1883", "name": "hepatitis C infection", "description": "" }, { "id": "DOID:1883", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1883", "name": "hepatitis nonA nonB", "description": "" }, { "id": "MONDO:0005231", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005231", "name": "hepatitis C virus infection", "description": "A viral infection caused by the hepatitis C virus." }, { "id": "MONDO:0005231", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005231", "name": "Hepatitis C virus caused hepatitis", "description": "" }, { "id": "MONDO:0005231", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005231", "name": "Hepatitis C virus hepatitis", "description": "" }, { "id": "MONDO:0005231", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005231", "name": "NANBH", "description": "" }, { "id": "MONDO:0005231", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005231", "name": "hepatitis C infection", "description": "" }, { "id": "MONDO:0005231", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005231", "name": "hepatitis type C", "description": "" }, { "id": "MONDO:0005231", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005231", "name": "non-A, non-B Hepatitis", "description": "" }, { "id": "MONDO:0005231", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005231", "name": "chronic hepatitis C", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "GLY_000488", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000488" } ] }, { "disease_id": "DOID:5082", "recommended_name": { "id": "DOID:5082", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5082", "name": "liver cirrhosis", "description": "" }, "synonyms": [ { "id": "DOID:5082", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5082", "name": "Cirrhosis", "description": "" }, { "id": "DOID:5082", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:5082", "name": "cirrhosis of liver", "description": "" }, { "id": "MONDO:0005155", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005155", "name": "cirrhosis of liver", "description": "A disorder characterized by replacement of the liver parenchyma with fibrous tissue and regenerative nodules. It is usually caused by alcoholism, hepatitis B, and hepatitis C. Complications include the development of ascites, esophageal varices, bleeding, and hepatic encephalopathy." }, { "id": "MONDO:0005155", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005155", "name": "cirrhosis", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "GLY_000488", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000488" } ] }, { "disease_id": "DOID:684", "recommended_name": { "id": "DOID:684", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver." }, "synonyms": [ { "id": "DOID:684", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:684", "name": "Hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": 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"end_pos": 1009, "sequence_org": "E", "sequence_mut": "Q", "comment": "No effect on polyprotein processing.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "8392606", "url": "https://glygen.org/publication/PubMed/8392606" } ] }, { "start_pos": 1042, "end_pos": 1042, "sequence_org": "C", "sequence_mut": "A", "comment": "No effect on zinc-binding by serine protease NS3.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "9060645", "url": "https://glygen.org/publication/PubMed/9060645" } ] }, { "start_pos": 1058, "end_pos": 1058, "sequence_org": "E", "sequence_mut": "Q", "comment": "No effect on polyprotein processing.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "8392606", "url": 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No effect on zinc-binding by serine protease NS3.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "8392606", "url": "https://glygen.org/publication/PubMed/8392606" }, { "database": "PubMed", "id": "9060645", "url": "https://glygen.org/publication/PubMed/9060645" }, { "database": "PubMed", "id": "8389908", "url": "https://glygen.org/publication/PubMed/8389908" } ] }, { "start_pos": 1171, "end_pos": 1171, "sequence_org": "C", "sequence_mut": "A", "comment": "Reduced protease NS2 and serine protease NS3 activities.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "8392606", "url": "https://glygen.org/publication/PubMed/8392606" } ] }, { "start_pos": 1175, "end_pos": 1175, "sequence_org": "H", "sequence_mut": "A", "comment": "No effect on polyprotein processing. 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No effect on zinc-binding by serine protease NS3.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "8392606", "url": "https://glygen.org/publication/PubMed/8392606" }, { "database": "PubMed", "id": "9060645", "url": "https://glygen.org/publication/PubMed/9060645" } ] }, { "start_pos": 1199, "end_pos": 1199, "sequence_org": "E", "sequence_mut": "Q", "comment": "No effect on polyprotein processing.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "8392606", "url": "https://glygen.org/publication/PubMed/8392606" } ] }, { "start_pos": 1202, "end_pos": 1202, "sequence_org": "E", "sequence_mut": "Q", "comment": "No effect on polyprotein processing.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "8392606", "url": "https://glygen.org/publication/PubMed/8392606" } ] }, { "start_pos": 1227, "end_pos": 1227, "sequence_org": "H", "sequence_mut": "A", "comment": "No effect on polyprotein processing. No effect on zinc-binding by serine protease NS3.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "8392606", "url": "https://glygen.org/publication/PubMed/8392606" }, { "database": "PubMed", "id": "9060645", "url": "https://glygen.org/publication/PubMed/9060645" } ] }, { "start_pos": 1229, "end_pos": 1229, "sequence_org": "H", "sequence_mut": "A", "comment": "No effect on polyprotein processing. No effect on zinc-binding by serine protease NS3.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "8392606", "url": "https://glygen.org/publication/PubMed/8392606" }, { "database": "PubMed", "id": "9060645", "url": "https://glygen.org/publication/PubMed/9060645" } ] }, { "start_pos": 139, "end_pos": 139, "sequence_org": "L", "sequence_mut": "A", "comment": "Complete loss of core protein processing by host signal peptidase, no effect on the cleavage at core-E1 junction; when associated with A-140 and A-144.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "15163730", "url": "https://glygen.org/publication/PubMed/15163730" } ] }, { "start_pos": 140, "end_pos": 140, "sequence_org": "V", "sequence_mut": "A", "comment": "Complete loss of core protein processing by host signal peptidase, no effect on the cleavage at core-E1 junction; when associated with A-139 and A-144.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "15163730", "url": "https://glygen.org/publication/PubMed/15163730" } ] }, { "start_pos": 144, "end_pos": 144, "sequence_org": "L", "sequence_mut": "A", "comment": "Complete loss of core protein processing by host signal peptidase, no effect on the cleavage at core-E1 junction; when associated with A-139 and A-140.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "15163730", "url": "https://glygen.org/publication/PubMed/15163730" } ] }, { "start_pos": 176, "end_pos": 177, "sequence_org": "IF", "sequence_mut": "AL", "comment": "Complete loss of core protein processing by host signal peptidase.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "15163730", "url": "https://glygen.org/publication/PubMed/15163730" } ] }, { "start_pos": 178, "end_pos": 179, "sequence_org": "LL", "sequence_mut": "VV", "comment": "No effect on processing of the core protein.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "15163730", "url": "https://glygen.org/publication/PubMed/15163730" } ] }, { "start_pos": 181, "end_pos": 182, "sequence_org": "LL", "sequence_mut": "VV", "comment": "No effect on processing of the core protein.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "15163730", "url": "https://glygen.org/publication/PubMed/15163730" } ] }, { "start_pos": 183, "end_pos": 184, "sequence_org": "SC", "sequence_mut": "LA", "comment": "No effect on processing of the core protein.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "15163730", "url": "https://glygen.org/publication/PubMed/15163730" } ] }, { "start_pos": 183, "end_pos": 184, "sequence_org": "SC", "sequence_mut": "LV", "comment": "No effect on processing of the core protein.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "15163730", "url": "https://glygen.org/publication/PubMed/15163730" } ] }, { "start_pos": 2126, "end_pos": 2126, "sequence_org": "D", "sequence_mut": "E", "comment": "Complete loss of nuclear translocation of NS5A.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "23468497", "url": "https://glygen.org/publication/PubMed/23468497" } ] }, { "start_pos": 2194, "end_pos": 2194, "sequence_org": "S", "sequence_mut": "A", "comment": "No effect on NS5A hyperphosphorylation and on down-regulation of viral translation.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "7769656", "url": "https://glygen.org/publication/PubMed/7769656" }, { "database": "PubMed", "id": "31585734", "url": "https://glygen.org/publication/PubMed/31585734" } ] }, { "start_pos": 2194, "end_pos": 2194, "sequence_org": "S", "sequence_mut": "D", "comment": "No effect on down-regulation of viral translation.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "31585734", "url": "https://glygen.org/publication/PubMed/31585734" } ] }, { "start_pos": 2197, "end_pos": 2197, "sequence_org": "S", "sequence_mut": "A", "comment": "Loss of NS5A hyperphosphorylation; no effect on down-regulation of viral translation.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "7769656", "url": "https://glygen.org/publication/PubMed/7769656" }, { "database": "PubMed", "id": "31585734", "url": "https://glygen.org/publication/PubMed/31585734" } ] }, { "start_pos": 2197, "end_pos": 2197, "sequence_org": "S", "sequence_mut": "D", "comment": "No effect on down-regulation of viral translation.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "31585734", "url": "https://glygen.org/publication/PubMed/31585734" } ] }, { "start_pos": 2200, "end_pos": 2200, "sequence_org": "S", "sequence_mut": "A", "comment": "No effect on NS5A hyperphosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "7769656", "url": "https://glygen.org/publication/PubMed/7769656" } ] }, { "start_pos": 2201, "end_pos": 2201, "sequence_org": "S", "sequence_mut": "A", "comment": "Loss of NS5A hyperphosphorylation. Complete loss of NS5A-induced down-regulation of viral translation.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "7769656", "url": "https://glygen.org/publication/PubMed/7769656" }, { "database": "PubMed", "id": "31585734", "url": "https://glygen.org/publication/PubMed/31585734" } ] }, { "start_pos": 2201, "end_pos": 2201, "sequence_org": "S", "sequence_mut": "D", "comment": "No effect on down-regulation of viral translation; increased NS5A dimerization.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "31585734", "url": "https://glygen.org/publication/PubMed/31585734" } ] }, { "start_pos": 2202, "end_pos": 2202, "sequence_org": "S", "sequence_mut": "A", "comment": "No effect on NS5A hyperphosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "7769656", "url": "https://glygen.org/publication/PubMed/7769656" } ] }, { "start_pos": 2204, "end_pos": 2204, "sequence_org": "S", "sequence_mut": "A", "comment": "Loss of NS5A hyperphosphorylation. No effect on down-regulation of viral translation.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "7769656", "url": "https://glygen.org/publication/PubMed/7769656" }, { "database": "PubMed", "id": "31585734", "url": "https://glygen.org/publication/PubMed/31585734" } ] }, { "start_pos": 2204, "end_pos": 2204, "sequence_org": "S", "sequence_mut": "D", "comment": "Complete loss of NS5A-induced down-regulation of viral translation.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "31585734", "url": "https://glygen.org/publication/PubMed/31585734" } ] }, { "start_pos": 2207, "end_pos": 2207, "sequence_org": "S", "sequence_mut": "A", "comment": "No effect on NS5A hyperphosphorylation. No effect on down-regulation of viral translation.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "7769656", "url": "https://glygen.org/publication/PubMed/7769656" }, { "database": "PubMed", "id": "31585734", "url": "https://glygen.org/publication/PubMed/31585734" } ] }, { "start_pos": 2207, "end_pos": 2207, "sequence_org": "S", "sequence_mut": "D", "comment": "No effect on down-regulation of viral translation.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "31585734", "url": "https://glygen.org/publication/PubMed/31585734" } ] }, { "start_pos": 2210, "end_pos": 2210, "sequence_org": "S", "sequence_mut": "A", "comment": "No effect on NS5A hyperphosphorylation. Complete loss of NS5A-induced down-regulation of viral translation.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "7769656", "url": "https://glygen.org/publication/PubMed/7769656" }, { "database": "PubMed", "id": "31585734", "url": "https://glygen.org/publication/PubMed/31585734" } ] }, { "start_pos": 2210, "end_pos": 2210, "sequence_org": "S", "sequence_mut": "D", "comment": "No effect on down-regulation of viral translation; increased NS5A dimerization.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "31585734", "url": "https://glygen.org/publication/PubMed/31585734" } ] }, { "start_pos": 2221, "end_pos": 2221, "sequence_org": "S", "sequence_mut": "A", "comment": "No effect on NS5A hyperphosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "7769656", "url": "https://glygen.org/publication/PubMed/7769656" } ] }, { "start_pos": 2448, "end_pos": 2448, "sequence_org": "S", "sequence_mut": "A", "comment": "Partial loss of RNA-directed RNA polymerase phosphorylation. 60% loss of viral RNA replication.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "25031343", "url": "https://glygen.org/publication/PubMed/25031343" } ] }, { "start_pos": 2461, "end_pos": 2461, "sequence_org": "S", "sequence_mut": "A", "comment": "Partial loss of RNA-directed RNA polymerase phosphorylation. 30% loss of viral RNA replication.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "25031343", "url": "https://glygen.org/publication/PubMed/25031343" } ] }, { "start_pos": 922, "end_pos": 922, "sequence_org": "C", "sequence_mut": "A", "comment": "No effect on polyprotein processing.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "8392606", "url": "https://glygen.org/publication/PubMed/8392606" } ] }, { "start_pos": 932, "end_pos": 932, "sequence_org": "H", "sequence_mut": "A", "comment": "No effect on polyprotein processing.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "8392606", "url": "https://glygen.org/publication/PubMed/8392606" } ] }, { "start_pos": 952, "end_pos": 952, "sequence_org": "H", "sequence_mut": "A", "comment": "Complete loss of protease NS2 activity.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "8392606", "url": "https://glygen.org/publication/PubMed/8392606" } ] }, { "start_pos": 952, "end_pos": 952, "sequence_org": "H", "sequence_mut": "R", "comment": "Complete loss of protease NS2 activity.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "8392606", "url": "https://glygen.org/publication/PubMed/8392606" } ] }, { "start_pos": 972, "end_pos": 972, "sequence_org": "E", "sequence_mut": "Q", "comment": "Reduced protease NS2 activity.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "8392606", "url": "https://glygen.org/publication/PubMed/8392606" } ] }, { "start_pos": 980, "end_pos": 980, "sequence_org": "E", "sequence_mut": "Q", "comment": "No effect on polyprotein processing.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "8392606", "url": "https://glygen.org/publication/PubMed/8392606" } ] }, { "start_pos": 993, "end_pos": 993, "sequence_org": "C", "sequence_mut": "A", "comment": "Complete loss of protease NS2 activity.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "8392606", "url": "https://glygen.org/publication/PubMed/8392606" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Hepatitis C virus (isolate Japanese)", "taxid": 11116, "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "common_name": "HCV", "glygen_name": "HCV-Japanese", "reference_species": "Hepatitis C virus (isolate Japanese) [11116]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/P26662", "locus": {} } ], "crossref": [ { "id": "D89872", "url": "https://euhcvdb.lyon.inserm.fr/euHCVdb/do/displayHCVEntry?primaryAC=D89872", "database": 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"id": "4I31", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=4I31&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "4I32", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=4I32&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "4I33", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=4I33&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "4JMY", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=4JMY&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "4KTC", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=4KTC&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "20988", "url": "https://www.iedb.org/epitope/20988", "database": "IEDB", "categories": [ "Other" ] }, { "id": "37317", "url": "https://www.iedb.org/epitope/37317", "database": "IEDB", "categories": [ "Other" ] }, { "id": "5033", "url": 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"IPR002166", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002166", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002518", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002518", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002519", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002519", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002521", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002521", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002522", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002522", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002531", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002531", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002868", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002868", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007094", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007094", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011492", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011492", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013192", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013192", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013193", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013193", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", 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"https://www.ebi.ac.uk/interpro/entry/IPR043128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044896", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044896", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049913", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049913", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054175", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054175", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "pdb_00001dxp", "url": "https://www.rcsb.org/structure/pdb_00001dxp", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00001dy8", "url": "https://www.rcsb.org/structure/pdb_00001dy8", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00001dy9", "url": "https://www.rcsb.org/structure/pdb_00001dy9", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00001w3c", "url": "https://www.rcsb.org/structure/pdb_00001w3c", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00002k8j", "url": "https://www.rcsb.org/structure/pdb_00002k8j", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00003oyp", "url": "https://www.rcsb.org/structure/pdb_00003oyp", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00003p8n", "url": "https://www.rcsb.org/structure/pdb_00003p8n", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00003p8o", "url": "https://www.rcsb.org/structure/pdb_00003p8o", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00004a1t", "url": "https://www.rcsb.org/structure/pdb_00004a1t", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00004a1v", "url": "https://www.rcsb.org/structure/pdb_00004a1v", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00004a1x", "url": "https://www.rcsb.org/structure/pdb_00004a1x", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00004i31", "url": "https://www.rcsb.org/structure/pdb_00004i31", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00004i32", "url": "https://www.rcsb.org/structure/pdb_00004i32", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00004i33", "url": "https://www.rcsb.org/structure/pdb_00004i33", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00004jmy", "url": "https://www.rcsb.org/structure/pdb_00004jmy", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00004ktc", "url": "https://www.rcsb.org/structure/pdb_00004ktc", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1DXP", "url": "https://www.rcsb.org/structure/1DXP", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1DY8", "url": "https://www.rcsb.org/structure/1DY8", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1DY9", "url": "https://www.rcsb.org/structure/1DY9", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1W3C", "url": "https://www.rcsb.org/structure/1W3C", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2K8J", "url": "https://www.rcsb.org/structure/2K8J", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3OYP", "url": "https://www.rcsb.org/structure/3OYP", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3P8N", "url": "https://www.rcsb.org/structure/3P8N", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3P8O", "url": "https://www.rcsb.org/structure/3P8O", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4A1T", "url": "https://www.rcsb.org/structure/4A1T", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4A1V", "url": "https://www.rcsb.org/structure/4A1V", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4A1X", "url": "https://www.rcsb.org/structure/4A1X", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4I31", "url": "https://www.rcsb.org/structure/4I31", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4I32", "url": "https://www.rcsb.org/structure/4I32", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4I33", "url": "https://www.rcsb.org/structure/4I33", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4JMY", "url": "https://www.rcsb.org/structure/4JMY", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4KTC", "url": "https://www.rcsb.org/structure/4KTC", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00998", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00998", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01006", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01006", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01506", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01506", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01538", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01538", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01539", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01539", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01542", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01542", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01543", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01543", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01560", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01560", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02907", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02907", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07652", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07652", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08300", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08300", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08301", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08301", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12941", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12941", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22027", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22027", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P26662-1", "url": "https://www.uniprot.org/uniprotkb/P26662-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "hcv", "url": "https://www.viprbrc.org/brc/home.spg?decorator=flavi_hcv", "database": "ViPR", "categories": [ "Organism-specific" ] } ], "sequence": { "sequence": "MSTNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARRPEGRTWAQPGYPWPLYGNEGMGWAGWLLSPRGSRPSWGPTDPRRRSRNLGKVIDTLTCGFADLMGYIPLVGAPLGGAARALAHGVRVLEDGVNYATGNLPGCSFSIFLLALLSCLTIPASAYEVRNVSGIYHVTNDCSNSSIVYEAADMIMHTPGCVPCVRESNFSRCWVALTPTLAARNSSIPTTTIRRHVDLLVGAAALCSAMYVGDLCGSVFLVSQLFTFSPRRYETVQDCNCSIYPGHVSGHRMAWDMMMNWSPTTALVVSQLLRIPQAVVDMVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDGHTHVTGGRVASSTQSLVSWLSQGPSQKIQLVNTNGSWHINRTALNCNDSLQTGFIAALFYAHRFNASGCPERMASCRPIDEFAQGWGPITHDMPESSDQRPYCWHYAPRPCGIVPASQVCGPVYCFTPSPVVVGTTDRFGAPTYSWGENETDVLLLSNTRPPQGNWFGCTWMNSTGFTKTCGGPPCNIGGVGNNTLVCPTDCFRKHPEATYTKCGSGPWLTPRCMVDYPYRLWHYPCTVNFTVFKVRMYVGGVEHRLNAACNWTRGERCDLEDRDRSELSPLLLSTTEWQILPCSFTTLPALSTGLIHLHRNIVDVQYLYGIGSAVVSFAIKWEYILLLFLLLADARVCACLWMMLLIAQAEATLENLVVLNAASVAGAHGLLSFLVFFCAAWYIKGRLVPGAAYALYGVWPLLLLLLALPPRAYAMDREMAASCGGAVFVGLVLLTLSPYYKVFLARLIWWLQYFITRAEAHLQVWVPPLNVRGGRDAIILLTCAVHPELIFDITKLLLAILGPLMVLQAGITRVPYFVRAQGLIRACMLVRKVAGGHYVQMAFMKLAALTGTYVYDHLTPLRDWAHAGLRDLAVAVEPVVFSDMETKLITWGADTAACGDIISGLPVSARRGKEILLGPADSFGEQGWRLLAPITAYSQQTRGLLGCIITSLTGRDKNQVDGEVQVLSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWPAPPGARSMTPCTCGSSDLYLVTRHADVVPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPSGHVVGIFRAAVCTRGVAKAVDFIPVESMETTMRSPVFTDNSSPPAVPQTFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIEPNIRTGVRTITTGGPITYSTYCKFLADGGCSGGAYDIIICDECHSTDSTTILGIGTVLDQAETAGARLVVLATATPPGSITVPHPNIEEVALSNTGEIPFYGKAIPIEAIKGGRHLIFCHSKKKCDELAAKLTGLGLNAVAYYRGLDVSVIPTSGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRAQRRGRTGRGRSGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETSVRLRAYLNTPGLPVCQDHLEFWESVFTGLTHIDAHFLSQTKQAGDNLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEVTLTHPITKYIMACMSADLEVVTSTWVLVGGVLAALAAYCLTTGSVVIVGRIILSGRPAVIPDREVLYQEFDEMEECASHLPYIEQGMQLAEQFKQKALGLLQTATKQAEAAAPVVESKWRALEVFWAKHMWNFISGIQYLAGLSTLPGNPAIASLMAFTASITSPLTTQNTLLFNILGGWVAAQLAPPSAASAFVGAGIAGAAVGSIGLGKVLVDILAGYGAGVAGALVAFKVMSGEMPSTEDLVNLLPAILSPGALVVGVVCAAILRRHVGPGEGAVQWMNRLIAFASRGNHVSPTHYVPESDAAARVTQILSSLTITQLLKRLHQWINEDCSTPCSGSWLKDVWDWICTVLSDFKTWLQSKLLPRLPGLPFLSCQRGYKGVWRGDGIMQTTCPCGAQITGHVKNGSMRIVGPKTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPVCKPLLREEVVFQVGLNQYLVGSQLPCEPEPDVAVLTSMLTDPSHITAETAKRRLARGSPPSLASSSASQLSAPSLKATCTTHHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFDPIRAVEDEREISVPAEILRKPRKFPPALPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPSTKAPPIPPPRRKRTVVLTESTVSSALAELATKTFGSSGSSAVDSGTATGPPDQASDDGDKGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSGEAGEDVVCCSMSYTWTGALITPCAAEESKLPINPLSNSLLRHHSMVYSTTSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKARLLSIEEACKLTPPHSAKSKFGYGAKDVRSLSSRAVNHIRSVWEDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQAVMGPSYGFQYSPGQRVEFLVNTWKSKKCPMGFSYDTRCFDSTVTENDIRTEESIYQCCDLAPEARQAIRSLTERLYVGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKATAACRAAKLQDCTMLVNGDDLVVICESAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETVRHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRAKLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASQLDLSGWFVAGYNGGDIYHSLSRARPRWFMLCLLLLSVGVGIYLLPNR", "length": 3010, "header": "sp|P26662-1|POLG_HCVJA Isoform 1 of Genome polyprotein OS=Hepatitis C virus (isolate Japanese) OX=11116 GN= PE=1 SV=3 CANONICAL=P26662-1" }, "isoforms": [ { "isoform_ac": "P26662-1", "url": "https://www.uniprot.org/uniprotkb/P26662/entry#P26662-1", "sequence": { "sequence": "MSTNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARRPEGRTWAQPGYPWPLYGNEGMGWAGWLLSPRGSRPSWGPTDPRRRSRNLGKVIDTLTCGFADLMGYIPLVGAPLGGAARALAHGVRVLEDGVNYATGNLPGCSFSIFLLALLSCLTIPASAYEVRNVSGIYHVTNDCSNSSIVYEAADMIMHTPGCVPCVRESNFSRCWVALTPTLAARNSSIPTTTIRRHVDLLVGAAALCSAMYVGDLCGSVFLVSQLFTFSPRRYETVQDCNCSIYPGHVSGHRMAWDMMMNWSPTTALVVSQLLRIPQAVVDMVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDGHTHVTGGRVASSTQSLVSWLSQGPSQKIQLVNTNGSWHINRTALNCNDSLQTGFIAALFYAHRFNASGCPERMASCRPIDEFAQGWGPITHDMPESSDQRPYCWHYAPRPCGIVPASQVCGPVYCFTPSPVVVGTTDRFGAPTYSWGENETDVLLLSNTRPPQGNWFGCTWMNSTGFTKTCGGPPCNIGGVGNNTLVCPTDCFRKHPEATYTKCGSGPWLTPRCMVDYPYRLWHYPCTVNFTVFKVRMYVGGVEHRLNAACNWTRGERCDLEDRDRSELSPLLLSTTEWQILPCSFTTLPALSTGLIHLHRNIVDVQYLYGIGSAVVSFAIKWEYILLLFLLLADARVCACLWMMLLIAQAEATLENLVVLNAASVAGAHGLLSFLVFFCAAWYIKGRLVPGAAYALYGVWPLLLLLLALPPRAYAMDREMAASCGGAVFVGLVLLTLSPYYKVFLARLIWWLQYFITRAEAHLQVWVPPLNVRGGRDAIILLTCAVHPELIFDITKLLLAILGPLMVLQAGITRVPYFVRAQGLIRACMLVRKVAGGHYVQMAFMKLAALTGTYVYDHLTPLRDWAHAGLRDLAVAVEPVVFSDMETKLITWGADTAACGDIISGLPVSARRGKEILLGPADSFGEQGWRLLAPITAYSQQTRGLLGCIITSLTGRDKNQVDGEVQVLSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWPAPPGARSMTPCTCGSSDLYLVTRHADVVPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPSGHVVGIFRAAVCTRGVAKAVDFIPVESMETTMRSPVFTDNSSPPAVPQTFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIEPNIRTGVRTITTGGPITYSTYCKFLADGGCSGGAYDIIICDECHSTDSTTILGIGTVLDQAETAGARLVVLATATPPGSITVPHPNIEEVALSNTGEIPFYGKAIPIEAIKGGRHLIFCHSKKKCDELAAKLTGLGLNAVAYYRGLDVSVIPTSGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRAQRRGRTGRGRSGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETSVRLRAYLNTPGLPVCQDHLEFWESVFTGLTHIDAHFLSQTKQAGDNLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEVTLTHPITKYIMACMSADLEVVTSTWVLVGGVLAALAAYCLTTGSVVIVGRIILSGRPAVIPDREVLYQEFDEMEECASHLPYIEQGMQLAEQFKQKALGLLQTATKQAEAAAPVVESKWRALEVFWAKHMWNFISGIQYLAGLSTLPGNPAIASLMAFTASITSPLTTQNTLLFNILGGWVAAQLAPPSAASAFVGAGIAGAAVGSIGLGKVLVDILAGYGAGVAGALVAFKVMSGEMPSTEDLVNLLPAILSPGALVVGVVCAAILRRHVGPGEGAVQWMNRLIAFASRGNHVSPTHYVPESDAAARVTQILSSLTITQLLKRLHQWINEDCSTPCSGSWLKDVWDWICTVLSDFKTWLQSKLLPRLPGLPFLSCQRGYKGVWRGDGIMQTTCPCGAQITGHVKNGSMRIVGPKTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPVCKPLLREEVVFQVGLNQYLVGSQLPCEPEPDVAVLTSMLTDPSHITAETAKRRLARGSPPSLASSSASQLSAPSLKATCTTHHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFDPIRAVEDEREISVPAEILRKPRKFPPALPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPSTKAPPIPPPRRKRTVVLTESTVSSALAELATKTFGSSGSSAVDSGTATGPPDQASDDGDKGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSGEAGEDVVCCSMSYTWTGALITPCAAEESKLPINPLSNSLLRHHSMVYSTTSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKARLLSIEEACKLTPPHSAKSKFGYGAKDVRSLSSRAVNHIRSVWEDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQAVMGPSYGFQYSPGQRVEFLVNTWKSKKCPMGFSYDTRCFDSTVTENDIRTEESIYQCCDLAPEARQAIRSLTERLYVGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKATAACRAAKLQDCTMLVNGDDLVVICESAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETVRHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRAKLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASQLDLSGWFVAGYNGGDIYHSLSRARPRWFMLCLLLLSVGVGIYLLPNR", "length": 3010, "header": "sp|P26662-1|POLG_HCVJA Isoform 1 of Genome polyprotein OS=Hepatitis C virus (isolate Japanese) OX=11116 GN= PE=1 SV=3 CANONICAL=P26662-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 110, "start_aa": "Thr", "end_pos": 110, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr110", "evidence": [ { "id": "GLY_001155", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001155" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", 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Med. Chem.", "date": "2004", "authors": "Ontoria Jesus M, Di Marco Stefania, Conte Immacolata, Di Francesco M Emilia, Gardelli Cristina, Koch Uwe, Matassa Victor G, Poma Marco, Steink\u00fchler Christian, Volpari Cinzia, Harper Steven", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "reference": [ { "type": "PubMed", "id": "15588076", "url": "https://glygen.org/publication/PubMed/15588076" } ] }, { "title": "Molecular determinants for subcellular localization of hepatitis C virus core protein.", "journal": "J. Virol.", "date": "2005", "authors": "Suzuki Ryosuke, Sakamoto Shinichiro, Tsutsumi Takeya, Rikimaru Akiko, Tanaka Keiko, Shimoike Takashi, Moriishi Kohji, Iwasaki Takuya, Mizumoto Kiyohisa, Matsuura Yoshiharu, Miyamura Tatsuo, Suzuki Tetsuro", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "reference": [ { "type": "PubMed", "id": "15613354", "url": "https://glygen.org/publication/PubMed/15613354" } ] }, { "title": "Hepatitis C virus core protein acts as a trans-modulating factor on internal translation initiation of the viral RNA.", "journal": "The Journal of biological chemistry", "date": "2005-05-06", "authors": "Boni S\u00e9bastien, Lavergne Jean-Pierre, Boulant Steeve, Cahour Annie", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "reference": [ { "type": "PubMed", "id": "15760888", "url": "https://glygen.org/publication/PubMed/15760888" } ] }, { "title": "Hepatitis C virus expression suppresses interferon signaling by degrading STAT1.", "journal": "Gastroenterology", "date": "2005-04", "authors": "Lin Wenyu, Choe Won Hyeok, Hiasa Yoichi, Kamegaya Yoshitaka, Blackard Jason T, Schmidt Emmett V, Chung Raymond T", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "reference": [ { "type": "PubMed", "id": "15825084", "url": "https://glygen.org/publication/PubMed/15825084" } ] }, { "title": "Hepatitis C virus nonstructural protein 5A (NS5A) is an RNA-binding protein.", "journal": "The Journal of biological chemistry", "date": "2005-10-28", "authors": "Huang Luyun, Hwang Jungwook, Sharma Suresh D, Hargittai Michele R S, Chen Yingfeng, Arnold Jamie J, Raney Kevin D, Cameron Craig E", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "reference": [ { "type": "PubMed", "id": "16126720", "url": 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Virol.", "date": "1998", "authors": "Pawlotsky J M, Germanidis G, Neumann A U, Pellerin M, Frainais P O, Dhumeaux D", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "reference": [ { "type": "PubMed", "id": "9525599", "url": "https://glygen.org/publication/PubMed/9525599" } ] }, { "title": "The native form and maturation process of hepatitis C virus core protein.", "journal": "Journal of virology", "date": "1998", "authors": "Yasui K, Wakita T, Tsukiyama-Kohara K, Funahashi SI, Ichikawa M, Kajita T, Moradpour D, Wands JR, Kohara M", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "reference": [ { "type": "PubMed", "id": "9621068", "url": "https://glygen.org/publication/PubMed/9621068" } ] }, { "title": "Hepatitis C virus variants circumventing cytotoxic T lymphocyte activity as a mechanism of chronicity.", "journal": "Gastroenterology", "date": "1998-10", "authors": "Tsai S L, Chen Y M, Chen M H, Huang C Y, Sheen I S, Yeh C T, Huang J H, Kuo G C, Liaw Y F", "evidence": [ { "database": "IEDB", "id": "59569", "url": "https://www.iedb.org/epitope/59569" } ], "reference": [ { "type": "PubMed", "id": "9753499", "url": "https://glygen.org/publication/PubMed/9753499" } ] } ], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "P27958-1", "protein_name": "Genome polyprotein", "gene_name": "", "tax_id": 63746, "organism": "Hepatitis C virus (isolate H77)", "sequence": { "sequence": "MSTNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARRPEGRTWAQPGYPWPLYGNEGCGWAGWLLSPRGSRPSWGPTDPRRRSRNLGKVIDTLTCGFADLMGYIPLVGAPLGGAARALAHGVRVLEDGVNYATGNLPGCSFSIFLLALLSCLTVPASAYQVRNSSGLYHVTNDCPNSSVVYEAADAILHTPGCVPCVREGNASRCWVAVTPTVATRDGKLPTTQLRRHIDLLVGSATLCSALYVGDLCGSVFLVGQLFTFSPRHHWTTQDCNCSIYPGHITGHRMAWNMMMNWSPTAALVVAQLLRIPQAIMDMIAGAHWGVLAGIKYFSMVGNWAKVLVVLLLFAGVDAETHVTGGNAGRTTAGLVGLLTPGAKQNIQLINTNGSWHINSTALNCNESLNTGWLAGLFYQHKFNSSGCPERLASCRRLTDFAQGWGPISYANGSGLDERPYCWHYPPRPCGIVPAKSVCGPVYCFTPSPVVVGTTDRSGAPTYSWGANDTDVFVLNNTRPPLGNWFGCTWMNSTGFTKVCGAPPCVIGGVGNNTLLCPTDCFRKYPEATYSRCGSGPRITPRCMVDYPYRLWHYPCTINYTIFKVRMYVGGVEHRLEAACNWTRGERCDLEDRDRSELSPLLLSTTQWQVLPCSFTTLPALSTGLIHLHQNIVDVQYLYGVGSSIASWAIKWEYVVLLFLLLADARVCSCLWMMLLISQAEAALENLVILNAASLAGTHGLVSFLVFFCFAWYLKGRWVPGAVYALYGMWPLLLLLLALPQRAYALDTEVAASCGGVVLVGLMALTLSPYYKRYISWCMWWLQYFLTRVEAQLHVWVPPLNVRGGRDAVILLTCVVHPALVFDITKLLLAIFGPLWILQASLLKVPYFVRVQGLLRICALARKIAGGHYVQMAIIKLGALTGTCVYNHLAPLRDWAHNGLRDLAVAVEPVVFSRMETKLITWGADTAACGDIINGLPVSARRGQEILLGPADGMVSKGWRLLAPITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQTYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPTGHAVGLFRAAVCTRGVAKAVDFIPVENLETTMRSPVFTDNSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAKGYKVLVLNPSVAATLGFGAYMSKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADAGCSGGAYDIIICDECHSTDATSISGIGTVLDQAETAGARLVVLATATPPGSVTVSHPNIEEVALSTTGEIPFYGKAIPLEVIKGGRHLIFCHSKKKCDELAAKLVALGINAVAYYRGLDVSVIPTSGDVVVVSTDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLGFWEGVFTGLTHIDAHFLSQTKQSGENFPYLVAYQATVCARAQAPPPSWDQMRKCLIRLKPTLHGPTPLLYRLGAVQNEVTLTHPITKYIMTCMSADLEVVTSTWVLVGGVLAALAAYCLSTGCVVIVGRIVLSGKPAIIPDREVLYQEFDEMEECSQHLPYIEQGMMLAEQFKQKALGLLQTASRHAEVITPAVQTNWQKLEVFWAKHMWNFISGIQYLAGLSTLPGNPAIASLMAFTAAVTSPLTTGQTLLFNILGGWVAAQLAAPGAATAFVGAGLAGAALDSVGLGKVLVDILAGYGAGVAGALVAFKIMSGEVPSTEDLVNLLPAILSPGALAVGVVFASILRRRVGPGEGAVQWMNRLIAFASRGNHVSPTHYVPESDAAARVTAILSSLTVTQLLRRLHQWISSECTTPCSGSWLRDIWDWICEVLSDFKTWLKAKLMPQLPGIPFVSCQRGYRGVWRGDGIMHTRCHCGAEITGHVKNGTMRIVGPRTCKNMWSGTFFINAYTTGPCTPLPAPNYKFALWRVSAEEYVEIRRVGDFHYVSGMTTDNLKCPCQIPSPEFFTELDGVRLHRFAPPCKPLLREEVSFRVGLHEYPVGSQLPCEPEPDVAVLTSMLTDPSHITAEAAGRRLARGSPPSMASSSASQLSAPSLKATCTANHDSPDAELIEANLLWRQEMGGNITRVESENKVVILDSFDPLVAEEDEREVSVPAEILRKSRRFAPALPVWARPDYNPLLVETWKKPDYEPPVVHGCPLPPPRSPPVPPPRKKRTVVLTESTLPTALAELATKSFGSSSTSGITGDNTTTSSEPAPSGCPPDSDVESYSSMPPLEGEPGDPDLSDGSWSTVSSGADTEDVVCCSMSYSWTGALVTPCAAEEQKLPINALSNSLLRHHNLVYSTTSRSACQRKKKVTFDRLQVLDSHYQDVLKEVKAAASKVKANLLSVEEACSLAPPHSAKSKFGYGAKDVRCHARKAVAHINSVWKDLLEDSVTPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSKLPLAVMGSSYGFQYSPGQRVEFLVQAWKSKKTPMGLSYDTRCFDSTVTESDIRTEEAIYQCCDLDPQARVAIKSLTERLYVGGPLTNSRGENCGYRRCRASRVLTTSCGNTLTRYIKARAACRAAGLQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWARMILMTHFFSVLIARDQLEQALNCEIYGACYSIEPLDLPPIIQRLHGLSAFSLHSYSPGEINRVAACLRKLGVPPLRAWRHRAWSVRARLLARGGKAAICGKYLFNWAVRTKLKLTPITAAGRLDLSGWFTAGYSGGDIYHSVSHARPRWFWFCLLLLAAGVGIYLLPNR", "length": 3011 }, "evidence": [ { "id": "GLY_000258", "url": "https://data.glygen.org/GLY_000258", "database": "GlyGen" } ], "glygen_name": "HCV-H77", "common_name": "HCV" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 11, "go_terms": [ { "name": "host cell nucleus", "id": "GO:0042025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042025", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "viral envelope", "id": "GO:0019031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019031", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "protein-DNA complex", "id": "GO:0032993", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032993", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "viral nucleocapsid", "id": "GO:0019013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019013", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "host cell perinuclear region of cytoplasm", "id": "GO:0044220", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044220", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "virion membrane", "id": "GO:0055036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055036", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "host cell plasma membrane", "id": "GO:0020002", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020002", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "host cell endoplasmic reticulum membrane", "id": "GO:0044167", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044167", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "host cell lipid droplet", "id": "GO:0044186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044186", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "host cell mitochondrial membrane", "id": "GO:0044191", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044191", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 14, "go_terms": [ { "name": "RNA-directed RNA polymerase activity", "id": "GO:0003968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003968", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "channel activity", "id": "GO:0015267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015267", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "cysteine-type endopeptidase activity", "id": "GO:0004197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004197", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "RNA strand annealing activity", "id": "GO:0033592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033592", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "RNA helicase activity", "id": "GO:0003724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003724", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "DNA/DNA annealing activity", "id": "GO:1990814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990814", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "RNA folding chaperone", "id": "GO:0140691", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140691", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 15, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "monoatomic ion transmembrane transport", "id": "GO:0034220", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034220", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "symbiont-mediated transformation of host cell", "id": "GO:0019087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019087", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "symbiont-mediated suppression of host type I interferon-mediated signaling pathway", "id": "GO:0039502", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0039502", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity", "id": "GO:0039563", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0039563", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "symbiont-mediated activation of host autophagy", "id": "GO:0039520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0039520", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "viral RNA genome replication", "id": "GO:0039694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0039694", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "virion attachment to host cell", "id": "GO:0019062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019062", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "RNA stabilization", "id": "GO:0043489", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043489", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity", "id": "GO:0039545", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0039545", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint", "id": "GO:0039645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0039645", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "fusion of virus membrane with host endosome membrane", "id": "GO:0039654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0039654", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "clathrin-dependent endocytosis of virus by host cell", "id": "GO:0075512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0075512", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" }, { "name": "symbiont-mediated suppression of host TRAF-mediated signal transduction", "id": "GO:0039527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0039527", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1213, "end_pos": 1215, "annotation": "n_glycosylation_sequon" }, { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2041, "end_pos": 2043, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2077, "end_pos": 2079, "annotation": "n_glycosylation_sequon" }, { "start_pos": 209, "end_pos": 211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2240, "end_pos": 2242, "annotation": "n_glycosylation_sequon" }, { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" }, { "start_pos": 250, "end_pos": 252, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2788, "end_pos": 2790, "annotation": "n_glycosylation_sequon" }, { "start_pos": 305, "end_pos": 307, "annotation": "n_glycosylation_sequon" }, { "start_pos": 325, "end_pos": 327, "annotation": "n_glycosylation_sequon" }, { "start_pos": 417, "end_pos": 419, "annotation": "n_glycosylation_sequon" }, { "start_pos": 423, "end_pos": 425, "annotation": "n_glycosylation_sequon" }, { "start_pos": 430, "end_pos": 432, "annotation": "n_glycosylation_sequon" }, { "start_pos": 448, "end_pos": 450, "annotation": "n_glycosylation_sequon" }, { "start_pos": 532, "end_pos": 534, "annotation": "n_glycosylation_sequon" }, { "start_pos": 556, "end_pos": 558, "annotation": "n_glycosylation_sequon" }, { "start_pos": 576, "end_pos": 578, "annotation": "n_glycosylation_sequon" }, { "start_pos": 623, "end_pos": 625, "annotation": "n_glycosylation_sequon" }, { "start_pos": 645, "end_pos": 647, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Cleaved by host caspases which are probably activated by the viral infection.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "10793006", "url": "https://glygen.org/publication/PubMed/10793006" }, { "database": "PubMed", "id": "16517592", "url": "https://glygen.org/publication/PubMed/16517592" } ] }, { "annotation": "Phosphorylated on serines in a basal form termed p56 (PubMed:7769656, PubMed:7999043). p58 is a hyperphosphorylated form of p56 (PubMed:7769656, PubMed:7999043). p56 and p58 coexist in the cell in roughly equivalent amounts (PubMed:7999043). Hyperphosphorylation is dependent on the presence of NS4A (PubMed:7999043). Host CSNK1A1/CKI-alpha or RPS6KB1 kinases may be responsible for NS5A phosphorylation (By similarity). Phosphorylated NS5A is involved in viral replication (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "7999043", "url": "https://glygen.org/publication/PubMed/7999043" }, { "database": "PubMed", "id": "7769656", "url": "https://glygen.org/publication/PubMed/7769656" } ] }, { "annotation": "Specific enzymatic cleavages in vivo yield mature proteins (By similarity). The structural proteins, core, E1, E2 and p7 are produced by proteolytic processing by host signal peptidases (By similarity). The core protein is synthesized as a 23 kDa precursor which is retained in the ER membrane through the hydrophobic signal peptide (PubMed:15163730, PubMed:9621068). Cleavage by the signal peptidase releases the 21 kDa mature core protein (PubMed:15163730, PubMed:9621068). The cleavage of the core protein precursor occurs between aminoacids 176 and 188 but the exact cleavage site is not known (By similarity). Some degraded forms of the core protein appear as well during the course of infection (By similarity). The other proteins (p7, NS2, NS3, NS4A, NS4B, NS5A and NS5B) are cleaved by the viral proteases (PubMed:8389908). Autoprocessing between NS2 and NS3 is mediated by the NS2 cysteine protease catalytic domain and regulated by the NS3 N-terminal domain (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "8389908", "url": "https://glygen.org/publication/PubMed/8389908" }, { "database": "PubMed", "id": "15163730", "url": "https://glygen.org/publication/PubMed/15163730" }, { "database": "PubMed", "id": "9621068", "url": "https://glygen.org/publication/PubMed/9621068" } ] }, { "annotation": "The N-terminus is phosphorylated by host PRK2/PKN2.", "evidence": [ { "database": "UniProtKB", "id": "P26662", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "database": "PubMed", "id": "25031343", "url": "https://glygen.org/publication/PubMed/25031343" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "DECH box", "eco_id": "ECO_0000250", "start_pos": 1316, "end_pos": 1319, "start_aa": "Asp", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "id": "PRU00541", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00541" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Helicase ATP-binding", "eco_id": "ECO_0000255", "start_pos": 1217, "end_pos": 1369, "start_aa": "Pro", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "P26662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26662" }, { "id": "23468497", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23468497" }, { "id": "10793006", "database": "PubMed", 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