[ { "uniprot_canonical_ac": "P16112-1", "uniprot_ac": "P16112", "uniprot_id": "PGCA_HUMAN", "mass": { "chemical_mass": 261329.0, "monoisotopic_mass": 261329.0 }, "refseq": { "ac": "NP_037359", "name": "aggrecan core protein isoform 2 precursor", "summary": "This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037359" }, "gene_names": [ { "name": "ACAN", "type": "recommended", "evidence": [ { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112" } ] }, { "name": "ACAN", "type": "synonym", "evidence": [ { "id": "NP_037359", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037359" } ] }, { "name": "AGC1", "type": "synonym", "evidence": [ { "id": "NP_037359", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037359" }, { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112" } ] }, { "name": "AGCAN", "type": "synonym", "evidence": [ { "id": "NP_037359", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037359" } ] }, { "name": "CSPG1", "type": "synonym", "evidence": [ { "id": "NP_037359", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037359" }, { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112" } ] }, { "name": "CSPGCP", "type": "synonym", "evidence": [ { "id": "NP_037359", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037359" } ] }, { "name": "MSK16", "type": "synonym", "evidence": [ { "id": "NP_037359", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037359" }, { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112" } ] }, { "name": "SEDK", "type": "synonym", "evidence": [ { "id": "NP_037359", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037359" } ] }, { "name": "SSOAOD", "type": "synonym", "evidence": [ { "id": "NP_037359", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037359" } ] } ], "protein_names": [ { "name": "Aggrecan core protein", "type": "recommended", "evidence": [ { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112/entry#names_and_taxonomy" } ] }, { "name": "CSPCP", "type": "synonym", "evidence": [ { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112/entry#names_and_taxonomy" } ] }, { "name": "Cartilage-specific proteoglycan core protein", "type": "synonym", "evidence": [ { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112/entry#names_and_taxonomy" } ] }, { "name": "Chondroitin sulfate proteoglycan 1", "type": "synonym", "evidence": [ { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112/entry#names_and_taxonomy" } ] }, { "name": "Chondroitin sulfate proteoglycan core protein 1", "type": "synonym", "evidence": [ { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112/entry#names_and_taxonomy" } ] }, { "name": "aggrecan core protein isoform 2 precursor", "type": "synonym", "evidence": [ { "id": "NP_037359", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037359" } ] }, { "name": "aggrecan core protein", "type": "synonym", "evidence": [ { "id": "NP_037359", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037359" } ] }, { "name": "cartilage-specific proteoglycan core protein", "type": "synonym", "evidence": [ { "id": "NP_037359", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037359" } ] }, { "name": "chondroitin sulfate proteoglycan core protein 1", "type": "synonym", "evidence": [ { "id": "NP_037359", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037359" } ] }, { "name": "large aggregating proteoglycan", "type": "synonym", "evidence": [ { "id": "NP_037359", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037359" } ] } ], "function": [ { "annotation": "Brachyury positively regulates extracellular matrix synthesis via directly promoting aggrecan transcription in nucleus pulposus.", "evidence": [ { "database": "RefSeq", "id": "NP_037359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037359" }, { "database": "PubMed", "id": "37227215", "url": "https://glygen.org/publication/PubMed/37227215" } ] }, { "annotation": "Downregulation of ACAN is Associated with the Growth hormone pathway and Induces short stature.", "evidence": [ { "database": "RefSeq", "id": "NP_037359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037359" }, { "database": "PubMed", "id": "36597844", "url": "https://glygen.org/publication/PubMed/36597844" } ] }, { "annotation": "Genotype and phenotype in patients with ACAN gene variants: Three cases and literature review. Review article", "evidence": [ { "database": "RefSeq", "id": "NP_037359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037359" }, { "database": "PubMed", "id": "38613222", "url": "https://glygen.org/publication/PubMed/38613222" } ] }, { "annotation": "Novel missense ACAN gene variants linked to familial osteochondritis dissecans cluster in the C-terminal globular domain of aggrecan. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_037359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037359" }, { "database": "PubMed", "id": "35338222", "url": "https://glygen.org/publication/PubMed/35338222" } ] }, { "annotation": "This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_037359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037359" } ] }, { "annotation": "This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.", "evidence": [ { "database": "UniProtKB", "id": "P16112", "url": "https://www.uniprot.org/uniprotkb/P16112#function" } ] }, { "annotation": "[Analysis of a Chinese pedigree affected with familial short stature due to 15q25.3q26.1 deletion involving the ACAN gene].", "evidence": [ { "database": "RefSeq", "id": "NP_037359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037359" }, { "database": "PubMed", "id": "36972946", "url": "https://glygen.org/publication/PubMed/36972946" } ] } ], "disease": [ { "disease_id": "DOID:0051061", "recommended_name": { "id": "DOID:0051061", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0051061", "name": "stroke", "description": "A cerebrovascular disease that is characterized by disruption of blood flow to the brain resulting in damage to brain cells due to a lack of oxygen." }, "synonyms": [], "unlinked_id_list": [], "evidence": [ { "id": "0051061", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0051061" } ] }, { "disease_id": "DOID:0112282", "recommended_name": { "id": "DOID:0112282", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0112282", "name": "spondyloepiphyseal dysplasia Kimberley type", "description": "A spondyloepiphyseal dysplasia that has_material_basis_in heterozygous mutation in the ACAN gene on chromosome 15q26.1." }, "synonyms": [ { "id": "DOID:0112282", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:0112282", "name": "SEDK", "description": "" }, { "id": "MONDO:0012019", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012019", "name": "spondyloepiphyseal dysplasia, Kimberley type", "description": "A spondyloepiphyseal dysplasia caused by a single allele variation in ACAN gene, characterized by short stature and premature degenerative arthropathy." }, { "id": "MONDO:0012019", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012019", "name": "spondyloepiphyseal dysplasia, Kimberley type", "description": "" }, { "id": "MONDO:0012019", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012019", "name": "SEDK", "description": "" }, { "id": "MIM:608361", "resource": "MIM", "url": "https://www.omim.org/entry/608361", "name": "Spondyloepiphyseal dysplasia type Kimberley", "description": "Spondyloepiphyseal dysplasia type Kimberley" } ], "unlinked_id_list": [], "evidence": [ { "id": "608361", "database": "MIM", "url": "https://www.omim.org/entry/608361" }, { "id": "0112282", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0112282" } ] }, { "disease_id": "DOID:1824", "recommended_name": { "id": "DOID:1824", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1824", "name": "status epilepticus", "description": "" }, "synonyms": [ { "id": "DOID:1824", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1824", "name": "Grand mal status", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "1824", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1824" } ] }, { "disease_id": "DOID:2377", "recommended_name": { "id": "DOID:2377", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2377", "name": "multiple sclerosis", "description": "A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring." }, "synonyms": [ { "id": "DOID:2377", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2377", "name": "Generalized multiple sclerosis", "description": "" }, { "id": "DOID:2377", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:2377", "name": "insular sclerosis", "description": "" }, { "id": "MONDO:0012956", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012956", "name": "multiple sclerosis, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012956", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012956", "name": "MS2", "description": "" }, { "id": "MONDO:0012956", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012956", "name": "multiple sclerosis, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012957", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012957", "name": "multiple sclerosis, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012957", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012957", "name": "MS3", "description": "" }, { "id": "MONDO:0012957", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012957", "name": "multiple sclerosis, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012958", "name": "multiple sclerosis, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012958", "name": "MS4", "description": "" }, { "id": "MONDO:0012958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012958", "name": "multiple sclerosis, susceptibility to, 4", "description": "" }, { "id": "MIM:612595", "resource": "MIM", "url": "https://www.omim.org/entry/612595", "name": "Multiple sclerosis 3", "description": "Multiple sclerosis 3" } ], "unlinked_id_list": [], "evidence": [ { "id": "2377", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2377" } ] }, { "disease_id": "DOID:4480", "recommended_name": { "id": "DOID:4480", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4480", "name": "achondroplasia", "description": "An osteochondrodysplasia that is characterized by short stature caused by rhizomelic shortening of the limbs, characteristic facies with frontal bossing and midface hypoplasia, exaggerated lumbar lordosis, limitation of elbow extension, genu varum, and trident hand and that has_material_basis_in heterozygous mutation in the fibroblast growth factor receptor-3 gene (FGFR3) on chromosome 4p16.3. Achondroplasia results in dwarfism due to the abnormal ossification of cartilage in the long bone." }, "synonyms": [ { "id": "DOID:4480", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4480", "name": "Achondroplastic physique", "description": "" }, { "id": "DOID:4480", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4480", "name": "Chondrodystrophia", "description": "" }, { "id": "DOID:4480", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:4480", "name": "osteosclerosis congenita", "description": "" }, { "id": "MONDO:0007037", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007037", "name": "achondroplasia", "description": "Achondroplasia is the most common form of chondrodysplasia, characterized by rhizomelia, exaggerated lumbar lordosis, brachydactyly, and macrocephaly with frontal bossing and midface hypoplasia." }, { "id": "MONDO:0007037", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007037", "name": "ACH", "description": "" }, { "id": "MONDO:0007037", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007037", "name": "achondroplasia", "description": "" }, { "id": "MONDO:0007037", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007037", "name": "achondroplastic dwarfism", "description": "" }, { "id": "MIM:100800", "resource": "MIM", "url": "https://www.omim.org/entry/100800", "name": "Achondroplasia", "description": "Achondroplasia" } ], "unlinked_id_list": [], "evidence": [ { "id": "4480", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4480" } ] }, { "disease_id": "DOID:6000", "recommended_name": { "id": "DOID:6000", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:6000", "name": "congestive heart failure", "description": "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body." }, "synonyms": [ { "id": "DOID:6000", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:6000", "name": "CHF", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:6000", "name": "Cardiac Failure Congestive", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:6000", "name": "Congestive heart disease", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:6000", "name": "Weak heart", "description": "" } ], "unlinked_id_list": [ "DOID:12326" ], "evidence": [ { "id": "6000", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6000" } ] }, { "disease_id": "DOID:7148", "recommended_name": { "id": "DOID:7148", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:7148", "name": "rheumatoid arthritis", "description": "An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint." }, "synonyms": [ { "id": "DOID:7148", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:7148", "name": "Arthritis or polyarthritis, rheumatic", "description": "" }, { "id": "DOID:7148", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:7148", "name": "atrophic Arthritis", "description": "" }, { "id": "MONDO:0008383", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008383", "name": "rheumatoid arthritis", "description": "A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor." }, { "id": "MONDO:0008383", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008383", "name": "RA", "description": "" }, { "id": "MONDO:0008383", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008383", "name": "rheumatoid arthritis", "description": "" }, { "id": "MIM:180300", "resource": "MIM", "url": "https://www.omim.org/entry/180300", "name": "Rheumatoid arthritis", "description": "Rheumatoid arthritis" } ], "unlinked_id_list": [], "evidence": [ { "id": "7148", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:7148" } ] }, { "disease_id": "DOID:8398", "recommended_name": { "id": "DOID:8398", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:8398", "name": "osteoarthritis", "description": "An arthritis that has_material_basis_in worn out cartilage located_in joint." }, "synonyms": [ { "id": "DOID:8398", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:8398", "name": "Osteoarthrosis and allied disorder", "description": "" }, { "id": "DOID:8398", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:8398", "name": "degenerative arthritis", "description": "" }, { "id": "DOID:8398", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:8398", "name": "degenerative joint disease", "description": "" }, { "id": "DOID:8398", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:8398", "name": "hypertrophic arthritis", "description": "" }, { "id": "DOID:8398", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:8398", "name": "osteoarthrosis", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "8398", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8398" } ] }, { "disease_id": "DOID:84", "recommended_name": { "id": "DOID:84", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:84", "name": "osteochondritis dissecans", "description": "An ischemic bone disease that results_in necrosis located_in epiphysis." }, "synonyms": [ { "id": "DOID:84", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:84", "name": "OCD", "description": "" }, { "id": "MONDO:0100462", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100462", "name": "short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans", "description": "A rare genetic skeletal disorder characterized clinically by abnormal chondro-skeletal development, disproportionate short stature and skeletal deformation mainly affecting the knees, hips, ankles and elbows with onset generally in late childhood or adolescence." }, { "id": "MONDO:0100462", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100462", "name": "OD", "description": "" }, { "id": "MONDO:0100462", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100462", "name": "SSOAOD", "description": "" }, { "id": "MONDO:0100462", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100462", "name": "osteochondritis dissecans and short stature", "description": "" }, { "id": "MONDO:0100462", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100462", "name": "osteochondritis dissecans, short stature, and early-onset osteoarthritis", "description": "" }, { "id": "MIM:165800", "resource": "MIM", "url": "https://www.omim.org/entry/165800", "name": "Short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans", "description": "Short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans" } ], "unlinked_id_list": [], "evidence": [ { "id": "165800", "database": "MIM", "url": "https://www.omim.org/entry/165800" } ] }, { "disease_id": "DOID:90", "recommended_name": { "id": "DOID:90", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:90", "name": "degenerative disc disease", "description": "A bone deterioration disease that has_material_basis_in gradual dehydration and tears located_in intervertebral disc." }, "synonyms": [ { "id": "DOID:90", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:90", "name": "cervical disc degenerative disease", "description": "" }, { "id": "DOID:90", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:90", "name": "intervertebral disc degeneration", "description": "" }, { "id": "DOID:90", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:90", "name": "lumbar disc degeneration", "description": "" }, { "id": "DOID:90", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:90", "name": "vertebral disc disease", "description": "" }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "intervertebral disk degenerative disorder", "description": "Any disease of a degenerative nature that affects the intervertebral disk." }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "IDD", "description": "" }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "degenerative disk disease", "description": "" }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "degenerative disorder of intervertebral disc", "description": "" }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "degenerative disorder of intervertebral disk", "description": "" }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "intervertebral Disc Degeneration", "description": "" }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "intervertebral Disc degenerative disease", "description": "" }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "intervertebral Disc degenerative disorder", "description": "" }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "intervertebral disc degeneration", "description": "" }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "intervertebral disc disease", "description": "" }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "intervertebral disk degeneration", "description": "" }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "intervertebral disk degenerative disorder", "description": "" }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "intervertebral disk disease", "description": "" }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "vertebral Disc degenerative disease", "description": "" }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "vertebral Disc degenerative disorder", "description": "" }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "vertebral disk disease", "description": "" }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "cervical disc degenerative disease", "description": "" }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "cervical disk degenerative disease", "description": "" }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "lumbar disc degeneration", "description": "" }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "lumbar disk degeneration", "description": "" }, { "id": "MIM:603932", "resource": "MIM", "url": "https://www.omim.org/entry/603932", "name": "Intervertebral disc disease", "description": "Intervertebral disc disease" } ], "unlinked_id_list": [], "evidence": [ { "id": "90", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:90" } ] }, { "disease_id": "MONDO:0013014", "recommended_name": { "id": "MONDO:0013014", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013014", "name": "spondyloepimetaphyseal dysplasia, aggrecan type", "description": "A spondyloepimetaphyseal dysplasia caused by biallelic variation in ACAN gene, characterized by severe short stature, facial dysmorphism and characteristic radiographic findings." }, "synonyms": [ { "id": "MONDO:0013014", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013014", "name": "SEMD, aggrecan type", "description": "" }, { "id": "MONDO:0013014", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013014", "name": "spondyloepimetaphyseal dysplasia, aggrecan type", "description": "" }, { "id": "MONDO:0013014", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013014", "name": "SEMDAG", "description": "" }, { "id": "MIM:612813", "resource": "MIM", "url": "https://www.omim.org/entry/612813", "name": "Spondyloepimetaphyseal dysplasia, aggrecan type", "description": "Spondyloepimetaphyseal dysplasia, aggrecan type" } ], "unlinked_id_list": [], "evidence": [ { "id": "612813", "database": "MIM", "url": "https://www.omim.org/entry/612813" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "69.82", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000157766", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157766" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "66.7", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000157766", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157766" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "56.39", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000157766", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157766" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "83.98", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000157766", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157766" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "61.93", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000157766", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157766" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "60.45", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000157766", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157766" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "66.65", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000157766", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157766" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "57.49", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000157766", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157766" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "61.54", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000157766", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157766" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "65.96", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000157766", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157766" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "39.18", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000157766", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157766" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "59.15", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000157766", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157766" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "52.51", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000157766", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157766" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P16112", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P16112" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0700275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700275", "name": "prostate cancer, hereditary", "description": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents." }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:610997", "resource": "MIM", "url": "https://www.omim.org/entry/610997", "name": "Prostate cancer, hereditary, 9", "description": "Prostate cancer, hereditary, 9" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P16112", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P16112" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "GC", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" }, { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "P16112", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P16112" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ], "unlinked_id_list": [], "evidence": [ { "id": "11054", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Head and neck cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "P16112", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P16112" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ], "unlinked_id_list": [ "DOID:1542" ], "evidence": [ { "id": "11934", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11934" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "https://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "P16112", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P16112" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", 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"categories": [ "Glycoproteomics" ] }, { "id": "PR:P16112", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:P16112", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-1474228", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1474228", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-HSA-2022854", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2022854", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-HSA-2022857", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2022857", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-HSA-3656225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3656225", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-HSA-3656243", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3656243", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-HSA-3656244", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3656244", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_037359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037359", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "GLY_000040", "url": "http://data.glygen.org/GLY_000040", "database": "UniCarbKB", "categories": [] }, { "id": "A0A5K1VW97", "url": "https://www.uniprot.org/uniprotkb/A0A5K1VW97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A5K1VW97-1", "url": "https://www.uniprot.org/uniprotkb/A0A5K1VW97-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YK70", "url": "https://www.uniprot.org/uniprotkb/H0YK70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YK70-1", "url": "https://www.uniprot.org/uniprotkb/H0YK70-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P16112", "url": "https://www.uniprot.org/uniprotkb/P16112", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P16112-1", "url": "https://www.uniprot.org/uniprotkb/P16112-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P16112-2", "url": "https://www.uniprot.org/uniprotkb/P16112-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P16112-3", "url": "https://www.uniprot.org/uniprotkb/P16112-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P16112-4", "url": "https://www.uniprot.org/uniprotkb/P16112-4", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTLLWVFVTLRVITAAVTVETSDHDNSLSVSIPQPSPLRVLLGTSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPSDATLEVQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITVQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLEPEEPFTFAPEIGATAFAEVENETGEATRPWGFPTPGLGPATAFTSEDLVVQVTAVPGQPHLPGGVVFHYRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALEFCESHNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGISAVPSPGEEEGGTPTSPSGVEEWIVTQVVPGVAAVPVEEETTAVPSGETTAILEFTTEPENQTEWEPAYTPVGTSPLPGILPTWPPTGAATEESTEGPSATEVPSASEEPSPSEVPFPSEEPSPSEEPFPSVRPFPSVELFPSEEPFPSKEPSPSEEPSASEEPYTPSPPVPSWTELPSSGEESGAPDVSGDFTGSGDVSGHLDFSGQLSGDRASGLPSGDLDSSGLTSTVGSGLPVESGLPSGDEERIEWPSTPTVGELPSGAEILEGSASGVGDLSGLPSGEVLETSASGVGDLSGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETTAPGVEEISGLPSGEVLETTAPGVDEISGLPSGEVLETTAPGVEEISGLPSGEVLETSTSAVGDLSGLPSGGEVLEISVSGVEDISGLPSGEVVETSASGIEDVSELPSGEGLETSASGVEDLSRLPSGEEVLEISASGFGDLSGLPSGGEGLETSASEVGTDLSGLPSGREGLETSASGAEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPETSGLPSGFSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSLVDSTLVEVVTASTASELEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGEIPGLFGVSGQPSGFPDTSGETSGVTELSGLSSGQPGISGEASGVLYGTSQPFGITDLSGETSGVPDLSGQPSGLPGFSGATSGVPDLVSGTTSGSGESSGITFVDTSLVEVAPTTFKEEEGLGSVELSGLPSGEADLSGKSGMVDVSGQFSGTVDSSGFTSQTPEFSGLPSGIAEVSGESSRAEIGSSLPSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILELSGAHSGAPDMSGEHSGFLDLSGLQSGLIEPSGEPPGTPYFSGDFASTTNVSGESSVAMGTSGEASGLPEVTLITSEFVEGVTEPTISQELGQRPPVTHTPQLFESSGKVSTAGDISGATPVLPGSGVEVSSVPESSSETSAYPEAGFGASAAPEASREDSGSPDLSETTSAFHEANLERSSGLGVSGSTLTFQEGEASAAPEVSGESTTTSDVGTEAPGLPSATPTASGDRTEISGDLSGHTSQLGVVISTSIPESEWTQQTQRPAETHLEIESSSLLYSGEETHTVETATSPTDASIPASPEWKRESESTAAAPARSCAEEPCGAGTCKETEGHVICLCPPGYTGEHCNIDQEVCEEGWNKYQGHCYRHFPDRETWVDAERRCREQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHPMQFENWRPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQKKDRYEINSLVRYQCTEGFVQRHMPTIRCQPSGHWEEPQITCTDPTTYKRRLQKRSSRHPRRSRPSTAH", "length": 2530, "header": "sp|P16112-1|PGCA_HUMAN Isoform 1 of Aggrecan core protein OS=Homo sapiens OX=9606 GN=ACAN PE=1 SV=3 CANONICAL=P16112-1" }, "isoforms": [ { "isoform_ac": "A0A5K1VW97-1", "url": "https://www.uniprot.org/uniprotkb/P16112/entry#A0A5K1VW97-1", "sequence": { "sequence": "MTTLLWVFVTLRVITAAVTVETSDHDNSLSVSIPQPSPLRVLLGTSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPSDATLEVQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITVQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLEPEEPFTFAPEIGATAFAEVENETGEATRPWGFPTPGLGPATAFTSEDLVVQVTAVPGQPHLPGGVVFHYRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALEFCESHNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGISAVPSPGEEEGGTPTSPSGVEEWIVTQVVPGVAAVPVEEETTAVPSGETTAILEFTTEPENQTEWEPAYTPVGTSPLPGILPTWPPTGAATEESTEGPSATEVPSASEEPSPSEVPFPSEEPSPSEEPFPSVRPFPSVELFPSEEPFPSKEPSPSEEPSASEEPYTPSPPVPSWTELPSSGEESGAPDVSGDFTGSGDVSGHLDFSGQLSGDRASGLPSGDLDSSGLTSTVGSGLPVESGLPSGDEERIEWPSTPTVGELPSGAEILEGSASGVGDLSGLPSGEVLETSASGVGDLSGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETTAPGVEEISGLPSGEVLETTAPGVDEISGLPSGEVLETTAPGVEEISGLPSGEVLETSTSAVGDLSGLPSGGEVLEISVSGVEDISGLPSGEVVETSASGIEDVSELPSGEGLETSASGVEDLSRLPSGEEVLEISASGFGDLSGLPSGGEGLETSASEVGTDLSGLPSGREGLETSASGAEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPETSGLPSGFSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSLVDSTLVEVVTASTASELEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGEIPGLFGVSGQPSGFPDTSGETSGVTELSGLSSGQPGISGEASGVLYGTSQPFGITDLSGETSGVPDLSGQPSGLPGFSGATSGVPDLVSGTTSGSGESSGITFVDTSLVEVAPTTFKEEEGLGSVELSGLPSGEADLSGKSGMVDVSGQFSGTVDSSGFTSQTPEFSGLPSGIAEVSGESSRAEIGSSLPSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILELSGAHSGAPDMSGEHSGFLDLSGLQSGLIEPSGEPPGTPYFSGDFASTTNVSGESSVAMGTSGEASGLPEVTLITSEFVEGVTEPTISQELGQRPPVTHTPQLFESSGKVSTAGDISGATPVLPGSGVEVSSVPESSSETSAYPEAGFGASAAPEASREDSGSPDLSETTSAFHEANLERSSGLGVSGSTLTFQEGEASAAPEVSGESTTTSDVGTEAPGLPSATPTASGDRTEISGDLSGHTSQLGVVISTSIPESEWTQQTQRPAETHLEIESSSLLYSGEETHTVETATSPTDASIPASPEWKRESESTAADIDECLSSPCLNGATCVDAIDSFTCLCLPSYEGDLCEIDQEVCEEGWNKYQGHCYRHFPDRETWVDAERRCREQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHPMQFENWRPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQKKDRYEINSLVRYQCTEGFVQRHMPTIRCQPSGHWEEPQITCTDPTTYKRRLQKRSSRHPRRSRPSTAH", "length": 2530, "header": "tr|A0A5K1VW97-1|A0A5K1VW97_HUMAN Computationally mapped isoform of Aggrecan core protein OS=Homo sapiens OX=9606 GN=ACAN PE=1 SV=2 CANONICAL=P16112-1" }, "locus": { "chromosome": "15", "start_pos": 88874478, "end_pos": 88836207, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000561243.7", "url": "https://www.ensembl.org/id/ENST00000561243.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000453342.3", "url": "https://www.ensembl.org/id/ENSP00000453342.3" } ] } }, { "isoform_ac": "H0YK70-1", "url": "https://www.uniprot.org/uniprotkb/P16112/entry#H0YK70-1", "sequence": { "sequence": "XWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQKKDRYEINSLVRYQCTEGFVQRHMPTIRCQPSGHWEEPQITCTDREHHPGHLAEHRPPPTNADYRSGAHGTLGGAAPAQPTEKSFQDAPRTLSPGACQADVHPTQTVSSSCRFLSYKESH", "length": 156, "header": "tr|H0YK70-1|H0YK70_HUMAN Computationally mapped isoform of Aggrecan OS=Homo sapiens OX=9606 GN=ACAN PE=1 SV=1 CANONICAL=P16112-1" }, "locus": { "chromosome": "15", "start_pos": 88874597, "end_pos": 88872969, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000558704.1", "url": "https://www.ensembl.org/id/ENST00000558704.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000452682.1", "url": "https://www.ensembl.org/id/ENSP00000452682.1" } ] } }, { "isoform_ac": "P16112-1", "url": "https://www.uniprot.org/uniprotkb/P16112/entry#P16112-1", "sequence": { "sequence": "MTTLLWVFVTLRVITAAVTVETSDHDNSLSVSIPQPSPLRVLLGTSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPSDATLEVQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITVQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLEPEEPFTFAPEIGATAFAEVENETGEATRPWGFPTPGLGPATAFTSEDLVVQVTAVPGQPHLPGGVVFHYRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALEFCESHNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGISAVPSPGEEEGGTPTSPSGVEEWIVTQVVPGVAAVPVEEETTAVPSGETTAILEFTTEPENQTEWEPAYTPVGTSPLPGILPTWPPTGAATEESTEGPSATEVPSASEEPSPSEVPFPSEEPSPSEEPFPSVRPFPSVELFPSEEPFPSKEPSPSEEPSASEEPYTPSPPVPSWTELPSSGEESGAPDVSGDFTGSGDVSGHLDFSGQLSGDRASGLPSGDLDSSGLTSTVGSGLPVESGLPSGDEERIEWPSTPTVGELPSGAEILEGSASGVGDLSGLPSGEVLETSASGVGDLSGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETTAPGVEEISGLPSGEVLETTAPGVDEISGLPSGEVLETTAPGVEEISGLPSGEVLETSTSAVGDLSGLPSGGEVLEISVSGVEDISGLPSGEVVETSASGIEDVSELPSGEGLETSASGVEDLSRLPSGEEVLEISASGFGDLSGLPSGGEGLETSASEVGTDLSGLPSGREGLETSASGAEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPETSGLPSGFSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSLVDSTLVEVVTASTASELEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGEIPGLFGVSGQPSGFPDTSGETSGVTELSGLSSGQPGISGEASGVLYGTSQPFGITDLSGETSGVPDLSGQPSGLPGFSGATSGVPDLVSGTTSGSGESSGITFVDTSLVEVAPTTFKEEEGLGSVELSGLPSGEADLSGKSGMVDVSGQFSGTVDSSGFTSQTPEFSGLPSGIAEVSGESSRAEIGSSLPSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILELSGAHSGAPDMSGEHSGFLDLSGLQSGLIEPSGEPPGTPYFSGDFASTTNVSGESSVAMGTSGEASGLPEVTLITSEFVEGVTEPTISQELGQRPPVTHTPQLFESSGKVSTAGDISGATPVLPGSGVEVSSVPESSSETSAYPEAGFGASAAPEASREDSGSPDLSETTSAFHEANLERSSGLGVSGSTLTFQEGEASAAPEVSGESTTTSDVGTEAPGLPSATPTASGDRTEISGDLSGHTSQLGVVISTSIPESEWTQQTQRPAETHLEIESSSLLYSGEETHTVETATSPTDASIPASPEWKRESESTAAAPARSCAEEPCGAGTCKETEGHVICLCPPGYTGEHCNIDQEVCEEGWNKYQGHCYRHFPDRETWVDAERRCREQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHPMQFENWRPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQKKDRYEINSLVRYQCTEGFVQRHMPTIRCQPSGHWEEPQITCTDPTTYKRRLQKRSSRHPRRSRPSTAH", "length": 2530, "header": "sp|P16112-1|PGCA_HUMAN Isoform 1 of Aggrecan core protein OS=Homo sapiens OX=9606 GN=ACAN PE=1 SV=3 CANONICAL=P16112-1" }, "locus": { "chromosome": "15", "start_pos": 88874478, "end_pos": 88836207, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000439576.7", "url": "https://www.ensembl.org/id/ENST00000439576.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000387356.2", "url": "https://www.ensembl.org/id/ENSP00000387356.2" } ] } }, { "isoform_ac": "P16112-2", "url": "https://www.uniprot.org/uniprotkb/P16112/entry#P16112-2", "sequence": { "sequence": "MTTLLWVFVTLRVITAAVTVETSDHDNSLSVSIPQPSPLRVLLGTSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPSDATLEVQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITVQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLEPEEPFTFAPEIGATAFAEVENETGEATRPWGFPTPGLGPATAFTSEDLVVQVTAVPGQPHLPGGVVFHYRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALEFCESHNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGISAVPSPGEEEGGTPTSPSGVEEWIVTQVVPGVAAVPVEEETTAVPSGETTAILEFTTEPENQTEWEPAYTPVGTSPLPGILPTWPPTGAATEESTEGPSATEVPSASEEPSPSEVPFPSEEPSPSEEPFPSVRPFPSVELFPSEEPFPSKEPSPSEEPSASEEPYTPSPPVPSWTELPSSGEESGAPDVSGDFTGSGDVSGHLDFSGQLSGDRASGLPSGDLDSSGLTSTVGSGLPVESGLPSGDEERIEWPSTPTVGELPSGAEILEGSASGVGDLSGLPSGEVLETSASGVGDLSGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETTAPGVEEISGLPSGEVLETTAPGVDEISGLPSGEVLETTAPGVEEISGLPSGEVLETSTSAVGDLSGLPSGGEVLEISVSGVEDISGLPSGEVVETSASGIEDVSELPSGEGLETSASGVEDLSRLPSGEEVLEISASGFGDLSGLPSGGEGLETSASEVGTDLSGLPSGREGLETSASGAEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPETSGLPSGFSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSLVDSTLVEVVTASTASELEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGEIPGLFGVSGQPSGFPDTSGETSGVTELSGLSSGQPGISGEASGVLYGTSQPFGITDLSGETSGVPDLSGQPSGLPGFSGATSGVPDLVSGTTSGSGESSGITFVDTSLVEVAPTTFKEEEGLGSVELSGLPSGEADLSGKSGMVDVSGQFSGTVDSSGFTSQTPEFSGLPSGIAEVSGESSRAEIGSSLPSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILELSGAHSGAPDMSGEHSGFLDLSGLQSGLIEPSGEPPGTPYFSGDFASTTNVSGESSVAMGTSGEASGLPEVTLITSEFVEGVTEPTISQELGQRPPVTHTPQLFESSGKVSTAGDISGATPVLPGSGVEVSSVPESSSETSAYPEAGFGASAAPEASREDSGSPDLSETTSAFHEANLERSSGLGVSGSTLTFQEGEASAAPEVSGESTTTSDVGTEAPGLPSATPTASGDRTEISGDLSGHTSQLGVVISTSIPESEWTQQTQRPAETHLEIESSSLLYSGEETHTVETATSPTDASIPASPEWKRESESTAADQEVCEEGWNKYQGHCYRHFPDRETWVDAERRCREQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHPMQFENWRPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQKKDRYEINSLVRYQCTEGFVQRHMPTIRCQPSGHWEEPQITCTDPTTYKRRLQKRSSRHPRRSRPSTAH", "length": 2492, "header": "sp|P16112-2|PGCA_HUMAN Isoform 2 of Aggrecan core protein OS=Homo sapiens OX=9606 GN=ACAN PE=1 SV=3 CANONICAL=P16112-1" }, "locus": { "chromosome": "15", "start_pos": 88874478, "end_pos": 88836207, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000559004.5", "url": "https://www.ensembl.org/id/ENST00000559004.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000453499.1", "url": "https://www.ensembl.org/id/ENSP00000453499.1" } ] } }, { "isoform_ac": "P16112-3", "url": "https://www.uniprot.org/uniprotkb/P16112/entry#P16112-3", "sequence": { "sequence": "MTTLLWVFVTLRVITAAVTVETSDHDNSLSVSIPQPSPLRVLLGTSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPSDATLEVQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITVQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLEPEEPFTFAPEIGATAFAEVENETGEATRPWGFPTPGLGPATAFTSEDLVVQVTAVPGQPHLPGGVVFHYRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALEFCESHNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGISAVPSPGEEEGGTPTSPSGVEEWIVTQVVPGVAAVPVEEETTAVPSGETTAILEFTTEPENQTEWEPAYTPVGTSPLPGILPTWPPTGAATEESTEGPSATEVPSASEEPSPSEVPFPSEEPSPSEEPFPSVRPFPSVELFPSEEPFPSKEPSPSEEPSASEEPYTPSPPVPSWTELPSSGEESGAPDVSGDFTGSGDVSGHLDFSGQLSGDRASGLPSGDLDSSGLTSTVGSGLPVESGLPSGDEERIEWPSTPTVGELPSGAEILEGSASGVGDLSGLPSGEVLETSASGVGDLSGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETTAPGVEEISGLPSGEVLETTAPGVDEISGLPSGEVLETTAPGVEEISGLPSGEVLETSTSAVGDLSGLPSGGEVLEISVSGVEDISGLPSGEVVETSASGIEDVSELPSGEGLETSASGVEDLSRLPSGEEVLEISASGFGDLSGLPSGGEGLETSASEVGTDLSGLPSGREGLETSASGAEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPETSGLPSGFSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSLVDSTLVEVVTASTASELEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGEIPGLFGVSGQPSGFPDTSGETSGVTELSGLSSGQPGISGEASGVLYGTSQPFGITDLSGETSGVPDLSGQPSGLPGFSGATSGVPDLVSGTTSGSGESSGITFVDTSLVEVAPTTFKEEEGLGSVELSGLPSGEADLSGKSGMVDVSGQFSGTVDSSGFTSQTPEFSGLPSGIAEVSGESSRAEIGSSLPSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILELSGAHSGAPDMSGEHSGFLDLSGLQSGLIEPSGEPPGTPYFSGDFASTTNVSGESSVAMGTSGEASGLPEVTLITSEFVEGVTEPTISQELGQRPPVTHTPQLFESSGKVSTAGDISGATPVLPGSGVEVSSVPESSSETSAYPEAGFGASAAPEASREDSGSPDLSETTSAFHEANLERSSGLGVSGSTLTFQEGEASAAPEVSGESTTTSDVGTEAPGLPSATPTASGDRTEISGDLSGHTSQLGVVISTSIPESEWTQQTQRPAETHLEIESSSLLYSGEETHTVETATSPTDASIPASPEWKRESESTAADQEVCEEGWNKYQGHCYRHFPDRETWVDAERRCREQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHPMQFENWRPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGTATTYKRRLQKRSSRHPRRSRPSTAH", "length": 2431, "header": "sp|P16112-3|PGCA_HUMAN Isoform 3 of Aggrecan core protein OS=Homo sapiens OX=9606 GN=ACAN PE=1 SV=3 CANONICAL=P16112-1" }, "locus": { "chromosome": "15", "start_pos": 88874478, "end_pos": 88836207, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000352105.11", "url": "https://www.ensembl.org/id/ENST00000352105.11" }, { "database": "Ensembl Peptide", "id": "ENSP00000341615.7", "url": "https://www.ensembl.org/id/ENSP00000341615.7" } ] } }, { "isoform_ac": "P16112-4", "url": "https://www.uniprot.org/uniprotkb/P16112/entry#P16112-4", "sequence": { "sequence": "MTTLLWVFVTLRVITAAVTVETSDHDNSLSVSIPQPSPLRVLLGTSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPSDATLEVQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITVQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLEPEEPFTFAPEIGATAFAEVENETGEATRPWGFPTPGLGPATAFTSEDLVVQVTAVPGQPHLPGGVVFHYRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALEFCESHNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGISAVPSPGEEEGGTPTSPSGVEEWIVTQVVPGVAAVPVEEETTAVPSGETTAILEFTTEPENQTEWEPAYTPVGTSPLPGILPTWPPTGAATEESTEGPSATEVPSASEEPSPSEVPFPSEEPSPSEEPFPSVRPFPSVELFPSEEPFPSKEPSPSEEPSASEEPYTPSPPVPSWTELPSSGEESGAPDVSGDFTGSGDVSGHLDFSGQLSGDRASGLPSGDLDSSGLTSTVGSGLPVESGLPSGDEERIEWPSTPTVGELPSGAEILEGSASGVGDLSGLPSGEVLETSASGVGDLSGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETTAPGVEEISGLPSGEVLETTAPGVDEISGLPSGEVLETTAPGVEEISGLPSGEVLETSTSAVGDLSGLPSGGEVLEISVSGVEDISGLPSGEVVETSASGIEDVSELPSGEGLETSASGVEDLSRLPSGEEVLEISASGFGDLSGLPSGGEGLETSASEVGTDLSGLPSGREGLETSASGAEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPETSGLPSGFSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSLVDSTLVEVVTASTASELEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGEIPGLFGVSGQPSGFPDTSGETSGVTELSGLSSGQPGISGEASGVLYGTSQPFGITDLSGETSGVPDLSGQPSGLPGFSGATSGVPDLVSGTTSGSGESSGITFVDTSLVEVAPTTFKEEEGLGSVELSGLPSGEADLSGKSGMVDVSGQFSGTVDSSGFTSQTPEFSGLPSGIAEVSGESSRAEIGSSLPSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILELSGAHSGAPDMSGEHSGFLDLSGLQSGLIEPSGEPPGTPYFSGDFASTTNVSGESSVAMGTSGEASGLPEVTLITSEFVEGVTEPTISQELGQRPPVTHTPQLFESSGKVSTAGDISGATPVLPGSGVEVSSVPESSSETSAYPEAGFGASAAPEASREDSGSPDLSETTSAFHEANLERSSGLGVSGSTLTFQEGEASAAPEVSGESTTTSDVGTEAPGLPSATPTASGDRTEISGDLSGHTSQLGVVISTSIPESEWTQQTQRPAETHLEIESSSLLYSGEETHTVETATSPTDASIPASPEWKRESESTAAAPARSCAEEPCGAGTCKETEGHVICLCPPGYTGEHCNIDIDECLSSPCLNGATCVDAIDSFTCLCLPSYEGDLCEIDQEVCEEGWNKYQGHCYRHFPDRETWVDAERRCREQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHPMQFENWRPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQKKDRYEINSLVRYQCTEGFVQRHMPTIRCQPSGHWEEPQITCTDPTTYKRRLQKRSSRHPRRSRPSTAH", "length": 2568, "header": "sp|P16112-4|PGCA_HUMAN Isoform 4 of Aggrecan core protein OS=Homo sapiens OX=9606 GN=ACAN PE=1 SV=3 CANONICAL=P16112-1" }, "locus": { "chromosome": "15", "start_pos": 88874478, "end_pos": 88836207, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000560601.4", "url": "https://www.ensembl.org/id/ENST00000560601.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000453581.2", "url": "https://www.ensembl.org/id/ENSP00000453581.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "start_pos": 105, "start_aa": "Ser", "end_pos": 105, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser105", "evidence": [ { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "P16112", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P16112" }, { "id": "40930100", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/40930100" }, { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "P16112", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P16112" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "T", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1080, "start_aa": "Thr", "end_pos": 1080, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1080", "evidence": [ { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" }, { "id": "GLY_000040", "database": "UniCarbKB", "url": "http://data.glygen.org/GLY_000040" } ] }, { "glytoucan_ac": "G02815KT", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "SnDSGVYR", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 126, "start_aa": "Asn", "end_pos": 126, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn126", "evidence": [ { "id": "37074911", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37074911" }, { "id": "PDC000471", "database": "PDC", "url": "https://proteomic.datacommons.cancer.gov/pdc/study/PDC000471" } ] }, { "glytoucan_ac": "G02886BB", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "SnDSGVYR", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 126, "start_aa": "Asn", 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J.", "date": "1996", "authors": "Dudhia J, Davidson C M, Wells T M, Vynios D H, Hardingham T E, Bayliss M T", "evidence": [ { "database": "UniProtKB", "id": "P16112", "url": "https://www.uniprot.org/uniprotkb/P16112" }, { "database": "HumanLectome", "id": "77", "url": "https://unilectin.unige.ch/humanLectome/HL_entryPage?idHL=77" } ], "reference": [ { "type": "PubMed", "id": "8611178", "url": "https://glygen.org/publication/PubMed/8611178" } ] }, { "title": "Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line.", "journal": "Biochemistry", "date": "1996", "authors": "Basu SS, Basu M, Li Z, Basu S", "evidence": [ { "database": "Reactome", "id": "R-HSA-2022854", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2022854" } ], "reference": [ { "type": "PubMed", "id": "8611500", "url": "https://glygen.org/publication/PubMed/8611500" } ] }, { "title": "The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Whitelock JM, Murdoch AD, Iozzo RV, Underwood PA", "evidence": [ { "database": "Reactome", "id": "R-HSA-1474228", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1474228" } ], "reference": [ { "type": "PubMed", "id": "8626565", "url": "https://glygen.org/publication/PubMed/8626565" } ] }, { "title": "Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. 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"MLSLLLLSMCLWVFSATASFDYIDTEPESPLRVSIPNELPLRPLMGDTLVLPCYFQDNTVNDPGAPTIAPLSHRIKWSLVTKEKTTNILVASEGIVSIEKRYMDRITLVGYPMTPTDASIKITELHSNDSGVYRCEVMQGIEDSHDIVDVQVQGIVFHYRAITTRYTLNFEKAKAACIQNSAVIATPEQLQAAYDEGFHQCDAGWLADQTVRYPIHDPREACYGDKYEFPGVRTYGVRDVNETYDVYCFAERMTGKVFHTTSPNKFTFEEAEAQCSKLGAKLATTGQLYLAWKGGMDVCNAGWLADRSVRYPINIARPQCGGGLLGVRTVYLFPNQTGYPHPDSRYDAFCYSETGDEGSGFFPLDLELTTDGDNGVLTVDTITESHTVISKPASTESEVQGEVVTYKPSVTTSVENPYTALDISHVLPSPPTSSVEKDPDFGSGLSQSNKTEDTMSATGVVFHYRGGNCSRYPFGFVEAQLACKSIGAVIASAQQLQAAYEAGYHQCDAGWLSDQTVRYPIVSPRHQCSGDMEQVPGVRSYGLRPADERYDVYCYVDKLRGQVFHASSFEGFTYGEAVAHCQGQNASLASTAHLYAAWKQGFDKCRAGWLLDRSVRYSINIPRQQCGGGRTGVHTVYLFPNQTGSPDLHSKFDAYCFKEDLDLPLNESESQETVTEEKIVSISSHPALHRPEGTPIIAPSPTEPSGTEESVASSSGDLLSSGSGDQPSGSSVSSGDSSGTSSTDDLLTSGSGDQSGSGSSVTSGDYSGASGTDSLFSSGSGDRSSGSFSSSGDFSGASGTDDLLGSGSGEQPSGSFVSSGDFSGASGSGDMSSGSGSSSGSGSGLDILVTFSGIDTVFSGVGSTSGQLEEAGEGSTEILTFQLDQISGSGSGLGSGSGYSSEESGSTSDLSSSSGESGESGDLSGISSGSGFSEESSGFSGFASGIFPSGGSSDISFIDGSGIIMVDRPWMKISSFLTEQELGSGQVDFSGSGLFSGSGVSGDISGLSGEISGSSGDSSGISSDISGMSGDISGMSGDISGISGDITGMSGDLSGMSSSDHSGSGSGLAFSGVTFLGSGFTDLTEQSREQEASGLVFFGSGEGSGFRSGGYAIESGERSGDSASSDVIFFSNNDMVEMSNKPLQGMELGRGEVEYSGTVRLSSGSGDDQSVFISGHEWIPVTANTPSVKSTDPPPAELFDQGPSDLYSDTAGHLGPYLKPEEIINNLDAVPLAALSSTTETASLQRPAVVERPAVNDYLNPCEPNPCGAGVCSVKDGVGLCHCPPGLHGEECQFEVDVCHSNPCANGATCVEVEDTFKCLCLPSYEGDRCETDSHSCEKGWTKFQGNCYLHFSKRETWLDAEQRCRDLNAHLVSINTPEEQAFVNSNAQDYQWIGLNDKTVENDFRWSDGTQLQFENWRPNQPDNYFNSEEDCVVMIWHENGQWNDVPCNYHLPFTCKSGPVTCDKPPKVENAKMFGNKKERYQVNSIIRYQCSENFTQRHPPVIRCMADGQWEKPKVQCIPKVKFGLHDKSVHHSHKARTALEKQL", "length": 1547 }, "evidence": [ { "id": "MGI:99602", "url": "https://alliancegenome.org/gene/MGI:99602#orthology", "database": "AGR" }, { "id": "HGNC:319", "url": "https://alliancegenome.org/gene/HGNC:319#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-050208-221", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-050208-221#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P07897-1", "protein_name": "Aggrecan core protein", "gene_name": "Acan", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTTLLLVFVTLRVIAAVISEEVPDHDNSLSVSIPQPSPLKALLGTSLTIPCYFIDPMHPVTTAPSTAPLTPRIKWSRVSKEKEVVLLVATEGQVRVNSIYQDKVSLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSEATLEVIVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRTVGARLATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITIQTVTWPDLELPLPRNITEGEARGNVILTAKPIFDMSPTVSEPGEALTLAPEVGTTVFPEAGERTEKTTRPWGFPEEATRGPDSATAFASEDLVVRVTISPGAVEVPGQPRLPGGVVFHYRPGSTRYSLTFEEAQQACIRTGAAIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSSETYDVYCYVDKLEGEVFFATQMEQFTFQEAQAFCAAQNATLASTGQLYAAWSQGLDKCYAGWLADGTLRYPIVNPRPACGGDKPGVRTVYLYPNQTGLPDPLSKHHAFCFRGVSVVPSPGGTPTSPSDIEDWIVTRVEPGVDAVPLEPETTEVPYFTTEPEKQTEWEPAYTPVGTSPLPGIPPTWLPTVPAAEEHTESPSASQEPSASQVPSTSEEPYTPSLAVPSGTELPSSGDTSGAPDLSGDFTGSTDTSGRLDSSGEPSGGSESGLPSGDLDSSGLGPTVSSGLPVESGSASGDGEIPWSSTPTVDRLPSGGESLEGSASASGTGDLSGLPSGGEITETSASGTEEISGLPSGGDDLETSTSGIDGASVLPTGRGGLETSASGVEDLSGLPSGEEGSETSTSGIEDISVLPTGESPETSASGVGDLSGLPSGGESLETSASGVEDVTQLPTERGGLETSASGIEDITVLPTGRENLETSASGVEDVSGLPSGKEGLETSASGIEDISVFPTEAEGLETSASGGYVSGIPSGEDGTETSTSGVEGVSGLPSGGEGLETSASGVEDLGLPTRDSLETSASGVDVTGYPSGREDTETSVPGVGDDLSGLPSGQEGLETSASGAEDLGGLPSGKEDLVGSASGALDFGKLPSGTLGSGQTPEASGLPSGFSGEYSGVDIGSGPSSGLPDFSGLPSGFPTVSLVDSTLVEVITATTASELEGRGTISVSGSGEESGPPLSELDSSADISGLPSGTELSGQTSGSLDVSGETSGFFDVSGQPFGSSGTGEGTSGIPEVSGQAVRSPDTTEISELSGLSSGQPDVSGEGSGILFGSGQSSGITSVSGETSGISDLSGQPSGFPVLSGTTPGTPDLASGAMSGSGDSSGITFVDTSLIEVTPTTFREEEGLGSVELSGLPSGETDLSGTSGMVDVSGQSSGAIDSSGLISPTPEFSGLPSGVAEVSGEVSGVETGSSLSSGAFDGSGLVSGFPTVSLVDRTLVESITLAPTAQEAGEGPSSILEFSGAHSGTPDISGDLSGSLDQSTWQPGWTEASTEPPSSPYFSGDFSSTTDASGESITAPTGSGETSGLPEVTLITSELVEGVTEPTVSQELGHGPSMTYTPRLFEASGEASASGDLGGPVTIFPGSGVEASVPEGSSDPSAYPEAGVGVSAAPEASSQLSEFPDLHGITSASRETDLEMTTPGTEVSSNPWTFQEGTREGSAAPEVSGESSTTSDIDAGTSGVPFATPMTSGDRTEISGEWSDHTSEVNVTVSTTVPESRWAQSTQHPTETLQEIGSPNPSYSGEETQTAETAKSLTDTPTLASPEGSGETESTAADQEQCEEGWTKFQGHCYRHFPDRETWVDAERRCREQQSHLSSIVTPEEQEFVNKNAQDYQWIGLNDRTIEGDFRWSDGHSLQFEKWRPNQPDNFFATGEDCVVMIWHERGEWNDVPCNYQLPFTCKKGTVACGEPPAVEHARTLGQKKDRYEISSLVRYQCTEGFVQRHVPTIRCQPSADWEEPRITCTDPNTYKHRLQKRTMRPTRRSRPSMAH", "length": 2124 }, "evidence": [ { "id": "MGI:99602", "url": "https://alliancegenome.org/gene/MGI:99602#orthology", "database": "AGR" }, { "id": "HGNC:319", "url": "https://alliancegenome.org/gene/HGNC:319#orthology", "database": "AGR" }, { "id": "RGD:68358", "url": "https://alliancegenome.org/gene/RGD:68358#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-100422-16", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-100422-16#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q61282-1", "protein_name": "Aggrecan core protein", "gene_name": "Acan", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTTLLLVFVTLRVIAAVISEEVPDHDNSLSVSIPQPSPLKVLLGSSLTIPCYFIDPMHPVTTAPSTAPLTPRIKWSRVSKEKEVVLLVATEGQVRVNSIYQDKVSLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSEATLEVIVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEDDITIQTVTWPDLELPLPRNVTEGEALGSVILTAKPIFDLSPTISEPGEALTLAPEVGSTAFPEAEERTGEATRPWGFPAEVTRGPDSATAFASEDLVVRVTISPGAAEVPGQPRLPGGVVFHYRPGSTRYSLTFEEAQQACMHTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSSETYDVYCYVDKLEGEVFFATRLEQFTFQEARAFCAAQNATLASTGQLYAAWSQGLDKCYAGWLADGTLRYPIITPRPACGGDKPGVRTVYLYPNQTGLPDPLSKHHAFCFRGVSVAPSPGEEGGSTPTSPSDIEDWIVTQVGPGVDAVPLEPKTTEVPYFTTEPRKQTEWEPAYTPVGTSPQPGIPPTWLPTLPAAEEHTESPSASEEPSASAVPSTSEEPYTSSFAVPSMTELPGSGEASGAPDLSGDFTGSGDASGRLDSSGQPSGGIESGLPSGDLDSSGLSPTVSSGLPVESGSASGDGEVPWSHTPTVGRLPSGGESPEGSASASGTGDLSGLPSGGEITETSTSGAEETSGLPSGGDGLETSTSGVDDVSGIPTGREGLETSASGVEDLSGLPSGEEGSETSTSGIEDISVLPTGGESLETSASGVGDLSGLPSGGESLETSASGAEDVTQLPTERGGLETSASGVEDITVLPTGRESLETSASGVEDVSGLPSGREGLETSASGIEDISVFPTEAEGLDTSASGGYVSGIPSGGDGTETSASGVEDVSGLPSGGEGLETSASGVEDLGPSTRDSLETSASGVDVTGFPSGRGDPETSVSGVGDDFSGLPSGKEGLETSASGAEDLSGLPSGKEDLVGSASGALDFGKLPPGTLGSGQTPEVNGFPSGFSGEYSGADIGSGPSSGLPDFSGLPSGFPTVSLVDSTLVEVITATTSSELEGRGTIGISGSGEVSGLPLGELDSSADISGLPSGTELSGQASGSPDSSGETSGFFDVSGQPFGSSGVSEETSGIPEISGQPSGTPDTTATSGVTELNELSSGQPDVSGDGSGILFGSGQSSGITSVSGETSGISDLSGQPSGFPVFSGTATRTPDLASGTISGSGESSGITFVDTSFVEVTPTTFREEEGLGSVELSGFPSGETELSGTSGTVDVSEQSSGAIDSSGLTSPTPEFSGLPSGVAEVSGEFSGVETGSSLPSGAFDGSGLVSGFPTVSLVDRTLVESITQAPTAQEAGEGPSGILEFSGAHSGTPDISGELSGSLDLSTLQSGQMETSTETPSSPYFSGDFSSTTDVSGESIAATTGSGESSGLPEVTLNTSELVEGVTEPTVSQELGHGPSMTYTPRLFEASGDASASGDLGGAVTNFPGSGIEASVPEASSDLSAYPEAGVGVSAAPEASSKLSEFPDLHGITSAFHETDLEMTTPSTEVNSNPWTFQEGTREGSAAPEVSGESSTTSDIDTGTSGVPSATPMASGDRTEISGEWSDHTSEVNVAISSTITESEWAQPTRYPTETLQEIESPNPSYSGEETQTAETTMSLTDAPTLSSSEGSGETESTVADQEQCEEGWTKFQGHCYRHFHDRETWVDAERRCREQQSHLSSIVTPEEQEFVNKNAQDYQWIGLNDRTIEGDFRWSDGHSLQFEKWRPNQPDNFFATGEDCVVMIWHERGEWNDVPCNYQLPFTCKKGTVACGDPPVVEHARTLGQKKDRYEISSLVRYQCTEGFVQRHVPTIRCQPSGHWEEPRITCTDPNTYKHRLQKRSMRPTRRSRPSMAH", "length": 2132 }, "evidence": [ { "id": "MGI:99602", "url": "https://alliancegenome.org/gene/MGI:99602#orthology", "database": "AGR" }, { "id": "HGNC:319", "url": "https://alliancegenome.org/gene/HGNC:319#orthology", "database": "AGR" }, { "id": "RGD:68358", "url": "https://alliancegenome.org/gene/RGD:68358#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-050208-221", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-050208-221#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-100422-16", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-100422-16#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "P16112", "url": "https://www.uniprot.org/uniprotkb/P16112" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "P16112", "url": "https://www.uniprot.org/uniprotkb/P16112" } ], "pmid": "" }, { "name": "Golgi lumen", "id": "GO:0005796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005796", "evidence": [ { "database": "UniProtKB", "id": "P16112", "url": "https://www.uniprot.org/uniprotkb/P16112" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "P16112", "url": "https://www.uniprot.org/uniprotkb/P16112" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "P16112", "url": "https://www.uniprot.org/uniprotkb/P16112" } ], "pmid": "" }, { "name": "lysosomal lumen", "id": "GO:0043202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043202", "evidence": [ { "database": "UniProtKB", "id": "P16112", "url": "https://www.uniprot.org/uniprotkb/P16112" } ], "pmid": "" }, { "name": "perineuronal net", "id": "GO:0072534", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072534", "evidence": [ { "database": "UniProtKB", "id": "P16112", "url": "https://www.uniprot.org/uniprotkb/P16112" } ], "pmid": "" }, { "name": "gel phase of interstitial matrix", "id": "GO:0140150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140150", "evidence": [ { "database": "UniProtKB", "id": "P16112", "url": "https://www.uniprot.org/uniprotkb/P16112" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "P16112", "url": "https://www.uniprot.org/uniprotkb/P16112" } ], "pmid": "" }, { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "P16112", "url": "https://www.uniprot.org/uniprotkb/P16112" } ], "pmid": "" }, { "name": "central nervous system development", "id": "GO:0007417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007417", "evidence": [ { "database": "UniProtKB", "id": "P16112", "url": "https://www.uniprot.org/uniprotkb/P16112" } ], "pmid": "" }, { "name": "skeletal system development", "id": "GO:0001501", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001501", "evidence": [ { "database": "UniProtKB", "id": "P16112", "url": "https://www.uniprot.org/uniprotkb/P16112" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "P16112", "url": "https://www.uniprot.org/uniprotkb/P16112" } ], "pmid": "" }, { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "P16112", "url": "https://www.uniprot.org/uniprotkb/P16112" } ], "pmid": "" }, { "name": "extracellular matrix structural constituent", "id": "GO:0005201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005201", "evidence": [ { "database": "UniProtKB", "id": "P16112", "url": "https://www.uniprot.org/uniprotkb/P16112" } ], "pmid": "" }, { "name": "hyaluronic acid binding", "id": "GO:0005540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005540", "evidence": [ { "database": "UniProtKB", "id": "P16112", "url": "https://www.uniprot.org/uniprotkb/P16112" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "P16112", "url": "https://www.uniprot.org/uniprotkb/P16112" } ], "pmid": "" } ] } ] }, "pro_annotation": [ { "name": "aggrecan core protein N-glycosylated 1 (human)", "definition": "An aggrecan core protein (human) that has been N-glycosylated at the residue equivalent to Asn-658 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G06247RL. Example: UniProtKB:P16112-1, Asn-658, MOD:00160~GNO:G06247RL. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000055532", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055532" } ] }, { "name": "aggrecan core protein N-glycosylated 2 (human)", "definition": "An aggrecan core protein (human) that has been N-glycosylated at the residue equivalent to Asn-658 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G11115RO. Example: UniProtKB:P16112-1, Asn-658, MOD:00160~GNO:G11115RO. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000055533", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055533" } ] }, { "name": "aggrecan core protein O-glycosylated 1 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-1591 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Ser-1591, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055534", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055534" } ] }, { "name": "aggrecan core protein O-glycosylated 2 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-1599 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Ser-1599, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055535", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055535" } ] }, { "name": "aggrecan core protein O-glycosylated 3 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-1623 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Ser-1623, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055536", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055536" } ] }, { "name": "aggrecan core protein O-glycosylated 4 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-1623 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Ser-1623, MOD:00002~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055537", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055537" } ] }, { "name": "aggrecan core protein O-glycosylated 5 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-1630 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Ser-1630, MOD:00002~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055538", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055538" } ] }, { "name": "aggrecan core protein O-glycosylated 6 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-1693 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Ser-1693, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055539", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055539" } ] }, { "name": "aggrecan core protein O-glycosylated 7 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-1720 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Ser-1720, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055540", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055540" } ] }, { "name": "aggrecan core protein O-glycosylated 8 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-1720 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Ser-1720, MOD:00002~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055541", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055541" } ] }, { "name": "aggrecan core protein O-glycosylated 9 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-1856 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Ser-1856, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055542", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055542" } ] }, { "name": "aggrecan core protein O-glycosylated 10 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-1889 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Ser-1889, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055543", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055543" } ] }, { "name": "aggrecan core protein O-glycosylated 11 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-1895 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P16112-1, Ser-1895, MOD:00002~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055544", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055544" } ] }, { "name": "aggrecan core protein O-glycosylated 12 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-1895 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Ser-1895, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055545", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055545" } ] }, { "name": "aggrecan core protein O-glycosylated 13 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-1895 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Ser-1895, MOD:00002~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055546", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055546" } ] }, { "name": "aggrecan core protein O-glycosylated 14 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-1899 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Ser-1899, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055547", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055547" } ] }, { "name": "aggrecan core protein O-glycosylated 15 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-1915 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Ser-1915, MOD:00002~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055548", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055548" } ] }, { "name": "aggrecan core protein O-glycosylated 16 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-1929 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Ser-1929, MOD:00002~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055549", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055549" } ] }, { "name": "aggrecan core protein O-glycosylated 17 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-1930 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Ser-1930, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055550", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055550" } ] }, { "name": "aggrecan core protein O-glycosylated 18 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-1959 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Ser-1959, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055551", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055551" } ] }, { "name": "aggrecan core protein O-glycosylated 19 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-1969 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Ser-1969, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055552", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055552" } ] }, { "name": "aggrecan core protein O-glycosylated 20 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-2101 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Ser-2101, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055553", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055553" } ] }, { "name": "aggrecan core protein O-glycosylated 21 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-2101 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G57317CE. Example: UniProtKB:P16112-1, Ser-2101, MOD:00002~GNO:G57317CE. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055554", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055554" } ] }, { "name": "aggrecan core protein O-glycosylated 22 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-2124 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Ser-2124, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055555", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055555" } ] }, { "name": "aggrecan core protein O-glycosylated 23 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-2134 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P16112-1, Ser-2134, MOD:00002~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055556", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055556" } ] }, { "name": "aggrecan core protein O-glycosylated 24 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-2134 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Ser-2134, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055557", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055557" } ] }, { "name": "aggrecan core protein O-glycosylated 25 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-2144 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Ser-2144, MOD:00002~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055558", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055558" } ] }, { "name": "aggrecan core protein O-glycosylated 26 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-2214 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Ser-2214, MOD:00002~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055559", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055559" } ] }, { "name": "aggrecan core protein O-glycosylated 27 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-2238 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Ser-2238, MOD:00002~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055560", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055560" } ] }, { "name": "aggrecan core protein O-glycosylated 28 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-2239 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Ser-2239, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055561", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055561" } ] }, { "name": "aggrecan core protein O-glycosylated 29 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-2239 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Ser-2239, MOD:00002~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055562", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055562" } ] }, { "name": "aggrecan core protein O-glycosylated 30 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-2239 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:P16112-1, Ser-2239, MOD:00002~GNO:G58001LT. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055563", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055563" } ] }, { "name": "aggrecan core protein O-glycosylated 31 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-2240 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P16112-1, Ser-2240, MOD:00002~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055564", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055564" } ] }, { "name": "aggrecan core protein O-glycosylated 32 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-2240 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Ser-2240, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055565", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055565" } ] }, { "name": "aggrecan core protein O-glycosylated 33 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-23 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Ser-23, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055566", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055566" } ] }, { "name": "aggrecan core protein O-glycosylated 34 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-30 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Ser-30, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055567", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055567" } ] }, { "name": "aggrecan core protein O-glycosylated 35 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-408 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Ser-408, MOD:00002~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055568", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055568" } ] }, { "name": "aggrecan core protein O-glycosylated 36 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-65 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P16112-1, Ser-65, MOD:00002~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055569", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055569" } ] }, { "name": "aggrecan core protein O-glycosylated 37 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-65 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Ser-65, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055570", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055570" } ] }, { "name": "aggrecan core protein O-glycosylated 38 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-906 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Ser-906, MOD:00002~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055571", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055571" } ] }, { "name": "aggrecan core protein O-glycosylated 39 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Ser-910 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Ser-910, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055572", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055572" } ] }, { "name": "aggrecan core protein O-glycosylated 40 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-1080 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-1080, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055573", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055573" } ] }, { "name": "aggrecan core protein O-glycosylated 41 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-1383 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-1383, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055574", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055574" } ] }, { "name": "aggrecan core protein O-glycosylated 42 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-1461 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-1461, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055575", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055575" } ] }, { "name": "aggrecan core protein O-glycosylated 43 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-1622 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Thr-1622, MOD:00005~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055576", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055576" } ] }, { "name": "aggrecan core protein O-glycosylated 44 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-1683 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-1683, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055577", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055577" } ] }, { "name": "aggrecan core protein O-glycosylated 45 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-1683 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Thr-1683, MOD:00005~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055578", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055578" } ] }, { "name": "aggrecan core protein O-glycosylated 46 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-1842 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-1842, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055579", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055579" } ] }, { "name": "aggrecan core protein O-glycosylated 47 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-1881 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-1881, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055580", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055580" } ] }, { "name": "aggrecan core protein O-glycosylated 48 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-1888 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-1888, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055581", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055581" } ] }, { "name": "aggrecan core protein O-glycosylated 49 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-1888 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Thr-1888, MOD:00005~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055582", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055582" } ] }, { "name": "aggrecan core protein O-glycosylated 50 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-1891 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-1891, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055583", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055583" } ] }, { "name": "aggrecan core protein O-glycosylated 51 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-1927 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Thr-1927, MOD:00005~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055584", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055584" } ] }, { "name": "aggrecan core protein O-glycosylated 52 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-1933 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P16112-1, Thr-1933, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055585", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055585" } ] }, { "name": "aggrecan core protein O-glycosylated 53 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-1933 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-1933, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055586", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055586" } ] }, { "name": "aggrecan core protein O-glycosylated 54 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-1946 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-1946, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055587", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055587" } ] }, { "name": "aggrecan core protein O-glycosylated 55 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-1950 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-1950, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055588", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055588" } ] }, { "name": "aggrecan core protein O-glycosylated 56 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2035 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Thr-2035, MOD:00005~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055589", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055589" } ] }, { "name": "aggrecan core protein O-glycosylated 57 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2035 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G88713AC. Example: UniProtKB:P16112-1, Thr-2035, MOD:00005~GNO:G88713AC. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055590", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055590" } ] }, { "name": "aggrecan core protein O-glycosylated 58 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2046 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-2046, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055591", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055591" } ] }, { "name": "aggrecan core protein O-glycosylated 59 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2046 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:P16112-1, Thr-2046, MOD:00005~GNO:G58001LT. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055592", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055592" } ] }, { "name": "aggrecan core protein O-glycosylated 60 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2049 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P16112-1, Thr-2049, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055593", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055593" } ] }, { "name": "aggrecan core protein O-glycosylated 61 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2049 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-2049, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055594", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055594" } ] }, { "name": "aggrecan core protein O-glycosylated 62 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2049 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Thr-2049, MOD:00005~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055595", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055595" } ] }, { "name": "aggrecan core protein O-glycosylated 63 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2061 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P16112-1, Thr-2061, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055596", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055596" } ] }, { "name": "aggrecan core protein O-glycosylated 64 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2061 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-2061, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055597", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055597" } ] }, { "name": "aggrecan core protein O-glycosylated 65 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2063 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-2063, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055598", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055598" } ] }, { "name": "aggrecan core protein O-glycosylated 66 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2083 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-2083, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055599", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055599" } ] }, { "name": "aggrecan core protein O-glycosylated 67 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2083 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Thr-2083, MOD:00005~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055600", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055600" } ] }, { "name": "aggrecan core protein O-glycosylated 68 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2103 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:P16112-1, Thr-2103, MOD:00005~GNO:G58001LT. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055601", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055601" } ] }, { "name": "aggrecan core protein O-glycosylated 69 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2132 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P16112-1, Thr-2132, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055602", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055602" } ] }, { "name": "aggrecan core protein O-glycosylated 70 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2132 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-2132, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055603", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055603" } ] }, { "name": "aggrecan core protein O-glycosylated 71 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2132 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Thr-2132, MOD:00005~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055604", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055604" } ] }, { "name": "aggrecan core protein O-glycosylated 72 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2132 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G57317CE. Example: UniProtKB:P16112-1, Thr-2132, MOD:00005~GNO:G57317CE. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055605", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055605" } ] }, { "name": "aggrecan core protein O-glycosylated 73 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2132 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:P16112-1, Thr-2132, MOD:00005~GNO:G58001LT. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055606", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055606" } ] }, { "name": "aggrecan core protein O-glycosylated 74 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2133 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P16112-1, Thr-2133, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055607", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055607" } ] }, { "name": "aggrecan core protein O-glycosylated 75 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2133 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-2133, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055608", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055608" } ] }, { "name": "aggrecan core protein O-glycosylated 76 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2133 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Thr-2133, MOD:00005~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055609", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055609" } ] }, { "name": "aggrecan core protein O-glycosylated 77 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2188 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Thr-2188, MOD:00005~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055610", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055610" } ] }, { "name": "aggrecan core protein O-glycosylated 78 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2190 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-2190, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055611", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055611" } ] }, { "name": "aggrecan core protein O-glycosylated 79 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2190 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Thr-2190, MOD:00005~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055612", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055612" } ] }, { "name": "aggrecan core protein O-glycosylated 80 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2196 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P16112-1, Thr-2196, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055613", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055613" } ] }, { "name": "aggrecan core protein O-glycosylated 81 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2196 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-2196, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055614", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055614" } ] }, { "name": "aggrecan core protein O-glycosylated 82 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-22 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-22, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055615", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055615" } ] }, { "name": "aggrecan core protein O-glycosylated 83 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2215 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-2215, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055616", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055616" } ] }, { "name": "aggrecan core protein O-glycosylated 84 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2223 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Thr-2223, MOD:00005~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055617", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055617" } ] }, { "name": "aggrecan core protein O-glycosylated 85 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2226 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-2226, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055618", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055618" } ] }, { "name": "aggrecan core protein O-glycosylated 86 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2255 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-2255, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055619", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055619" } ] }, { "name": "aggrecan core protein O-glycosylated 87 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2258 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P16112-1, Thr-2258, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055620", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055620" } ] }, { "name": "aggrecan core protein O-glycosylated 88 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2258 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-2258, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055621", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055621" } ] }, { "name": "aggrecan core protein O-glycosylated 89 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-371 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Thr-371, MOD:00005~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055622", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055622" } ] }, { "name": "aggrecan core protein O-glycosylated 90 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-374 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P16112-1, Thr-374, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055623", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055623" } ] }, { "name": "aggrecan core protein O-glycosylated 91 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-374 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-374, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055624", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055624" } ] }, { "name": "aggrecan core protein O-glycosylated 92 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-374 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Thr-374, MOD:00005~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055625", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055625" } ] }, { "name": "aggrecan core protein O-glycosylated 93 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-374 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:P16112-1, Thr-374, MOD:00005~GNO:G58001LT. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055626", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055626" } ] }, { "name": "aggrecan core protein O-glycosylated 94 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-376 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P16112-1, Thr-376, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055627", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055627" } ] }, { "name": "aggrecan core protein O-glycosylated 95 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-376 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-376, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055628", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055628" } ] }, { "name": "aggrecan core protein O-glycosylated 96 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-400 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P16112-1, Thr-400, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055629", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055629" } ] }, { "name": "aggrecan core protein O-glycosylated 97 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-436 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-436, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055630", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055630" } ] }, { "name": "aggrecan core protein O-glycosylated 98 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-440 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-440, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055631", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055631" } ] }, { "name": "aggrecan core protein O-glycosylated 99 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-447 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-447, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055632", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055632" } ] }, { "name": "aggrecan core protein O-glycosylated 100 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-466 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-466, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055633", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055633" } ] }, { "name": "aggrecan core protein O-glycosylated 101 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-61 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Thr-61, MOD:00005~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055634", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055634" } ] }, { "name": "aggrecan core protein O-glycosylated 102 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-61 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:P16112-1, Thr-61, MOD:00005~GNO:G58001LT. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055635", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055635" } ] }, { "name": "aggrecan core protein O-glycosylated 103 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-703 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-703, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055636", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055636" } ] }, { "name": "aggrecan core protein O-glycosylated 104 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-905 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G73004SD. Example: UniProtKB:P16112-1, Thr-905, MOD:00005~GNO:G73004SD. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055637", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055637" } ] }, { "name": "aggrecan core protein O-glycosylated 105 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-907 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P16112-1, Thr-907, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055638", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055638" } ] }, { "name": "aggrecan core protein O-glycosylated 106 (human)", "definition": "An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-907 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P16112-1, Thr-907, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000055639", "database": "PRO", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:000055639" } ] } ], "site_annotation": [ { "start_pos": 126, "end_pos": 128, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2013, "end_pos": 2015, "annotation": "n_glycosylation_sequon" }, { "start_pos": 239, "end_pos": 241, "annotation": "n_glycosylation_sequon" }, { "start_pos": 333, "end_pos": 335, "annotation": "n_glycosylation_sequon" }, { "start_pos": 387, "end_pos": 389, "annotation": "n_glycosylation_sequon" }, { "start_pos": 434, "end_pos": 436, "annotation": "n_glycosylation_sequon" }, { "start_pos": 602, "end_pos": 604, "annotation": "n_glycosylation_sequon" }, { "start_pos": 658, "end_pos": 660, "annotation": "n_glycosylation_sequon" }, { "start_pos": 738, "end_pos": 740, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.", "evidence": [ { "database": "UniProtKB", "id": "P16112", "url": "https://www.uniprot.org/uniprotkb/P16112" }, { "database": "PubMed", "id": "7574678", "url": "https://glygen.org/publication/PubMed/7574678" }, { "database": "PubMed", "id": "16335952", "url": "https://glygen.org/publication/PubMed/16335952" }, { "database": "PubMed", "id": "32337544", "url": "https://glygen.org/publication/PubMed/32337544" }, { "database": "PubMed", "id": "36213313", "url": "https://glygen.org/publication/PubMed/36213313" }, { "database": "PubMed", "id": "1569188", "url": "https://glygen.org/publication/PubMed/1569188" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-P16112-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 2530, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-P16112-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/P16112" }, { "pdb_id": "9dff", "pdb_chain": "a/b", "start_pos": 21, "end_pos": 351, "overlap": "1.0", "method": "X-Ray_Crystallography", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/9dff.pdb", "url_external": "https://www.rcsb.org/structure/9dff" } ], "lectin_list": [ { "lectin_class": "C-type lectin", "evidence": [ { "id": "41178200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/41178200" }, { "id": "10.1002/anie.202508864", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1002/anie.202508864" }, { "id": "7827755", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/7827755" }, { "id": "77", "database": "HumanLectome", "url": "https://unilectin.unige.ch/humanLectome/HL_entryPage?idHL=77" }, { "id": "20137779", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/20137779" }, { "id": "17588949", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/17588949" }, { "id": "7574678", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/7574678" }, { "id": "19110214", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/19110214" }, { "id": "8611178", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8611178" }, { "id": "1326552", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1326552" }, { "id": "7524681", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/7524681" }, { "id": "33990642", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33990642" }, { "id": "33471655", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33471655" }, { "id": "16335952", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16335952" }, { "id": "1985970", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1985970" }, { "id": "7240256", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/7240256" }, { "id": "16080123", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16080123" }, { "id": "8216415", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8216415" }, { "id": "2789216", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/2789216" }, { "id": "33606014", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33606014" }, { "id": "34625928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34625928" }, { "id": "16572171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16572171" }, { "id": "34051020", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34051020" }, { "id": "15489334", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/15489334" }, { "id": "1569188", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1569188" } ] } ], "domain_list": [ { "evidence": [ { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112" }, { "id": "PRU00040", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00040" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C-type lectin", "eco_id": "ECO_0000255", "start_pos": 2327, "end_pos": 2441, "start_aa": "Tyr", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112" }, { "id": "PRU00076", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00076" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000255", "start_pos": 2279, "end_pos": 2314, "start_aa": "Pro", "end_aa": "Asn", "glycosite_overlap": [] }, { "evidence": [ { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112" }, { "id": "PRU00323", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00323" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Link 1", "eco_id": "ECO_0000255", "start_pos": 153, "end_pos": 248, "start_aa": "Ile", "end_aa": "Ala", "glycosite_overlap": [ { "position": 239, "amino_acid": "Asn" } ] }, { "evidence": [ { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112" }, { "id": "PRU00323", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00323" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Link 2", "eco_id": "ECO_0000255", "start_pos": 254, "end_pos": 350, "start_aa": "Glu", "end_aa": "Thr", "glycosite_overlap": [ { "position": 333, "amino_acid": "Asn" } ] }, { "evidence": [ { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112" }, { "id": "PRU00323", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00323" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Link 3", "eco_id": "ECO_0000255", "start_pos": 478, "end_pos": 573, "start_aa": "Val", "end_aa": "Val", "glycosite_overlap": [] }, { "evidence": [ { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112" }, { "id": "PRU00323", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00323" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Link 4", "eco_id": "ECO_0000255", "start_pos": 579, "end_pos": 675, "start_aa": "Glu", "end_aa": "Arg", "glycosite_overlap": [ { "position": 658, "amino_acid": "Asn" }, { "position": 602, "amino_acid": "Asn" } ] }, { "evidence": [ { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112" }, { "id": "PRU00302", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00302" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sushi", "eco_id": "ECO_0000255", "start_pos": 2445, "end_pos": 2505, "start_aa": "Val", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [ { "evidence": [ { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112#function" }, { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112" } ], "binding_site_uniprot": 2381, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 2381, "end_pos": 2381, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112#function" }, { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112" } ], "binding_site_uniprot": 2385, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 2385, "end_pos": 2385, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112#function" }, { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112" } ], "binding_site_uniprot": 2405, "amino_acid": "Gln", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 2405, "end_pos": 2405, "start_aa": "Gln", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112#function" }, { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112" } ], "binding_site_uniprot": 2407, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 2407, "end_pos": 2407, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112#function" }, { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112" } ], "binding_site_uniprot": 2408, "amino_acid": "Asn", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 2408, "end_pos": 2408, "start_aa": "Asn", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112#function" }, { "id": "P16112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16112" } ], 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